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1. Biomedical articles (top 50; 2010 to 2015)
1. Tiwari LK, Singhi S, Jayashree M, Baranwal AK, Bansal A: Hypoalbuminemia in critically sick children. Indian J Crit Care Med; 2014 Sep;18(9):565-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in critically sick children.
  • CONTEXT: There is a paucity of data evaluating serum albumin levels and outcome of critically ill-children admitted to intensive care unit (ICU).
  • AIMS: The aim was to study frequency of hypoalbuminemia and examine association between hypoalbuminemia and outcome in critically ill-children.
  • MATERIALS AND METHODS: Patients with hypoalbuminemia on admission or any time during PICU stay were compared with normoalbuminemic patients for demographic and clinical profile.
  • Effect of albumin infusion was also examined.
  • RESULTS: Hypoalbuminemia was present on admission in 21% (92 of 435) patients that increased to 34% at the end of 1(st) week and to 37% (164 of 435) during rest of the stay in PICU.
  • Though, the survivors among recipients of albumin infusion had significantly higher increase in serum albumin level (0.76 g/dL, standard deviation [SD] 0.54) compared with nonsurvivors (0.46 g/dL, SD 0.44; P = 0.016), albumin infusion did not reduce the risk of mortality.
  • CONCLUSIONS: Hypoalbuminemia is a significant indicator of mortality and morbidity in critically sick children.
  • More studies are needed to define role of albumin infusion in treatment of such patients.

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  • (PMID = 25249740.001).
  • [ISSN] 0972-5229
  • [Journal-full-title] Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
  • [ISO-abbreviation] Indian J Crit Care Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4166871
  • [Keywords] NOTNLM ; Critically sick children / hypoalbuminemia / pediatric intensive care unit
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2. Badia Aranda E, Martín de la Torre E, Miján de la Torre A: [Protein-losing gastroenteropathy: unremembered cause of hypoalbuminemia?]. Nutr Hosp; 2011 Nov-Dec;26(6):1487-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Protein-losing gastroenteropathy: unremembered cause of hypoalbuminemia?].
  • [Transliterated title] Gastroenteropatía pierde proteínas: ¿causa olvidada de hipoalbuminemia?
  • After a wide research into bibliography (MEDLINE - Pubmed),we have found few references to this gastroenteropathy as a cause of hypoalbuminemia related to malnutrition.
  • [MeSH-major] Gastrointestinal Diseases / complications. Gastrointestinal Diseases / therapy. Hypoalbuminemia / etiology. Hypoalbuminemia / therapy. Proteins / metabolism
  • [MeSH-minor] Adult. Aged, 80 and over. Azathioprine / therapeutic use. Diarrhea / etiology. Dietary Supplements. Diuretics / therapeutic use. Enteral Nutrition. Female. Humans. Hypoproteinemia / etiology. Male. Serum Albumin / analysis. Serum Albumin / metabolism. Tuberculosis, Pulmonary / complications. alpha 1-Antitrypsin / metabolism

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  • (PMID = 22411400.001).
  • [ISSN] 1699-5198
  • [Journal-full-title] Nutrición hospitalaria
  • [ISO-abbreviation] Nutr Hosp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Diuretics; 0 / Proteins; 0 / Serum Albumin; 0 / alpha 1-Antitrypsin; MRK240IY2L / Azathioprine
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3. Vanstraelen K, Wauters J, Vercammen I, de Loor H, Maertens J, Lagrou K, Annaert P, Spriet I: Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients. Antimicrob Agents Chemother; 2014 Nov;58(11):6782-9
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  • [Title] Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients.
  • We investigated the impact of hypoalbuminemia (<35 g/liter) on voriconazole pharmacokinetics in adult intensive care unit (ICU) patients treated with voriconazole (20 samples in 13 patients) as well as in plasma samples from ICU patients that had been spiked with voriconazole at concentrations of 1.5 mg/liter, 2.9 mg/liter, and 9.0 mg/liter (66 samples from 22 patients).
  • Plasma albumin concentrations ranged from 13.8 to 38.7 g/liter.
  • Multivariate analysis revealed a positive relationship between voriconazole plasma protein binding and plasma albumin concentrations (P < 0.001), indicating higher unbound voriconazole concentrations with decreasing albumin concentrations.
  • We therefore propose to adjust the measured total voriconazole concentrations in patients with abnormal plasma albumin and total serum bilirubin plasma concentrations who show adverse events potentially related to voriconazole via a formula that we developed.
  • Alterations in voriconazole unbound concentrations caused by hypoalbuminemia and/or elevated bilirubin plasma concentrations cannot be countered immediately, due to the adult saturated hepatic metabolism.

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  • [Copyright] Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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  • (PMID = 25182655.001).
  • [ISSN] 1098-6596
  • [Journal-full-title] Antimicrobial agents and chemotherapy
  • [ISO-abbreviation] Antimicrob. Agents Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4249353
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4. de Castro LL, de Carvalho e Martins Mdo C, Garcez AM, Pacheco JF, Cunha FV, Moita Neto JM, de Freitas MC, de Melo Cunha LA: Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program. Nutr Hosp; 2014;30(4):952-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia and oxidative stress in patients on renal hemodialysis program.
  • INTRODUCTION: Albumin is considered an important extracellular antioxidant molecule. hypoalbuminemia is a strong and independent predictor of mortality in patients on hemodialysis.
  • The present study evaluated the relation between hypoalbuminemia and oxidative stress by comparing superoxide dismutase activity, lipid peroxidation and antioxidant micronutrient consumption in chronic renal failure patients.
  • The patients with hypoalbuminemia (ALB < 3,5 g/dL) were defined as case (n = 26) and control (n = 38) those with ALB ≥ 3.5 g/dL.Determinations of activity superoxide dismutase (SOD)and nitric oxide production by the contraction of nitrite in erythrocytes, concentration of malondialdehyde (MDA)in plasma, lipid profile and micronutrient antioxidants intake were performed.
  • RESULTS: Consumption of copper was significantly lower(p < 0.05) in the group with hypoalbuminemia.
  • There was a positive correlation between the concentrations of albumin and intake copper (r = 0.280).
  • Negative correlation was found between albumin and MDA concentrations.
  • CONCLUSION: Hypoalbuminemia is associated with increased lipid peroxidation, and can contribute to oxidative stress in chronic renal failure patients.
  • Additionally, patients with chronic renal disease undergoing hemodialysis evaluated in this study had reduced consumption of cooper.

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  • [Copyright] Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
  • (PMID = 25335687.001).
  • [ISSN] 1699-5198
  • [Journal-full-title] Nutrición hospitalaria
  • [ISO-abbreviation] Nutr Hosp
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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5. Gatta A, Verardo A, Bolognesi M: Hypoalbuminemia. Intern Emerg Med; 2012 Oct;7 Suppl 3:S193-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia.
  • Hypoalbuminemia is frequently observed in hospitalized patients and it can be associated with several different diseases, including cirrhosis, malnutrition, nephrotic syndrome and sepsis.
  • Regardless of its cause, hypoalbuminemia has a strong predictive value on mortality and morbidity.
  • Over the years, the rationale for the use of albumin has been extensively debated and the indications for human serum albumin supplementation have changed.
  • As the knowledge of the pathophysiological mechanisms of the pertinent diseases has increased, the indications for intravenous albumin supplementation have progressively decreased.
  • The purpose of this brief article is to review the causes of hypoalbuminemia and the current indications for intravenous administration of albumin.
  • Based on the available data and considering the costs, albumin supplementation should be limited to well-defined clinical scenarios and to include patients with cirrhosis and spontaneous bacterial peritonitis, patients with cirrhosis undergoing large volume paracentesis, the treatment of type 1 hepatorenal syndrome, fluid resuscitation of patients with sepsis, and therapeutic plasmapheresis with exchange of large volumes of plasma.
  • While albumin supplementation is accepted also in other clinical situations such as burns, nephrotic syndrome, hemorrhagic shock and prevention of hepatorenal syndrome, within these contexts it does not represent a first-choice treatment nor is its use supported by widely accepted guidelines.
  • [MeSH-major] Albumins / therapeutic use. Hypoalbuminemia / drug therapy

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  • (PMID = 23073857.001).
  • [ISSN] 1970-9366
  • [Journal-full-title] Internal and emergency medicine
  • [ISO-abbreviation] Intern Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Albumins
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6. Irie T, Kaneko Y, Nakajima T, Saito A, Kurabayashi M: QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia. Int Heart J; 2010;51(5):365-6
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  • [Title] QT interval prolongation and torsade de pointes induced by propofol and hypoalbuminemia.
  • We report the case of a 70-year-old man presenting with the development of torsade de pointes (TDP) during infusion of propofol in the setting of severe hypoalbuminemia.
  • While the serum concentrations of electrolytes were within normal ranges, serum albumin as low as 1.4 mg/dL was observed.
  • We hypothesize that hypoalbuminemia increased the free fraction of propofol, causing marked QTc prolongation and TDP.
  • [MeSH-major] Heart Conduction System / drug effects. Hypnotics and Sedatives / adverse effects. Hypoalbuminemia / physiopathology. Propofol / adverse effects. Torsades de Pointes / chemically induced. Torsades de Pointes / physiopathology

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  • (PMID = 20966611.001).
  • [ISSN] 1349-3299
  • [Journal-full-title] International heart journal
  • [ISO-abbreviation] Int Heart J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hypnotics and Sedatives; YI7VU623SF / Propofol
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7. Cooper IF, Siadaty MS: 'Patient or Disabled Groups' associated with 'Hypoalbuminaemia': Top Publications. BioMedLib Review; PatientOrDisabled;Hypoalbuminaemia:707104732. ISSN: 2331-5717. 2014/1/5
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  • [Title] 'Patient or Disabled Groups' associated with 'Hypoalbuminaemia': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Patient or Disabled Group' for 'hypoalbuminaemia'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Patient or Disabled Group'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 25 publications, and group two 664 publications.
  • Here are the top 10.
  • Okamura K et al: Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis.
  • Yanagimoto H et al: [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients].
  • Yu Z et al: Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients.
  • Mizuno T et al: The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia.
  • Ionescu D et al: Pre-operative hypoalbuminemia in colorectal cancer patients undergoing elective surgery - a major risk factor for postoperative outcome.
  • Doungngern T et al: Effect of albumin on diuretic response to furosemide in patients with hypoalbuminemia.
  • Guest S: Hypoalbuminemia in peritoneal dialysis patients.
  • Eljaiek R et al: Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients.
  • Sasatomi Y et al: Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis.
  • Bleske BE et al: The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707104732.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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8. Yanagimoto H, Teramatsu T, Goto J, Yanagisawa M, Harii N, Suzuki M, Hanawa T, Matsuda K, Oguchi T: [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients]. Yakugaku Zasshi; 2013;133(6):711-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Specific variability of teicoplanin protein binding in patients receiving continuous hemodiafiltration-comparison with hypoalbuminemia patients].
  • TEIC is classified as a high PBR drug (≧90%), and it was reported that the PBR of TEIC decreased with an decrease in the serum albumin level in hypoalbuminemia patients.
  • An antibiotic activity is directly determined by the level of unbound antibiotics species (Cfree) in the target site, namely, an increase in the Cfree enhances the risks of TEIC as well as the therapeutic effect against Methicillin-resistant Staphylococcus aureus (MRSA).
  • In this study, both the total concentration (Ctotal) and Cfree of TEIC were determined and the PBRs were compared between a patient with normal albumin level, hypoalbuminemia patients and CHDF patients.
  • Similarly to the previous report, the lowering of PBR of TEIC was demonstrated in the hypoalbuminemia patients.
  • On the other hand, the CHDF patients showed lower value of PBR suggesting some change in the protein binding ability, although showed higher values of serum albumin level in comparison with the hypoalbuminemia patients.
  • It was not necessary to measure the Cfree value for the hypoalbuminemia patient routinely, but the monitoring of Cfree as well as Ctotal for the CHDF patients can be important for the proper TEIC use because of the potential specialty of PBR.
  • [MeSH-major] Anti-Bacterial Agents / metabolism. Hemodiafiltration. Hypoalbuminemia / metabolism. Teicoplanin / metabolism
  • [MeSH-minor] Aged. Aged, 80 and over. Drug Resistance, Bacterial. Female. Humans. Male. Methicillin-Resistant Staphylococcus aureus / drug effects. Middle Aged. Protein Binding. Serum Albumin / metabolism

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  • (PMID = 23558910.001).
  • [ISSN] 1347-5231
  • [Journal-full-title] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • [ISO-abbreviation] Yakugaku Zasshi
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Serum Albumin; 61036-62-2 / Teicoplanin
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9. Battin DL, Ali S, Shahbaz AU, Massie JD, Munir A, Davis RC Jr, Newman KP, Weber KT: Hypoalbuminemia and lymphocytopenia in patients with decompensated biventricular failure. Am J Med Sci; 2010 Jan;339(1):31-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia and lymphocytopenia in patients with decompensated biventricular failure.
  • BACKGROUND: In patients hospitalized with decompensated biventricular failure having hypoalbuminemia and lymphocytopenia without underlying hepatic or renal disease, we addressed the presence of a protein-losing enteropathy (PLE).
  • METHODS: We studied 78 patients having a dilated cardiomyopathy, who were hospitalized with congestive heart failure (CHF) and hypoalbuminemia of uncertain origin.
  • In the first 19 patients, we investigated the presence of PLE using Tc-Dex scintigraphy together with serum albumin 2 to 4 weeks later when compensation had been restored.
  • In the next 59 patients, presenting with reduced serum albumin and relative lymphocyte count at admission, these parameters were again monitored (2-4 weeks) later when symptoms and signs of CHF had resolved.
  • RESULTS: PLE, documented by Tc-Dex(70) scintigraphy, was found in 10 of 19 patients and whose hypoalbuminemia (2.7 +/- 0.1 g/dL, mean +/- standard error of mean) were corrected (3.3 +/- 0.1 g/dL; P < 0.05) with the resolution of CHF, whereas in the 9 patients without a PLE, reduced baseline serum albumin (2.6 +/- 0.1 g/dL) failed to improve on follow-up (2.6 +/- 0.2 g/dL) in keeping with malnutrition.
  • Relative lymphocyte count was reduced (14.6 +/- 1.5%) in patients with PLE but was normal (21.4 +/- 3.3%; P < 0.05) in those without PLE.
  • Serum albumin and relative lymphocyte count were each reduced at admission (2.8 +/- 0.1 g/dL and 14.4 +/- 1.0%, respectively) in 59 patients and increased (P < 0.05) to normal values (3.5 +/- 0.1 g/dL and 24.9 +/- 1.0%) 2 to 4 weeks after they were compensated.
  • CONCLUSIONS: Enteral losses of albumin and lymphocytes account for the reversible hypoalbuminemia and lymphocytopenia found in patients hospitalized with CHF having splanchnic congestion.
  • [MeSH-major] Heart Failure / radionuclide imaging. Hypoalbuminemia / radionuclide imaging. Lymphopenia / radionuclide imaging

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  • (PMID = 20057275.001).
  • [ISSN] 1538-2990
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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10. Melinyshyn A, Callum J, Jeschke MC, Cartotto R: Albumin supplementation for hypoalbuminemia following burns: unnecessary and costly! J Burn Care Res; 2013 Jan-Feb;34(1):8-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Albumin supplementation for hypoalbuminemia following burns: unnecessary and costly!
  • Following fluid resuscitation, patients with major burns frequently develop prolonged hypoalbuminemia.
  • It is not known whether this should be corrected by albumin supplementation.
  • The purpose of this study was to determine whether there are any benefits associated with albumin supplementation to correct hypoalbuminemia in burned adults.
  • We conducted a retrospective comparison of patients with burns ≥ 20% TBSA admitted to an adult regional American Burn Association-verified burn center, from May 1, 2009, to September 30, 2010, where we did not routinely supplement albumin (control group), with patients admitted from October 1, 2010, to May 30, 2011, where we had instituted a protocol in which 5% human albumin was provided to maintain serum albumin levels >20 g/L (albumin group).
  • There were no significant differences between control (n = 26) and albumin (n = 17) in age (48 ± 15 vs 45 ± 21 years; P = .56), burn size (33 ± 13 vs 34 ± 13 %TBSA; P = .831), or full thickness burn size (19 ± 19 vs 23 ± 19 %TBSA; P = .581).
  • Inhalation injury was significantly more frequent in the albumin group than in controls (71% vs 31%; P = .01).
  • The overall mean daily serum albumin level from PB day 2 to 30 in the albumin group (26.9 ± 3.0 g/L) was significantly greater than in controls (21.9 ± 4.4 g/L; P < .001).
  • The cost of routinely supplementing 5% albumin between PB day 2 to 30 in the albumin group was more than four times that for the controls where we did not routinely provide albumin (Can $65.50 vs Can $16.57 per patient per day).
  • We conclude that routine supplementation of 5% human albumin to maintain a serum albumin level ≥ 20 g/L in burn patients is expensive and provides no benefit.
  • [MeSH-major] Albumins / therapeutic use. Burns / therapy. Hypoalbuminemia / drug therapy. Hypoalbuminemia / etiology

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  • (PMID = 23128130.001).
  • [ISSN] 1559-0488
  • [Journal-full-title] Journal of burn care & research : official publication of the American Burn Association
  • [ISO-abbreviation] J Burn Care Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins
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11. Ñamendys-Silva SA, González-Herrera MO, Texcocano-Becerra J, Herrera-Gómez A: Hypoalbuminemia in critically ill patients with cancer: incidence and mortality. Am J Hosp Palliat Care; 2011 Jun;28(4):253-7
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  • [Title] Hypoalbuminemia in critically ill patients with cancer: incidence and mortality.
  • PURPOSE: The aim of this study was to investigate the incidence of hypoalbuminemia in critically ill patients with cancer and to describe the relationship of serum albumin levels to mortality.
  • A total of 164 (82%) patients had a serum albumin concentration below 35 g/L, of which 91 (55.5%) patients had levels of albumin ≤20 g/L.
  • The mean serum albumin was 18.17 g/L.
  • The highest mortality rate (73%) was seen in the group of patients whose serum albumin levels were <20 g/L.
  • CONCLUSION: The incidence of hypoalbuminemia in critically ill patients with cancer admitted to ICU was high.
  • [MeSH-major] Critical Illness. Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Intensive Care Units / statistics & numerical data. Neoplasms / complications

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  • (PMID = 21057142.001).
  • [ISSN] 1938-2715
  • [Journal-full-title] The American journal of hospice & palliative care
  • [ISO-abbreviation] Am J Hosp Palliat Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. González Infantino CA, González CD, Sánchez R, Presner N: Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding. Nutrition; 2013 Mar;29(3):497-501
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  • [Title] Hyperglycemia and hypoalbuminemia as prognostic mortality factors in patients with enteral feeding.
  • OBJECTIVE: To determine the association of in-hospital mortality in patients with enteral feeding to their glycemic status (normoglycemia, new hyperglycemia, or diabetes) and their levels of serum albumin.
  • At univariate analysis, in-hospital mortality was associated with age, known diabetes, newly diagnosed hyperglycemia, and albumin level.
  • Hypoalbuminemia (<2.55 g/dL) also was significantly associated with mortality (univariate odds ratio ≈2.7).
  • At multivariate analysis, in-hospital mortality was associated with age, newly diagnosed hyperglycemia, hypoalbuminemia (<2.55 g/dL), and known diabetes.
  • No interactions between hypoalbuminemia and known diabetes or newly diagnosed hyperglycemia were detected at multivariate analysis.
  • CONCLUSION: The results of this study showed that newly diagnosed hyperglycemia can be considered an independent prognostic factor of in-hospital mortality in patients with enteral feeding and that there is no interaction between newly diagnosed hyperglycemia and serum albumin levels.
  • [MeSH-major] Enteral Nutrition / mortality. Hospital Mortality. Hyperglycemia / mortality. Hypoalbuminemia / mortality

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23398919.001).
  • [ISSN] 1873-1244
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Verbeek L, Middeldorp JM, Hulzebos CV, Oepkes D, Walther FJ, Lopriore E: Hypoalbuminemia in donors with twin-twin transfusion syndrome. Fetal Diagn Ther; 2013;33(2):98-102
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in donors with twin-twin transfusion syndrome.
  • OBJECTIVE: To estimate the differences in albumin levels between donors and recipients with twin-twin transfusion syndrome (TTTS).
  • METHODS: We performed a matched case-control study including twin pairs with TTTS treated conservatively (conservative group) or with fetoscopic laser surgery (laser group) and analyzed the albumin levels at birth in donor and recipient twins.
  • Median albumin levels in donor twins in the conservative group were significantly lower than in recipient twins, 25.0 versus 33.0 g/l, respectively (p = 0.001).
  • In the laser group, albumin levels in donors and recipients were similar, 32.0 versus 32.0 g/l, respectively (p = 0.633).
  • Hypoalbuminemia (albumin level <20 g/l) occurred in 22% (4/18) of donor twins in the conservative group.
  • CONCLUSIONS: Hypoalbuminemia occurs frequently in donor twins with TTTS treated conservatively.
  • In TTTS treated with laser, donor twins have similar and normal albumin levels compared to recipients, confirming a successfully performed fetoscopic laser procedure.
  • [MeSH-major] Blood Donors. Fetofetal Transfusion / therapy. Hypoalbuminemia / blood. Iatrogenic Disease. Serum Albumin / analysis

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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 23208016.001).
  • [ISSN] 1421-9964
  • [Journal-full-title] Fetal diagnosis and therapy
  • [ISO-abbreviation] Fetal. Diagn. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / ALB protein, human; 0 / Serum Albumin
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14. Famakin B, Weiss P, Hertzberg V, McClellan W, Presley R, Krompf K, Karp H, Frankel MR: Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry. J Stroke Cerebrovasc Dis; 2010 Jan;19(1):17-22
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  • [Title] Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry.
  • Univariate analysis showed that mortality was associated with older age (P = .0008), stroke type (P = .0051), Glasgow Coma Scale score less than 9 (P < .0001), decreased serum albumin (P = .0001), elevated creatinine (P = .0067), and elevated blood glucose (P = .0063).
  • In the multivariate analysis, independent risk factors for mortality after acute stroke included older age (P = .004), stroke type (P = .0007), Glasgow Coma Scale score less than 9 (P < .0001), and decreased serum albumin (P = .0003).
  • CONCLUSION: In addition to previously recognized predictors of inhospital mortality, we found hypoalbuminemia to be an independent predictor of mortality in a biracial cohort of patients with acute stroke.
  • [MeSH-major] Hypoalbuminemia / mortality. Stroke / mortality

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  • (PMID = 20123222.001).
  • [ISSN] 1532-8511
  • [Journal-full-title] Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • [ISO-abbreviation] J Stroke Cerebrovasc Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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15. Guest S: Hypoalbuminemia in peritoneal dialysis patients. Adv Perit Dial; 2013;29:55-60
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  • [Title] Hypoalbuminemia in peritoneal dialysis patients.
  • Traditionally, serum albumin has been an indicator of nutrition status and has therefore been included in monthly blood testing in most centers.
  • The development of hypoalbuminemia in dialysis patients has been associated with increased mortality and often leads to interventions such as trials of nutritional supplements.
  • In PD, hypoalbuminemia combined with ongoing losses of protein into effluent raise particular concerns with clinicians.
  • Serum albumin may be affected by a variety of non-nutrition factors such as inflammation, volume status, and comorbidities.
  • Albumin synthesis in the liver exceeds, in most cases, albumin losses in urine or effluent.
  • Interpreting the medical implications of declining serum albumin in PD patients can therefore be a challenge.
  • The nutritional and non-nutritional factors affecting serum albumin are discussed, with specific emphasis on how membrane physiology contributes to dialysate protein losses.
  • A general clinical approach to the PD patient developing hypoalbuminemia is discussed.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / prevention & control. Peritoneal Dialysis / adverse effects

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  • (PMID = 24344493.001).
  • [ISSN] 1197-8554
  • [Journal-full-title] Advances in peritoneal dialysis. Conference on Peritoneal Dialysis
  • [ISO-abbreviation] Adv Perit Dial
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Membranes, Artificial
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16. Eljaiek R, Dubois MJ: Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients. Burns; 2013 Feb;39(1):113-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in burned patients.
  • OBJECTIVE: Hypoalbuminemia is a common finding in burned patients, but its association with increased morbidity and mortality has not been well established.
  • We assessed whether hypoalbuminemia in the first 24h of admission is associated with organ dysfunction in patients with severe burns.
  • A multiple linear regression analysis was conducted to assess hypoalbuminemia as an independent predictor of organ dysfunction.
  • Multiple linear regression analysis showed that hypoalbuminemia in the first 24h of admission was an independent predictor of organ dysfunction.
  • Serum albumin concentration ≤ 30 g/L was associated with a two-fold increase in organ dysfunction [SOFA scores at day 0 (p=0.005), day 1 (p=0.005) and first week mean values (p=0.004)], but not with mortality (p=0.061).
  • CONCLUSION: Hypoalbuminemia is associated with organ dysfunction in burned patients.
  • Unlike unmodifiable predictors such as age, burn surface and inhalation burn, correction of hypoalbuminemia might represent a goal for a future trial in burn patients.
  • [MeSH-major] Burns / complications. Hypoalbuminemia / etiology. Multiple Organ Failure / etiology

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  • [Copyright] Copyright © 2012 Elsevier Ltd and ISBI. All rights reserved.
  • (PMID = 22683139.001).
  • [ISSN] 1879-1409
  • [Journal-full-title] Burns : journal of the International Society for Burn Injuries
  • [ISO-abbreviation] Burns
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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17. Borda F, Borda A, Jiménez J, Zozaya JM, Prieto C, Gómez M, Urman J, Ibáñez B: [Predictive value of pre-treatment hypoalbuminemia in prognosis of resected colorectal cancer]. Gastroenterol Hepatol; 2014 May;37(5):289-95
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  • [Title] [Predictive value of pre-treatment hypoalbuminemia in prognosis of resected colorectal cancer].
  • [Transliterated title] Valor predictivo de la hipoalbuminemia pre-tratamiento sobre el pronóstico del cáncer colorrectal resecado.
  • Univariate and multivariate analyses of survival curves were performed in patients with and without pre-treatment hypoalbuminemia (<3.5g/dl), both in the overall group of patients and in the subgroup of those with pTNM stage ii tumors.
  • In addition, we compared the 5-year tumor-related mortality in patients with and without hypoalbuminemia.
  • In the overall multivariate analysis, survival curves were better in patients with normal albumin levels than in those with hypoalbuminemia (HR=2.82; CI 95%=[1.54-5.19]; P=.001).
  • This better prognostic value of normal albumin levels was also significant in pTNM stage ii tumors: (HR=3.76; CI 95%=[1.40-10.08]; P=.009).
  • The 5-year mortality index was lower in patients with normal albumin levels: overall series=18.8% vs 42.9% (OR=3.24; CI 95%=[1.48-7.12]; p=0.001); pTNM stage ii=13.3% vs 44.4% (OR=5.2; CI 95%=[1.36-20.34]; P=0.004).
  • CONCLUSIONS: Pre-treatment hypoalbuminemia (<3.5g/dl) was independently related to shorter survival after tumor resection, both in the overall series of patients and in pTNM stage ii CRC.
  • If these results are confirmed, hypoalbuminemia would be a simple and significant marker of poor prognosis, available at the initial diagnosis.

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  • [Copyright] Copyright © 2013 Elsevier España, S.L. and AEEH y AEG. All rights reserved.
  • (PMID = 24582765.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Keywords] NOTNLM ; Albumin / Albúmina / Colorectal cancer / Cáncer colorrectal / Supervivencia / Survival
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18. Chen Y, Ma WQ, Chen JM, Cai JT: Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia. World J Gastroenterol; 2010 Feb 14;16(6):782-4
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  • [Title] Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia.
  • A female patient with anemia and hypoalbuminemia was admitted to our hospital due to an over 20-year history of recurrent dizziness, fatigue and ankle edema.
  • [MeSH-major] Anemia / etiology. Hypoalbuminemia / etiology. Ileal Diseases / complications. Ileal Diseases / diagnosis. Ulcer / complications. Ulcer / diagnosis

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  • (PMID = 20135730.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology : WJG
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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  • [Chemical-registry-number] 0 / Albumins; E1UOL152H7 / Iron
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19. Nagai S, Saito Y, Endo Y, Saito T, Sugai K, Ishiyama A, Komaki H, Nakagawa E, Sasaki M, Ito K, Saito Y, Sukigara S, Ito M, Goto Y, Ito S, Matsuoka K: Hypoalbuminemia in early onset dentatorubral-pallidoluysian atrophy due to leakage of albumin in multiple organs. J Neurol; 2013 May;260(5):1263-71
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  • [Title] Hypoalbuminemia in early onset dentatorubral-pallidoluysian atrophy due to leakage of albumin in multiple organs.
  • We delineate a complication of hypoalbuminemia in dentatorubral-pallidoluysian atrophy (DRPLA), which we have found to be common in this disorder.
  • Eight DRPLA patients showed hypoalbuminemia <3.5 g/dl in the initial stages of the disease (age, 2-32 years), which correlated with the CAG repeat length in each patient.
  • Disease worsened in six patients, often triggered by febrile infections and accompanied by increased urinary protein excretion.
  • One patient showed increased fecal α1-antitripsin while another showed accumulation of radioactive albumin in the urinary and gastrointestinal tracts after intravenous infusion.
  • Immunohistochemistry revealed albumin-containing monocytes and astrocytes in the perivascular areas of the cerebral white matter.
  • Immunolabeling using antibodies against the expanded polyglutamine (polyQ) polypeptide was positive in cerebral cortical neurons, hepatocytes, renal collecting ducts, and glomerular podocytes, which act as filtration barrier against serum proteins.
  • Serum albumin appears to easily leak from blood vessels in certain visceral organs in DRPLA during later stages of the illness, particularly in the kidneys of patients with largely expanded CAG repeats.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / genetics. Myoclonic Epilepsies, Progressive. Serum Albumin / metabolism

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  • (PMID = 23263592.001).
  • [ISSN] 1432-1459
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Nerve Tissue Proteins; 0 / Peptides; 0 / Serum Albumin; 0 / atrophin-1; 26700-71-0 / polyglutamine
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20. Bozic MA, Howenstine MS, Maguiness KM, Molleston JP: Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis. Nutr Clin Pract; 2010 Jun;25(3):304-7
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  • [Title] Hypoalbuminemia in a cystic fibrosis patient with severe erosive esophagitis.
  • An 8-year-old patient with cystic fibrosis presented with hypoalbuminemia as the main symptom of severe erosive esophagitis.
  • Extensive evaluation failed to reveal a nutrition, pancreatic, intestinal, or renal explanation of his hypoalbuminemia.
  • Identification and treatment of the esophagitis led to resolution of the hypoalbuminemia.
  • [MeSH-major] Cystic Fibrosis / complications. Esophagitis, Peptic / complications. Gastroesophageal Reflux / complications. Hypoalbuminemia / etiology


21. Kim Y, Molnar MZ, Rattanasompattikul M, Hatamizadeh P, Benner D, Kopple JD, Kovesdy CP, Kalantar-Zadeh K: Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis. Int Urol Nephrol; 2013 Feb;45(1):215-27
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  • [Title] Relative contributions of inflammation and inadequate protein intake to hypoalbuminemia in patients on maintenance hemodialysis.
  • PURPOSE: Serum albumin is one of the strongest mortality predictors in maintenance hemodialysis (MHD) patients.
  • Yet, the degree to which serum albumin represents dietary protein intake or an inflammatory state, among others, is not clear.
  • We hypothesize that these inadequate protein intake and inflammation contribute somewhat equally to hypoalbuminemia.
  • METHODS: In a cross-sectional analysis, we examined correlates of low serum albumin, <3.8 g/dL, in 812 MHD patients in whom interleukin-6 (IL-6) and normalized protein nitrogen appearance (nPNA), also known as normalized protein catabolic rate (nPCR), were also measured.
  • Logistic regression estimated odds ratios were employed, and spline models were plotted to examine the likelihood of relatively low serum albumin <3.8 g/dL.
  • The baseline serum albumin, averaged over a 3-month period (mean ± SD), was 3.88 ± 0.38 g/mL.
  • The unadjusted correlation coefficients of l IL-6 and nPNA with serum albumin were -0.36 and +0.20, respectively (p < 0.001 for each comparison).
  • The likelihood for an albumin <3.8 gr/dL increased linearly with decreasing nPNA and rising serum IL-6.
  • This trend was steeper with increasing serum IL-6 up to a concentration of 30 ng/mL.
  • CONCLUSIONS: Both low protein intakes and a high state of inflammation are associated with low serum albumin in MHD patients.
  • [MeSH-major] Dietary Proteins / metabolism. Hypoalbuminemia / etiology. Inflammation / complications. Protein Deficiency / complications. Renal Dialysis
  • [MeSH-minor] Adult. Aged. C-Reactive Protein / metabolism. Creatinine / blood. Cross-Sectional Studies. Female. Humans. Interleukin-6 / blood. Logistic Models. Male. Middle Aged. Odds Ratio. Renal Insufficiency, Chronic / blood. Renal Insufficiency, Chronic / therapy. Serum Albumin / metabolism

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  • (PMID = 22528583.001).
  • [ISSN] 1573-2584
  • [Journal-full-title] International urology and nephrology
  • [ISO-abbreviation] Int Urol Nephrol
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK61162; United States / NCRR NIH HHS / RR / M01-RR00425; United States / NCATS NIH HHS / TR / UL1 TR000124
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dietary Proteins; 0 / Interleukin-6; 0 / Serum Albumin; 9007-41-4 / C-Reactive Protein; AYI8EX34EU / Creatinine
  • [Other-IDs] NLM/ NIHMS659199; NLM/ PMC4336193
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22. Crumley AB, Stuart RC, McKernan M, McMillan DC: Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer? World J Surg; 2010 Oct;34(10):2393-8
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  • [Title] Is hypoalbuminemia an independent prognostic factor in patients with gastric cancer?
  • BACKGROUND: Studies have indicated that hypoalbuminemia is associated with decreased survival of patients with gastric cancer.
  • However, the prognostic value of albumin may be secondary to an ongoing systemic inflammatory response.
  • The aim of the study was to assess the relation between hypoalbuminemia, the systemic inflammatory response, and survival in patients with gastric cancer.
  • METHODS: Patients diagnosed with gastric carcinoma attending the upper gastrointestinal surgical unit in the Royal Infirmary, Glasgow between April 1997 and December 2005 and who had a pretreatment measurement of albumin and C-reactive protein (CRP) were studied.
  • RESULTS: Most of the patients had stage III/IV disease and received palliative treatment.
  • On univariate analysis, stage (p < 0.001), treatment (p < 0.001), albumin level (p < 0.001), and CRP level (p < 0.001) were significant predictors of survival.
  • On multivariate analysis, stage (p < 0.001), treatment (p < 0.001), and CRP level (p < 0.001) remained significant predictors of survival.
  • Albumin was no longer an independent predictor of survival.
  • CONCLUSIONS: Low albumin concentrations are associated with poorer survival in patients with gastric cancer.
  • However, the strength of this relation with survival is dependent on the presence of a systemic inflammatory response, as evidenced by an elevated CRP level.
  • Therefore, it appears that the relation between hypoalbuminemia and poor survival is secondary to that of the systemic inflammatory response.
  • [MeSH-major] Hypoalbuminemia / mortality. Stomach Neoplasms / blood. Stomach Neoplasms / mortality. Systemic Inflammatory Response Syndrome / mortality

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  • [CommentIn] World J Surg. 2010 Oct;34(10):2399-400 [20602100.001]
  • (PMID = 20602101.001).
  • [ISSN] 1432-2323
  • [Journal-full-title] World journal of surgery
  • [ISO-abbreviation] World J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 9007-41-4 / C-Reactive Protein
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23. Komrokji RS, Corrales-Yepez M, Kharfan-Dabaja MA, Al Ali NH, Padron E, Rollison DE, Pinilla-Ibarz J, Zhang L, Epling-Burnette PK, Lancet JE, List AF: Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes. Am J Hematol; 2012 Nov;87(11):1006-9
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  • [Title] Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes.
  • We hypothesized that hypoalbuminemia is an independent prognostic factor in patients with myelodysplastic syndromes (MDS).
  • We analyzed records of 767 patients treated at Moffitt Cancer Center between January 2001 and December 2009 to evaluate the relationship between serum albumin (SA) at the time of presentation and overall survival (OS).
  • Patients (median age of 69 years) were stratified into three groups based on SA concentration (≤3.5, 3.6-4.0, and >4.0 g/dL).
  • Two-thirds of the patients had low or intermediate-1 International Prognostic Scoring System (IPSS)-based risk for MDS.
  • Median OS by SA concentration of ≤3.5, 3.6-4.0, and >4.0 g/dL was 11, 23, and 34 months, respectively (P < 0.005), whereas rate of acute myeloid leukemia progression was highest in patients with low SA (≤3.5 g/dL).
  • The SA level offered prognostic discrimination for outcomes within the lower and higher IPSS risk groups, as well as with the MD Anderson risk model.
  • In multivariable analysis, SA was a significant independent co-variate for OS after adjustment for IPSS, age, serum ferritin, and transfusion dependence (hazard ratio = 0.8; 95% CI 0.6-0.9; P = 0.004).
  • Our findings indicate that hypoalbuminemia is an independent prognostic biomarker that may serve as a surrogate representative of disease biology or comorbidities in patients with MDS.
  • [MeSH-major] Hypoalbuminemia / mortality. Myelodysplastic Syndromes / mortality. Serum Albumin / analysis


24. Vahedi A, Lotfinia I, Sad RB, Halimi M, Baybordi H: Relationship between admission hypoalbuminemia and inhospital mortality in acute stroke. Pak J Biol Sci; 2011 Jan 15;14(2):118-22
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  • [Title] Relationship between admission hypoalbuminemia and inhospital mortality in acute stroke.
  • This study aims at assessing the relation between hypoalbuminemia and inhospital mortality in patients with acute stroke.
  • Admission hypoalbuminemia (serum albumin < 3.5 mg dL(-) as well as other prognostic factors were determined and compared between the two groups.
  • 43% of the patients were Hypoalbuminemia.
  • Frequency of patients with admission hypoalbuminemia and is chemic heart disease was significantly higher in the nonsurvivors (75.8-32.5%, p = 0.001; 34.5 vs. 16.9%, p = 0.047, respectively).
  • In conclusion, hypoalbuminemia is an independent predictor of inhospital mortality in patients with acute stroke.
  • [MeSH-major] Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Serum Albumin / metabolism. Stroke / complications. Stroke / mortality

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  • (PMID = 21916262.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 0 / Serum Albumin
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25. Bonilla-Palomas JL, Gámez-López AL, Moreno-Conde M, López-Ibáñez MC, Anguita-Sánchez M, Gallego de la Sacristana A, García-Catalán F, Villar-Ráez A: Hypoalbuminemia in acute heart failure patients: causes and its impact on hospital and long-term mortality. J Card Fail; 2014 May;20(5):350-8
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  • [Title] Hypoalbuminemia in acute heart failure patients: causes and its impact on hospital and long-term mortality.
  • BACKGROUND: The causes of hypoalbuminemia in patients with acute heart failure (HF) remain poorly defined, and the association between hypoalbuminemia and hospital and long-term mortality has been only partially evaluated.
  • This study sought to analyze the causes of hypoalbuminemia in acute HF patients and determine its impact on hospital and long-term mortality.
  • The patients were divided into 2 groups according to the presence or absence of hypoalbuminemia (albumin ≤3.4 g/dL), and the independent association of each variable with hypoalbuminemia and hospital mortality was assessed with the use of multiple logistic regression.
  • The association between hypoalbuminemia and long-term mortality was assessed with the use of Cox multivariate analysis.
  • In total, 108 patients (29.8%) were classified as having hypoalbuminemia.
  • Older age, higher C-reactive protein levels, and lower levels of total protein, prealbumin, transferrin, and lymphocytes were independently associated with hypoalbuminemia.
  • Hospital mortality was 8% and was independently associated with hypoalbuminemia.
  • Hypoalbuminemia was an independent predictor of mortality.
  • CONCLUSIONS: Hypoalbuminemia in acute HF patients was associated with higher hospital mortality and served as an independent predictor of long-term mortality.
  • Malnutrition and inflammation were factors causing hypoalbuminemia in this clinical setting.

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  • [Copyright] Copyright © 2014 Elsevier Inc. All rights reserved.
  • (PMID = 24486927.001).
  • [ISSN] 1532-8414
  • [Journal-full-title] Journal of cardiac failure
  • [ISO-abbreviation] J. Card. Fail.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Inflammation / congestion / malnutrition
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26. Nisar PJ, Appau KA, Remzi FH, Kiran RP: Preoperative hypoalbuminemia is associated with adverse outcomes after ileoanal pouch surgery. Inflamm Bowel Dis; 2012 Jun;18(6):1034-41
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  • [Title] Preoperative hypoalbuminemia is associated with adverse outcomes after ileoanal pouch surgery.
  • BACKGROUND: This study examines the association between preoperative albumin and ileoanal pouch (IPAA) outcomes and the utility of serum albumin in the decision to perform a staged IPAA with an initial subtotal colectomy.
  • METHODS: From 2001-2009, patients were identified from an institutional pouch database and albumin values were extracted from the clinic data repository.
  • Hypoalbuminemic (albumin <3.5 g/dL) patients were compared with patients with normal albumin.
  • Pre-IPAA hypoalbuminemia was associated with pouch failure (P = 0.004).
  • Pre-IPAA hypoalbuminemia was an independent predictor of anastomotic leak (P = 0.017).
  • Pre-IPAA hypoalbuminemia was an independent predictor of prolonged length of stay (LOS) (P < 0.001).
  • CONCLUSIONS: Preoperative serum albumin is an easily available, inexpensive marker in risk stratifying patients undergoing ileoanal pouch surgery.
  • Serum albumin may provide an objective indicator in supporting the decision to undertake a subtotal colectomy as a first step rather than total proctocolectomy with immediate pouch creation.
  • [MeSH-major] Anastomotic Leak / etiology. Colitis / surgery. Colonic Pouches / adverse effects. Hypoalbuminemia / etiology. Postoperative Complications. Proctocolectomy, Restorative
  • [MeSH-minor] Adult. Anastomosis, Surgical. Colectomy. Female. Follow-Up Studies. Humans. Length of Stay. Male. Preoperative Care. Prognosis. Prospective Studies. Quality of Life. Serum Albumin / analysis

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  • [Copyright] Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.
  • (PMID = 22605611.001).
  • [ISSN] 1536-4844
  • [Journal-full-title] Inflammatory bowel diseases
  • [ISO-abbreviation] Inflamm. Bowel Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
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27. Sasatomi Y, Ito K, Abe Y, Miyake K, Ogahara S, Nakashima H, Saito T: Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. Ren Fail; 2012;34(2):189-93
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  • [Title] Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis.
  • BACKGROUND: Anemia in patients with early diabetes mellitus nephrosclerosis (DMN) is more severe than in patients with kidney disease of other origins, and the mechanism for this remains unclear.
  • We then divided the clusters with regard to renal prognosis and survival and carried out simple and multifactorial analysis of clinical data, including the body mass index, age, systolic blood pressure (BP), diastolic BP, duration after the diagnosis of diabetes mellitus, serum albumin levels, blood urea nitrogen (BUN) concentrations, serum creatinine concentrations, the estimated glomerular filtration rate (eGFR) validated in the Japanese population, iron levels, total cholesterol levels, triglyceride levels, fasting blood sugar levels, HbA1c levels, urinary protein secretion, and pathohistological parameters.
  • RESULTS: The factors that were significantly associated with the cluster group that showed severe anemia were sex (p = 0.0162), hypoalbuminemia (p < 0.0001), high BUN concentrations (p = 0.0020), low eGFR (p = 0.0104), and Kimmelstiel-Wilson nodules (p = 0.0022).
  • In addition, hypoalbuminemia (p = 0.0277), high BUN concentrations (p = 0.0338), and a low eGFR (p = 0.0417) were significantly associated with this group in a multifactorial analysis.
  • CONCLUSION: Our data strongly suggest that hypoalbuminemia is associated with severe anemia in DMN patients.
  • [MeSH-major] Anemia / etiology. Diabetic Nephropathies / complications. Hypoalbuminemia / etiology. Nephrosclerosis / complications


28. Frisbie JH: Anemia and hypoalbuminemia of chronic spinal cord injury: prevalence and prognostic significance. Spinal Cord; 2010 Jul;48(7):566-9
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  • [Title] Anemia and hypoalbuminemia of chronic spinal cord injury: prevalence and prognostic significance.
  • OBJECTIVE: The objective of the study was to survey a chronic spinal cord injury (SCI) population for the prevalence and prognostic significance of anemia (AN) and hypoalbuminemia (HA).
  • The number of follow-up years with AN (hematocrit <40%) or severe anemia (SAN) (hematocrit <30%) or HA (serum albumin <3 g%) was recorded for all subjects, divided between survivor and deceased subjects.
  • The level and grade of paralysis were similar in these groups.
  • The fractions of survey years that were positive for SAN and/or HA among causes of death were sepsis, 42%; cancer, 33%; pulmonary failure 30%; cardiovascular disease, 25%; and undetermined causes, 9%.
  • [MeSH-major] Anemia / diagnosis. Anemia / epidemiology. Hypoalbuminemia / diagnosis. Hypoalbuminemia / epidemiology. Spinal Cord Injuries / diagnosis. Spinal Cord Injuries / epidemiology
  • [MeSH-minor] Adult. Age Factors. Chronic Disease. Cohort Studies. Female. Humans. Male. Middle Aged. Statistics as Topic

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  • (PMID = 19949419.001).
  • [ISSN] 1476-5624
  • [Journal-full-title] Spinal cord
  • [ISO-abbreviation] Spinal Cord
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
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29. Al Helal B, Su WS, Churchill DN, Gangji AS: Relative hypoparathyroidism and hypoalbuminemia are associated with hip fracture in hemodialysis patients. Clin Nephrol; 2010 Feb;73(2):88-93
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  • [Title] Relative hypoparathyroidism and hypoalbuminemia are associated with hip fracture in hemodialysis patients.
  • AIMS: Patients with end-stage renal disease treated by hemodialysis are at an increased risk of hip fracture.
  • RESULTS: Variables associated with hip fracture were a reduction in serum parathyroid hormone by 100 pg/ml (OR = 1.65, 95% CI 1.10, 2.46) and a decrease in serum albumin by 1 g/l (OR = 1.18, 95% CI 1.00, 1.39).
  • Median survival time in patients with hip fracture and a serum PTH value < 100 pg/ml was 17 days (95% CI 0, 37 days) as compared with 280 days (95% CI 103, 471 days) for those with a PTH value > 100 pg/ml (p < 0.02).
  • CONCLUSIONS: Relative hypoparathyroidism and hypoalbuminemia are associated with an increased risk of hip fracture in hemodialysis patients.
  • [MeSH-major] Hip Fractures / etiology. Hypoalbuminemia / complications. Hypoparathyroidism / complications. Kidney Failure, Chronic / therapy. Renal Dialysis / adverse effects


30. Lee CS, Min IS, Hwang JH, Kwon KS, Lee HB: Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus. BMC Infect Dis; 2010;10:216
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  • [Title] Clinical significance of hypoalbuminemia in outcome of patients with scrub typhus.
  • BACKGROUND: This study was designed to investigate the clinical significance of hypoalbuminemia as a marker of severity and mortality in patients with Scrub typhus.
  • METHODS: The patients with scrub typhus were divided into two groups based on the serum albumin levels; Group I (serum albumin <3.0 g/dL) and Group II (serum albumin >or=3.0 g/dL).
  • The outcome of patients with hypoalbuminemia was compared with that of normoalbuminemia.
  • CONCLUSIONS: This study showed hypoalbuminemia in scrub typhus was closely related to the frequency of various complication, longer hospital stay, consequently the higher medical cost, necessitating more efficient management of patients, including medical resources.
  • [MeSH-major] Hypoalbuminemia. Scrub Typhus / complications. Scrub Typhus / diagnosis

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  • (PMID = 20646323.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2919547
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31. Mizuno T, Mizokami F, Fukami K, Ito K, Shibasaki M, Nagamatsu T, Furuta K: The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia. Clin Interv Aging; 2013;8:1323-8
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  • [Title] The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia.
  • BACKGROUND: Vancomycin (VCM) treatment outcomes depend on the characteristics of the patient, and it is well known that hypoalbuminemia is a risk factor for poor treatment outcomes, as reported in a previous study.
  • However, the reason that severe hypoalbuminemia has an influence on the treatment outcome of VCM remains unknown.
  • OBJECTIVE: To elucidate the association between severe hypoalbuminemia and VCM treatment outcomes, we examined pharmacokinetic/pharmacodynamic (PK/PD) parameters in elderly patients with severe hypoalbuminemia.
  • The 94 patients were divided into severe hypoalbuminemia and non-severe hypoalbuminemia groups.
  • RESULTS: The half-life of VCM in the severe hypoalbuminemia group was significantly longer than in the non-severe hypoalbuminemia group (33.2 + 5.4 vs 24.9 + 1.6; P = 0.049).
  • Area under the concentration curve (AUC)/minimum inhibitory concentration (MIC) values of 250-450 and >450 μg × h/mL were significantly associated with 28-day mortality in the severe hypoalbuminemia group (P < 0.001), whereas AUC/MIC values of <250 μg × h/mL were not associated.
  • We also detected a significant difference in the increased percentage of nephrotoxicity in the severe hypoalbuminemia group (6 of 23 patients [26%]) compared with the non-severe hypoalbuminemia group (6 of 71 patients [8%]; P < 0.001).
  • CONCLUSION: These findings indicate that severe hypoalbuminemia influences the half-life of VCM and treatment outcomes in elderly patients (≥75 years of age).
  • [MeSH-major] Anti-Bacterial Agents / therapeutic use. Cross Infection / drug therapy. Hypoalbuminemia / complications. Methicillin-Resistant Staphylococcus aureus / drug effects. Pneumonia, Bacterial / drug therapy. Vancomycin / therapeutic use

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  • (PMID = 24109180.001).
  • [ISSN] 1178-1998
  • [Journal-full-title] Clinical interventions in aging
  • [ISO-abbreviation] Clin Interv Aging
  • [Language] eng
  • [Publication-type] Journal Article; Observational Study
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 6Q205EH1VU / Vancomycin
  • [Other-IDs] NLM/ PMC3793010
  • [Keywords] NOTNLM ; elderly patients / methicillin-resistant Staphylococcus aureus / pharmacodynamics / pharmacokinetics / severe hypoalbuminemia / vancomycin
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32. Snyder CW, Biggio JR, Bartle DT, Georgeson KE, Muensterer OJ: Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis. Pediatr Surg Int; 2011 Nov;27(11):1155-8
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  • [Title] Early severe hypoalbuminemia is an independent risk factor for intestinal failure in gastroschisis.
  • OBJECTIVE: This study attempted to evaluate the association of early hypoalbuminemia with the risk of intestinal failure in gastroschisis patients.
  • PATIENTS AND METHODS: Neonates with gastroschisis treated at a tertiary children's hospital over a 10-year period were initially categorized into groups based on the lowest serum albumin measurement during the first 7 days of life.
  • Based on preliminary analysis, patients with serum albumin <1.5 g/dL were considered to have early severe hypoalbuminemia.
  • RESULTS: One hundred and thirty-five gastroschisis patients were included, of whom 21% had early severe hypoalbuminemia.
  • Patients with early severe hypoalbuminemia had a significantly higher risk of intestinal failure compared to those with higher albumin levels (26 vs. 8%, p = 0.015).
  • On multivariable logistic regression modeling, early severe hypoalbuminemia was strongly associated with intestinal failure (OR 6.4, 95% CI 1.8-23.3, p = 0.005).
  • CONCLUSIONS: Early severe hypoalbuminemia appears to be an independent risk factor for long-term intestinal compromise rather than merely an indicator of overall illness.
  • Further interventional studies are needed to determine whether clinical protocols utilizing judicious fluid administration, exogenous albumin, and early enteral feeding can improve clinical outcomes in gastroschisis.
  • [MeSH-major] Edema / complications. Gastroschisis / complications. Hypoalbuminemia / etiology. Ileus / complications


33. Bleske BE, Clark MM, Wu AH, Dorsch MP: The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia. J Cardiovasc Pharmacol Ther; 2013 Jul;18(4):334-7
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  • [Title] The effect of continuous infusion loop diuretics in patients with acute decompensated heart failure with hypoalbuminemia.
  • PURPOSE: Hypoalbuminemia is believed to decrease diuretic effectiveness and contribute to diuretic resistance that is observed in patients with nephrotic syndrome.
  • Hypoalbuminemia is also seen in patients with acute decompensated heart failure (ADHF).
  • However, the role of hypoalbuminemia on the effectiveness of continuous infusion diuretics in patients with ADHF is not known.
  • METHODS: To evaluate hypoalbuminemia (albumin ≤ 3 g/dL) and diuretic effectiveness, we performed a retrospective study in 162 patients admitted to a tertiary care center for treatment of ADHF over a 3-year period.
  • RESULTS: A total of 33 patients were determined to have hypoalbuminemia.
  • Average net urine output over a 2-day study period was similar between patients with and without hypoalbuminemia (-1462 ± 1734 vs -1233 ± 1560 mL, P = .46, respectively).
  • In addition, diuretic doses (furosemide equivalent/24 hours) were similar between the 2 groups (788 ± 671 vs 778 ± 713 mg, P = .91, respectively) as was baseline serum creatinine (1.6 ± 0.6 vs 1.6 ± 0.6 mg/dL, P = .5, respectively).
  • CONCLUSION: Overall, hypoalbuminemia did not decrease the diuretic effectiveness when measured by the net urine output in patients receiving continuous infusion diuretics for the treatment of ADHF.
  • [MeSH-major] Heart Failure / drug therapy. Hypoalbuminemia / drug therapy. Sodium Potassium Chloride Symporter Inhibitors / therapeutic use
  • [MeSH-minor] Acute Disease. Adult. Aged. Blood Pressure. Blood Urea Nitrogen. Bumetanide / therapeutic use. Creatinine / blood. Diuretics / therapeutic use. Female. Humans. Infusions, Intravenous / methods. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 23424098.001).
  • [ISSN] 1940-4034
  • [Journal-full-title] Journal of cardiovascular pharmacology and therapeutics
  • [ISO-abbreviation] J. Cardiovasc. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diuretics; 0 / Sodium Potassium Chloride Symporter Inhibitors; 0Y2S3XUQ5H / Bumetanide; AYI8EX34EU / Creatinine
  • [Keywords] NOTNLM ; continuous infusion / diuretics / heart failure / hypoalbuminemia
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34. Porrett PM, Baranov E, ter Horst M: Serum hypoalbuminemia predicts late mortality on the liver transplant waiting list. Transplantation; 2015 Jan;99(1):158-63
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  • [Title] Serum hypoalbuminemia predicts late mortality on the liver transplant waiting list.
  • Although estimation of 90-day mortality by Model for End-Stage Liver Disease (MELD) score has improved wait list survival, it is unclear how contemporary wait list mortality can best be diminished given the preponderance of listed patients with low MELD scores and long wait times.
  • Hypoalbuminemia at listing was a significant predictor of late mortality in all patients in both univariate and multivariate analyses, and it was most discriminatory among patients with MELD scores of 20 or less.
  • CONCLUSION: Our data suggest that hypoalbuminemia at listing reveals a vulnerable population of low MELD patients who are underserved by their MELD score over time.
  • Targeting these at-risk patients with grafts from living or extended criteria donors may thus significantly diminish overall list mortality, and future initiatives to decrease overall wait list mortality must focus on improved risk stratification for low MELD patients.
  • [MeSH-major] Hypoalbuminemia / blood. Hypoalbuminemia / mortality. Liver Diseases / blood. Liver Diseases / mortality. Liver Transplantation. Serum Albumin / analysis. Waiting Lists / mortality

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  • (PMID = 25050469.001).
  • [ISSN] 1534-6080
  • [Journal-full-title] Transplantation
  • [ISO-abbreviation] Transplantation
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ALB protein, human; 0 / Biological Markers; 0 / Serum Albumin
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35. Lakshmi C, Srinivas CR, Paul S, Chitra TV, Kanchanamalai K, Somasundaram LS: Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin. Indian J Dermatol; 2010 Apr-Jun;55(2):181-4
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  • [Title] Recurrent impetigo herpetiformis with diabetes and hypoalbuminemia successfully treated with cyclosporine, albumin, insulin and metformin.
  • We report the case of a patient with recurrent impetigo herpetiformis associated with diabetes mellitus, hypoalbuminemia, and hypocalcaemia; who was refractory to corticosteroids.

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  • [Cites] Arch Dermatol. 2002 Jan;138(1):128-9 [11790187.001]
  • [Cites] Clin Transplant. 2007 May-Jun;21(3):301-4 [17488376.001]
  • [Cites] Eur J Obstet Gynecol Reprod Biol. 2002 Mar 10;101(2):201-3 [11858900.001]
  • (PMID = 20606891.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2887526
  • [Keywords] NOTNLM ; Impetigo herpetiformis / cyclosporine / diabetes and hypoalbuminemia
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36. de la Cruz KI, Bakaeen FG, Wang XL, Huh J, LeMaire SA, Coselli JS, Chu D: Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis. Ann Thorac Surg; 2011 Mar;91(3):671-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypoalbuminemia and long-term survival after coronary artery bypass: a propensity score analysis.
  • BACKGROUND: Hypoalbuminemia is associated with increased morbidity in surgical patients.
  • The impact of low albumin level on survival in cardiac surgical patients is unknown.
  • We hypothesized that a low preoperative albumin level negatively affects long-term survival after coronary artery bypass graft (CABG) surgery.
  • Propensity score analysis of 18 preoperative and intraoperative variables balanced potential confounding factors between the two groups of patients, so that the final study cohort consisted of 588 patients: 294 with a preoperative albumin level less than 3.5 g/dL (ie, hypoalbuminemia) and 294 patients with a preoperative albumin level of 3.5 g/dL or greater.
  • However, patients with hypoalbuminemia had a significantly worse 8-year survival rate (65% ± 7% versus 86% ± 3%; hazard ratio 2.2; 95% confidence interval: 1.4 to 3.6; p = 0.001) than patients without hypoalbuminemia.
  • CONCLUSIONS: Although preoperative hypoalbuminemia did not predict increased early postoperative mortality or morbidity in CABG patients, it did independently predict poor long-term survival after CABG.
  • Identifying the mechanism that underlies this relationship is essential in improving overall survival among patients with low serum albumin levels who are undergoing surgical myocardial revascularization.
  • [MeSH-major] Coronary Artery Bypass. Hypoalbuminemia / epidemiology. Serum Albumin / metabolism

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  • [Copyright] Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
  • [CommentIn] Ann Thorac Surg. 2011 Dec;92(6):2305; author reply 2305-6 [22115261.001]
  • [CommentIn] Ann Thorac Surg. 2011 Mar;91(3):676 [21352978.001]
  • (PMID = 21352977.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Serum Albumin
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37. Okamura K, Nagata N, Wakamatsu K, Yonemoto K, Ikegame S, Kajiki A, Takayama K, Nakanishi Y: Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis. Intern Med; 2013;52(4):439-44
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  • [Title] Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis.
  • The serum albumin concentrations and peripheral blood lymphocyte counts were measured on admission, and the primary outcome of interest was in-hospital death.
  • The multivariate analysis revealed that the serum albumin concentrations (OR: 0.21, 95% CI: 0.10-0.41; p<0.0001) and peripheral blood total lymphocyte counts (Category 2 [627.2-1,106.7/mm(3)] vs. 1 [<627.2/mm(3)].
  • The serum albumin concentrations and peripheral blood total lymphocyte counts were also found to be associated with in-hospital deaths directly caused by TB.
  • CONCLUSION: Hypoalbuminemia and lymphocytopenia on admission are predictive risk factors for in-hospital mortality in TB patients.
  • [MeSH-major] Hospital Mortality. Hypoalbuminemia / complications. Hypoalbuminemia / mortality. Lymphopenia / complications. Lymphopenia / mortality. Tuberculosis / complications. Tuberculosis / mortality

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  • (PMID = 23411698.001).
  • [ISSN] 1349-7235
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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38. Laodim P, Intapan PM, Sawanyawisuth K, Prasongdee TK, Laummaunwai P, Maleewong W: Hypoalbuminemia as a predictor of diarrhea caused by blastocystis hominis. Southeast Asian J Trop Med Public Health; 2013 May;44(3):374-8
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  • [Title] Hypoalbuminemia as a predictor of diarrhea caused by blastocystis hominis.
  • We studied patients with positive stool samples for B. hominis by formalin ethyl acetate concentration technique at Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand between 2003 and 2010.
  • Only serum albumin level was significantly associated with diarrhea cases in this study with an adjusted OR of 0.162 and a 95% CI of 0.027- 0.957.
  • Hypoalbuminemia is associated with diarrhea associated with blastocystosis.
  • [MeSH-major] Blastocystis Infections / blood. Blastocystis Infections / epidemiology. Diarrhea / blood. Diarrhea / epidemiology. Hypoalbuminemia / epidemiology

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  • (PMID = 24050068.001).
  • [ISSN] 0125-1562
  • [Journal-full-title] The Southeast Asian journal of tropical medicine and public health
  • [ISO-abbreviation] Southeast Asian J. Trop. Med. Public Health
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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39. Critselis E, Panagiotakos DB, Machairas A, Zampelas A, Critselis AN, Polychronopoulos E: Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support. Int J Food Sci Nutr; 2012 Mar;63(2):208-15
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  • [Title] Risk and predictive factors of hypoalbuminemia in cancer patients following extensive abdominal surgery despite total parenteral nutritional support.
  • Postoperative hypoalbuminemia is associated with adverse outcomes, particularly in cancer patients.
  • The risk and predictors of hypoalbuminemia in cancer patients following extensive abdominal surgery (EAS), despite total parenteral nutrition (TPN) support, were evaluated.
  • EAS patients received daily TPN, including 200 mL of 5% human albumin solution.
  • Serum albumin (SA) levels and hypoalbuminemia (SA < 3.5 g/dL) were assessed daily.
  • EAS patients had an elevated risk of hypoalbuminemia during the first postoperative week [relative risk (RR): 3.12; 95% confidence interval (95% CI): 1.64-5.91].
  • Postoperative hypoalbuminemia was associated with surgery duration (RR: 1.76; 95% CI: 1.32-2.36), preoperative SA (RR: 0.24; 95% CI: 0.11-0.55), blood (RR: 1.46; 95% CI: 1.04-2.04) and Ringer's lactated solution (RR: 1.52; 95% CI: 1.12-2.07) volumes transfused intra-operatively.
  • Therefore, despite TPN, cancer patients who underwent EAS had an elevated risk of postoperative hypoalbuminemia.
  • [MeSH-major] Abdomen / surgery. Gastrointestinal Neoplasms / surgery. Hypoalbuminemia / etiology. Parenteral Nutrition, Total. Postoperative Complications. Serum Albumin / metabolism. Urogenital Neoplasms / surgery

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  • (PMID = 21939411.001).
  • [ISSN] 1465-3478
  • [Journal-full-title] International journal of food sciences and nutrition
  • [ISO-abbreviation] Int J Food Sci Nutr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Serum Albumin
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40. Lee EH, Chin JH, Choi DK, Hwang BY, Choo SJ, Song JG, Kim TY, Choi IC: Postoperative hypoalbuminemia is associated with outcome in patients undergoing off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth; 2011 Jun;25(3):462-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postoperative hypoalbuminemia is associated with outcome in patients undergoing off-pump coronary artery bypass graft surgery.
  • OBJECTIVE: The authors aimed to investigate whether immediate postoperative hypoalbuminemia could be associated with outcomes after off-pump coronary artery bypass graft (OPCAB) surgery.
  • MEASUREMENTS AND MAIN RESULTS: To evaluate the clinical relevance of immediate postoperative hypoalbuminemia, the lowest serum albumin level measured over the first 12 hours postoperatively was recorded.
  • The impact of immediate postoperative hypoalbuminemia on OPCAB outcome was investigated using multivariate analysis.
  • The cutoff value for immediate postoperative albumin concentration for predicting 30-day adverse events was 2.3 g/dL.
  • Immediate postoperative hypoalbuminemia (<2.3 g/dL) was associated independently with postoperative respiratory failure (odds ratio [OR] = 8.85, p = 0.04), wound infection (OR = 4.44, p = 0.04), the need for an intra-aortic balloon pump after the operation (OR = 13.7, p = 0.02), renal failure (OR = 7.98, p = 0.01), reoperation for bleeding (OR = 4.33, p = 0.05), and the need for inotropes in the intensive care unit (OR = 1.79, p = 0.02).
  • CONCLUSIONS: Immediate postoperative hypoalbuminemia was associated with poorer outcomes in OPCAB patients.
  • Monitoring of albumin levels after OPCAB could identify patients at risk for short-term adverse events.
  • [MeSH-major] Coronary Artery Bypass, Off-Pump / adverse effects. Hypoalbuminemia / etiology. Hypoalbuminemia / mortality. Postoperative Complications / etiology. Postoperative Complications / mortality

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21093290.001).
  • [ISSN] 1532-8422
  • [Journal-full-title] Journal of cardiothoracic and vascular anesthesia
  • [ISO-abbreviation] J. Cardiothorac. Vasc. Anesth.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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41. Cheng HC, Chang WL, Chen WY, Tsai YC, Yeh YC, Sheu BS: Intravenous albumin shortens the duration of hospitalization for patients with hypoalbuminemia and bleeding peptic ulcers: a pilot study. Dig Dis Sci; 2013 Nov;58(11):3232-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intravenous albumin shortens the duration of hospitalization for patients with hypoalbuminemia and bleeding peptic ulcers: a pilot study.
  • BACKGROUND: Patients with hypoalbuminemia have an increased risk of ulcer rebleeding and longer length of hospitalization.
  • AIMS: This study aimed to test whether intravenous albumin can decrease the incidence of rebleeding or shorten the duration of hospitalization in patients with bleeding peptic ulcers and hypoalbuminemia.
  • The enrolled patients were divided into a normal albumin group (serum albumin ≥ 3 g/dL, n = 39) or an intervention group (<3 g/dL, n = 23) to receive a 3-day course of omeprazole infusion and 25-day oral esomeprazole.
  • Patients (n = 29) with bleeding ulcers and hypoalbuminemia who received the same dose of intravenous and oral omeprazole but did not receive albumin therapy were enrolled from a previous study as the control group.
  • In the intervention group, patients received albumin infusion (10 g q8h) for 1 day (serum albumin levels 2.5-2.9 g/dL) and 2 days (<2.5 g/dL), respectively.
  • The risk of rebleeding developed after discharge were similar (normal albumin group vs. intervention group vs. control group, 1/5 [20 %] vs. 2/9 [22.2 %] vs. 1/11 [9.1 %], p = 0.7).
  • CONCLUSIONS: Albumin administration shortens the duration of hospitalization for patients with peptic ulcer bleeding and hypoalbuminemia, but does not decrease the incidence of rebleeding.
  • [MeSH-major] Albumins / administration & dosage. Albumins / pharmacology. Hypoalbuminemia / drug therapy. Peptic Ulcer / pathology. Peptic Ulcer Hemorrhage / drug therapy

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  • [CommentIn] Dig Dis Sci. 2014 Feb;59(2):493 [24385010.001]
  • (PMID = 23934414.001).
  • [ISSN] 1573-2568
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins
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42. Jin GX, Li L, Cui SQ, Duan JZ, Wang H: Persistent hypoalbuminemia is a predictor of outcome in cervical spinal cord injury. Spine J; 2014 Sep 1;14(9):1902-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistent hypoalbuminemia is a predictor of outcome in cervical spinal cord injury.
  • BACKGROUND CONTEXT: Hypoalbuminemia is associated with increased morbidity and mortality in various clinical settings and several major diseases.
  • Albumin has multiple physiologic properties that could be beneficial in central nervous system injury.
  • PURPOSE: We sought to determine if albumin is associated with patient outcome after cervical spinal cord injury by conducting a retrospective analysis.
  • STUDY DESIGN/SETTING: A retrospective study of cervical spinal cord injury (CSCI) patients was conducted to investigate if serum albumin levels and other characteristics influence outcome (mechanical ventilation and death).
  • OUTCOME MEASURES: Demographic data were recorded, including age, gender, smoking history, time from injury to admission, severity of neurologic injury, neurologic level of lesion, mechanism of neurologic injury, Glasgow Coma Score, vitals in the Orthopedic Department, the occurrence of early surgical intervention (48 hours after injury), and daily serum albumin levels.
  • Serum albumin levels and other characteristics known to influence outcome were included in univariate statistical analyses and the multiple logistic regression model to analyze the relationship with mechanical ventilation and death after cervical injury.
  • Albumin remained lower than 30 g/L for a period of time (≥5 days) in patients with an unfavorable outcome (patients requiring mechanical ventilation or who had died).
  • Multiple logistic regression analysis identified age (>50 years), persistent hypoalbuminemia (<30 g/L and ≥5 days), C5 and above neurologic injury, and ASIA A as predictors for mechanical ventilation.
  • In addition, persistent hypoalbuminemia, ASIA A, and C4 and above neurologic injury were significantly associated with death.
  • CONCLUSION: Similar to the ASIA scale and neurologic level, persistent hypoalbuminemia seems to be an independent predictor of outcome in patients with CSCI.
  • Thus, a randomized trial assessing albumin in the treatment of cervical spinal cord injury is warranted.

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  • [Copyright] Copyright © 2014 Elsevier Inc. All rights reserved.
  • (PMID = 24252236.001).
  • [ISSN] 1878-1632
  • [Journal-full-title] The spine journal : official journal of the North American Spine Society
  • [ISO-abbreviation] Spine J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Albumin / Cervical spinal cord injury (CSCI) / Death / Edema / Hypoalbuminemia (HA) / Risk factor
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43. Wiedermann CJ, Wiedermann W, Joannidis M: Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies. Intensive Care Med; 2010 Oct;36(10):1657-65
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  • [Title] Hypoalbuminemia and acute kidney injury: a meta-analysis of observational clinical studies.
  • PURPOSE: To test the hypothesis that hypoalbuminemia is independently associated with increased risk of acute kidney injury (AKI).
  • METHODS: A meta-analysis was performed of observational clinical studies evaluating the relationship between serum albumin level and the occurrence of AKI by multivariate methods.
  • Additionally, the impact was assessed of lower serum albumin on mortality in patients who developed AKI.
  • RESULTS: Seventeen clinical studies with 3,917 total patients were included: 11 studies (6 in surgical or intensive care unit patients and 5 in other hospital settings) evaluating the influence of serum albumin on AKI incidence and 6 studies describing the relationship between serum albumin and mortality among patients who had developed AKI.
  • Lower serum albumin was an independent predictor both of AKI and of death after AKI development.
  • With each 10 g L(-1) serum albumin decrement, the odds of AKI increased by 134%.
  • Among patients who had developed AKI, the odds of death rose 147% (pooled OR 2.47, 95% CI 1.51-4.05) with each 10 g L(-1) serum albumin decrement.
  • CONCLUSIONS: This meta-analysis provides evidence that hypoalbuminemia is a significant independent predictor both of AKI and of death following AKI development.
  • Serum albumin determinations may be of utility in identifying patients at increased risk for AKI or for death after AKI.
  • Controlled studies are warranted to assess interventions aimed at correcting hypoalbuminemia.
  • [MeSH-major] Acute Kidney Injury / complications. Hypoalbuminemia / complications

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  • (PMID = 20517593.001).
  • [ISSN] 1432-1238
  • [Journal-full-title] Intensive care medicine
  • [ISO-abbreviation] Intensive Care Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Review
  • [Publication-country] United States
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44. Tada M, Yokoseki A, Sato T, Makifuchi T, Onodera O: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1. Adv Exp Med Biol; 2010;685:21-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early-onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1.
  • Significant attention has been given on the DNA SSB repair (SSBR) system in neurons, because the impairment of the SSBR causes human neurodegenerative disorders, including early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH), also known as ataxia-oculomotor apraxia Type 1 (AOA1).
  • EAOH/AOA1 is characterized by early-onset slowly progressive ataxia, ocular motor apraxia, peripheral neuropathy and hypoalbuminemia.
  • [MeSH-major] Apraxias. DNA Breaks, Single-Stranded. DNA Repair. DNA-Binding Proteins. Hypoalbuminemia. Nuclear Proteins. Spinocerebellar Degenerations

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  • (PMID = 20687492.001).
  • [ISSN] 0065-2598
  • [Journal-full-title] Advances in experimental medicine and biology
  • [ISO-abbreviation] Adv. Exp. Med. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / APTX protein, human; 0 / DNA-Binding Proteins; 0 / Mutagens; 0 / Nuclear Proteins; 0 / X-ray repair cross complementing protein 1
  • [Number-of-references] 87
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45. Baldwin MR, Arcasoy SM, Shah A, Schulze PC, Sze J, Sonett JR, Lederer DJ: Hypoalbuminemia and early mortality after lung transplantation: a cohort study. Am J Transplant; 2012 May;12(5):1256-67
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  • [Title] Hypoalbuminemia and early mortality after lung transplantation: a cohort study.
  • Hypoalbuminemia predicts disability and mortality in patients with various illnesses and in the elderly.
  • The association between serum albumin concentration at the time of listing for lung transplantation and the rate of death after lung transplantation is unknown.
  • We used Cox proportional hazard models and generalized additive models to examine multivariable-adjusted associations between serum albumin and the rate of death after transplantation.
  • Those with severe (0.5-2.9 g/dL) and mild hypoalbuminemia (3.0-3.6 g/dL) had posttransplant adjusted mortality rate ratios of 1.35 (95% CI: 1.12-1.62) and 1.15 (95% CI: 1.04-1.27), respectively.
  • For each 0.5 g/dL decrease in serum albumin concentration the 1-year and overall mortality rate ratios were 1.48 (95% CI: 1.21-1.81) and 1.26 (95% CI: 1.11-1.43), respectively.
  • The association between hypoalbuminemia and posttransplant mortality was strongest in recipients with cystic fibrosis and interstitial lung disease.
  • Hypoalbuminemia is an independent risk factor for death after lung transplantation.
  • [MeSH-major] Hypoalbuminemia / etiology. Hypoalbuminemia / mortality. Lung Transplantation / adverse effects. Lung Transplantation / mortality. Postoperative Complications. Serum Albumin / deficiency

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  • [Copyright] © Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
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  • (PMID = 22335491.001).
  • [ISSN] 1600-6143
  • [Journal-full-title] American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • [ISO-abbreviation] Am. J. Transplant.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K23 HL086714; United States / NHLBI NIH HHS / HL / K23HL086714; United States / NHLBI NIH HHS / HL / R01 HL103676; United States / NCRR NIH HHS / RR / UL1 RR024156
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Serum Albumin
  • [Other-IDs] NLM/ NIHMS451807; NLM/ PMC3628840
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46. Estrella EP, Lee EY: A retrospective, descriptive study of sacral ulcer flap coverage in nonambulatory patients with hypoalbuminemia. Ostomy Wound Manage; 2010 Mar 1;56(3):52-9
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  • [Title] A retrospective, descriptive study of sacral ulcer flap coverage in nonambulatory patients with hypoalbuminemia.
  • Reports about the effects of protein status on postoperative healing are inconsistent but surgery often is delayed until serum albumin levels normalize.
  • A retrospective chart review was conducted to evaluate clinical outcomes of 16 nonambulatory patients (10 men, 6 women; average age 54 years, range 18 to 74) with moderate to severe hypoalbuminemia who underwent flap surgery for coverage of their Stage III or Stage IV sacral ulcers within a protocol of interdisciplinary care.
  • Patient average albumin level before flap coverage was 21 g/L (range: 8 to 30 g/L), average sacral ulcer size was 10 cm x 10 cm, patients underwent an average of 2.56 procedures to achieve coverage, and average follow-up period was 11.25 months (range: 3 to 33 months, SD +/- 10.4) after surgical closure.
  • Results suggest that with a system of interdisciplinary care and collaboration, sacral ulcer flap surgery can be performed in patients with moderate to severe hypoalbuminemia.

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  • (PMID = 20368674.001).
  • [ISSN] 1943-2720
  • [Journal-full-title] Ostomy/wound management
  • [ISO-abbreviation] Ostomy Wound Manage
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins
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47. Tanaka T, Komasawa N, Kataiwa M, Hashimoto T, Ohue M, Minami T: [Successful use of "juzen-taiho-to", a kampo medicine, for the treatment of perioperative anemia and hypoalbuminemia]. Masui; 2014 Aug;63(8):924-6
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  • [Title] [Successful use of "juzen-taiho-to", a kampo medicine, for the treatment of perioperative anemia and hypoalbuminemia].
  • Surgery was performed under general anesthesia, and the following day, anemia (hemoglobin, 7.5 g x dl(-1)) and hypoalbuminemia (albumin, 2.7 g x dl(-1)) were observed, in addition to anorexia and general fatigue.
  • On the 18th day after admission, anemia (hemoglobin, 8.9 g x dl(-1)) and hypoalbuminemia (3.6 g x dl(-1)) improved, as did anorexia and general fatigue.
  • It is thought that the components Shimotsu-to, a component known to improve anemia, and Shikunshi-to, a vital energy supplementing component, were the main ingredients that conferred the improvements in anemia and hypoalbuminemia.
  • [MeSH-major] Anemia / drug therapy. Anesthesia, General. Drugs, Chinese Herbal / therapeutic use. Femoral Neck Fractures / surgery. Hypoalbuminemia / drug therapy. Phytotherapy. Postoperative Complications / drug therapy


48. Braier JL, Rosso D, Latella A, Chantada G, Ozuna B, Ripoli M, Scopinaro M: Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with "risk-organ" multi-system Langerhans cell histiocytosis. J Pediatr Hematol Oncol; 2010 May;32(4):e122-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance of multi-lineage hematologic involvement and hypoalbuminemia at diagnosis in patients with "risk-organ" multi-system Langerhans cell histiocytosis.
  • AIM: To perform a risk factor analysis in patients with "risk organ" multi-system Langerhans cell histiocytosis at diagnosis.
  • A univariate analysis of the variables, age <2 years, lungs, spleen and hepatic involvement, presence of >or=2 risk involved organs, hypoalbuminemia and the presence of isolated anemia, anemia with thrombocytopenia with or without leukopenia at diagnosis was performed.
  • RESULTS: Fifty-six and 66 evaluable patients had hematologic and hepatic involvement at diagnosis, respectively.
  • Of all the patients, those with hypoalbuminemia had a 5-year survival of 0.16 compared with those with normal albumin levels, who had a 5-year survival of 0.65 (P<0.0001).
  • In multivariate analysis, only anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia were the independent risk factors (relative risk 3.77; confidence interval, 1.7-8.4; P<0.0011 and relative risk 2.59; confidence interval, 1.24-5.4; P<0.0112).
  • CONCLUSIONS: Anemia with thrombocytopenia with or without leukopenia and hypoalbuminemia, were associated with worse prognosis in multi-system Langerhans cell histiocytosis.
  • Other therapeutic strategies should be considered at diagnosis or early during the initial treatment for this high risk subgroup of patients.
  • [MeSH-major] Anemia / pathology. Cell Lineage. Histiocytosis, Langerhans-Cell / diagnosis. Hypoalbuminemia / pathology. Leukopenia / pathology. Thrombocytopenia / pathology


49. Miwa A, Morioka I, Hisamatsu C, Fujioka K, Morikawa S, Shibata A, Yasufuku M, Yokoyama N, Matsuo M: Hypoalbuminemia following abdominal surgery leads to high serum unbound bilirubin concentrations in newborns soon after birth. Neonatology; 2011;99(3):202-7
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  • [Title] Hypoalbuminemia following abdominal surgery leads to high serum unbound bilirubin concentrations in newborns soon after birth.
  • BACKGROUND: The serum concentration of unbound bilirubin (UB), which is bilirubin not bound to albumin (Alb), is a better index than total bilirubin concentration (TB) for identifying infants at risk for developing bilirubin neurotoxicity.
  • The degree to which the hypoalbuminemia following abdominal surgery in jaundiced newborns affects bilirubin binding is unknown.
  • OBJECTIVE: To determine whether lower Alb occurring in newborns undergoing abdominal surgery shortly after birth results in significantly higher UB in serum versus nonsurgical patients at comparable serum TB.
  • Clinical and laboratory data (serum UB, TB, and Alb concentrations, UB/TB ratio, and binding constant) in the surgery group were collected and compared with those of 30 control newborns who did not undergo abdominal surgery (control group).
  • RESULTS: Serum UB and the UB/TB ratio in the surgery group were significantly higher than those in the control group (p < 0.02, p < 0.001, respectively), whereas there were no significant differences in serum TB and binding constant between the groups.
  • Serum Alb concentrations in the surgery group were significantly lower than those in the control group (p < 0.001).
  • When pre- and postoperative serum Alb concentrations were compared, there was a significant decrease from 3.4 to 2.7 g/dl (p < 0.001).
  • CONCLUSIONS: Our study suggests that hypoalbuminemia following abdominal surgery causes a higher serum UB at comparable serum TB in newborns.
  • [MeSH-major] Bilirubin / blood. Digestive System Surgical Procedures / adverse effects. Hypoalbuminemia / blood. Infant, Newborn / blood

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20881436.001).
  • [ISSN] 1661-7819
  • [Journal-full-title] Neonatology
  • [ISO-abbreviation] Neonatology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] RFM9X3LJ49 / Bilirubin
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50. Dao CN, Peters PJ, Kiarie JN, Zulu I, Muiruri P, Ong'ech J, Mutsotso W, Potter D, Njobvu L, Stringer JS, Borkowf CB, Bolu O, Weidle PJ: Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan women. AIDS Res Hum Retroviruses; 2011 Nov;27(11):1149-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan women.
  • We examined whether serum chemistries at ART initiation predicted mortality among HIV-infected women.
  • Women were more likely to die if they were both hyponatremic (sodium <135 mmol/liter) and hypochloremic (chloride <95 mmol/liter) (37% vs. 6%) or hypoalbuminemic (albumin <34 g/liter, 13% vs. 4%) when initiating ART.
  • A body mass index <18 kg/m(2) [adjusted hazard ratio (aHR) 5.3, 95% confidence interval (CI) 2.6-10.6] and hyponatremia with hypochloremia (aHR 4.5, 95% CI 2.2-9.4) were associated with 1-year mortality after adjusting for country, CD4 cell count, WHO clinical stage, hemoglobin, and albumin.
  • Among women with a CD4 cell count >50 cells/μl, hypoalbuminemia was also a significant predictor of mortality (aHR=3.7, 95% CI 1.4-9.8).
  • Baseline hyponatremia with hypochloremia and hypoalbuminemia predicted mortality in the first year of initiating ART, and these abnormalities might reflect opportunistic infections (e.g., tuberculosis) or advanced HIV disease.
  • Assessment of serum sodium, chloride, and albumin can identify HIV-infected patients at highest risk for mortality who may benefit from more intensive medical management during the first year of ART.
  • [MeSH-major] Anti-HIV Agents / therapeutic use. Chlorides / blood. HIV Infections / mortality. Hypoalbuminemia / diagnosis. Hyponatremia / diagnosis. Reverse Transcriptase Inhibitors / therapeutic use. Survival Analysis
  • [MeSH-minor] Adult. Cause of Death. Cohort Studies. Female. Humans. Kenya / epidemiology. Predictive Value of Tests. Proportional Hazards Models. Prospective Studies. Risk Factors. Serum Albumin. Sodium / blood. Treatment Outcome. Zambia / epidemiology

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  • (PMID = 21417949.001).
  • [ISSN] 1931-8405
  • [Journal-full-title] AIDS research and human retroviruses
  • [ISO-abbreviation] AIDS Res. Hum. Retroviruses
  • [Language] eng
  • [Grant] United States / PHS HHS / / U62/CCU024526; United States / PHS HHS / / U62/CCU12354
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-HIV Agents; 0 / Chlorides; 0 / Reverse Transcriptase Inhibitors; 0 / Serum Albumin; 9NEZ333N27 / Sodium
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