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1. Biomedical articles (top 50; 2009 to 2014)
1. ||||||.... 57%  Moloney TP, Trinh T, Farrah JJ: A case of conjunctival mucoepidermoid carcinoma in Australia. Clin Ophthalmol; 2014;8:11-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of conjunctival mucoepidermoid carcinoma in Australia.
  • Conjunctival mucoepidermoid carcinoma is a very rare but highly aggressive conjunctival neoplasm with 42 previously reported cases.
  • We report the case of a 56-year-old male with a left ocular surface squamous neoplasm, which was subsequently treated with excision and autoconjunctival graft.
  • Histopathology of the operative specimen reported a low-grade conjunctival mucoepidermoid carcinoma, and the patient was then treated with an adjunctive course of mitomycin C.
  • Due to its rare incidence, difficult clinical diagnosis, and accompanying poor prognosis, conjunctival mucoepidermoid carcinoma should always be considered in the differential diagnosis of conjunctival neoplasms, and full histopathologic examination, including mucin-staining techniques, of all suspicious conjunctival biopsies should occur.

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  • (PMID = 24363552.001).
  • [ISSN] 1177-5467
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3862775
  • [Keywords] NOTNLM ; conjunctiva / mitomycin C / neoplasm / pterygium
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2. |||||..... 48%  Saornil MA, Becerra E, Méndez MC, Blanco G: [Conjunctival tumors]. Arch Soc Esp Oftalmol; 2009 Jan;84(1):7-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Conjunctival tumors].
  • [Transliterated title] Tumores de la conjuntiva.
  • Conjunctival tumors are one of the most frequent of the eye and adnexa.
  • In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / surgery. Conjunctival Diseases / pathology. Conjunctival Diseases / surgery. Eye Enucleation. Eye Evisceration. Hematologic Neoplasms / pathology. Hematologic Neoplasms / surgery. Humans. Melanoma / pathology. Melanoma / surgery. Neoplasm Invasiveness. Nevus / pathology. Nevus / surgery. Papilloma / pathology. Papilloma / surgery. Precancerous Conditions / pathology. Precancerous Conditions / surgery. Sarcoma / pathology. Sarcoma / surgery

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  • (PMID = 19173134.001).
  • [ISSN] 1989-7286
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 47
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3. ||||...... 44%  Cooper IF, Siadaty MS: 'Steroids' associated with 'Conjunctival Neoplasm': Top Publications. BioMedLib Review; Steroid;ConjunctivalNeoplasm:705526978. ISSN: 2331-5717. 2014/4/23
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  • [Title] 'Steroids' associated with 'Conjunctival Neoplasm': Top Publications.
  • Background: There are articles published each month which present 'steroid' for 'conjunctival neoplasm'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Chance B: A case exhibiting a symblepharon, corneal opacities and a probably fibro-fatty tumor of the conjunctiva, all of pre-natal origin, in a woman with hereditary cataracts at an early age.
  • Feng G et al: [777 cases of the primary conjunctival neoplasms].
  • Ozcan AA et al: Topical mitomycin C for the treatment of conjunctival tumor.
  • Furdová A et al: [The TNM classification system in malignant conjunctival neoplasms].
  • Yeatts RP et al: Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.
  • Margo CE et al: Borderline melanocytic tumor of the conjunctiva: diagnostic and therapeutic considerations.
  • Favini F et al: Inflammatory myofibroblastic tumor of the conjunctiva: response to chemotherapy with low-dose methotrexate and vinorelbine.
  • Margo CE et al: Intraepithelial neoplasia of the conjunctiva with mucoepidermoid differentiation.
  • Pe'er J et al: Solitary fibrous tumor of the conjunctiva.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705526978.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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4. ||||...... 35%  Levy-Gabriel C: [Suspicious conjunctival lesions]. J Fr Ophtalmol; 2010 Feb;33(2):125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Suspicious conjunctival lesions].
  • [Transliterated title] Taches suspectes de la conjonctive.
  • The main conjunctival tumors are represented by (i) conjunctival melanoma, ocular surface squamous neoplasia, and conjunctival lymphoma, which are malignant tumors, and (ii) conjunctival nevus, papilloma, and choristoma, which are benign.
  • In usual practice, ophthalmologists need to know how to differentiate conjunctival melanomas and carcinomas from the other conjunctival tumors by clinical examination.
  • Indeed, the therapeutic approach to these two malignant diseases presents a number of particularities such as the need for surgery under general anesthesia, if possible, to minimize the risk of local dissemination and further local recurrence, and detailed information on the tumor location and measurements before surgery (Figures, diagram, sizes) to precisely define the irradiation field during complementary radiotherapy.
  • The clinical signs and main therapeutic principles of conjunctival tumors are reviewed in this article.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Ophthalmology / methods
  • [MeSH-minor] Choristoma / diagnosis. Combined Modality Therapy. Diagnosis, Differential. Humans. Lymphoma / diagnosis. Melanoma / diagnosis. Neoplasm Staging. Neoplasms, Squamous Cell / diagnosis. Nevus / diagnosis. Papilloma / diagnosis. Pigmentation. Precancerous Conditions / diagnosis

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20096479.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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5. |||....... 30%  Alves LF, Fernandes BF, Burnier JV, Zoroquiain P, Eskenazi DT, Burnier Jr MN: Incidence of epithelial lesions of the conjunctiva in a review of 12,102 specimens in Canada (Quebec). Arq Bras Oftalmol; 2011 Jan-Feb;74(1):21-3
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  • [Title] Incidence of epithelial lesions of the conjunctiva in a review of 12,102 specimens in Canada (Quebec).
  • PURPOSE: The purpose of this study was to assess the relative frequency of epithelial lesions of the conjunctiva in Canada.
  • The relative frequency of epithelial lesions of the conjunctiva from a single center in Canada, representing the province of Quebec was reviewed.
  • RESULTS: Of the 12,102 specimens reviewed, 273 were conjunctival lesions (2.25%), including 86 epithelial tumors (0.71%) of the conjunctiva that comprised the studied sample.
  • Within the ocular surface squamous neoplasia (OSSN) spectrum, there were 10 (11.6%) actinic keratosis (63.8 ± 17.6 years), 27 (31.3%) cases of conjunctival intraepithelial neoplasia (CIN) with variable degrees of atypia (mild to moderate) (63.9 ± 15.3 years), 15 (17.4%) carcinomas in situ (66.7 ± 18.0 years), and 17 (19.7%) squamous cell carcinomas (SCC) (56.2 ± 19.4 years).
  • Two other rare cases of malignant tumors included one basal cell carcinoma and one mucoepidermoid carcinoma.
  • When we compare our sample to others coming from countries with high levels of sunlight exposure, we found a lower incidence of ocular surface squamous neoplasia, including squamous cell carcinomas in Canada.
  • [MeSH-major] Conjunctival Neoplasms / epidemiology

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  • (PMID = 21670902.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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6. |||....... 28%  Kenawy N, Lake SL, Coupland SE, Damato BE: Conjunctival melanoma and melanocytic intra-epithelial neoplasia. Eye (Lond); 2013 Feb;27(2):142-52
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  • [Title] Conjunctival melanoma and melanocytic intra-epithelial neoplasia.
  • The rarity of conjunctival melanoma has impeded progress in the management of patients with this cancer; however, much progress has occurred in recent years.
  • Primary acquired melanosis is now differentiated histologically into hypermelanosis and conjunctival melanocytic intra-epithelial neoplasia, for which an objective reproducible scoring system has been developed.
  • Mapping and clinical staging of conjunctival disease has improved.
  • Adjunctive radiotherapy and topical chemotherapy have made tumour control more successful, with reduced morbidity.
  • Genetic analyses have identified BRAF and other mutations, which may predict responsiveness to new chemotherapeutic agents, for example Vemurafenib, should metastatic disease develop.
  • Multicentre studies are under way to enhance survival prediction by integrating clinical stage of disease with histological grade of malignancy and genetic abnormalities.
  • [MeSH-major] Conjunctival Neoplasms / classification. Melanoma / classification
  • [MeSH-minor] Diagnosis, Differential. Humans. Neoplasm Staging. Proto-Oncogene Proteins B-raf / genetics

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  • (PMID = 23222568.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
  • [Other-IDs] NLM/ PMC3574254
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7. ||||||.... 56%  Zemba M, Stamate AC, Avram CI, Sîrbu LN, Camburu RL, Ochinciuc U, Burcea M: [Alternative therapeutic excision carcinoma interepitelial conjunctivitis with corneal extension]. Oftalmologia; 2013;57(4):22-6
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  • [Transliterated title] Alternative terapeutice la excizia unui carcinom intraepitelial conjunctival cu extensie corneeană.
  • Surgical treatment for conjunctival neoplasms, with wide local excision, with or without supplemental cryotherapy to the surgical margins represents the treatment of choice for this pathology.
  • In some cases, these neoplasms can be diffuse or multifocal, with borders that are difficult to detect clinically, such that topical therapies offer a more efficient method for treating the entire ocular surface, delivering high drug concentrations at this level, with negligible systemic side effects.
  • Beginning from the clinical case of a patient diagnosed with conjunctival intraepithelial neoplasia, we try to present other therapeutical alternatives, although in this case the therapeutical approach was the classic one.

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  • (PMID = 24844033.001).
  • [ISSN] 1220-0875
  • [Journal-full-title] Oftalmologia (Bucharest, Romania : 1990)
  • [ISO-abbreviation] Oftalmologia
  • [Language] rum
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Romania
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8. |||||..... 52%  Maschi C, Caujolle JP, Liolios I, Costet C: [Benign conjunctival tumors]. J Fr Ophtalmol; 2013 Nov;36(9):796-802
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Benign conjunctival tumors].
  • [Transliterated title] Tumeurs conjonctivales bénignes.
  • Benign conjunctival tumors include congenital, melanocytic, epithelial and stromal lesions.
  • Onco-ophthalmologists must have a perfect knowledge of benign conjunctival tumors, since during adulthood, nevi can be confused with melanomas, and epithelial or stromal lesions with carcinomas.
  • [MeSH-major] Conjunctival Neoplasms
  • [MeSH-minor] Adenoma / diagnosis. Adenoma / pathology. Adolescent. Adult. Humans. Keratoacanthoma / diagnosis. Keratoacanthoma / pathology. Melanoma / diagnosis. Melanoma / pathology. Neoplasms, Nerve Tissue / diagnosis. Neoplasms, Nerve Tissue / pathology. Neoplasms, Vascular Tissue / diagnosis. Neoplasms, Vascular Tissue / pathology. Nevus, Pigmented / diagnosis. Nevus, Pigmented / pathology

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  • [Copyright] Copyright © 2013 Elsevier Masson SAS. All rights reserved.
  • (PMID = 24099696.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Keywords] NOTNLM ; Congenital tumors / Conjonctive / Conjunctiva / Epithelial tumors / Melanocytic tumors / Stromal tumors / Tumeurs congénitales / Tumeurs mélaniques / Tumeurs stromales / Tumeurs épithéliales
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9. ||||...... 41%  Wiggans KT, Skorupski KA, Reilly CM, Frazier SA, Dubielzig RR, Maggs DJ: Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985-2013). J Am Vet Med Assoc; 2014 Feb 15;244(4):460-70
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  • [Title] Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985-2013).
  • RESULTS: Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively.
  • Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis.
  • Tumors included B-cell (2 intraocular and 1 conjunctival), non-B-cell, non-T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined.
  • Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival).
  • Lymph node metastasis was detected in 2 patients with conjunctival lymphoma.
  • Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively.
  • Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

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  • (PMID = 24479461.001).
  • [ISSN] 1943-569X
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. |||....... 32%  Harooni H, Schoenfield LR, Singh AD: Current appraisal of conjunctival melanocytic tumors: classification and treatment. Future Oncol; 2011 Mar;7(3):435-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current appraisal of conjunctival melanocytic tumors: classification and treatment.
  • Conjunctival melanocytic tumors represent a spectrum of pigmented tumors that include benign, premalignant and malignant tumors.
  • Conjunctival nevi are the most common pigmented tumors and are typically found in the interpalpebral bulbar conjunctiva.
  • Conjunctival melanoma represents only 5% of all melanomas arising in the ocular region and is associated with a high mortality rate.
  • The management of primary acquired melanosis, nevi and conjunctival melanomas involves various modalities used either alone or concomitantly depending on the size and extent of the lesion.
  • [MeSH-major] Conjunctival Neoplasms / classification. Conjunctival Neoplasms / therapy

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  • (PMID = 21417906.001).
  • [ISSN] 1744-8301
  • [Journal-full-title] Future oncology (London, England)
  • [ISO-abbreviation] Future Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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11. |||....... 31%  Tost F, Evert M: [Conjunctival tumours in elderly patients]. Klin Monbl Augenheilkd; 2010 Jan;227(1):33-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Conjunctival tumours in elderly patients].
  • [Transliterated title] Tumoren der Bindehaut im Alter.
  • The conjunctiva as a mucous membrane provides a protective barrier to the eye.
  • For this reason conjunctival ageing is affected by equivalent processes as skin ageing.
  • The resulting dysfunction in conjunctival homoeostasis and protective function represent common factors which contribute to increased incidences of tumours and malignant transformations in elderly patients.
  • At the time of tumour manifestation the patient's age is an important parameter for differential diagnosis and regimen strategy.
  • [MeSH-major] Conjunctival Neoplasms / surgery. Ophthalmologic Surgical Procedures / methods

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart New York.
  • (PMID = 20091448.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 0 / Ophthalmic Solutions; 50SG953SK6 / Mitomycin
  • [Number-of-references] 52
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12. |||....... 29%  Liu WW, Lin JY, Yu XH: [Clinical and histopathological features of conjunctival myxoma and angiomyxoma]. Zhonghua Yan Ke Za Zhi; 2012 Nov;48(11):981-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical and histopathological features of conjunctival myxoma and angiomyxoma].
  • OBJECTIVE: To explore the clinical and pathological features of conjunctival myxoma and angiomyxoma.
  • The clinical and pathological features of 3 cases of conjunctival myxoma and 2 cases of conjunctival angiomyxoma were analyzed.
  • The tumors presented as yellow-pink, translucent, cystic and(or) with solid masses.
  • Regarding the tumor location, 2 cases involved the temporal side, 1 case involved the nasal side, 1 case involved the nasal limbus and invaded the cornea, and 1 case involved the nasal, temporal and inferior parts.
  • Histopathological examination revealed that the conjunctival myxomas were composed of abundant mucoid material and relatively small numbers of small, ovoid, spindle and stellate shaped cells with sparse vessels.
  • The histologic features of the conjunctival angiomyxoma were similar to those of myxomas with the exception of the former being characterized by a prominent vascular structure.
  • The immunohistochemical staining showed that tumor cells were positive for Vimentin, but negative for S-100 protein; some tumor cells were positive for CD34 and SMA.
  • CONCLUSIONS: Most of the conjunctival myxoma and angiomyxoma appear as a local yellow-pink, translucent, cystic and(or) with solid mass, and some of which had multiple tumors.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Myxoma / pathology

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  • (PMID = 23302270.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. |||....... 29%  Kimura K, Usui Y, Goto H: [Clinical findings and prognosis of 11 cases of conjunctival malignant melanoma]. Nihon Ganka Gakkai Zasshi; 2012 May;116(5):503-9
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  • [Title] [Clinical findings and prognosis of 11 cases of conjunctival malignant melanoma].
  • PURPOSE: To describe the clinical findings and prognosis of conjunctival malignant melanomas.
  • SUBJECTS: We investigated the clinical findings and prognosis of 11 cases of conjunctival malignant melanomas diagnosed and treated at Tokyo Medical University Hospital.
  • Cases arose from primary acquired melanosis (PAM) in 45% of the patients, from conjunctival nevus in 9%, from both conjunctival nevus and PAM in 27% and de novo in 18%.
  • Total surgical excision of the tumor was performed for recurrent lesions.
  • CONCLUSION: A combination of surgical excision with adjuvant therapy has been used for the treatment of conjunctival melanoma.
  • [MeSH-major] Conjunctival Neoplasms. Melanoma
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Prognosis. Treatment Outcome

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  • (PMID = 22690541.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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14. |||....... 28%  Lee A, Li EY, Yuen HK: Inferonasal prolapsed orbital fat: report of a case and review of literature. Ophthal Plast Reconstr Surg; 2013 Jul-Aug;29(4):e110-1
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  • It can be confused with other conjunctival tumors.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctival Neoplasms / pathology

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  • (PMID = 23392315.001).
  • [ISSN] 1537-2677
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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15. |||....... 28%  Yumori JW, Ilsen P, Bright DC: Conjunctival plasmacytoma. Optometry; 2010 May;81(5):234-9
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  • [Title] Conjunctival plasmacytoma.
  • BACKGROUND: Plasmacytomas are plasma cell tumors that may be a primary or secondary tumor focus, the latter of which are associated with multiple myeloma.
  • We present a rare case of a solitary extramedullary plasmacytoma involving the conjunctiva.
  • A vascularized conjunctival lesion was noted in his right eye.
  • The patient underwent excisional biopsy, which found a conjunctival plasmacytoma.
  • CONCLUSION: Although plasmacytomas of the eye and orbit are rare, it is important to be familiar with these tumors that may be associated with multiple myeloma.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Plasmacytoma / diagnosis
  • [MeSH-minor] Adult. Biopsy. Conjunctiva / pathology. Humans. Male

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  • [Copyright] Copyright 2010 American Optometric Association. All rights reserved.
  • (PMID = 20435269.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. |||....... 28%  Hwang SS, Kim JE, Chun BK, Jung S, Park EK, Lee HJ, Jung M, Lee SJ, Noh GM, Masanganise R, Oak C, Ahn YC: New model of subconjunctival tumor development in rabbits. J Biomed Opt; 2013 Jul;18(7):070501
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  • [Title] New model of subconjunctival tumor development in rabbits.
  • Conjunctival squamous cell carcinoma (SCC) is an uncommon disease.
  • However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model.
  • Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans.
  • Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks.
  • This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Disease Models, Animal
  • [MeSH-minor] Animals. Cell Line, Tumor. Conjunctiva / pathology. Male. Neoplasm Transplantation. Rabbits. Tomography, Optical Coherence

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  • (PMID = 23817759.001).
  • [ISSN] 1560-2281
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. |||....... 28%  Kaliki S, Arepalli S, Shields CL, Klein K, Sun H, Hysenj E, Lally SE, Shields JA: Conjunctival papilloma: features and outcomes based on age at initial examination. JAMA Ophthalmol; 2013 May;131(5):585-93
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  • [Title] Conjunctival papilloma: features and outcomes based on age at initial examination.
  • IMPORTANCE: Conjunctival papilloma is a benign epithelial tumor occurring in both children and adults with varying clinical features and outcomes.
  • In this article, we describe our experience regarding the difference in the clinical features and outcomes of conjunctival papilloma based on age at initial examination.
  • OBJECTIVE: To evaluate the clinical features, treatment, and outcomes in patients with conjunctival papilloma based on age at initial examination.
  • PARTICIPANTS: Ten children and adolescents (aged ≤20 years) and 63 adults (aged >20 years) with conjunctival papilloma.
  • MAIN OUTCOME MEASURE: Tumor response.
  • RESULTS: A comparison of conjunctival papillomas between age groups revealed significant differences in the mean number of tumors per eye (children and adolescents vs adults, 2 vs 1; P = .05), tumor basal dimension (8 vs 6 mm; P = .05), and associated feeder vessels (20% vs 47%; P = .05).
  • Significant differences in age groups in treatment outcome during the follow-up period (mean, 24 vs 38 months) included complete regression with single treatment (38% vs 95%; P < .01) and tumor recurrence (15% vs 1%; P = .05).
  • CONCLUSIONS AND RELEVANCE: Conjunctival papillomas are larger and more likely to be multiple in children and adolescents than in adults.
  • Excisional biopsy and cryotherapy with or without adjuvant oral cimetidine and/or topical interferon alfa-2b provide satisfactory tumor control.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Papilloma / pathology

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  • (PMID = 23538642.001).
  • [ISSN] 2168-6173
  • [Journal-full-title] JAMA ophthalmology
  • [ISO-abbreviation] JAMA Ophthalmol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Immunologic Factors; 0 / Interferon-alpha; 0 / Recombinant Proteins; 80061L1WGD / Cimetidine; 99210-65-8 / interferon alfa-2b
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18. |||....... 28%  Kheirkhah A, Mahbod M, Farzbod F, Zavareh MK, Behrouz MJ, Hashemi H: Repeated applications of impression cytology to increase sensitivity for diagnosis of conjunctival intraepithelial neoplasia. Br J Ophthalmol; 2012 Feb;96(2):229-33
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  • [Title] Repeated applications of impression cytology to increase sensitivity for diagnosis of conjunctival intraepithelial neoplasia.
  • PURPOSE: To increase sensitivity of impression cytology (IC) for the diagnosis of conjunctival intraepithelial neoplasia (CIN) by three repeated applications of IC.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Conjunctival Neoplasms / diagnosis. Diagnostic Techniques, Ophthalmological

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  • (PMID = 21498806.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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19. |||....... 27%  Aronow ME, Singh AD: Radiation therapy: conjunctival and eyelid tumors. Dev Ophthalmol; 2013;52:85-93
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  • [Title] Radiation therapy: conjunctival and eyelid tumors.
  • While the primary treatment of eyelid and conjunctival tumors is frequently surgical, several forms of ophthalmic radiation therapy have also been used to treat these malignancies.
  • The goal of radiation therapy is to eradicate tumor burden in a manner that maintains visual function and preserves surrounding sensitive ocular tissues.
  • Ophthalmic radiation may be used as a curative therapy, as adjuvant treatment following surgical excision, or as palliative therapy for advanced cases of eyelid and conjunctival tumors.
  • The following review discusses the indications and outcomes of various modalities of radiation (external beam radiotherapy and brachytherapy) used to treat eyelid tumors (squamous cell carcinoma, basal cell carcinoma, sebaceous gland carcinoma, and melanoma) and conjunctival tumors (squamous cell carcinoma and melanoma).
  • [MeSH-major] Conjunctival Neoplasms / radiotherapy. Eyelid Neoplasms / radiotherapy

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  • [Copyright] Copyright © 2013 S. Karger AG, Basel.
  • (PMID = 23989129.001).
  • [ISSN] 1662-2790
  • [Journal-full-title] Developments in ophthalmology
  • [ISO-abbreviation] Dev Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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20. |||....... 27%  Shildkrot Y, Wilson MW: Conjunctival melanoma: pitfalls and dilemmas in management. Curr Opin Ophthalmol; 2010 Sep;21(5):380-6
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  • [Title] Conjunctival melanoma: pitfalls and dilemmas in management.
  • PURPOSE OF REVIEW: The current dilemmas in the diagnosis and management of conjunctival melanoma are reviewed in this paper.
  • Available evidence for the role of sentinel lymph node biopsy as it applies to conjunctival melanoma is examined.
  • RECENT FINDINGS: The incidence of conjunctival melanoma appears to be on the rise.
  • Analyses of 770 patients with conjunctival melanoma reveals a nearly 50% rate of local recurrence, and up to a 38% 10-year mortality.
  • SUMMARY: The management of conjunctival surface melanomas is complicated by local recurrence and metastatic disease, particularly for lesions greater than 2 mm in thickness and arising from nonbulbar conjunctiva.
  • Conjunctival anatomy and high recurrence rate with resultant metastatic spread undermines the utility of sentinel lymph node biopsy in this condition.
  • Further research and innovation for detection of systemic micrometastases and treatment of metastatic disease are needed.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Melanoma / diagnosis. Melanoma / therapy
  • [MeSH-minor] Antibiotics, Antineoplastic / administration & dosage. Cryotherapy. Humans. Lymphatic Metastasis. Mitomycin / administration & dosage. Neoplasm Recurrence, Local. Sentinel Lymph Node Biopsy

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  • (PMID = 20531189.001).
  • [ISSN] 1531-7021
  • [Journal-full-title] Current opinion in ophthalmology
  • [ISO-abbreviation] Curr Opin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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21. |||....... 26%  Mudhar HS, Rennie IG: Local conjunctival metastases from primary conjunctival melanoma: clinico-pathological correlation and implications. Br J Ophthalmol; 2013 Jan;97(1):33-9
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  • [Title] Local conjunctival metastases from primary conjunctival melanoma: clinico-pathological correlation and implications.
  • BACKGROUND/AIMS: A retrospective service evaluation identified seven patients who developed local conjunctival metastases (LCMs) of the conjunctiva after a primary diagnosis of conjunctival invasive melanoma.
  • METHODS: Seven patients with primary conjunctival melanoma seen by the ocular oncology service were identified as having also developed LCMs.
  • The clinical history, histopathology, tumour biology, prognostic and staging implications of LCMs were evaluated.
  • RESULTS: A total of 15 primary conjunctival melanomas and 19 LCMs were identified.
  • The LCM developed 8-102 months after the first primary melanoma and, in three patients, non-conjunctival metastases developed 8-37 months after the first LCM.
  • CONCLUSIONS: LCMs are local metastases of primary conjunctival melanoma that probably develop by dissemination through the local vessels and then becoming extavascular.
  • Their accurate histopathological recognition is important, as it indicates a higher disease stage-indicating 'N' status within the TNM classification and may be a proxy indicator of the presence of non-conjunctival metastases, thus necessitating high-resolution radiological imaging modalities or sentinel node biopsy.
  • LCMs may represent an under-recognised lesion and may have been mistaken for primary 'nodular' conjunctival melanomas in the past.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanoma / secondary. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Retrospective Studies. Time Factors

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  • (PMID = 23143907.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. |||....... 26%  Herwig MC, Fischer HP, Holz FG, Loeffler KU: [Conjunctival myxoma: two cases. Histopathological examination and clinical course]. Ophthalmologe; 2010 Sep;107(9):843-7
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  • [Title] [Conjunctival myxoma: two cases. Histopathological examination and clinical course].
  • Conjunctival myxoma is a rare and benign tumour without tendency for recurrence.
  • Removal of each tumour was followed by histopathological examination including immunohistochemistry as well as electron microscopy.
  • Besides the expected findings characteristic of conjunctival myxoma some features reflecting the possible aetiology of this entity are shown.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / surgery. Myxoma / pathology. Myxoma / surgery

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  • (PMID = 20376460.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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23. |||....... 26%  Litak J, Dimitropoulos VA, Dy LC, Brown CW, Grostern RJ: Conjunctival papilloma. Cutis; 2012 Jan;89(1):38-40
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  • [Title] Conjunctival papilloma.
  • Conjunctival papillomas are some of the most common tumors of the conjunctiva and are well-described in ophthalmology textbooks.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology. Papilloma / pathology

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  • (PMID = 22439310.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. |||....... 26%  Gonzalez-Alonso-Alegre EM, Rodriguez-Alvaro A, Martinez-Nevado E, Martinez-de-Merlo EM, Sanchez-Maldonado B: Conjunctival squamous cell carcinoma in a reindeer (Rangifer tarandus tarandus). Vet Ophthalmol; 2013 Jul;16 Suppl 1:113-6
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  • [Title] Conjunctival squamous cell carcinoma in a reindeer (Rangifer tarandus tarandus).
  • An 8-year-old female adult reindeer (Rangifer tarandus tarandus) was referred to the Veterinary Hospital of Madrid for evaluation of a conjunctival mass on the left eye which had been present for about 2 months.
  • Follow-up examination at 12 months postsurgery did not reveal recurrence of this neoplasm.
  • Conjunctival squamous cell carcinoma has not been reported previously in reindeer and seems to have similar characteristics to the one existing in bovine species.
  • [MeSH-major] Carcinoma, Squamous Cell / veterinary. Conjunctival Neoplasms / veterinary. Reindeer

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  • [Copyright] © 2012 American College of Veterinary Ophthalmologists.
  • (PMID = 23121493.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Rangifer tarandus tarandus / conjunctiva / conjunctival squamous cell carcinoma / ki67 / p53 protein / reindeer
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25. |||....... 26%  Ranjbar M, Müller M, Neppert B, Brüggemann A: [Prominent conjunctival tumor]. Ophthalmologe; 2013 Mar;110(3):255-8
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  • [Title] [Prominent conjunctival tumor].
  • The case of a 57-year-old woman with a rapidly growing unpigmented conjunctival tumor is presented.
  • Despite the clinical appearance the histology surprisingly confirmed a malignant melanoma of the conjunctiva.
  • Various phenotypes and the rareness of this disease complicate a clinical diagnosis.
  • Therapeutically, a complete excision of the tumor including a safety margin, adjuvant topical chemotherapy and closely monitored follow-up are crucial.
  • [MeSH-major] Chemotherapy, Adjuvant / methods. Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / therapy. Melanoma / pathology. Melanoma / therapy. Ophthalmologic Surgical Procedures / methods

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  • (PMID = 23354355.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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26. |||....... 26%  Rankin JK, Jakobiec FA, Zakka FR, Foster CS: An improved approach to diagnosing and treating conjunctival mucoepidermoid carcinoma. Surv Ophthalmol; 2012 Jul-Aug;57(4):337-46
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  • [Title] An improved approach to diagnosing and treating conjunctival mucoepidermoid carcinoma.
  • The current case of conjunctival mucoepidermoid carcinoma offers features that expand the biologic spectrum afforded by this tumor.
  • Behaviorally aggressive or rapidly recurrent epithelial squamous tumors with "inflammatory" features or unusual clinical characteristics should be initially stained at multiple levels for the detection of parsimonious mucus secretion.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / surgery
  • [MeSH-minor] Carcinoma, Squamous Cell / chemistry. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Eye Enucleation. Female. Humans. Middle Aged. Neoplasm Invasiveness. Tumor Markers, Biological / analysis

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22541742.001).
  • [ISSN] 1879-3304
  • [Journal-full-title] Survey of ophthalmology
  • [ISO-abbreviation] Surv Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Markers, Biological
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27. |||....... 25%  Artornsombudh P, Sanpavat A, Tinnungwattana U, Tongkhomsai V, Sansopha L, Tulvatana W: Prevalence and clinicopathologic findings of conjunctival epithelial neoplasia in pterygia. Ophthalmology; 2013 Jul;120(7):1337-40
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  • [Title] Prevalence and clinicopathologic findings of conjunctival epithelial neoplasia in pterygia.
  • PURPOSE: To study the prevalence of conjunctival neoplasia in clinically diagnosed pterygia and the clinicopathologic characteristics of conjunctival tissues obtained from pterygium excision.
  • Histopathologic results showed that 4 eyes had conjunctival intraepithelial neoplasia.
  • Two eyes had minimal cellular atypia at the conjunctival epithelium.
  • For the subjects who had conjunctival epithelial neoplasia, the mean age was 57.0 ± 8.0 years, 44.4% were male, and none had a history of carcinoma in other organs or any history of herpes virus, human papilloma virus, or human immunodeficiency virus infections.
  • CONCLUSIONS: The prevalence of conjunctival epithelial neoplasia in clinically diagnosed pterygia is approximately 1.8%.
  • Because the clinical characteristics of subjects who have conjunctival epithelial neoplasia apparently did not differ from those without, tissue pathologic examination may be required to diagnose the condition.
  • [MeSH-major] Carcinoma in Situ / epidemiology. Conjunctival Neoplasms / epidemiology. Pterygium / complications

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  • [Copyright] Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
  • (PMID = 23499063.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. |||....... 25%  Rundle P, Mudhar HS, Rennie I: Conjunctival intra-epithelial neoplasia occurring in young patients with asthma. Eye (Lond); 2010 Jul;24(7):1182-5
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  • [Title] Conjunctival intra-epithelial neoplasia occurring in young patients with asthma.
  • BACKGROUND: Conjunctival intra-epithelial neoplasia (CIN) typically occurs in elderly individuals.
  • Five patients showed unilateral disease, whereas two showed bilateral.
  • CONCLUSION: The occurrence of CIN, particularly bilateral CIN, in younger immunocompetent individuals is very unusual, and the presence of asthma in 64% of our patient cohort suggests that atopic asthma may be a further aetiological factor involved in the development of this rare neoplasm.
  • [MeSH-major] Asthma / complications. Conjunctival Neoplasms / etiology
  • [MeSH-minor] Adult. Age Factors. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies


29. |||....... 25%  Shields JA, Kligman BE, Mashayekhi A, Shields CL: Acquired sessile hemangioma of the conjunctiva: a report of 10 cases. Am J Ophthalmol; 2011 Jul;152(1):55-59.e1
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  • [Title] Acquired sessile hemangioma of the conjunctiva: a report of 10 cases.
  • PURPOSE: To report 10 cases of an unusual conjunctival lesion that has been termed acquired sessile hemangioma.
  • METHODS: A chart review was conducted on patients coded as having a conjunctival vascular tumor at the Ocular Oncology Service at Wills Eye Institute, Thomas Jefferson University.
  • A cohort of these patients was identified as having a lesion comprising a complex sessile arrangement of conjunctival blood vessels that were remarkably similar to one another, but were distinctly different from other known conjunctival vascular tumors and malformations.
  • These lesions were called acquired sessile hemangioma of the conjunctiva.
  • Each tumor was assessed for anatomic location in the conjunctiva, quadrant of involvement, diameter, thickness, margin (sharp or ill-defined), and presence of feeder blood vessels.
  • In the other 9 cases, it was a coincidental finding by the authors on referral for unrelated problems.
  • In each case, acquired sessile hemangioma was characterized by a flat array of intertwining, mildly dilated blood vessels, usually on the bulbar conjunctiva.
  • CONCLUSIONS: Acquired sessile hemangioma is an unusual conjunctival vascular lesion of adults that has characteristic clinical features.
  • It should be differentiated from other conjunctival vascular lesions.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Hemangioma, Capillary / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Conjunctiva / blood supply. Conjunctiva / pathology. Female. Fluorescein Angiography. Humans. Male. Middle Aged. Retrospective Studies

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21529766.001).
  • [ISSN] 1879-1891
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. ||........ 25%  Shields CL, Kaliki S, Al-Dahmash SA, Lally SE, Shields JA: American Joint Committee on Cancer (AJCC) clinical classification predicts conjunctival melanoma outcomes. Ophthal Plast Reconstr Surg; 2012 Sep-Oct;28(5):313-23
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  • [Title] American Joint Committee on Cancer (AJCC) clinical classification predicts conjunctival melanoma outcomes.
  • PURPOSE: The aim of this study was to evaluate conjunctival melanoma outcomes based on American Joint Committee on Cancer classification.
  • RESULTS: On the basis of the American Joint Committee on Cancer classification (seventh edition), conjunctival melanoma was classified as T1 (196 [57%]), T2 (110 [32%]), T3 (37 [11%]), and T4 (0).
  • The mean tumor basal diameter increased with tumor staging with 8.5 mm for T1, 12.7 mm for T2 (p = 0.0003), and 16 mm for T3 (p < 0.0001).
  • The melanoma arose from primary acquired melanosis (T1 = 71%; T2 = 84%; T3 = 81%), preexisting nevus (T1 = 8%; T2 = 5%; T3 = 3%), or de novo (T1 = 21%; T2 = 12%; T3 = 16%).
  • Outcomes at 5 years (Kaplan-Meier) revealed melanoma local recurrence/new tumor in 44% T1, 78% T2 (p < 0.0001), and 76% T3 (P=0.0044); regional lymph node metastasis in 17% T1, 52% T2 (p < 0.0001), and 49% T3 (p = 0.0092); melanoma-related distant metastasis in 11% T1, 35% T2 (p < 0.0001), and 42% T3 (p = 0.0018); and melanoma-related death in 5% T1, 20% T2 (p = 0.0655), and 23% T3 (p = 0.0526).
  • After adjusting for tumor origin, factors predictive of regional lymph node metastasis, melanoma-related distant metastasis, and melanoma-related death included melanoma arising de novo (p < 0.0001; p < 0.0001; p < 0.0001), T2 stage (p < 0.0001; p < 0.0001; p = 0.007), and T3 stage (p = 0.005; p = 0.0014; p = 0.0342).
  • CONCLUSION: The American Joint Committee on Cancer staging predicts prognosis of conjunctival melanoma.
  • [MeSH-major] Conjunctival Neoplasms / classification. Conjunctival Neoplasms / pathology. Melanoma / classification. Melanoma / secondary
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Medical Oncology / organization & administration. Middle Aged. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Factors. Survival Rate. United States. Young Adult


31. ||........ 25%  Baumüller S, Kosanetzky N, Charbel Issa P, Holz FG, Löffler KU: [Vascular lesion of the conjunctiva]. Ophthalmologe; 2009 Sep;106(9):832-5
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  • [Title] [Vascular lesion of the conjunctiva].
  • [Transliterated title] Vaskuläre Läsion der Bindehaut.
  • Based on the results of the early indocyanine green angiography, MRI and sonography, a racemose hemangioma of the conjunctiva was diagnosed.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / therapy. Hemangioma / diagnosis. Hemangioma / therapy

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  • (PMID = 19557417.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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32. ||........ 24%  Nelson KD, McSoley JJ: Clinical findings and management of conjunctival intraepithelial neoplasia. Optometry; 2011 Jan;82(1):15-21
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  • [Title] Clinical findings and management of conjunctival intraepithelial neoplasia.
  • BACKGROUND: Conjunctival intraepithelial neoplasia (CIN) is the most common tumor of the ocular surface and is a precursor to invasive squamous cell carcinoma.
  • CIN comprises a spectrum of premalignant epithelial neoplasia that usually begins near the limbus and spreads to the cornea.
  • METHODS: This case report reviews the clinical findings and management of CIN, with a discussion of the histopathology and etiology of this tumor.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Conjunctival Neoplasms / diagnosis. Cryotherapy / methods

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  • [Copyright] Copyright © 2010 American Optometric Association. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21071282.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. ||........ 24%  Halas JM, Svetlosakova Z, Babal P: Therapy of melanocytic conjunctival tumors. Bratisl Lek Listy; 2013;114(8):446-50
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  • [Title] Therapy of melanocytic conjunctival tumors.
  • BACKGROUND: Clinical experience of our single center in dealing with pigmented epibulbar lesions - melanocytic conjunctival tumors is presented.
  • Since 2008 we use the topical treatment with mitomycin C (MMC) as an alternative or adjunctive method for excision in the treatment of melanocytic neoplasia of the conjunctiva.
  • METHODS: The retrospective case series of 85 patients with pigmented lesions of the conjunctiva - melanocytic conjunctival tumors, histopathologically examined in the period 2001-2010 is presented.
  • RESULTS: In 85 patients with pigmented lesions of the conjunctiva histopathological findings after excision of the lesion showed in 68 (80 %) cases melanocytic nevocelullar nevus, out of which 55 cases were combined and 13 cases were junctional nevi.
  • During the period of application of MMC we diagnosed only one patient with primary conjunctival melanoma.
  • CONCLUSION: Resection of more than one quadrant of bulbar conjunctiva in patients with pigmented lesions of the conjunctiva in cases of conjunctival nevus with atypia and PAM with atypia combined with topical MMC chemotherapy is an alternative therapy for residual pigmented lesions.
  • [MeSH-major] Conjunctival Neoplasms / therapy. Melanoma / therapy. Melanosis / therapy. Nevus, Pigmented / therapy

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  • (PMID = 23944618.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovakia
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34. ||........ 24%  Shields CL, Regillo AC, Mellen PL, Kaliki S, Lally SE, Shields JA: Giant conjunctival nevus: clinical features and natural course in 32 cases. JAMA Ophthalmol; 2013 Jul;131(7):857-63
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  • [Title] Giant conjunctival nevus: clinical features and natural course in 32 cases.
  • IMPORTANCE: Conjunctival nevus is the most common tumor of the ocular surface and we selected the largest nevi to evaluate for clinical features and outcomes.
  • OBJECTIVE: To describe the clinical features and outcomes of giant (≥10 mm diameter) conjunctival nevus.
  • DESIGN, SETTING, AND PATIENTS: Retrospective case series of 618 patients with conjunctival nevus, 32 of which had giant conjunctival nevus, treated at an ocular oncology service between July 1, 1974, and June 30, 2012.
  • RESULTS: Of 618 patients with conjunctival nevus, 32 (5%) were classified as having giant conjunctival nevus.
  • Of those with giant conjunctival nevus, a history of an increase in nevus base or thickness was noted in 15 cases (47%) and an increase in color intensity in 2 cases (6%).
  • The giant nevus involved cornea in 11 cases (34%), limbus in 23 (72%), bulbar conjunctiva in 31 (97%), fornix in 9 (28%), tarsus in 3 (9%), semilunar fold in 10 (31%), and caruncle in 7 (22%).
  • CONCLUSIONS AND RELEVANCE: In an ocular oncology practice, giant conjunctival nevus represents 5% of conjunctival nevi.
  • This benign tumor rarely transforms into conjunctival melanoma.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Nevus, Pigmented / diagnosis

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  • (PMID = 23702735.001).
  • [ISSN] 2168-6173
  • [Journal-full-title] JAMA ophthalmology
  • [ISO-abbreviation] JAMA Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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35. ||........ 24%  Olbertz L, Lima L, Langohr I, Werner J, Teixeira L, Montiani-Ferreira F: Supposed primary conjunctival lymphoma in a dog. Vet Ophthalmol; 2013 Jul;16 Suppl 1:100-4
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  • [Title] Supposed primary conjunctival lymphoma in a dog.
  • A 7-year-old, male mixed-breed dog was presented for evaluation of a well-delineated, pink, oval and slightly firm mass with a smooth regular surface that was expanding approximately 60% of the lower eyelid conjunctiva and the lateral canthus.
  • The dog had a supposed primary B-cell lymphoma at the temporal canthus of the upper eyelid conjunctiva of the same eye that had been removed approximately 3 years earlier.
  • Histologically, the conjunctival lamina propria was effaced by a well-delineated, unencapsulated and expansile highly cellular neoplasm composed of sheets of round cells that were immunohistochemically positive for CD20 and CD79a negative for CD3.
  • Based on the microscopic and immunohistochemical findings, a diagnosis of supposed primary B cell conjunctival lymphoma was made.
  • Further tumor recurrence was not observed one year post operatively.
  • This case was considered unusual because of its conjunctival involvement and the clinical course with recurrence after three years of a surgical therapeutic procedure.
  • [MeSH-major] Conjunctival Neoplasms / veterinary. Dog Diseases / pathology. Lymphoma / veterinary

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  • [Copyright] © 2012 American College of Veterinary Ophthalmologists.
  • (PMID = 22524231.001).
  • [ISSN] 1463-5224
  • [Journal-full-title] Veterinary ophthalmology
  • [ISO-abbreviation] Vet Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; conjunctival neoplasm / dog / immunohistochemistry / lymphoma
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36. ||........ 24%  Ciralsky J, Colby K: Conjunctival melanomas: can the cancer stem cell hypothesis be applied? Semin Ophthalmol; 2009 May-Jun;24(3):161-5
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  • [Title] Conjunctival melanomas: can the cancer stem cell hypothesis be applied?
  • Conjunctival melanoma patients often follow an unpredictable course with significant rates of recurrence and metastases despite optimal treatment.
  • Can we better understand conjunctival melanomas by applying the cancer stem cell hypothesis?
  • The cancer stem cell hypothesis posits that cancers exist as a hierarchical system where cancer stem cells generate and maintain tumors.
  • [MeSH-major] Conjunctival Neoplasms / etiology. Melanoma / etiology. Neoplastic Stem Cells / physiology

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  • (PMID = 19437352.001).
  • [ISSN] 1744-5205
  • [Journal-full-title] Seminars in ophthalmology
  • [ISO-abbreviation] Semin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents
  • [Number-of-references] 31
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37. ||........ 24%  Triay E, Bergman L, Nilsson B, All-Ericsson C, Seregard S: Time trends in the incidence of conjunctival melanoma in Sweden. Br J Ophthalmol; 2009 Nov;93(11):1524-8
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  • [Title] Time trends in the incidence of conjunctival melanoma in Sweden.
  • AIM: To study time trends in the incidence of conjunctival melanoma in Sweden.
  • METHODS: All patients with conjunctival melanoma from 1960 to 2005 in Sweden were identified through the Swedish Cancer Registry, cross-checked against hospital files, and validated by histopathological review (97.5%) or detailed hospital records (2.5%).
  • Time trends for the largest diameter, thickness and location of the tumour when diagnosed were analysed.
  • RESULTS: The age-standardised incidence of conjunctival melanoma increased significantly in men (n = 89) from 0.10 cases/million to 0.74 cases/million (p = 0.001) and in women (n = 81) from 0.06 cases/million to 0.45 cases/million (p = 0.007).
  • During the period of study, tumours became smaller (p = 0.005) and thinner (p = 0.002) at the time of diagnosis and increasingly arose from parts of the conjunctiva exposed to ultraviolet radiation (p = 0.001).
  • CONCLUSION: The incidence of conjunctival melanoma increased in Sweden during the period 1960 to 2005.
  • [MeSH-major] Conjunctival Neoplasms / epidemiology. Melanoma / epidemiology

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  • (PMID = 19628487.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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38. ||........ 24%  Damato B, Coupland SE: An audit of conjunctival melanoma treatment in Liverpool. Eye (Lond); 2009 Apr;23(4):801-9
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  • [Title] An audit of conjunctival melanoma treatment in Liverpool.
  • PURPOSE: To evaluate treatment of conjunctival melanomas at the Ocular Oncology Service in Liverpool.
  • METHODS: We included 40 patients initially treated at our centre for invasive conjunctival melanoma and 36 patients referred for salvage therapy after surgery elsewhere.
  • Adjunctive cryotherapy for invasive and intra-epithelial neoplasia was abandoned in favour of ruthenium brachytherapy and mitomycin C chemotherapy, respectively.
  • RESULTS: The 40 previously-untreated tumours were confined to bulbar conjunctiva in 31 patients and involved extrabulbar conjunctiva in 9, affecting caruncle in 6 of these.
  • Invasive conjunctival recurrence, which occurred in six patients, was more likely with medial tumours (Log-rank, P=0.004) and if treatment did not include radiotherapy (Log-rank, P=0.03).
  • Of the 36 patients referred for salvage therapy after previous surgery, 11 had no visible tumour, 9 had only intra-epithelial neoplasia, and 16 had invasive melanoma, which was recurrent in seven.
  • After salvage therapy, five patients died, all of whom were referred with recurrent invasive tumour and only one of whom had caruncular involvement.
  • CONCLUSIONS: Excision of invasive melanoma with adjunctive brachytherapy and topical chemotherapy achieved high rates of local tumour control with little ocular morbidity.
  • Without caruncular involvement, disease-specific mortality was rare unless the patient was referred after a surgical procedure.
  • [MeSH-major] Conjunctival Neoplasms / therapy. Melanoma / therapy
  • [MeSH-minor] Administration, Topical. Adult. Aged. Aged, 80 and over. Antibiotics, Antineoplastic / therapeutic use. Brachytherapy / methods. Clinical Audit. Cryotherapy. England. Female. Humans. Male. Middle Aged. Mitomycin / therapeutic use. Neoplasm Recurrence, Local. Visual Acuity. Young Adult

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  • (PMID = 18535601.001).
  • [ISSN] 1476-5454
  • [Journal-full-title] Eye (London, England)
  • [ISO-abbreviation] Eye (Lond)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
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39. ||........ 24%  Ichhpujani P, Barahimi B, Shields CL, Eagle RC Jr, Katz LJ: Canaloplasty for pigmentary glaucoma with coexisting conjunctival lymphoma. Ophthalmic Surg Lasers Imaging; 2011;42 Online:e10-1
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  • [Title] Canaloplasty for pigmentary glaucoma with coexisting conjunctival lymphoma.
  • This case report presents canaloplasty as a bleb-free surgical option for lowering intraocular pressure in cases with postoperative conjunctival scarring.
  • [MeSH-minor] Aged. Combined Modality Therapy. Conjunctival Neoplasms / complications. Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / surgery. Cryotherapy. Humans. Intraocular Pressure. Male. Sclera / surgery. Surgical Flaps. Visual Acuity

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  • [Copyright] Copyright 2011, SLACK Incorporated.
  • (PMID = 21323187.001).
  • [ISSN] 1938-2375
  • [Journal-full-title] Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye
  • [ISO-abbreviation] Ophthalmic Surg Lasers Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. ||........ 23%  Jakobiec FA, Mendoza PR, Colby KA: Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma. Am J Ophthalmol; 2013 Oct;156(4):830-46
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  • [Title] Clinicopathologic and immunohistochemical studies of conjunctival large cell acanthoma, epidermoid dysplasia, and squamous papilloma.
  • PURPOSE: To evaluate clinicopathologically and immunohistochemically a spectrum of conjunctival squamous proliferations.
  • Normal associated conjunctiva served as a baseline for interpretation.
  • The cells were 2-3 times larger than the keratinocytes of the normal conjunctiva and did not display atypia.
  • Immunohistochemistry revealed a low Ki-67 proliferation index (PI) in the large cell acanthoma compared with high indices in dysplasias and papillomas. p53 was negative in the nuclei of normal epithelium while positive in all neoplasms, most intensely in the dysplasias.
  • Immunostaining showed similar staining patterns for cytokeratins in large cell acanthoma and normal conjunctiva, except for full-thickness CK14 positivity and CK7 negativity in the lesion.
  • CONCLUSIONS: Conjunctival large cell acanthoma is a morphologically distinctive clonal entity with clinical and immunohistochemical phenotypic characteristics denoting a dysplasia of minimal severity.
  • [MeSH-major] Acanthoma / pathology. Carcinoma in Situ / pathology. Conjunctival Neoplasms / chemistry. Conjunctival Neoplasms / pathology. Papilloma / pathology. Tumor Markers, Biological / analysis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, Neoplasm / analysis. Female. Humans. Immunoenzyme Techniques. Male. Middle Aged. Neoplasm Proteins / analysis. Neoplasm Recurrence, Local / diagnosis. Paraffin Embedding. Retrospective Studies

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23786782.001).
  • [ISSN] 1879-1891
  • [Journal-full-title] American journal of ophthalmology
  • [ISO-abbreviation] Am. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Neoplasm Proteins; 0 / Tumor Markers, Biological
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41. ||........ 23%  Jakobiec FA, Sandhu H, Bhat P, Colby K: Bilateral conjunctival melanocytic nevi of simultaneous onset simulating conjunctivitis in a child. Cornea; 2010 Aug;29(8):937-40
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  • [Title] Bilateral conjunctival melanocytic nevi of simultaneous onset simulating conjunctivitis in a child.
  • Finely vascularized, minimally elevated, amelanotic or faintly focally pigmented, epibulbar conjunctival lesions were present bilaterally.
  • Juvenile conjunctival nevi frequently have atypical histopathologic traits that in an adult could be suggestive of melanoma.
  • The differential diagnosis of much less likely disorders includes leukemia, lymphoid tumor (salmon patch), and conjunctival sarcoidosis, among other conditions.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Conjunctivitis / diagnosis. Nevus, Pigmented / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Female. Functional Laterality. Humans. Tumor Markers, Biological / metabolism. Visual Acuity / physiology

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  • (PMID = 20508514.001).
  • [ISSN] 1536-4798
  • [Journal-full-title] Cornea
  • [ISO-abbreviation] Cornea
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Markers, Biological
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42. ||........ 23%  Oellers P, Karp CL: Management of pigmented conjunctival lesions. Ocul Surf; 2012 Oct;10(4):251-63
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  • [Title] Management of pigmented conjunctival lesions.
  • Pigmented conjunctival lesions primarily include melanoma, nevus, primary acquired melanosis (PAM), and complexion-associated melanosis.
  • The incidence of conjunctival malignant melanoma (CMM) has significantly increased in the USA and Europe over the years, and it carries a very serious risk for metastasis and melanoma-related death.
  • Conjunctival melanoma can arise de novo or from precursor lesions, nevus, and PAM.
  • Nevus is a benign melanocytic tumor that only rarely undergoes malignant transformation.
  • A detailed literature review on the various pigmented conjunctival lesions together with a schematic approach to diagnosis and management is presented.
  • [MeSH-major] Conjunctival Neoplasms / therapy. Melanoma / therapy. Melanosis / therapy. Nevus, Pigmented / therapy

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 23084146.001).
  • [ISSN] 1937-5913
  • [Journal-full-title] The ocular surface
  • [ISO-abbreviation] Ocul Surf
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30EY014801
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
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43. ||........ 23%  Esmaeli B, Roberts D, Ross M, Fellman M, Cruz H, Kim SK, Prieto VG: Histologic features of conjunctival melanoma predictive of metastasis and death (an American Ophthalmological thesis). Trans Am Ophthalmol Soc; 2012 Dec;110:64-73
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  • [Title] Histologic features of conjunctival melanoma predictive of metastasis and death (an American Ophthalmological thesis).
  • PURPOSE: In conjunctival melanoma, tumor thickness and nonlimbal location are associated with poor prognosis.
  • However, other established high-risk features for cutaneous melanoma, including ulceration, mitotic figures, epithelioid cell type, and lymphovascular invasion, have not previously been studied extensively for their prognostic value in conjunctival melanoma.
  • We examined the hypothesis that these features also predict regional nodal metastasis and death in conjunctival melanoma.
  • METHODS: The medical records of 44 of 46 consecutive conjunctival melanoma patients treated between June 2003 and December 2009 were retrospectively reviewed; tumor tissue was not available for the two excluded patients.
  • Demographic and clinicopathologic features, including tumor location, tumor thickness, ulceration, mitotic rate, histology, lymphovascular invasion, and microsatellitosis, were reviewed.
  • At last follow-up, 10 patients (23%) had died of disease.
  • Tumor thickness>2.0 mm, ulceration, and mitotic figure>1/mm2 predicted regional nodal metastasis and death from disease.
  • In addition to these three histologic features, vascular invasion, epithelioid cell type, and microsatellitosis significantly predicted death from disease.
  • Tumor location (bulbar vs nonbulbar) was not correlated with regional nodal metastasis or death.
  • CONCLUSIONS: In conjunctival melanoma, as in cutaneous melanoma, thicker tumor, ulceration, and higher mitotic rate are correlated with regional nodal metastasis.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Melanoma / pathology
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • [Cites] Ophthalmology. 2009 Nov;116(11):2217-23 [19766318.001]
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  • (PMID = 23818735.001).
  • [ISSN] 1545-6110
  • [Journal-full-title] Transactions of the American Ophthalmological Society
  • [ISO-abbreviation] Trans Am Ophthalmol Soc
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA016672; United States / NCI NIH HHS / CA / P30 CA016672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3671367
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44. ||........ 23%  Kirwan C, Ngan BY, Halliday W, Alexander S, Ali A: Primary conjunctival anaplastic large cell lymphoma in a child. J AAPOS; 2013 Aug;17(4):437-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary conjunctival anaplastic large cell lymphoma in a child.
  • Conjunctival tumors in children are uncommon and behave differently from those in adults.
  • The vast majority of tumors are benign.
  • Most lymphoid tumors in children represent lymphoid hyperplasia, not lymphoma.
  • We present an unusual case of primary anaplastic large cell lymphoma of the conjunctiva in a young boy.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Lymphoma, Large-Cell, Anaplastic / pathology

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  • [Copyright] Copyright © 2013. Published by Mosby, Inc.
  • (PMID = 23896363.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. ||........ 23%  Jain RK, Mehta R, Badve S: Conjunctival squamous cell carcinoma due to ocular prostheses: a case report and review of literature. Pathol Oncol Res; 2010 Dec;16(4):609-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival squamous cell carcinoma due to ocular prostheses: a case report and review of literature.
  • Conjunctival squamous cell carcinoma (SCC) is a rare finding in everyday clinical practice, but is the most common malignancy of the ocular surface.
  • It is one extreme of a spectrum of lesions encompassed in ocular surface squamous neoplasia which range from dysplasia to carcinoma in situ to invasive SCC.
  • Herein we report a case of SCC arising in chronic conjunctival irritation due to prolonged prosthetic use following enucleation for traumatic eye injury.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Conjunctival Neoplasms / etiology. Eye, Artificial / adverse effects
  • [MeSH-minor] Conjunctiva / pathology. Conjunctiva / surgery. Histocytochemistry. Humans. Male. Middle Aged


46. ||........ 23%  Damato B, Coupland SE: Management of conjunctival melanoma. Expert Rev Anticancer Ther; 2009 Sep;9(9):1227-39
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of conjunctival melanoma.
  • Invasive conjunctival melanoma can arise de novo, from nevus or from melanoma in situ.
  • The literature reports that after treatment of invasive conjunctival melanoma more than 50% of patients develop local tumor recurrence, with 20% eventually requiring orbital exenteration and 20-30% developing fatal metastasis.
  • There is scope for multicenter clinical trials and translational research, but these require consistent staging and grading of disease.
  • We have devised a clinical system for mapping conjunctival melanocytic lesions and a system for scoring the histological grade of atypia of conjunctival melanocytic intra-epithelial neoplasia/melanoma in situ.
  • We anticipate that these measures will improve outcomes after treatment of conjunctival melanoma in situ and invasive melanoma.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Conjunctival Neoplasms / therapy. Melanoma / therapy
  • [MeSH-minor] Administration, Topical. Clinical Trials as Topic. Combined Modality Therapy. Cryotherapy / methods. Humans. Neoplasm Invasiveness. Neoplasm Recurrence, Local. Treatment Outcome

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  • (PMID = 19761427.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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47. ||........ 23%  Fukuhara J, Kase S, Noda M, Ishijima K, Yamamoto T, Ishida S: Conjunctival lymphoma arising from reactive lymphoid hyperplasia. World J Surg Oncol; 2012;10:194
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conjunctival lymphoma arising from reactive lymphoid hyperplasia.
  • Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue.
  • The pathogenesis of conjunctival EMZL remains unknown.
  • We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva.
  • A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU).
  • Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma.
  • The tumors were histologically diagnosed as RLH OD, and EMZL OS.
  • This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Lymphoma, B-Cell, Marginal Zone / pathology. Pseudolymphoma / pathology

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  • (PMID = 22985187.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3499207
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48. ||........ 23%  Fino P, Onesti MG, Fioramonti P, Romanzi A, Scuderi N: First reported case of primary basal cell carcinoma of the right caruncle: a case report and review of the literature. In Vivo; 2013 Jul-Aug;27(4):535-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: The clinical and histopathological characteristics of a patient with a primary basal cell carcinoma (BCC) of the right caruncle without seeding of the tumor to the conjunctiva are described.
  • The tumour was completely excised.
  • CONCLUSION: This case describes a primary BCC of the right caruncle without seeding to the conjunctiva.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Conjunctival Neoplasms / diagnosis

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  • (PMID = 23812227.001).
  • [ISSN] 1791-7549
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Greece
  • [Keywords] NOTNLM ; Basal cell carcinoma / caruncle / ocular tumor
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49. ||........ 23%  Lin HC, Chu PH, Jung SM, Yang ML, Ma DH: MUC5AC in juvenile conjunctival nevus. Jpn J Ophthalmol; 2012 Mar;56(2):107-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MUC5AC in juvenile conjunctival nevus.
  • PURPOSE: To evaluate the possible role of cysts with mucins and inflammatory cells in rapid-growing juvenile conjunctival nevus.
  • Seventeen conjunctival melanocytic lesions surgically excised from patients aged <20 years between 2001 and 2009 were examined by hematoxylin-eosin, periodic acid-Schiff, MUC5AC, and Alcian blue staining.
  • RESULTS: Eleven patients (3 girls and 8 boys; mean age 13.72 ± 3.60 years) underwent excision of a conjunctival nevus that had grown rapidly within a recent 6-month period.
  • CONCLUSIONS: The period of rapid growth of juvenile conjunctival nevus is not a malignant clinical sign.
  • [MeSH-major] Conjunctival Neoplasms / metabolism. Mucin 5AC / metabolism. Nevus, Pigmented / metabolism

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  • (PMID = 22139382.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / MUC5AC protein, human; 0 / Mucin 5AC
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50. ||........ 23%  Cohen VM, Tsimpida M, Hungerford JL, Jan H, Cerio R, Moir G: Prospective study of sentinel lymph node biopsy for conjunctival melanoma. Br J Ophthalmol; 2013 Dec;97(12):1525-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prospective study of sentinel lymph node biopsy for conjunctival melanoma.
  • BACKGROUND: To report our experience with sentinel lymph node biopsy for staging patients with conjunctival melanoma.
  • METHODS: A prospective review of patients with conjunctival melanoma who underwent sentinel lymph node biopsy at St Bartholomew's Hospital from May 2008 to May 2012.
  • The selection criterion for sentinel node biopsy depended on the tumour thickness (≥2 mm) and location of the conjunctival melanoma.
  • It should be considered for the staging of conjunctival melanomas, especially melanomas in non-limbal location or conjunctival melanomas ≥2 mm thick.
  • [MeSH-major] Conjunctival Neoplasms / pathology. Conjunctival Neoplasms / radionuclide imaging. Melanoma / radionuclide imaging. Melanoma / secondary. Sentinel Lymph Node Biopsy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Enzyme Inhibitors / diagnostic use. Female. Follow-Up Studies. Humans. Incidence. Male. Methylene Blue / diagnostic use. Middle Aged. Neoplasm Staging. Prevalence. Prospective Studies. Technetium / diagnostic use. Young Adult

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  • (PMID = 24064944.001).
  • [ISSN] 1468-2079
  • [Journal-full-title] The British journal of ophthalmology
  • [ISO-abbreviation] Br J Ophthalmol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 7440-26-8 / Technetium; T42P99266K / Methylene Blue
  • [Other-IDs] NLM/ PMC3841742
  • [Keywords] NOTNLM ; Conjunctiva / Neoplasia
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