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1. Biomedical articles (top 50; 2010 to 2015)
1. |||||||||. 100%  Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL: Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum; 2012 Sep;64(9):2907-16
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  • [Title] Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement.
  • OBJECTIVE: The modest association between radiographic joint damage and pain in osteoarthritis (OA) has led to the suggestion of facilitated central pain processing.
  • This study evaluated the importance of ongoing tissue pathology in the maintenance of enhanced central pain processing.
  • METHODS: Pain assessment was performed on 48 patients with symptomatic knee OA and 21 sex- and age-matched pain-free healthy control subjects.
  • Pressure-pain thresholds (PPTs) were recorded using a pressure algometer (both over and distant from the knee) and a double-chamber inflatable cuff mounted around the calf.
  • Conditioned pain modulation (CPM) was assessed by recording the increase in PPT in response to experimental arm pain.
  • RESULTS: PPTs at the knee and at sites away from the knee were reduced in OA patients as compared with healthy pain-free control subjects (P < 0.0001).
  • Whereas an elevation of PPTs was noted in the healthy controls in response to experimental arm pain (P < 0.0001), no such CPM was observed in the OA patients.
  • Following joint replacement in the OA patients, there was a reduction in the widespread mechanical hyperesthesia, along with normalization of spatial summation ratios and restoration of CPM.
  • CONCLUSION: The widespread hyperesthesia and enhanced spatial summation observed in OA patients imply sensitized central pain mechanisms together with the loss of CPM.
  • Normalization of the results following joint replacement implies that these central pain processes are maintained by peripheral input.
  • [MeSH-major] Arthroplasty, Replacement, Knee. Hyperesthesia / surgery. Knee Joint / surgery. Nociceptive Pain / surgery. Osteoarthritis, Knee / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Pain Measurement. Treatment Outcome


2. ||||||||.. 76%  Wu J, Raver C, Piao C, Keller A, Faden AI: Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion. Neurotherapeutics; 2013 Jul;10(3):520-38
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  • [Title] Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.
  • Spinal cord injury (SCI) causes not only sensorimotor and cognitive deficits, but frequently also severe chronic pain that is difficult to treat (SCI pain).
  • We previously showed that hyperesthesia, as well as spontaneous pain induced by electrolytic lesions in the rat spinothalamic tract, is associated with increased spontaneous and sensory-evoked activity in the posterior thalamic nucleus (PO).
  • We have also demonstrated that rodent impact SCI increases cell cycle activation (CCA) in the injury region and that post-traumatic treatment with cyclin dependent kinase inhibitors reduces lesion volume and motor dysfunction.
  • Here we examined whether CCA contributes to neuronal hyperexcitability of PO and hyperpathia after rat contusion SCI, as well as to microglial and astroglial activation (gliopathy) that has been implicated in delayed SCI pain.
  • Trauma caused enhanced pain sensitivity, which developed weeks after injury and was correlated with increased PO neuronal activity.
  • Increased CCA was found at the thoracic spinal lesion site, the lumbar dorsal horn, and the PO.
  • Increased microglial activation and cysteine-cysteine chemokine ligand 21 expression was also observed in the PO after SCI.
  • In vivo, post-injury treatment with a selective cyclin dependent kinase inhibitor (CR8) significantly reduced cell cycle protein induction, microglial activation, and neuronal activity in the PO nucleus, as well as limiting chronic SCI-induced hyperpathia.
  • These results suggest a mechanistic role for CCA in the development of SCI pain, through effects mediated in part by the PO nucleus.
  • [MeSH-major] Cell Cycle / physiology. Gene Expression Regulation / physiology. Hyperesthesia / etiology. Hyperesthesia / pathology. Posterior Thalamic Nuclei / physiopathology. Spinal Cord Injuries / complications
  • [MeSH-minor] Action Potentials / drug effects. Animals. Cell Proliferation / drug effects. Cells, Cultured. Cyclins / pharmacology. Cyclins / therapeutic use. Disease Models, Animal. Enzyme Inhibitors / pharmacology. Exploratory Behavior / drug effects. Follow-Up Studies. Glial Fibrillary Acidic Protein / metabolism. Gliosis / drug therapy. Gliosis / etiology. Male. Microglia / chemistry. Microglia / metabolism. Microglia / pathology. Nerve Fibers, Unmyelinated / pathology. Neurons / drug effects. Pain Threshold / drug effects. Pain Threshold / physiology. Rats. Rats, Sprague-Dawley. Time Factors

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  • (PMID = 23775067.001).
  • [ISSN] 1878-7479
  • [Journal-full-title] Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
  • [ISO-abbreviation] Neurotherapeutics
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS054221; United States / NINDS NIH HHS / NS / R01 NS054221; United States / NINDS NIH HHS / NS / R01 NS066965; United States / NINDS NIH HHS / NS / R01 NS066965
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclins; 0 / Enzyme Inhibitors; 0 / Glial Fibrillary Acidic Protein
  • [Other-IDs] NLM/ PMC3701760
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3. |......... 11%  Wu J, Renn CL, Faden AI, Dorsey SG: TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways. J Neurosci; 2013 Jul 24;33(30):12447-63
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  • [Title] TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways.
  • Spinal cord injury (SCI) frequently causes severe, persistent central neuropathic pain that responds poorly to conventional pain treatments.
  • Brain-derived neurotrophic factor (BDNF) signaling appears to contribute to central sensitization and nocifensive behaviors in certain animal models of chronic pain through effects mediated in part by the alternatively spliced truncated isoform of the BDNF receptor tropomyosin-related kinase B.T1 (trkB.T1).
  • Mechanisms linking trkB.T1 to SCI-induced chronic central pain are unknown.
  • Here, we examined the role of trkB.T1 in central neuropathic pain after spinal cord contusion.
  • Genetic deletion of trkB.T1 in mice significantly reduced post-SCI mechanical hyperesthesia, locomotor dysfunction, lesion volumes, and white matter loss.
  • TGFβ-induced reactive astrocytes from WT mice showed increased cell cycle protein expression that was significantly reduced in astrocytes from trkB.T1(-/-) mice that express neither full-length trkB nor trkB.T1.
  • Administration of CR8, which selectively inhibits cyclin-dependent kinases, reduced hyperesthesia, locomotor deficits, and dorsal horn (SDH) glial changes after SCI, similar to trkB.T1 deletion, without altering trkB.T1 protein expression.
  • These data indicate that trkB.T1 contributes to the pathobiology of SCI and SCI pain through modulation of cell cycle pathways and suggest new therapeutic targets.
  • [MeSH-minor] Animals. Astrocytes / cytology. Astrocytes / physiology. Brain-Derived Neurotrophic Factor / metabolism. Cell Cycle / physiology. Hyperesthesia / genetics. Hyperesthesia / pathology. Hyperesthesia / physiopathology. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Posterior Horn Cells / physiology. Primary Cell Culture. Recovery of Function / physiology. Up-Regulation / physiology

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  • (PMID = 23884949.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NINR NIH HHS / NR / R01 NR010207; United States / NINR NIH HHS / NR / R01 NR013601; United States / NINR NIH HHS / NR / R01 NR013601; United States / NINDS NIH HHS / NS / R01 NS054221
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; EC 2.7.10.1 / Receptor, trkB
  • [Other-IDs] NLM/ PMC3721848
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4. |......... 10%  Bozynski CC, Vasquez L, O'Brien DP, Johnson GC: Compressive myelopathy associated with ectasia of the vertebral and spinal arteries in a dog. Vet Pathol; 2012 Sep;49(5):779-83
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  • A 4-year-old dog was presented for acute, progressive tetraparesis and cervical hyperesthesia.
  • [MeSH-minor] Animals. Dogs. Fibrosis / pathology. Hyperesthesia / etiology. Hyperesthesia / pathology. Hyperesthesia / veterinary. Magnetic Resonance Imaging / veterinary. Male. Neck / pathology. Radiculopathy / etiology. Radiculopathy / pathology. Radiculopathy / veterinary

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  • (PMID = 21856870.001).
  • [ISSN] 1544-2217
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. |||||||... 70%  Zhou XZ: [Hyperesthesia of back induced by cervical spondylopathy]. Zhongguo Gu Shang; 2010 Sep;23(9):722
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  • [Title] [Hyperesthesia of back induced by cervical spondylopathy].
  • [MeSH-major] Cervical Vertebrae. Hyperesthesia / etiology. Spondylosis / complications

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  • (PMID = 20964013.001).
  • [ISSN] 1003-0034
  • [Journal-full-title] Zhongguo gu shang = China journal of orthopaedics and traumatology
  • [ISO-abbreviation] Zhongguo Gu Shang
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
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6. |......... 9%  Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, Gavin AC, Bork P: Systematic identification of proteins that elicit drug side effects. Mol Syst Biol; 2013;9:663
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  • We prove this concept in vivo by confirming our prediction that activation of the serotonin 7 receptor (HTR7) is responsible for hyperesthesia in mice, which, in turn, can be prevented by a drug that selectively inhibits HTR7.
  • [MeSH-major] Hyperesthesia / genetics. Oxazolidinones / adverse effects. Pharmacogenetics. Receptors, Serotonin / metabolism. Serotonin 5-HT1 Receptor Agonists / adverse effects. Tryptamines / adverse effects

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  • (PMID = 23632385.001).
  • [ISSN] 1744-4292
  • [Journal-full-title] Molecular systems biology
  • [ISO-abbreviation] Mol. Syst. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oxazolidinones; 0 / Phenols; 0 / Receptors, Serotonin; 0 / SB 269970; 0 / Serotonin 5-HT1 Receptor Agonists; 0 / Serotonin 5-HT1 Receptor Antagonists; 0 / Sulfonamides; 0 / Tryptamines; 0 / serotonin 7 receptor; 2FS66TH3YW / zolmitriptan
  • [Other-IDs] NLM/ PMC3693830
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7. |||||||||. 120%  Wesley CK, Unger RH, Rosenberg M, Unger MA, Unger WP: Factors influencing postoperative hyperesthesia in hair restoration surgery. J Cosmet Dermatol; 2011 Dec;10(4):301-6
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  • [Title] Factors influencing postoperative hyperesthesia in hair restoration surgery.
  • We investigated the technical and demographic variables that may contribute to the frequency of postoperative hyperesthesia.
  • RESULTS:   A total of 19 patients (3.4%) reported postoperative hyperesthesia in either the donor or recipient area of their scalp.
  • Although many trends emerged, one variable significantly influenced the rate of this neurosensory symptom.
  • While no patient who had all previous and current HRS sessions performed entirely within the same investigated surgical practice (n=42) experienced postoperative hyperesthesia, 14% of our patients who underwent prior HRS by a physician outside of the investigated surgical group (n=35) developed this complication (P=0.0404).
  • The amount of intraoperative electrocautery to maintain hemostasis (P=0.0897), degree of tension upon donor wound closure (P=0.3044), and extent of donor wound edge undermining (P=0.4420) influenced the frequency of this sequela to a lesser degree.
  • CONCLUSION:   These results suggest that physicians planning repair sessions on patients who have undergone prior HRS by a physician at a different surgical center should include the specific caveat of increased incidences of postoperative hyperesthesia in their preoperative consultation.
  • [MeSH-major] Cosmetic Techniques / adverse effects. Hair Follicle / transplantation. Hyperesthesia / etiology. Scalp / surgery

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  • [Copyright] © 2011 Wiley Periodicals, Inc.
  • (PMID = 22151939.001).
  • [ISSN] 1473-2165
  • [Journal-full-title] Journal of cosmetic dermatology
  • [ISO-abbreviation] J Cosmet Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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8. |......... 9%  Stilwell G, Pissarra H: Cryptococcal meningitis in a goat--a case report. BMC Vet Res; 2014;10:84
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  • BACKGROUND: Cryptococcus spp. are saprophytic and opportunistic fungal pathogens that are known to cause severe disease in immunocompromised animals.
  • CASE PRESENTATION: The following report describes a case of a five year old buck showing severe neurological signs, including paraplegia and strong pain reaction to touch of the hindquarters region.
  • Encapsulated Cryptococcus neoformans were identified from the lungs and meninges, showing that cryptococcal meningitis should be included in the differential diagnosis of goats showing paresis and hyperesthesia.
  • CONCLUSIONS: Cryptoccocal meningitis should be included in the differential diagnosis list of goat diseases with ataxia and hyperesthesia.

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  • (PMID = 24708822.001).
  • [ISSN] 1746-6148
  • [Journal-full-title] BMC veterinary research
  • [ISO-abbreviation] BMC Vet. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4020613
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9. ||||||.... 57%  Marek I, Metzler M, Reutter G, Holter W: Recurrent fever episodes with arthralgia or hyperesthesia--have you ruled out parvovirus B19? Klin Padiatr; 2010 Nov;222(6):397-8
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  • [Title] Recurrent fever episodes with arthralgia or hyperesthesia--have you ruled out parvovirus B19?
  • [MeSH-major] Arthralgia / etiology. Erythema Infectiosum / diagnosis. Fever of Unknown Origin / etiology. Hyperesthesia / etiology. Parvovirus B19, Human

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  • (PMID = 20806168.001).
  • [ISSN] 1439-3824
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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10. |||....... 33%  Lamdhade S, Dashti R, Thussu A, Alroughani R: A young male presented with acute inguinal pain, bilateral quadriceps weakness and hyperesthesia of anterior thighs post-thrombolysis for acute myocardial infarction. Ann Saudi Med; 2014 May-Jun;34(3):265-6, 3p following 266
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  • [Title] A young male presented with acute inguinal pain, bilateral quadriceps weakness and hyperesthesia of anterior thighs post-thrombolysis for acute myocardial infarction.

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  • (PMID = 25266191.001).
  • [ISSN] 0975-4466
  • [Journal-full-title] Annals of Saudi medicine
  • [ISO-abbreviation] Ann Saudi Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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11. ||........ 15%  Tostova OO, Chestnykh EV, Iusufova MV: [Infiltration of enamel erosions as a part of combined dental care in gastroesophageal reflux disease]. Stomatologiia (Mosk); 2013;92(2):15-6
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  • [Title] [Infiltration of enamel erosions as a part of combined dental care in gastroesophageal reflux disease].
  • The paper presents the results of evaluation of clinical efficacy of the Icon infiltration method for the treatment of tooth enamel erosion associated with gastroesophageal reflux disease (GERD).
  • Twenty-seven teeth were treated, and the degree of dental hard tissues hyperesthesia reduction as well as the dynamics of erosions size was estimated.
  • It was proved that in most part of cases hyperesthesia deceased significantly and there were no increase in the erosions area during the follow-up period.
  • [MeSH-major] Dental Enamel. Gastroesophageal Reflux / complications. Hyperesthesia / drug therapy. Resins, Synthetic / therapeutic use. Tooth Erosion / drug therapy

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  • (PMID = 23715445.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii͡a
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Resins, Synthetic; 0 / icon infiltrant
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12. |......... 10%  Ait Benhaddou E, Zinebi A, Elhassani M, Raissouni L, Elhassani MR, Benomar A, Yahyaoui M: [Pachymeningitis associated with probable Horton's disease: a case report]. Rev Neurol (Paris); 2010 Feb;166(2):253-6
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  • [Title] [Pachymeningitis associated with probable Horton's disease: a case report].
  • INTRODUCTION: Horton's disease is the most common vasculitis of elder people.
  • OBSERVATION: A 71-year-old patient who presented headache, hyperesthesia of the scalp, weight loss with a biological inflammatory syndrome and meningeal thickening on MRI.
  • The diagnosis of pachymeningitis related to Horton's disease was retained.
  • CONCLUSION: Horton's disease is a potential diagnosis in elderly persons with pachymeningitis and inflammatory syndrome.
  • [MeSH-minor] Aged. Dura Mater / pathology. Female. Headache / etiology. Humans. Hyperesthesia / drug therapy. Hyperesthesia / etiology. Inflammation / pathology. Magnetic Resonance Imaging. Meninges / anatomy & histology. Meninges / drug effects. Meninges / pathology. Meningitis / etiology. Scalp / physiopathology

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  • [Copyright] Copyright 2009. Published by Elsevier Masson SAS.
  • (PMID = 19497602.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones
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13. |......... 10%  Waldinger MD, Venema PL, van Gils AP, de Lint GJ, Schweitzer DH: Stronger evidence for small fiber sensory neuropathy in restless genital syndrome: two case reports in males. J Sex Med; 2011 Jan;8(1):325-30
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  • INTRODUCTION: Restless genital syndrome (ReGS) is characterized by unwanted, unpleasant genital sensations, restless legs, and/or overactive bladder, as well as neuropathy of the dorsal nerve of the clitoris.
  • METHODS: Two males with unwanted genital sensations presented in our clinic.
  • RESULTS: ReGS in a 74-year-old male manifested as unpleasant genital sensations of being on the edge of an orgasm with overactive bladder, in the absence of erection and ejaculation.
  • Genital sensory testing elicited bilateral points of static mechanical hyperesthesia in the pudendal dermatome.
  • Manual examination of the dorsal nerve of the penis (DNP) elicited the genital sensations.
  • TENS application resulted in a 90% reduction of genital sensations and complaints of overactive bladder syndrome (OAB).
  • Genital sensory testing elicited bilateral points of static mechanical hyperesthesia in the pudendal dermatome.
  • Manual examination of the DNP elicited the genital sensations.
  • This notion and the finding of typical sensory abnormalities of the genital end branches of the pudendal nerve in males and females--as previously reported--provides strong evidence for Small Fiber Sensory Neuropathy as a common cause of ReGS.
  • [MeSH-major] Hyperesthesia. Peripheral Nervous System Diseases. Restless Legs Syndrome. Sexual Dysfunction, Physiological. Urinary Bladder, Overactive


14. |||||||||. 119%  Bulgakova AI, Islamova DM, Valeev IV, Davydova SV: [Optimization of treatment of wedge-shaped tooth defects with hyperesthesia]. Stomatologiia (Mosk); 2013;92(1):46-9
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  • [Title] [Optimization of treatment of wedge-shaped tooth defects with hyperesthesia].
  • Development of tooth wedge-shaped defect leads to a gradual loss of hard tissue and is characterized by pain.
  • Most often patients complain of pain and aesthetic defect that adversely affects the emotional status and quality of life.
  • Search for adequate means and methods of treatment providing increased resistance of dental hard tissues and reducing hyperesthesia is challenging for dentists.
  • Wedge-shaped defect and hyperesthesia as concomitant symptom was found in the city of Ufa in the 5.65 and 63.0% of dental patients, respectively.
  • [MeSH-major] Hyperesthesia / epidemiology. Hyperesthesia / therapy. Tooth Abrasion / epidemiology. Tooth Abrasion / therapy. Tooth Erosion / epidemiology. Tooth Erosion / therapy

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  • (PMID = 23528402.001).
  • [ISSN] 0039-1735
  • [Journal-full-title] Stomatologii͡a
  • [ISO-abbreviation] Stomatologiia (Mosk)
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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15. |......... 9%  Fessa CK, Lee BS: An Australian case of surfer's myelopathy. Clin J Sport Med; 2012 May;22(3):281-3
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  • We present a 19-year-old man who developed lower back pain, profound bilateral lower limb paraparesis, and hyperesthesia during his first learn to surf class.
  • [MeSH-minor] Analgesics / therapeutic use. Australia. Humans. Hyperesthesia / diagnosis. Low Back Pain / diagnosis. Low Back Pain / drug therapy. Magnetic Resonance Imaging. Male. Paraparesis / diagnosis. Paraplegia / diagnosis. Severity of Illness Index. Spinal Cord Ischemia / diagnosis. Young Adult

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  • (PMID = 22544059.001).
  • [ISSN] 1536-3724
  • [Journal-full-title] Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
  • [ISO-abbreviation] Clin J Sport Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics
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16. |......... 8%  Karmacharya P, Shah K, Pathak R, Ghimire S, Alweis R: Touch me not. J Community Hosp Intern Med Perspect; 2014;4
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  • [Title] Touch me not.
  • Central Poststroke Pain syndrome (CPSP) can occur due to disruption of the somatosensory pathways of the brain at any level such as the thalamus, medulla, or cerebral cortex.
  • It is characterized by sensory abnormalities and hyperesthesia in the part of the body correlating to the central lesion.
  • The treatment of this pain syndrome is often difficult, and it does not usually respond to traditional analgesics.

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  • (PMID = 24596647.001).
  • [ISSN] 2000-9666
  • [Journal-full-title] Journal of community hospital internal medicine perspectives
  • [ISO-abbreviation] J Community Hosp Intern Med Perspect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
  • [Other-IDs] NLM/ PMC3937561
  • [Keywords] NOTNLM ; Central Poststroke Pain / Déjerine Roussy syndrome / gabapentin / neuropathic pain / thalamic pain syndrome
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17. |......... 8%  Waldinger MD, Venema PL, van Gils AP, Schutter EM, Schweitzer DH: Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: a case report. J Sex Med; 2010 Feb;7(2 Pt 2):1029-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Females despairing of restless genital syndrome (ReGS) may request clitoridectomy for treatment of unwanted genital sensations. Aim.
  • METHODS: Following a clitoridectomy for spontaneous orgasms, a 77-year-old woman was referred to our clinic for persistent unwanted genital sensations and feelings of imminent orgasm.
  • The localizations of genital sensations were investigated by manual examination of the ramus inferior of the pubic bone (RIPB) and by sensory testing of the skin of the genital area with a cotton swab.
  • MAIN OUTCOME MEASURES: The main outcome measures included sensitivity of dorsal nerve of the clitoris in RIPB and MRI-pelvis.
  • Sensory testing of the genital area showed various points of static mechanical hyperesthesia at the left dermatome of the pudendal nerve.
  • Manual examination of the RIPB also elicited the genital sensations at the left side of the vagina at about the 3 o'clock position.
  • [MeSH-major] Circumcision, Female. Genitalia, Female / physiopathology. Sensation Disorders / etiology. Sexual Dysfunctions, Psychological / surgery
  • [MeSH-minor] Aged. Clitoris / innervation. Clitoris / pathology. Clitoris / physiopathology. Electroencephalography. Female. Humans. Hyperesthesia / surgery. Magnetic Resonance Imaging. Pubic Bone / innervation. Syndrome. Time Factors

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  • (PMID = 19912500.001).
  • [ISSN] 1743-6109
  • [Journal-full-title] The journal of sexual medicine
  • [ISO-abbreviation] J Sex Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. |......... 7%  Osgood DB, Harrington WF, Kenney EV, Harrington JF: The utility of ionotropic glutamate receptor antagonists in the treatment of nociception induced by epidural glutamate infusion in rats. Surg Neurol Int; 2013;4:106
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  • In an experimental model, elevated epidural glutamate concentrations in the lumbar spine can cause a focal hyperesthetic state.
  • RESULTS: The kainic acid antagonist, UBP 301, decreased epidural glutamate-based hyperesthesia in a dose dependent manner.
  • The N-Methyl-4-isoxazoleproionic acid (NMDA) antagonist Norketamine also significantly diminished hyperesthesia and decreased receptor expression in the dorsal horn.

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  • (PMID = 24032081.001).
  • [ISSN] 2229-5097
  • [Journal-full-title] Surgical neurology international
  • [ISO-abbreviation] Surg Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3766326
  • [Keywords] NOTNLM ; Glutamate / UBP 301 / nociception / norketamine
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19. |......... 7%  Tseng YT, Tsai HC, Sy CL, Lee SS, Wann SR, Wang YH, Chen JK, Wu KS, Chen YS: Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan. J Microbiol Immunol Infect; 2011 Oct;44(5):382-9
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  • Most of the patients presented with headache (29, 78%), fever (25, 68%), and 11(30%) had hyperesthesia.
  • Patients with hyperesthesia had longer incubation period (55 vs. 7 days, p=0.004), lower serum immunoglobulin E levels (127.5 vs. 1295 IU/mL, p<0.001), and longer duration between symptom onset and spinal taps (14 vs. 5 days, p=0.011).
  • Magnetic resonance imaging of the brain disclosed leptomeningeal enhancement (17/26, 65%) and increased signal intensity (10/26, 38%) on T2-weighted and fluid-attenuated inversion recovery images.
  • Hyperesthesia; repeated lumbar puncture in cases with lymphocytic meningitis of uncertain cause; and a detailed history, including food consumption, are important to establish an accurate diagnosis.
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Aged. Aged, 80 and over. Animals. Child. Child, Preschool. Clinical Laboratory Techniques / methods. Disease Outbreaks. Female. Humans. Male. Middle Aged. Parasitology / methods. Retrospective Studies. Taiwan / epidemiology. Young Adult

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  • [Copyright] Copyright © 2011. Published by Elsevier B.V.
  • (PMID = 21524976.001).
  • [ISSN] 1995-9133
  • [Journal-full-title] Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
  • [ISO-abbreviation] J Microbiol Immunol Infect
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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20. |......... 7%  Coradini JG, Mattjie TF, Bernardino GR, Peretti AL, Kakihata CM, Errero TK, Escher AR, Bertolini GR: Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats. Rev Bras Reumatol; 2014 Jan-Feb;54(1):7-12
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  • [Title] Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats.
  • INTRODUCTION: Both therapeutic ultrasound as a low level laser therapy are used to control musculoskeletal pain, despite controversy about its effects, yet the literature is poor and also presents conflicting results on possible cumulative effects of techniques association.
  • METHODS: 24 Wistar rats were divided into: GPL--induction of hyperesthesia in the right knee, and untreated; GUS--treated with therapeutic ultrasound (1 MHz, 0.4 W/cm2) GL--low intensity laser (830 nm, 8 J/cm2); GL+US--treated with both techniques.
  • To produce the hyperesthesia 100 μl of 5% formalin solution were injected into the tibiofemoral joint space, which was assessed by von Frey filament digital before (EV1), 15 (EV2), 30 (EV3) and 60 (EV4) minutes after induction.

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  • (PMID = 24878785.001).
  • [ISSN] 1809-4570
  • [Journal-full-title] Revista brasileira de reumatologia
  • [ISO-abbreviation] Rev Bras Reumatol
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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21. |......... 7%  Schneider AR, Chen AV, Tucker RL: Imaging diagnosis--Vertebral canal porcupine quill with presumptive secondary arachnoid diverticulum. Vet Radiol Ultrasound; 2010 Mar-Apr;51(2):152-4
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  • A 3-year-old Gordon Setter developed cervical hyperesthesia and a stiff gait.
  • At a retrospective review of the MR images, the quill appeared as a circular well-demarcated T2-hypointense lesion.

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  • (PMID = 20402400.001).
  • [ISSN] 1058-8183
  • [Journal-full-title] Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
  • [ISO-abbreviation] Vet Radiol Ultrasound
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. |......... 7%  Heij L, Dahan A, Hoitsma E: Sarcoidosis and pain caused by small-fiber neuropathy. Pain Res Treat; 2012;2012:256024
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  • [Title] Sarcoidosis and pain caused by small-fiber neuropathy.
  • Sarcoidosis is a chronic inflammatory illness and small-fiber neuropathy (SFN) is one of the disabling and often chronic manifestations of the disease.
  • SFN presents with peripheral pain and symptoms of autonomic dysfunction.
  • The character of the pain can be burning or shooting.
  • Besides, allodynia and hyperesthesia can exist.
  • The aim of treatment is often to reduce pain; however, total pain relieve is seldom achieved.

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  • (PMID = 23304492.001).
  • [ISSN] 2090-1550
  • [Journal-full-title] Pain research and treatment
  • [ISO-abbreviation] Pain Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3523152
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23. |......... 7%  Cruz-Arámbulo R, Nykamp S: Acute intraparenchymal spinal cord injury in a cat due to high-rise syndrome. Can Vet J; 2012 Mar;53(3):274-8
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  • The cat had paraplegia of the hind limbs, intact reflexes and pain perception, and hyperesthesia in the caudal thoracic area.

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  • [Cites] J Small Anim Pract. 2004 Jun;45(6):284-8 [15206472.001]
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  • (PMID = 22942443.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal. La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3280780
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24. |......... 7%  Wildgaard K, Ringsted TK, Aasvang EK, Ravn J, Werner MU, Kehlet H: Neurophysiological characterization of persistent postthoracotomy pain. Clin J Pain; 2012 Feb;28(2):136-42
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  • [Title] Neurophysiological characterization of persistent postthoracotomy pain.
  • OBJECTIVES: The postthoracotomy pain syndrome (PTPS) has a prevalence of 30% to 40%.
  • Although intraoperative nerve damage during thoracotomy has been demonstrated, it has not been clearly linked to PTPS and detailed quantitative sensory characterization data have so far not been presented, comparing PTPS and pain-free patients.
  • METHODS: Neurophysiological characterization was performed in 17 patients with PTPS and 24 pain-free postthoracotomy patients using a detailed quantitative sensory testing protocol and psychometric questionnaires.
  • RESULTS: Pain and pain-free patients had increased thresholds to tactile detection (P=0.001 and P=0.01) and cool detection (P<0.001 and P<0.01) on the operated side versus the contralateral side.
  • Pain patients also had increased thresholds for warmth detection (P<0.001) and heat pain (P<0.01) on the operated side.
  • The PTPS patients demonstrated increased side-to-side differences for warmth detection (P<0.01), heat pain (P<0.05), and cool detection (P<0.05) thresholds compared with pain-free patients.
  • Pain patients also more frequently experienced cool hyperesthesia (8 of 17 vs. 1 of 24, P<0.01), but no differences were found for pressure pain, temporal summation, or sensory mapping to cool (200 cm vs. 76 cm, P=0.18).
  • Hospital Anxiety and Depression Scale scores were higher for PTPS than for pain-free patients (P<0.01).
  • DISCUSSION: Neurophysiological assessments indicate nerve injury to be common in pain and pain-free patients after thoracotomy.
  • The combination of increased thresholds together with hyperesthesia, suggests consequences of nerve injury to be more pronounced in PTPS patients.
  • [MeSH-major] Chest Pain / diagnosis. Chest Pain / etiology. Chest Pain / physiopathology. Chronic Pain / etiology. Chronic Pain / physiopathology. Pain Measurement / methods. Thoracotomy / adverse effects
  • [MeSH-minor] Adult. Aged. Chronic Disease. Female. Humans. Male. Middle Aged

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  • (PMID = 21705872.001).
  • [ISSN] 1536-5409
  • [Journal-full-title] The Clinical journal of pain
  • [ISO-abbreviation] Clin J Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. |......... 6%  Havton LA: A lumbosacral ventral root avulsion injury and repair model for studies of neuropathic pain in rats. Methods Mol Biol; 2012;851:185-93
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  • [Title] A lumbosacral ventral root avulsion injury and repair model for studies of neuropathic pain in rats.
  • Neuropathic pain may develop after a variety of injuries to peripheral nerves and roots.
  • Recently, it has been demonstrated that injury to motor fibers in ventral roots may also result in neuropathic pain.
  • A lumbosacral ventral root avulsion injury results in acute and persistent mechanical allodynia, but not thermal hyperesthesia.
  • Interestingly, an acute replantation of the avulsed ventral roots into the spinal cord results in amelioration of the neuropathic pain.

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  • (PMID = 22351091.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / NS042719
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. |......... 6%  Ahmed Z, Powell R, Llewelyn G, Anstey A: Chronic inflammatory demyelinating polyradiculoneuropathy complicating anti TNF α therapy for chronic plaque psoriasis. BMJ Case Rep; 2011;2011
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  • A 53-year-old woman with chronic plaque psoriasis treated with adalimumab (antitumour necrosis factor (anti TNF) α therapy) for 10 months presented with an 8 week history of hyperesthesia in a 'glove and stocking' distribution and clumsiness on walking.
  • Nerve conduction studies confirmed the clinical diagnosis of a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

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  • [Cites] Muscle Nerve. 2010 May;41(5):723-7 [20405504.001]
  • [Cites] Arthritis Rheum. 2001 Sep;44(9):1977-83 [11592357.001]
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  • (PMID = 22674940.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Antibodies, Monoclonal, Humanized; 0 / Immunoglobulins, Intravenous; 0 / Tumor Necrosis Factor-alpha; FYS6T7F842 / adalimumab
  • [Other-IDs] NLM/ PMC3229329
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27. |......... 6%  Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F: 1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett; 2011 Sep 15;21(18):5234-8
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  • In general compounds with bulkier side chains displayed increased selectivity for nNOS over eNOS and iNOS isoforms.
  • One of the compounds, (R)-8 was shown to reduce tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in an in vivo rat model of dural inflammation relevant to migraine pain.

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21824773.001).
  • [ISSN] 1464-3405
  • [Journal-full-title] Bioorganic & medicinal chemistry letters
  • [ISO-abbreviation] Bioorg. Med. Chem. Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Indoles; EC 1.14.13.39 / Nitric Oxide Synthase
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28. |......... 6%  Nentwig A, Oevermann A, Burgener IA: [Doramectin intoxication in 3 kittens]. Schweiz Arch Tierheilkd; 2014 Apr;156(4):179-83
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  • Subsequently, this kitten developed behavioral changes such as aggression, hyperesthesia, tremors, and seizures and died 36 hours after presentation.

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  • (PMID = 24686818.001).
  • [ISSN] 0036-7281
  • [Journal-full-title] Schweizer Archiv für Tierheilkunde
  • [ISO-abbreviation] Schweiz. Arch. Tierheilkd.
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Switzerland
  • [Keywords] NOTNLM ; Doramectin / Ivermectin / Polioencephalomalazie / Toxizität / doramectin / epileptiforme Anfälle / ivermectin / polioencephalomalacia / seizures / toxicity
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29. |......... 6%  Kitamura Y, Sakakura N, Uchida T, Suyama M: [Neurinoma arising from brachial plexus with intrathoracic extension resected through the second intercostal space]. Kyobu Geka; 2010 Dec;63(13):1133-5
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  • The tumor was resected through the 2nd intercostal space under an axillary skin incision approach and diagnosed as neurinoma on histological examination.
  • He had a complaint of hyperesthesia of the right upper arm for 2 months postoperatively.

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  • (PMID = 21174662.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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30. |......... 6%  Johansen A, Romundstad L, Nielsen CS, Schirmer H, Stubhaug A: Persistent postsurgical pain in a general population: prevalence and predictors in the Tromsø study. Pain; 2012 Jul;153(7):1390-6
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  • [Title] Persistent postsurgical pain in a general population: prevalence and predictors in the Tromsø study.
  • Population-based data on the prevalence of persistent postsurgical pain are scarce.
  • This study aimed to assess the prevalence of persistent postsurgical pain in a general population and to describe associated physical, social, and psychological factors, including symptoms of nerve injury and sensitization.
  • A cross-sectional survey was performed in northern Norway with questionnaire items covering surgery, pain, and sensory abnormalities in the area of surgery.
  • Persistent pain in the area of surgery was reported by 40.4% of the patients (826 of 2043), moderate or severe pain by 18.3% (373 of 2043).
  • Hypoesthesia, hyperesthesia, or both was reported by 24.5% (501 of 2043).
  • There were strong associations between sensory abnormalities and persistent pain, increasingly with higher pain intensities; odds ratios were 2.68 for hypoesthesia and 6.27 for hyperesthesia.
  • Of the 826 individuals reporting persistent pain in the anatomical area of surgery, 51.0% reported chronic pain when questioned without specific reference to the surgery.
  • The present study supports evidence from clinical studies of persistent postsurgical pain, indicating a high prevalence, but reveals large discrepancies in report of pain, depending on the questions asked and the context in which the questions are presented.
  • Strong associations between sensory abnormalities and pain indicate neuropathic mechanisms in a major proportion of cases.
  • [MeSH-major] Chronic Pain / epidemiology. Pain, Postoperative / epidemiology
  • [MeSH-minor] Adult. Aged. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Norway / epidemiology. Pain Measurement. Prevalence. Questionnaires. Risk Factors

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  • [Copyright] Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
  • [CommentIn] Pain. 2012 Jul;153(7):1344-5 [22424875.001]
  • (PMID = 22445291.001).
  • [ISSN] 1872-6623
  • [Journal-full-title] Pain
  • [ISO-abbreviation] Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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31. |......... 6%  De Decker S, De Risio L, Lowrie M, Mauler D, Beltran E, Giedja A, Kenny PJ, Gielen I, Garosi L, Volk H: Cervical vertebral stenosis associated with a vertebral arch anomaly in the Basset Hound. J Vet Intern Med; 2012 Nov-Dec;26(6):1374-82
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  • OBJECTIVES: To report the clinical presentation, imaging characteristics, treatment results, and histopathological findings of a previously undescribed vertebral malformation in the Basset Hound.
  • Eighteen Basset Hounds presented for evaluation of a suspected cervical spinal cord problem.
  • Clinical signs varied from cervical hyperesthesia to nonambulatory tetraparesis.
  • CONCLUSIONS AND CLINICAL IMPORTANCE: Dorsal lamina and spinous process hypertrophy leading to ligamentum flavum hypertrophy should be included in the differential diagnosis of Basset Hounds with cervical hyperesthesia or myelopathy.

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  • [Copyright] Copyright © 2012 by the American College of Veterinary Internal Medicine.
  • (PMID = 22978330.001).
  • [ISSN] 1939-1676
  • [Journal-full-title] Journal of veterinary internal medicine / American College of Veterinary Internal Medicine
  • [ISO-abbreviation] J. Vet. Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. |......... 6%  Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credille BC, Tennent-Brown B, Cohen ND: Multicenter case-control study of signalment, diagnostic features, and outcome associated with cervical vertebral malformation-malarticulation in horses. J Am Vet Med Assoc; 2010 Oct 1;237(7):812-22
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  • Gait asymmetry and cervical hyperesthesia were frequently detected in horses with CVM.
  • CONCLUSIONS AND CLINICAL RELEVANCE: Odds of a diagnosis of CVM were greater in young horses and horses of specific breeds.
  • Detection of gait asymmetry and cervical hyperesthesia were frequently reported in association with CVM.

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  • (PMID = 20919847.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. |......... 5%  Gustorff B, Sycha T, Lieba-Samal D, Rolke R, Treede RD, Magerl W: The pattern and time course of somatosensory changes in the human UVB sunburn model reveal the presence of peripheral and central sensitization. Pain; 2013 Apr;154(4):586-97
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent nonirradiated skin were studied in 22 healthy subjects 24h after irradiation with UVB at 3-fold minimal erythema dose of a skin area 5 cm in diameter at the thigh and compared to mirror-image contralateral control areas.
  • Within the sunburn area, cold hyperesthesia (P=.01), profound generalized hyperalgesia to heat (P<.001), cold (P<.05), pinprick and pressure (P<.001), and mild dynamic mechanical allodynia (P<.001) were present.
  • The finding of cold hyperalgesia and cold hyperesthesia is new in this model.
  • These data reveal that the UVB sunburn model activates a broad spectrum of peripheral and central sensitization mechanisms and hence is a useful human surrogate model to be used as a screening tool for target engagement in phases 1 and 2a of drug development.
  • [MeSH-major] Central Nervous System Sensitization / physiology. Hyperalgesia / etiology. Pain Threshold / physiology. Sunburn / complications
  • [MeSH-minor] Adult. Analysis of Variance. Dose-Response Relationship, Radiation. Female. Humans. Laser-Doppler Flowmetry. Male. Neural Pathways / physiology. Pain Measurement. Physical Stimulation / adverse effects. Psychophysics. Skin / blood supply. Time Factors. Ultraviolet Rays / adverse effects. Vibration. Young Adult

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  • [Copyright] Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
  • (PMID = 23419598.001).
  • [ISSN] 1872-6623
  • [Journal-full-title] Pain
  • [ISO-abbreviation] Pain
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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34. |......... 5%  Bursac D, Kulas T, Persec J, Persec Z, Duić Z, Partl JZ, Glavić Z, Hrgović Z, Bojanić K: Pregnancy and vaginal delivery in epidural analgesia in woman with cerebrospinal fluid shunt. Coll Antropol; 2013 Dec;37(4):1343-5
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  • After thorough review of current literature, we came to conclusion that without absolute neurosurgical indication or acute development of listed symptoms (headaches, irritability, light sensitivity, hyperesthesia nausea, vomiting, vertigo, migraines, seizures, weakness in the arms or legs, strabismus and double vision) the best way to finish the pregnancy of woman with VP shunt is spontaneous vaginal delivery with the use of epidural analgesia, mediolateral episiotomy and vacuum extraction.

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  • (PMID = 24611354.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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35. |......... 5%  O'Brien S, Bennett D, Blair PH, Beverland DE: Femoral nerve compression after migration of bone cement to the groin after hip arthroplasty. J Arthroplasty; 2011 Dec;26(8):1571.e11-3
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  • We report the case of a 70-year-old male patient in whom an extruded cement mass migrated anteriorly and compressed the femoral nerve and impinged on the femoral artery producing acute, severe groin pain with neuralgia 9 years postoperatively.
  • Six months postoperatively, the patient's pain had resolved, but hyperesthesia of the medial thigh remained.

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21802249.001).
  • [ISSN] 1532-8406
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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36. |......... 5%  Chua NH, van Suijlekom HA, Vissers KC, Arendt-Nielsen L, Wilder-Smith OH: Differences in sensory processing between chronic cervical zygapophysial joint pain patients with and without cervicogenic headache. Cephalalgia; 2011 Jun;31(8):953-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Differences in sensory processing between chronic cervical zygapophysial joint pain patients with and without cervicogenic headache.
  • This quantitative sensory testing (QST) study systematically explores the differences in sensory pain processing in 17 CEH patients with underlying chronic cervical zygapophysial joint pain compared to 10 patients with chronic cervical zygapophysial joint pain but without CEH.
  • METHODS: The QST protocol comprises pressure pain threshold testing, thermal detection threshold testing, electrical pain threshold testing and measurement of descending inhibitory modulation using the conditioned pain modulation (CPM) paradigm.
  • RESULTS: The main difference between patients with or without CEH was the lateralization of pressure hyperalgesia to the painful side of the head of CEH patients, accompanied by cold as well as warm relative hyperesthesia on the painful side of the head and neck.
  • [MeSH-major] Pain / physiopathology. Pain Threshold / physiology. Post-Traumatic Headache / physiopathology. Somatosensory Disorders / physiopathology. Zygapophyseal Joint / physiopathology

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  • (PMID = 21571757.001).
  • [ISSN] 1468-2982
  • [Journal-full-title] Cephalalgia : an international journal of headache
  • [ISO-abbreviation] Cephalalgia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. |......... 5%  Matsumoto-Miyai K, Yamada E, Yoshizumi M, Kawatani M: The regulation of distention-induced ATP release from urothelium by the adenylyl cyclase-cyclic AMP pathway. Biomed Res; 2012 Jun;33(3):153-7
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  • An excess of urothelial ATP release was found in interstitial cystitis, a condition accompanied by hyperesthesia of the urinary bladder; it remains unclear which signals are involved in this upregulation.

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  • (PMID = 22790214.001).
  • [ISSN] 1880-313X
  • [Journal-full-title] Biomedical research (Tokyo, Japan)
  • [ISO-abbreviation] Biomed. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 8L70Q75FXE / Adenosine Triphosphate; E0399OZS9N / Cyclic AMP; EC 4.6.1.1 / Adenylate Cyclase
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38. |......... 5%  Hovaguimian A, Gibbons CH: Diagnosis and treatment of pain in small-fiber neuropathy. Curr Pain Headache Rep; 2011 Jun;15(3):193-200
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  • [Title] Diagnosis and treatment of pain in small-fiber neuropathy.
  • Small-fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, shooting pain, allodynia, and hyperesthesia.
  • Diagnosis of small-fiber neuropathy is determined primarily by the history and physical exam, but functional neurophysiologic testing and skin biopsy evaluation of intraepidermal nerve-fiber density can provide diagnostic confirmation.
  • Management of small-fiber neuropathy depends on the underlying etiology with concurrent treatment of associated neuropathic pain.
  • A variety of recent guidelines proposes the use of antidepressants, anticonvulsants, opioids, topical therapies, and nonpharmacologic treatments as part of the overall management of neuropathic pain.
  • Unfortunately, little data about the treatment of pain specifically in small-fiber neuropathy exist because most studies combine mixed neuropathic pain syndromes in the analysis.
  • Additional studies targeting the treatment of pain in small-fiber neuropathy are needed to guide decision making.
  • [MeSH-minor] Analgesics / pharmacology. Analgesics / therapeutic use. Animals. Humans. Pain / diagnosis. Pain / physiopathology. Pain Management. Peripheral Nerves / drug effects. Peripheral Nerves / physiology. Treatment Outcome

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  • [Copyright] © Springer Science+Business Media, LLC 2011
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  • (PMID = 21286866.001).
  • [ISSN] 1534-3081
  • [Journal-full-title] Current pain and headache reports
  • [ISO-abbreviation] Curr Pain Headache Rep
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K23 NS050209; United States / NINDS NIH HHS / NS / K23 NS050209; United States / NINDS NIH HHS / NS / K23 NS050209-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics
  • [Other-IDs] NLM/ NIHMS271913; NLM/ PMC3086960
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39. |......... 5%  Park MC, Kang M, Lim H, Lee IJ, Shin SJ: Mandibular tubercle resection: a means of maximizing the benefits of reduction mandibuloplasty. Plast Reconstr Surg; 2011 May;127(5):2076-82
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  • BACKGROUND: A square mandible is considered unattractive in Asia; as a result, mandibular reduction is the most common type of operation performed.
  • RESULTS: With the exception of one patient who developed hyperesthesia in the left lower lip 2 years after the procedure, all patients achieved satisfactory aesthetic results after mandibular tubercle resection and concurrent mandibular reduction.
  • CONCLUSION: The authors consider mandibular tubercle resection, either as a single procedure or combined with mandible reduction, essential for patients who require a slimmer, more feminine lower face.

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  • (PMID = 21532435.001).
  • [ISSN] 1529-4242
  • [Journal-full-title] Plastic and reconstructive surgery
  • [ISO-abbreviation] Plast. Reconstr. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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40. |......... 5%  Bernier Gosselin V, Francoz D, Babkine M, Desrochers A, Nichols S, Doré E, Bédard C, Parent J, Fairbrother JH, Fecteau G: A retrospective study of 29 cases of otitis media/interna in dairy calves. Can Vet J; 2012 Sep;53(9):957-62
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  • Clinical signs included drooping ear, ptosis, head tilt, abnormal nystagmus, strabismus, dysphagia, regurgitation, stiff neck, opisthotonos, facial hyperesthesia, and purulent aural discharge.

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  • (PMID = 23450859.001).
  • [ISSN] 0008-5286
  • [Journal-full-title] The Canadian veterinary journal. La revue vétérinaire canadienne
  • [ISO-abbreviation] Can. Vet. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents
  • [Other-IDs] NLM/ PMC3418781
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41. |......... 5%  Cornelis I, De Decker S, Gielen I, Gadeyne C, Chiers K, Vandenabeele S, Kromhout K, Van Ham LM: Idiopathic sterile inflammation of the epidural fat and epaxial muscles causing paraplegia in a mixed-breed dog. J Am Vet Med Assoc; 2013 May 15;242(10):1405-9
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  • CASE DESCRIPTION: A 4-year-old sexually intact male mixed-breed dog was evaluated because of clinical signs of acute-onset pelvic limb ataxia, rapidly progressing to paraplegia with severe spinal hyperesthesia.
  • Neurologic examination demonstrated severe spinal hyperesthesia and paraplegia with decreased nociception.
  • TREATMENT AND OUTCOME: Decompressive surgery, consisting of a continuous dorsal laminectomy, with copious lavage of the vertebral canal was performed.

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  • (PMID = 23634686.001).
  • [ISSN] 1943-569X
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. |......... 5%  Goenka A, Aziz M, Riley P, Vassallo G: Complex regional pain syndrome involving the face following snowball injury. Eur J Pediatr; 2014 Mar;173(3):397-400
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  • [Title] Complex regional pain syndrome involving the face following snowball injury.
  • Complex regional pain syndrome (CRPS) is a condition of unknown etiology characterized by autonomic, sensory, and motor disturbance.
  • The clinical characteristics were similar to those of CRPS elsewhere in the body involving burning pain, hyperalgesia, and hyperesthesia.
  • This was later accompanied by skin edema, fluctuating color, and temperature changes, as well as loss of eyebrow hair.
  • We present this patient to alert clinicians to consider CRPS in the differential diagnosis of similar cases who present with chronic facial pain and skin changes.

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  • (PMID = 24061280.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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43. |......... 5%  Weinschenk S, Brocker K, Hotz L, Strowitzki T, Joos S, HUNTER (Heidelberg University Neural Therapy Education and Research) Group: Successful therapy of vulvodynia with local anesthetics: a case report. Forsch Komplementmed; 2013;20(2):138-43
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  • BACKGROUND: Vulvodynia often occurs with unexplained vulvar pain and hyperesthesia, sexual dysfunction, and psychological disability, lacking an organic or microbiological substrate.
  • We observed a decrease in pain scores on the visual analogue scale (VAS) from initially 8-9 to presently 0-2.
  • Further studies on the underlying mechanism of injections into remote foci (interference field, stoerfeld) and the effectiveness of TLA in chronic pain syndromes should be performed.
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Injections. Pain Measurement / drug effects. Trigger Points

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  • [Copyright] Copyright © 2013 S. Karger AG, Basel.
  • (PMID = 23636033.001).
  • [ISSN] 1661-4127
  • [Journal-full-title] Forschende Komplementärmedizin (2006)
  • [ISO-abbreviation] Forsch Komplementmed
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anesthetics, Local; 4Z8Y51M438 / Procaine
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44. |......... 5%  Aslan H, Başoğlu MS, Erdoğan NK, Atasever TR, Kulduk E, Oztürkcan S, Katılmış H: Synovial sarcoma of the infratemporal fossa with intracranial extension. Kulak Burun Bogaz Ihtis Derg; 2012 Nov-Dec;22(6):348-53
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  • A 31-year-old man admitted with a one-year history of intense pain in his right jaw.
  • On physical examination, there was only hyperesthesia over the right mandible side.
  • Postoperative pathological examination reported the mass as a biphasic-type synovial sarcoma.
  • The patient who received postoperative chemoradiotherapy had no recurrent disease for one year.

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  • (PMID = 23176700.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
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45. |......... 5%  Hochberg NS, Blackburn BG, Park SY, Sejvar JJ, Effler PV, Herwaldt BL: Eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in Hawaii: clinical characteristics and potential exposures. Am J Trop Med Hyg; 2011 Oct;85(4):685-90
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  • Eighteen patients were evaluated; 94% had headache, and 65% had sensory symptoms (paresthesia, hyperesthesia, and/or numbness).
  • Three persons recalled finding a slug in their food/drink.

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  • (PMID = 21976573.001).
  • [ISSN] 1476-1645
  • [Journal-full-title] The American journal of tropical medicine and hygiene
  • [ISO-abbreviation] Am. J. Trop. Med. Hyg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3183778
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46. |......... 5%  Abdulazim A, Backhaus M, Stienen MN, Citak M, Brokinkel B, Kuhlmann T, Horch C: Intramedullary spinal cord metastasis and multiple brain metastases from urothelial carcinoma. J Clin Neurosci; 2011 Oct;18(10):1405-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, their incidence is expected to increase as a result of advances in diagnostic techniques and longer survival of patients with cancer due to improvements in cancer therapy.
  • We report a 74-year-old male patient with a significant history of a high-grade urothelial carcinoma who presented with progressive back pain and concomitant weakness, grade 3-4/5 proximally and 0-1/5 distally, and distal hyperesthesia and hyperalgesia, particularly of the left lower limb.

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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21764317.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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47. |......... 5%  Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, Porreca F: Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors. J Med Chem; 2011 Aug 11;54(15):5562-75
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  • A structure-activity relationship (SAR) study led to the identification of a number of potent and selective nNOS inhibitors.
  • Compound (S)-35, with excellent potency and selectivity for nNOS, was shown to fully reverse thermal hyperalgesia when given to rats at a dose of 30 mg/kg intraperitonieally (ip) in the L5/L6 spinal nerve ligation model of neuropathic pain (Chung model).
  • In addition, this compound reduced tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in a rat model of dural inflammation relevant to migraine pain.

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  • (PMID = 21699209.001).
  • [ISSN] 1520-4804
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Quinolines; CCR50N1Z9G / 1,2,3,4-tetrahydroquinoline; EC 1.14.13.39 / NOS1 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase Type I
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48. |......... 5%  Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA: Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J; 2013 May;27(5):1939-49
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  • Notably, peripheral inflammation significantly increased spinal eLOX3; intrathecal pretreatment with either siRNA targeting Aloxe3 or an eLOX3-selective antibody attenuated the associated allodynia.
  • These findings implicate spinal eLOX3-mediated hepoxilin synthesis in inflammatory hyperesthesia and underscore the importance of developing more selective 12-LOX/HXS inhibitors.

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  • (PMID = 23382512.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA02110; United States / NIGMS NIH HHS / GM / GM064611; United States / NIGMS NIH HHS / GM / GM069338; United States / NINDS NIH HHS / NS / NS16541; United States / NIGMS NIH HHS / GM / T32 GM007752
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 12-15-lipoxygenase; 0 / Lipoxygenase Inhibitors; EC 1.13.11.31 / Arachidonate 12-Lipoxygenase; EC 1.13.11.33 / Arachidonate 15-Lipoxygenase; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.- / hepoxilin synthase
  • [Other-IDs] NLM/ PMC3633813
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49. |......... 5%  Yanni DS, Mammis A, Ebersole K, Roonprapunt C, Sen C, Perin NI: Revision of Chiari decompression for patients with recurrent syrinx. J Clin Neurosci; 2010 Aug;17(8):1076-9
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  • The patient developed recurrent symptoms with sensory loss and hyperesthesia in the right upper extremity.
  • Re-exploration of a Chiari decompression, lysis of adhesions and revision duraplasty is an effective treatment option for recurrent syringomyelia.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20510614.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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50. |......... 5%  Hanai S, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Oya Y, Higurashi N, Hamano S: Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev; 2011 Feb;33(2):161-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient presented with fever, erythema of the entire body, and abdominal pain with vomiting.
  • Symptoms such as muscle weakness, severe hyperesthesia, dyshidrosis, and neurogenic bladder associated with autonomic disturbance developed over several days.

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  • [Copyright] Copyright © 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20395090.001).
  • [ISSN] 1872-7131
  • [Journal-full-title] Brain & development
  • [ISO-abbreviation] Brain Dev.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antibodies, Viral
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