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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||||||. 100%  Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL: Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum; 2012 Sep;64(9):2907-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement.
  • OBJECTIVE: The modest association between radiographic joint damage and pain in osteoarthritis (OA) has led to the suggestion of facilitated central pain processing.
  • This study evaluated the importance of ongoing tissue pathology in the maintenance of enhanced central pain processing.
  • METHODS: Pain assessment was performed on 48 patients with symptomatic knee OA and 21 sex- and age-matched pain-free healthy control subjects.
  • Pressure-pain thresholds (PPTs) were recorded using a pressure algometer (both over and distant from the knee) and a double-chamber inflatable cuff mounted around the calf.
  • Conditioned pain modulation (CPM) was assessed by recording the increase in PPT in response to experimental arm pain.
  • RESULTS: PPTs at the knee and at sites away from the knee were reduced in OA patients as compared with healthy pain-free control subjects (P < 0.0001).
  • Whereas an elevation of PPTs was noted in the healthy controls in response to experimental arm pain (P < 0.0001), no such CPM was observed in the OA patients.
  • Following joint replacement in the OA patients, there was a reduction in the widespread mechanical hyperesthesia, along with normalization of spatial summation ratios and restoration of CPM.
  • CONCLUSION: The widespread hyperesthesia and enhanced spatial summation observed in OA patients imply sensitized central pain mechanisms together with the loss of CPM.
  • Normalization of the results following joint replacement implies that these central pain processes are maintained by peripheral input.
  • [MeSH-major] Arthroplasty, Replacement, Knee. Hyperesthesia / surgery. Knee Joint / surgery. Nociceptive Pain / surgery. Osteoarthritis, Knee / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Pain Measurement. Treatment Outcome


2. ||||||||.. 77%  Wu J, Raver C, Piao C, Keller A, Faden AI: Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion. Neurotherapeutics; 2013 Jul;10(3):520-38
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  • [Title] Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.
  • Spinal cord injury (SCI) causes not only sensorimotor and cognitive deficits, but frequently also severe chronic pain that is difficult to treat (SCI pain).
  • We previously showed that hyperesthesia, as well as spontaneous pain induced by electrolytic lesions in the rat spinothalamic tract, is associated with increased spontaneous and sensory-evoked activity in the posterior thalamic nucleus (PO).
  • We have also demonstrated that rodent impact SCI increases cell cycle activation (CCA) in the injury region and that post-traumatic treatment with cyclin dependent kinase inhibitors reduces lesion volume and motor dysfunction.
  • Here we examined whether CCA contributes to neuronal hyperexcitability of PO and hyperpathia after rat contusion SCI, as well as to microglial and astroglial activation (gliopathy) that has been implicated in delayed SCI pain.
  • Trauma caused enhanced pain sensitivity, which developed weeks after injury and was correlated with increased PO neuronal activity.
  • Increased CCA was found at the thoracic spinal lesion site, the lumbar dorsal horn, and the PO.
  • Increased microglial activation and cysteine-cysteine chemokine ligand 21 expression was also observed in the PO after SCI.
  • In vivo, post-injury treatment with a selective cyclin dependent kinase inhibitor (CR8) significantly reduced cell cycle protein induction, microglial activation, and neuronal activity in the PO nucleus, as well as limiting chronic SCI-induced hyperpathia.
  • These results suggest a mechanistic role for CCA in the development of SCI pain, through effects mediated in part by the PO nucleus.
  • [MeSH-major] Cell Cycle / physiology. Gene Expression Regulation / physiology. Hyperesthesia / etiology. Hyperesthesia / pathology. Posterior Thalamic Nuclei / physiopathology. Spinal Cord Injuries / complications
  • [MeSH-minor] Action Potentials / drug effects. Animals. Cell Proliferation / drug effects. Cells, Cultured. Cyclins / pharmacology. Cyclins / therapeutic use. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Exploratory Behavior / drug effects. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Gliosis / drug therapy. Gliosis / etiology. Male. Microglia / chemistry. Microglia / metabolism. Microglia / pathology. Nerve Fibers, Unmyelinated / pathology. Neurons / drug effects. Pain Threshold / drug effects. Pain Threshold / physiology. Rats. Rats, Sprague-Dawley. Time Factors

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  • (PMID = 23775067.001).
  • [ISSN] 1878-7479
  • [Journal-full-title] Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
  • [ISO-abbreviation] Neurotherapeutics
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS054221; United States / NINDS NIH HHS / NS / R01 NS054221; United States / NINDS NIH HHS / NS / R01 NS066965; United States / NINDS NIH HHS / NS / R01 NS066965
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclins; 0 / Enzyme Inhibitors; 0 / Glial Fibrillary Acidic Protein
  • [Other-IDs] NLM/ PMC3701760
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3. |......... 13%  Cooper IF, Siadaty MS: 'Findings' associated with 'Heightened Sensation': Top Publications. BioMedLib Review; Finding;HeightenedSensation:706137460. ISSN: 2331-5717. 2014/7/23
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  • [Title] 'Findings' associated with 'Heightened Sensation': Top Publications.
  • There are articles published each month which present 'Finding' for 'heightened sensation'.
  • Baba M: Hyperesthesia: an early manifestation of diabetic polyneuropathy.
  • Capurro R: HYPERESTHESIA OF THE POSTERIOR PERITONEUM IN APPENDICITIS AND OTHER VISCERAL LESIONS.
  • Király A et al: [Investigation of visceral hyperesthesia in irritable bowel syndrome].
  • Gordon AG: Creativity, hyperesthesia, and mental illness.
  • Lombard MC et al: [Chronic hyperesthesia in rats caused by lesions in the dorsal roots of the branchial plexus].
  • Bulgakova AI et al: [Optimization of treatment of wedge-shaped tooth defects with hyperesthesia].
  • Denny-Brown D et al: Hyperesthesia from spinal and root lesions.
  • Svensson P et al: Mechanical hyperesthesia of human facial skin induced by tonic painful stimulation of jaw muscles.
  • Roberts R et al: Erysipelaslike lesions and hyperesthesia as manifestations of Pseudomonas aeruginosa sepsis.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706137460.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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4. |......... 12%  Wu J, Renn CL, Faden AI, Dorsey SG: TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. J Neurosci; 2013 Jul 24;33(30):12447-63
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  • [Title] TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways.
  • Spinal cord injury (SCI) frequently causes severe, persistent central neuropathic pain that responds poorly to conventional pain treatments.
  • Brain-derived neurotrophic factor (BDNF) signaling appears to contribute to central sensitization and nocifensive behaviors in certain animal models of chronic pain through effects mediated in part by the alternatively spliced truncated isoform of the BDNF receptor tropomyosin-related kinase B.T1 (trkB.T1).
  • Mechanisms linking trkB.T1 to SCI-induced chronic central pain are unknown.
  • Here, we examined the role of trkB.T1 in central neuropathic pain after spinal cord contusion.
  • Genetic deletion of trkB.T1 in mice significantly reduced post-SCI mechanical hyperesthesia, locomotor dysfunction, lesion volumes, and white matter loss.
  • TGFβ-induced reactive astrocytes from WT mice showed increased cell cycle protein expression that was significantly reduced in astrocytes from trkB.T1(-/-) mice that express neither full-length trkB nor trkB.T1.
  • Administration of CR8, which selectively inhibits cyclin-dependent kinases, reduced hyperesthesia, locomotor deficits, and dorsal horn (SDH) glial changes after SCI, similar to trkB.T1 deletion, without altering trkB.T1 protein expression.
  • These data indicate that trkB.T1 contributes to the pathobiology of SCI and SCI pain through modulation of cell cycle pathways and suggest new therapeutic targets.
  • [MeSH-minor] Animals. Astrocytes / cytology. Astrocytes / physiology. Brain-Derived Neurotrophic Factor / metabolism. Cell Cycle / physiology. Hyperesthesia / genetics. Hyperesthesia / pathology. Hyperesthesia / physiopathology. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Posterior Horn Cells / physiology. Primary Cell Culture. Recovery of Function / physiology. Up-Regulation / physiology

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  • (PMID = 23884949.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NINR NIH HHS / NR / R01 NR010207; United States / NINR NIH HHS / NR / R01 NR013601; United States / NINR NIH HHS / NR / R01 NR013601; United States / NINDS NIH HHS / NS / R01 NS054221
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; EC 2.7.10.1 / Receptor, trkB
  • [Other-IDs] NLM/ PMC3721848
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5. |......... 12%  Bozynski CC, Vasquez L, O'Brien DP, Johnson GC: Compressive myelopathy associated with ectasia of the vertebral and spinal arteries in a dog. Vet Pathol; 2012 Sep;49(5):779-83
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  • A 4-year-old dog was presented for acute, progressive tetraparesis and cervical hyperesthesia.
  • [MeSH-minor] Animals. Dogs. Fibrosis / pathology. Hyperesthesia / etiology. Hyperesthesia / pathology. Hyperesthesia / veterinary. Magnetic Resonance Imaging / veterinary. Male. Neck / pathology. Radiculopathy / etiology. Radiculopathy / pathology. Radiculopathy / veterinary

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  • (PMID = 21856870.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. |......... 11%  Cooper IF, Siadaty MS: 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Heightened Sensation': Top Publications. BioMedLib Review; BodyPartOrgan;HeightenedSensation:706347964. ISSN: 2331-5717. 2014/1/25
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  • [Title] 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Heightened Sensation': Top Publications.
  • There are articles published each month which present 'Body Part Organ or Organ Component' for 'heightened sensation'.
  • Wu J et al: Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.
  • Yamamoto T et al: Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors.
  • Király A et al: [Investigation of visceral hyperesthesia in irritable bowel syndrome].
  • Bódis L et al: Clinical aspects of carotid sinus hyperaesthesia.
  • Lombard MC et al: [Chronic hyperesthesia in rats caused by lesions in the dorsal roots of the branchial plexus].
  • Tengtrisorn S et al: Persistent infra-orbital nerve hyperaesthesia after blunt orbital trauma.
  • Mizisin AP et al: Tactile hyperesthesia, altered epidermal innervation and plantar nerve injury in the hindfeet of rats housed on wire grates.
  • Shir Y et al: A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats.
  • Seidner S: [Treatment of hyperesthesia of the tooth cervix by means of fluoride iontophoresis].
  • Lambert A: [Hyperesthesia syndrome of dentin and gingiva].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706347964.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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7. |||||||||. 180%  Ciribassi J: Understanding behavior: feline hyperesthesia syndrome. Compend Contin Educ Vet; 2009 Mar;31(3):E10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Understanding behavior: feline hyperesthesia syndrome.
  • The etiology of feline hyperesthesia syndrome can be difficult to determine.
  • [MeSH-major] Behavior, Animal. Cat Diseases / diagnosis. Hyperesthesia / veterinary

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  • [CommentIn] Compend Contin Educ Vet. 2009 Jun;31(6):E4; author reply E4 [23710493.001]
  • (PMID = 19412901.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antidepressive Agents, Tricyclic; 0 / Serotonin Uptake Inhibitors; 12794-10-4 / Benzodiazepines
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8. |||||||||. 124%  Bulgakova AI, Islamova DM, Valeev IV, Davydova SV: [Optimization of treatment of wedge-shaped tooth defects with hyperesthesia]. Stomatologiia (Mosk); 2013;92(1):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Optimization of treatment of wedge-shaped tooth defects with hyperesthesia].
  • Development of tooth wedge-shaped defect leads to a gradual loss of hard tissue and is characterized by pain.
  • Most often patients complain of pain and aesthetic defect that adversely affects the emotional status and quality of life.
  • Search for adequate means and methods of treatment providing increased resistance of dental hard tissues and reducing hyperesthesia is challenging for dentists.
  • Wedge-shaped defect and hyperesthesia as concomitant symptom was found in the city of Ufa in the 5.65 and 63.0% of dental patients, respectively.
  • [MeSH-major] Hyperesthesia / epidemiology. Hyperesthesia / therapy. Tooth Abrasion / epidemiology. Tooth Abrasion / therapy. Tooth Erosion / epidemiology. Tooth Erosion / therapy

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  • (PMID = 23528402.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii͡a
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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9. |||||||||. 121%  Wesley CK, Unger RH, Rosenberg M, Unger MA, Unger WP: Factors influencing postoperative hyperesthesia in hair restoration surgery. J Cosmet Dermatol; 2011 Dec;10(4):301-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors influencing postoperative hyperesthesia in hair restoration surgery.
  • We investigated the technical and demographic variables that may contribute to the frequency of postoperative hyperesthesia.
  • RESULTS:   A total of 19 patients (3.4%) reported postoperative hyperesthesia in either the donor or recipient area of their scalp.
  • Although many trends emerged, one variable significantly influenced the rate of this neurosensory symptom.
  • While no patient who had all previous and current HRS sessions performed entirely within the same investigated surgical practice (n=42) experienced postoperative hyperesthesia, 14% of our patients who underwent prior HRS by a physician outside of the investigated surgical group (n=35) developed this complication (P=0.0404).
  • The amount of intraoperative electrocautery to maintain hemostasis (P=0.0897), degree of tension upon donor wound closure (P=0.3044), and extent of donor wound edge undermining (P=0.4420) influenced the frequency of this sequela to a lesser degree.
  • CONCLUSION:   These results suggest that physicians planning repair sessions on patients who have undergone prior HRS by a physician at a different surgical center should include the specific caveat of increased incidences of postoperative hyperesthesia in their preoperative consultation.
  • [MeSH-major] Cosmetic Techniques / adverse effects. Hair Follicle / transplantation. Hyperesthesia / etiology. Scalp / surgery

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  • [Copyright] © 2011 Wiley Periodicals, Inc.
  • (PMID = 22151939.001).
  • [ISSN] 1473-2165
  • [Journal-full-title] Journal of cosmetic dermatology
  • [ISO-abbreviation] J Cosmet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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10. |||||||||. 117%  Waldinger MD, Venema PL, van Gils AP, Schweitzer DH: New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis. J Sex Med; 2009 Oct;6(10):2778-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis.
  • The localizations of genital sensations were investigated by physical examination of the ramus inferior of the pubic bone (RIPB) and by sensory testing of the skin of the genital area with a cotton swab (genital tactile mapping test or GTM test).
  • MAIN OUTCOME MEASURES: Sensitivity of RIPB, GTM test.
  • RESULTS: Of 23 women included in the study, 18(78%), 16(69%), and 12(52%) reported restless legs syndrome, overactive bladder syndrome, and urethra hypersensitivity.
  • Finger touch investigation of the dorsal nerve of the clitoris (DNC) along the RIPB provoked ReGS in all women.
  • Sensory testing showed unilateral and bilateral static mechanical Hyperesthesia on various trigger points in the dermatome of the pudendal nerve, particularly in the part innervated by DNC, including pelvic bone.
  • Physical examination for static mechanical Hyperesthesia is a diagnostic test for ReGS and is recommended for all individuals with complaints of persistent restless genital arousal in absence of sexual desire.
  • [MeSH-major] Clitoris / physiopathology. Hyperesthesia / complications. Peripheral Nervous System Diseases / complications. Sexual Dysfunction, Physiological / etiology


11. |||||||||. 106%  de Lorimier LP: Feline hyperesthesia syndrome. Compend Contin Educ Vet; 2009 Jun;31(6):E4; author reply E4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Feline hyperesthesia syndrome.
  • [MeSH-major] Behavior, Animal. Cat Diseases / diagnosis. Hyperesthesia / veterinary

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  • [CommentOn] Compend Contin Educ Vet. 2009 Mar;31(3):E10 [19412901.001]
  • (PMID = 23710493.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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12. |||||||... 67%  Zhou XZ: [Hyperesthesia of back induced by cervical spondylopathy]. Zhongguo Gu Shang; 2010 Sep;23(9):722
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Hyperesthesia of back induced by cervical spondylopathy].
  • [MeSH-major] Cervical Vertebrae. Hyperesthesia / etiology. Spondylosis / complications

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  • (PMID = 20964013.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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13. |||||..... 53%  Marek I, Metzler M, Reutter G, Holter W: Recurrent fever episodes with arthralgia or hyperesthesia--have you ruled out parvovirus B19? Klin Padiatr; 2010 Nov;222(6):397-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent fever episodes with arthralgia or hyperesthesia--have you ruled out parvovirus B19?
  • [MeSH-major] Arthralgia / etiology. Erythema Infectiosum / diagnosis. Fever of Unknown Origin / etiology. Hyperesthesia / etiology. Parvovirus B19, Human

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  • (PMID = 20806168.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


14. ||........ 15%  Tostova OO, Chestnykh EV, Iusufova MV: [Infiltration of enamel erosions as a part of combined dental care in gastroesophageal reflux disease]. Stomatologiia (Mosk); 2013;92(2):15-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Infiltration of enamel erosions as a part of combined dental care in gastroesophageal reflux disease].
  • The paper presents the results of evaluation of clinical efficacy of the Icon infiltration method for the treatment of tooth enamel erosion associated with gastroesophageal reflux disease (GERD).
  • Twenty-seven teeth were treated, and the degree of dental hard tissues hyperesthesia reduction as well as the dynamics of erosions size was estimated.
  • It was proved that in most part of cases hyperesthesia deceased significantly and there were no increase in the erosions area during the follow-up period.
  • [MeSH-major] Dental Enamel. Gastroesophageal Reflux / complications. Hyperesthesia / drug therapy. Resins, Synthetic / therapeutic use. Tooth Erosion / drug therapy

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  • (PMID = 23715445.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii͡a
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Resins, Synthetic; 0 / icon infiltrant
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15. |......... 11%  Waldinger MD, Venema PL, van Gils AP, de Lint GJ, Schweitzer DH: Stronger evidence for small fiber sensory neuropathy in restless genital syndrome: two case reports in males. J Sex Med; 2011 Jan;8(1):325-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Restless genital syndrome (ReGS) is characterized by unwanted, unpleasant genital sensations, restless legs, and/or overactive bladder, as well as neuropathy of the dorsal nerve of the clitoris.
  • METHODS: Two males with unwanted genital sensations presented in our clinic.
  • RESULTS: ReGS in a 74-year-old male manifested as unpleasant genital sensations of being on the edge of an orgasm with overactive bladder, in the absence of erection and ejaculation.
  • Genital sensory testing elicited bilateral points of static mechanical hyperesthesia in the pudendal dermatome.
  • Manual examination of the dorsal nerve of the penis (DNP) elicited the genital sensations.
  • TENS application resulted in a 90% reduction of genital sensations and complaints of overactive bladder syndrome (OAB).
  • Genital sensory testing elicited bilateral points of static mechanical hyperesthesia in the pudendal dermatome.
  • Manual examination of the DNP elicited the genital sensations.
  • This notion and the finding of typical sensory abnormalities of the genital end branches of the pudendal nerve in males and females--as previously reported--provides strong evidence for Small Fiber Sensory Neuropathy as a common cause of ReGS.
  • [MeSH-major] Hyperesthesia. Peripheral Nervous System Diseases. Restless Legs Syndrome. Sexual Dysfunction, Physiological. Urinary Bladder, Overactive


16. |......... 10%  Ait Benhaddou E, Zinebi A, Elhassani M, Raissouni L, Elhassani MR, Benomar A, Yahyaoui M: [Pachymeningitis associated with probable Horton's disease: a case report]. Rev Neurol (Paris); 2010 Feb;166(2):253-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pachymeningitis associated with probable Horton's disease: a case report].
  • INTRODUCTION: Horton's disease is the most common vasculitis of elder people.
  • OBSERVATION: A 71-year-old patient who presented headache, hyperesthesia of the scalp, weight loss with a biological inflammatory syndrome and meningeal thickening on MRI.
  • The diagnosis of pachymeningitis related to Horton's disease was retained.
  • CONCLUSION: Horton's disease is a potential diagnosis in elderly persons with pachymeningitis and inflammatory syndrome.
  • [MeSH-minor] Aged. Dura Mater / pathology. Female. Headache / etiology. Humans. Hyperesthesia / drug therapy. Hyperesthesia / etiology. Inflammation / pathology. Magnetic Resonance Imaging. Meninges / anatomy & histology. Meninges / drug effects. Meninges / pathology. Meningitis / etiology. Scalp / physiopathology

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  • [Copyright] Copyright 2009. Published by Elsevier Masson SAS.
  • (PMID = 19497602.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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17. |......... 9%  Fessa CK, Lee BS: An Australian case of surfer's myelopathy. Clin J Sport Med; 2012 May;22(3):281-3
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  • We present a 19-year-old man who developed lower back pain, profound bilateral lower limb paraparesis, and hyperesthesia during his first learn to surf class.
  • [MeSH-minor] Analgesics / therapeutic use. Australia. Humans. Hyperesthesia / diagnosis. Low Back Pain / diagnosis. Low Back Pain / drug therapy. Magnetic Resonance Imaging. Male. Paraparesis / diagnosis. Paraplegia / diagnosis. Severity of Illness Index. Spinal Cord Ischemia / diagnosis. Young Adult

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  • (PMID = 22544059.001).
  • [ISSN] 1536-3724
  • [Journal-full-title] Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
  • [ISO-abbreviation] Clin J Sport Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics
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18. |......... 9%  Mbelesso P, Yogo ML, Yangatimbi E, Paul-Sénékian Vd, Nali NM, Preux PM: [Outbreak of konzo disease in health region No. 2 of the Central African Republic]. Rev Neurol (Paris); 2009 May;165(5):466-70
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  • [Title] [Outbreak of konzo disease in health region No. 2 of the Central African Republic].
  • INTRODUCTION: Konzo is a neuromyelopathy characterized by permanent spastic paraparesis, linked to a subacute poisoning by cyanide found in cassava.
  • The predominant neurological signs were lower limb paresis (90.0%) and hyperesthesia (66.7%).
  • [MeSH-minor] Adolescent. Central African Republic / epidemiology. Child. Child, Preschool. Disease Outbreaks. Female. Humans. Hyperesthesia / etiology. Male. Vision Disorders / etiology. Visual Acuity

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  • (PMID = 19081587.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


19. |......... 9%  Griffin JF 4th, Levine J, Kerwin S, Cole R: Canine thoracolumbar invertebral disk disease: diagnosis, prognosis, and treatment. Compend Contin Educ Vet; 2009 Mar;31(3):E3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canine thoracolumbar invertebral disk disease: diagnosis, prognosis, and treatment.
  • Thoracolumbar intervertebral disk disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incontinence in dogs.

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  • (PMID = 19412898.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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20. |......... 8%  Ahmed Z, Powell R, Llewelyn G, Anstey A: Chronic inflammatory demyelinating polyradiculoneuropathy complicating anti TNF α therapy for chronic plaque psoriasis. BMJ Case Rep; 2011;2011
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 53-year-old woman with chronic plaque psoriasis treated with adalimumab (antitumour necrosis factor (anti TNF) α therapy) for 10 months presented with an 8 week history of hyperesthesia in a 'glove and stocking' distribution and clumsiness on walking.
  • Nerve conduction studies confirmed the clinical diagnosis of a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

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  • [Cites] Arthritis Rheum. 2001 Sep;44(9):1977-83 [11592357.001]
  • [Cites] Electromyogr Clin Neurophysiol. 2004 Mar;44(2):95-102 [15061403.001]
  • [Cites] Clin Exp Rheumatol. 2004 Sep-Oct;22(5 Suppl 35):S134-40 [15552527.001]
  • [Cites] Arch Neurol. 2009 Apr;66(4):490-7 [19364934.001]
  • [Cites] Muscle Nerve. 2010 May;41(5):723-7 [20405504.001]
  • (PMID = 22674940.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Monoclonal, Humanized; 0 / Immunoglobulins, Intravenous; 0 / Tumor Necrosis Factor-alpha; FYS6T7F842 / adalimumab
  • [Other-IDs] NLM/ PMC3229329
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21. |......... 8%  Kumar R, Aggarwal A, Faridi MM: Complex regional pain syndrome type 1 and scurvy. Indian Pediatr; 2009 Jun;46(6):529-31
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  • [Title] Complex regional pain syndrome type 1 and scurvy.
  • A 5 year old female developed features of complex regional pain syndrome (CRPS) i.e excessive pain to touch, decreased sweating and edema of left ankle 2 years after fracture of left tibia.
  • Hyperesthesia improved and child walked with support following administration of vitamin C.


22. |......... 8%  Vieira AH, Santiago SL: Management of dentinal hypersensitivity. Gen Dent; 2009 Mar-Apr;57(2):120-6; quiz 127-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of dentinal hypersensitivity.
  • Dentinal hypersensitivity is a complex condition that can cause considerable concern in the dental office.
  • Selecting the right therapy requires a complete understanding of how applying a stimulus to the exposed dentin surface can influence the nerve fibers and produce hyperesthesia.
  • This article reviews the etiology and critically analyzes management of dentinal hypersensitivity by reviewing laboratory and clinical investigations.
  • [MeSH-major] Dentin Sensitivity / therapy

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  • (PMID = 19552361.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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23. |......... 8%  Griffin JF 4th, Levine J, Kerwin S: Canine thoracolumbar invertebral disk disease: pathophysiology, neurologic examination, and emergency medical therapy. Compend Contin Educ Vet; 2009 Mar;31(3):E2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Canine thoracolumbar invertebral disk disease: pathophysiology, neurologic examination, and emergency medical therapy.
  • Thoracolumbar intervertebral disk disease (IVDD) is a common, important cause of paraspinal hyperesthesia, pelvic limb ataxia, paraparesis, paraplegia, and urinary and fecal incontinence in dogs.

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  • (PMID = 19412899.001).
  • [ISSN] 1940-8315
  • [Journal-full-title] Compendium (Yardley, PA)
  • [ISO-abbreviation] Compend Contin Educ Vet
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  •  go-up   go-down


24. |......... 8%  Park C, Kang BT, Yoo JH, Park HM: Syringomyelia in three small breed dogs secondary to Chiari-like malformation: clinical and diagnostic findings. J Vet Sci; 2009 Dec;10(4):365-7
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  • Upon physical and neurologic examination, all dogs displayed hyperesthesia, pain, and neck stiffness.

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  • [Cites] Aust Vet J. 2000 Feb;78(2):92-5 [10736666.001]
  • [Cites] J Neurosurg. 2004 Mar;100(3 Suppl Spine):241-4 [15029911.001]
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  • (PMID = 19934606.001).
  • [ISSN] 1976-555X
  • [Journal-full-title] Journal of veterinary science
  • [ISO-abbreviation] J. Vet. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Diuretics; 7LXU5N7ZO5 / Furosemide; 9PHQ9Y1OLM / Prednisolone
  • [Other-IDs] NLM/ PMC2807277
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25. |......... 7%  Karmacharya P, Shah K, Pathak R, Ghimire S, Alweis R: Touch me not. J Community Hosp Intern Med Perspect; 2014;4
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  • [Title] Touch me not.
  • Central Poststroke Pain syndrome (CPSP) can occur due to disruption of the somatosensory pathways of the brain at any level such as the thalamus, medulla, or cerebral cortex.
  • It is characterized by sensory abnormalities and hyperesthesia in the part of the body correlating to the central lesion.
  • The treatment of this pain syndrome is often difficult, and it does not usually respond to traditional analgesics.

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  • (PMID = 24596647.001).
  • [ISSN] 2000-9666
  • [Journal-full-title] Journal of community hospital internal medicine perspectives
  • [ISO-abbreviation] J Community Hosp Intern Med Perspect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC3937561
  • [Keywords] NOTNLM ; Central Poststroke Pain / Déjerine Roussy syndrome / gabapentin / neuropathic pain / thalamic pain syndrome
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26. |......... 7%  Waldinger MD, Venema PL, van Gils AP, Schutter EM, Schweitzer DH: Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: a case report. J Sex Med; 2010 Feb;7(2 Pt 2):1029-34
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  • INTRODUCTION: Females despairing of restless genital syndrome (ReGS) may request clitoridectomy for treatment of unwanted genital sensations. Aim.
  • METHODS: Following a clitoridectomy for spontaneous orgasms, a 77-year-old woman was referred to our clinic for persistent unwanted genital sensations and feelings of imminent orgasm.
  • The localizations of genital sensations were investigated by manual examination of the ramus inferior of the pubic bone (RIPB) and by sensory testing of the skin of the genital area with a cotton swab.
  • MAIN OUTCOME MEASURES: The main outcome measures included sensitivity of dorsal nerve of the clitoris in RIPB and MRI-pelvis.
  • Sensory testing of the genital area showed various points of static mechanical hyperesthesia at the left dermatome of the pudendal nerve.
  • Manual examination of the RIPB also elicited the genital sensations at the left side of the vagina at about the 3 o'clock position.
  • [MeSH-major] Circumcision, Female. Genitalia, Female / physiopathology. Sensation Disorders / etiology. Sexual Dysfunctions, Psychological / surgery
  • [MeSH-minor] Aged. Clitoris / innervation. Clitoris / pathology. Clitoris / physiopathology. Electroencephalography. Female. Humans. Hyperesthesia / surgery. Magnetic Resonance Imaging. Pubic Bone / innervation. Syndrome. Time Factors

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  • (PMID = 19912500.001).
  • [ISSN] 1743-6109
  • [Journal-full-title] The journal of sexual medicine
  • [ISO-abbreviation] J Sex Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. |......... 7%  Osgood DB, Harrington WF, Kenney EV, Harrington JF: The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats. Surg Neurol Int; 2013;4:106
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  • In an experimental model, elevated epidural glutamate concentrations in the lumbar spine can cause a focal hyperesthetic state.
  • RESULTS: The kainic acid antagonist, UBP 301, decreased epidural glutamate-based hyperesthesia in a dose dependent manner.
  • The N-Methyl-4-isoxazoleproionic acid (NMDA) antagonist Norketamine also significantly diminished hyperesthesia and decreased receptor expression in the dorsal horn.

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  • (PMID = 24032081.001).
  • [ISSN] 2229-5097
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3766326
  • [Keywords] NOTNLM ; Glutamate / UBP 301 / nociception / norketamine
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28. |......... 7%  Cruz-Arámbulo R, Nykamp S: Acute intraparenchymal spinal cord injury in a cat due to high-rise syndrome. Can Vet J; 2012 Mar;53(3):274-8
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  • The cat had paraplegia of the hind limbs, intact reflexes and pain perception, and hyperesthesia in the caudal thoracic area.

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  • [Cites] J Feline Med Surg. 2002 Mar;4(1):65-8 [11869056.001]
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  • (PMID = 22942443.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal. La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3280780
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29. |......... 7%  Wildgaard K, Ringsted TK, Aasvang EK, Ravn J, Werner MU, Kehlet H: Neurophysiological characterization of persistent postthoracotomy pain. Clin J Pain; 2012 Feb;28(2):136-42
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  • [Title] Neurophysiological characterization of persistent postthoracotomy pain.
  • OBJECTIVES: The postthoracotomy pain syndrome (PTPS) has a prevalence of 30% to 40%.
  • Although intraoperative nerve damage during thoracotomy has been demonstrated, it has not been clearly linked to PTPS and detailed quantitative sensory characterization data have so far not been presented, comparing PTPS and pain-free patients.
  • METHODS: Neurophysiological characterization was performed in 17 patients with PTPS and 24 pain-free postthoracotomy patients using a detailed quantitative sensory testing protocol and psychometric questionnaires.
  • RESULTS: Pain and pain-free patients had increased thresholds to tactile detection (P=0.001 and P=0.01) and cool detection (P<0.001 and P<0.01) on the operated side versus the contralateral side.
  • Pain patients also had increased thresholds for warmth detection (P<0.001) and heat pain (P<0.01) on the operated side.
  • The PTPS patients demonstrated increased side-to-side differences for warmth detection (P<0.01), heat pain (P<0.05), and cool detection (P<0.05) thresholds compared with pain-free patients.
  • Pain patients also more frequently experienced cool hyperesthesia (8 of 17 vs. 1 of 24, P<0.01), but no differences were found for pressure pain, temporal summation, or sensory mapping to cool (200 cm vs. 76 cm, P=0.18).
  • Hospital Anxiety and Depression Scale scores were higher for PTPS than for pain-free patients (P<0.01).
  • DISCUSSION: Neurophysiological assessments indicate nerve injury to be common in pain and pain-free patients after thoracotomy.
  • The combination of increased thresholds together with hyperesthesia, suggests consequences of nerve injury to be more pronounced in PTPS patients.
  • [MeSH-major] Chest Pain / diagnosis. Chest Pain / etiology. Chest Pain / physiopathology. Chronic Pain / etiology. Chronic Pain / physiopathology. Pain Measurement / methods. Thoracotomy / adverse effects
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged

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  • (PMID = 21705872.001).
  • [ISSN] 1536-5409
  • [Journal-full-title] The Clinical journal of pain
  • [ISO-abbreviation] Clin J Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. |......... 7%  Havton LA: A lumbosacral ventral root avulsion injury and repair model for studies of neuropathic pain in rats. Methods Mol Biol; 2012;851:185-93
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  • [Title] A lumbosacral ventral root avulsion injury and repair model for studies of neuropathic pain in rats.
  • Neuropathic pain may develop after a variety of injuries to peripheral nerves and roots.
  • Recently, it has been demonstrated that injury to motor fibers in ventral roots may also result in neuropathic pain.
  • A lumbosacral ventral root avulsion injury results in acute and persistent mechanical allodynia, but not thermal hyperesthesia.
  • Interestingly, an acute replantation of the avulsed ventral roots into the spinal cord results in amelioration of the neuropathic pain.

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  • (PMID = 22351091.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS042719
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. |......... 7%  Tseng YT, Tsai HC, Sy CL, Lee SS, Wann SR, Wang YH, Chen JK, Wu KS, Chen YS: Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan. J Microbiol Immunol Infect; 2011 Oct;44(5):382-9
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  • Most of the patients presented with headache (29, 78%), fever (25, 68%), and 11(30%) had hyperesthesia.
  • Patients with hyperesthesia had longer incubation period (55 vs. 7 days, p=0.004), lower serum immunoglobulin E levels (127.5 vs. 1295 IU/mL, p<0.001), and longer duration between symptom onset and spinal taps (14 vs. 5 days, p=0.011).
  • Magnetic resonance imaging of the brain disclosed leptomeningeal enhancement (17/26, 65%) and increased signal intensity (10/26, 38%) on T2-weighted and fluid-attenuated inversion recovery images.
  • Hyperesthesia; repeated lumbar puncture in cases with lymphocytic meningitis of uncertain cause; and a detailed history, including food consumption, are important to establish an accurate diagnosis.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Animals. Child. Child, Preschool. Clinical Laboratory Techniques / methods. Disease Outbreaks. Female. Humans. Male. Middle Aged. Parasitology / methods. Retrospective Studies. Taiwan / epidemiology. Young Adult

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  • [Copyright] Copyright © 2011. Published by Elsevier B.V.
  • (PMID = 21524976.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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32. |......... 7%  Gustorff B, Sycha T, Lieba-Samal D, Rolke R, Treede RD, Magerl W: The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization. Pain; 2013 Apr;154(4):586-97
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  • Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent nonirradiated skin were studied in 22 healthy subjects 24h after irradiation with UVB at 3-fold minimal erythema dose of a skin area 5 cm in diameter at the thigh and compared to mirror-image contralateral control areas.
  • Within the sunburn area, cold hyperesthesia (P=.01), profound generalized hyperalgesia to heat (P<.001), cold (P<.05), pinprick and pressure (P<.001), and mild dynamic mechanical allodynia (P<.001) were present.
  • The finding of cold hyperalgesia and cold hyperesthesia is new in this model.
  • These data reveal that the UVB sunburn model activates a broad spectrum of peripheral and central sensitization mechanisms and hence is a useful human surrogate model to be used as a screening tool for target engagement in phases 1 and 2a of drug development.
  • [MeSH-major] Central Nervous System Sensitization / physiology. Hyperalgesia / etiology. Pain Threshold / physiology. Sunburn / complications
  • [MeSH-minor] Adult. Analysis of Variance. Dose-Response Relationship, Radiation. Female. Humans. Laser-Doppler Flowmetry. Male. Neural Pathways / physiology. Pain Measurement. Physical Stimulation / adverse effects. Psychophysics. Skin / blood supply. Time Factors. Ultraviolet Rays / adverse effects. Vibration. Young Adult

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  • [Copyright] Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
  • (PMID = 23419598.001).
  • [ISSN] 1872-6623
  • [Journal-full-title] Pain
  • [ISO-abbreviation] Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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33. |......... 7%  Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND: Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses. J Am Vet Med Assoc; 2010 Oct 1;237(7):812-22
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  • Gait asymmetry and cervical hyperesthesia were frequently detected in horses with CVM.
  • CONCLUSIONS AND CLINICAL RELEVANCE: Odds of a diagnosis of CVM were greater in young horses and horses of specific breeds.
  • Detection of gait asymmetry and cervical hyperesthesia were frequently reported in association with CVM.

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  • (PMID = 20919847.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. |......... 7%  Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F: 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett; 2011 Sep 15;21(18):5234-8
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  • In general compounds with bulkier side chains displayed increased selectivity for nNOS over eNOS and iNOS isoforms.
  • One of the compounds, (R)-8 was shown to reduce tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in an in vivo rat model of dural inflammation relevant to migraine pain.

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21824773.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Indoles; EC 1.14.13.39 / Nitric Oxide Synthase
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35. |......... 6%  Heij L, Dahan A, Hoitsma E: Sarcoidosis and pain caused by small-fiber neuropathy. Pain Res Treat; 2012;2012:256024
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  • [Title] Sarcoidosis and pain caused by small-fiber neuropathy.
  • Sarcoidosis is a chronic inflammatory illness and small-fiber neuropathy (SFN) is one of the disabling and often chronic manifestations of the disease.
  • SFN presents with peripheral pain and symptoms of autonomic dysfunction.
  • The character of the pain can be burning or shooting.
  • Besides, allodynia and hyperesthesia can exist.
  • The aim of treatment is often to reduce pain; however, total pain relieve is seldom achieved.

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  • (PMID = 23304492.001).
  • [ISSN] 2090-1550
  • [Journal-full-title] Pain research and treatment
  • [ISO-abbreviation] Pain Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3523152
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36. |......... 6%  Kitamura Y, Sakakura N, Uchida T, Suyama M: [Neurinoma arising from brachial plexus with intrathoracic extension resected through the second intercostal space]. Kyobu Geka; 2010 Dec;63(13):1133-5
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  • The tumor was resected through the 2nd intercostal space under an axillary skin incision approach and diagnosed as neurinoma on histological examination.
  • He had a complaint of hyperesthesia of the right upper arm for 2 months postoperatively.

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  • (PMID = 21174662.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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37. |......... 6%  Johansen A, Romundstad L, Nielsen CS, Schirmer H, Stubhaug A: Persistent postsurgical pain in a general population: prevalence and predictors in the Tromsø study. Pain; 2012 Jul;153(7):1390-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent postsurgical pain in a general population: prevalence and predictors in the Tromsø study.
  • Population-based data on the prevalence of persistent postsurgical pain are scarce.
  • This study aimed to assess the prevalence of persistent postsurgical pain in a general population and to describe associated physical, social, and psychological factors, including symptoms of nerve injury and sensitization.
  • A cross-sectional survey was performed in northern Norway with questionnaire items covering surgery, pain, and sensory abnormalities in the area of surgery.
  • Persistent pain in the area of surgery was reported by 40.4% of the patients (826 of 2043), moderate or severe pain by 18.3% (373 of 2043).
  • Hypoesthesia, hyperesthesia, or both was reported by 24.5% (501 of 2043).
  • There were strong associations between sensory abnormalities and persistent pain, increasingly with higher pain intensities; odds ratios were 2.68 for hypoesthesia and 6.27 for hyperesthesia.
  • Of the 826 individuals reporting persistent pain in the anatomical area of surgery, 51.0% reported chronic pain when questioned without specific reference to the surgery.
  • The present study supports evidence from clinical studies of persistent postsurgical pain, indicating a high prevalence, but reveals large discrepancies in report of pain, depending on the questions asked and the context in which the questions are presented.
  • Strong associations between sensory abnormalities and pain indicate neuropathic mechanisms in a major proportion of cases.
  • [MeSH-major] Chronic Pain / epidemiology. Pain, Postoperative / epidemiology
  • [MeSH-minor] Adult. Aged. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Norway / epidemiology. Pain Measurement. Prevalence. Questionnaires. Risk Factors

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  • [Copyright] Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
  • [CommentIn] Pain. 2012 Jul;153(7):1344-5 [22424875.001]
  • (PMID = 22445291.001).
  • [ISSN] 1872-6623
  • [Journal-full-title] Pain
  • [ISO-abbreviation] Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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38. |......... 6%  Hanai S, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Oya Y, Higurashi N, Hamano S: Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev; 2011 Feb;33(2):161-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient presented with fever, erythema of the entire body, and abdominal pain with vomiting.
  • Symptoms such as muscle weakness, severe hyperesthesia, dyshidrosis, and neurogenic bladder associated with autonomic disturbance developed over several days.

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  • [Copyright] Copyright © 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20395090.001).
  • [ISSN] 1872-7131
  • [Journal-full-title] Brain & development
  • [ISO-abbreviation] Brain Dev.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Viral
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39. |......... 6%  De Decker S, De Risio L, Lowrie M, Mauler D, Beltran E, Giedja A, Kenny PJ, Gielen I, Garosi L, Volk H: Cervical vertebral stenosis associated with a vertebral arch anomaly in the Basset Hound. J Vet Intern Med; 2012 Nov-Dec;26(6):1374-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVES: To report the clinical presentation, imaging characteristics, treatment results, and histopathological findings of a previously undescribed vertebral malformation in the Basset Hound.
  • Eighteen Basset Hounds presented for evaluation of a suspected cervical spinal cord problem.
  • Clinical signs varied from cervical hyperesthesia to nonambulatory tetraparesis.
  • CONCLUSIONS AND CLINICAL IMPORTANCE: Dorsal lamina and spinous process hypertrophy leading to ligamentum flavum hypertrophy should be included in the differential diagnosis of Basset Hounds with cervical hyperesthesia or myelopathy.

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  • [Copyright] Copyright © 2012 by the American College of Veterinary Internal Medicine.
  • (PMID = 22978330.001).
  • [ISSN] 1939-1676
  • [Journal-full-title] Journal of veterinary internal medicine / American College of Veterinary Internal Medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. |......... 6%  Richardson BS, Way BV, Speece AJ 3rd: Osteopathic manipulative treatment in the management of notalgia paresthetica. J Am Osteopath Assoc; 2009 Nov;109(11):605-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Symptoms may include pain, hyperesthesia, paresthesia, and hyperpigmentation of the affected area.
  • The authors report the case of a 59-year-old woman with notalgia paresthetica who received one 20-minute session of osteopathic manipulative treatment that focused primarily on thoracic spine and rib somatic dysfunctions.
  • [MeSH-major] Back Pain / therapy. Manipulation, Osteopathic. Paresthesia / therapy

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  • (PMID = 19948695.001).
  • [ISSN] 1945-1997
  • [Journal-full-title] The Journal of the American Osteopathic Association
  • [ISO-abbreviation] J Am Osteopath Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. |......... 6%  Schneider AR, Chen AV, Tucker RL: Imaging diagnosis--Vertebral canal porcupine quill with presumptive secondary arachnoid diverticulum. Vet Radiol Ultrasound; 2010 Mar-Apr;51(2):152-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 3-year-old Gordon Setter developed cervical hyperesthesia and a stiff gait.
  • At a retrospective review of the MR images, the quill appeared as a circular well-demarcated T2-hypointense lesion.

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  • (PMID = 20402400.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. |......... 6%  Sunami K, Takayama M, Okabe Y, Yamane H, Tochino Y, Kodama T, Negoro N: [A case of Churg-Strauss syndrome following corticosteroid withdrawal]. Nihon Jibiinkoka Gakkai Kaiho; 2009 Jun;112(6):487-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • He then developed fever, maniphalanx stiffness, testicular pain, and facial hyperesthesia, eruptions, and the lower-limb numbness.
  • The detection of a positive serum reaction for MPO-ANCA and evaluated of eosinophilic leukocyte levels yielded a definitive diagnosis of CSS, for which the man was treated with predonisolone and cyclophosphamide.

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  • (PMID = 19610591.001).
  • [ISSN] 0030-6622
  • [Journal-full-title] Nihon Jibiinkoka Gakkai kaiho
  • [ISO-abbreviation] Nippon Jibiinkoka Gakkai Kaiho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Glucocorticoids; 9PHQ9Y1OLM / Prednisolone
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43. |......... 6%  Coradini JG, Mattjie TF, Bernardino GR, Peretti AL, Kakihata CM, Errero TK, Escher AR, Bertolini GR: Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats. Rev Bras Reumatol; 2014 Jan-Feb;54(1):7-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats.
  • INTRODUCTION: Both therapeutic ultrasound as a low level laser therapy are used to control musculoskeletal pain, despite controversy about its effects, yet the literature is poor and also presents conflicting results on possible cumulative effects of techniques association.
  • METHODS: 24 Wistar rats were divided into: GPL--induction of hyperesthesia in the right knee, and untreated; GUS--treated with therapeutic ultrasound (1 MHz, 0.4 W/cm2) GL--low intensity laser (830 nm, 8 J/cm2); GL+US--treated with both techniques.
  • To produce the hyperesthesia 100 μl of 5% formalin solution were injected into the tibiofemoral joint space, which was assessed by von Frey filament digital before (EV1), 15 (EV2), 30 (EV3) and 60 (EV4) minutes after induction.

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  • (PMID = 24878785.001).
  • [ISSN] 1809-4570
  • [Journal-full-title] Revista brasileira de reumatologia
  • [ISO-abbreviation] Rev Bras Reumatol
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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44. |......... 6%  Nentwig A, Oevermann A, Burgener IA: [Doramectin intoxication in 3 kittens]. Schweiz Arch Tierheilkd; 2014 Apr;156(4):179-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Subsequently, this kitten developed behavioral changes such as aggression, hyperesthesia, tremors, and seizures and died 36 hours after presentation.

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  • (PMID = 24686818.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; Doramectin / Ivermectin / Polioencephalomalazie / Toxizität / doramectin / epileptiforme Anfälle / ivermectin / polioencephalomalacia / seizures / toxicity
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45. |......... 6%  Russell JH, Joseph SJ, Snell BJ, Jithoo R: Brown-Sequard syndrome associated with Horner's syndrome following a penetrating drill bit injury to the cervical spine. J Clin Neurosci; 2009 Jul;16(7):975-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • As the injury was not a complete hemisection of the spinal cord, the patient presented with ipsilateral motor deficit and hyperesthesia and diminished contralateral fine touch sensation; however, proprioception, vibration and temperature were all initially intact.
  • Over the following 5 days the patient's right-sided motor deficit improved daily; however, he developed a contralateral deficit to pain and temperature upon wakening from the operation which did not resolve.


46. |......... 6%  Putz Z, Tabák AG, Tóth N, Istenes I, Németh N, Gandhi RA, Hermányi Z, Keresztes K, Jermendy G, Tesfaye S, Kempler P: Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance. Diabetes Care; 2009 Jan;32(1):181-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Peak plantar pressure was measured by dynamic pedobarography, and symptoms were graded using the neuropathy total symptom score.
  • They had a higher frequency of both hyperesthesia and hypoesthesia as detected by current perception threshold testing at 5 Hz, as well as increased heat detection thresholds.
  • Cardiovascular autonomic neuropathy may contribute to increased cardiovascular risk in IGT subjects.

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  • [Cites] Diabetes Care. 2001 Aug;24(8):1448-53 [11473085.001]
  • [Cites] Neurology. 2001 Nov 13;57(9):1701-4 [11706115.001]
  • [Cites] Br Med J (Clin Res Ed). 1982 Oct 2;285(6346):916-8 [6811067.001]
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  • [Cites] Muscle Nerve. 2007 Oct;36(4):536-41 [17626290.001]
  • [Cites] N Engl J Med. 2005 Jan 27;352(4):341-50 [15673800.001]
  • [Cites] Clin Ther. 2005 Aug;27(8):1278-94 [16199253.001]
  • [Cites] Diab Vasc Dis Res. 2005 Feb;2(1):9-15 [16305067.001]
  • [Cites] Circulation. 2007 Jan 23;115(3):387-97 [17242296.001]
  • [Cites] Diabet Med. 1996 Nov;13(11):960-6 [8946154.001]
  • (PMID = 18835942.001).
  • [ISSN] 1935-5548
  • [Journal-full-title] Diabetes care
  • [ISO-abbreviation] Diabetes Care
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2606810
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47. |......... 5%  Abdulazim A, Backhaus M, Stienen MN, Citak M, Brokinkel B, Kuhlmann T, Horch C: Intramedullary spinal cord metastasis and multiple brain metastases from urothelial carcinoma. J Clin Neurosci; 2011 Oct;18(10):1405-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, their incidence is expected to increase as a result of advances in diagnostic techniques and longer survival of patients with cancer due to improvements in cancer therapy.
  • We report a 74-year-old male patient with a significant history of a high-grade urothelial carcinoma who presented with progressive back pain and concomitant weakness, grade 3-4/5 proximally and 0-1/5 distally, and distal hyperesthesia and hyperalgesia, particularly of the left lower limb.

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21764317.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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48. |......... 5%  Laveaux C, Pauchot J, Obert L, Choserot V, Tropet Y: Emergency management of traumatic collateral palmar digital nerve defect inferior to 30 mm by venous grafting. Report of 12 clinical cases. Chir Main; 2011 Feb;30(1):16-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: During the course of a monocentric retrospective study, 12 cases of emergency venous grafting were reviewed by a single independent examiner 11 months, at least, post-intervention.
  • In one of these, the bad result was also related to severe symptoms in cold conditions and a troublesome hyperesthesia.

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21071256.001).
  • [ISSN] 1769-6666
  • [Journal-full-title] Chirurgie de la main
  • [ISO-abbreviation] Chir Main
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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49. |......... 5%  Raffaeli W, Minella CE, Magnani F, Sarti D: Population-based study of central post-stroke pain in Rimini district, Italy. J Pain Res; 2013;6:705-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Population-based study of central post-stroke pain in Rimini district, Italy.
  • Central post-stroke pain (CPSP) is still an underestimated complication of stroke, resulting in impaired quality of life and, in addition to the functional and cognitive consequences of stroke, the presence of CPSP may be associated with mood disorders, such as depression, anxiety, and sleep disturbances.
  • This type of pain may also impair activities of daily living and further worsen quality of life, negatively influencing the rehabilitation process.
  • From 2008 to 2010, we selected 1,494 post-stroke patients and were able to interview 660 patients, 66 (11%) of whom reported pain with related tactile and thermal hyperesthesia, accompanied by needle puncture, tingling, swelling, and pressure sensations.
  • Despite this severe pain state, there was a high percentage of patients who did not receive adequate treatment for pain.

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  • (PMID = 24092996.001).
  • [ISSN] 1178-7090
  • [Journal-full-title] Journal of pain research
  • [ISO-abbreviation] J Pain Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3787933
  • [Keywords] NOTNLM ; central post-stroke pain / disability / stroke
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50. |......... 5%  Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, Porreca F: Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. J Med Chem; 2011 Aug 11;54(15):5562-75
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A structure-activity relationship (SAR) study led to the identification of a number of potent and selective nNOS inhibitors.
  • Compound (S)-35, with excellent potency and selectivity for nNOS, was shown to fully reverse thermal hyperalgesia when given to rats at a dose of 30 mg/kg intraperitonieally (ip) in the L5/L6 spinal nerve ligation model of neuropathic pain (Chung model).
  • In addition, this compound reduced tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in a rat model of dural inflammation relevant to migraine pain.

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  • (PMID = 21699209.001).
  • [ISSN] 1520-4804
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Quinolines; CCR50N1Z9G / 1,2,3,4-tetrahydroquinoline; EC 1.14.13.39 / NOS1 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type I
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