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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||||||. 100%  Tiwari LK, Singhi S, Jayashree M, Baranwal AK, Bansal A: Hypoalbuminemia in critically sick children. Indian J Crit Care Med; 2014 Sep;18(9):565-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in critically sick children.
  • CONTEXT: There is a paucity of data evaluating serum albumin levels and outcome of critically ill-children admitted to intensive care unit (ICU).
  • AIMS: The aim was to study frequency of hypoalbuminemia and examine association between hypoalbuminemia and outcome in critically ill-children.
  • MATERIALS AND METHODS: Patients with hypoalbuminemia on admission or any time during PICU stay were compared with normoalbuminemic patients for demographic and clinical profile.
  • Effect of albumin infusion was also examined.
  • RESULTS: Hypoalbuminemia was present on admission in 21% (92 of 435) patients that increased to 34% at the end of 1(st) week and to 37% (164 of 435) during rest of the stay in PICU.
  • Though, the survivors among recipients of albumin infusion had significantly higher increase in serum albumin level (0.76 g/dL, standard deviation [SD] 0.54) compared with nonsurvivors (0.46 g/dL, SD 0.44; P = 0.016), albumin infusion did not reduce the risk of mortality.
  • CONCLUSIONS: Hypoalbuminemia is a significant indicator of mortality and morbidity in critically sick children.
  • More studies are needed to define role of albumin infusion in treatment of such patients.

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  • (PMID = 25249740.001).
  • [ISSN] 0972-5229
  • [Journal-full-title] Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
  • [ISO-abbreviation] Indian J Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4166871
  • [Keywords] NOTNLM ; Critically sick children / hypoalbuminemia / pediatric intensive care unit
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2. |||||||||. 86%  Badia Aranda E, Martín de la Torre E, Miján de la Torre A: [Protein-losing gastroenteropathy: unremembered cause of hypoalbuminemia?]. Nutr Hosp; 2011 Nov-Dec;26(6):1487-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protein-losing gastroenteropathy: unremembered cause of hypoalbuminemia?].
  • [Transliterated title] Gastroenteropatía pierde proteínas: ¿causa olvidada de hipoalbuminemia?
  • After a wide research into bibliography (MEDLINE - Pubmed),we have found few references to this gastroenteropathy as a cause of hypoalbuminemia related to malnutrition.
  • [MeSH-major] Gastrointestinal Diseases / complications. Gastrointestinal Diseases / therapy. Hypoalbuminemia / etiology. Hypoalbuminemia / therapy. Proteins / metabolism
  • [MeSH-minor] Adult. Aged, 80 and over. Azathioprine / therapeutic use. Diarrhea / etiology. Dietary Supplements. Diuretics / therapeutic use. Enteral Nutrition. Female. Humans. Hypoproteinemia / etiology. Male. Serum Albumin / analysis. Serum Albumin / metabolism. Tuberculosis, Pulmonary / complications. alpha 1-Antitrypsin / metabolism

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  • (PMID = 22411400.001).
  • [ISSN] 1699-5198
  • [Journal-full-title] Nutrición hospitalaria
  • [ISO-abbreviation] Nutr Hosp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Diuretics; 0 / Proteins; 0 / Serum Albumin; 0 / alpha 1-Antitrypsin; MRK240IY2L / Azathioprine
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3. |||||||||. 85%  Lee CS, Min IS, Hwang JH, Kwon KS, Lee HB: Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus. BMC Infect Dis; 2010;10:216
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus.
  • BACKGROUND: This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus.
  • METHODS: The patients with scrub typhus were divided into two groups based on the serum albumin levels; Group I (serum albumin <3.0 g/dL) and Group II (serum albumin >or=3.0 g/dL).
  • The outcome of patients with hypoalbuminemia was compared with that of normoalbuminemia.
  • CONCLUSIONS: This study showed hypoalbuminemia in scrub typhus was closely related to the frequency of various complication, longer hospital stay, consequently the higher medical cost, necessitating more efficient management of patients, including medical resources.
  • [MeSH-major] Hypoalbuminemia. Scrub Typhus / complications. Scrub Typhus / diagnosis

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  • (PMID = 20646323.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2919547
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4. |||||||... 72%  Chen Y, Ma WQ, Chen JM, Cai JT: Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia. World J Gastroenterol; 2010 Feb 14;16(6):782-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia.
  • A female patient with anemia and hypoalbuminemia was admitted to our hospital due to an over 20-year history of recurrent dizziness, fatigue and ankle edema.
  • [MeSH-major] Anemia / etiology. Hypoalbuminemia / etiology. Ileal Diseases / complications. Ileal Diseases / diagnosis. Ulcer / complications. Ulcer / diagnosis

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  • (PMID = 20135730.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology : WJG
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Albumins; E1UOL152H7 / Iron
  • [Other-IDs] NLM/ PMC2817070
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5. |......... 6%  Cooper IF, Siadaty MS: 'Intellectual Products' associated with 'Hypoalbuminaemia': Top Publications. BioMedLib Review; IntellectualProduct;Hypoalbuminaemia:706180743. ISSN: 2331-5717. 2014/1/23
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  • [Title] 'Intellectual Products' associated with 'Hypoalbuminaemia': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Intellectual Product' for 'hypoalbuminaemia'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Intellectual Product'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 23 publications, and group two 5055 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Therapeutic or Preventive Procedures' associated with 'Hypoalbuminaemia': Top Publications.
  • Kinugasa Y et al: A simple risk score to predict in-hospital death of elderly patients with acute decompensated heart failure--hypoalbuminemia as an additional prognostic factor.
  • Lunn PG et al: Hypoalbuminemia in energy-malnourished rats infected with Nippostrongylus brasiliensis (Nematoda).
  • Alcázar Lázaro V et al: Hypoalbuminemia and other prognostic factors of mortality at different time points after ischemic stroke.
  • González Infantino CA et al: Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding.
  • Komrokji RS et al: Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes.
  • Critselis E et al: Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support.
  • Emmrich R et al: [Hypoalbuminemias and their prognostic significance].
  • Brinson RR et al: Diarrhea in the intensive care unit: the role of hypoalbuminemia and the response to a chemically defined diet (case reports and review of the literature).
  • Wang CY et al: Higher serum C-reactive protein concentration and hypoalbuminemia are poor prognostic indicators in patients with esophageal cancer undergoing radiotherapy.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706180743.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. |||||||... 69%  Okamura K, Nagata N, Wakamatsu K, Yonemoto K, Ikegame S, Kajiki A, Takayama K, Nakanishi Y: Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis. Intern Med; 2013;52(4):439-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis.
  • The serum albumin concentrations and peripheral blood lymphocyte counts were measured on admission, and the primary outcome of interest was in-hospital death.
  • The multivariate analysis revealed that the serum albumin concentrations (OR: 0.21, 95% CI: 0.10-0.41; p<0.0001) and peripheral blood total lymphocyte counts (Category 2 [627.2-1,106.7/mm(3)] vs. 1 [<627.2/mm(3)].
  • The serum albumin concentrations and peripheral blood total lymphocyte counts were also found to be associated with in-hospital deaths directly caused by TB.
  • CONCLUSION: Hypoalbuminemia and lymphocytopenia on admission are predictive risk factors for in-hospital mortality in TB patients.
  • [MeSH-major] Hospital Mortality. Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Lymphopenia / complications. Lymphopenia / mortality. Tuberculosis / complications. Tuberculosis / mortality

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  • (PMID = 23411698.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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7. |||||||... 68%  Irie T, Kaneko Y, Nakajima T, Saito A, Kurabayashi M: QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia. Int Heart J; 2010;51(5):365-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia.
  • We report the case of a 70-year-old man presenting with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia.
  • While the serum concentrations of electrolytes were within normal ranges, serum albumin as low as 1.4 mg/dL was observed.
  • We hypothesize that hypoalbuminemia increased the free fraction of propofol, causing marked QTc prolongation and TDP.
  • [MeSH-major] Heart Conduction System / drug effects. Hypnotics and Sedatives / adverse effects. Hypoalbuminemia / physiopathology. Propofol / adverse effects. Torsades de Pointes / chemically induced. Torsades de Pointes / physiopathology

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  • (PMID = 20966611.001).
  • [ISSN] 1349-3299
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; YI7VU623SF / Propofol
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8. |||||||... 70%  Yanagimoto H, Teramatsu T, Goto J, Yanagisawa M, Harii N, Suzuki M, Hanawa T, Matsuda K, Oguchi T: [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients]. Yakugaku Zasshi; 2013;133(6):711-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients].
  • TEIC is classified as a high PBR drug (≧90%), and it was reported that the PBR of TEIC decreased with an decrease in the serum albumin level in hypoalbuminemia patients.
  • In this study, both the total concentration (Ctotal) and Cfree of TEIC were determined and the PBRs were compared between a patient with normal albumin level, hypoalbuminemia patients and CHDF patients.
  • Similarly to the previous report, the lowering of PBR of TEIC was demonstrated in the hypoalbuminemia patients.
  • On the other hand, the CHDF patients showed lower value of PBR suggesting some change in the protein binding ability, although showed higher values of serum albumin level in comparison with the hypoalbuminemia patients.
  • It was not necessary to measure the Cfree value for the hypoalbuminemia patient routinely, but the monitoring of Cfree as well as Ctotal for the CHDF patients can be important for the proper TEIC use because of the potential specialty of PBR.
  • [MeSH-major] Anti-Bacterial Agents / metabolism. Hemodiafiltration. Hypoalbuminemia / metabolism. Teicoplanin / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Drug Resistance, Bacterial. Female. Humans. Male. Methicillin-Resistant Staphylococcus aureus / drug effects. Middle Aged. Protein Binding. Serum Albumin / metabolism

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  • (PMID = 23558910.001).
  • [ISSN] 1347-5231
  • [Journal-full-title] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • [ISO-abbreviation] Yakugaku Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Serum Albumin; 61036-62-2 / Teicoplanin
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9. |||||||||. 260%  Gatta A, Verardo A, Bolognesi M: Hypoalbuminemia. Intern Emerg Med; 2012 Oct;7 Suppl 3:S193-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia.
  • Hypoalbuminemia is frequently observed in hospitalized patients and it can be associated with several different diseases, including cirrhosis, malnutrition, nephrotic syndrome and sepsis.
  • Regardless of its cause, hypoalbuminemia has a strong predictive value on mortality and morbidity.
  • Over the years, the rationale for the use of albumin has been extensively debated and the indications for human serum albumin supplementation have changed.
  • As the knowledge of the pathophysiological mechanisms of the pertinent diseases has increased, the indications for intravenous albumin supplementation have progressively decreased.
  • The purpose of this brief article is to review the causes of hypoalbuminemia and the current indications for intravenous administration of albumin.
  • Based on the available data and considering the costs, albumin supplementation should be limited to well-defined clinical scenarios and to include patients with cirrhosis and spontaneous bacterial peritonitis, patients with cirrhosis undergoing large volume paracentesis, the treatment of type 1 hepatorenal syndrome, fluid resuscitation of patients with sepsis, and therapeutic plasmapheresis with exchange of large volumes of plasma.
  • While albumin supplementation is accepted also in other clinical situations such as burns, nephrotic syndrome, hemorrhagic shock and prevention of hepatorenal syndrome, within these contexts it does not represent a first-choice treatment nor is its use supported by widely accepted guidelines.
  • [MeSH-major] Albumins / therapeutic use. Hypoalbuminemia / drug therapy

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  • (PMID = 23073857.001).
  • [ISSN] 1970-9366
  • [Journal-full-title] Internal and emergency medicine
  • [ISO-abbreviation] Intern Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Albumins
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10. |||||||||. 101%  Melinyshyn A, Callum J, Jeschke MC, Cartotto R: Albumin supplementation for hypoalbuminemia following burns: unnecessary and costly! J Burn Care Res; 2013 Jan-Feb;34(1):8-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Albumin supplementation for hypoalbuminemia following burns: unnecessary and costly!
  • Following fluid resuscitation, patients with major burns frequently develop prolonged hypoalbuminemia.
  • It is not known whether this should be corrected by albumin supplementation.
  • The purpose of this study was to determine whether there are any benefits associated with albumin supplementation to correct hypoalbuminemia in burned adults.
  • We conducted a retrospective comparison of patients with burns ≥ 20% TBSA admitted to an adult regional American Burn Association-verified burn center, from May 1, 2009, to September 30, 2010, where we did not routinely supplement albumin (control group), with patients admitted from October 1, 2010, to May 30, 2011, where we had instituted a protocol in which 5% human albumin was provided to maintain serum albumin levels >20 g/L (albumin group).
  • There were no significant differences between control (n = 26) and albumin (n = 17) in age (48 ± 15 vs 45 ± 21 years; P = .56), burn size (33 ± 13 vs 34 ± 13 %TBSA; P = .831), or full thickness burn size (19 ± 19 vs 23 ± 19 %TBSA; P = .581).
  • Inhalation injury was significantly more frequent in the albumin group than in controls (71% vs 31%; P = .01).
  • The overall mean daily serum albumin level from PB day 2 to 30 in the albumin group (26.9 ± 3.0 g/L) was significantly greater than in controls (21.9 ± 4.4 g/L; P < .001).
  • The cost of routinely supplementing 5% albumin between PB day 2 to 30 in the albumin group was more than four times that for the controls where we did not routinely provide albumin (Can $65.50 vs Can $16.57 per patient per day).
  • We conclude that routine supplementation of 5% human albumin to maintain a serum albumin level ≥ 20 g/L in burn patients is expensive and provides no benefit.
  • [MeSH-major] Albumins / therapeutic use. Burns / therapy. Hypoalbuminemia / drug therapy. Hypoalbuminemia / etiology

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  • (PMID = 23128130.001).
  • [ISSN] 1559-0488
  • [Journal-full-title] Journal of burn care & research : official publication of the American Burn Association
  • [ISO-abbreviation] J Burn Care Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins
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11. |||||||||. 100%  Battin DL, Ali S, Shahbaz AU, Massie JD, Munir A, Davis RC Jr, Newman KP, Weber KT: Hypoalbuminemia and lymphocytopenia in patients with decompensated biventricular failure. Am J Med Sci; 2010 Jan;339(1):31-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia and lymphocytopenia in patients with decompensated biventricular failure.
  • BACKGROUND: In patients hospitalized with decompensated biventricular failure having hypoalbuminemia and lymphocytopenia without underlying hepatic or renal disease, we addressed the presence of a protein-losing enteropathy (PLE).
  • METHODS: We studied 78 patients having a dilated cardiomyopathy, who were hospitalized with congestive heart failure (CHF) and hypoalbuminemia of uncertain origin.
  • In the first 19 patients, we investigated the presence of PLE using Tc-Dex scintigraphy together with serum albumin 2 to 4 weeks later when compensation had been restored.
  • In the next 59 patients, presenting with reduced serum albumin and relative lymphocyte count at admission, these parameters were again monitored (2-4 weeks) later when symptoms and signs of CHF had resolved.
  • RESULTS: PLE, documented by Tc-Dex(70) scintigraphy, was found in 10 of 19 patients and whose hypoalbuminemia (2.7 +/- 0.1 g/dL, mean +/- standard error of mean) were corrected (3.3 +/- 0.1 g/dL; P < 0.05) with the resolution of CHF, whereas in the 9 patients without a PLE, reduced baseline serum albumin (2.6 +/- 0.1 g/dL) failed to improve on follow-up (2.6 +/- 0.2 g/dL) in keeping with malnutrition.
  • Serum albumin and relative lymphocyte count were each reduced at admission (2.8 +/- 0.1 g/dL and 14.4 +/- 1.0%, respectively) in 59 patients and increased (P < 0.05) to normal values (3.5 +/- 0.1 g/dL and 24.9 +/- 1.0%) 2 to 4 weeks after they were compensated.
  • CONCLUSIONS: Enteral losses of albumin and lymphocytes account for the reversible hypoalbuminemia and lymphocytopenia found in patients hospitalized with CHF having splanchnic congestion.
  • [MeSH-major] Heart Failure / radionuclide imaging. Hypoalbuminemia / radionuclide imaging. Lymphopenia / radionuclide imaging

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  • (PMID = 20057275.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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12. |||||||||. 90%  Ñamendys-Silva SA, González-Herrera MO, Texcocano-Becerra J, Herrera-Gómez A: Hypoalbuminemia in critically ill patients with cancer: incidence and mortality. Am J Hosp Palliat Care; 2011 Jun;28(4):253-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in critically ill patients with cancer: incidence and mortality.
  • PURPOSE: The aim of this study was to investigate the incidence of hypoalbuminemia in critically ill patients with cancer and to describe the relationship of serum albumin levels to mortality.
  • A total of 164 (82%) patients had a serum albumin concentration below 35 g/L, of which 91 (55.5%) patients had levels of albumin ≤20 g/L.
  • The mean serum albumin was 18.17 g/L.
  • The highest mortality rate (73%) was seen in the group of patients whose serum albumin levels were <20 g/L.
  • CONCLUSION: The incidence of hypoalbuminemia in critically ill patients with cancer admitted to ICU was high.
  • [MeSH-major] Critical Illness. Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Intensive Care Units / statistics & numerical data. Neoplasms / complications

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  • (PMID = 21057142.001).
  • [ISSN] 1938-2715
  • [Journal-full-title] The American journal of hospice & palliative care
  • [ISO-abbreviation] Am J Hosp Palliat Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. |||||||||. 89%  Guest S: Hypoalbuminemia in peritoneal dialysis patients. Adv Perit Dial; 2013;29:55-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in peritoneal dialysis patients.
  • Traditionally, serum albumin has been an indicator of nutrition status and has therefore been included in monthly blood testing in most centers.
  • The development of hypoalbuminemia in dialysis patients has been associated with increased mortality and often leads to interventions such as trials of nutritional supplements.
  • In PD, hypoalbuminemia combined with ongoing losses of protein into effluent raise particular concerns with clinicians.
  • Serum albumin may be affected by a variety of non-nutrition factors such as inflammation, volume status, and comorbidities.
  • Albumin synthesis in the liver exceeds, in most cases, albumin losses in urine or effluent.
  • Interpreting the medical implications of declining serum albumin in PD patients can therefore be a challenge.
  • The nutritional and non-nutritional factors affecting serum albumin are discussed, with specific emphasis on how membrane physiology contributes to dialysate protein losses.
  • A general clinical approach to the PD patient developing hypoalbuminemia is discussed.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / prevention & control. Peritoneal Dialysis / adverse effects

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  • (PMID = 24344493.001).
  • [ISSN] 1197-8554
  • [Journal-full-title] Advances in peritoneal dialysis. Conference on Peritoneal Dialysis
  • [ISO-abbreviation] Adv Perit Dial
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Membranes, Artificial
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14. |||||||||. 87%  Vahedi A, Lotfinia I, Sad RB, Halimi M, Baybordi H: Relationship between admission hypoalbuminemia and inhospital mortality in acute stroke. Pak J Biol Sci; 2011 Jan 15;14(2):118-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between admission hypoalbuminemia and inhospital mortality in acute stroke.
  • This study aims at assessing the relation between hypoalbuminemia and inhospital mortality in patients with acute stroke.
  • Admission hypoalbuminemia (serum albumin < 3.5 mg dL(-) as well as other prognostic factors were determined and compared between the two groups.
  • 43% of the patients were Hypoalbuminemia.
  • Frequency of patients with admission hypoalbuminemia and is chemic heart disease was significantly higher in the nonsurvivors (75.8-32.5%, p = 0.001; 34.5 vs. 16.9%, p = 0.047, respectively).
  • In conclusion, hypoalbuminemia is an independent predictor of inhospital mortality in patients with acute stroke.
  • [MeSH-major] Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Serum Albumin / metabolism. Stroke / complications. Stroke / mortality

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  • (PMID = 21916262.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences: PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Serum Albumin
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15. ||||||||.. 84%  Verbeek L, Middeldorp JM, Hulzebos CV, Oepkes D, Walther FJ, Lopriore E: Hypoalbuminemia in donors with twin-twin transfusion syndrome. Fetal Diagn Ther; 2013;33(2):98-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in donors with twin-twin transfusion syndrome.
  • OBJECTIVE: To estimate the differences in albumin levels between donors and recipients with twin-twin transfusion syndrome (TTTS).
  • METHODS: We performed a matched case-control study including twin pairs with TTTS treated conservatively (conservative group) or with fetoscopic laser surgery (laser group) and analyzed the albumin levels at birth in donor and recipient twins.
  • Median albumin levels in donor twins in the conservative group were significantly lower than in recipient twins, 25.0 versus 33.0 g/l, respectively (p = 0.001).
  • In the laser group, albumin levels in donors and recipients were similar, 32.0 versus 32.0 g/l, respectively (p = 0.633).
  • Hypoalbuminemia (albumin level <20 g/l) occurred in 22% (4/18) of donor twins in the conservative group.
  • CONCLUSIONS: Hypoalbuminemia occurs frequently in donor twins with TTTS treated conservatively.
  • In TTTS treated with laser, donor twins have similar and normal albumin levels compared to recipients, confirming a successfully performed fetoscopic laser procedure.
  • [MeSH-major] Blood Donors. Fetofetal Transfusion / therapy. Hypoalbuminemia / blood. Iatrogenic Disease. Serum Albumin / analysis

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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 23208016.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / ALB protein, human; 0 / Serum Albumin
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16. ||||||||.. 82%  González Infantino CA, González CD, Sánchez R, Presner N: Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding. Nutrition; 2013 Mar;29(3):497-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding.
  • OBJECTIVE: To determine the association of in-hospital mortality in patients with enteral feeding to their glycemic status (normoglycemia, new hyperglycemia, or diabetes) and their levels of serum albumin.
  • At univariate analysis, in-hospital mortality was associated with age, known diabetes, newly diagnosed hyperglycemia, and albumin level.
  • Hypoalbuminemia (<2.55 g/dL) also was significantly associated with mortality (univariate odds ratio ≈2.7).
  • At multivariate analysis, in-hospital mortality was associated with age, newly diagnosed hyperglycemia, hypoalbuminemia (<2.55 g/dL), and known diabetes.
  • No interactions between hypoalbuminemia and known diabetes or newly diagnosed hyperglycemia were detected at multivariate analysis.
  • CONCLUSION: The results of this study showed that newly diagnosed hyperglycemia can be considered an independent prognostic factor of in-hospital mortality in patients with enteral feeding and that there is no interaction between newly diagnosed hyperglycemia and serum albumin levels.
  • [MeSH-major] Enteral Nutrition / mortality. Hospital Mortality. Hyperglycemia / mortality. Hypoalbuminemia / mortality

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23398919.001).
  • [ISSN] 1873-1244
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. ||||||||.. 81%  Famakin B, Weiss P, Hertzberg V, McClellan W, Presley R, Krompf K, Karp H, Frankel MR: Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry. J Stroke Cerebrovasc Dis; 2010 Jan;19(1):17-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry.
  • Univariate analysis showed that mortality was associated with older age (P = .0008), stroke type (P = .0051), Glasgow Coma Scale score less than 9 (P < .0001), decreased serum albumin (P = .0001), elevated creatinine (P = .0067), and elevated blood glucose (P = .0063).
  • In the multivariate analysis, independent risk factors for mortality after acute stroke included older age (P = .004), stroke type (P = .0007), Glasgow Coma Scale score less than 9 (P < .0001), and decreased serum albumin (P = .0003).
  • CONCLUSION: In addition to previously recognized predictors of inhospital mortality, we found hypoalbuminemia to be an independent predictor of mortality in a biracial cohort of patients with acute stroke.
  • [MeSH-major] Hypoalbuminemia / mortality. Stroke / mortality

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  • (PMID = 20123222.001).
  • [ISSN] 1532-8511
  • [Journal-full-title] Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • [ISO-abbreviation] J Stroke Cerebrovasc Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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18. ||||||||.. 79%  Vanstraelen K, Wauters J, Vercammen I, de Loor H, Maertens J, Lagrou K, Annaert P, Spriet I: Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients. Antimicrob Agents Chemother; 2014 Nov;58(11):6782-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients.
  • We investigated the impact of hypoalbuminemia (<35 g/liter) on voriconazole pharmacokinetics in adult intensive care unit (ICU) patients treated with voriconazole (20 samples in 13 patients) as well as in plasma samples from ICU patients that had been spiked with voriconazole at concentrations of 1.5 mg/liter, 2.9 mg/liter, and 9.0 mg/liter (66 samples from 22 patients).
  • Plasma albumin concentrations ranged from 13.8 to 38.7 g/liter.
  • Multivariate analysis revealed a positive relationship between voriconazole plasma protein binding and plasma albumin concentrations (P < 0.001), indicating higher unbound voriconazole concentrations with decreasing albumin concentrations.
  • We therefore propose to adjust the measured total voriconazole concentrations in patients with abnormal plasma albumin and total serum bilirubin plasma concentrations who show adverse events potentially related to voriconazole via a formula that we developed.
  • Alterations in voriconazole unbound concentrations caused by hypoalbuminemia and/or elevated bilirubin plasma concentrations cannot be countered immediately, due to the adult saturated hepatic metabolism.

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  • [Copyright] Copyright © 2014, American Society for Microbiology. All Rights Reserved.
  • (PMID = 25182655.001).
  • [ISSN] 1098-6596
  • [Journal-full-title] Antimicrobial agents and chemotherapy
  • [ISO-abbreviation] Antimicrob. Agents Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. ||||||||.. 77%  Zemlin AE, Burgess LJ, Engelbrecht A: Two cases of severe hypoalbuminemia (&lt;10 g/L). Nutrition; 2009 Oct;25(10):1006-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of severe hypoalbuminemia (<10 g/L).
  • OBJECTIVE: Hypoalbuminemia is known to occur in critically ill patients and is associated with increased mortality.
  • Severe hypoalbuminemia is defined in the literature as serum albumin levels lower than 24 g/L.
  • METHODS: Albumin levels were measured in our laboratory using the bromocresol purple method on the Synchron CX9 (Beckman Coulter); the lower detection limit on this apparatus is 10 g/L.
  • RESULTS: We report two cases of severe hypoalbuminemia with levels lower than 10 g/L-one in a complete paraplegic patient with severe pressure ulcers and the other in a patient positive for the human immunodeficiency virus with chronic renal failure.
  • CONCLUSION: Although cases of severe hypoalbuminemia (<10 g/L) are very rare in the literature, chemical pathologists should be aware of the causes of serum albumin levels of this magnitude.
  • These cases describe two different disease states that lead to severe hypoalbuminemia by means of a similar underlying cause, namely severe inflammation or infection.
  • [MeSH-major] Hypoalbuminemia / etiology
  • [MeSH-minor] Adult. Anemia / complications. Blood Protein Electrophoresis. Bromcresol Purple. Female. HIV Infections / complications. Humans. Indicators and Reagents. Male. Nephelometry and Turbidimetry. Pressure Ulcer / complications. Renal Insufficiency / complications. Serum Albumin / analysis. Spectrophotometry

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  • [CommentIn] Nutrition. 2009 Oct;25(10):1004-5 [19500943.001]
  • (PMID = 19487103.001).
  • [ISSN] 1873-1244
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indicators and Reagents; 0 / Serum Albumin; 201C22C3EC / Bromcresol Purple
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20. |||||||... 74%  Dezfuli A, Scholl D, Lindenfeld SM, Kovesdy CP, Kalantar-Zadeh K: Severity of hypoalbuminemia predicts response to intradialytic parenteral nutrition in hemodialysis patients. J Ren Nutr; 2009 Jul;19(4):291-7
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  • [Title] Severity of hypoalbuminemia predicts response to intradialytic parenteral nutrition in hemodialysis patients.
  • BACKGROUND: Intradialytic parenteral nutrition (IDPN) is used infrequently to correct hypoalbuminemia in maintenance hemodialysis (MHD) patients.
  • We hypothesized that the severity of baseline hypoalbuminemia correlates with the success rate of IDPN therapy in MHD patients.
  • RESULTS: Of 196 hypoalbuminemic MHD patients, 134 had severe hypoalbuminemia, defined as a baseline serum albumin level of less than 3.0 g/dL.
  • The baseline level of serum albumin was lower in MHD patients who responded to IDPN (2.68 +/- 0.47 g/dL, S.D.).
  • The presence of severe hypoalbuminemia (serum albumin, <3.0 g/dL) at baseline was associated with a 2.5 times higher chance of responding to IDPN (95% confidence interval, 1.3 to 4.9; P = .006).
  • The same severe hypoalbuminemia was associated with a 3.5 times increased likelihood of serum albumin correction by at least 0.5 g/dL (95% confidence interval, 1.8 to 6.8; P < .001).
  • CONCLUSIONS: Improvement of hypoalbuminemia occurs in most hypoalbuminemic MHD patients who receive IDPN therapy.
  • The likelihood and magnitude of the response to IDPN are associated with the severity of baseline hypoalbuminemia.
  • [MeSH-major] Hypoalbuminemia / therapy. Parenteral Nutrition. Renal Dialysis
  • [MeSH-minor] Aged. Female. Humans. Kidney Failure, Chronic / complications. Kidney Failure, Chronic / therapy. Logistic Models. Male. Middle Aged. Serum Albumin / analysis. Treatment Outcome

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  • (PMID = 19477140.001).
  • [ISSN] 1532-8503
  • [Journal-full-title] Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
  • [ISO-abbreviation] J Ren Nutr
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R21 DK078012; United States / NIDDK NIH HHS / DK / R21 DK078012-02
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
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21. |||||||... 73%  Eljaiek R, Dubois MJ: Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients. Burns; 2013 Feb;39(1):113-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients.
  • OBJECTIVE: Hypoalbuminemia is a common finding in burned patients, but its association with increased morbidity and mortality has not been well established.
  • We assessed whether hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in patients with severe burns.
  • A multiple linear regression analysis was conducted to assess hypoalbuminemia as an independent predictor of organ dysfunction.
  • Multiple linear regression analysis showed that hypoalbuminemia in the first 24h of admission was an independent predictor of organ dysfunction.
  • Serum albumin concentration ≤ 30 g/L was associated with a two-fold increase in organ dysfunction [SOFA scores at day 0 (p=0.005), day 1 (p=0.005) and first week mean values (p=0.004)], but not with mortality (p=0.061).
  • CONCLUSION: Hypoalbuminemia is associated with organ dysfunction in burned patients.
  • Unlike unmodifiable predictors such as age, burn surface and inhalation burn, correction of hypoalbuminemia might represent a goal for a future trial in burn patients.
  • [MeSH-major] Burns / complications. Hypoalbuminemia / etiology. Multiple Organ Failure / etiology

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  • [Copyright] Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.
  • (PMID = 22683139.001).
  • [ISSN] 1879-1409
  • [Journal-full-title] Burns : journal of the International Society for Burn Injuries
  • [ISO-abbreviation] Burns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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22. |||||||... 72%  Nagai S, Saito Y, Endo Y, Saito T, Sugai K, Ishiyama A, Komaki H, Nakagawa E, Sasaki M, Ito K, Saito Y, Sukigara S, Ito M, Goto Y, Ito S, Matsuoka K: Hypoalbuminemia in early onset dentatorubral-pallidoluysian atrophy due to leakage of albumin in multiple organs. J Neurol; 2013 May;260(5):1263-71
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  • [Title] Hypoalbuminemia in early onset dentatorubral-pallidoluysian atrophy due to leakage of albumin in multiple organs.
  • We delineate a complication of hypoalbuminemia in dentatorubral-pallidoluysian atrophy (DRPLA), which we have found to be common in this disorder.
  • Eight DRPLA patients showed hypoalbuminemia <3.5 g/dl in the initial stages of the disease (age, 2-32 years), which correlated with the CAG repeat length in each patient.
  • Disease worsened in six patients, often triggered by febrile infections and accompanied by increased urinary protein excretion.
  • One patient showed increased fecal α1-antitripsin while another showed accumulation of radioactive albumin in the urinary and gastrointestinal tracts after intravenous infusion.
  • Immunohistochemistry revealed albumin-containing monocytes and astrocytes in the perivascular areas of the cerebral white matter.
  • Immunolabeling using antibodies against the expanded polyglutamine (polyQ) polypeptide was positive in cerebral cortical neurons, hepatocytes, renal collecting ducts, and glomerular podocytes, which act as filtration barrier against serum proteins.
  • Serum albumin appears to easily leak from blood vessels in certain visceral organs in DRPLA during later stages of the illness, particularly in the kidneys of patients with largely expanded CAG repeats.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / genetics. Myoclonic Epilepsies, Progressive. Serum Albumin / metabolism

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  • (PMID = 23263592.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Nerve Tissue Proteins; 0 / Peptides; 0 / Serum Albumin; 0 / atrophin-1; 26700-71-0 / polyglutamine
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23. |||||||... 70%  Komrokji RS, Corrales-Yepez M, Kharfan-Dabaja MA, Al Ali NH, Padron E, Rollison DE, Pinilla-Ibarz J, Zhang L, Epling-Burnette PK, Lancet JE, List AF: Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes. Am J Hematol; 2012 Nov;87(11):1006-9
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  • [Title] Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes.
  • We hypothesized that hypoalbuminemia is an independent prognostic factor in patients with myelodysplastic syndromes (MDS).
  • We analyzed records of 767 patients treated at Moffitt Cancer Center between January 2001 and December 2009 to evaluate the relationship between serum albumin (SA) at the time of presentation and overall survival (OS).
  • Two-thirds of the patients had low or intermediate-1 International Prognostic Scoring System (IPSS)-based risk for MDS.
  • Median OS by SA concentration of ≤3.5, 3.6-4.0, and >4.0 g/dL was 11, 23, and 34 months, respectively (P < 0.005), whereas rate of acute myeloid leukemia progression was highest in patients with low SA (≤3.5 g/dL).
  • In multivariable analysis, SA was a significant independent co-variate for OS after adjustment for IPSS, age, serum ferritin, and transfusion dependence (hazard ratio = 0.8; 95% CI 0.6-0.9; P = 0.004).
  • Our findings indicate that hypoalbuminemia is an independent prognostic biomarker that may serve as a surrogate representative of disease biology or comorbidities in patients with MDS.
  • [MeSH-major] Hypoalbuminemia / mortality. Myelodysplastic Syndromes / mortality. Serum Albumin / analysis


24. |||||||... 69%  Frisbie JH: Anemia and hypoalbuminemia of chronic spinal cord injury: prevalence and prognostic significance. Spinal Cord; 2010 Jul;48(7):566-9
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  • [Title] Anemia and hypoalbuminemia of chronic spinal cord injury: prevalence and prognostic significance.
  • OBJECTIVE: The objective of the study was to survey a chronic spinal cord injury (SCI) population for the prevalence and prognostic significance of anemia (AN) and hypoalbuminemia (HA).
  • The number of follow-up years with AN (hematocrit <40%) or severe anemia (SAN) (hematocrit <30%) or HA (serum albumin <3 g%) was recorded for all subjects, divided between survivor and deceased subjects.
  • The fractions of survey years that were positive for SAN and/or HA among causes of death were sepsis, 42%; cancer, 33%; pulmonary failure 30%; cardiovascular disease, 25%; and undetermined causes, 9%.
  • [MeSH-major] Anemia / diagnosis. Anemia / epidemiology. Hypoalbuminemia / diagnosis. Hypoalbuminemia / epidemiology. Spinal Cord Injuries / diagnosis. Spinal Cord Injuries / epidemiology
  • [MeSH-minor] Adult. Age Factors. Chronic Disease. Cohort Studies. Female. Humans. Male. Middle Aged. Statistics as Topic

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  • (PMID = 19949419.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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25. |||||||... 69%  Bozic MA, Howenstine MS, Maguiness KM, Molleston JP: Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis. Nutr Clin Pract; 2010 Jun;25(3):304-7
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  • [Title] Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis.
  • An 8-year-old patient with cystic fibrosis presented with hypoalbuminemia as the main symptom of severe erosive esophagitis.
  • Extensive evaluation failed to reveal a nutrition, pancreatic, intestinal, or renal explanation of his hypoalbuminemia.
  • Identification and treatment of the esophagitis led to resolution of the hypoalbuminemia.
  • [MeSH-major] Cystic Fibrosis / complications. Esophagitis, Peptic / complications. Gastroesophageal Reflux / complications. Hypoalbuminemia / etiology

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  • (PMID = 20581327.001).
  • [ISSN] 1941-2452
  • [Journal-full-title] Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • [ISO-abbreviation] Nutr Clin Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. |||||||... 68%  Borda F, Borda A, Jiménez J, Zozaya JM, Prieto C, Gómez M, Urman J, Ibáñez B: [Predictive value of pre-treatment hypoalbuminemia in prognosis of resected colorectal cancer]. Gastroenterol Hepatol; 2014 May;37(5):289-95
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  • [Title] [Predictive value of pre-treatment hypoalbuminemia in prognosis of resected colorectal cancer].
  • [Transliterated title] Valor predictivo de la hipoalbuminemia pre-tratamiento sobre el pronóstico del cáncer colorrectal resecado.
  • INTRODUCTION: Albuminemia is part of the antitumoral systemic inflammatory response.
  • Univariate and multivariate analyses of survival curves were performed in patients with and without pre-treatment hypoalbuminemia (<3.5g/dl), both in the overall group of patients and in the subgroup of those with pTNM stage ii tumors.
  • In addition, we compared the 5-year tumor-related mortality in patients with and without hypoalbuminemia.
  • In the overall multivariate analysis, survival curves were better in patients with normal albumin levels than in those with hypoalbuminemia (HR=2.82; CI 95%=[1.54-5.19]; P=.001).
  • This better prognostic value of normal albumin levels was also significant in pTNM stage ii tumors: (HR=3.76; CI 95%=[1.40-10.08]; P=.009).
  • The 5-year mortality index was lower in patients with normal albumin levels: overall series=18.8% vs 42.9% (OR=3.24; CI 95%=[1.48-7.12]; p=0.001); pTNM stage ii=13.3% vs 44.4% (OR=5.2; CI 95%=[1.36-20.34]; P=0.004).
  • CONCLUSIONS: Pre-treatment hypoalbuminemia (<3.5g/dl) was independently related to shorter survival after tumor resection, both in the overall series of patients and in pTNM stage ii CRC.
  • If these results are confirmed, hypoalbuminemia would be a simple and significant marker of poor prognosis, available at the initial diagnosis.

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  • [Copyright] Copyright © 2013 Elsevier España, S.L. and AEEH y AEG. All rights reserved.
  • (PMID = 24582765.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Keywords] NOTNLM ; Albumin / Albúmina / Colorectal cancer / Cáncer colorrectal / Supervivencia / Survival
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27. |||||||... 68%  Nisar PJ, Appau KA, Remzi FH, Kiran RP: Preoperative hypoalbuminemia is associated with adverse outcomes after ileoanal pouch surgery. Inflamm Bowel Dis; 2012 Jun;18(6):1034-41
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  • [Title] Preoperative hypoalbuminemia is associated with adverse outcomes after ileoanal pouch surgery.
  • BACKGROUND: This study examines the association between preoperative albumin and ileoanal pouch (IPAA) outcomes and the utility of serum albumin in the decision to perform a staged IPAA with an initial subtotal colectomy.
  • METHODS: From 2001-2009, patients were identified from an institutional pouch database and albumin values were extracted from the clinic data repository.
  • Hypoalbuminemic (albumin <3.5 g/dL) patients were compared with patients with normal albumin.
  • Pre-IPAA hypoalbuminemia was associated with pouch failure (P = 0.004).
  • Pre-IPAA hypoalbuminemia was an independent predictor of anastomotic leak (P = 0.017).
  • Pre-IPAA hypoalbuminemia was an independent predictor of prolonged length of stay (LOS) (P < 0.001).
  • CONCLUSIONS: Preoperative serum albumin is an easily available, inexpensive marker in risk stratifying patients undergoing ileoanal pouch surgery.
  • Serum albumin may provide an objective indicator in supporting the decision to undertake a subtotal colectomy as a first step rather than total proctocolectomy with immediate pouch creation.
  • [MeSH-major] Anastomotic Leak / etiology. Colitis / surgery. Colonic Pouches / adverse effects. Hypoalbuminemia / etiology. Postoperative Complications. Proctocolectomy, Restorative
  • [MeSH-minor] Adult. Anastomosis, Surgical. Colectomy. Female. Follow-Up Studies. Humans. Length of Stay. Male. Preoperative Care. Prognosis. Prospective Studies. Quality of Life. Serum Albumin / analysis

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  • [Copyright] Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
  • (PMID = 22605611.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
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28. |||||||... 67%  Crumley AB, Stuart RC, McKernan M, McMillan DC: Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer? World J Surg; 2010 Oct;34(10):2393-8
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  • [Title] Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer?
  • BACKGROUND: Studies have indicated that hypoalbuminemia is associated with decreased survival of patients with gastric cancer.
  • However, the prognostic value of albumin may be secondary to an ongoing systemic inflammatory response.
  • The aim of the study was to assess the relation between hypoalbuminemia, the systemic inflammatory response, and survival in patients with gastric cancer.
  • METHODS: Patients diagnosed with gastric carcinoma attending the upper gastrointestinal surgical unit in the Royal Infirmary, Glasgow between April 1997 and December 2005 and who had a pretreatment measurement of albumin and C-reactive protein (CRP) were studied.
  • RESULTS: Most of the patients had stage III/IV disease and received palliative treatment.
  • On univariate analysis, stage (p < 0.001), treatment (p < 0.001), albumin level (p < 0.001), and CRP level (p < 0.001) were significant predictors of survival.
  • Albumin was no longer an independent predictor of survival.
  • CONCLUSIONS: Low albumin concentrations are associated with poorer survival in patients with gastric cancer.
  • Therefore, it appears that the relation between hypoalbuminemia and poor survival is secondary to that of the systemic inflammatory response.
  • [MeSH-major] Hypoalbuminemia / mortality. Stomach Neoplasms / blood. Stomach Neoplasms / mortality. Systemic Inflammatory Response Syndrome / mortality

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  • [CommentIn] World J Surg. 2010 Oct;34(10):2399-400 [20602100.001]
  • (PMID = 20602101.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 9007-41-4 / C-Reactive Protein
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29. |||||||... 67%  Sasatomi Y, Ito K, Abe Y, Miyake K, Ogahara S, Nakashima H, Saito T: Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. Ren Fail; 2012;34(2):189-93
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  • [Title] Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis.
  • BACKGROUND: Anemia in patients with early diabetes mellitus nephrosclerosis (DMN) is more severe than in patients with kidney disease of other origins, and the mechanism for this remains unclear.
  • We then divided the clusters with regard to renal prognosis and survival and carried out simple and multifactorial analysis of clinical data, including the body mass index, age, systolic blood pressure (BP), diastolic BP, duration after the diagnosis of diabetes mellitus, serum albumin levels, blood urea nitrogen (BUN) concentrations, serum creatinine concentrations, the estimated glomerular filtration rate (eGFR) validated in the Japanese population, iron levels, total cholesterol levels, triglyceride levels, fasting blood sugar levels, HbA1c levels, urinary protein secretion, and pathohistological parameters.
  • RESULTS: The factors that were significantly associated with the cluster group that showed severe anemia were sex (p = 0.0162), hypoalbuminemia (p < 0.0001), high BUN concentrations (p = 0.0020), low eGFR (p = 0.0104), and Kimmelstiel-Wilson nodules (p = 0.0022).
  • In addition, hypoalbuminemia (p = 0.0277), high BUN concentrations (p = 0.0338), and a low eGFR (p = 0.0417) were significantly associated with this group in a multifactorial analysis.
  • CONCLUSION: Our data strongly suggest that hypoalbuminemia is associated with severe anemia in DMN patients.
  • [MeSH-major] Anemia / etiology. Diabetic Nephropathies / complications. Hypoalbuminemia / etiology. Nephrosclerosis / complications


30. |||||||... 66%  Al Helal B, Su WS, Churchill DN, Gangji AS: Relative hypoparathyroidism and hypoalbuminemia are associated with hip fracture in hemodialysis patients. Clin Nephrol; 2010 Feb;73(2):88-93
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  • [Title] Relative hypoparathyroidism and hypoalbuminemia are associated with hip fracture in hemodialysis patients.
  • AIMS: Patients with end-stage renal disease treated by hemodialysis are at an increased risk of hip fracture.
  • RESULTS: Variables associated with hip fracture were a reduction in serum parathyroid hormone by 100 pg/ml (OR = 1.65, 95% CI 1.10, 2.46) and a decrease in serum albumin by 1 g/l (OR = 1.18, 95% CI 1.00, 1.39).
  • Median survival time in patients with hip fracture and a serum PTH value < 100 pg/ml was 17 days (95% CI 0, 37 days) as compared with 280 days (95% CI 103, 471 days) for those with a PTH value > 100 pg/ml (p < 0.02).
  • CONCLUSIONS: Relative hypoparathyroidism and hypoalbuminemia are associated with an increased risk of hip fracture in hemodialysis patients.
  • [MeSH-major] Hip Fractures / etiology. Hypoalbuminemia / complications. Hypoparathyroidism / complications. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects


31. |||||||... 66%  Kim Y, Molnar MZ, Rattanasompattikul M, Hatamizadeh P, Benner D, Kopple JD, Kovesdy CP, Kalantar-Zadeh K: Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis. Int Urol Nephrol; 2013 Feb;45(1):215-27
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  • [Title] Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis.
  • PURPOSE: Serum albumin is one of the strongest mortality predictors in maintenance hemodialysis (MHD) patients.
  • Yet, the degree to which serum albumin represents dietary protein intake or an inflammatory state, among others, is not clear.
  • We hypothesize that these inadequate protein intake and inflammation contribute somewhat equally to hypoalbuminemia.
  • METHODS: In a cross-sectional analysis, we examined correlates of low serum albumin, <3.8 g/dL, in 812 MHD patients in whom interleukin-6 (IL-6) and normalized protein nitrogen appearance (nPNA), also known as normalized protein catabolic rate (nPCR), were also measured.
  • Logistic regression estimated odds ratios were employed, and spline models were plotted to examine the likelihood of relatively low serum albumin <3.8 g/dL.
  • The baseline serum albumin, averaged over a 3-month period (mean ± SD), was 3.88 ± 0.38 g/mL.
  • The unadjusted correlation coefficients of l IL-6 and nPNA with serum albumin were -0.36 and +0.20, respectively (p < 0.001 for each comparison).
  • The likelihood for an albumin <3.8 gr/dL increased linearly with decreasing nPNA and rising serum IL-6.
  • This trend was steeper with increasing serum IL-6 up to a concentration of 30 ng/mL.
  • CONCLUSIONS: Both low protein intakes and a high state of inflammation are associated with low serum albumin in MHD patients.
  • [MeSH-major] Dietary Proteins / metabolism. Hypoalbuminemia / etiology. Inflammation / complications. Protein Deficiency / complications. Renal Dialysis
  • [MeSH-minor] Adult. Aged. C-Reactive Protein / metabolism. Creatinine / blood. Cross-Sectional Studies. Female. Humans. Interleukin-6 / blood. Logistic Models. Male. Middle Aged. Odds Ratio. Renal Insufficiency, Chronic / blood. Renal Insufficiency, Chronic / therapy. Serum Albumin / metabolism

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  • (PMID = 22528583.001).
  • [ISSN] 1573-2584
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK61162; United States / NCRR NIH HHS / RR / M01-RR00425; United States / NCATS NIH HHS / TR / UL1 TR000124
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dietary Proteins; 0 / Interleukin-6; 0 / Serum Albumin; 9007-41-4 / C-Reactive Protein; AYI8EX34EU / Creatinine
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32. |||||||... 65%  Galić G, Tomić M, Galesić K, Kvesić A, Soljić M, Mozetić V, Loncar Z, Maricić A, Martinović Z: Hypoalbuminemia and complication incidence in hemodialysed uremic patients. Coll Antropol; 2009 Jun;33(2):559-66
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  • [Title] Hypoalbuminemia and complication incidence in hemodialysed uremic patients.
  • Discussions whether hypoalbuminemia is just a marker for the malnutrition-inflammation syndrome as well as for the increased morbidity and mortality of those patients or is it an etiological factor, are becoming more and more intense.
  • In this research of the relation between hypoalbuminemia and the complications that threaten the vascular access with special reference to infection, and consequently to the life of the patients treated with chronic haemodialysis, we have chosen 120 patients with terminal renal insufficiency (ESRD) treated at the Clinical Hospital Mostar by chronic haemodialysis.
  • From the 120 (100.0%) patients, 86.8% of them had a serum albumin level below 40.0 g/L.
  • By analysing the research results of the clinical material, it has been established that in patients with serum albumin level below 40.0 g/L, the infection incidence was significantly higher than in those patients with the albumin level above 40.0 g/L (chi2 = 7.215 P = 0.0077).
  • The complication incidence is significantly higher (chi2 = 9.92 P = 0.0022) among the patients with serum albumin level below 40.0 g/L, than in those patients with higher serum level.
  • Among the patients with a serum albumin level lower than 40.0 g/L, the sepses incidence was significantly higher (chi2 = 4.77 P = 0.03), than among those patients with a serum albumin level above this value.
  • However, the difference in incidence of local infection of the vascular access between the group of patients with a serum albumin level below 40.0 g/L and those patients with albumin level above this value is not significant (chi2 = 0.65 P = 0.69).
  • [MeSH-major] Hypoalbuminemia / epidemiology. Kidney Failure, Chronic / epidemiology. Renal Dialysis. Uremia / epidemiology

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  • (PMID = 19662779.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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33. |||||||... 65%  Laodim P, Intapan PM, Sawanyawisuth K, Prasongdee TK, Laummaunwai P, Maleewong W: Hypoalbuminemia as a predictor of diarrhea caused by blastocystis hominis. Southeast Asian J Trop Med Public Health; 2013 May;44(3):374-8
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  • [Title] Hypoalbuminemia as a predictor of diarrhea caused by blastocystis hominis.
  • Only serum albumin level was significantly associated with diarrhea cases in this study with an adjusted OR of 0.162 and a 95% CI of 0.027- 0.957.
  • Hypoalbuminemia is associated with diarrhea associated with blastocystosis.
  • [MeSH-major] Blastocystis Infections / blood. Blastocystis Infections / epidemiology. Diarrhea / blood. Diarrhea / epidemiology. Hypoalbuminemia / epidemiology

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  • (PMID = 24050068.001).
  • [ISSN] 0125-1562
  • [Journal-full-title] The Southeast Asian journal of tropical medicine and public health
  • [ISO-abbreviation] Southeast Asian J. Trop. Med. Public Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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34. ||||||.... 65%  Bonilla-Palomas JL, Gámez-López AL, Moreno-Conde M, López-Ibáñez MC, Anguita-Sánchez M, Gallego de la Sacristana A, García-Catalán F, Villar-Ráez A: Hypoalbuminemia in acute heart failure patients: causes and its impact on hospital and long-term mortality. J Card Fail; 2014 May;20(5):350-8
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  • [Title] Hypoalbuminemia in acute heart failure patients: causes and its impact on hospital and long-term mortality.
  • BACKGROUND: The causes of hypoalbuminemia in patients with acute heart failure (HF) remain poorly defined, and the association between hypoalbuminemia and hospital and long-term mortality has been only partially evaluated.
  • This study sought to analyze the causes of hypoalbuminemia in acute HF patients and determine its impact on hospital and long-term mortality.
  • The patients were divided into 2 groups according to the presence or absence of hypoalbuminemia (albumin ≤3.4 g/dL), and the independent association of each variable with hypoalbuminemia and hospital mortality was assessed with the use of multiple logistic regression.
  • The association between hypoalbuminemia and long-term mortality was assessed with the use of Cox multivariate analysis.
  • In total, 108 patients (29.8%) were classified as having hypoalbuminemia.
  • Older age, higher C-reactive protein levels, and lower levels of total protein, prealbumin, transferrin, and lymphocytes were independently associated with hypoalbuminemia.
  • Hospital mortality was 8% and was independently associated with hypoalbuminemia.
  • Hypoalbuminemia was an independent predictor of mortality.
  • CONCLUSIONS: Hypoalbuminemia in acute HF patients was associated with higher hospital mortality and served as an independent predictor of long-term mortality.
  • Malnutrition and inflammation were factors causing hypoalbuminemia in this clinical setting.

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  • [Copyright] Copyright © 2014 Elsevier Inc. All rights reserved.
  • (PMID = 24486927.001).
  • [ISSN] 1532-8414
  • [Journal-full-title] Journal of cardiac failure
  • [ISO-abbreviation] J. Card. Fail.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Inflammation / congestion / malnutrition
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35. ||||||.... 64%  Anees M, Ibrahim M: Anemia and hypoalbuminemia at initiation of hemodialysis as risk factor for survival of dialysis patients. J Coll Physicians Surg Pak; 2009 Dec;19(12):776-80
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  • [Title] Anemia and hypoalbuminemia at initiation of hemodialysis as risk factor for survival of dialysis patients.
  • OBJECTIVE: To determine the survival of patients undergoing chronic maintenance hemodialysis by determining the relative risk (RR) of anemia and hypoalbuminemia at initiation of dialysis on survival.
  • METHODOLOGY: This study was conducted on all patients of end stage renal disease who presented in Accident/Emergency Department of the hospital for the first time or received calls from other departments in getting dialysis.
  • At the same time a blood sample was sent for routine hematological parameters (hemoglobin, total leucocyte count (TLC), biochemical (urea, creatinine, serum potassium and albumin) and viral markers (anti-HCV and HbsAg).
  • One hundred and sixty four patients (91.1%) were anemic (hemoglobin < 11 gm/dl) and 124 (67%) were hypoalbuminemic (serum albumin < 4 gm/dl) on first presentation.
  • On the basis of serum albumin (S.Alb), patients were divided into two groups i.e S.Alb less than 4 (3.15 + or - 0.38 gm/dl) was group 1, and more than or equal to 4 (4.23 + or - 0.28 gm/dl) was group 2, which were statistically significant (t = - 11.58, p < 0.001).
  • RR for low albumin was 1.27 and for low hemoglobin, it was 1.30.
  • Patients with very low hemoglobin and albumin are at more risk for early deaths than patients with normal hemoglobin and albumin on first presentation for dialysis.
  • [MeSH-major] Anemia / epidemiology. Hypoalbuminemia / epidemiology. Kidney Failure, Chronic / epidemiology

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  • (PMID = 20042156.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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36. ||||||.... 64%  Bleske BE, Clark MM, Wu AH, Dorsch MP: The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia. J Cardiovasc Pharmacol Ther; 2013 Jul;18(4):334-7
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  • [Title] The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia.
  • PURPOSE: Hypoalbuminemia is believed to decrease diuretic effectiveness and contribute to diuretic resistance that is observed in patients with nephrotic syndrome.
  • Hypoalbuminemia is also seen in patients with acute decompensated heart failure (ADHF).
  • However, the role of hypoalbuminemia on the effectiveness of continuous infusion diuretics in patients with ADHF is not known.
  • METHODS: To evaluate hypoalbuminemia (albumin ≤ 3 g/dL) and diuretic effectiveness, we performed a retrospective study in 162 patients admitted to a tertiary care center for treatment of ADHF over a 3-year period.
  • RESULTS: A total of 33 patients were determined to have hypoalbuminemia.
  • Average net urine output over a 2-day study period was similar between patients with and without hypoalbuminemia (-1462 ± 1734 vs -1233 ± 1560 mL, P = .46, respectively).
  • In addition, diuretic doses (furosemide equivalent/24 hours) were similar between the 2 groups (788 ± 671 vs 778 ± 713 mg, P = .91, respectively) as was baseline serum creatinine (1.6 ± 0.6 vs 1.6 ± 0.6 mg/dL, P = .5, respectively).
  • CONCLUSION: Overall, hypoalbuminemia did not decrease the diuretic effectiveness when measured by the net urine output in patients receiving continuous infusion diuretics for the treatment of ADHF.
  • [MeSH-major] Heart Failure / drug therapy. Hypoalbuminemia / drug therapy. Sodium Potassium Chloride Symporter Inhibitors / therapeutic use
  • [MeSH-minor] Acute Disease. Adult. Aged. Blood Pressure. Blood Urea Nitrogen. Bumetanide / therapeutic use. Creatinine / blood. Diuretics / therapeutic use. Female. Humans. Infusions, Intravenous / methods. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 23424098.001).
  • [ISSN] 1940-4034
  • [Journal-full-title] Journal of cardiovascular pharmacology and therapeutics
  • [ISO-abbreviation] J. Cardiovasc. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diuretics; 0 / Sodium Potassium Chloride Symporter Inhibitors; 0Y2S3XUQ5H / Bumetanide; AYI8EX34EU / Creatinine
  • [Keywords] NOTNLM ; continuous infusion / diuretics / heart failure / hypoalbuminemia
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37. ||||||.... 64%  Mizuno T, Mizokami F, Fukami K, Ito K, Shibasaki M, Nagamatsu T, Furuta K: The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia. Clin Interv Aging; 2013;8:1323-8
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  • [Title] The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia.
  • BACKGROUND: Vancomycin (VCM) treatment outcomes depend on the characteristics of the patient, and it is well known that hypoalbuminemia is a risk factor for poor treatment outcomes, as reported in a previous study.
  • However, the reason that severe hypoalbuminemia has an influence on the treatment outcome of VCM remains unknown.
  • OBJECTIVE: To elucidate the association between severe hypoalbuminemia and VCM treatment outcomes, we examined pharmacokinetic/pharmacodynamic (PK/PD) parameters in elderly patients with severe hypoalbuminemia.
  • The 94 patients were divided into severe hypoalbuminemia and non-severe hypoalbuminemia groups.
  • RESULTS: The half-life of VCM in the severe hypoalbuminemia group was significantly longer than in the non-severe hypoalbuminemia group (33.2 + 5.4 vs 24.9 + 1.6; P = 0.049).
  • Area under the concentration curve (AUC)/minimum inhibitory concentration (MIC) values of 250-450 and >450 μg × h/mL were significantly associated with 28-day mortality in the severe hypoalbuminemia group (P < 0.001), whereas AUC/MIC values of <250 μg × h/mL were not associated.
  • We also detected a significant difference in the increased percentage of nephrotoxicity in the severe hypoalbuminemia group (6 of 23 patients [26%]) compared with the non-severe hypoalbuminemia group (6 of 71 patients [8%]; P < 0.001).
  • CONCLUSION: These findings indicate that severe hypoalbuminemia influences the half-life of VCM and treatment outcomes in elderly patients (≥75 years of age).
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Cross Infection / drug therapy. Hypoalbuminemia / complications. Methicillin-Resistant Staphylococcus aureus / drug effects. Pneumonia, Bacterial / drug therapy. Vancomycin / therapeutic use

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  • [Cites] Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416 [15699079.001]
  • [Cites] Chest. 2006 Oct;130(4):947-55 [17035423.001]
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  • [Cites] Clin Infect Dis. 2008 Jun 1;46 Suppl 5:S378-85 [18462093.001]
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  • [Cites] Clin Pharmacokinet. 2011 Feb;50(2):99-110 [21142293.001]
  • (PMID = 24109180.001).
  • [ISSN] 1178-1998
  • [Journal-full-title] Clinical interventions in aging
  • [ISO-abbreviation] Clin Interv Aging
  • [Language] eng
  • [Publication-type] Journal Article; Observational Study
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 6Q205EH1VU / Vancomycin
  • [Other-IDs] NLM/ PMC3793010
  • [Keywords] NOTNLM ; elderly patients / methicillin-resistant Staphylococcus aureus / pharmacodynamics / pharmacokinetics / severe hypoalbuminemia / vancomycin
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38. ||||||.... 63%  Snyder CW, Biggio JR, Bartle DT, Georgeson KE, Muensterer OJ: Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis. Pediatr Surg Int; 2011 Nov;27(11):1155-8
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  • [Title] Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis.
  • OBJECTIVE: This study attempted to evaluate the association of early hypoalbuminemia with the risk of intestinal failure in gastroschisis patients.
  • PATIENTS AND METHODS: Neonates with gastroschisis treated at a tertiary children's hospital over a 10-year period were initially categorized into groups based on the lowest serum albumin measurement during the first 7 days of life.
  • Based on preliminary analysis, patients with serum albumin <1.5 g/dL were considered to have early severe hypoalbuminemia.
  • RESULTS: One hundred and thirty-five gastroschisis patients were included, of whom 21% had early severe hypoalbuminemia.
  • Patients with early severe hypoalbuminemia had a significantly higher risk of intestinal failure compared to those with higher albumin levels (26 vs. 8%, p = 0.015).
  • On multivariable logistic regression modeling, early severe hypoalbuminemia was strongly associated with intestinal failure (OR 6.4, 95% CI 1.8-23.3, p = 0.005).
  • CONCLUSIONS: Early severe hypoalbuminemia appears to be an independent risk factor for long-term intestinal compromise rather than merely an indicator of overall illness.
  • Further interventional studies are needed to determine whether clinical protocols utilizing judicious fluid administration, exogenous albumin, and early enteral feeding can improve clinical outcomes in gastroschisis.
  • [MeSH-major] Edema / complications. Gastroschisis / complications. Hypoalbuminemia / etiology. Ileus / complications


39. ||||||.... 62%  de la Cruz KI, Bakaeen FG, Wang XL, Huh J, LeMaire SA, Coselli JS, Chu D: Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis. Ann Thorac Surg; 2011 Mar;91(3):671-5
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  • [Title] Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis.
  • BACKGROUND: Hypoalbuminemia is associated with increased morbidity in surgical patients.
  • The impact of low albumin level on survival in cardiac surgical patients is unknown.
  • We hypothesized that a low preoperative albumin level negatively affects long-term survival after coronary artery bypass graft (CABG) surgery.
  • Propensity score analysis of 18 preoperative and intraoperative variables balanced potential confounding factors between the two groups of patients, so that the final study cohort consisted of 588 patients: 294 with a preoperative albumin level less than 3.5 g/dL (ie, hypoalbuminemia) and 294 patients with a preoperative albumin level of 3.5 g/dL or greater.
  • However, patients with hypoalbuminemia had a significantly worse 8-year survival rate (65% ± 7% versus 86% ± 3%; hazard ratio 2.2; 95% confidence interval: 1.4 to 3.6; p = 0.001) than patients without hypoalbuminemia.
  • CONCLUSIONS: Although preoperative hypoalbuminemia did not predict increased early postoperative mortality or morbidity in CABG patients, it did independently predict poor long-term survival after CABG.
  • Identifying the mechanism that underlies this relationship is essential in improving overall survival among patients with low serum albumin levels who are undergoing surgical myocardial revascularization.
  • [MeSH-major] Coronary Artery Bypass. Hypoalbuminemia / epidemiology. Serum Albumin / metabolism

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  • [Copyright] Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2011 Dec;92(6):2305; author reply 2305-6 [22115261.001]
  • [CommentIn] Ann Thorac Surg. 2011 Mar;91(3):676 [21352978.001]
  • (PMID = 21352977.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Serum Albumin
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40. ||||||.... 60%  Shioya M, Yoshida T, Kasai K, Furuya R, Kato A, Mori N, Matsumoto Y, Kumagai H: Inflammatory factors for hypoalbuminemia in Japanese peritoneal dialysis patients. Nephrology (Carlton); 2013 Aug;18(8):539-44
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  • [Title] Inflammatory factors for hypoalbuminemia in Japanese peritoneal dialysis patients.
  • AIM: Hypoalbuminaemia is a common complication of peritoneal dialysis (PD), and the leakage of albumin through peritoneal membrane may be a principal reason for hypoalbuminaemia.
  • However, the relationship between peritoneal inflammation, peritoneal transport properties and hypoalbuminaemia has not been fully elucidated.
  • METHODS: A cross-sectional study was performed on 76 Japanese PD patients who had been using a low-glucose PD solution and icodextrin.
  • Systemic inflammatory markers of C-reactive protein (CRP) and serum interleukin-6 (IL-6), peritoneal effluent markers of dialysate IL-6 and CA125, the dialysate-to-plasma ratio of creatinine (D/Pcr) and the dialysate protein concentration were measured and examined for their relationship with hypoalbuminaemia.
  • RESULTS: There was a significant positive correlation between serum IL-6 and dialysate IL-6, mean dialysate IL-6 being significantly higher than mean serum IL-6, suggesting that intraperitoneal inflammation was a principal origin of systemic inflammation.
  • Both serum and dialysate IL-6 were significantly correlated with serum albumin (r= -0.25, P<0.05 and r=-0.32, P<0.01, respectively).
  • A multiple-regression analysis showed that serum albumin was independently associated with the age, D/Pcr and serum IL-6.
  • CONCLUSION: Hypoalbuminaemia was attributable to both the increased peritoneal permeability and systemic inflammation, and intraperitoneal inflammation might contribute to developing these complications.
  • [MeSH-major] Dialysis Solutions / therapeutic use. Hypoalbuminemia / etiology. Inflammation / etiology. Inflammation Mediators / blood. Peritoneal Dialysis / adverse effects

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  • [Copyright] © 2013 The Authors. Nephrology © 2013 Asian Pacific Society of Nephrology.
  • (PMID = 23718260.001).
  • [ISSN] 1440-1797
  • [Journal-full-title] Nephrology (Carlton, Vic.)
  • [ISO-abbreviation] Nephrology (Carlton)
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biological Markers; 0 / CA-125 Antigen; 0 / Dialysis Solutions; 0 / IL6 protein, human; 0 / Inflammation Mediators; 0 / Interleukin-6; 0 / MUC16 protein, human; 0 / Membrane Proteins; 9007-41-4 / C-Reactive Protein; AYI8EX34EU / Creatinine
  • [Keywords] NOTNLM ; CA125 / dialysate / hypoalbuminaemia / inflammation / interleukin-6
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41. ||||||.... 59%  Doungngern T, Huckleberry Y, Bloom JW, Erstad B: Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia. Am J Crit Care; 2012 Jul;21(4):280-6
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  • [Title] Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia.
  • BACKGROUND: Albumin is broadly prescribed for critically ill patients although it does not have a mortality benefit over crystalloids.
  • One common use of albumin is to promote diuresis.
  • Objectives To compare urine output in patients treated with furosemide with and without albumin and to assess other variables possibly associated with enhanced diuresis.
  • METHODS: A retrospective study was conducted on patients in a medical intensive care unit who received furosemide therapy as a continuous infusion with and without 25% albumin for more than 6 hours.
  • Mean urine output in patients treated with furosemide alone did not differ significantly from output in patients treated with furo-semide plus albumin at 6, 24, and 48 hours: mean output, 1119 (SD, 597) mL vs 1201 (SD, 612) mL, P = .56; 4323 (SD, 1717) mL vs 4615 (SD, 1741) mL, P = .42; and 7563 mL (SD, 2766) vs 7432 (SD, 2324) mL, P = .94, respectively.
  • Higher concentrations of serum albumin did not improve urine output.
  • CONCLUSION: Addition of albumin to a furosemide infusion did not enhance diuresis obtained with furosemide alone in critically ill patients.
  • [MeSH-major] Diuresis / drug effects. Furosemide / administration & dosage. Hypoalbuminemia / drug therapy. Serum Albumin / administration & dosage

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  • (PMID = 22751371.001).
  • [ISSN] 1937-710X
  • [Journal-full-title] American journal of critical care : an official publication, American Association of Critical-Care Nurses
  • [ISO-abbreviation] Am. J. Crit. Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diuretics; 0 / Serum Albumin; 7LXU5N7ZO5 / Furosemide
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42. ||||||.... 59%  Lakshmi C, Srinivas CR, Paul S, Chitra TV, Kanchanamalai K, Somasundaram LS: Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin. Indian J Dermatol; 2010 Apr-Jun;55(2):181-4
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  • [Title] Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin.
  • We report the case of a patient with recurrent impetigo herpetiformis associated with diabetes mellitus, hypoalbuminemia, and hypocalcaemia; who was refractory to corticosteroids.

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  • [Cites] Arch Dermatol. 2002 Jan;138(1):128-9 [11790187.001]
  • [Cites] Clin Transplant. 2007 May-Jun;21(3):301-4 [17488376.001]
  • [Cites] Eur J Obstet Gynecol Reprod Biol. 2002 Mar 10;101(2):201-3 [11858900.001]
  • (PMID = 20606891.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2887526
  • [Keywords] NOTNLM ; Impetigo herpetiformis / cyclosporine / diabetes and hypoalbuminemia
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43. ||||||.... 58%  Safavi M, Honarmand A: The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients. Ulus Travma Acil Cerrahi Derg; 2009 Mar;15(2):120-9
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  • [Title] The impact of admission hyperglycemia or hypoalbuminemia on need ventilator, time ventilated, mortality, and morbidity in critically ill trauma patients.
  • BACKGROUND: The aim of this study was to evaluate the value of hypoalbuminemia or hyperglycemia as predictors for need ventilator and for weaning success in critically ill trauma patients.
  • The subsequent parameters were noted: serum albumin and glucose concentration, Acute Physiology and Chronic Health Evaluation III score, need ventilator, ventilator days, and fluid balance.
  • RESULTS: The initial mean serum glucose concentration was 9.3 (167.4) +/- 0.2 (3.6 mg/dl) mmol/L and the initial mean serum albumin concentration was 30.2 (3.02) +/- 0.02 (0.2 g/dl) g/L.
  • Even though the circulating albumin concentration was considerably lower and serum glucose concentration was significantly higher in ICU nonsurvivors than in ICU survivors, neither albumin (r=-0.031, p=0.23) nor blood glucose concentration (r=0.050, p=0.11) on ICU admission was a predictor of the duration of mechanical ventilation.
  • The profile of albumin and glucose concentration changes was dissimilar between weaned and mechanical ventilation-dependent patients.
  • An increase of 5 g/L (0.5 g/dl) in serum albumin concentration multiplied the relative success probability by 1.10.
  • Patients with serum albumin concentration less than 30.3 (3.03 g/dl) g/L were 1.2 times more likely to need ventilator than normo-albuminemic patients (relative risk 1.2, 95% confidence interval 1.06-1.31).
  • CONCLUSION: These results suggest that albumin and blood glucose are possible indexes of the metabolic status of the trauma patient, which could be essential in deciding the need ventilator and weanable status of the patients who are mechanically ventilated for extended periods of time.
  • [MeSH-major] Hospital Mortality. Hyperglycemia / complications. Hypoalbuminemia / complications. Intensive Care Units / statistics & numerical data. Respiration, Artificial / utilization

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  • (PMID = 19353313.001).
  • [ISSN] 1306-696X
  • [Journal-full-title] Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
  • [ISO-abbreviation] Ulus Travma Acil Cerrahi Derg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Blood Glucose
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44. ||||||.... 56%  Critselis E, Panagiotakos DB, Machairas A, Zampelas A, Critselis AN, Polychronopoulos E: Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support. Int J Food Sci Nutr; 2012 Mar;63(2):208-15
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  • [Title] Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support.
  • Postoperative hypoalbuminemia is associated with adverse outcomes, particularly in cancer patients.
  • The risk and predictors of hypoalbuminemia in cancer patients following extensive abdominal surgery (EAS), despite total parenteral nutrition (TPN) support, were evaluated.
  • EAS patients received daily TPN, including 200 mL of 5% human albumin solution.
  • Serum albumin (SA) levels and hypoalbuminemia (SA < 3.5 g/dL) were assessed daily.
  • EAS patients had an elevated risk of hypoalbuminemia during the first postoperative week [relative risk (RR): 3.12; 95% confidence interval (95% CI): 1.64-5.91].
  • Postoperative hypoalbuminemia was associated with surgery duration (RR: 1.76; 95% CI: 1.32-2.36), preoperative SA (RR: 0.24; 95% CI: 0.11-0.55), blood (RR: 1.46; 95% CI: 1.04-2.04) and Ringer's lactated solution (RR: 1.52; 95% CI: 1.12-2.07) volumes transfused intra-operatively.
  • Therefore, despite TPN, cancer patients who underwent EAS had an elevated risk of postoperative hypoalbuminemia.
  • [MeSH-major] Abdomen / surgery. Gastrointestinal Neoplasms / surgery. Hypoalbuminemia / etiology. Parenteral Nutrition, Total. Postoperative Complications. Serum Albumin / metabolism. Urogenital Neoplasms / surgery

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  • (PMID = 21939411.001).
  • [ISSN] 1465-3478
  • [Journal-full-title] International journal of food sciences and nutrition
  • [ISO-abbreviation] Int J Food Sci Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Serum Albumin
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45. ||||||.... 56%  Wiedermann CJ, Wiedermann W, Joannidis M: Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies. Intensive Care Med; 2010 Oct;36(10):1657-65
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  • [Title] Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies.
  • PURPOSE: To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI).
  • METHODS: A meta-analysis was performed of observational clinical studies evaluating the relationship between serum albumin level and the occurrence of AKI by multivariate methods.
  • Additionally, the impact was assessed of lower serum albumin on mortality in patients who developed AKI.
  • RESULTS: Seventeen clinical studies with 3,917 total patients were included: 11 studies (6 in surgical or intensive care unit patients and 5 in other hospital settings) evaluating the influence of serum albumin on AKI incidence and 6 studies describing the relationship between serum albumin and mortality among patients who had developed AKI.
  • Lower serum albumin was an independent predictor both of AKI and of death after AKI development.
  • With each 10 g L(-1) serum albumin decrement, the odds of AKI increased by 134%.
  • Among patients who had developed AKI, the odds of death rose 147% (pooled OR 2.47, 95% CI 1.51-4.05) with each 10 g L(-1) serum albumin decrement.
  • CONCLUSIONS: This meta-analysis provides evidence that hypoalbuminemia is a significant independent predictor both of AKI and of death following AKI development.
  • Serum albumin determinations may be of utility in identifying patients at increased risk for AKI or for death after AKI.
  • Controlled studies are warranted to assess interventions aimed at correcting hypoalbuminemia.
  • [MeSH-major] Acute Kidney Injury / complications. Hypoalbuminemia / complications

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  • (PMID = 20517593.001).
  • [ISSN] 1432-1238
  • [Journal-full-title] Intensive care medicine
  • [ISO-abbreviation] Intensive Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
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46. ||||||.... 55%  Tanaka T, Komasawa N, Kataiwa M, Hashimoto T, Ohue M, Minami T: [Successful use of "juzen-taiho-to", a kampo medicine, for the treatment of perioperative anemia and hypoalbuminemia]. Masui; 2014 Aug;63(8):924-6
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  • [Title] [Successful use of "juzen-taiho-to", a kampo medicine, for the treatment of perioperative anemia and hypoalbuminemia].
  • Surgery was performed under general anesthesia, and the following day, anemia (hemoglobin, 7.5 g x dl(-1)) and hypoalbuminemia (albumin, 2.7 g x dl(-1)) were observed, in addition to anorexia and general fatigue.
  • On the 18th day after admission, anemia (hemoglobin, 8.9 g x dl(-1)) and hypoalbuminemia (3.6 g x dl(-1)) improved, as did anorexia and general fatigue.
  • It is thought that the components Shimotsu-to, a component known to improve anemia, and Shikunshi-to, a vital energy supplementing component, were the main ingredients that conferred the improvements in anemia and hypoalbuminemia.
  • [MeSH-major] Anemia / drug therapy. Anesthesia, General. Drugs, Chinese Herbal / therapeutic use. Femoral Neck Fractures / surgery. Hypoalbuminemia / drug therapy. Phytotherapy. Postoperative Complications / drug therapy

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  • (PMID = 25199335.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / juzentaihoto
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47. |||||..... 54%  Baldwin MR, Arcasoy SM, Shah A, Schulze PC, Sze J, Sonett JR, Lederer DJ: Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant; 2012 May;12(5):1256-67
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  • [Title] Hypoalbuminemia and early mortality after lung transplantation: a cohort study.
  • Hypoalbuminemia predicts disability and mortality in patients with various illnesses and in the elderly.
  • The association between serum albumin concentration at the time of listing for lung transplantation and the rate of death after lung transplantation is unknown.
  • We used Cox proportional hazard models and generalized additive models to examine multivariable-adjusted associations between serum albumin and the rate of death after transplantation.
  • Those with severe (0.5-2.9 g/dL) and mild hypoalbuminemia (3.0-3.6 g/dL) had posttransplant adjusted mortality rate ratios of 1.35 (95% CI: 1.12-1.62) and 1.15 (95% CI: 1.04-1.27), respectively.
  • For each 0.5 g/dL decrease in serum albumin concentration the 1-year and overall mortality rate ratios were 1.48 (95% CI: 1.21-1.81) and 1.26 (95% CI: 1.11-1.43), respectively.
  • The association between hypoalbuminemia and posttransplant mortality was strongest in recipients with cystic fibrosis and interstitial lung disease.
  • Hypoalbuminemia is an independent risk factor for death after lung transplantation.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / mortality. Lung Transplantation / adverse effects. Lung Transplantation / mortality. Postoperative Complications. Serum Albumin / deficiency

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  • [Copyright] © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
  • [Cites] J Am Geriatr Soc. 2000 Nov;48(11):1404-7 [11083315.001]
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  • (PMID = 22335491.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K23 HL086714; United States / NHLBI NIH HHS / HL / K23HL086714; United States / NHLBI NIH HHS / HL / R01 HL103676; United States / NCRR NIH HHS / RR / UL1 RR024156
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
  • [Other-IDs] NLM/ NIHMS451807; NLM/ PMC3628840
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48. |||||..... 54%  Cheng HC, Chang WL, Chen WY, Tsai YC, Yeh YC, Sheu BS: Intravenous albumin shortens the duration of hospitalization for patients with hypoalbuminemia and bleeding peptic ulcers: a pilot study. Dig Dis Sci; 2013 Nov;58(11):3232-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravenous albumin shortens the duration of hospitalization for patients with hypoalbuminemia and bleeding peptic ulcers: a pilot study.
  • BACKGROUND: Patients with hypoalbuminemia have an increased risk of ulcer rebleeding and longer length of hospitalization.
  • AIMS: This study aimed to test whether intravenous albumin can decrease the incidence of rebleeding or shorten the duration of hospitalization in patients with bleeding peptic ulcers and hypoalbuminemia.
  • The enrolled patients were divided into a normal albumin group (serum albumin ≥ 3 g/dL, n = 39) or an intervention group (<3 g/dL, n = 23) to receive a 3-day course of omeprazole infusion and 25-day oral esomeprazole.
  • Patients (n = 29) with bleeding ulcers and hypoalbuminemia who received the same dose of intravenous and oral omeprazole but did not receive albumin therapy were enrolled from a previous study as the control group.
  • In the intervention group, patients received albumin infusion (10 g q8h) for 1 day (serum albumin levels 2.5-2.9 g/dL) and 2 days (<2.5 g/dL), respectively.
  • The risk of rebleeding developed after discharge were similar (normal albumin group vs. intervention group vs. control group, 1/5 [20 %] vs. 2/9 [22.2 %] vs. 1/11 [9.1 %], p = 0.7).
  • CONCLUSIONS: Albumin administration shortens the duration of hospitalization for patients with peptic ulcer bleeding and hypoalbuminemia, but does not decrease the incidence of rebleeding.
  • [MeSH-major] Albumins / administration & dosage. Albumins / pharmacology. Hypoalbuminemia / drug therapy. Peptic Ulcer / pathology. Peptic Ulcer Hemorrhage / drug therapy

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  • [CommentIn] Dig Dis Sci. 2014 Feb;59(2):493 [24385010.001]
  • (PMID = 23934414.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins
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49. |||||..... 53%  Braier JL, Rosso D, Latella A, Chantada G, Ozuna B, Ripoli M, Scopinaro M: Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with "risk-organ" multi-system Langerhans cell histiocytosis. J Pediatr Hematol Oncol; 2010 May;32(4):e122-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with "risk-organ" multi-system Langerhans cell histiocytosis.
  • AIM: To perform a risk factor analysis in patients with "risk organ" multi-system Langerhans cell histiocytosis at diagnosis.
  • A univariate analysis of the variables, age <2 years, lungs, spleen and hepatic involvement, presence of >or=2 risk involved organs, hypoalbuminemia and the presence of isolated anemia, anemia with thrombocytopenia with or without leukopenia at diagnosis was performed.
  • RESULTS: Fifty-six and 66 evaluable patients had hematologic and hepatic involvement at diagnosis, respectively.
  • Of all the patients, those with hypoalbuminemia had a 5-year survival of 0.16 compared with those with normal albumin levels, who had a 5-year survival of 0.65 (P<0.0001).
  • In multivariate analysis, only anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia were the independent risk factors (relative risk 3.77; confidence interval, 1.7-8.4; P<0.0011 and relative risk 2.59; confidence interval, 1.24-5.4; P<0.0112).
  • CONCLUSIONS: Anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia, were associated with worse prognosis in multi-system Langerhans cell histiocytosis.
  • Other therapeutic strategies should be considered at diagnosis or early during the initial treatment for this high risk subgroup of patients.
  • [MeSH-major] Anemia / pathology. Cell Lineage. Histiocytosis, Langerhans-Cell / diagnosis. Hypoalbuminemia / pathology. Leukopenia / pathology. Thrombocytopenia / pathology


50. |||||..... 53%  Verbeek L, Slaghekke F, Hulzebos CV, Oepkes D, Walther FJ, Lopriore E: Hypoalbuminemia in donors with twin anemia-polycythemia sequence: a matched case-control study. Fetal Diagn Ther; 2013;33(4):241-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in donors with twin anemia-polycythemia sequence: a matched case-control study.
  • OBJECTIVE: To determine the differences in albumin levels between donors and recipients with twin anemia-polycythemia sequence (TAPS).
  • We measured levels of albumin, total protein, and hemoglobin on the first day of life in donors and recipients (TAPS group) and the control group.
  • In the TAPS group, median levels (IQR) of albumin in donor twins were significantly lower than in recipient twins, i.e.
  • The median (IQR) intertwin albumin difference was significantly higher in the TAPS group than in the control group, i.e.
  • The rate of hypoalbuminemia (<20 g/l) and hypoproteinemia (<40 g/l) in donor twins with TAPS was 20% (5/25) and 32% (8/25).
  • CONCLUSIONS: In addition to lower hemoglobin levels, donor twins with TAPS also have significantly lower albumin and total protein levels compared to recipient twins.
  • [MeSH-major] Fetofetal Transfusion / physiopathology. Hypoalbuminemia / etiology. Hypoproteinemia / etiology. Polycythemia / etiology
  • [MeSH-minor] Academic Medical Centers. Birth Weight. Blood Proteins / analysis. Case-Control Studies. Female. Gestational Age. Hemoglobins / analysis. Humans. Infant, Newborn. Infant, Premature. Male. Netherlands / epidemiology. Pregnancy. Pregnancy, Twin. Retrospective Studies. Serum Albumin / analysis

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  • [Copyright] Copyright © 2013 S. Karger AG, Basel.
  • (PMID = 23485951.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / ALB protein, human; 0 / Blood Proteins; 0 / Hemoglobins; 0 / Serum Albumin
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