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1. Biomedical articles (top 50; 2010 to 2015)
3. Hühn MH, McCartney SA, Lind K, Svedin E, Colonna M, Flodström-Tullberg M: Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection. Virology; 2010 May 25;401(1):42-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.
  • Coxsackievirus infections are associated with severe diseases such as myocarditis, meningitis and pancreatitis.
  • To study the contribution of the intracellular viral sensor melanoma differentiation-associated protein-5 (MDA-5) in the host immune response to Coxsackievirus B3 (CVB3) we infected C57BL/6 and 129/SvJ mice lacking mda-5.
  • Mice deficient in MDA-5 showed a dramatically increased susceptibility to CVB3 infection.
  • The loss of MDA-5 allowed the virus to replicate faster, resulting in increased liver and pancreas damage and heightened mortality.
  • MDA-5 was not absolutely required for the induction of type 1 interferons (IFNs), but essential for the production of maximal levels of systemic IFN-alpha early after infection.
  • Taken together, our findings indicate that MDA-5 plays an important role in the host immune response to CVB3 by preventing early virus replication and limiting tissue pathology.
  • [MeSH-major] Coxsackievirus Infections / immunology. Coxsackievirus Infections / virology. DEAD-box RNA Helicases / physiology. Enterovirus / physiology. Virus Replication
  • [MeSH-minor] Animals. Interferon Type I / biosynthesis. Mice. Mice, Inbred C57BL. Mice, Knockout. Virus Attachment

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  • (PMID = 20206372.001).
  • [ISSN] 1096-0341
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / F30HL096354
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon Type I; EC 3.6.1.- / Ifih1 protein, mouse; EC 3.6.4.13 / DEAD-box RNA Helicases
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4. Pedrosa PB, Cardoso TA: Viral infections in workers in hospital and research laboratory settings: a comparative review of infection modes and respective biosafety aspects. Int J Infect Dis; 2011 Jun;15(6):e366-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Viral infections in workers in hospital and research laboratory settings: a comparative review of infection modes and respective biosafety aspects.
  • OBJECTIVES: To compare modes and sources of infection and clinical and biosafety aspects of accidental viral infections in hospital workers and research laboratory staff reported in scientific articles.
  • METHODS: PubMed, Google Scholar, ISI Web of Knowledge, Scirus, and Scielo were searched (to December 2008) for reports of accidental viral infections, written in English, Portuguese, Spanish, or German; the authors' personal file of scientific articles and references from the articles retrieved in the initial search were also used.
  • Systematic review was carried out with inclusion criteria of presence of accidental viral infection's cases information, and exclusion criteria of absence of information about the viral etiology, and at least probable mode of infection.
  • For arboviruses, 84% of the laboratory infections had aerosol as the source; for alphaviruses alone, aerosol exposure accounted for 94% of accidental infections.
  • Of laboratory arboviral infections, 15.7% were acquired percutaneously, whereas 41.6% of hospital infections were percutaneous.
  • For airborne viruses, 81% of the infections occurred in laboratories, with hantavirus the leading causative agent.
  • Aerosol inhalation was implicated in 96% of lymphocytic choriomeningitis virus infections, 99% of hantavirus infections, and 50% of coxsackievirus infections, but infective droplet inhalation was the leading mode of infection for severe acute respiratory syndrome coronavirus and the mucocutaneous mode of infection was involved in the case of infection with influenza B.
  • For blood-borne viruses, 92% of infections occurred in hospitals and 93% of these had percutaneous mode of infection, while among laboratory infections 77% were due to infective aerosol inhalation.
  • Among blood-borne virus infections there were six cases of particular note: three cases of acute hepatitis following hepatitis C virus infection with a short period of incubation, one laboratory case of human immunodeficiency virus infection through aerosol inhalation, one case of hepatitis following hepatitis G virus infection, and one case of fulminant hepatitis with hepatitis B virus infection following exposure of the worker's conjunctiva to hepatitis B virus e antigen-negative patient saliva.
  • Of the 12 infections with viruses with preferential mucocutaneous transmission, seven occurred percutaneously, aerosol was implicated as a possible source of infection in two cases, and one atypical infection with Macacine herpesvirus 1 with fatal encephalitis as the outcome occurred through a louse bite.
  • One outbreak of norovirus infection among hospital staff had as its probable mode of infection the ingestion of inocula spread in the environment by fomites.
  • CONCLUSIONS: The currently accepted and practiced risk analysis of accidental viral infections based on the conventional dynamics of infection of the etiological agents is insufficient to cope with accidental viral infections in laboratories and to a lesser extent in hospitals, where unconventional modes of infection are less frequently present but still have relevant clinical and potential epidemiological consequences.
  • Unconventional modes of infection, atypical clinical development, or extremely severe cases are frequently present together with high viral loads and high virulence of the agents manipulated in laboratories.
  • Current standard precaution practices are insufficient to prevent most of the unconventional infections in hospitals analyzed in this study; it is recommended that special attention be given to flaviviruses in these settings.
  • [MeSH-major] Containment of Biohazards / methods. Health Personnel / statistics & numerical data. Laboratory Infection / transmission. Medical Laboratory Personnel / statistics & numerical data. Virus Diseases / transmission
  • [MeSH-minor] Accidents, Occupational. Cross Infection / epidemiology. Cross Infection / transmission. Cross Infection / virology. Humans. Occupational Exposure. Research. Risk Assessment

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  • [Copyright] Copyright © 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21497126.001).
  • [ISSN] 1878-3511
  • [Journal-full-title] International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • [ISO-abbreviation] Int. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Canada
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5. Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Coxsackie Disease': Top Publications. BioMedLib Review; DiseaseOrSyndrome;CoxsackieDisease:707066492. ISSN: 2331-5717. 2014/2/4
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  • [Title] 'Diseases or Syndromes' associated with 'Coxsackie Disease': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'coxsackie disease'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 29 publications, and group two 2131 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Steroids' associated with 'Coxsackie Disease': Top Publications.
  • Fechner H et al: Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections.
  • Hühn MH et al: Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.
  • Yamayoshi S et al: Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71.
  • Jurgeit A et al: An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections.
  • Nomura H et al: Case of hand, foot and mouth disease by Coxsackie virus A6 infection mimicking disseminated herpes zoster.
  • Yan XF et al: Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: Enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16.
  • Lee J et al: An ex vivo model of coxsackievirus infection using multilayered human conjunctival epithelial cells.
  • : [Group enterovirus infection due to coxsackievirus A16 in Northwestern Russia].
  • Tabor-Godwin JM et al: The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707066492.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. Lee CJ, Huang YC, Yang S, Tsao KC, Chen CJ, Hsieh YC, Chiu CH, Lin TY: Clinical features of coxsackievirus A4, B3 and B4 infections in children. PLoS One; 2014;9(2):e87391
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical features of coxsackievirus A4, B3 and B4 infections in children.
  • BACKGROUND: Clinical features of coxsackievirus A4 (CA4), B3 (CB3) and B4 (CB4) infections in children have not been comprehensively described.
  • METHODS/PRINCIPAL FINDINGS: From January 2004 to June 2012, a total of 386 children with culture-proven CA4, CB3 and CB4 infections treated at Chang Gung Memorial Hospital, including 296 inpatients (CA4, 103; CB3, 131; CB4, 62) and 90 outpatients (CA4, 55; CB3, 14; CB4, 21), were included.
  • Children with CB3 infection were youngest (76.6% <3 years of age), and had a highest hospitalization rate (90.3%) and a longest duration of hospitalization (mean ± SD, 7.5 ± 6.2 days).
  • Herpangina (74.8%) was the most common presentation for children with CA4 infection, aseptic meningitis (26.7%) and young infant with fever (23.7%) for those with CB3 infection, and herpangina (32.3%) and tonsillitis/pharyngitis (27.4%) for children with CB4 infection.
  • Twelve out of thirteen (92.3%) children with complications and ten of 11 children with long-term sequelae had CB3 infections.
  • Two fatal cases were noted, one due to myocarditis with CA4 infection and CB3 were detected from the other case which had hepatic necrosis with coagulopathy.
  • CONCLUSION: CA4, CB3 and CB4 infections in children had different clinical disease spectrums and involved different age groups.
  • Though rare, severe diseases may occur, particularly caused by CB3.
  • [MeSH-major] Coxsackievirus Infections / virology. Enterovirus B, Human / physiology

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  • (PMID = 24504149.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3913601
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7. Burke JD, Sonenberg N, Platanias LC, Fish EN: Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3. Antivir Ther; 2011;16(4):577-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.
  • BACKGROUND: Viral myocarditis is most frequently associated with infection by Coxsackievirus B3 (CVB3).
  • METHODS: In the present study we have investigated the role of translational suppression in the context of an IFN-α/β-mediated antiviral immune response to CVB3 infection.
  • Extending these in vitro studies, we examined the effects of CVB3 infection and IFN-β treatment in 4E-BP1(-/-) mice.
  • Similarly, 4E-BP1(-/-) mice are more sensitive to treatment with IFN-β, exhibiting lower viral titres in heart tissue than 4E-BP1(+/+) mice during the course of infection.
  • [MeSH-major] Coxsackievirus Infections / drug therapy

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  • (PMID = 21685545.001).
  • [ISSN] 2040-2058
  • [Journal-full-title] Antiviral therapy
  • [ISO-abbreviation] Antivir. Ther. (Lond.)
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA77816; Canada / Canadian Institutes of Health Research / / MOP 15094; United States / NCI NIH HHS / CA / R01 CA077816; United States / NCI NIH HHS / CA / R01 CA077816-12
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / Carrier Proteins; 0 / Eif4ebp1 protein, mouse; 0 / Phosphoproteins; 77238-31-4 / Interferon-beta
  • [Other-IDs] NLM/ NIHMS306798; NLM/ PMC3142995
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8. Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R: A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J Neurosci; 2010 Jun 23;30(25):8676-91
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  • [Title] A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS.
  • Enterovirus infection in newborn infants is a significant cause of aseptic meningitis and encephalitis.
  • Using a neonatal mouse model, we previously determined that coxsackievirus B3 (CVB3) preferentially targets proliferating neural stem cells located in the subventricular zone within 24 h after infection.
  • At later time points, immature neuroblasts, and eventually mature neurons, were infected as determined by expression of high levels of viral protein.
  • Here, we show that blood-derived Mac3(+) mononuclear cells were rapidly recruited to the CNS within 12 h after intracranial infection with CVB3.
  • These cells displayed a myeloid-like morphology, were of a peripheral origin based on green fluorescent protein (GFP)-tagged adoptive cell transplant examination, and were highly susceptible to CVB3 infection during their migration into the CNS.
  • The recruitment of these novel myeloid cells may be specifically set in motion by the induction of a unique chemokine profile in the CNS induced very early after CVB3 infection, which includes upregulation of CCL12.
  • We propose that intracranial CVB3 infection may lead to the recruitment of nestin(+) myeloid cells into the CNS which might represent an intrinsic host CNS repair response.
  • In turn, the proliferative and metabolic status of recruited myeloid cells may render them attractive targets for CVB3 infection.
  • Moreover, the migratory ability of these myeloid cells may point to a productive method of virus dissemination within the CNS.
  • [MeSH-major] Coxsackievirus Infections / virology. Myeloid Cells / virology

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  • (PMID = 20573913.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI-42314; United States / NIAID NIH HHS / AI / R01 AI042314; United States / NINDS NIH HHS / NS / R01 NS051247; United States / NINDS NIH HHS / NS / R01 NS051247; United States / NINDS NIH HHS / NS / R01 NS054108; United States / NINDS NIH HHS / NS / R01 NS054108; United States / NINDS NIH HHS / NS / R01 NS054108-01A2; United States / NINDS NIH HHS / NS / R01 NS054108-01A2S1; United States / NINDS NIH HHS / NS / R01 NS054108-02; United States / NINDS NIH HHS / NS / R01 NS054108-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS216052; NLM/ PMC2902258
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9. Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Cardiac Infections': Top Publications. BioMedLib Review; DiseaseOrSyndrome;CardiacInfections:707154027. ISSN: 2331-5717. 2014/8/5
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  • [Title] 'Diseases or Syndromes' associated with 'Cardiac Infections': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'cardiac infections'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 44 publications, and group two 3386 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Steroids' associated with 'Cardiac Infections': Top Publications.
  • Viola GM et al: Nonstaphylococcal infections of cardiac implantable electronic devices.
  • Romeyer-Bouchard C et al: Prevalence and risk factors related to infections of cardiac resynchronization therapy devices.
  • Durante Mangoni E et al: [Management of infections from cardiac implantable electronic devices: recommendations from a study panel].
  • Erba PA et al: FDG-PET in cardiac infections.
  • Stanisławska M: [Monitoring of hospital infections in cardiac surgery ward].
  • Zou T et al: Subclinical infections of cardiac implantable electronic devices: Insights into the host-bacteria dialog from blood and pocket tissue with pyrosequencing.
  • Masud F et al: Preventing healthcare-associated infections in cardiac surgical patients as a hallmark of excellence.
  • Popov AF et al: Treatment of gram-positive deep sternal wound infections in cardiac surgery--experiences with daptomycin.
  • Fechner H et al: Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707154027.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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10. Lind K, Svedin E, Utorova R, Stone VM, Flodström-Tullberg M: Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection. Clin Exp Immunol; 2014 Sep;177(3):687-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection.
  • Hepatitis is a common and potentially fatal manifestation of severe Coxsackievirus infections, particularly in newborn children.
  • Little is known of the immune-mediated mechanisms regulating permissiveness to liver infection.
  • It is well established that type I interferons (IFNs) play an important role in the host innate immune response to Coxsackievirus infections.
  • Recent studies have highlighted a role for another IFN family, the type III IFNs (also called IFN-λ), in anti-viral defence.
  • Whether type III IFNs are produced by hepatocytes during a Coxsackievirus infection remains unknown.
  • Moreover, whether or not type III IFNs protects hepatocytes from a Coxsackievirus infection has not been addressed.
  • In this study, we show that primary human hepatocytes respond to a Coxsackievirus B3 (CVB3) infection by up-regulating the expression of type III IFNs.
  • We also demonstrate that type III IFNs induce an anti-viral state in hepatocytes characterized by the up-regulated expression of IFN-stimulated genes, including IFN-stimulated gene (ISG15), 2'-5'-oligoadenylate synthetase 2 (OAS2), protein kinase regulated by dsRNA (PKR) and myxovirus resistance protein 1 (Mx1).
  • Our studies suggest that human hepatocytes express type III IFNs in response to a Coxsackievirus infection and highlight a novel role for type III IFNs in regulating hepatocyte permissiveness to this clinically relevant type of virus.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Line. Coxsackievirus Infections / metabolism. Enterovirus B, Human / physiology. Female. Humans. Male. Middle Aged

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  • [Copyright] © 2014 British Society for Immunology.
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  • (PMID = 24773058.001).
  • [ISSN] 1365-2249
  • [Journal-full-title] Clinical and experimental immunology
  • [ISO-abbreviation] Clin. Exp. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 82115-62-6 / Interferon-gamma
  • [Other-IDs] NLM/ PMC4137853 [Available on 09/01/15]
  • [Keywords] NOTNLM ; Coxsackievirus / anti-viral defence / enterovirus / hepatocytes / interferons
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11. Chen SP, Huang YC, Li WC, Chiu CH, Huang CG, Tsao KC, Lin TY: Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008: a children's hospital experience. J Microbiol Immunol Infect; 2010 Apr;43(2):99-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008: a children's hospital experience.
  • BACKGROUND/PURPOSE: Coxsackievirus A2 (Cox A2) was the predominant serotype in the enterovirus outbreak in Taiwan, 2008.
  • However, detailed clinical features of Cox A2 infection have not been reported.
  • METHODS: A total of 280 hospitalized patients (97 with culture-proven EV71 infection and 183 with culture-proven Cox A2 infection) in 2008 at the Chang Gung Children's Medical Center were enrolled in this study.
  • Patients with EV71 infection had a significantly longer hospitalization period (4.1 vs. 3.0 days, p< 0.001).
  • Fever, fever for more than 3 days with a temperature above 39 degrees C, lethargy, poor activity, poor appetite and a myoclonic jerk were significantly associated with EV71 infection.
  • Fever, or fever with a temperature above 39 degrees C, febrile seizure, elevated white cell counts, and elevated serum C-reactive protein concentrations were significantly associated with Cox A2 infection.
  • Most patients with EV71 infection presented with hand-foot-mouth disease (78.3%), while most Cox A2-infected patients presented with herpangina (83.6%).
  • All the patients with Cox A2 infection showed total recovery.
  • One patient with EV71 infection died from encephalitis with cardiopulmonary failure, and 6.2% of EV71-infected children had neurologic sequelae.
  • Compared with those infected by EV71, the children with Cox A2 infection mostly presented with herpangina, had fewer central nervous system complications, and had better overall outcome.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Coxsackievirus Infections / pathology. Disease Outbreaks. Enterovirus / isolation & purification. Enterovirus Infections / epidemiology. Enterovirus Infections / pathology
  • [MeSH-minor] Central Nervous System Diseases / epidemiology. Central Nervous System Diseases / virology. Child. Child, Preschool. Female. Hand, Foot and Mouth Disease / epidemiology. Hand, Foot and Mouth Disease / pathology. Hand, Foot and Mouth Disease / virology. Herpangina / epidemiology. Herpangina / pathology. Herpangina / virology. Hospitals. Humans. Infant. Length of Stay. Male. Seasons. Sex Factors. Taiwan / epidemiology

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  • [Copyright] Copyright 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20457425.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Huang WT, Lee PI, Chang LY, Kao CL, Huang LM, Lu CY, Chen JM, Lee CY: Epidemic pleurodynia caused by coxsackievirus B3 at a medical center in northern Taiwan. J Microbiol Immunol Infect; 2010 Dec;43(6):515-8
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  • [Title] Epidemic pleurodynia caused by coxsackievirus B3 at a medical center in northern Taiwan.
  • Patients with known heart diseases or pulmonary consolidations were excluded.
  • Coxsackievirus B3 (CB3) was isolated in 15 (60%) of the 25 throat swab specimens.
  • Six patients were observed with tonsillar exudates and one was confirmed to have a CB3 urinary tract infection.
  • The clinical features and radiological findings suggest that CB3-associated epidemic pleurodynia might be a disease of the pleura and occasionally spreads to nearby tissues, resulting in chest wall myositis, pulmonary infiltrates and myopericarditis.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Coxsackievirus Infections / epidemiology. Coxsackievirus Infections / physiopathology. Coxsackievirus Infections / radiography. Coxsackievirus Infections / virology. Female. Hospitals, University. Humans. Infant. Infant, Newborn. Male. Pharynx / virology. Pleurisy / epidemiology. Pleurisy / physiopathology. Pleurisy / radiography. Pleurisy / virology. Taiwan / epidemiology. Tonsillitis / epidemiology. Tonsillitis / physiopathology. Tonsillitis / virology. Urinary Tract Infections / epidemiology. Urinary Tract Infections / physiopathology. Urinary Tract Infections / virology

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  • [Copyright] Copyright © 2010 Taiwan Society of Microbiology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21195979.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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13. Sun Y, Wang X, Yuan S, Dang M, Li X, Zhang XC, Rao Z: An open conformation determined by a structural switch for 2A protease from coxsackievirus A16. Protein Cell; 2013 Oct;4(10):782-92
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  • [Title] An open conformation determined by a structural switch for 2A protease from coxsackievirus A16.
  • Coxsackievirus A16 belongs to the family Picornaviridae, and is a major agent of hand-foot-and-mouth disease that infects mostly children, and to date no vaccines or antiviral therapies are available.
  • Here we present the crystal structure of coxsackievirus A16 2A protease, which interestingly forms hexamers in crystal as well as in solution.
  • This structure shows an open conformation, with its active site accessible, ready for substrate binding and cleavage activity.
  • In addition, we compared the in vitro cleavage efficiency of 2A proteases from coxsackievirus A16 and enterovirus 71 upon the same substrates by fluorescence resonance energy transfer (FRET), and observed higher protease activity of enterovirus 71 compared to that of coxsackievirus A16.
  • In conclusion, our study shows an open conformation of coxsackievirus A16 2A protease and the underlying mechanisms for conformational conversion and substrate specificity.
  • [MeSH-major] Cysteine Endopeptidases / chemistry. Hand, Foot and Mouth Disease / enzymology. Picornaviridae / enzymology. Protein Conformation. Viral Proteins / chemistry
  • [MeSH-minor] Coxsackievirus Infections / virology. Crystallography, X-Ray. Fluorescence Resonance Energy Transfer. Humans. Structure-Activity Relationship. Substrate Specificity

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  • (PMID = 24026848.001).
  • [ISSN] 1674-8018
  • [Journal-full-title] Protein & cell
  • [ISO-abbreviation] Protein Cell
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Viral Proteins; EC 3.4.22.- / Cysteine Endopeptidases; EC 3.4.22.29 / picornain 2A, Picornavirus
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14. Xu GZ, Ni HX, Yi B, He TF, Dong HJ, Fang T, Gu WZ, Xie L: [Epidemiological and etiological characteristics of hand-foot-mouth disease in Ningbo, Zhejiang province, 2008-2011]. Zhonghua Liu Xing Bing Xue Za Zhi; 2013 Apr;34(4):361-5
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  • [Title] [Epidemiological and etiological characteristics of hand-foot-mouth disease in Ningbo, Zhejiang province, 2008-2011].
  • OBJECTIVE: To analyze the epidemiological characteristics of hand foot and mouth disease (HFMD) in Ningbo.
  • Cox A16 belonged to the B1 evolution branch, which were in line with the predominant virus circulating in the mainland of China.
  • [MeSH-major] Enterovirus / isolation & purification. Hand, Foot and Mouth Disease / epidemiology. Hand, Foot and Mouth Disease / virology
  • [MeSH-minor] Child. Child, Preschool. China / epidemiology. Coxsackievirus Infections / epidemiology. Female. Humans. Incidence. Infant. Infant, Newborn. Male

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  • (PMID = 23937841.001).
  • [ISSN] 0254-6450
  • [Journal-full-title] Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
  • [ISO-abbreviation] Zhonghua Liu Xing Bing Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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15. Zhu B, Zhong JY, Xia HM, Gong ST, Xiao MS, Xie JH, Zhang YY, Hua L, Lian GW: [Etiology of hand, foot and mouth disease in Guangzhou in 2008]. Zhonghua Er Ke Za Zhi; 2010 Feb;48(2):127-30
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  • [Title] [Etiology of hand, foot and mouth disease in Guangzhou in 2008].
  • OBJECTIVE: To understand the etiology of hand, foot and mouth disease (HFMD) in Guangzhou area in 2008.
  • TaqMan real-time RT-PCR were used for detection of enterovirus 71 (EV71), Coxsackievirus A16 (CA16) and other enteroviruses.
  • RESULT: Enterovirus was identified from 434 of 1023 samples and detection rate of enterovirus was 42.42%; of the 434 samples, 276 were positive for EV71 (63.6%), 126 for CA16 (29%), 4 samples for enterovirus 84, 3 for Echovirus 11, 2 for Echovirus 9, 3 for Coxsackievirus B3, 4 for Coxsackievirus A10, 3 for Coxsackievirus A6, 6 for Coxsackievirus A12 or A5, and for 7 samples typing was difficult.
  • [MeSH-major] Enterovirus A, Human / isolation & purification. Hand, Foot and Mouth Disease / virology
  • [MeSH-minor] Child. Child, Preschool. China / epidemiology. Coxsackievirus Infections / epidemiology. DNA Primers. Female. Humans. Infant. Male. RNA, Viral. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20426938.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi. Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA Primers; 0 / RNA, Viral
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16. Ryu WS, Kang B, Hong J, Hwang S, Kim J, Cheon DS: Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea. J Clin Microbiol; 2010 Jul;48(7):2490-4
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  • [Title] Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea.
  • Human enterovirus 71 (EV 71) has caused large-scale outbreaks of hand-foot-and-mouth disease (HFMD), particularly in the Asian-Pacific region.
  • In this study, we report a major outbreak of EV 71 infection in Korea and describe the clinical differences between EV 71 and non-EV 71 enterovirus infections.
  • We prospectively enrolled patients with suspected viral infections during a recent 2-year period through a nationwide surveillance system.
  • Patients with EV 71 infections tended to be younger than those with non-EV 71 enteroviral infections and presented with HFMD and meningoencephalitis.
  • In addition, the occurrence of fever, headache, and neck stiffness was significantly higher in patients with EV 71 infections.
  • Multivariable analysis showed that for patients presenting with HFMD, fever, or a sore throat, each covariate was independently associated with EV 71 infection; the adjusted odds ratios (with 95% confidence intervals in parentheses) for these variables were 31.86 (10.04 to 101.09), 4.76 (1.71 to 13.25), and 0.18 (0.04 to 0.77), respectively.
  • In addition, we found that clinical symptoms may be helpful in the early identification of patients with EV 71 infections.
  • [MeSH-major] Coxsackievirus Infections. Enterovirus A, Human / genetics
  • [MeSH-minor] Analysis of Variance. Child. Child, Preschool. Female. Genotype. Geography. Hand, Foot and Mouth Disease. Herpangina. Humans. Infant. Infant, Newborn. Male. Prevalence. Prospective Studies. Republic of Korea / epidemiology. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 20463159.001).
  • [ISSN] 1098-660X
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2897491
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17. Shi HJ, Liu JS, Wang LC, Zhang XM, Liu LD, Liao Y, Na RX, Li QH: [Biological characters of a coxsackievirus B3 variant strain isolated from a hand-foot-mouth disease patient with severe clinical symptoms]. Zhonghua Yi Xue Za Zhi; 2010 Apr 27;90(16):1141-4
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  • [Title] [Biological characters of a coxsackievirus B3 variant strain isolated from a hand-foot-mouth disease patient with severe clinical symptoms].
  • OBJECTIVE: To analyze the genetic and biological characters of a new isolate of coxsackievirus B3 (CoxB3), i.e.
  • FY-19 strain, and investigate its mechanistic role in causing different clinical symptoms of hand-foot-mouth disease (HFMD).
  • The viral replication kinetic analysis suggested that the FY-19 proliferation increased rapidly and peaked at 14 hours post-infection.
  • [MeSH-major] Enterovirus B, Human / classification. Enterovirus B, Human / genetics. Hand, Foot and Mouth Disease / virology
  • [MeSH-minor] Animals. Cell Line. Cercopithecus aethiops. Coxsackievirus Infections. Genotype. Humans. Mice. RNA, Viral. Vero Cells. Viral Proteins / genetics

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  • (PMID = 20646436.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / RNA, Viral; 0 / Viral Proteins
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18. Downing C, Ramirez-Fort MK, Doan HQ, Benoist F, Oberste MS, Khan F, Tyring SK: Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature. J Clin Virol; 2014 Aug;60(4):381-6
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  • [Title] Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature.
  • BACKGROUND: Hand, foot, and mouth disease (HFMD) is generally considered a rare illness in adults.
  • Classically, HFMD has been strongly associated with coxsackievirus strain A16 and enterovirus 71.
  • The coxsackievirus A6 (CVA6) strain has been linked to severe worldwide outbreaks since 2008.
  • CVA6 is associated with a more severe and profound course of disease, affecting both children and adults.
  • We investigate method of diagnosis and compare clinical presentation of adult cases to those in children.
  • Rapid plasma reagin (RPR) and serologic assays by complement fixation against coxsackievirus B (1-6) and A (2,4,7,9,10,16) were performed as indicated.
  • As standard serological testing does not detect CVA6, real-time reverse transcription-polymerase chain reaction (qRT-PCR) of serum, buccal swabs, and skin scrapings were performed by the Centers for Disease Control and Prevention (CDC).
  • CONCLUSION: This series demonstrates that there is a wide array of disease presentation of CVA6 associated HFMD in adults.
  • [MeSH-major] Coxsackievirus Infections / diagnosis. Enterovirus / classification. Hand, Foot and Mouth Disease / diagnosis. Hand, Foot and Mouth Disease / virology
  • [MeSH-minor] Adolescent. Adult. Complement Fixation Tests. Disease Outbreaks. Disease Progression. Female. Humans. Male. Reverse Transcriptase Polymerase Chain Reaction. Young Adult

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • [CommentIn] J Clin Virol. 2015 Jan;62:122 [25692203.001]
  • (PMID = 24932735.001).
  • [ISSN] 1873-5967
  • [Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • [ISO-abbreviation] J. Clin. Virol.
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article; Review
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Coxsackievirus A6 / Enterovirus / Hand foot and mouth disease
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19. Teng S, Zhao SY, Wei Y, Shao QM, Jiang MY, Cui DW, Xie GL: [Observation on virus shedding periods of enterovirus-71 and coxsackievirus A 16 monitored by nucleic acids determination in stool samples of children with hand, foot and mouth disease]. Zhonghua Er Ke Za Zhi; 2013 Oct;51(10):787-92
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  • [Title] [Observation on virus shedding periods of enterovirus-71 and coxsackievirus A 16 monitored by nucleic acids determination in stool samples of children with hand, foot and mouth disease].
  • OBJECTIVE: To observe the duration of enterovirus-71 (EV71) and coxsackievirus A 16 (CoxA16) viral shedding in stool samples of children with hand, foot and mouth disease (HFMD) infected with EV71 and CoxA16 and to explore the relationship between the duration of intestinal virus shedding and the severity of illness of children with HFMD.
  • The stool samples were collected with the interval of 4 to7 days and the viral nucleic acids were detected by fluorescent PCR until the stool viral nucleic acids of infected children turned to be negative.
  • The positive rates of viral nucleic acid and the differences of distribution among different groups were analyzed by Kaplan-Meier survival analysis during the follow-up period.
  • RESULT: The 113 cases of infected children were grouped as follows: 65 cases of EV71 positive children, 44 cases of CoxA16 positive children, 4 cases of EV71/CoxA16 mixed infection.
  • The median duration of the stool viral nucleic acids turning to negative was 26 (18.25-32.50) days in EV71 group and 27 (14.50-33.75) days in CoxA16 group (Z = 1.51, P > 0.05).
  • At 1, 4, 6 and 10 weeks, the positive rates of stool viral nucleic acid of children with HFMD in EV71 group were 100%, 48.1%, 17.2% and 0 respectively.
  • At 1, 4 and 6 weeks, the positive rates of stool viral nucleic acid of children with HFMD in CoxA16 group were 95.5%, 53.8% and 0 respectively (χ(2) = 0.18, P > 0.05).
  • At 1, 4 and 6 weeks, the positive rates of stool viral nucleic acid of children with HFMD in ordinary EV71 group were 100%, 23.5% and 0 respectively, while at 1, 4, 6 and 10 weeks, the positive rates of stool viral nucleic acid of children with HFMD in severe EV71 group were 100%, 62.4%, 26.0% and 0 respectively (χ(2) = 5.689, P < 0.05).
  • The duration of intestinal virus shedding of children with HFMD infected with EV71 was related with the severity of the illness.
  • [MeSH-major] Enterovirus A, Human / isolation & purification. Feces / virology. Hand, Foot and Mouth Disease / virology. Nucleic Acids / isolation & purification. Virus Shedding
  • [MeSH-minor] Child. Child, Preschool. China / epidemiology. Coxsackievirus Infections / diagnosis. Coxsackievirus Infections / epidemiology. Enterovirus / genetics. Enterovirus / isolation & purification. Female. Humans. Infant. Male. Polymerase Chain Reaction. RNA, Viral / genetics

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  • (PMID = 24406235.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi. Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Nucleic Acids; 0 / RNA, Viral
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20. Lo SH, Huang YC, Huang CG, Tsao KC, Li WC, Hsieh YC, Chiu CH, Lin TY: Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009. J Microbiol Immunol Infect; 2011 Aug;44(4):252-7
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  • [Title] Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009.
  • BACKGROUND: Isolates of Coxsackievirus A6 (Cox A6) is increasing clinically in 2009 in Taiwan but detailed clinical features of Cox A6 infections in children have not been reported.
  • This study is to define clinical manifestations and laboratory findings of Cox A6 infection in children.
  • METHODS: From January 2004 to December 2009, a total of 4,664 children with enterovirus infections, based on throat virus culture, were treated in Chang Gung Children's hospital.
  • Two hundred and ninety-six (6.3%) patients positive for Cox A6 infection were included in this study.
  • RESULTS: There were two peaks of Cox A6 infection in 2007 and 2009 during the study period, especially during the warm season.
  • One hundred and eight (76.6%) inpatients were diagnosed as herpangina and 18 (12.8%) hand-foot-mouth disease.
  • CONCLUSIONS: Cox A6 is among the major serotypes of enteroviruses in Taiwan and most cases presented as herpangina and hand-foot-mouth disease.
  • [MeSH-major] Coxsackievirus Infections / diagnosis. Coxsackievirus Infections / epidemiology. Enterovirus / isolation & purification

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  • [Copyright] Copyright © 2011. Published by Elsevier B.V.
  • (PMID = 21524960.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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21. Cai Y, Ku Z, Liu Q, Leng Q, Huang Z: A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses. Vaccine; 2014 May 1;32(21):2406-12
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  • [Title] A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses.
  • Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand, foot and mouth disease (HFMD), which is an infectious disease frequently occurring in children.
  • The two monovalent vaccines were found to elicit serum antibodies that potently neutralized the homologous virus but had no or weak neutralization activity against the heterologous one; in contrast, the bivalent vaccine immunized sera efficiently neutralized both EV71 and CA16.
  • More importantly, passive immunization with the bivalent vaccine protected mice against either EV71 or CA16 lethal infections, whereas the monovalent vaccines only prevented the homologous but not the heterologous challenges.
  • [MeSH-major] Coxsackievirus Infections / prevention & control. Enterovirus. Enterovirus A, Human. Viral Vaccines / immunology
  • [MeSH-minor] Animals. Antibodies, Neutralizing / blood. Antibodies, Viral / blood. Cercopithecus aethiops. Female. Hand, Foot and Mouth Disease / prevention & control. Immunization, Passive. Mice. Mice, Inbred ICR. Pregnancy. Pregnancy Complications, Infectious / prevention & control. Vaccines, Combined / immunology. Vero Cells

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  • [Copyright] Copyright © 2014 Elsevier Ltd. All rights reserved.
  • (PMID = 24657161.001).
  • [ISSN] 1873-2518
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Neutralizing; 0 / Antibodies, Viral; 0 / Vaccines, Combined; 0 / Viral Vaccines
  • [Keywords] NOTNLM ; Bivalent vaccine / Coxsackievirus A16 / Enterovirus 71 / Neutralizing antibody / Passive protection
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22. Tao Z, Song Y, Li Y, Liu Y, Jiang P, Lin X, Liu G, Song L, Wang H, Xu A: Coxsackievirus B3, Shandong Province, China, 1990-2010. Emerg Infect Dis; 2012 Nov;18(11):1865-7
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  • [Title] Coxsackievirus B3, Shandong Province, China, 1990-2010.
  • To determine the cause of a 2008 outbreak of aseptic meningitis in Shandong Province, China, we analyzed samples from outbreak patients and coxsackievirus B3 samples collected during 1990-2010 surveillance.
  • The cause of the outbreak was coxsackievirus B3, genogroup D.
  • Frequent travel might increase importation of other coxsackievirus B3 genogroups.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Enterovirus B, Human / classification
  • [MeSH-minor] Adolescent. Adult. Capsid Proteins / genetics. Child. Child, Preschool. China / epidemiology. Disease Outbreaks. Female. Humans. Infant. Male. Middle Aged. Molecular Sequence Data. Paralysis / epidemiology. Paralysis / virology. Phylogeny. Population Surveillance. Young Adult

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  • [Cites] J Clin Microbiol. 1999 Dec;37(12):3928-33 [10565909.001]
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  • (PMID = 23092737.001).
  • [ISSN] 1080-6059
  • [Journal-full-title] Emerging infectious diseases
  • [ISO-abbreviation] Emerging Infect. Dis.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ919564/ FJ919566/ FJ919567/ FJ919568/ FJ919569/ FJ919570/ FJ919571/ FJ919572/ FJ919573/ FJ919574/ FJ919575/ FJ919576/ FJ919577/ FJ919578/ FJ919579/ FJ919580/ FJ919581/ FJ919582/ FJ919583/ FJ919584/ FJ919585/ FJ919586/ FJ919587/ FJ919588/ FJ919589/ FJ919590/ FJ919591/ FJ919592/ FJ919593/ FJ919594/ FJ919595/ FJ919596/ FJ919597/ FJ919598/ GQ246518/ GQ329744/ GQ329745/ GQ329746/ GQ329747/ GQ329748/ GQ329749/ GQ329750/ GQ329751/ GQ329752/ GQ329753/ GQ329754/ GQ329755/ GQ329756/ GQ329757/ GQ329758/ GQ329759/ GQ329760/ GQ329761/ GQ329762/ GQ329763/ GQ329764/ GQ329765/ GQ329766/ GQ329767/ GU272011/ GU272012/ GU272013/ JQ364844/ JQ364845/ JQ364846/ JQ364847/ JQ364848/ JQ364849/ JQ364850/ JQ364851/ JQ364852/ JQ364853/ JQ364854/ JQ364855/ JQ364856/ JQ364857/ JQ364858/ JQ364859/ JQ364860/ JQ364861/ JQ364862/ JQ364863/ JQ364864/ JQ364865/ JQ364866/ JQ364867/ JQ364868/ JQ364869/ JQ364870/ JQ364871/ JQ364872/ JQ364873/ JQ364874/ JQ364875/ JQ364876/ JQ364877/ JQ364878/ JQ364879/ JQ364880/ JQ364881/ JQ364882/ JQ364883/ JQ364884/ JQ364885
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Capsid Proteins
  • [Other-IDs] NLM/ PMC3559141
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23. Tao Z, Li B, Xu A, Liu Y, Song L, Wang S, Xiong P, Lin X, Song Y: Seroprevalence of coxsackievirus B3 in Yantai, China. Jpn J Infect Dis; 2013;66(6):537-8
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  • [Title] Seroprevalence of coxsackievirus B3 in Yantai, China.
  • Coxsackievirus B3 (CVB3) is an important human pathogen, which is frequently associated with aseptic meningitis and encephalitis in many parts of the world.
  • However, the seroprevalence of this viral infection in China is not well understood; therefore, in the present study, we conducted a serological survey in which 373 serum samples obtained from healthy people belonging to 10 age groups in Yantai city, China were examined.
  • Our results indicated that CVB3 infections occurred mostly in preschool and early-elementary school settings, and children <5 years of age are the most susceptible populations due to their low CVB3 antibody levels.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Enterovirus B, Human / isolation & purification
  • [MeSH-minor] Adolescent. Antibodies, Neutralizing / blood. Antibodies, Viral / blood. Child. Child, Preschool. China / epidemiology. Female. Humans. Infant. Male. Seroepidemiologic Studies

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  • (PMID = 24270146.001).
  • [ISSN] 1884-2836
  • [Journal-full-title] Japanese journal of infectious diseases
  • [ISO-abbreviation] Jpn. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Neutralizing; 0 / Antibodies, Viral
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24. Chu PY, Ke GM, Chen YS, Lu PL, Chen HL, Lee MS, Chen BC, Huang TS, Li YC, Chou LC, Wang SY, Lin KH: Molecular epidemiology of Coxsackievirus B3. Infect Genet Evol; 2010 Aug;10(6):777-84
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  • [Title] Molecular epidemiology of Coxsackievirus B3.
  • Molecular epidemiological characteristics are needed to understand the impact of Coxsackievirus B3 (CV-B3) infection, since no CV-B3 genotyping literature is available.
  • Half of them contracted respiratory tract infection (12/24).
  • CNS infections were not associated with a specific strain or genotype.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Coxsackievirus Infections / virology. Enterovirus B, Human / genetics
  • [MeSH-minor] Americas / epidemiology. Amino Acid Sequence. Amino Acid Substitution. Child. Child, Preschool. Disease Outbreaks. Europe / epidemiology. Female. Genotype. Humans. Infant. Infant, Newborn. Male. Molecular Epidemiology. Molecular Sequence Data. Phylogeny. Sequence Homology, Amino Acid. Taiwan / epidemiology

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20398802.001).
  • [ISSN] 1567-7257
  • [Journal-full-title] Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • [ISO-abbreviation] Infect. Genet. Evol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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25. Saikia UN, Mishra B, Sharma M, Nada R, Radotra B: Disseminated coxsackievirus B fulminant myocarditis in an immunocompetent adult: a case report: case of disseminated coxsackievirus myocarditis. Diagn Microbiol Infect Dis; 2014 Jan;78(1):98-100
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  • [Title] Disseminated coxsackievirus B fulminant myocarditis in an immunocompetent adult: a case report: case of disseminated coxsackievirus myocarditis.
  • We report a case of fulminant myocarditis along with dissemination of coxsackievirus, which was clinically unrecognized.
  • [MeSH-major] Coxsackievirus Infections / diagnosis. Coxsackievirus Infections / pathology. Enterovirus B, Human / isolation & purification. Myocarditis / diagnosis. Myocarditis / pathology

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  • [Copyright] © 2013.
  • (PMID = 24182898.001).
  • [ISSN] 1879-0070
  • [Journal-full-title] Diagnostic microbiology and infectious disease
  • [ISO-abbreviation] Diagn. Microbiol. Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Coxsackievirus / Dissemination / Fulminant / Myocarditis
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26. Inal JM, Jorfi S: Coxsackievirus B transmission and possible new roles for extracellular vesicles. Biochem Soc Trans; 2013 Feb 1;41(1):299-302
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coxsackievirus B transmission and possible new roles for extracellular vesicles.
  • Coxsackievirus B1, a member of the Picornaviridae family is a non-enveloped single-stranded RNA virus associated with human diseases including myocarditis and pancreatitis.
  • Infection of the intestinal mucosa, lined by polarized epithelial cells, requires interaction of coxsackievirus with apically located DAF (decay-accelerating factor) before transport to the basolaterally located CAR (coxsackie and adenovirus receptor), where entry is mediated by endocytosis.
  • As with many other non-enveloped viruses, coxsackievirus has to induce lysis of host cells in order to perpetuate infection.
  • However, recent evidence indicates that virus spread to secondary sites is not only achieved by a lytic mechanism and a non-lytic cell-cell strategy has been suggested for coxsackievirus B3.
  • Calpain-mediated depolymerization of the actin cytoskeleton, as a result of increases in intracellular calcium concentration during coxsackievirus infection, would result in a release of host cell-derived microvesicles.
  • [MeSH-major] Coxsackievirus Infections / transmission. Enterovirus B, Human / isolation & purification

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  • (PMID = 23356301.001).
  • [ISSN] 1470-8752
  • [Journal-full-title] Biochemical Society transactions
  • [ISO-abbreviation] Biochem. Soc. Trans.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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27. Fairweather D, Stafford KA, Sung YK: Update on coxsackievirus B3 myocarditis. Curr Opin Rheumatol; 2012 Jul;24(4):401-7
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  • [Title] Update on coxsackievirus B3 myocarditis.
  • PURPOSE OF REVIEW: To present recent findings on the pathogenesis of coxsackievirus B3 (CVB3) myocarditis based on animal models, with a focus on the role of T helper (Th) immune responses in disease progression.
  • RECENT FINDINGS: Acute CVB3 myocarditis is known to be increased by Th1 immune responses, but recent findings indicate that Th1-type immunity protects against acute myocarditis by reducing viral replication and prevents the progression to chronic myocarditis and dilated cardiomyopathy (DCM) by inhibiting Th2 responses.
  • Th1 responses protect against CVB3 myocarditis by inhibiting Th2 responses and viral replication, but increase acute inflammation.
  • [MeSH-major] Autoimmune Diseases / virology. Coxsackievirus Infections / complications. Enterovirus B, Human. Myocarditis / virology
  • [MeSH-minor] Animals. Disease Models, Animal. Mice. T-Lymphocytes, Helper-Inducer / immunology

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  • (PMID = 22488075.001).
  • [ISSN] 1531-6963
  • [Journal-full-title] Current opinion in rheumatology
  • [ISO-abbreviation] Curr Opin Rheumatol
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL087033; United States / NIEHS NIH HHS / ES / T32 ES007141
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
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28. Rassmann A, Martin U, Saluz HP, Peter S, Munder T, Henke A: Identification of gene expression profiles in HeLa cells and HepG2 cells infected with Coxsackievirus B3. J Virol Methods; 2013 Jan;187(1):190-4
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  • [Title] Identification of gene expression profiles in HeLa cells and HepG2 cells infected with Coxsackievirus B3.
  • Viral infections of host cells cause multiple changes of cellular metabolism including immediate defense mechanisms as well as processes to support viral replication.
  • Coxsackievirus B3 (CVB3) is a member of the Picornavirus family and is responsible for a wide variety of mild or severe infections including acute and chronic inflammations.
  • Expression analysis of HeLa cells and HepG2 cells infected with CVB3 identified 34 genes whose mRNA levels were altered significantly upon infection.
  • All genes expressed differentially were sorted with regard to their functions and interpreted in view of known contributors to the infection process.
  • [MeSH-major] Coxsackievirus Infections / genetics. Coxsackievirus Infections / metabolism. Enterovirus B, Human / genetics. RNA, Messenger / biosynthesis
  • [MeSH-minor] Apoptosis / genetics. Cell Line, Tumor. Enzyme Activation. Gene Expression. Gene Expression Profiling. HeLa Cells / virology. Hep G2 Cells / virology. Humans. Oligonucleotide Array Sequence Analysis. Signal Transduction / genetics. Tumor Necrosis Factor-alpha / genetics. Tumor Necrosis Factor-alpha / metabolism. Virus Replication / genetics

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
  • (PMID = 23000448.001).
  • [ISSN] 1879-0984
  • [Journal-full-title] Journal of virological methods
  • [ISO-abbreviation] J. Virol. Methods
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha
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29. Roberts BJ, Moussawi M, Huber SA: Sex differences in TLR2 and TLR4 expression and their effect on coxsackievirus-induced autoimmune myocarditis. Exp Mol Pathol; 2013 Feb;94(1):58-64
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  • [Title] Sex differences in TLR2 and TLR4 expression and their effect on coxsackievirus-induced autoimmune myocarditis.
  • Coxsackievirus B3 (CVB3) infection of C57Bl/6 mice shows a sex bias with males developing more severe cardiac inflammation than females because males develop a Th1 inflammatory response, whereas females develop a Th2 response.
  • To assess the role of TLRs in coxsackievirus-induced myocarditis wild type and Toll-like receptor 2-/- male and female mice were infected and assessed for viral replication, myocarditis, helper T-cell generation, and regulatory T-cell generation.
  • [MeSH-major] Coxsackievirus Infections / immunology. Myocarditis / immunology. Myocarditis / virology. Sex Characteristics. Toll-Like Receptor 2 / metabolism. Toll-Like Receptor 4 / metabolism
  • [MeSH-minor] Animals. Autoimmune Diseases / immunology. Autoimmune Diseases / metabolism. Disease Susceptibility / immunology. Enterovirus / immunology. Female. Lipopeptides / pharmacology. Lipopolysaccharides / pharmacology. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Nerve Tissue Proteins / biosynthesis. Nuclear Proteins / biosynthesis. T-Lymphocytes, Regulatory / immunology. T-Lymphocytes, Regulatory / metabolism. Th1 Cells / metabolism

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
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  • (PMID = 22750431.001).
  • [ISSN] 1096-0945
  • [Journal-full-title] Experimental and molecular pathology
  • [ISO-abbreviation] Exp. Mol. Pathol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL108371; United States / NIAID NIH HHS / AI / P01 AI045666; United States / NIGMS NIH HHS / GM / P20 GM103496; United States / NCRR NIH HHS / RR / P20 RR021905; United States / NHLBI NIH HHS / HL / R01 HL108371; United States / NCRR NIH HHS / RR / T20-RR021905
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopeptides; 0 / Lipopolysaccharides; 0 / Nerve Tissue Proteins; 0 / NeuN protein, mouse; 0 / Nuclear Proteins; 0 / Pam(3)CSK(4) peptide; 0 / Tlr2 protein, mouse; 0 / Tlr4 protein, mouse; 0 / Toll-Like Receptor 2; 0 / Toll-Like Receptor 4
  • [Other-IDs] NLM/ NIHMS390723; NLM/ PMC3485413
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30. Kaçar N, Cevahir N, Demirkan N, Şanlı B: The investigation of the possible relationship between Coxsackie viruses and pemphigus. Int J Dermatol; 2014 Mar;53(3):312-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The investigation of the possible relationship between Coxsackie viruses and pemphigus.
  • BACKGROUND: Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed.
  • Coxsackie viruses (CVs) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases.
  • The onset of pemphigus after CV infection and cephalosporin use has been reported.
  • CONCLUSION: Our preliminary results indicate that the viral genome of CV does not become persistent in the skin.
  • [MeSH-major] Coxsackievirus Infections / complications. Coxsackievirus Infections / immunology. Pemphigus / immunology. Pemphigus / virology. Skin / virology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Antibodies, Viral / metabolism. Biopsy. Coxsackie and Adenovirus Receptor-Like Membrane Protein / genetics. Coxsackie and Adenovirus Receptor-Like Membrane Protein / metabolism. Enzyme-Linked Immunosorbent Assay. Female. Humans. Immunoglobulin G / metabolism. Immunoglobulin M / metabolism. Male. Middle Aged. Polymerase Chain Reaction. RNA, Viral / metabolism

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  • [Copyright] © 2013 The International Society of Dermatology.
  • (PMID = 23879594.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Coxsackie and Adenovirus Receptor-Like Membrane Protein; 0 / Immunoglobulin G; 0 / Immunoglobulin M; 0 / RNA, Viral
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31. Akuzawa N, Harada N, Hatori T, Imai K, Kitahara Y, Sakurai S, Kurabayashi M: Myocarditis, hepatitis, and pancreatitis in a patient with coxsackievirus A4 infection: a case report. Virol J; 2014;11:3
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  • [Title] Myocarditis, hepatitis, and pancreatitis in a patient with coxsackievirus A4 infection: a case report.
  • Viral myocarditis presents with various symptoms, including fatal arrhythmia and cardiogenic shock, and may develop chronic myocarditis and dilated cardiomyopathy in some patients.
  • We report here a case of viral myocarditis with liver dysfunction and pancreatitis.
  • Further investigation revealed a high antibody titer against coxsackievirus A4.
  • He has now been followed-up for two years, and his left ventricular ejection fraction is stable.This is the first report of an adult with myocarditis and pancreatitis attributed to coxsackievirus A4.
  • Combined myocarditis and pancreatitis arising from coxsackievirus infection is rare.
  • This patient's clinical course suggests that changes in his immune response associated with his rectal cancer contributed to the amelioration of his viral myocarditis.
  • [MeSH-major] Coxsackievirus Infections / diagnosis. Coxsackievirus Infections / pathology. Enterovirus / isolation & purification. Hepatitis, Viral, Human / etiology. Myocarditis / etiology. Pancreatitis / etiology
  • [MeSH-minor] Humans. Immunocompromised Host. Male. Middle Aged. Rectal Neoplasms / complications. Rectal Neoplasms / diagnosis


32. Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R: The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathog; 2014 Jul;10(7):e1004249
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  • [Title] The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development.
  • Coxsackievirus B (CVB) is an enterovirus that most commonly causes a self-limited febrile illness in infants, but cases of severe infection can manifest in acute myocarditis.
  • Chronic consequences of mild CVB infection are unknown, though there is an epidemiologic association between early subclinical infections and late heart failure, raising the possibility of subtle damage leading to late-onset dysfunction, or chronic ongoing injury due to inflammatory reactions during latent infection.
  • Here we describe a mouse model of juvenile infection with a subclinical dose of coxsackievirus B3 (CVB3) which showed no evident symptoms, either immediately following infection or in adult mice.
  • These results suggest that the exhausted cardiac progenitor cell pool following juvenile CVB3 infection may impair the heart's ability to increase capillary density to adapt to increased load.
  • [MeSH-major] Coxsackievirus Infections / pathology. Enterovirus B, Human / pathogenicity. Fibrosis / pathology. Heart / growth & development. Myocytes, Cardiac / cytology. Stem Cells / cytology
  • [MeSH-minor] Animals. Cell Differentiation. Disease Models, Animal. Female. Heart Failure / chemically induced. Heart Failure / pathology. Heart Failure / virology. Male. Mice. Mice, Inbred BALB C. Stress, Physiological

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  • (PMID = 25079373.001).
  • [ISSN] 1553-7374
  • [Journal-full-title] PLoS pathogens
  • [ISO-abbreviation] PLoS Pathog.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL092136; United States / NIMH NIH HHS / MH / MH065515; United States / NINDS NIH HHS / NS / NS054108; United States / NHLBI NIH HHS / HL / P01 HL085577; United States / NHLBI NIH HHS / HL / R01 HL067245; United States / NHLBI NIH HHS / HL / R01 HL105759; United States / NHLBI NIH HHS / HL / R01 HL113647; United States / NHLBI NIH HHS / HL / R01 HL117163; United States / NHLBI NIH HHS / HL / R01 HL122525; United States / NHLBI NIH HHS / HL / R37 HL091102; United States / NHLBI NIH HHS / HL / T32 HL116273
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4117602
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33. Wang L, Dong C, Chen DE, Song Z: Coxsackievirus-induced acute neonatal central nervous system disease model. Int J Clin Exp Pathol; 2014;7(3):858-69
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coxsackievirus-induced acute neonatal central nervous system disease model.
  • Coxsackievirus B (CVB) is a significant pathogen that causes pediatric central nervous system disease with acute syndromes commonly.
  • The onset of its infection was abrupt, and after recovery there usually will be severe mental sequelae.
  • The disease model for research was not established by the way of natural infection, although there are various investigations about the CVB-induced central nervous system (CNS) diseases.
  • Thus, we have established an acute neonatal CNS disease mice model by CVB orally infecting.
  • This model imitated the natural infection route and focuses the onset of CNS disease, inducing severe infection and lesion in the hippocampus and cortex regions, and the stability of the model was demonstrated.
  • The model is an effective tool for studies on CVB-induced CNS diseases.
  • [MeSH-major] Central Nervous System Diseases / virology. Coxsackievirus Infections / pathology. Disease Models, Animal. Enterovirus / genetics
  • [MeSH-minor] Animals. Animals, Newborn. Brain / pathology. Brain / virology. DNA, Viral / genetics. DNA, Viral / isolation & purification. Female. Immunohistochemistry. Male. Mice. Mice, Inbred BALB C

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  • (PMID = 24696707.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  • [Other-IDs] NLM/ PMC3971288
  • [Keywords] NOTNLM ; Coxsackievirus B / acute neonatal central nervous system disease / mouse model / strain Macocy
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34. Kim DS, Nam JH: Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines. Expert Opin Biol Ther; 2010 Feb;10(2):179-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Characterization of attenuated coxsackievirus B3 strains and prospects of their application as live-attenuated vaccines.
  • Coxsackievirus strain CVB3 is widespread in the human population and causes myocarditis or pancreatitis.
  • [MeSH-minor] Animals. Antibodies, Viral / biosynthesis. Coxsackievirus Infections / immunology. Coxsackievirus Infections / prevention & control. Coxsackievirus Infections / virology. Genetic Vectors. Humans. Mutation / genetics. Receptors, Virus / genetics

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  • (PMID = 20088713.001).
  • [ISSN] 1744-7682
  • [Journal-full-title] Expert opinion on biological therapy
  • [ISO-abbreviation] Expert Opin Biol Ther
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Viral; 0 / Receptors, Virus; 0 / Vaccines, Attenuated; 0 / coxsackievirus B receptor
  • [Number-of-references] 96
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35. Tabor-Godwin JM, Tsueng G, Sayen MR, Gottlieb RA, Feuer R: The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy; 2012 Jun;8(6):938-53
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  • [Title] The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.
  • Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell.
  • However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells.
  • Therefore, we compared the induction of autophagy following CVB3 infection of neural progenitor and stem cells (NPSCs), which we have recently shown to be highly susceptible to CVB3 infection, to HL-1 cells, a transformed cardiomyocyte cell line.
  • As previously demonstrated for other susceptible host cells, HL-1 cells showed an increase in the activity of autophagic signaling following infection with a CVB3 expressing dsRed protein (dsRed-CVB3).
  • Furthermore, viral titers in HL-1 cells increased in the presence of an inducer of autophagy (CCPA), while viral titers decreased in the presence of an inhibitor of autophagy (3-MA).
  • In contrast, no change in autophagic signaling was seen in NPSCs following infection with dsRed-CVB3.
  • In differentiated NPSC precursors, autophagy was activated during the differentiation process, and a decrease in autophagic signaling was observed within all three CNS lineages following dsRed-CVB3 infection.
  • Hence, we conclude that the role of autophagy in modulating CVB3 replication appears cell type-specific, and stem cells may uniquely regulate autophagy in response to infection.
  • [MeSH-major] Autophagy. Coxsackievirus Infections / pathology. Neural Stem Cells / pathology. Neural Stem Cells / virology
  • [MeSH-minor] Adenine / analogs & derivatives. Adenine / pharmacology. Adenosine / analogs & derivatives. Adenosine / pharmacology. Animals. Cell Differentiation / drug effects. Enterovirus B, Human / drug effects. Enterovirus B, Human / physiology. Fibroblast Growth Factors / pharmacology. Green Fluorescent Proteins / metabolism. HeLa Cells. Humans. Mice. Mice, Inbred C57BL. Microtubule-Associated Proteins / metabolism. Proto-Oncogene Proteins c-bcl-2 / metabolism. Signal Transduction / drug effects. Sirolimus / pharmacology. Transduction, Genetic. Viral Load / drug effects. Viral Proteins / metabolism. Virus Replication / drug effects

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  • (PMID = 22751470.001).
  • [ISSN] 1554-8635
  • [Journal-full-title] Autophagy
  • [ISO-abbreviation] Autophagy
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / 3R01NS054108-01A2S1; United States / NHLBI NIH HHS / HL / R01 HL092136; United States / NHLBI NIH HHS / HL / R01 HL092136; United States / NINDS NIH HHS / NS / R01 NS054108; United States / NIMH NIH HHS / MH / R24 MH065515
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Microtubule-Associated Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Viral Proteins; 147336-22-9 / Green Fluorescent Proteins; 37739-05-2 / 2-chloro-N(6)cyclopentyladenosine; 5142-23-4 / 3-methyladenine; 62031-54-3 / Fibroblast Growth Factors; JAC85A2161 / Adenine; K72T3FS567 / Adenosine; W36ZG6FT64 / Sirolimus
  • [Other-IDs] NLM/ PMC3427259
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36. Wu YD, Shang SQ, Chen ZM, Yang ZH: [Analysis of the epidemic characteristics of the etiological agents in children with hand, foot and mouth disease and its clinical significance]. Zhonghua Er Ke Za Zhi; 2010 Jul;48(7):535-9
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  • [Title] [Analysis of the epidemic characteristics of the etiological agents in children with hand, foot and mouth disease and its clinical significance].
  • OBJECTIVE: To investigate the epidemic characteristics of etiological agents in children with hand, foot and mouth disease (HFMD) and analyze the differences between the severe and mild cases with HFMD seen from 2008 to 2009 in the Children's Hospital.
  • Enterovirus universal type, enterovirus type 71 (EV71) and coxsackie virus group A 16 (CA16) were detected by real-time RT-PCR respectively.
  • EV71 positive rate in these 126 patients with enterovirus universal type infection was 57.14%(72/126).
  • There was no EV71 infection in these 80 cases with suspected herpangina.
  • EV71 infection was mainly popular in 2008.
  • The epidemic characteristics of enterovirus infection with HFMD between 2008 and 2009 had significant differences (χ(2) = 23.50, P = 0.000) (P < 0.01).
  • The epidemic characteristics of enterovirus infection between severe and mild HFMD patients also had significant differences (χ(2) = 29.85, P < 0.01).
  • There was no significant difference in the gender (χ(2) = 0.135, P = 0.714) and virus load (t = 0.141, P = 0.889) between the mild and severe HFMD cases.
  • CONCLUSION: HFMD showed different epidemic characteristics at different times of enterovirus infection.
  • There was no significant difference in the gender and virus load between the mild and severe cases with HFMD.
  • Children under 3 years of age with EV71 infection were at high risk for severe HFMD.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Hand, Foot and Mouth Disease / epidemiology. Hand, Foot and Mouth Disease / virology
  • [MeSH-minor] Child. Child, Preschool. China / epidemiology. Enterovirus. Female. Humans. Infant. Male. Viral Load

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  • (PMID = 21055092.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi. Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] Controlled Clinical Trial; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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37. Liu Q, Shi J, Huang X, Liu F, Cai Y, Lan K, Huang Z: A murine model of coxsackievirus A16 infection for anti-viral evaluation. Antiviral Res; 2014 May;105:26-31
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  • [Title] A murine model of coxsackievirus A16 infection for anti-viral evaluation.
  • Coxsackievirus A16 (CA16) is one of the main causative agents of hand, foot and mouth disease (HFMD), which is a common infectious disease in children.
  • CA16 infection may lead to severe nervous system damage and even death in humans.
  • However, study of the pathogenesis of CA16 infection and development of vaccines and anti-viral agents are hindered partly by the lack of an appropriate small animal model.
  • In the present study, we developed and characterized a murine model of CA16 infection.
  • We show that neonatal mice are susceptible to CA16 infection via intraperitoneal inoculation.
  • About 57% of the mice died within 14days after infection.
  • Significant damage in the brainstem, limb muscles and intestines of the infected mice in the moribund state was observed by histological examination, and the presence of CA16 in neurons of the brainstem was demonstrated by immunohistochemical staining with a CA16-specific polyclonal antibody, strongly suggesting the involvement of the central nervous system in CA16 infection.
  • Analysis of virus titers in various organs/tissues collected at 3, 6 and 9days post-infection, showed that skeletal muscle was the major site of virus replication at the early stage of infection, while the virus mainly accumulated in the brain at the late stage.
  • In addition, susceptibility of mice to CA16 infection was found to be age dependent.
  • Importantly, we demonstrated that post-exposure treatment with an anti-CA16 monoclonal antibody fully protected mice against lethal CA16 infection.
  • Collectively, these results indicate the successful development of a CA16 infection mouse model for anti-viral evaluation.
  • [MeSH-major] Coxsackievirus Infections / pathology. Disease Models, Animal. Enterovirus / isolation & purification
  • [MeSH-minor] Animal Structures / pathology. Animal Structures / virology. Animals. Animals, Newborn. Antiviral Agents / isolation & purification. Antiviral Agents / therapeutic use. Drug Evaluation, Preclinical / methods. Histocytochemistry. Immunohistochemistry. Mice, Inbred ICR. Survival Analysis. Viral Load

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 24583030.001).
  • [ISSN] 1872-9096
  • [Journal-full-title] Antiviral research
  • [ISO-abbreviation] Antiviral Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antiviral Agents
  • [Keywords] NOTNLM ; Coxsackievirus A16 / Infection / Monoclonal antibody / Murine model
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38. Lott JP, Liu K, Landry ML, Nix WA, Oberste MS, Bolognia J, King B: Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J Am Acad Dermatol; 2013 Nov;69(5):736-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection.
  • BACKGROUND: Hand-foot-and-mouth disease (HFMD) is an acute viral illness commonly caused by coxsackievirus (CV)-A16 and enterovirus 71 infections.
  • OBJECTIVE: We sought to describe the clinical features of atypical HFMD associated with CV-A6 infection and its diagnostic laboratory evaluation.
  • Enterovirus infection was assessed by reverse transcriptase polymerase chain reaction of biologic specimens.
  • Enterovirus type was determined by viral capsid protein 1 gene sequencing.
  • Infection with CV-A6 was confirmed in all patients.
  • CONCLUSION: Consideration of the expanded range of cutaneous findings in atypical HFMD caused by CV-A6 infection may assist clinicians in diagnosis and management.
  • [MeSH-major] Coxsackievirus Infections / complications. Enterovirus A, Human. Hand, Foot and Mouth Disease / complications. Hand, Foot and Mouth Disease / virology

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 24035209.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; AD / CDC / CV / Centers for Disease Control and Prevention / ED / HFMD / PCR / RT / atopic dermatitis / atypical / coxsackievirus / coxsackievirus A6 / diagnosis / emergency department / enterovirus / evaluation / exanthem / hand-foot-and-mouth disease / polymerase chain reaction / reverse transcriptase
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39. Yi L, Lu J, Kung HF, He ML: The virology and developments toward control of human enterovirus 71. Crit Rev Microbiol; 2011 Nov;37(4):313-27
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  • Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, was first recognized as a dermotrophic virus that usually cause mild, self-limiting hand-foot-and-mouth disease (HFMD).
  • However, EV71 infection can sometimes induce a variety of severe neurological complications and even death.
  • Current large outbreaks of EV71 make this virus being a major public health issue.
  • Intense effort has been made to address its underlying pathogenesis and to develop effective means for combating EV71 infections.
  • Here, we aimed to provide an overview of cellular mechanisms underlying EV71 infection and to assess potential agents for prevention and treatment of EV71 infections.
  • [MeSH-major] Coxsackievirus Infections / prevention & control. Enterovirus A, Human
  • [MeSH-minor] Disease Outbreaks / prevention & control. Humans

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  • (PMID = 21651436.001).
  • [ISSN] 1549-7828
  • [Journal-full-title] Critical reviews in microbiology
  • [ISO-abbreviation] Crit. Rev. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
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40. Stewart CL, Chu EY, Introcaso CE, Schaffer A, James WD: Coxsackievirus A6-induced hand-foot-mouth disease. JAMA Dermatol; 2013 Dec;149(12):1419-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Coxsackievirus A6-induced hand-foot-mouth disease.
  • IMPORTANCE: Hand-foot-mouth disease (HFMD) is an acute, self-limited, highly contagious viral illness that commonly affects children younger than 5 years.
  • It is most typically caused by enterovirus 71 or coxsackievirus A16 and results in asymptomatic infection or mild disease.
  • Recently, there have been increasing reports of a more severe form of HFMD associated with fevers, joint pains, and widespread painful eruptions.
  • These severe cases were most commonly caused by coxsackievirus A6.
  • His infection with coxsackievirus A6 was confirmed based on polymerase chain reaction from his oral mucosa and cutaneous vesicle fluid.
  • CONCLUSIONS AND RELEVANCE: Dermatologists should be familiar with the severe variant of HFMD caused by coxsackievirus A6, include it in their differential diagnosis of acute febrile blistering diseases, and be aware that certain patients may require hospitalization.
  • [MeSH-major] Coxsackievirus Infections / physiopathology. Enterovirus A, Human / isolation & purification. Hand, Foot and Mouth Disease / physiopathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Hospitalization. Humans. Male. Polymerase Chain Reaction. Severity of Illness Index

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  • (PMID = 24172861.001).
  • [ISSN] 2168-6084
  • [Journal-full-title] JAMA dermatology
  • [ISO-abbreviation] JAMA Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Ku Z, Liu Q, Ye X, Cai Y, Wang X, Shi J, Li D, Jin X, An W, Huang Z: A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice. Vaccine; 2014 Jul 23;32(34):4296-303
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  • [Title] A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice.
  • Enterovirus 71(EV71) and coxsackievirus A16 (CA16) are responsible for hand, foot and mouth disease which has been prevalent in Asia-Pacific regions, causing significant morbidity and mortality in young children.
  • Co-circulation of and co-infection by both viruses underscores the importance and urgency of developing vaccines against both viruses simultaneously.
  • Here we report the immunogenicity and protective efficacy of a bivalent combination vaccine comprised of EV71 and CA16 virus-like particles (VLPs).
  • We show that monovalent EV71- or CA16-VLPs-elicited serum antibodies exhibited potent neutralization effect on the homotypic virus but little or no effect on the heterotypic one, whereas the antisera against the bivalent vaccine formulation were able to efficiently neutralize both EV71 and CA16, indicating there is no immunological interference between the two antigens with respect to their ability to induce virus-specific neutralizing antibodies.
  • Passive immunization with monovalent VLP vaccines protected mice against a homotypic virus challenge but not heterotypic infection.
  • Surprisingly, antibody-dependent enhancement (ADE) of disease was observed in mice passively transferred with mono-specific anti-CA16 VLP sera and subsequently challenged with EV71.
  • [MeSH-major] Coxsackievirus Infections / prevention & control. Enterovirus Infections / prevention & control. Viral Vaccines / immunology
  • [MeSH-minor] Animals. Animals, Newborn. Antibodies, Neutralizing / blood. Antibodies, Viral / blood. Antibody Formation. Enterovirus / immunology. Enterovirus A, Human / immunology. Female. Immunity, Maternally-Acquired. Immunization, Passive. Mice, Inbred ICR. Neutralization Tests. Vaccines, Virus-Like Particle / immunology

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  • [Copyright] Copyright © 2014 Elsevier Ltd. All rights reserved.
  • (PMID = 24950363.001).
  • [ISSN] 1873-2518
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Neutralizing; 0 / Antibodies, Viral; 0 / Vaccines, Virus-Like Particle; 0 / Viral Vaccines
  • [Keywords] NOTNLM ; Coxsackievirus A16 / Enterovirus 71 / Neutralizing antibody / Vaccine / Virus-like particle
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42. Jia L, Zhao CS, Zhang L, Li S, Zhang DT, Liu BW, Wang QY, Li XY: [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16]. Zhongguo Dang Dai Er Ke Za Zhi; 2011 Aug;13(8):635-7
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  • [Title] [Comparisons of epidemiological and clinical characteristics in children with hand-foot-mouth disease caused by Enterovirus 71 and Coxackievirus A16].
  • OBJECTIVE: To compare the differences of epidemiological and clinical characteristics in children with hand-foot-mouth disease (HFMD) caused by Coxsackievirus A16 (CA16) and Enterovirus 71 (EV71).
  • The clinical data of children with EV71 and CA16 infection were retrospectively reviewed and compared.
  • The multivariate logistic regression analysis showed that the HFMD children who had erythra of knees had higher probability of CA16 infection.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Enterovirus A, Human. Hand, Foot and Mouth Disease / epidemiology

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  • (PMID = 21849112.001).
  • [ISSN] 1008-8830
  • [Journal-full-title] Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
  • [ISO-abbreviation] Zhongguo Dang Dai Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] China
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43. Zong W, He Y, Yu S, Yang H, Xian H, Liao Y, Hu G: Molecular phylogeny of Coxsackievirus A16 in Shenzhen, China, from 2005 to 2009. J Clin Microbiol; 2011 Apr;49(4):1659-61
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  • [Title] Molecular phylogeny of Coxsackievirus A16 in Shenzhen, China, from 2005 to 2009.
  • Phylogenetic analysis of a Coxsackievirus A16 (CA16) sequence from Shenzhen, China, and other Chinese and international CA16 sequences revealed a pattern of endemic cocirculation of strains of clusters B2a and B2b within subtype B2 viruses.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Coxsackievirus Infections / virology. Enterovirus / classification. Enterovirus / genetics
  • [MeSH-minor] Amino Acid Substitution / genetics. China / epidemiology. Cluster Analysis. Evolution, Molecular. Humans. Molecular Epidemiology. Molecular Sequence Data. Mutation, Missense. Phylogeny. RNA, Viral / genetics. Sequence Analysis, DNA

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  • [ISSN] 1098-660X
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  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ HM776219/ HM776220/ HM776221/ HM776222/ HM776223/ HM776224/ HM776225/ HM776226/ HM776227/ HM776228/ HM776229/ HM776230/ HM776231/ HM776232/ HM776233/ HM776234/ HM776235/ HM776236/ HM776237/ HM776238/ HM776239/ HM776240/ HM776241/ HM776242/ HM776243/ HM776244/ HM776245/ HM776246/ HM776247/ HM776248/ HM776249/ HM776250/ HM776251/ HM776252/ HM776253/ HM776254/ HM776255/ HM776256/ HM776257/ HM776258/ HM776259/ HM776260/ HM776261/ HM776262/ HM776263/ HM776264/ HM776265/ HM776266/ HM776267/ HM776268/ HM776269/ HM776270/ HM776271/ HM776272/ HM776273/ HM776274/ HM776275/ HM776276/ HM776277/ HM776278/ HM776279/ HM776280/ HM776281/ HM776282/ HM776283/ HM776284/ HM776285/ HM776286/ HM776287/ HM776288/ HM776289/ HM776290/ HM776291/ HM776292/ HM776293/ HM776294/ HM776295/ HM776296/ HM776297/ HM776298/ HM776299/ HM776300/ HM776301/ HM776302/ HM776303/ HM776304/ HM776305/ HM776306/ HM776307/ HM776308/ HM776309/ HM776310/ HM776311/ HM776312/ HM776313/ HM776314/ HM776315/ HM776316/ HM776317/ HM776318/ HM776319/ HM776320/ HM776321/ HM776322/ HM776323/ HM776324/ HM776325/ HM776326/ HM776327/ HM776328/ HM776329/ HM776330/ HM776331/ HM776332/ HM776333/ HM776334/ HM776335/ HM776336/ HM776337/ HM776338/ HM776339/ HM776340/ HM776341/ HM776342/ HM776343/ HM776344/ HM776345/ HM776346/ HM776347/ HM776348/ HM776349/ HM776350/ HM776351/ HM776352/ HM776353/ HM776354/ HM776355/ HM776356/ HM776357/ HM776358/ HM776359/ HM776360/ HM776361/ HM776362/ HM776363/ HM776364/ HM776365/ HM776366/ HM776367/ HM776368/ HM776369/ HM776370/ HM776371/ HM776372/ HM776373/ HM776374/ HM776375/ HM776376/ HM776377/ HM776378/ HM776379/ HM776380/ HM776381/ HM776382/ HM776383/ HM776384/ HM776385/ HM776386/ HM776387/ HM776388/ HM776389/ HM776390/ HM776391/ HM776392/ HM776393/ HM776394/ HM776395/ HM776396/ HM776397/ HM776398/ HM776399/ HM776400/ HM776401/ HM776402/ HM776403/ HM776404/ HM776405/ HM776406/ HM776407/ HM776408/ HM776409/ HM776410/ HM776411/ HM776412/ HM776413/ HM776414/ HM776415/ HM776416/ HM776417/ HM776418/ HM776419/ HM776420/ HM776421/ HM776422/ HM776423/ HM776424/ HM776425/ HM776426/ HM776427/ HM776428/ HM776429/ HM776430/ HM776431/ HM776432/ HM776433/ HM776434/ HM776435/ HM776436/ HM776437/ HM776438/ HM776439/ HM776440/ HM776441/ HM776442/ HM776443/ HM776444/ HM776445/ HM776446/ HM776447/ HM776448/ HM776449/ HM776450/ HM776451/ HM776452/ HM776453/ HM776454/ HM776455/ HM776456/ HM776457/ HM776458/ HM776459/ HM776460/ HM776461/ HM776462/ HM776463/ HM776464/ HM776465/ HM776466/ HM776467/ HM776468/ HM776469/ HM776470/ HM776471/ HM776472/ HM776473/ HM776474/ HM776475/ HM776476/ HM776477/ HM776478/ HM776479/ HM776480/ HM776481/ HM776482/ HM776483/ HM776484/ HM776485/ HM776486/ HM776487/ HM776488/ HM776489/ HM776490/ HM776491/ HM776492/ HM776493/ HM776494/ HM776495/ HM776496/ HM776497/ HM776498/ HM776499/ HM776500/ HM776501/ HM776502/ HM776503/ HM776504/ HM776505/ HM776506/ HM776507/ HM776508/ HM776509/ HM776510/ HM776511/ HM776512/ HM776513/ HM776514/ HM776515/ HM776516/ HM776517/ HM776518/ HM776519/ HM776520/ HM776521/ HM776522/ HM776523/ HM776524/ HM776525/ HM776526/ HM776527/ HM776528/ HM776529/ HM776530/ HM776531/ HM776532/ HM776533/ HM776534/ HM776535/ HM776536/ HM776537/ HM776538/ HM776539/ HM776540/ HM776541/ HM776542/ HM776543/ HM776544/ HM776545/ HM776546/ HM776547/ HM776548/ HM776549/ HM776550/ HM776551/ HM776552/ HM776553/ HM776554/ HM776555/ HM776556/ HM776557/ HM776558/ HM776559/ HM776560/ HM776561/ HM776562/ HM776563/ HM776564/ HM776565/ HM776566/ HM776567/ HM776568/ HM776569/ HM776570/ HM776571/ HM776572/ HM776573/ HM776574/ HM776575/ HM776576/ HM776577/ HM776578/ HM776579/ HM776580/ HM776581/ HM776582/ HM776583/ HM776584/ HM776585/ HM776586/ HM776587/ HM776588/ HM776589/ HM776590/ HM776591/ HM776592/ HM776593/ HM776594/ HM776595/ HM776596/ HM776597/ HM776598/ HM776599/ HM776600/ HM776601/ HM776602/ HM776603/ HM776604/ HM776605/ HM776606/ HM776607/ HM776608/ HM776609/ HM776610/ HM776611/ HM776612/ HM776613/ HM776614/ HM776615/ HM776616/ HM776617/ HM776618/ HM776619/ HM776620/ HM776621/ HM776622/ HM776623/ HM776624/ HM776625/ HM776626/ HM776627/ HM776628/ HM776629/ HM776630/ HM776631/ HM776632/ HM776633/ HM776634/ HM776635/ HM776636/ HM776637/ HM776638/ HM776639/ HM776640/ HM776641/ HM776642/ HM776643/ HM776644/ HM776645/ HM776646/ HM776647/ HM776648/ HM776649/ HM776650/ HM776651/ HM776652/ HM776653/ HM776654/ HM776655/ HM776656/ HM776657/ HM776658/ HM776659/ HM776660/ HM776661/ HM776662/ HM776663/ HM776664/ HM776665/ HM776666/ HM776667/ HM776668/ HM776669/ HM776670/ HM776671/ HM776672/ HM776673/ HM776674/ HM776675/ HM776676/ HM776677/ HM776678/ HM776679/ HM776680/ HM776681/ HM776682/ HM776683/ HM776684/ HM776685/ HM776686/ HM776687/ HM776688/ HM776689/ HM776690/ HM776691/ HM776692/ HM776693/ HM776694/ HM776695/ HM776696/ HM776697/ HM776698/ HM776699/ HM776700/ HM776701/ HM776702/ HM776703/ HM776704/ HM776705/ HM776706/ HM776707/ HM776708/ HM776709/ HM776710/ HM776711/ HM776712/ HM776713/ HM776714/ HM776715/ HM776716/ HM776717/ HM776718/ HM776719/ HM776720/ HM776721/ HM776722/ HM776723/ HM776724/ HM776725/ HM776726/ HM776727/ HM776728/ HM776729/ HM776730/ HM776731/ HM776732/ HM776733/ HM776734/ HM776735/ HM776736/ HM776737/ HM776738/ HM776739/ HM776740/ HM776741/ HM776742/ HM776743/ HM776744/ HM776745/ HM776746/ HM776747/ HM776748/ HM776749/ HM776750/ HM776751/ HM776752/ HM776753/ HM776754/ HM776755/ HM776756/ HM776757/ HM776758/ HM776759/ HM776760/ HM776761/ HM776762/ HM776763/ HM776764/ HM776765/ HM776766/ HM776767/ HM776768/ HM776769/ HM776770/ HM776771/ HM776772/ HM776773/ HM776774/ HM776775/ HM776776/ HM776777/ HM776778/ HM776779/ HM776780/ HM776781/ HM776782/ HM776783/ HM776784/ HM776785/ HM776786/ HM776787/ HM776788/ HM776789/ HM776790/ HM776791/ HM776792/ HM776793/ HM776794/ HM776795/ HM776796/ HM776797/ HM776798/ HM776799/ HM776800/ HM776801/ HM776802/ HM776803/ HM776804/ HM776805/ HM776806/ HM776807/ HM776808/ HM776809/ HM776810/ HM776811/ HM776812/ HM776813/ HM776814/ HM776815/ HM776816/ HM776817/ HM776818/ HM776819/ HM776820/ HM776821/ HM776822/ HM776823/ HM776824/ HM776825/ HM776826/ HM776827/ HM776828/ HM776829/ HM776830/ HM776831/ HM776832/ HM776833/ HM776834/ HM776835/ HM776836/ HM776837/ HM776838/ HM776839/ HM776840/ HM776841/ HM776842/ HM776843/ HM776844/ HM776845/ HM776846/ HM776847/ HM776848/ HM776849/ HM776850/ HM776851/ HM776852/ HM776853/ HM776854/ HM776855/ HM776856/ HM776857/ HM776858/ HM776859/ HM776860/ HM776861/ HM776862/ HM776863/ HM776864/ HM776865/ HM776866/ HM776867/ HM776868/ HM776869/ HM776870/ HM776871/ HM776872/ HM776873/ HM776874/ HM776875/ HM776876/ HM776877/ HM776878/ HM776879/ HM776880/ HM776881/ HM776882/ HM776883/ HM776884/ HM776885/ HM776886/ HM776887/ HM776888/ HM776889/ HM776890/ HM776891/ HM776892/ HM776893/ HM776894/ HM776895/ HM776896/ HM776897/ HM776898/ HM776899/ HM776900/ HM776901/ HM776902/ HM776903/ HM776904/ HM776905/ HM776906/ HM776907/ HM776908/ HM776909/ HM776910/ HM776911/ HM776912/ HM776913/ HM776914/ HM776915/ HM776916/ HM776917/ HM776918/ HM776919/ HM776920/ HM776921/ HM776922/ HM776923/ HM776924/ HM776925/ HM776926/ HM776927/ HM776928/ HM776929/ HM776930/ HM776931/ HM776932/ HM776933/ HM776934/ HM776935/ HM776936/ HM776937/ HM776938/ HM776939/ HM776940/ HM776941/ HM776942/ HM776943/ HM776944/ HM776945/ HM776946/ HM776947/ HM776948/ HM776949/ HM776950/ HM776951/ HM776952/ HM776953/ HM776954/ HM776955/ HM776956/ HM776957/ HM776958/ HM776959/ HM776960/ HM776961/ HM776962/ HM776963/ HM776964/ HM776965/ HM776966/ HM776967/ HM776968/ HM776969/ HM776970/ HM776971/ HM776972/ HM776973/ HM776974/ HM776975/ HM776976/ HM776977/ HM776978/ HM776979/ HM776980/ HM776981/ HM776982/ HM776983/ HM776984/ HM776985/ HM776986/ HM776987/ HM776988/ HM776989/ HM776990/ HM776991/ HM776992/ HM776993/ HM776994/ HM776995/ HM776996/ HM776997/ HM776998/ HM776999/ HM777000/ HM777001/ HM777002/ HM777003/ HM777004/ HM777005/ HM777006/ HM777007/ HM777008/ HM777009/ HM777010/ HM777011/ HM777012/ HM777013/ HM777014/ HM777015/ HM777016/ HM777017/ HM777018/ HM777019/ HM777020/ HM777021/ HM777022/ HM777023/ HM777024/ HM777025/ HM777026/ HM777027/ HM777028/ HM777029/ HM777030/ HM777031/ HM777032/ HM777033/ HM777034/ HM777035/ HM777036/ HM777037/ HM777038/ HM777039/ HM777040/ HM777041/ HM777042/ HM777043/ HM777044/ HM777045/ HM777046/ HM777047/ HM777048/ HM777049/ HM777050/ HM777051/ HM777052/ HM777053/ HM777054/ HM777055/ HM777056/ HM777057/ HM777058/ HM777059/ HM777060/ HM777061/ HM777062/ HM777063/ HM777064/ HM777065/ HM777066/ HM777067/ HM777068/ HM777069/ HM777070/ HM777071/ HM777072/ HM777073/ HM777074/ HM777075/ HM777076/ HM777077/ HM777078/ HM777079/ HM777080/ HM777081/ HM777082/ HM777083/ HM777084/ HM777085/ HM777086/ HM777087/ HM777088/ HM777089/ HM777090/ HM777091/ HM777092/ HM777093/ HM777094/ HM777095/ HM777096/ HM777097/ HM777098/ HM777099/ HM777100/ HM777101/ HM777102/ HM777103/ HM777104/ HM777105/ HM777106/ HM777107/ HM777108/ HM777109/ HM777110/ HM777111/ HM777112/ HM777113/ HM777114/ HM777115/ HM777116/ HM777117/ HM777118/ HM777119/ HM777120/ HM777121/ HM777122/ HM777123/ HM777124/ HM777125/ HM777126/ HM777127/ HM777128/ HM777129/ HM777130/ HM777131/ HM777132/ HM777133/ HM777134/ HM777135/ HM777136/ HM777137/ HM777138/ HM777139/ HM777140/ HM777141/ HM777142/ HM777143/ HM777144/ HM777145/ HM777146/ HM777147/ HM777148/ HM777149/ HM777150/ HM777151/ HM777152/ HM777153/ HM777154/ HM777155/ HM777156/ HM777157/ HM777158/ HM777159/ HM777160/ HM777161/ HM777162/ HM777163/ HM777164/ HM777165/ HM777166/ HM777167/ HM777168/ HM777169/ HM777170/ HM777171/ HM777172/ HM777173/ HM777174/ HM777175/ HM777176/ HM777177/ HM777178/ HM777179/ HM777180/ HM777181/ HM777182/ HM777183/ HM777184/ HM777185/ HM777186/ HM777187/ HM777188/ HM777189/ HM777190/ HM777191/ HM777192/ HM777193/ HM777194/ HM777195/ HM777196/ HM777197/ HM777198/ HM777199/ HM777200/ HM777201/ HM777202/ HM777203/ HM777204/ HM777205/ HM777206/ HM777207/ HM777208/ HM777209/ HM777210/ HM777211/ HM777212/ HM777213/ HM777214/ HM777215/ HM777216/ HM777217/ HM777218
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC3122795
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44. Kim H, Kang B, Hwang S, Hong J, Chung J, Kim S, Jeong YS, Kim K, Cheon DS: Molecular characteristics of human coxsackievirus B1 infection in Korea, 2008-2009. J Med Virol; 2013 Jan;85(1):110-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular characteristics of human coxsackievirus B1 infection in Korea, 2008-2009.
  • This study was performed to analyze epidemiological and molecular characteristics of coxsakievirus (CV) B1 infection associated with severe neonatal illness cases and death in Korea during 2008-2009.
  • The other clinical symptoms were herpangina or hand-foot-mouth disease (22.1%) and neonatal sepsis (7.7%).
  • The identification of CVB1 in South Korea shows the potential of EVs to cause serious disease in an unpredictable fashion.
  • [MeSH-major] Coxsackievirus Infections / epidemiology. Coxsackievirus Infections / virology. Enterovirus / classification. Enterovirus / isolation & purification
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cluster Analysis. Female. Genotype. Humans. Infant. Male. Molecular Epidemiology. Molecular Sequence Data. Phylogeny. Polymerase Chain Reaction. RNA, Viral / genetics. Real-Time Polymerase Chain Reaction. Republic of Korea / epidemiology. Sequence Analysis, DNA. Sequence Homology, Amino Acid. Viral Structural Proteins / genetics

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • [ErratumIn] J Med Virol. 2013 May;85(5):939
  • [ErratumIn] J Med Virol. 2013 Aug;85(8):1498
  • (PMID = 23073968.001).
  • [ISSN] 1096-9071
  • [Journal-full-title] Journal of medical virology
  • [ISO-abbreviation] J. Med. Virol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ JN638300/ JN638301/ JN638302/ JN638303/ JN638304/ JN638305/ JN638306/ JN638307/ JN638308/ JN638309/ JN638310/ JQ235663/ JQ235664/ JQ235665/ JQ235666/ JQ235667/ JQ235668/ JQ235669/ JQ235670/ JQ235671/ JQ235672/ JQ235673/ JQ235674/ JQ235675/ JQ235676/ JQ235677/ JQ235678/ JQ235679/ JQ235680/ JQ235681/ JQ235682/ JQ235683/ JQ235684/ JQ235685/ JQ235686/ JQ235687/ JQ235688/ JQ235689
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral; 0 / Viral Structural Proteins
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45. Cooper IF, Siadaty MS: 'Pharmacologic Substances' associated with 'Coxsackie Virus Infection': Top Publications. BioMedLib Review; PharmacologicSubstance;CoxsackieVirusInfection:706082900. ISSN: 2331-5717. 2014/12/22
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  • [Title] 'Pharmacologic Substances' associated with 'Coxsackie Virus Infection': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Pharmacologic Substance' for 'coxsackie virus infection'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Pharmacologic Substance'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 30 publications, and group two 6248 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Amino Acids, Peptides, or Proteins' associated with 'Coxsackie Virus Infection': Top Publications.
  • Rager-Zisman B et al: Effects of immunosuppression on coxsackie B-3 virus infection in mice, and passive protection by circulating antibody.
  • Rager-Zisman B et al: The role of antibody and host cells in the resistance of mice against infection by coxsackie B-3 virus.
  • Fechner H et al: Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections.
  • Galabov AS et al: Antiviral activity of N-phenyl-N'-aryl- or alkylthiourea derivatives in Coxsackie virus infections in mice.
  • Wessely R et al: Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication.
  • Huber SA et al: Influence of sex hormones on Coxsackie B-3 virus infection in Balb/c mice.
  • Al-Hello H et al: Amino acids of Coxsackie B5 virus are critical for infection of the murine insulinoma cell line, MIN-6.
  • Berg AK et al: Antiviral treatment of Coxsackie B virus infection in human pancreatic islets.
  • Yuan W: [Effects of Coxsackie B-2 virus infection on electrophysiologic properties of beating cultured rat heart cells].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706082900.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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46. Savasteeva NV, Zhukova VA, Travin MA, Nadeev AP: [A case of congenital Coxsackie B virus infection]. Arkh Patol; 2014 May-Jun;76(3):80-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of congenital Coxsackie B virus infection].
  • The paper describes a clinical case of congenital Coxsackie B virus infection in a girl aged 1 month and 15 days of life who has undergone a detailed postmortem examination.
  • [MeSH-major] Coxsackievirus Infections / pathology. Enterovirus B, Human / pathogenicity

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  • (PMID = 25306616.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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48. Shea YF, Chan CY, Hung IF, Chan KH: Hand, foot and mouth disease in an immunocompetent adult due to Coxsackievirus A6. Hong Kong Med J; 2013 Jun;19(3):262-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hand, foot and mouth disease in an immunocompetent adult due to Coxsackievirus A6.
  • Hand, foot and mouth disease most commonly occurs in children less than 10 years old, but can occur in immunocompetent adults.
  • Real-time polymerase chain reaction revealed Coxsackievirus A6 in the vesicle fluid from the feet, throat swab, and rectal swab.
  • Since the disease is highly contagious, to contain the infection it is prudent to recognise that hand, foot and mouth disease can occur in immunocompetent adults.
  • [MeSH-major] Coxsackievirus Infections / complications. Enterovirus A, Human / isolation & purification. Hand, Foot and Mouth Disease / virology

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  • (PMID = 23732432.001).
  • [ISSN] 1024-2708
  • [Journal-full-title] Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
  • [ISO-abbreviation] Hong Kong Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Keywords] NOTNLM ; Hand, foot and mouth disease
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49. Miyamoto A, Hirata R, Ishimoto K, Hisatomi M, Wasada R, Akita Y, Ishihara T, Fujimoto T, Eshima N, Hatano Y, Katagiri K, Fujiwara S: An outbreak of hand-foot-and-mouth disease mimicking chicken pox, with a frequent association of onychomadesis in Japan in 2009: a new phenotype caused by coxsackievirus A6. Eur J Dermatol; 2014 Jan-Feb;24(1):103-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An outbreak of hand-foot-and-mouth disease mimicking chicken pox, with a frequent association of onychomadesis in Japan in 2009: a new phenotype caused by coxsackievirus A6.
  • [MeSH-major] Chickenpox / diagnosis. Disease Outbreaks. Hand, Foot and Mouth Disease / diagnosis. Hand, Foot and Mouth Disease / epidemiology
  • [MeSH-minor] Child, Preschool. Coxsackievirus Infections / complications. Diagnosis, Differential. Female. Humans. Infant. Japan / epidemiology. Male. Nail Diseases / virology. Phenotype

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  • (PMID = 24334231.001).
  • [ISSN] 1952-4013
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] France
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50. Rose NR: Critical cytokine pathways to cardiac inflammation. J Interferon Cytokine Res; 2011 Oct;31(10):705-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Infectious disease is frequently cited as a precursor of subsequent autoimmune disease in genetically susceptible hosts.
  • However, the precise mechanisms required for the transition from infection to autoimmunity have not been well defined.
  • We have developed a mouse model of autoimmune myocarditis initiated by infection with Coxsackievirus B3 to trace the cytokine pathways involved.
  • We found that greater production of interleukin-1β (IL-1β) and tumor necrosis factor-α during the early innate response to virus infection is necessary and sufficient to induce a later heart-specific autoimmune disease.
  • Severity of the autoimmune myocarditis is determined by the profile of a number of T helper 1 (Th1) and Th2 cytokines.
  • Th17 cytokines also contribute to disease, but the signature Th17 cytokine, IL-17A, is not required for cardiac inflammation.
  • These findings may provide useful markers to identify individuals prone to develop an autoimmune sequel after infection and suggest future early interventions.
  • [MeSH-major] Autoimmune Diseases / immunology. Cytokines / immunology. Immunity, Innate. Myocarditis / immunology. Myocardium / immunology. T-Lymphocytes, Helper-Inducer / immunology
  • [MeSH-minor] Animals. Coxsackievirus Infections / complications. Coxsackievirus Infections / immunology. Coxsackievirus Infections / pathology. Disease Models, Animal. Enterovirus B, Human / immunology. Humans. Mice

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  • (PMID = 21861699.001).
  • [ISSN] 1557-7465
  • [Journal-full-title] Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • [ISO-abbreviation] J. Interferon Cytokine Res.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI151835; United States / NHLBI NIH HHS / HL / HL67290; United States / NHLBI NIH HHS / HL / HL70729
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytokines
  • [Other-IDs] NLM/ PMC3189548
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