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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||||||. 100%  Cronnolly B, Pegrum H: Fentanyl-clarithromycin interaction. BMJ Case Rep; 2012;2012
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fentanyl-clarithromycin interaction.
  • This case describes an incident where a patient with breast cancer and bone metastases, who was using a fentanyl patch, was started on a course of clarithromycin and experienced a respiratory arrest 2 days later.
  • She was a hospital inpatient at the time and was treated with naloxone and the fentanyl patch was stopped at the time of the reaction.
  • She recovered but was left without pain relief until seen in clinic by the palliative care consultant who restarted the fentanyl patch without further problems.
  • [MeSH-major] Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Clarithromycin / therapeutic use. Fentanyl / therapeutic use

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  • [Cites] J Pain Symptom Manage. 2009 Jun;37(6):e2-5 [19500718.001]
  • (PMID = 22778456.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Anti-Bacterial Agents; H1250JIK0A / Clarithromycin; UF599785JZ / Fentanyl
  • [Other-IDs] NLM/ PMC3417012
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2. |||||||||. 89%  Olson KN, Luckenbill K, Thompson J, Middleton O, Geiselhart R, Mills KM, Kloss J, Apple FS: Postmortem redistribution of fentanyl in blood. Am J Clin Pathol; 2010 Mar;133(3):447-53
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  • [Title] Postmortem redistribution of fentanyl in blood.
  • Fentanyl concentrations were measured in postmortem specimens collected in 20 medical examiner cases from femoral blood (FB), heart blood (HB), heart tissue, liver tissue, and skeletal muscle.
  • Fentanyl concentrations for FB1 and FB2 ranged from undetectable to 14.6 microg/L (mean, 4.6 microg/L) and 2.0 to 52.5 microg/L (mean, 17.3 microg/L), respectively.
  • Corresponding mean HB, liver tissue, and heart tissue fentanyl concentrations were 29.8 microg/L, 109.7 mg/kg, and 103.4 mg/kg, respectively.
  • The fentanyl HB/FB1 ratio (mean, 8.39) was higher compared with the corresponding HB/FB2 ratio (mean, 3.48).
  • These results suggest that postmortem redistribution of fentanyl can occur in FB.
  • [MeSH-major] Autopsy. Fentanyl / pharmacokinetics. Postmortem Changes

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  • (PMID = 20154283.001).
  • [ISSN] 1943-7722
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Narcotics; UF599785JZ / Fentanyl
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3. |||||||||. 87%  Nelson L, Schwaner R: Transdermal fentanyl: pharmacology and toxicology. J Med Toxicol; 2009 Dec;5(4):230-41
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  • [Title] Transdermal fentanyl: pharmacology and toxicology.
  • OBJECTIVE: To evaluate the underlying pharmacology, safety, and misuse/abuse of transdermal fentanyl, one of the cornerstone pharmacotherapies for patients with chronic pain.
  • Search terms included combinations of the following: fentanyl, transdermal, patch, pharmacology, kinetics, toxicity, and poisoning.
  • All pertinent clinical trials, retrospective studies, and case reports relevant to fentanyl pharmacology and transdermal fentanyl administered by any route and published in English were identified.
  • Each was reviewed for data regarding the clinical pharmacology, abuse, misuse, and safety of transdermal fentanyl.
  • RESULTS: Fentanyl is a high-potency opioid that has many uses in the treatment of both acute and chronic pain.
  • Both the US Food and Drug Administration (FDA) and Health Canada have warned of potential pitfalls associated with transdermal fentanyl, although these have not been completely effective in preventing life-threatening adverse events and fatalities related to its inappropriate use.
  • CONCLUSIONS: Clinically consequential adverse effects may occur unexpectedly with normal use of transdermal fentanyl, or if misused or abused.
  • [MeSH-major] Analgesics, Opioid / administration & dosage. Analgesics, Opioid / poisoning. Fentanyl / administration & dosage. Fentanyl / poisoning. Opioid-Related Disorders / etiology. Pain / drug therapy

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  • (PMID = 19876859.001).
  • [ISSN] 1556-9039
  • [Journal-full-title] Journal of medical toxicology : official journal of the American College of Medical Toxicology
  • [ISO-abbreviation] J Med Toxicol
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Drug Carriers; UF599785JZ / Fentanyl
  • [Number-of-references] 114
  • [Other-IDs] NLM/ PMC3550407
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4. ||||||||.. 82%  Cooper IF, Siadaty MS: 'Steroids' associated with 'Bupivacaine Fentanyl': Top Publications. BioMedLib Review; Steroid;BupivacaineFentanyl:705815139. ISSN: 2331-5717. 2014/4/28
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  • [Title] 'Steroids' associated with 'Bupivacaine Fentanyl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'steroid' for 'bupivacaine fentanyl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'steroid'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 25 publications, and group two 1012 publications.
  • Here are the top 10.
  • Ben-David B et al: Minidose bupivacaine-fentanyl spinal anesthesia for surgical repair of hip fracture in the aged.
  • Hennebry MC et al: Effect of i.v. phenylephrine or ephedrine on the ED50 of intrathecal bupivacaine with fentanyl for caesarean section.
  • Black AS et al: Spinal anaesthesia for ambulatory arthroscopic surgery of the knee: a comparison of low-dose prilocaine and fentanyl with bupivacaine and fentanyl.
  • Safari F et al: The effect of adjuvant midazolam compared with fentanyl on the duration of spinal anesthesia with 0.5% bupivacaine in opium abusers.
  • Stocks GM et al: Minimum local analgesic dose of intrathecal bupivacaine in labor and the effect of intrathecal fentanyl.
  • Polley LS et al: Effect of intravenous versus epidural fentanyl on the minimum local analgesic concentration of epidural bupivacaine in labor.
  • Canan U et al: Comparison of the maternal and neonatal effects of bupivacaine plus fentanyl and ropivacaine plus fentanyl during cesarean delivery.
  • Turkmen A et al: Comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl and bupivacaine + fentanyl during caesarean section.
  • Gaitini LA et al: Does the addition of fentanyl to bupivacaine in caudal epidural block have an effect on the plasma level of catecholamines in children?.
  • McCrory C et al: Comparison between repeat bolus intrathecal morphine and an epidurally delivered bupivacaine and fentanyl combination in the management of post-thoracotomy pain with or without cyclooxygenase inhibition.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705815139.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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5. |||||||||. 87%  Ai Q, Hu Y, Wang Y, Wu S, Qin Z, Wang J, Wang G, Zhang J, An M: Pentazocine pretreatment suppresses fentanyl-induced cough. Pharmacol Rep; 2010 Jul-Aug;62(4):747-50
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  • [Title] Pentazocine pretreatment suppresses fentanyl-induced cough.
  • This study evaluated the effect of pentazocine pretreatment on fentanyl-induced cough.
  • Group I (n = 92) and Group II (n = 93) received normal saline, while Group III (n = 92) received pentazocine 0.5 mg·kg(-1) 5 min prior to receiving fentanyl, Patients belonging to Groups II and III were administered 2 μg/kg fentanyl intravenously over 2 s after the first injection; Group I served as a negative control for fentanyl.
  • Physiologic indicators such as heart rate (HR), non-invasive blood pressure (NBP) and pulse oximetry oxygen saturation (SpO(2)) of patients were recorded before giving pentazocine or normal saline 1 minute after fentanyl injections.
  • Premedication with intravenous pentazocine can minimize the incidence of fentanyl-induced cough and has no influence on blood pressure, heart rate, and SpO(2) compared with Group II.
  • [MeSH-major] Anesthetics, Intravenous / adverse effects. Cough / prevention & control. Fentanyl / adverse effects. Pentazocine / therapeutic use

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  • (PMID = 20885016.001).
  • [ISSN] 1734-1140
  • [Journal-full-title] Pharmacological reports : PR
  • [ISO-abbreviation] Pharmacol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; 0 / Narcotic Antagonists; RP4A60D26L / Pentazocine; UF599785JZ / Fentanyl
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6. |||||||||. 85%  Lera dos Santos ME, Maluf-Filho F, Chaves DM, Matuguma SE, Ide E, Luz Gde O, de Souza TF, Pessorrusso FC, de Moura EG, Sakai P: Deep sedation during gastrointestinal endoscopy: propofol-fentanyl and midazolam-fentanyl regimens. World J Gastroenterol; 2013 Jun 14;19(22):3439-46
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  • [Title] Deep sedation during gastrointestinal endoscopy: propofol-fentanyl and midazolam-fentanyl regimens.
  • AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy.
  • Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).
  • RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofol-fentanyl group than the midazolam-fentanyl group.
  • According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014).
  • Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolam-fentanyl group according to the BIS scale (P = 0.039).
  • Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025).
  • The mean time to recovery was 28.82 and 44.13 min in the propofol-fentanyl and midazolam-fentanyl groups, respectively (P < 0.001).
  • Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination.
  • CONCLUSION: Deep sedation occurred with propofol-fentanyl and midazolam-fentanyl, but was more frequent in the former.
  • Recovery was faster in the propofol-fentanyl group.
  • [MeSH-major] Anesthetics, Combined / administration & dosage. Anesthetics, Intravenous / administration & dosage. Deep Sedation / methods. Endoscopy, Gastrointestinal. Fentanyl / administration & dosage. Hypnotics and Sedatives / administration & dosage. Midazolam / administration & dosage. Propofol / administration & dosage

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  • (PMID = 23801836.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology : WJG
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Anesthetics, Combined; 0 / Anesthetics, Intravenous; 0 / Hypnotics and Sedatives; R60L0SM5BC / Midazolam; UF599785JZ / Fentanyl; YI7VU623SF / Propofol
  • [Other-IDs] NLM/ PMC3683682
  • [Keywords] NOTNLM ; Adverse effects / Anesthetic administration / Anesthetic dose / Deep sedation / Endoscopy
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7. |||||||||. 87%  Weltrowska G, Chung NN, Lemieux C, Guo J, Lu Y, Wilkes BC, Schiller PW: "Carba"-analogues of fentanyl are opioid receptor agonists. J Med Chem; 2010 Apr 8;53(7):2875-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] "Carba"-analogues of fentanyl are opioid receptor agonists.
  • To further examine the role of this electrostatic interaction in receptor binding and activation, we synthesized "carba"-analogues of a published fentanyl analogue containing a 3-(guanidinomethyl)-benzyl group in place of the phenyl moiety attached to the ethylamido group (C.
  • In conjunction with performed receptor docking studies, these results indicate that the electrostatic interaction of the protonated nitrogen in the piperidine ring of fentanyl analogues with the Asp residue in the third TMH is not a conditio sine qua non for opioid receptor activation.
  • [MeSH-major] Fentanyl / analogs & derivatives. Fentanyl / pharmacology. Receptors, Opioid / agonists

  • HSDB. structure - GUANIDINE.
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  • (PMID = 20218625.001).
  • [ISSN] 1520-4804
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA-004443; Canada / Canadian Institutes of Health Research / / MOP-89716; United States / NIDA NIH HHS / DA / R01 DA004443; United States / NIDA NIH HHS / DA / R01 DA004443-22
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Opioid; JU58VJ6Y3B / Guanidine; UF599785JZ / Fentanyl
  • [Other-IDs] NLM/ NIHMS187024; NLM/ PMC2848705
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8. ||||||||.. 82%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Fentanyl Ropivacaine': Top Publications. BioMedLib Review; OrganicChemical;FentanylRopivacaine:706369140. ISSN: 2331-5717. 2014/7/26
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  • [Title] 'Organic Chemicals' associated with 'Fentanyl Ropivacaine': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organic Chemical' for 'fentanyl ropivacaine'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organic Chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 29 publications, and group two 256 publications.
  • Here are the top 10.
  • Kim S et al: Antiemetic effects of midazolam added to fentanyl-ropivacaine patient-controlled epidural analgesia after subtotal gastrectomy: A prospective, randomized, double-blind, controlled trial.
  • Ficklscherer A et al: Comparison of ropivacaine and fentanyl toxicity in human fibroblasts.
  • Chaudhary A et al: Efficacy of spinal ropivacaine versus ropivacaine with fentanyl in transurethral resection operations.
  • Fan Y et al: Comparison of epidural tramadol-ropivacaine and fentanyl-ropivacaine for labor analgesia: a prospective randomized study.
  • Canan U et al: Comparison of the maternal and neonatal effects of bupivacaine plus fentanyl and ropivacaine plus fentanyl during cesarean delivery.
  • Rastogi B et al: Hemiarthroplasty in high risk elderly patient under epidural anesthesia with 0.75% ropivacaine-fentanyl versus 0.5% bupivacaine-fentanyl: Clinical trial.
  • Panni MK et al: Minimum effective dose of spinal ropivacaine with and without fentanyl for postpartum tubal ligation.
  • Mousa WF et al: Epidural analgesia during labor--0.5% lidocaine with fentanyl vs. 0.08% ropivacaine with fentanyl.
  • Gunaydin B et al: Intrathecal hyperbaric or isobaric bupivacaine and ropivacaine with fentanyl for elective caesarean section.
  • Tveit TO et al: Labour analgesia: a randomised, controlled trial comparing intravenous remifentanil and epidural analgesia with ropivacaine and fentanyl.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706369140.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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9. |||||||||. 114%  Twycross R, Prommer EE, Mihalyo M, Wilcock A: Fentanyl (transmucosal). J Pain Symptom Manage; 2012 Jul;44(1):131-49
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fentanyl (transmucosal).
  • [MeSH-major] Analgesics, Opioid / therapeutic use. Fentanyl / therapeutic use. Pain / drug therapy

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  • [Copyright] Copyright © 2012. Published by Elsevier Inc.
  • (PMID = 22770488.001).
  • [ISSN] 1873-6513
  • [Journal-full-title] Journal of pain and symptom management
  • [ISO-abbreviation] J Pain Symptom Manage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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10. |||||||||. 106%  Shrestha SK, Bhattarai B, Shah RS: Preemptive use of small dose fentanyl suppresses fentanyl induced cough. Kathmandu Univ Med J (KUMJ); 2012 Oct-Dec;10(40):16-9
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  • [Title] Preemptive use of small dose fentanyl suppresses fentanyl induced cough.
  • BACKGROUND: Fentanyl, a synthetic opioid, is a popular choice amongst anaesthesiologists in the operating room.
  • Pre induction intravenous fentanyl bolus is associated with coughing in 28-65% of patients.
  • Fentanyl induced cough is not always benign and can be remarkably troublesome at the most critical moment of anaesthesia when airway reflex is lost.
  • OBJECTIVES: To study the effect of pre emptive use of minimal dose fentanyl through the peripheral venous cannulae on the incidence of cough by a larger bolus of intravenous fentanyl.
  • The first group received 0.5 ml saline 0.9% intravenously one minute prior to the administration of fentanyl 150 μg (3 ml); the second group received pre emptive fentanyl 25 μg (0.5 ml) prior to the administration of fentanyl 125 μg (2.5 ml); and the third group received preemptive fentanyl 25 μg (0.5 ml), followed by the administration of fentanyl 150 μg (3 ml).
  • RESULTS: The incidence of fentanyl induced cough was significantly lower in both pre emptive group 4 (8%) for 125 μg fentanyl and 7 (14%) for 150 μg than in the saline group 15 (30%).
  • CONCLUSION: Pre-emptive use of minimal dose fentanyl 25 μg administered one minute before a larger bolus dose of fentanyl (125 or 150 μg) can effectively suppress cough.
  • [MeSH-major] Analgesics, Opioid / administration & dosage. Analgesics, Opioid / adverse effects. Cough / prevention & control. Fentanyl / adverse effects

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  • (PMID = 23575046.001).
  • [ISSN] 1812-2078
  • [Journal-full-title] Kathmandu University medical journal (KUMJ)
  • [ISO-abbreviation] Kathmandu Univ Med J (KUMJ)
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] Nepal
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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11. |||||||||. 105%  Palmer RB: Fentanyl in postmortem forensic toxicology. Clin Toxicol (Phila); 2010 Oct;48(8):771-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fentanyl in postmortem forensic toxicology.
  • CONTEXT: Fentanyl is a powerful opioid used for the induction of anesthesia as well as for the management of severe pain.
  • In recent years, transdermal fentanyl "patches" have become popular for outpatient management of chronic pain.
  • The high potency and outpatient availability of fentanyl has also made it a highly sought-after drug of abuse.
  • Deaths in which fentanyl is detected challenge medical examiners who must decide whether a given case represents therapeutic administration or overdose.
  • OBJECTIVES: The current review seeks to present data about fentanyl that are relevant to the interpretation of postmortem blood and tissue fentanyl concentrations as well as to highlight areas which can be helpful or misleading in the evaluation of deaths potentially related to fentanyl exposure.
  • METHODS: Standard searching of the PubMed database for studies, case series, and case reports involving fentanyl kinetics, chemistry, and postmortem behavior was performed.
  • Search terms typically included "postmortem" and "fentanyl," as well as "kinetics" and "analysis," where appropriate.
  • RESULTS AND CONCLUSIONS: The postmortem behavior of fentanyl is influenced heavily by pH changes and the antemortem kinetic behavior of the drug, especially, by its distribution.
  • Postmortem blood fentanyl concentrations do not correlate directly with antemortem blood concentrations.
  • Without adequate evaluation of kinetic data, investigative information and consideration of postmortem changes, misinterpretation of postmortem fentanyl results is likely.
  • [MeSH-major] Analgesics, Opioid / blood. Fentanyl / blood. Forensic Toxicology

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  • (PMID = 20969499.001).
  • [ISSN] 1556-9519
  • [Journal-full-title] Clinical toxicology (Philadelphia, Pa.)
  • [ISO-abbreviation] Clin Toxicol (Phila)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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12. |||||||||. 105%  Roxburgh A, Burns L, Drummer OH, Pilgrim J, Farrell M, Degenhardt L: Trends in fentanyl prescriptions and fentanyl-related mortality in Australia. Drug Alcohol Rev; 2013 May;32(3):269-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in fentanyl prescriptions and fentanyl-related mortality in Australia.
  • INTRODUCTION AND AIMS: The study aims to quantify trends in fentanyl prescribing and fentanyl mortality in Australia within the context of concern among health professionals concerning increasing accessibility of fentanyl, and the harms that may arise as a result.
  • DESIGN AND METHODS: This paper presents data on prescribing patterns of fentanyl by 10 year age group adjusted by population rate, detailed analyses of fentanyl-related deaths from the National Coronial Information System and deaths adjusted for prescribing levels within Australia.
  • One hundred and thirty-six fentanyl-related deaths were recorded during 2000-2011; 54% of decedents had a history of injecting drug use and, among this group, 95% had injected fentanyl at the time of death; 62% of deaths recorded misuse (most notably injection) of fentanyl; 50% recorded a history of drug dependence and 40% a mental health problem; 37% recorded a history of chronic pain; and 36% recorded fentanyl as being prescribed at the time of death.
  • DISCUSSION AND CONCLUSIONS: There have been significant increases in fentanyl prescribing in Australia.
  • Fentanyl deaths have also increased, although mortality is currently low in Australia.
  • A large proportion of the deaths involved the injection of diverted fentanyl, highlighting the need for messages regarding safer injecting practices targeting people who inject drugs, and strategies to minimise the risks of diversion.
  • [MeSH-major] Analgesics, Opioid / adverse effects. Drug Prescriptions. Fentanyl / adverse effects. Opioid-Related Disorders / mortality

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  • [Copyright] © 2013 Australasian Professional Society on Alcohol and other Drugs.
  • (PMID = 23442164.001).
  • [ISSN] 1465-3362
  • [Journal-full-title] Drug and alcohol review
  • [ISO-abbreviation] Drug Alcohol Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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13. |||||||||. 104%  Moon JM, Chun BJ: Fentanyl intoxication caused by abuse of transdermal fentanyl. J Emerg Med; 2011 Jan;40(1):37-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fentanyl intoxication caused by abuse of transdermal fentanyl.
  • Fentanyl has an analgesic effect 100 times greater than that of morphine; therefore, transdermal administration of fentanyl has been widely used to control pain.
  • Due to misconceptions regarding the proper use of fentanyl, its simple method of administration, and the absence of regulatory rules regarding its use, both medical providers and non-medical providers have abused fentanyl.
  • We report on three cases of fentanyl intoxication and suggest solutions to prevent its abuse in the future.
  • Three patients were intoxicated by transdermal fentanyl, which resulted in respiratory depression.
  • Two of these cases were attributed to non-medical use of the drug and the other occurred while using fentanyl as directed by medical personnel.
  • Physicians should use transdermal fentanyl only to control chronic pain, and rules should be established to prevent abuse of fentanyl that occurs due to its ease of use and the absence of any established policy regarding the prescription and disposal of this drug.
  • [MeSH-major] Analgesics, Opioid / administration & dosage. Analgesics, Opioid / toxicity. Fentanyl / administration & dosage. Fentanyl / toxicity
  • [MeSH-minor] Administration, Cutaneous. Aged. Female. Humans. Male. Middle Aged. Substance-Related Disorders

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 18455903.001).
  • [ISSN] 0736-4679
  • [Journal-full-title] The Journal of emergency medicine
  • [ISO-abbreviation] J Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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14. |||||||||. 101%  Makazu H, Takahashi H, Suzuki T: [Fentanyl induced intraoperative anaphylactic reaction]. Masui; 2012 Oct;61(10):1141-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fentanyl induced intraoperative anaphylactic reaction].
  • We report a case of intraoperative fentanyl anaphylactic reaction.
  • We experienced a rapid hemodynamic change after fentanyl injection and that occurred again after another fentanyl injection.
  • We clinically diagnosed this as fentanyl anaphylactic reaction.
  • Six weeks later we performed prick test and intradermal test, but the patient had negative results for fentanyl in both tests.
  • [MeSH-major] Analgesics, Opioid / adverse effects. Anaphylaxis / chemically induced. Fentanyl / adverse effects. Intraoperative Complications / chemically induced

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  • (PMID = 23157106.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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15. |||||||||. 100%  KuKanich B: Pharmacokinetics of subcutaneous fentanyl in Greyhounds. Vet J; 2011 Nov;190(2):e140-2
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  • [Title] Pharmacokinetics of subcutaneous fentanyl in Greyhounds.
  • The purpose of the study was to describe the pharmacokinetics of subcutaneous fentanyl (15μg/kg) in six healthy Greyhound dogs.
  • Fentanyl plasma concentrations were determined by a liquid chromatography with mass spectrometry method.
  • Fentanyl was rapidly absorbed with a mean peak concentration (C(MAX)) of 3.56ng/mL at 0.24h.
  • Pain occurred on injection in all six dogs, but addition of 8.4% sodium bicarbonate (1mL per 20mL fentanyl) resulted in no pain on injection in 3/3 dogs but similar C(MAX) values.
  • The subcutaneous route may be an alternative route of fentanyl administration if intravenous administration is not practical.
  • [MeSH-major] Analgesics, Opioid / pharmacokinetics. Dogs / blood. Fentanyl / pharmacokinetics

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21388844.001).
  • [ISSN] 1532-2971
  • [Journal-full-title] Veterinary journal (London, England : 1997)
  • [ISO-abbreviation] Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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16. |||||||||. 98%  Fentanyl patches: preventable overdose. Prescrire Int; 2010 Feb;19(105):22-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fentanyl patches: preventable overdose.
  • Fentanyl is a potent opioid analgesic marketed for the treatment of stable intense chronic pain, particularly in the form of a transdermal patch.
  • The patches carry an added risk of fentanyl overdose because they contain very high doses, both before and after use.
  • High-risk situations for overdose were identified by examining the results of pharmacovigilance studies and medication error prevention programmes, as well as an observational study, case reports, and a French legal action.
  • The main situations exposing patients to a risk of overdose are: confusion between two dose strengths, forgetting to remove the patch; accidental transfer of the patch to another person, application of more than one patch, cutting the patches, self-medication, and ingestion.
  • Increased skin temperature facilitates fentanyl absorption and thus increases the risk of overdose; high-risk situations include fever, electric blankets, and intense physical exercise.
  • [MeSH-major] Analgesics, Opioid / administration & dosage. Analgesics, Opioid / adverse effects. Drug Overdose / prevention & control. Fentanyl / administration & dosage. Fentanyl / adverse effects
  • [MeSH-minor] Administration, Cutaneous. Chronic Disease. Humans. Pain / complications. Pain / drug therapy. Product Surveillance, Postmarketing. Skin Temperature / physiology

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  • (PMID = 20455338.001).
  • [ISSN] 1167-7422
  • [Journal-full-title] Prescrire international
  • [ISO-abbreviation] Prescrire Int
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
  • [Number-of-references] 37
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17. |||||||||. 90%  Bradley AM, Valgus JM, Bernard S: Converting to transdermal fentanyl: avoidance of underdosing. J Palliat Med; 2013 Apr;16(4):409-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Converting to transdermal fentanyl: avoidance of underdosing.
  • Specifically, variable recommendations for converting to the transdermal fentanyl patch may lead to confusion among clinicians and errors in dosing.
  • OBJECTIVE: Our aim was to describe the inconsistencies among available opioid conversions with regard to transdermal fentanyl and to provide recommendations for safe and effective utilization of this product in patients with chronic pain.
  • RESULTS: Available reports support the use of the morphine intravenous to oral ratio of 1:3 during the conversion to transdermal fentanyl product.
  • CONCLUSIONS: Underdosing is an often overlooked complication of switching to transdermal fentanyl.
  • Current recommendations for converting to transdermal fentanyl do not reflect contemporary clinical practice and should be reevaluated.
  • [MeSH-major] Anesthetics, Intravenous / administration & dosage. Dose-Response Relationship, Drug. Fentanyl / administration & dosage. Medication Errors / prevention & control. Therapeutic Equivalency

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  • (PMID = 23477303.001).
  • [ISSN] 1557-7740
  • [Journal-full-title] Journal of palliative medicine
  • [ISO-abbreviation] J Palliat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Anesthetics, Intravenous; 76I7G6D29C / Morphine; UF599785JZ / Fentanyl
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18. |||||||||. 90%  Lane ME: The transdermal delivery of fentanyl. Eur J Pharm Biopharm; 2013 Aug;84(3):449-55
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  • [Title] The transdermal delivery of fentanyl.
  • The fentanyl patch is one of the great commercial successes in transdermal drug delivery.
  • This article reviews the development of fentanyl patch technology with particular emphasis on the pharmacokinetics and disposition of the drug when delivered through the skin.
  • The influence of heat on fentanyl permeation is highlighted.
  • Post-mortem redistribution of fentanyl is discussed in light of the reported discrepancies in serum levels reported in patients after death compared with therapeutic levels in living subjects.
  • [MeSH-major] Administration, Cutaneous. Analgesics, Opioid / administration & dosage. Fentanyl / administration & dosage. Skin / drug effects

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23419814.001).
  • [ISSN] 1873-3441
  • [Journal-full-title] European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V
  • [ISO-abbreviation] Eur J Pharm Biopharm
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Analgesics; 0 / Analgesics, Opioid; 0 / Pharmaceutical Preparations; 40D3SCR4GZ / Buprenorphine; UF599785JZ / Fentanyl
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19. |||||||||. 90%  Mert T, Gunes Y, Ozcengiz D, Gunay I: Magnesium modifies fentanyl-induced local antinociception and hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol; 2009 Nov;380(5):415-20
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  • [Title] Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
  • Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies.
  • However, there is very little evidence regarding the local possible effects of fentanyl.
  • The purpose of this study was to assess whether local (intraplantar) fentanyl administration can produce antinociception and hyperalgesia.
  • In addition, we examined the effects of magnesium, N-methyl-D-aspartate receptor antagonist, on possible changes produced by fentanyl.
  • Intraplantar administration of fentanyl caused time and dose-dependent increase in the paw withdrawal latencies (antinociception).
  • Coinjection of magnesium with fentanyl markedly enhanced the antinociception.
  • However, fentanyl also markedly decreased paw withdrawal latencies 24 h after intraplantar administration (hyperalgesia).
  • In the presence of magnesium, hyperalgesia after fentanyl administration was not observed.
  • Consequently, following the fentanyl administration, local hyperalgesia after antinociception is a negative effect in pain treatment.
  • Magnesium may not only prevent the hyperalgesia but also enhance antinociceptive effect of fentanyl.
  • [MeSH-major] Analgesics, Opioid / pharmacology. Fentanyl / pharmacology. Magnesium / pharmacology. Pain / drug therapy

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  • (PMID = 19697012.001).
  • [ISSN] 1432-1912
  • [Journal-full-title] Naunyn-Schmiedeberg's archives of pharmacology
  • [ISO-abbreviation] Naunyn Schmiedebergs Arch. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Receptors, N-Methyl-D-Aspartate; I38ZP9992A / Magnesium; UF599785JZ / Fentanyl
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20. |||||||||. 90%  Dewachter P, Lefebvre D, Kalaboka S, Bloch-Morot E: An anaphylactic reaction to transdermal delivered fentanyl. Acta Anaesthesiol Scand; 2009 Sep;53(8):1092-3
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  • [Title] An anaphylactic reaction to transdermal delivered fentanyl.
  • Immediate allergic hypersensitivity reactions with fentanyl are rarely reported.
  • We diagnosed a presumably IgE-mediated allergic hypersensitivity reaction comprising generalized erythema and bronchospasm 4 h after the first-time application of transdermal fentanyl.
  • Prick test remained negative with fentanyl whereas an intradermal test (IDT) with fentanyl was positive (dilution 10(-2)).
  • The diagnosis was supported by the clinical history and a positive IDT with fentanyl.
  • [MeSH-major] Analgesics, Opioid / adverse effects. Anaphylaxis / etiology. Fentanyl / adverse effects

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  • (PMID = 19496758.001).
  • [ISSN] 1399-6576
  • [Journal-full-title] Acta anaesthesiologica Scandinavica
  • [ISO-abbreviation] Acta Anaesthesiol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Bronchodilator Agents; 37341-29-0 / Immunoglobulin E; QF8SVZ843E / Albuterol; UF599785JZ / Fentanyl
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21. |||||||||. 89%  Vucković S, Prostran M, Ivanović M, Dosen-Mićović Lj, Todorović Z, Nesić Z, Stojanović R, Divac N, Miković Z: Fentanyl analogs: structure-activity-relationship study. Curr Med Chem; 2009;16(19):2468-74
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  • [Title] Fentanyl analogs: structure-activity-relationship study.
  • Fentanyl is the prototype of the 4-anilidopiperidine class of synthetic opioid analgesics.
  • This study was aimed to review the structure-activity-relationship (SAR) of fentanyl analogs substituted in the position 3, or 4 of the piperidine ring.
  • Pharmacological results show that the groups in position 3 of the piperidine ring, which are larger than methyl, severely reduce the analgesic potency compared to fentanyl.
  • It is likely that the steric factor alone (i.e. voluminosity of the group and cis/trans isomerism), rather than the polarity and/or chemical reactivity, plays a crucial role in the analgesic potency of this series.
  • Although the duration of action, in general, does not depend on the stereochemistry, longer action of the most potent 3-alkyl fentanyl analogs such as cis-3-methyl- and cis-3-ethyl fentanyl, is more likely influenced by pharmacodynamic, rather than pharmacokinetic variables.
  • SAR findings obtained by evaluating the neurotoxic effects of fentanyl analogs substituted in the position 3 of the piperidine ring parallel the SAR findings on analgesia in regard to potency and duration of action.
  • It appears that both the potency and the duration of action in the series of fentanyl analogs substituted in position 4 of the piperidine ring is influenced only by the steric requirement and not by the chemical nature of the substituent.
  • [MeSH-major] Analgesics, Opioid / chemistry. Fentanyl / analogs & derivatives

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  • (PMID = 19601792.001).
  • [ISSN] 1875-533X
  • [Journal-full-title] Current medicinal chemistry
  • [ISO-abbreviation] Curr. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
  • [Number-of-references] 70
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22. |||||||||. 88%  Sathyan G, Phipps B, Gupta SK: Passive absorption of fentanyl from the fentanyl HCl iontophoretic transdermal system. Curr Med Res Opin; 2009 Feb;25(2):363-6
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  • [Title] Passive absorption of fentanyl from the fentanyl HCl iontophoretic transdermal system.
  • BACKGROUND: The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation.
  • OBJECTIVE: To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h period.
  • METHODS: Serial blood samples for pharmacokinetic analyses were obtained from healthy adults who received fentanyl ITS for 24 h.
  • An average total of 57.4 microg fentanyl was absorbed during the study.
  • The mean maximum observed serum fentanyl concentration was 0.06 ng/mL.
  • CONCLUSIONS: Results indicate that the average amount of fentanyl absorbed passively or via passive delivery from fentanyl ITS is minimal.
  • Maximum serum fentanyl concentrations fell below the range associated with analgesia and respiratory depression.
  • The variability in fentanyl exposure was likely exaggerated by the low amounts of drug absorption resulting in overall fairly low fentanyl concentrations.
  • [MeSH-major] Analgesics, Opioid / pharmacokinetics. Fentanyl / pharmacokinetics. Iontophoresis

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  • (PMID = 19192980.001).
  • [ISSN] 1473-4877
  • [Journal-full-title] Current medical research and opinion
  • [ISO-abbreviation] Curr Med Res Opin
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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23. |||||||||. 87%  Ahern BJ, Soma LR, Rudy JA, Uboh CE, Schaer TP: Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep. Am J Vet Res; 2010 Oct;71(10):1127-32
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  • [Title] Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep.
  • OBJECTIVE: To investigate the pharmacokinetics of fentanyl administered transdermally and IV in sheep.
  • PROCEDURES: Fentanyl was administered IV to 6 healthy sheep.
  • Transdermal fentanyl patches (TFPs) were applied to 15 sheep 12 hours prior to general anesthesia and surgery.
  • Fentanyl concentrations were quantified via liquid chromatography-mass spectrometry, and pharmacokinetic values were estimated.
  • Fentanyl concentrations were maintained at >0.5 ng/mL for 40 hours after TFP application.
  • CONCLUSIONS AND CLINICAL RELEVANCE: IV administration of fentanyl resulted in a short half-life.
  • Application of a TFP resulted in stable blood fentanyl concentrations in sheep.
  • [MeSH-major] Analgesics, Opioid / pharmacokinetics. Fentanyl / pharmacokinetics. Sheep / blood

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  • (PMID = 20919897.001).
  • [ISSN] 0002-9645
  • [Journal-full-title] American journal of veterinary research
  • [ISO-abbreviation] Am. J. Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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24. |||||||||. 87%  Garrick JF, Kidane S, Pointer JE, Sugiyama W, Van Luen C, Clark R: Analysis of the paramedic administration of fentanyl. J Opioid Manag; 2011 May-Jun;7(3):229-34
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  • [Title] Analysis of the paramedic administration of fentanyl.
  • When compared with the most commonly used morphine, fentanyl has a shorter onset of action, shorter duration, and far fewer side effects making it an appealing candidate for prehospital pain management.
  • This study's intent is to prospectively assess the feasibility and safety of fentanyl for pain in prehospital patients in comparison with morphine.
  • METHODS: Observational trial to evaluate select characteristics of fentanyl administration.
  • Secondary outcome measures included the development of adverse outcomes and side effects related to fentanyl administration.
  • RESULTS: About 16.6 percent of the patients who received fentanyl reported subjective pain relief in less than 1 minute, 47 percent in 1-2 minutes, 19.9 percent in 2-3 minutes, and 16.6 percent at greater than 3 minutes.
  • The reduction of pain after fentanyl administration, on a scale of 1-10, was 3.82 points in TOC at the ED.
  • CONCLUSIONS: Fentanyl can be used safely and effectively for pain control in the prehospital setting.
  • [MeSH-major] Allied Health Personnel. Analgesics, Opioid / therapeutic use. Emergency Medical Services. Fentanyl / therapeutic use. Pain / drug therapy

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  • (PMID = 21823553.001).
  • [ISSN] 1551-7489
  • [Journal-full-title] Journal of opioid management
  • [ISO-abbreviation] J Opioid Manag
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 76I7G6D29C / Morphine; UF599785JZ / Fentanyl
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25. |||||||||. 87%  Schmidt B, Adelmann C, Stützer H, Welzing L, Hünseler C, Kribs A, Roth B: Comparison of sufentanil versus fentanyl in ventilated term neonates. Klin Padiatr; 2010 Mar;222(2):62-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of sufentanil versus fentanyl in ventilated term neonates.
  • METHODS: In a double-blind randomized trial 20 newborns received a continuous intravenous infusion of fentanyl (n=10) or sufentanil (n=10) in an assumed equipotent dose of 7:1.
  • The period between cessation of analgesic medication and successful extubation (weaning time), adverse drug effects and urinary cortisol concentrations were evaluated.
  • RESULTS: No significant difference of weaning time was seen between fentanyl and sufentanil group (mean weaning time (+/-SD) of fentanyl group 520+/-381 min, median 380 min; sufentanil group 585+/-531 min, median 405 min, p=0.78, 2-tailed U-Test, Mann and Whitney).
  • The mean opioid dose resulted in a 10:1 ratio (fentanyl 4.11 microg/(kg x h) vs sufentanil 0.41 microg/(kg x h)).
  • We found no marked differences in sedation levels, blood pressure, heart rate, oxygenation index, co-medication or urinary cortisol levels.
  • CONCLUSION: In our study sufentanil did not reduce the weaning period in ventilated term neonates when compared to fentanyl.
  • The equipotent dose ratio for fentanyl/sufentanil was 10:1.
  • [MeSH-major] Anesthesia, Intravenous. Anesthetics, Intravenous. Fentanyl. Intermittent Positive-Pressure Ventilation. Respiratory Distress Syndrome, Newborn / therapy. Sufentanil

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  • [Copyright] (c) Georg Thieme Verlag KG Stuttgart-New York.
  • (PMID = 19731193.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; AFE2YW0IIZ / Sufentanil; UF599785JZ / Fentanyl
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26. |||||||||. 87%  Lim BG, Lee JY, Kim H, Lee DK, Lee MK: Nystagmus caused by epidural fentanyl. J Anesth; 2012 Feb;26(1):94-6
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  • [Title] Nystagmus caused by epidural fentanyl.
  • We recently experienced a case in which a 73-year-old woman presented predominantly vertical nystagmus as a neurological complication after epidural administration of fentanyl.
  • A few previous reports on opioids as causative agents for nystagmus have all after use of epidural morphine, and there are yet no publications reporting epidural fentanyl as the cause of nystagmus.
  • Physicians should keep in mind that epidural fentanyl could cause the nystagmus as a neurological complication even though it is used within conventional dosage ranges, although this is very rare.
  • Also, when a patient develops nystagmus after epidural fentanyl, it could be a benign side effect caused by epidural fentanyl as we have experienced, but it could also be a sign of serious central nervous system lesions especially in patients with underlying risk factors such as old age, diabetes mellitus, hypertension, and cerebrovascular disease, and thus special attention should be paid to this.
  • [MeSH-major] Analgesia, Epidural / adverse effects. Analgesics, Opioid / adverse effects. Fentanyl / adverse effects. Nystagmus, Pathologic / chemically induced

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  • (PMID = 22038616.001).
  • [ISSN] 1438-8359
  • [Journal-full-title] Journal of anesthesia
  • [ISO-abbreviation] J Anesth
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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27. |||||||||. 87%  Garbe E, Jobski K, Schmid U: Utilisation of transdermal fentanyl in Germany from 2004 to 2006. Pharmacoepidemiol Drug Saf; 2012 Feb;21(2):191-8
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  • [Title] Utilisation of transdermal fentanyl in Germany from 2004 to 2006.
  • Transdermal fentanyl is an alternative in patients with stable requirements of high-potency opioids (HPO) or if drugs cannot be taken orally.
  • Drug regulatory authorities have issued several alerts to use transdermal fentanyl only for chronic pain and in HPO-tolerant patients to minimise the risk of severe opioid side effects.
  • The aim of this study was to characterise utilisation of transdermal fentanyl in Germany.
  • Descriptive analyses were performed in new users of transdermal fentanyl to assess HPO-naïvety, potential difficulties with the oral route in HPO-naïve patients and the number of transdermal fentanyl dispensations.
  • The initial dose in new users was assessed in 2005-2006 after marketing of transdermal fentanyl 12.5 µg/hour.
  • RESULTS: Of 35 262 patients with new use of transdermal fentanyl, 29 793 (84.5%) were assessed as HPO-naïve.
  • For 71.2% of the HPO-naïve new users of transdermal fentanyl, the first dose exceeded the recommended dose of 12.5 µg/hour, and 49.3% of them received only one prescription of the drug.
  • CONCLUSIONS: Transdermal fentanyl was used as a first-choice opioid, which may increase the risk of serious opioid side effects, in a substantial number of HPO-naïve patients.
  • [MeSH-major] Analgesics, Opioid / therapeutic use. Fentanyl / therapeutic use. Pain / drug therapy

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  • [Copyright] Copyright © 2011 John Wiley & Sons, Ltd.
  • [CommentIn] Pharmacoepidemiol Drug Saf. 2012 Aug;21(8):902-3 [22836720.001]
  • (PMID = 21681850.001).
  • [ISSN] 1099-1557
  • [Journal-full-title] Pharmacoepidemiology and drug safety
  • [ISO-abbreviation] Pharmacoepidemiol Drug Saf
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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28. |||||||||. 87%  Lin BF, Ju DT, Cherng CH, Hung NK, Yeh CC, Chan SM, Wu CT: Comparison between intraoperative fentanyl and tramadol to improve quality of emergence. J Neurosurg Anesthesiol; 2012 Apr;24(2):127-32
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  • [Title] Comparison between intraoperative fentanyl and tramadol to improve quality of emergence.
  • We compared fentanyl and an antitussive action of tramadol on the quality of emergence and postoperative outcome.
  • The patients assigned to the fentanyl group received a dose of 1 μg/kg of fentanyl, whereas those assigned to the tramadol group received 1 mg/kg of tramadol, at the beginning of skin closure.
  • We recorded the incidence of cough, quality of extubation at fixed times, maximal heart rates, maximal blood pressure during emergence, postoperative pain scores, and consumption of fentanyl.
  • There was no significant difference in postoperative pain, fentanyl consumption, incidence and severity of POST, hoarseness, and postoperative nausea and vomiting between groups.
  • CONCLUSIONS: A dose of 1 mg/kg of tramadol administered intravenously 30 minutes before the expected extubation, compared with 1 μg/kg of fentanyl, decreased cough incidence, improved emergence quality, and provided stable hemodynamics.
  • However, there was no significant difference between tramadol and fentanyl in pain scores and fentanyl consumption postoperatively.
  • [MeSH-major] Analgesics, Opioid / pharmacology. Anesthesia Recovery Period. Fentanyl / pharmacology. Narcotics / pharmacology. Postoperative Complications / prevention & control. Tramadol / pharmacology

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  • (PMID = 22089326.001).
  • [ISSN] 1537-1921
  • [Journal-full-title] Journal of neurosurgical anesthesiology
  • [ISO-abbreviation] J Neurosurg Anesthesiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Narcotics; 39J1LGJ30J / Tramadol; UF599785JZ / Fentanyl
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29. |||||||||. 87%  Lötsch J, Walter C, Parnham MJ, Oertel BG, Geisslinger G: Pharmacokinetics of non-intravenous formulations of fentanyl. Clin Pharmacokinet; 2013 Jan;52(1):23-36
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  • [Title] Pharmacokinetics of non-intravenous formulations of fentanyl.
  • Fentanyl was structurally designed by Paul Janssen in the early 1960s as a potent opioid analgesic (100-fold more potent than morphine).
  • Non-intravenous preparations deliver fentanyl orally-transmucosally, intranasally or transdermally.
  • Passive transdermal patches release fentanyl at a constant zero-order rate for 2-3 days, making them suitable for chronic pain management, as are iontophoretic transdermal systems.
  • Oral transmucosal and intranasal routes provide fast delivery (time to reach maximum fentanyl plasma concentrations 20 min [range 20-180 min] and 12 min [range 12-21 min], respectively) suitable for rapid onset of analgesia in acute pain conditions with time to onset of analgesia of 5 or 2 min, respectively.
  • Thanks to the development of non-intravenous pharmaceutical formulations, fentanyl has become one of the most successful opioid analgesics, and can be regarded as an example of a successful reformulation strategy of an existing drug based on pharmacokinetic research and pharmaceutical technology.
  • This development broadened the indications for fentanyl beyond the initial restriction to intra- or perioperative clinical uses.
  • The clinical utility of fentanyl could be expanded further by more comprehensive mathematical characterizations of its parametric pharmacokinetic input functions as a basis for the rational selection of fentanyl formulations for individualized pain therapy.
  • [MeSH-major] Analgesics, Opioid / pharmacokinetics. Fentanyl / pharmacokinetics

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  • [CommentIn] Clin Pharmacokinet. 2013 May;52(5):397-8 [23553424.001]
  • (PMID = 23100195.001).
  • [ISSN] 0312-5963
  • [Journal-full-title] Clinical pharmacokinetics
  • [ISO-abbreviation] Clin Pharmacokinet
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Receptors, Opioid; EC 1.14.14.1 / Cytochrome P-450 CYP3A; UF599785JZ / Fentanyl
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30. |||||||||. 87%  Aldington D, Jagdish S: The fentanyl 'lozenge' story: from books to battlefield. J R Army Med Corps; 2014 Jun;160(2):102-4
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  • [Title] The fentanyl 'lozenge' story: from books to battlefield.
  • This article outlines the process that led to the introduction of the fentanyl lozenge for acute pain management.
  • There follows a description of the pharmacology of fentanyl before describing the trial of concept that was conducted.
  • [MeSH-major] Analgesics, Opioid. Fentanyl. Military Medicine. Pain Management / history. Pain Management / methods

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  • [Copyright] Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
  • (PMID = 24413475.001).
  • [ISSN] 0035-8665
  • [Journal-full-title] Journal of the Royal Army Medical Corps
  • [ISO-abbreviation] J R Army Med Corps
  • [Language] eng
  • [Publication-type] Editorial; Historical Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
  • [Keywords] NOTNLM ; Accident & Emergency Medicine / Pain Management
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31. |||||||||. 87%  Iizuka T, Kamata M, Yanagawa M, Nishimura R: Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs. Vet J; 2013 Oct;198(1):289-91
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  • [Title] Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs.
  • This study aimed to compare the incidence of IOH in anaesthetised dogs when isoflurane-fentanyl was used, compared to propofol-fentanyl.
  • The incidence of IOH was 65.3% for isoflurane-fentanyl and 27.6% for propofol-fentanyl.
  • The adjusted odds ratio for IOH when propofol-fentanyl was compared to isoflurane-fentanyl was 0.2 (95% CI 0.11-0.38).
  • These results suggest that propofol-fentanyl is associated with a lower risk of IOH than isoflurane-fentanyl anaesthesia.
  • [MeSH-minor] Animals. Dogs. Female. Fentanyl / adverse effects. Incidence. Isoflurane / adverse effects. Male. Propofol / adverse effects. Tokyo / epidemiology

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 23938002.001).
  • [ISSN] 1532-2971
  • [Journal-full-title] Veterinary journal (London, England : 1997)
  • [ISO-abbreviation] Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Anesthetics, Inhalation; 0 / Anesthetics, Intravenous; CYS9AKD70P / Isoflurane; UF599785JZ / Fentanyl; YI7VU623SF / Propofol
  • [Keywords] NOTNLM ; Dogs / Fentanyl / Intraoperative hypotension / Isoflurane / Propofol
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32. |||||||||. 86%  Coruh B, Tonelli MR, Park DR: Fentanyl-induced chest wall rigidity. Chest; 2013 Apr;143(4):1145-6
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  • [Title] Fentanyl-induced chest wall rigidity.
  • Fentanyl and other opiates used in procedural sedation and analgesia are associated with several well-known complications.
  • We report the case of a man who developed the uncommon complication of chest wall rigidity and ineffective spontaneous ventilation following the administration of fentanyl during an elective bronchoscopy.
  • Although this complication is better described in pediatric patients and with anesthetic doses, chest wall rigidity can occur with analgesic doses of fentanyl and related compounds.
  • This reaction does not appear to be a contraindication to future use of fentanyl or related compounds.
  • [MeSH-major] Analgesics, Opioid / adverse effects. Bronchoscopy / adverse effects. Fentanyl / adverse effects. Muscle Rigidity / chemically induced. Thoracic Wall / physiopathology

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  • [CommentIn] Chest. 2013 Sep;144(3):1083-4 [24008969.001]
  • [CommentIn] Chest. 2013 Sep;144(3):1083 [24008968.001]
  • (PMID = 23546488.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Narcotic Antagonists; 36B82AMQ7N / Naloxone; UF599785JZ / Fentanyl
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33. |||||||||. 86%  Hung KC, Chen CW, Lin VC, Weng HC, Hsieh SW: The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing. Anaesthesia; 2010 Jan;65(1):4-7
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  • [Title] The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing.
  • We performed a randomised, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous fentanyl (25 microg) on the incidence of cough caused by a larger bolus of intravenous fentanyl.
  • Six hundred patients were randomly assigned to one of three groups to receive either 0.5 ml saline 0.9% 1 min before administration of fentanyl 150 microg (3 ml), or pre-emptive fentanyl 25 microg (0.5 ml) 1 min before administration of fentanyl 125 microg or 150 microg.
  • The incidence of fentanyl-induced cough was significantly lower in both pre-emptive groups (7 (3.5%) for 125 microgfentanyl and 15 (7.5%) for 150 microg fentanyl) than in the saline group (37 (18.5%); p = 0.001).
  • We conclude that pre-emptive use of fentanyl 25 microg, administered 1 min before bolus injection of fentanyl (125 or 150 microg), can effectively suppress fentanyl-induced cough.
  • [MeSH-major] Anesthetics, Intravenous / administration & dosage. Cough / prevention & control. Fentanyl / administration & dosage. Intraoperative Complications / prevention & control

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  • [CommentIn] Anaesthesia. 2010 May;65(5):536-7 [20522043.001]
  • (PMID = 19889113.001).
  • [ISSN] 1365-2044
  • [Journal-full-title] Anaesthesia
  • [ISO-abbreviation] Anaesthesia
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; UF599785JZ / Fentanyl
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34. |||||||||. 85%  Jumbelic MI: Deaths with transdermal fentanyl patches. Am J Forensic Med Pathol; 2010 Mar;31(1):18-21
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  • [Title] Deaths with transdermal fentanyl patches.
  • Fentanyl is a potent Schedule II narcotic analgesic recommended for use in the management of unremitting pain not controlled by morphine or other opiate/opioid drugs.
  • The danger inherent to fentanyl is its potency (greater than 50-100 times that of morphine) and rapidity of action, causing respiratory depression within minutes of administration.
  • In the year 2006, the Center for Forensic Sciences in Onondaga County had 8 cases where fentanyl was considered the cause of death, often with other drugs detected in therapeutic concentrations.
  • All of these 2006 overdoses because of fentanyl involved the transdermal formulation.
  • The investigative data, blood and liver fentanyl levels, and autopsy findings will be presented.
  • [MeSH-major] Analgesics, Opioid / poisoning. Fentanyl / poisoning
  • [MeSH-minor] Administration, Cutaneous. Adolescent. Adult. Body Mass Index. Drug Overdose. Drug Prescriptions. Female. Forensic Toxicology. Humans. Liver / chemistry. Male. Middle Aged. Substance-Related Disorders / complications

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  • (PMID = 19918162.001).
  • [ISSN] 1533-404X
  • [Journal-full-title] The American journal of forensic medicine and pathology
  • [ISO-abbreviation] Am J Forensic Med Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; UF599785JZ / Fentanyl
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35. |||||||||. 85%  Juś A, Bujalska M, Makulska-Nowak HE: Modification of fentanyl analgesia by antidepressants. Pharmacology; 2010;85(1):48-53
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  • [Title] Modification of fentanyl analgesia by antidepressants.
  • The purpose of this paper was to verify how the analgesic action of fentanyl (0.05 mg/kg) is affected by single administration as well as 4- or 21-day premedication with antidepressants characterized by various mechanisms of action.
  • It was concluded that the single administration of an antidepressant increases the analgesic action of fentanyl.
  • Four-day premedication with fluoxetine and reboxetine significantly attenuated the antinociceptive action of fentanyl, whereas 21-day premedication with all antidepressants investigated (fluoxetine, amitriptyline, moclobemide, reboxetine) markedly decreased it.
  • [MeSH-major] Analgesics, Opioid / pharmacology. Antidepressive Agents / pharmacology. Fentanyl / pharmacology. Pain / drug therapy

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 20029244.001).
  • [ISSN] 1423-0313
  • [Journal-full-title] Pharmacology
  • [ISO-abbreviation] Pharmacology
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Antidepressive Agents; UF599785JZ / Fentanyl
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36. |||||||||. 85%  Wang SY, Mei Y, Sheng H, Li Y, Han R, Quan CX, Hu ZH, Ouyang W, Liu ZQ, Duan KM: Tramadol combined with fentanyl in awake endotracheal intubation. J Thorac Dis; 2013 Jun;5(3):270-7
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  • [Title] Tramadol combined with fentanyl in awake endotracheal intubation.
  • OBJECTIVE: To explore the feasibility and dosage of tramadol combined with fentanyl in awake endotracheal intubation.
  • The feasibility and dosage of tramadol combined with fentanyl in awake endotracheal intubation, guided by fiberoptic bronchoscopy, were verified.
  • RESULTS: After intravenous injection with fentanyl 2.2 μg/kg and tramadol 2.0 mg/kg in the 20-49 age group, fentanyl 1.6 μg/kg and tramadol 1.9 mg/kg in the 50-69 age group and fentanyl 1 μg/kg and tramadol 1.8 mg/kg in those at the age of 70 or above, the patients achieved conscious sedation without obvious respiratory depression.
  • CONCLUSIONS: Fiberoptic bronchoscope guided nasotracheal intubation can be successfully completed with background administration of fentanyl and tramadol.

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  • (PMID = 23825758.001).
  • [ISSN] 2072-1439
  • [Journal-full-title] Journal of thoracic disease
  • [ISO-abbreviation] J Thorac Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3698251
  • [Keywords] NOTNLM ; Awake endotracheal intubation / fentanyl / fiberoptic bronchoscope / nasotracheal intubation / tramadol
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37. ||||||||.. 85%  In brief: heat and transdermal fentanyl. Med Lett Drugs Ther; 2009 Aug 10;51(1318):64
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  • [Title] In brief: heat and transdermal fentanyl.
  • Transdermal fentanyl (Duragesic, and others) offers a convenient delivery system for patients with chronic pain but it has some drawbacks.
  • [MeSH-major] Analgesics, Opioid / administration & dosage. Fentanyl / administration & dosage

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  • (PMID = 19661852.001).
  • [ISSN] 1523-2859
  • [Journal-full-title] The Medical letter on drugs and therapeutics
  • [ISO-abbreviation] Med Lett Drugs Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Delayed-Action Preparations; 0 / Narcotic Antagonists; UF599785JZ / Fentanyl
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38. ||||||||.. 84%  Turkmen A, Moralar DG, Ali A, Altan A: Comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl and bupivacaine + fentanyl during caesarean section. Middle East J Anesthesiol; 2012 Feb;21(4):577-82
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  • [Title] Comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl and bupivacaine + fentanyl during caesarean section.
  • The aim of the present study was to compare the anesthetic effects of levobupivacaine + fentanyl and bupivacaine + fentanyl on the mother and newborn during elective caesarean section under spinal anesthesia.
  • The patients were randomized into one of the following two groups: bupivacaine + fentanyl group (group B; n = 25), 7.5 mg of 0.5% bupivacaine + 15 microg fentanyl intrathecally; levobupivacaine + fentanyl group (group L; n = 25), 7.5 mg of 0.5% levobupivacaine + 15 microg fentanyl intrathecally.
  • CONCLUSIONS: Time to sensory and maximum motor block was shorter in the bupivacaine + fentanyl group.
  • On the other hand, a longer duration of analgesia was achieved in the levobupivacaine + fentanyl group.
  • [MeSH-major] Anesthesia, Obstetrical / methods. Cesarean Section / methods. Fentanyl / administration & dosage

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  • (PMID = 23327030.001).
  • [ISSN] 0544-0440
  • [Journal-full-title] Middle East journal of anesthesiology
  • [ISO-abbreviation] Middle East J Anesthesiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Lebanon
  • [Chemical-registry-number] 0 / Anesthetics, Intravenous; 0 / Anesthetics, Local; A5H73K9U3W / levobupivacaine; UF599785JZ / Fentanyl; Y8335394RO / Bupivacaine
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39. ||||||||.. 83%  Lesage S, Drolet P, Donati F, Racine S, Fortier LP, Audy D: Low-dose fentanyl-midazolam combination improves sevoflurane induction in adults. Can J Anaesth; 2009 Oct;56(10):733-9
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  • [Title] Low-dose fentanyl-midazolam combination improves sevoflurane induction in adults.
  • PURPOSE: We investigated the effects of a combination of low-dose fentanyl-midazolam premedication on the speed of inhaled induction with sevoflurane and ProSeal laryngeal mask airway (PLMA) insertion conditions.
  • METHODS: Eighty adult patients undergoing elective surgery were randomized in a double-blind fashion to receive either a normal saline placebo (Group PLAC) or a fentanyl 0.6 microg x kg(-1) and midazolam 9 microg x kg(-1) premedication (Group FM) 5 min before tidal volume sevoflurane 8%/O(2) induction.
  • CONCLUSION: Administration of a low-dose fentanyl-midazolam combination prior to sevoflurane induction decreases time to LER and allows for more rapid and less eventful PLMA insertion.
  • [MeSH-major] Anesthesia, General. Anesthetics, Inhalation. Anesthetics, Intravenous. Fentanyl. Methyl Ethers. Midazolam. Preanesthetic Medication

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  • (PMID = 19641980.001).
  • [ISSN] 1496-8975
  • [Journal-full-title] Canadian journal of anaesthesia = Journal canadien d'anesthésie
  • [ISO-abbreviation] Can J Anaesth
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00723164
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; 0 / Anesthetics, Intravenous; 0 / Methyl Ethers; 28523-86-6 / sevoflurane; R60L0SM5BC / Midazolam; UF599785JZ / Fentanyl
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40. ||||||||.. 83%  Hirsh I, Lerner A, Shnaider I, Reuveni A, Pacht A, Segol O, Pizov R: Remifentanil versus fentanyl for esophagogastroduodenoscopy in children. J Pediatr Gastroenterol Nutr; 2010 Nov;51(5):618-21
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  • [Title] Remifentanil versus fentanyl for esophagogastroduodenoscopy in children.
  • OBJECTIVES: We compared sedation by propofol combined with either fentanyl or remifentanil in pediatric outpatients undergoing diagnostic esophagogastroduodenoscopy.
  • PATIENTS AND METHODS: Forty-two children scheduled for esophagogastroduodenoscopy in our institution were randomly assigned to receive 2 mg/kg propofol plus either 1 μg/kg bolus of fentanyl (group F; n = 20) or 0.5 μg/kg bolus of remifentanil (group R; n = 22).
  • CONCLUSIONS: Remifentanil in combination with propofol provides good analgesic and sedative effects, which were shorter lasting compared with fentanyl-based sedation, and caused fewer delayed adverse effects.
  • [MeSH-major] Analgesics, Opioid / therapeutic use. Endoscopy, Digestive System / adverse effects. Fentanyl / therapeutic use. Hypnotics and Sedatives. Piperidines / therapeutic use. Propofol

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  • (PMID = 20808251.001).
  • [ISSN] 1536-4801
  • [Journal-full-title] Journal of pediatric gastroenterology and nutrition
  • [ISO-abbreviation] J. Pediatr. Gastroenterol. Nutr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Hypnotics and Sedatives; 0 / Piperidines; P10582JYYK / remifentanil; UF599785JZ / Fentanyl; YI7VU623SF / Propofol
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41. ||||||||.. 82%  Pypendop BH, Brosnan RJ, Majewski-Tiedeken CR, Stanley SD, Ilkiw JE: Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. J Vet Pharmacol Ther; 2014 Feb;37(1):13-7
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  • [Title] Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats.
  • The aim of this study was to compare the pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats.
  • Fentanyl (10 μg/kg), alfentanil (100 μg/kg), or sufentanil (1 μg/kg) was administered intravenously as a bolus, on separate days.
  • The volume of the central compartment and the volume of distribution at steady-state (L/kg) [mean ± SEM (range)], the clearance (mL/min/kg) [harmonic mean ± pseudo-SD (range)], and the terminal half-life (min) [median (range)] were 0.25 ± 0.04 (0.09-0.34), 2.18 ± 0.16 (1.79-2.83), 18.6 ± 5.0 (15-29.8), and 151 (115-211) for fentanyl; 0.10 ± 0.01 (0.07-0.14), 0.89 ± 0.16 (0.68-1.83), 11.6 ± 2.6 (9.2-15.8), and 144 (118-501) for alfentanil; and 0.06 ± 0.01 (0.04-0.10), 0.77 ± 0.07 (0.63-0.99), 17.6 ± 4.3 (13.9-24.3), and 54 (46-76) for sufentanil.
  • Differences in clearance and volume of distribution result in similar terminal half-lives for fentanyl and alfentanil, longer than for sufentanil.

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  • [Copyright] © 2013 John Wiley & Sons Ltd.
  • (PMID = 23895731.001).
  • [ISSN] 1365-2885
  • [Journal-full-title] Journal of veterinary pharmacology and therapeutics
  • [ISO-abbreviation] J. Vet. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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42. ||||||||.. 82%  Mustola S, Parkkari T, Uutela K, Huiku M, Kymäläinen M, Toivonen J: Performance of Surgical Stress Index during Sevoflurane-Fentanyl and Isoflurane-Fentanyl Anesthesia. Anesthesiol Res Pract; 2010;2010
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  • [Title] Performance of Surgical Stress Index during Sevoflurane-Fentanyl and Isoflurane-Fentanyl Anesthesia.
  • The performance of recently introduced Surgical Stress Index (SSI), based on heart rate and photoplethysmography, was estimated during sevoflurane-fentanyl and isoflurane-fentanyl anesthesia during surgical procedures.
  • Anesthesia was induced with fentanyl 2 mug kg(-1) and thiopentone 3-5 mg kg(-1).
  • Tracheal intubation was performed 5 minutes after fentanyl bolus.
  • During surgery, fentanyl boluses 1.5 mug kg(-1) were given at 30-40-minute intervals.
  • During surgery, the decrease of SSI after fentanyl boluses was similar in sevoflurane and isoflurane groups but SSI values were higher in sevoflurane than in isoflurane group.
  • Fentanyl boluses during surgery decreased SSI, indicating that increasing analgesia decreases SSI.

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  • [Cites] Acta Cardiol. 2005 Oct;60(5):459-64 [16261774.001]
  • [Cites] Br J Anaesth. 2006 May;96(5):620-6 [16531443.001]
  • [Cites] Br J Anaesth. 2007 Apr;98(4):447-55 [17329347.001]
  • [Cites] Anesthesiology. 2004 Jun;100(6):1353-72 [15166553.001]
  • (PMID = 20700429.001).
  • [ISSN] 1687-6970
  • [Journal-full-title] Anesthesiology research and practice
  • [ISO-abbreviation] Anesthesiol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2911596
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43. ||||||||.. 81%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Butorphanol Fentanyl': Top Publications. BioMedLib Review; OrganicChemical;ButorphanolFentanyl:705705685. ISSN: 2331-5717. 2014/4/26
PDF icon [Fulltext service] Download fulltext PDF of this article.

  • [Title] 'Organic Chemicals' associated with 'Butorphanol Fentanyl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'organic chemical' for 'butorphanol fentanyl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'organic chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 111 publications.
  • Here are the top 10.
  • Arora V et al: Comparative evaluation of recovery characteristics of fentanyl and butorphanol when used as supplement to propofol anaesthesia.
  • Kaur J et al: Dose sparing of induction dose of propofol by fentanyl and butorphanol: A comparison based on entropy analysis.
  • Gupta A et al: Comparative evaluation of ketamine - propofol, fentanyl - propofol and butorphanol-propofol on haemodynamics and laryngeal mask airway insertion conditions.
  • Pandit SK et al: Comparison of fentanyl and butorphanol for outpatient anaesthesia.
  • Ambrisko TD et al: Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl, and ketamine administration in dogs.
  • Chen JC et al: The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine.
  • Dryden GE: Voluntary respiratory effects of butorphanol and fentanyl following barbiturate induction: a double-blind study.
  • Day OL 2nd et al: Outpatient sedation for oral surgery: a comparison of butorphanol and fentanyl.
  • Rath GP et al: Effects of butorphanol and fentanyl on cerebral pressures and cardiovascular hemodynamics during tunneling phase for ventriculoperitoneal shunt insertion.
  • McCammon RL et al: Effects of butorphanol, nalbuphine, and fentanyl on intrabiliary tract dynamics.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705705685.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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44. ||||||||.. 81%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Fentanyl Nalbuphine': Top Publications. BioMedLib Review; OrganicChemical;FentanylNalbuphine:705705666. ISSN: 2331-5717. 2014/4/26
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  • [Title] 'Organic Chemicals' associated with 'Fentanyl Nalbuphine': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'organic chemical' for 'fentanyl nalbuphine'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'organic chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 38 publications, and group two 149 publications.
  • Here are the top 10.
  • Lefèvre B et al: Comparison of nalbuphine and fentanyl as intravenous analgesics for medically compromised patients undergoing oral surgery.
  • Tabatabai M et al: Disruption of the rhythmic activity of the medullary inspiratory neurons and phrenic nerve by fentanyl and reversal with nalbuphine.
  • Jaffe RS et al: Nalbuphine antagonism of fentanyl-induced ventilatory depression: a randomized trial.
  • van den Berg AA et al: Analgesics and ENT surgery. A clinical comparison of the intraoperative, recovery and postoperative effects of buprenorphine, diclofenac, fentanyl, morphine, nalbuphine, pethidine and placebo given intravenously with induction of anaesthesia.
  • DesMarteau JK et al: Acute pulmonary edema resulting from nalbuphine reversal of fentanyl-induced respiratory depression.
  • Moldenhauer CC et al: Nalbuphine antagonism of ventilatory depression following high-dose fentanyl anesthesia.
  • Davies GG et al: A blinded study using nalbuphine for prevention of pruritus induced by epidural fentanyl.
  • Dick W et al: [Histamine release during induction of combination anesthesia using nalbuphine or fentanyl. Modulation of the reaction by premedication with promethazine/pethidine].
  • Khan FA et al: Comparison of fentanyl and nalbuphine in total intravenous anaesthesia (TIVA).
  • Rawal N et al: Influence of perioperative nalbuphine and fentanyl on postoperative respiration and analgesia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705705666.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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45. ||||||||.. 81%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Buprenorphine Fentanyl': Top Publications. BioMedLib Review; OrganicChemical;BuprenorphineFentanyl:705703569. ISSN: 2331-5717. 2014/4/26
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  • [Title] 'Organic Chemicals' associated with 'Buprenorphine Fentanyl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'organic chemical' for 'buprenorphine fentanyl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'organic chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 38 publications, and group two 230 publications.
  • Here are the top 10.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics.
  • Dahan A et al: Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats.
  • Yassen A et al: Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats.
  • Anaraki AN et al: Effect of fentanyl versus buprenorphine on the pupil size in phacoemulsification cataract surgery.
  • Cichewicz DL et al: Enhancement of transdermal fentanyl and buprenorphine antinociception by transdermal delta9-tetrahydrocannabinol.
  • Berg T et al: Determination of buprenorphine, fentanyl and LSD in whole blood by UPLC-MS-MS.
  • Koltzenburg M et al: Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine.
  • Zuurmond WW et al: Partial versus full agonists for opioid-mediated analgesia--focus on fentanyl and buprenorphine.
  • Andresen T et al: Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705703569.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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46. ||||||||.. 81%  Cooper IF, Siadaty MS: 'Organism Functions' associated with 'Fentanyl Ropivacaine': Top Publications. BioMedLib Review; OrganismFunction;FentanylRopivacaine:706024883. ISSN: 2331-5717. 2014/12/20
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  • [Title] 'Organism Functions' associated with 'Fentanyl Ropivacaine': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organism Function' for 'fentanyl ropivacaine'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organism Function'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 16 publications, and group two 344 publications.
  • Here are the top 9.
  • Fettes PD et al: Intermittent vs continuous administration of epidural ropivacaine with fentanyl for analgesia during labour.
  • Hughes D et al: Intrathecal ropivacaine or bupivacaine with fentanyl for labour.
  • Dresner M et al: Ropivacaine 0.2% versus bupivacaine 0.1% with fentanyl: a double blind comparison for analgesia during labour.
  • Desai S et al: Chronobiology of parturients receiving neuraxial labour analgesia with ropivacaine and fentanyl: a prospective cohort study.
  • Tveit TO et al: Labour analgesia: a randomised, controlled trial comparing intravenous remifentanil and epidural analgesia with ropivacaine and fentanyl.
  • Ruban P et al: The effect of adding fentanyl to ropivacaine 0.125% on patient-controlled epidural analgesia during labour.
  • Finegold H et al: Comparison of ropivacaine 0.1%-fentanyl and bupivacaine 0.125%-- fentanyl infusions for epidural labour analgesia.
  • Atienzar MC et al: Ropivacaine 0.1% with fentanyl 2 microg mL(-1) by epidural infusion for labour analgesia.
  • Purdie NL et al: Comparison of patient-controlled epidural bolus administration of 0.1% ropivacaine and 0.1% levobupivacaine, both with 0.0002% fentanyl, for analgesia during labour.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706024883.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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47. ||||||||.. 80%  Cooper IF, Siadaty MS: 'Spatial Concepts' associated with 'Fentanyl Ropivacaine': Top Publications. BioMedLib Review; SpatialConcept;FentanylRopivacaine:706025635. ISSN: 2331-5717. 2014/10/20
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  • [Title] 'Spatial Concepts' associated with 'Fentanyl Ropivacaine': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Spatial Concept' for 'fentanyl ropivacaine'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Spatial Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 499 publications.
  • Here are the top 10.
  • Hong JY et al: Effects of epidural fentanyl on speed and quality of block for emergency cesarean section in extending continuous epidural labor analgesia using ropivacaine and fentanyl.
  • Manuar MB et al: Pain relief after Arthroscopic Knee Surgery: A comparison of intra-articular ropivacaine, fentanyl, and dexmedetomidine: A prospective, double-blinded, randomized controlled study.
  • Chaudhary A et al: Efficacy of spinal ropivacaine versus ropivacaine with fentanyl in transurethral resection operations.
  • Mohta M et al: Continuous paravertebral infusion of ropivacaine with or without fentanyl for pain relief in unilateral multiple fractured ribs.
  • Rastogi B et al: Hemiarthroplasty in high risk elderly patient under epidural anesthesia with 0.75% ropivacaine-fentanyl versus 0.5% bupivacaine-fentanyl: Clinical trial.
  • Lee JH et al: A comparison of epidural infusion of 0.2, 0.25, and 0.3% ropivacaine with fentanyl after unilateral total knee arthroplasty.
  • Panni MK et al: Minimum effective dose of spinal ropivacaine with and without fentanyl for postpartum tubal ligation.
  • Steinberg RB et al: Comparison of ropivacaine-fentanyl patient-controlled epidural analgesia with morphine intravenous patient-controlled analgesia for perioperative analgesia and recovery after open colon surgery.
  • Kallio H et al: Spinal hyperbaric ropivacaine-fentanyl for day-surgery.
  • Amano E et al: [Study of analgestic efficacy of ropivacaine-fentanyl patient-controlled epidural analgesia after upper abdominal gynecological surgery].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706025635.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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48. ||||||||.. 80%  Yu C, Li S, Deng F, Yao Y, Qian L: Comparison of dexmedetomidine/fentanyl with midazolam/fentanyl combination for sedation and analgesia during tooth extraction. Int J Oral Maxillofac Surg; 2014 Sep;43(9):1148-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of dexmedetomidine/fentanyl with midazolam/fentanyl combination for sedation and analgesia during tooth extraction.
  • This study investigated whether combined dexmedetomidine/fentanyl offered better sedation and analgesia than midazolam/fentanyl in dental surgery.
  • Sixty patients scheduled for unilateral impacted tooth extraction were randomly assigned to receive either dexmedetomidine and fentanyl (D/F) or midazolam and fentanyl (M/F).
  • Therefore, dexmedetomidine/fentanyl appears to provide better sedation, stable haemodynamics, surgeon satisfaction, and postoperative analgesia than midazolam/fentanyl during office-based unilateral impacted tooth extraction.

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  • [Copyright] Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 24794760.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Keywords] NOTNLM ; analgesia / day surgery / dental surgery / dexmedetomidine / fentanyl / midazolam
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49. ||||||||.. 80%  Cooper IF, Siadaty MS: 'Steroids' associated with 'Buprenorphine Fentanyl': Top Publications. BioMedLib Review; Steroid;BuprenorphineFentanyl:705904819. ISSN: 2331-5717. 2014/5/3
PDF icon [Fulltext service] Download fulltext PDF of this article.

  • [Title] 'Steroids' associated with 'Buprenorphine Fentanyl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'steroid' for 'buprenorphine fentanyl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'steroid'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 312 publications.
  • Here are the top 10.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics.
  • Dahan A et al: Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats.
  • Yassen A et al: Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats.
  • van den Berg AA et al: Analgesics and ENT surgery. A clinical comparison of the intraoperative, recovery and postoperative effects of buprenorphine, diclofenac, fentanyl, morphine, nalbuphine, pethidine and placebo given intravenously with induction of anaesthesia.
  • Anaraki AN et al: Effect of fentanyl versus buprenorphine on the pupil size in phacoemulsification cataract surgery.
  • Martucci C et al: Chronic fentanyl or buprenorphine infusion in the mouse: similar analgesic profile but different effects on immune responses.
  • Yassen A et al: Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers.
  • Dickenson AH et al: Intrathecal etorphine, fentanyl and buprenorphine on spinal nociceptive neurones in the rat.
  • Pergolizzi J et al: Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705904819.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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50. ||||||||.. 80%  Cooper IF, Siadaty MS: 'Hormones' associated with 'Buprenorphine Fentanyl': Top Publications. BioMedLib Review; Hormone;BuprenorphineFentanyl:705872702. ISSN: 2331-5717. 2014/5/1
PDF icon [Fulltext service] Download fulltext PDF of this article.

  • [Title] 'Hormones' associated with 'Buprenorphine Fentanyl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'hormone' for 'buprenorphine fentanyl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'hormone'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 314 publications.
  • Here are the top 10.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats.
  • Yassen A et al: Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics.
  • Dahan A et al: Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats.
  • Yassen A et al: Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats.
  • van den Berg AA et al: Analgesics and ENT surgery. A clinical comparison of the intraoperative, recovery and postoperative effects of buprenorphine, diclofenac, fentanyl, morphine, nalbuphine, pethidine and placebo given intravenously with induction of anaesthesia.
  • Anaraki AN et al: Effect of fentanyl versus buprenorphine on the pupil size in phacoemulsification cataract surgery.
  • Martucci C et al: Chronic fentanyl or buprenorphine infusion in the mouse: similar analgesic profile but different effects on immune responses.
  • Yassen A et al: Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers.
  • Dickenson AH et al: Intrathecal etorphine, fentanyl and buprenorphine on spinal nociceptive neurones in the rat.
  • Pergolizzi J et al: Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705872702.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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