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1. Biomedical articles (top 50; 2008 to 2013)

1. |||||||||. 100%  George TI: Malignant or benign leukocytosis. Hematology Am Soc Hematol Educ Program; 2012;2012:475-84

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Malignant or benign leukocytosis.

Leukocytosis, or elevated WBC count, is a commonly encountered laboratory finding.

Distinguishing malignant from benign leukocytosis is a critical step in the care of a patient, which initiates a vastly different decision tree.

Confirmation of the complete blood cell count and the WBC differential is the first step.

Examination of the PB smear is essential to confirming the automated blood cell differential or affirming the manual differential performed on the PB smear.

Next is separation of the leukocytosis into a myeloid versus a lymphoid process.

Distinguishing a reactive lymphoid proliferation from a lymphoproliferative disorder requires examination of lymphocyte morphology for pleomorphic lymphocytes versus a monomorphic population, with the latter favoring a lymphoproliferative neoplasm.

Myeloid leukocytosis triggers a differential diagnosis of myeloid leukemoid reactions versus myeloid malignancies.

Myeloid leukemoid reactions commonly result from infections and show activated neutrophil changes on morphology; these should prompt evaluation for infection.

Other causes of reactive myeloid leukocytoses are also discussed herein.

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(PMID = 23233622.001).

[ISSN] 1520-4383

[Journal-full-title] Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program

[ISO-abbreviation] Hematology Am Soc Hematol Educ Program

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

2. ||||||||.. 78%  Worley MJ Jr, Nitschmann CC, Shoni M, Vitonis AF, Rauh-Hain JA, Feltmate CM: The significance of preoperative leukocytosis in endometrial carcinoma. Gynecol Oncol; 2012 Jun;125(3):561-5

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] The significance of preoperative leukocytosis in endometrial carcinoma.

OBJECTIVE: To evaluate the impact of preoperative leukocytosis among patients with endometrial carcinoma.

Patients were separated into two groups based on the presence or absence of preoperative leukocytosis (WBC ≥ 10,000 cells per μl).

RESULTS: 1144 patients were identified, 156 (13.6%) with preoperative leukocytosis and 988 (86.4%) without leukocytosis.

The leukocytosis group had a greater percentage of patients with stage 3 (15.4% vs. 9.8%, crude p=0.02) and 4 (7.1% vs. 3.0%, crude p=0.007) disease.

Leukocytosis was associated with a greater mean tumor size (4.4 vs. 3.4 cm, p=0.0002) and a greater percentage of patients with cervical stromal involvement (14.8% vs. 8.7%, crude p=0.02), adnexal involvement (14.1% vs. 7.5%, crude p=0.007) and lymphvascular space invasion (24% vs. 16.3%, crude p=0.02).

On multivariate analysis, mean tumor size (OR, 95% CI; 1.10, 1.02-1.18) remained significantly associated with preoperative leukocytosis.

However, leukocytosis was independently associated with an increased risk of death (HR, 95% CI; 1.69, 1.07-2.68).

CONCLUSIONS: Preoperative leukocytosis, among endometrial cancer patients, was independently associated with increasing tumor size and independently imposed an increased risk of death.

[MeSH-major] Endometrial Neoplasms / blood. Endometrial Neoplasms / surgery. Leukocytosis / complications

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[Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.

(PMID = 22465698.001).

[ISSN] 1095-6859

[Journal-full-title] Gynecologic oncology

[ISO-abbreviation] Gynecol. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

3. ||||||||.. 77%  Kuznik BI, Morozova IIu, Rodnina OS, Strambovskaia NN, Shirshov IuA: [Leukocytosis and outcomes of acute stroke]. Zh Nevrol Psikhiatr Im S S Korsakova; 2010;110(3):10-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Leukocytosis and outcomes of acute stroke].

We carried out the retrospective analysis of 300 disease histories of patients with stroke hospitalized in the first 24 h of the disease.

The presence of leukocytosis and its severity were evaluated as predictors of outcome.

The level of leukocyte-erythrocyte aggregations in the blood film was determined in some patients.

The analysis revealed that the higher was leukocytosis, the more severe was the course of stroke and the higher was frequency of fatal outcomes.

Patients with stroke more often had neutrophilic leukocytosis than monocytosis, the former was the predictor of worse prognosis.

The most unfavorable prognosis was observed in patients with hemorrhagic stroke and leukocytosis.

The higher was the number of leukocytes, the higher was the probability of fatal outcome in the first month of stroke.

The level of leukocyte-erythrocyte aggregations dramatically increased in the blood of stroke patients that promoted the disturbance of microcirculation and worsened significantly the disease prognosis.

[MeSH-major] Leukocytosis / blood. Leukocytosis / etiology. Stroke / blood. Stroke / mortality

[MeSH-minor] Female. Humans. Leukocyte Count. Male. Monocytes. Neutrophils. Prognosis. Retrospective Studies

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(PMID = 20517219.001).

[ISSN] 1997-7298

[Journal-full-title] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov

[ISO-abbreviation] Zh Nevrol Psikhiatr Im S S Korsakova

[Language] rus

[Publication-type] English Abstract; Journal Article

[Publication-country] Russia (Federation)

   

4. |||||||... 72%  Marchetti M, Falanga A: Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders. Pathophysiol Haemost Thromb; 2008;36(3-4):148-59

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis, JAK2V617F mutation, and hemostasis in myeloproliferative disorders.

Thrombosis is a leading cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV).

Several mechanisms have been proposed to cause or to contribute to the acquired thrombophilic state of these patients, including platelet and red blood cell abnormalities.

The increase in white blood cell count, found in most subjects with these disorders, raises the possibility that circulating leukocytes may represent another prothrombotic factor, as demonstrated for other conditions, including sickle cell, coronary heart, and peripheral arterial diseases.

Published data demonstrate that neutrophil activation occurs in ET and PV patients in parallel with the appearance of laboratory signs of hemostatic system activation, suggesting an involvement of these cells in the pathogenesis of the thrombotic predisposition of these subjects.

Retrospective data have identified JAK2(V617F) as a risk factor for thrombosis in ET, and have also shown a close association with abdominal vein thrombosis.

JAK2(V617F) is variably associated with thrombosis and, more consistently, with elevations in blood cell counts.

A clear link appears to exist between leukocytosis, JAK2(V617F), and the hemostatic system activation in patients with Bcl-negative myeloproliferative disorders.

[MeSH-major] Hemostasis / genetics. Janus Kinase 2 / genetics. Leukocytosis / genetics. Mutation, Missense. Myeloproliferative Disorders / genetics. Point Mutation. Thrombophilia / genetics

[MeSH-minor] Amino Acid Substitution. Cytokines / physiology. Endothelium, Vascular / physiopathology. Enzyme Activation. Female. Humans. Inflammation / blood. Inflammation / genetics. Inflammation / physiopathology. Leukocyte Elastase / physiology. Male. Models, Biological. Neutrophils / enzymology. Neutrophils / physiology. Platelet Activation. Pregnancy. Pregnancy Complications, Hematologic / genetics. Retrospective Studies. Risk Factors. Venous Thrombosis / enzymology. Venous Thrombosis / etiology

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[Copyright] Copyright 2009 S. Karger AG, Basel.

(PMID = 19176988.001).

[ISSN] 1424-8840

[Journal-full-title] Pathophysiology of haemostasis and thrombosis

[ISO-abbreviation] Pathophysiol. Haemost. Thromb.

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Cytokines; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2; EC 3.4.21.37 / Leukocyte Elastase

[Number-of-references] 70

   

5. |||||||... 66%  Cerny J, Rosmarin AG: Why does my patient have leukocytosis? Hematol Oncol Clin North Am; 2012 Apr;26(2):303-19, viii

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Why does my patient have leukocytosis?

Leukocytosis is one of the most common laboratory abnormalities in medicine, and one of the most frequent reasons for hematologic consultation.

Effective evaluation of leukocytosis requires an attentive history, careful physical examination, meticulous review of the complete blood count and peripheral blood smear, judicious application of laboratory and radiologic testing, and thoughtful analysis.

Definitive diagnosis may require bone marrow aspiration and biopsy, imaging studies, and specialized molecular tests.

The differential diagnosis of leukocytosis includes physiologic responses to a broad range of infectious and inflammatory processes, as well as numerous primary hematologic disorders such as leukemias, lymphomas, and myeloproliferative neoplasms.

[MeSH-major] Leukocytosis / etiology

[MeSH-minor] Cell Differentiation. Humans. Leukocytes / cytology. Leukocytes / metabolism

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[Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.

(PMID = 22463829.001).

[ISSN] 1558-1977

[Journal-full-title] Hematology/oncology clinics of North America

[ISO-abbreviation] Hematol. Oncol. Clin. North Am.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

   

6. |||||||... 65%  Sopko MA, Caley CF: Chronic leukocytosis associated with clozapine treatment. Clin Schizophr Relat Psychoses; 2010 Jul;4(2):141-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Chronic leukocytosis associated with clozapine treatment.

Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns.

Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC).

In some of these patients, the leukocytosis may be persistent.

We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis.

A brief review of the literature addressing clozapine-associated leukocytosis follows the case report.

[MeSH-major] Antipsychotic Agents / adverse effects. Clozapine / adverse effects. Leukocytosis / chemically induced. Schizophrenia, Paranoid / drug therapy

[MeSH-minor] Adult. Chronic Disease. Dose-Response Relationship, Drug. Drug Therapy, Combination. Humans. Leukocyte Count. Male

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(PMID = 20643637.001).

[ISSN] 1935-1232

[Journal-full-title] Clinical schizophrenia & related psychoses

[ISO-abbreviation] Clin Schizophr Relat Psychoses

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antipsychotic Agents; 5786-21-0 / Clozapine

   

7. ||||||.... 65%  Kondoh E, Shimizu M, Kakui K, Mikami Y, Tatsumi K, Konishi I: Deciduosis can cause remarkable leukocytosis and obscure abdominal pain. J Obstet Gynaecol Res; 2012 Dec;38(12):1376-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Deciduosis can cause remarkable leukocytosis and obscure abdominal pain.

Remarkable leukocytosis with obscure abdominal pain during pregnancy is clinically challenging for obstetricians.

A 31-year-old pregnant woman developed persistently elevated white blood cell (approximately 30 000/µL) and C-reactive protein (3.0 mg/dL) with occasional moderate abdominal pain.

White blood cells rose 87200/µL, and C-reactive protein peaked at 44.9mg/dL after surgery.

Pathologically, biopsies showed deciduosis, and decidual cells on the omental surface showed immunohistochemical staining for granulocyte colony-stimulating factor (G-CSF).

G-CSF-producing deciduosis can induce leukocytosis as well as abdominal pain during pregnancy and postpartum.

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[Copyright] © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

(PMID = 22612308.001).

[ISSN] 1447-0756

[Journal-full-title] The journal of obstetrics and gynaecology research

[ISO-abbreviation] J. Obstet. Gynaecol. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Australia

   

8. ||||||.... 64%  Ishii T, Sakamoto A, Matsuda S, Matsumoto Y, Harimaya K, Takahashi Y, Oda Y, Iwamoto Y: Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF. Skeletal Radiol; 2012 Jun;41(6):719-23

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF.

Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors.

Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection.

A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically.

Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors.

[MeSH-major] Bone Neoplasms / diagnosis. Granulocyte Colony-Stimulating Factor / blood. Humerus / pathology. Leiomyosarcoma / diagnosis. Leukocytosis / blood. Leukocytosis / diagnosis

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(PMID = 22167228.001).

[ISSN] 1432-2161

[Journal-full-title] Skeletal radiology

[ISO-abbreviation] Skeletal Radiol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Germany

[Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor

   

9. ||||||.... 62%  Furer V, Raveh D, Picard E, Goldberg S, Izbicki G: Absence of leukocytosis in bacteraemic pneumococcal pneumonia. Prim Care Respir J; 2011 Sep;20(3):276-81

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Absence of leukocytosis in bacteraemic pneumococcal pneumonia.

BACKGROUND: Evaluation of patients with respiratory symptoms in primary care medicine is often based on peripheral WBC count that dictates the extent of diagnostic investigation.

A normal WBC count may result in a limited investigation, often omitting chest radiography.

AIMS: To determine the extent to which patients hospitalised with bacteraemic pneumococcal pneumonia have no leukocytosis at presentation.

RESULTS: 21% of the patients presented with a normal WBC count (16.7% of the children and 25.6% of the adults).

Among this population with a normal WBC count at presentation, 90% of the adults and 70% of the children developed leukocytosis within a few days after admission.

CONCLUSIONS: In this study, in as many as one-fifth of all the patients with bacteraemic pneumococcal pneumonia, there was no leukocytosis at presentation.

We therefore suggest that every patient with clinically suspected pneumonia should undergo chest radiography even if the WBC count is normal.

[MeSH-major] Bacteremia / blood. Bacteremia / diagnosis. Pneumonia, Pneumococcal / blood. Pneumonia, Pneumococcal / diagnosis

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Community-Acquired Infections / blood. Community-Acquired Infections / complications. Female. Humans. Infant. Leukocytosis / complications. Leukocytosis / epidemiology. Male. Middle Aged. Retrospective Studies. Young Adult

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(PMID = 21509416.001).

[ISSN] 1475-1534

[Journal-full-title] Primary care respiratory journal : journal of the General Practice Airways Group

[ISO-abbreviation] Prim Care Respir J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

10. ||||||.... 62%  Carobbio A, Finazzi G, Antonioli E, Guglielmelli P, Vannucchi AM, Delaini F, Guerini V, Ruggeri M, Rodeghiero F, Rambaldi A, Barbui T: Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. Blood; 2008 Oct 15;112(8):3135-7

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia.

To elucidate the role of thrombocytosis, alone or in combination with standard (age, previous cardiovascular events) and novel (leukocytosis, JAK2(V617F) mutational status) risk factors, in the cardiovascular events of essential thrombocythemia (ET), we analyzed a cohort of 1063 patients.

We found that a platelet count at diagnosis greater than 1000 x 10(9)/L was associated with significantly lower rate of thrombosis in multivariable analysis and, if combined with leukocytes less than 11 x 10(9)/L, pointed to a "low-risk" category with a rate of thrombosis of 1.59% of patients/year.

On the contrary, the highest risk category (thrombosis rate, 2.95% of patients/year) was constituted of patients with leukocytosis, lower platelet count, and a JAK2(V617F) mutated genotype in most cases (77% vs 26% in the low-risk group), independently from standard risk factors.

These data challenge the theory that elevated platelet count increases thrombosis risk in ET and suggest prospective clinical trials to support this hypothesis.

[MeSH-major] Leukocytosis / diagnosis. Thrombocythemia, Essential / complications. Thrombocythemia, Essential / diagnosis. Thrombocytosis / diagnosis

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Cohort Studies. DNA Mutational Analysis. Female. Humans. Leukocytes / cytology. Male. Middle Aged. Platelet Count. Risk Factors

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[Cites] N Engl J Med. 2005 Jul 7;353(1):33-45 [16000354.001]

[Cites] N Engl J Med. 2005 Jul 7;353(1):85-6 [16000360.001]

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[CommentIn] Blood. 2008 Oct 15;112(8):3526; author reply 3526-7 [18840727.001]

(PMID = 18587010.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ PMC2569168

   

11. ||||||.... 61%  Munoz J, Guo Y: Leukocytosis: The mysteries within. Am J Hematol; 2012 Feb;87(2):197

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis: The mysteries within.

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(PMID = 21815181.001).

[ISSN] 1096-8652

[Journal-full-title] American journal of hematology

[ISO-abbreviation] Am. J. Hematol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

12. ||||||.... 55%  Worley MJ Jr, Nitschmann CC, Shoni M, Rauh-Hain JA, Williams KA, Feltmate CM: Preoperative leukocytosis imposes an increased risk of recurrence and death among patients with nonendometrioid endometrial carcinoma. Int J Gynecol Cancer; 2013 Feb;23(2):312-7

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Preoperative leukocytosis imposes an increased risk of recurrence and death among patients with nonendometrioid endometrial carcinoma.

OBJECTIVE: To evaluate the impact of preoperative leukocytosis among patients with nonendometrioid endometrial carcinoma.

The patients were separated into 2 groups based on the presence or absence of preoperative leukocytosis (white blood cell count ≥ 10,000/μL).

RESULTS: A total of 222 patients were identified, and preoperative leukocytosis was observed in 33 patients (14.9%).

The leukocytosis group was associated with a larger mean size of the primary tumor (6.8 vs 4.6 cm, P = 0.016) and a greater percentage of patients with cervical stromal involvement (36.4% vs 20.1%, P = 0.039), adnexal involvement (42.4% vs. 22.8%, P = 0.017), and pelvic/para-aortic lymph node involvement (50% vs 27.4%, P = 0.025).

On multivariate analysis, preoperative leukocytosis was independently associated with an increased risk of recurrence (hazard ratio, 2.07; 95% confidence interval, 1.12-3.84) and an increased risk of death (hazard ratio, 3.33; 95% confidence interval, 2.01-5.53).

CONCLUSIONS: Among patients with nonendometrioid endometrial carcinoma, preoperative leukocytosis is independently associated with an increased risk of recurrence and death.

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(PMID = 23358179.001).

[ISSN] 1525-1438

[Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

[ISO-abbreviation] Int. J. Gynecol. Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

13. |||||..... 55%  Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH: Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy. Thromb Res; 2010 Aug;126(2):113-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy.

BACKGROUND: Leukocytosis has been associated with thrombosis and mortality in cancer patients.

We explored the association of leukocytosis with venous thromboembolism (VTE) and early mortality in cancer patients initiating chemotherapy.

The association of leukocytosis, VTE and mortality during the course of chemotherapy was evaluated in univariate and multivariate analysis.

Of 4391 patients with available baseline white blood cell (WBC) count, 561 (12.8%) had elevated pretreatment leukocyte counts, defined as WBC > 11 x 10(9) cells/L.

VTE occurred in 25 of 561 patients (4.5%) with baseline leukocytosis compared to 68 of 3830 (1.8%) with WBC <or= 11 x 10(9) cells/L (P < 0.0001).

Baseline leukocytosis was associated with VTE by multivariate analysis as well (HR 2.1, 95% confidence interval 1.3-3.4, p = 0.003).

Forty one patients (7.3%) with leukocytosis died compared to 92 (2.4%) with WBC <or= 11 x 10(9) cells/L (P < 0.0001).

Baseline leukocytosis was associated with early mortality by multivariate analysis as well (HR 2.2, 95% confidence interval 1.5-3.3, p < 0.0001).

Mortality was greatest in patients with both leukocytosis and VTE.

In multivariate analysis several factors were predictive of leukocytosis.

CONCLUSIONS: Elevated WBC, particularly neutrophils, is strongly associated with increased risk of VTE and mortality in cancer patients receiving systemic chemotherapy.

[MeSH-major] Leukocytosis / complications. Neoplasms / complications. Neoplasms / drug therapy. Venous Thromboembolism / complications

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[Copyright] (c) 2010 Elsevier Ltd. All rights reserved.

[CommentIn] Thromb Res. 2011 May;127(5):487; author reply 488 [21185587.001]

(PMID = 20684071.001).

[ISSN] 1879-2472

[Journal-full-title] Thrombosis research

[ISO-abbreviation] Thromb. Res.

[Language] eng

[Grant] United States / NHLBI NIH HHS / HL / 1R01HL095109-01; United States / NCI NIH HHS / CA / K23 CA120587-01; United States / NHLBI NIH HHS / HL / R01 HL095109; United States / NCI NIH HHS / CA / UC2 CA148041

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ NIHMS453607; NLM/ PMC3635827

   

14. |||||..... 54%  Asadollahi K, Hastings IM, Beeching NJ, Gill GV, Asadollahi P: Leukocytosis as an alarming sign for mortality in patients hospitalized in general wards. Iran J Med Sci; 2011 Mar;36(1):45-9

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis as an alarming sign for mortality in patients hospitalized in general wards.

There is some evidence that leukocytosis without infection is associated with increased hospital mortality, but data in this regard are very incomplete.

This study was designed to investigate the relationship between leukocytosis at the time of admission and mortality among patients hospitalized in general wards.

During July to Nov 2004, all deceased patients who had a white blood cell (WBC) count record for the first 24 hours of admission were selected as cases.

Among survivors, twice the number of cases was selected as controls.

Different levels of WBC counts were compared between cases and controls.

The median WBC for deceased and surviving patients was 9.4 and 11.4×10(9)/l, respectively.

Patients with a WBC >10×10(9)/l accounted for 804, among which 335 (42%) were deceased.

Leukocytosis and leukopoenia were more frequent among the deceased patients compared to the survivors.

The likelihood ratio for leukocytosis and leukopenia among the cases and controls was 1.4 and 2.3, respectively.

Leukocytosis was identified as an alarming sign for mortality among patients admitted to general hospital wards at early stages of admission.

A quick medical intervention for amendment of the causes related to leukocytosis should consequently reduce hospital mortality.

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[Cites] Am J Cardiol. 2001 Mar 1;87(5):636-9, A10 [11230853.001]

[Cites] World J Surg. 2001 Jun;25(6):739-44 [11376409.001]

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(PMID = 23365478.001).

[ISSN] 0253-0716

[Journal-full-title] Iranian journal of medical sciences

[ISO-abbreviation] Iran J Med Sci

[Language] eng

[Publication-type] Journal Article

[Publication-country] Iran

[Other-IDs] NLM/ PMC3559113

   

15. |||||..... 54%  Golob JF Jr, Claridge JA, Sando MJ, Phipps WR, Yowler CJ, Fadlalla AM, Malangoni MA: Fever and leukocytosis in critically ill trauma patients: it's not the urine. Surg Infect (Larchmt); 2008 Feb;9(1):49-56

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Fever and leukocytosis in critically ill trauma patients: it's not the urine.

Therefore, fever and leukocytosis often trigger an extensive laboratory workup that includes a urine culture (UCx).

1) Define the current practice for obtaining UCxs in trauma patients admitted to the surgical and trauma intensive care unit (STICU); and 2) determine if there is an association between fever or leukocytosis and urinary tract infections (UTIs) during the initial 14 hospital days.

Data collected included demographics, injuries, and daily maximal temperature (T(max)), leukocyte count, and UCx results for the first 14 days.

Fever and leukocytosis were defined as T(max) > or =38.5 degrees C and leukocyte count > or =12,000/mm(3), respectively.

There was a significant association between obtaining a UCx and fever and between fever and leukocytosis (both, p < 0.001), but no association of UTI with fever, leukocytosis, or the combination of fever and leukocytosis.

Analysis using temperature and leukocyte count as continuous variables identified no temperature or leukocyte range associated with UTIs.

CONCLUSIONS: The practice of obtaining a UCx from the STICU trauma patient was related to fever and fever with leukocytosis.

However, neither fever nor leukocytosis nor both were associated with UTIs.

These data suggest that there is an unnecessary emphasis on UTI as a source of fever and leukocytosis in injured patients during their first 14 STICU days.

[MeSH-major] Critical Illness. Fever / etiology. Leukocytosis / etiology. Urinary Tract Infections / physiopathology. Wounds and Injuries / complications

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(PMID = 18363468.001).

[ISSN] 1096-2964

[Journal-full-title] Surgical infections

[ISO-abbreviation] Surg Infect (Larchmt)

[Language] eng

[Grant] United States / NCRR NIH HHS / RR / 1KL2RR024990; United States / NCRR NIH HHS / RR / KL2 RR024990

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] United States

   

16. |||||..... 54%  Lee F, Yu MC: Association between peritoneal dialysate effluent leukocytosis and amlodipine besylate. Am J Kidney Dis; 2009 Mar;53(3):e1-3

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Association between peritoneal dialysate effluent leukocytosis and amlodipine besylate.

Dialysate effluent leukocytosis is consistent with a greater degree of infection or inflammation in patients receiving peritoneal dialysis.

This study describes a girl aged 2 years 9 months with end-stage renal disease resulting from crescent glomerulonephritis and severe interstitial nephritis who developed leukocytosis with a predominance of lymphocytes in the dialysate effluent, and in whom the effluent cell count normalized 1 week after discontinuation of amlodipine besylate therapy.

Rechallenge confirmed that amlodipine was the offending agent causing effluent leukocytosis.

[MeSH-major] Amlodipine / adverse effects. Calcium Channel Blockers / adverse effects. Dialysis Solutions. Kidney Failure, Chronic / complications. Kidney Failure, Chronic / therapy. Leukocytosis / chemically induced. Peritoneal Dialysis, Continuous Ambulatory

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(PMID = 19167800.001).

[ISSN] 1523-6838

[Journal-full-title] American journal of kidney diseases : the official journal of the National Kidney Foundation

[ISO-abbreviation] Am. J. Kidney Dis.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Calcium Channel Blockers; 0 / Dialysis Solutions; 88150-42-9 / Amlodipine

   

17. |||||..... 53%  Claridge JA, Golob JF Jr, Fadlalla AM, Malangoni MA, Blatnik J, Yowler CJ: Fever and leukocytosis in critically ill trauma patients: it is not the blood. Am Surg; 2009 May;75(5):405-10

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Fever and leukocytosis in critically ill trauma patients: it is not the blood.

The diagnosis of bacteremia in critically ill patients is classically based on fever and/or leukocytosis.

The objectives of this study were to determine 1) if our intensive care unit obtains blood cultures based on fever and/or leukocytosis over the initial 14 days of hospitalization after trauma; and 2) the efficacy of this diagnostic workup.

Data collected included demographics, injuries, and the first 14 days maximal daily temperature, leukocyte count, and results of blood and catheter tip cultures.

Fever was defined as a maximum daily temperature of 38.5 degrees C or greater and leukocytosis as a leukocyte count 12,000/mm3 or greater of blood.

Four hundred twenty-five blood culture episodes were obtained and 25 (6%) bacteremias were identified in 23 patients (5%).

A significant association was found between obtaining blood cultures in patients with fever (relative risk [RR], 7.7), leukocytosis (RR, 1.3), and fever + leukocytosis (RR, 3.2).

However, no significant association was found between these clinical signs and the diagnosis of bacteremia.

Our intensive care unit follows the common "fever workup" practice and obtains blood cultures based on the presence of fever and leukocytosis.

However, fever and leukocytosis were not associated with bacteremia, suggesting inefficiency and that other factors are more important after trauma.

[MeSH-major] Bacteremia / microbiology. Critical Illness. Fever / etiology. Leukocytosis / etiology. Wounds and Injuries / complications

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(PMID = 19445292.001).

[ISSN] 0003-1348

[Journal-full-title] The American surgeon

[ISO-abbreviation] Am Surg

[Language] eng

[Grant] United States / NCRR NIH HHS / RR / 1KL2RR024990; United States / NCRR NIH HHS / RR / KL2 RR024990

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

   

18. |||||..... 53%  Asadollahi K, Beeching NJ, Gill GV: Leukocytosis as a predictor for non-infective mortality and morbidity. QJM; 2010 May;103(5):285-92

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis as a predictor for non-infective mortality and morbidity.

Leukocytosis (raised concentration of white cells in the blood) is commonly associated with infection or inflammation, but can occur in a wide variety of other conditions.

Leukocytosis has also been linked with increased mortality and morbidity in a number of studies.

We have systematically reviewed the relevant literature, which clearly demonstrates an association between leukocytosis and mortality-particularly due to cardiovascular or cerebrovascular causes.

The mechanisms of this effect are uncertain but, when combined with other markers predictive of death, leukocytosis may contribute to modelling systems to predict in-patient mortality risk.

[MeSH-major] Cardiovascular Diseases / mortality. Leukocytosis / mortality

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(PMID = 20056764.001).

[ISSN] 1460-2393

[Journal-full-title] QJM : monthly journal of the Association of Physicians

[ISO-abbreviation] QJM

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Number-of-references] 46

   

19. |||||..... 53%  Paul DA, Zook K, Mackley A, Locke RG: Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants. J Perinatol; 2010 Jan;30(1):58-62

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants.

OBJECTIVE: To investigate the association between leukocytosis, mortality and bronchopulmonary dysplasia (BPD) in very-low-birth-weight infants (VLBW) born to mothers with histological chorioamnionitis.

Total white blood cells (WBCs) after birth were measured.

Leukocytosis was defined as a total WBC count >30 000 per mm(3) in the first 2 days of life.

RESULT: After controlling for potential confounding variables, infants who developed a leukocytosis after birth had increased odds of BPD (4.6, 95% confidence interval (95% CI): 2.0 to 10.3), but decreased odds of death (0.3, 95% CI: 0.1 to 0.90).

CONCLUSION: In our population of VLBW infants born to mothers with histological chorioamnionitis, leukocytosis after birth is associated with a decrease in mortality but an increase in BPD.

[MeSH-major] Bronchopulmonary Dysplasia / blood. Chorioamnionitis / mortality. Infant, Very Low Birth Weight / blood. Leukocytosis / complications

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(PMID = 19710675.001).

[ISSN] 1476-5543

[Journal-full-title] Journal of perinatology : official journal of the California Perinatal Association

[ISO-abbreviation] J Perinatol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

20. |||||..... 53%  [Iron metabolism regulatory mechanisms in initial leukocytosis in patients with acute leukemia]. Ter Arkh; 2011;83(10):22-7

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Iron metabolism regulatory mechanisms in initial leukocytosis in patients with acute leukemia].

AIM: To study levels of hepsidine (Hp), hypoxia-inducible factor-1alpha (HIF-1alpha), erythropoietin (EP) and ferritin in patients with acute leukemia (AL), effects of protein fractions of homogenate of blastic cells (BC) on regulatory proteins studied.

MATERIAL AND METHODS: Depending on leukocyte count in the onset of AL, 70 patients with first ever diagnosed AL were divided into two groups: group 1 - 17 patients with leukocyte count > 30 x 10(9)/l, group 2 - 53 patients with leukocyte count < 30 x 10(9)/l.

Serum and leukocyte parameters were studied before treatment, during the treatment with cytostatic drugs, in the course of myelotoxic agranulocytosis (MTA), after normalization of hemograms.

EP was detected with enzyme immunoassay, serum and leukocyte ferritin - with radioimmunoassay; HIF-1alpha, Hp - sandwich enzyme immunoassay using monospecific antisera and monoclonal antibodies against relevant antigens.

Leukocytes were isolated in ficol and verografin solutions density gradient.

Chromatographic division of the protein fractions in 3 patients with leukocytosis in AL onset and leukocytes of 3 donors was made by the method of preparative isoelectrofocusing of BC and leukocytes on LKB colon (Sweden).

RESULTS: Leukocytosis patients with initial AL have serum ferritin, Hp and HIF-1alpha levels about 2-5 times lower than patients without leukocytosis.

It is detected that protein fractions isolated from leukocytes of patients with leukocytosis in the disease onset raise HIF-1alpha content irrespective of HIF-1alpha presence in the fraction.

CONCLUSION: Great difficulties exist in ferritin and Hp levels between AL patients with leukocytosis in the onset of the disease and without of leukocytosis.

The study of leukocytes suggests that tumor cells of such patients contain compounds which can regulate production of HIF-1alpha, Hp and ferritin.

[MeSH-major] Iron / metabolism. Leukemia / blood. Leukocytosis / blood

[MeSH-minor] Acute Disease. Erythropoietin / blood. Erythropoietin / metabolism. Ferritins / blood. Ferritins / metabolism. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / blood. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Radioimmunoassay

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(PMID = 22185020.001).

[ISSN] 0040-3660

[Journal-full-title] Terapevticheskiĭ arkhiv

[ISO-abbreviation] Ter. Arkh.

[Language] rus

[Publication-type] English Abstract; Journal Article

[Publication-country] Russia (Federation)

[Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 11096-26-7 / Erythropoietin; 7439-89-6 / Iron; 9007-73-2 / Ferritins

   

21. |||||..... 52%  Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A: Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care; 2012;16(1):R12

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern.

INTRODUCTION: Following trauma and systemic inflammatory response syndrome (SIRS), the typical response is an elevation of the total complete blood count (CBC) and a reduction of the lymphocyte count.

This leukocytosis typically returns to normal within 48 hours.

The persistence of a leukocytosis following trauma is associated with adverse outcomes.

Although lymphocyte anergy and dysfunction following trauma is associated with increased risk for infection and sepsis, there is a paucity of data regarding the impact of a persistence of a low lymphocyte count in trauma patients.

Leukocyte, neutrophil and lymphocyte counts were extracted from the daily complete blood count (CBC).

Patients were then grouped based on response (elevation/depression) of each component of the CBC, and their return, or failure thereof, to normal.

When adjusting for age, gender and ISS the relative risk of death was elevated with a persistent leukocytosis (2.501 (95% CI=1.477-4.235)) or failure to normalize lymphopenia (1.639 (95% CI=10.17-2.643)) within the first 4 days following admission.

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[Cites] J Leukoc Biol. 2011 Mar;89(3):359-72 [21097697.001]

[Cites] Clin Chest Med. 2008 Dec;29(4):617-25, viii [18954697.001]

[Cites] J Trauma. 1993 Dec;35(6):844-9 [8263980.001]

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[Cites] Crit Care Med. 1999 Apr;27(4):733-40 [10321662.001]

[Cites] Injury. 1999 Apr;30(3):179-85 [10476263.001]

[Cites] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14541-6 [10588741.001]

[Cites] J Trauma. 2000 Oct;49(4):647-52; discussion 652-3 [11038081.001]

[Cites] Bratisl Lek Listy. 2001;102(1):5-14 [11723675.001]

[Cites] J Trauma. 2002 Aug;53(2):245-50; discussion 250-1 [12169929.001]

[Cites] J Anesth. 2002;16(2):131-7 [14517664.001]

[Cites] J Immunol. 2005 Mar 1;174(5):2957-63 [15728508.001]

[Cites] Crit Care Med. 2005 Dec;33(12):2836-40 [16352967.001]

[Cites] Shock. 2005 Dec;24 Suppl 1:33-9 [16374370.001]

[Cites] Microbes Infect. 2006 Apr;8(5):1382-9 [16679040.001]

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[Cites] J Trauma. 1995 Feb;38(2):185-93 [7869433.001]

(PMID = 22264310.001).

[ISSN] 1466-609X

[Journal-full-title] Critical care (London, England)

[ISO-abbreviation] Crit Care

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC3396248

   

22. |||||..... 52%  Petterino C, Luzio E, Baracchini L, Ferrari A, Ratto A: Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol; 2011 Mar;40(1):89-94

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Paraneoplastic leukocytosis in a dog with a renal carcinoma.

Nonregenerative anemia, mild leukocytosis, marked hypoalbuminemia, and hematuria were observed.

Cytologic examination of fine-needle aspirates and imprints of the right kidney revealed a neoplastic cell population suggestive of renal carcinoma.

The histopathologic diagnosis was chromophobic cystic-papillary renal carcinoma.

The tumor cells expressed granulocytic/macrophage-colony-stimulating factor (GM-CSF), detected by immunohistochemical staining, and elaboration of GM-CSF by the tumor may have mediated the leukocytosis in this dog.

Following excision of the tumor, neutrophil and monocyte counts were only mildly increased.

The dog died 135 days after initial presentation, and a necropsy was not permitted.

Paraneoplastic neutrophilic leukocytosis is an uncommon finding and may be caused by elaboration of CSF by neoplastic cells.

[MeSH-major] Carcinoma, Renal Cell / veterinary. Dog Diseases / pathology. Kidney Neoplasms / veterinary. Leukocytosis / veterinary. Paraneoplastic Syndromes / veterinary

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[Copyright] ©2011 American Society for Veterinary Clinical Pathology.

[CommentIn] Vet Clin Pathol. 2011 Jun;40(2):137; author reply 137 [21631565.001]

(PMID = 21291490.001).

[ISSN] 1939-165X

[Journal-full-title] Veterinary clinical pathology / American Society for Veterinary Clinical Pathology

[ISO-abbreviation] Vet Clin Pathol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor

   

23. |||||..... 52%  Tompkins C, Cheng A, Brinker JA, Marine JE, Nazarian S, Spragg DD, Sinha S, Halperin H, Tomaselli GF, Berger RD, Calkins H, Henrikson CA: Significance of leukocytosis after cardiac device implantation. Am J Cardiol; 2013 Jun 1;111(11):1608-12

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Significance of leukocytosis after cardiac device implantation.

Whether early postprocedural leukocytosis, a recognized marker of infection, is an indicator of impending infection is unclear and was the focus of this study.

The association between change in white blood cell (WBC) count and development of infection after device implantation was assessed.

Pre- and postprocedural WBC counts were obtained within 48 hours of the procedure.

Significant leukocytosis was defined as a ≥50% increase in WBC count; 1,245 device implantations met inclusion criteria.

A modest 17.6 ± 30.2% increase in WBC count was observed for the entire cohort.

Cases resulting in infection demonstrated minimal change in WBC count (mean +5.5 ± 26.5%).

No infections occurred in patients with ≥50% increases in WBC count or postprocedural WBC counts >15,000/μl.

Subjects with significant leukocytosis were younger (mean age 61.9 ± 16.5 vs 65.6 ± 15.1 years, p <0.01), had longer procedure times (mean 198 ± 97 vs 170 ± 77 minutes, p <0.001), and received biventricular implantable cardioverter-defibrillators (25% vs 13.9%, p <0.001).

In conclusion, after device implantation, a ≥50% increase in WBC count occurred in about 10% to 15% of patients.

Age, race, type of device, and procedure time influenced the development of significant leukocytosis.

Elevation in WBC count after cardiac device implantation was not associated with an increased risk for early infection.

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[Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.

(PMID = 23523060.001).

[ISSN] 1879-1913

[Journal-full-title] The American journal of cardiology

[ISO-abbreviation] Am. J. Cardiol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

24. |||||..... 52%  Carobbio A, Antonioli E, Guglielmelli P, Vannucchi AM, Delaini F, Guerini V, Finazzi G, Rambaldi A, Barbui T: Leukocytosis and risk stratification assessment in essential thrombocythemia. J Clin Oncol; 2008 Jun 1;26(16):2732-6

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis and risk stratification assessment in essential thrombocythemia.

PURPOSE: Established risk factors for thrombosis in essential thrombocythemia (ET) include age and previous vascular events.

We aimed to refine this risk stratification by adding baseline leukocytosis.

PATIENTS AND METHODS: We enrolled 657 patients with ET followed for a median of 4.5 years who developed 72 major thrombosis.

Cox proportional hazard model was performed to analyze the thrombotic risk and to discriminate ET patients with or without thrombosis, multivariable C statistic index was used.

We searched for leukocytes cutoff with the best sensitivity and specificity by a receiver operating characteristic curve.

RESULTS: Results confirmed that age and prior events are independent risk factors for thrombosis and showed a gradient between baseline leukocytosis and thrombosis.

On the contrary, no significant association was found either for JAK2(V617F) allele burden and for other laboratory parameters, including platelet number.

In the model with conventional risk factors alone, C statistic ratio for total thrombosis was 0.63 and when leukocytosis was added, the change was small (C = 0.67).

In contrast, in younger and asymptomatic patients (low-risk category), C statistic value indicated an high risk for thrombosis in patients with leukocytosis, similar to that calculated in conventionally defined high-risk group (C = 0.65).

The best leukocyte cutoff values for predicting the events was found to be 9.4 (x 10(9)/L).

CONCLUSION: We suggest to include baseline leukocytosis in the risk stratification of ET patients enrolled in clinical trials.

[MeSH-major] Janus Kinase 2 / genetics. Leukocytosis / complications. Thrombocythemia, Essential / complications. Thrombosis / etiology

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Aging / blood. Child. Female. Genotype. Humans. Male. Middle Aged. Polycythemia Vera / physiopathology. Prognosis. Proportional Hazards Models. Risk Factors

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(PMID = 18443353.001).

[ISSN] 1527-7755

[Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology

[ISO-abbreviation] J. Clin. Oncol.

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] EC 2.7.10.2 / Janus Kinase 2

   

25. |||||..... 52%  Cooper ES, Berry MP, McMurray RG, Hosick PA, Hackney AC: Core temperature influences on the relationship between exercise-induced leukocytosis and cortisol or TNF-alpha. Aviat Space Environ Med; 2010 May;81(5):460-6

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Core temperature influences on the relationship between exercise-induced leukocytosis and cortisol or TNF-alpha.

INTRODUCTION: The extent to which exercise in the heat modifies leukocytosis and the relationship between the leukocytosis and tumor necrosis factor-alpha (TNF-alpha) or cortisol is not well understood.

Thus, this study attempted to determine the combined effect of exercise and differing elevations in core temperature on exercise-induced leukocytosis and to examine associations between any leukocytosis and cortisol orTNF-alpha.

Leukocytes, TNF-alpha, and cortisol were determined at baseline, immediately post-, and 2 h post-exercise.

RESULTS: Both trials resulted in significant 13-33% increases in total leukocytes, mostly driven by a 24-30% increase in neutrophils.

A significant relationship was found between the change in core temperature (T(re)) during exercise and the increase in total leukocytes (r = 0.561).

Yet the exercise-induced change in cortisol was not significantly correlated to any changes in leukocytes.

There was a trend for the relationships between the exercise-induced change in TNF-alpha and the changes in total leukocytes (r = 0.491) and neutrophils (r = 0.479).

DISCUSSION: These results suggest that although neither cortisol nor TNF-alpha are strong predictors of the leukocyte response during exercise or recovery, each factor may be one of many potential modifiers of the total leukocyte response.

[MeSH-major] Body Temperature / physiology. Exercise / physiology. Hot Temperature. Hydrocortisone / blood. Leukocytosis. Tumor Necrosis Factor-alpha / blood

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(PMID = 20464812.001).

[ISSN] 0095-6562

[Journal-full-title] Aviation, space, and environmental medicine

[ISO-abbreviation] Aviat Space Environ Med

[Language] eng

[Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; 50-23-7 / Hydrocortisone

   

26. |||||..... 52%  Qiu MZ, Xu RH, Ruan DY, Li ZH, Luo HY, Teng KY, Wang ZQ, Li YH, Jiang WQ: Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China. Tumour Biol; 2010 Dec;31(6):633-41

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China.

We identified all patients in Cancer Center of Sun Yat-sen University who were diagnosed as solid tumors (breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma, esophageal carcinoma, gastric cancer, cervical carcinoma, endometrial cancer, renal cell carcinoma, and non-small cell lung cancer) between January 2000 and August 2009.

All subjects were investigated regarding levels of white blood cells, platelets, and hemoglobin concentration.

The percentages of leukocytosis, anemia, and thrombocytosis in patients with solid tumors ranged from 4.0% to 25.6%, 3.3% to 29.2%, and 2.1% to 9.7%, respectively.

Leukocytosis was an independent prognostic factor in patients with cervical cancer (P = 0.007).

A pretreatment anemia or leukocytosis can serve as a useful marker to predict outcome of patients in some of the solid tumors.

[MeSH-major] Anemia / epidemiology. Breast Neoplasms / complications. Esophageal Neoplasms / complications. Leukocytosis / epidemiology. Liver Neoplasms / complications. Stomach Neoplasms / complications. Thrombocytosis / epidemiology

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(PMID = 20652781.001).

[ISSN] 1423-0380

[Journal-full-title] Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

[ISO-abbreviation] Tumour Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Netherlands

   

27. |||||..... 51%  Jia J, Ren J, Gu J, Di L, Song G: Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis. Rare Tumors; 2010;2(3):e44

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis.

Sarcomatoid carcinoma is an extremely rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells.

Limited data on sarcomatoid carcinoma showed that most cases occurred with advanced local disease and metastasis, and paraneoplastic syndromes were rare.

We present the case of a 63-year-old man with lung sarcomatoid carcinoma associated with jejunum metastasis and leukocytosis, and its clinical, macroscopic, and histopathological features.

This case emphasizes the importance of recognizing paraneoplastic syndromes and metastasis of sarcomatoid carcinoma at diagnosis.

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(PMID = 21139960.001).

[ISSN] 2036-3613

[Journal-full-title] Rare tumors

[ISO-abbreviation] Rare Tumors

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

[Other-IDs] NLM/ PMC2994519

   

28. |||||..... 51%  Barbui T, Carobbio A, Rambaldi A, Finazzi G: Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor? Blood; 2009 Jul 23;114(4):759-63

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor?

Leukocyte (WBC) count has been recently identified as an independent predictor of major thrombosis in both essential thrombocythemia (ET) and polycythemia vera (PV).

However, whether leukocytosis should be simply considered a marker for vascular disease or whether elevated WBC levels actually contribute directly to causing such disorders is presently matter of many studies.

Our conclusion supports the notion that baseline leukocytosis in ET and PV patients adds prognostic significance to existing risk factors and that may be considered causative of vascular events.

These developments could induce clinicians to incorporate WBC count into standard clinical practice.

However, we need prospective clinical studies with stratification of patients according to their baseline leukocyte counts.

[MeSH-major] Leukocytosis / complications. Polycythemia Vera / complications. Thrombocythemia, Essential / complications. Thrombosis / etiology

[MeSH-minor] Aged. Aged, 80 and over. Cohort Studies. Disease Susceptibility. Follow-Up Studies. Humans. Leukocyte Count. Middle Aged. Platelet Count. Risk Factors. Sensitivity and Specificity

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[Cites] Mayo Clin Proc. 2006 Feb;81(2):159-66 [16471068.001]

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(PMID = 19372254.001).

[ISSN] 1528-0020

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Other-IDs] NLM/ PMC2716019

   

29. |||||..... 50%  Chou YS, Gau JP, Yu YB, Pai JT, Hsiao LT, Liu JH, Hong YC, Liu CY, Yang CF, Chen PM, Chiou TJ, Tzeng CH: Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage. Eur J Haematol; 2013 Mar;90(3):228-36

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage.

BACKGROUND: Long-term outcomes are favorable for patients with polycythemia vera (PV) and for patients with essential thrombocythemia (ET).

METHODS: We retrospectively recruited 247 patients who had received a diagnosis of PV (n = 101) or ET (n = 146) during the period 2001-2010.

RESULTS: After a median follow-up period of 36.2 months, the cumulative incidence of hemorrhage was 39.6% in patients with PV (6.2% per person-year) and 29.7% in patients with ET (5.9% person-years).

Episodes of major bleeding occurred in 9.9% of patients with PV and in 14.4% of patients with ET.

Overall survival was significantly shorter among patients with hemorrhage than among those without said complication (P < 0.001 for overall patients; P = 0.002 for patients with PV; P = 0.026 for patients with ET).

In the univariate analysis, age ≥ 60 yr (OR: 4.77, P = 0.046) and WBC ≥ 16 × 10(9) /L (OR: 4.15, P = 0.010) were predictors of hemorrhage in patients with PV, and age ≥ 60 yr (OR: 3.25, P = 0.040), WBC ≥ 16 × 10(9) /L (OR: 2.89, P = 0.024), albumin <4.0 g/dL (OR: 4.10, P = 0.002), and splenomegaly (OR: 5.19, P = 0.002) were predictors of hemorrhage in patients with ET.

Multivariate analysis showed that WBC ≥ 16 × 10(9) /L was the only significant risk factor for hemorrhage in patients with PV (OR: 3.51, P = 0.026) and that splenomegaly was the only risk factor for hemorrhage in patients with ET (OR: 3.00, P = 0.048).

CONCLUSION: Leukocytosis in PV and splenomegaly in ET are independent risk factors for hemorrhage.

[MeSH-major] Hemorrhage / complications. Leukocytosis / complications. Polycythemia Vera / complications. Splenomegaly / complications. Thrombocythemia, Essential / complications

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Leukocyte Count. Leukocytes / pathology. Male. Middle Aged. Retrospective Studies. Risk Factors. Survival Rate

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[Copyright] © 2013 John Wiley & Sons A/S.

(PMID = 23281576.001).

[ISSN] 1600-0609

[Journal-full-title] European journal of haematology

[ISO-abbreviation] Eur. J. Haematol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

   

30. |||||..... 49%  Canzoneri BJ, Lewis DF, Groome L, Wang Y: Increased neutrophil numbers account for leukocytosis in women with preeclampsia. Am J Perinatol; 2009 Nov;26(10):729-32

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Increased neutrophil numbers account for leukocytosis in women with preeclampsia.

We evaluated the leukocyte differentials in women with normal pregnancies and in pregnancies complicated by preeclampsia (PE).

Leukocyte total and neutrophil, lymphocyte, monocyte, eosinophil, basophil, hemoglobin, and platelet counts were analyzed by analysis of variance and pairwise comparison.

The total leukocyte count was significantly increased in women with severe PE compared with women with mild PE and normal pregnant controls: 10.66 +/- 3.70 ( P < 0.0001) versus 9.47 +/- 2.59 and 8.55 +/- 1.93 (1 x 10 (3)/microL), respectively.

The increased total leukocyte count was mainly due to the increase in neutrophil numbers: 8.05 +/- 4.01 (severe; P < 0.0001) versus 6.69 +/- 2.23 (mild) and 5.90 +/- 1.79 (controls), respectively.

The total neutrophil count was further increased 48 hours after delivery in the group with severe PE.

Increased neutrophil numbers account for the leukocytosis in women with PE.

[MeSH-major] Leukocytosis / blood. Leukocytosis / epidemiology. Neutrophils / metabolism. Pre-Eclampsia / blood. Pre-Eclampsia / epidemiology

[MeSH-minor] Adult. Causality. Comorbidity. Erythrocyte Count. Female. Humans. Louisiana. Lymphocyte Count. Platelet Count. Pregnancy. Reference Values. Retrospective Studies. Risk Factors. Severity of Illness Index

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[Copyright] (c) Thieme Medical Publishers.

[Cites] Br J Obstet Gynaecol. 1997 Jul;104(7):851-3 [9236656.001]

[Cites] Gynecol Obstet Invest. 1998;45(4):229-31 [9623786.001]

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(PMID = 19452432.001).

[ISSN] 1098-8785

[Journal-full-title] American journal of perinatology

[ISO-abbreviation] Am J Perinatol

[Language] eng

[Grant] United States / NICHD NIH HHS / HD / R01 HD036822-08; United States / NHLBI NIH HHS / HL / R01 HL065997-08

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Other-IDs] NLM/ NIHMS266056; NLM/ PMC3062252

   

31. |||||..... 49%  Mabuchi S, Matsumoto Y, Isohashi F, Yoshioka Y, Ohashi H, Morii E, Hamasaki T, Aozasa K, Mutch DG, Kimura T: Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer. Gynecol Oncol; 2011 Jul;122(1):25-32

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer.

OBJECTIVES: The aim of this study was to investigate the prognostic value of pretreatment leukocytosis in patients with cervical cancer in relation to well-established conventional risk factors.

Subsequently, the prognostic significance of pretreatment WBC count was prospectively investigated in 156 patients newly diagnosed cervical cancer from 2007 April to 2010 March.

RESULTS: In a retrospective analysis, patients with leukocytosis (WBC ≥ 10,000/μl) showed significantly higher treatment failure rate (P < 0.0001) and shorter OS (P < 0.0001) than the patients without leukocytosis.

Tumors from patients with leukocytosis showed significantly stronger immunoreactivity for G-CSF than those obtained from patients without leukocytosis.

Multivariate analyses revealed that clinical stage, tumor diameter, histology, and elevated WBC count (≥ 10,000/μl) were significant prognostic factors in terms of overall survival.

In a prospective investigation, patients with leukocytosis showed significantly higher treatment failure rate (P < 0.0001), shorter PFS (P < 0.0001), and higher serum G-CSF concentrations (p = 0.001) than the patients without leukocytosis.

Multivariate analyses revealed that clinical stage, tumor diameter, and elevated WBC count were significant prognostic factors in terms of PFS.

CONCLUSION: Pretreatment leukocytosis is an independent prognostic factor in patients with cervical cancer.

Our finding can be used to identify patients with poor prognosis and to design future tailored clinical trials.

[MeSH-major] Leukocytosis / pathology. Uterine Cervical Neoplasms / blood

[MeSH-minor] Adult. Aged. Female. Granulocyte Colony-Stimulating Factor / biosynthesis. Granulocyte Colony-Stimulating Factor / blood. Humans. Leukocyte Count. Middle Aged. Neoplasm Staging. Neutrophils / pathology. Prognosis. Proportional Hazards Models. Retrospective Studies. Risk Factors

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[Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.

(PMID = 21514632.001).

[ISSN] 1095-6859

[Journal-full-title] Gynecologic oncology

[ISO-abbreviation] Gynecol. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor

   

32. |||||..... 48%  Díaz-Rosales Jde D, Enríquez-Domínguez L, Castillo-Moreno JR, Herrera-Ramírez F: [Preoperative leukocytosis as a predictor of intrabdominal injury in penetrating abdominal trauma]. Cir Cir; 2012 Nov-Dec;80(6):516-22

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Preoperative leukocytosis as a predictor of intrabdominal injury in penetrating abdominal trauma].

[Transliterated title] Leucocitosis prequirúrgica como factor predictivo de lesión a órgano intrabdominal en trauma penetrante abdominal.

Is possible use some grade of leukocytosis suspect in-trabdominal lesion?

Dependent variables were; age, gender, type of injury, number of lesions, peripheral lesions, time between injury and, from a laboaratory blood sample, leukocytosis mean, percentage of neutrophils, leukocytosis ≥ 12,500 /mm(3), and hemoperitoneum.

Leukocytosis global was 13.2 mil/mm(3) and neutrophil range of 70.3%.

26% of patients did not have leukocytosis at arrival and evaluation, however they were laparotomized because of present peritoneal irritation.

Leukocytosis ≥ 12.5 mil/mm(3) was statistically significant in patients with intrabdominal lesions (74.2% vs 27.7%, p < 0.001).

CONCLUSIONS: leukocytosis ≥ 12.5 mil/mm(3) could be an early serum marker abdominal penetrating trauma.

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(PMID = 23336145.001).

[ISSN] 0009-7411

[Journal-full-title] Cirugia y cirujanos

[ISO-abbreviation] Cir Cir

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Mexico

   

33. |||||..... 48%  Hurtado-Cordovi J, Pathak P, Avezbakiyev B, Frieri M: Inflammatory malignant fibrous histiocytoma associated with leukemoid reaction or leukocytosis: a comprehensive review. ISRN Oncol; 2012;2012:946019

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Inflammatory malignant fibrous histiocytoma associated with leukemoid reaction or leukocytosis: a comprehensive review.

Inflammatory malignant fibrous histiocytoma (IMFH) associated with leukemoid reaction (LR)/leukocytosis is a rare entity.

In this paper, we search PubMed for all known cases of IMFH associated with LR/leukocytosis in an attempt to draw conclusions about this variant's response to treatments and its pathophysiology.

Medline electronic database was searched using key words such as malignant fibrous histiocytoma, leukemoid reaction, and leukocytosis.

Of the 12 patients that expired, death occurred approximately 92 days after the onset of LR or leukocytosis, ranging from 3 to 334 days.

We conclude that IMFH associated with LR/leukocytosis does not completely respond to chemoradiation.

Overproduction of growth factors and cytokines by IMFH cells and their interactions with the inflammatory infiltrate seem to promote immunological effector cell's dysfunction and substantiate the development and growth of this neoplasm.

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(PMID = 23097722.001).

[ISSN] 2090-567X

[Journal-full-title] ISRN oncology

[ISO-abbreviation] ISRN Oncol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Egypt

[Other-IDs] NLM/ PMC3477745

   

34. |||||..... 47%  Deirmengian GK, Zmistowski B, Jacovides C, O'Neil J, Parvizi J: Leukocytosis is common after total hip and knee arthroplasty. Clin Orthop Relat Res; 2011 Nov;469(11):3031-6

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis is common after total hip and knee arthroplasty.

Although leukocytosis may be a sign of a developing infection in the early postoperative period, it may also be part of a normal surgical response.

QUESTIONS AND PURPOSES: We determined (1) the natural history of white blood cell values after primary THA and TKA, (2) factors associated with early postoperative leukocytosis, and (3) the predictive value of white blood cell count for early postoperative periprosthetic joint infection.

We determined the incidence of leukocytosis and characterized the natural history of postoperative white blood cell counts.

We then investigated potential indicators of postoperative leukocytosis, including development of early periprosthetic infection.

RESULTS: The average postoperative white blood cell count increased to approximately 3 × 10(6) cells/μL over the first 2 postoperative days and then declined to a level slightly higher than the preoperative level by Postoperative Day 4.

The incidence of postoperative leukocytosis for all patients was 38%.

Factors associated with postoperative leukocytosis included TKA, bilateral procedures, older age, and higher modified Charlson Comorbidity Index.

The sensitivity and specificity of white blood cell count for diagnosing early periprosthetic infection were 79% and 46%, respectively.

CONCLUSIONS: Postoperative leukocytosis is common after THA and TKA and represents a normal physiologic response to surgery.

In the absence of abnormal clinical signs and symptoms, postoperative leukocytosis may not warrant further workup for infection.

[MeSH-major] Arthroplasty, Replacement, Hip / adverse effects. Arthroplasty, Replacement, Knee / adverse effects. Leukocytosis / diagnosis. Prosthesis-Related Infections / diagnosis

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Comorbidity. Databases, Factual. Female. Humans. Leukocyte Count. Male. Middle Aged. Pennsylvania / epidemiology. Postoperative Complications. Predictive Value of Tests. Young Adult

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[Cites] J Clin Epidemiol. 1992 Jun;45(6):613-9 [1607900.001]

[Cites] J Bone Joint Surg Am. 1996 Apr;78(4):512-23 [8609130.001]

[Cites] J Bone Joint Surg Am. 1999 May;81(5):672-83 [10360695.001]

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(PMID = 21461866.001).

[ISSN] 1528-1132

[Journal-full-title] Clinical orthopaedics and related research

[ISO-abbreviation] Clin. Orthop. Relat. Res.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3183208

   

35. |||||..... 47%  Chronic leukocytosis. Blood; 2008 Apr 1;111(7):3908

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Chronic leukocytosis.

[MeSH-major] Leukocytosis / pathology

[MeSH-minor] Chronic Disease. Diagnosis, Differential. False Positive Reactions. Hemoglobins / analysis. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive. Leukocyte Count. Male. Middle Aged

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(PMID = 18362215.001).

[ISSN] 0006-4971

[Journal-full-title] Blood

[ISO-abbreviation] Blood

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Hemoglobins

   

36. |||||..... 46%  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T: Ultrasonography for leukocytosis or elevated C-reactive protein. Hepatogastroenterology; 2011 Jul-Aug;58(109):1156-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Ultrasonography for leukocytosis or elevated C-reactive protein.

BACKGROUND/AIMS: Patients with abdominal symptoms and leukocytosis or elevated C-reactive protein were subjected to abdominal ultrasonography (US) for correct diagnosis.

METHODOLOGY: Patients with abdominal symptoms, leukocytosis and elevated C-reactive protein were enrolled.

Those with abnormal liver enzymes or radiographs were excluded since either of them might be a clue to proper diagnosis, such as hepatobiliary diseases or bowel obstruction.

RESULTS: Total number of patients was 38.

Number of acute diverticulitis, colitis, acute appendicitis and enteritis were 8, 7, 7 and 6, respectively.

Colon cancers were confirmed and pelvis tumor was diagnosed as ovarian squamous cell carcinoma with surgical specimens.

CONCLUSIONS: Our data clearly recommended that abdominal US be performed carefully for patients with abdominal symptoms and leukocytosis or elevated CRP since potentially they had malignancies.

[MeSH-major] Abdomen / ultrasonography. C-Reactive Protein / analysis. Leukocytosis / ultrasonography

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(PMID = 21937369.001).

[ISSN] 0172-6390

[Journal-full-title] Hepato-gastroenterology

[ISO-abbreviation] Hepatogastroenterology

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

[Chemical-registry-number] 9007-41-4 / C-Reactive Protein

   

37. |||||..... 45%  Gangat N, Wolanskyj AP, Schwager SM, Hanson CA, Tefferi A: Leukocytosis at diagnosis and the risk of subsequent thrombosis in patients with low-risk essential thrombocythemia and polycythemia vera. Cancer; 2009 Dec 15;115(24):5740-5

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis at diagnosis and the risk of subsequent thrombosis in patients with low-risk essential thrombocythemia and polycythemia vera.

BACKGROUND: Advanced age and a history of thrombosis were well-established risk factors for thrombosis in essential thrombocythemia (ET) and polycythemia vera (PV); cytoreductive therapy was indicated in their presence.

Recent studies have suggested leukocytosis as an additional risk factor; however, such an association would be treatment-relevant in the context of low-risk disease.

METHODS: In this retrospective study, a Cox proportional hazards model was used to determine the impact of various clinical and laboratory variables, including leukocytosis, on thrombosis-free survival (TFS).

Arterial-specific or venous-specific TFS curves for different leukocyte count-defined risk groups were constructed by the Kaplan-Meier method and compared using the log-rank test.

RESULTS: A total of 407 low-risk patients (254 with ET and 153 with PV) were considered.

After a respective median follow-up of 104 months and 130 months, respectively, 47 (19%) patients with ET and 41 (27%) with PV experienced a total of 55 (41 arterial and 14 venous) and 46 (22 arterial and 24 venous) thrombotic events, respectively.

Leukocytosis at the time of diagnosis, defined by a cutoff level of either 15 or 9.4x10(9)/L, did not appear to be predictive of either arterial or venous thrombosis during follow-up; similar results were obtained when analysis was restricted to patients with platelet counts of <1000x10(9)/L.

Instead, advanced age was found to be significantly associated with arterial thrombosis in patients with PV and higher hemoglobin level with venous thrombosis in patients with ET.

CONCLUSIONS: In the current retrospective study, leukocytosis at diagnosis did not appear to influence the risk of thrombosis in either ET or PV.

However, a prospective study is required before leukocytosis is taken into account during treatment decisions in these disorders.

[MeSH-major] Leukocytosis / complications. Polycythemia Vera / complications. Thrombocythemia, Essential / complications. Thrombosis / complications

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[Copyright] Copyright (c) 2009 American Cancer Society.

(PMID = 19806641.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

38. ||||...... 45%  Deibener-Kaminsky J, Lesesve JF, Grosset S, Pruna L, Schmall-Laurain MC, Benetos A, Kaminsky P: [Clinical relevance of leukocyte differential in patients with marked leukocytosis in the emergency room]. Rev Med Interne; 2011 Jul;32(7):406-10

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Clinical relevance of leukocyte differential in patients with marked leukocytosis in the emergency room].

[Transliterated title] Signification d'une hyperleucocytose marquée et de la formule sanguine dans les situations d'urgence.

PURPOSE: We analyzed the characteristics of the leukocyte differential and the clinical outcome in patients admitted in an emergency department with marked leukocytosis greater than 20×10(9)G/L.

Admission in intensive care unit (ICU), consciousness impairment or death defined the subgroup S of high severity.

Leukocyte and neutrophil counts were significantly higher and basophil count significantly lower in subgroup S.

CONCLUSION: Marked leukocytosis indicated severe illness.

[MeSH-major] Emergency Service, Hospital. Leukocytosis / mortality

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[Copyright] Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

(PMID = 21292359.001).

[ISSN] 1768-3122

[Journal-full-title] La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne

[ISO-abbreviation] Rev Med Interne

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] France

   

39. ||||...... 45%  Paladino L, Subramanian RA, Bonilla E, Sinert RH: Leukocytosis as prognostic indicator of major injury. West J Emerg Med; 2010 Dec;11(5):450-5

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis as prognostic indicator of major injury.

OBJECTIVE: To test the diagnostic use of the triage white blood cell (WBC) count in differentiating major from minor injuries.

We recorded age, sex, injury mechanism, vital signs, WBC, base deficit (BD), lactate (LAC) and calculated injury severity scores (ISS).

Major injury was defined as either a change in hematocrit >10 points or blood transfused within 24 hours, or ISS >15.

For vital signs, blood pressure was not significantly different between major and minor injury patients.

Major compared to minor injury patients had a statistically but not clinically significant higher heart rate.

Major injury patients had significantly (p < 0.0001) higher WBC count (10.53 K/μl, 95% CI: 9.7-11.3) compared to patients with minor injuries (8.92 K/μl, 95% CI: 8.7-9.2), but both were in the normal range.

Areas under the curve for WBC count (0.60, 95% CI: 0.54-0.66) are similar to BD (0.69, 95% CI: 0.63-0.74) and LAC (0.66, 95% CI: 0.60-0.71).

CONCLUSION: WBC count is not a useful addition as a diagnostic indicator of major trauma in our study population.

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(PMID = 21293764.001).

[ISSN] 1936-9018

[Journal-full-title] The western journal of emergency medicine

[ISO-abbreviation] West J Emerg Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3027437

   

40. ||||...... 45%  De Stefano V, Za T, Rossi E, Vannucchi AM, Ruggeri M, Elli E, Micò C, Tieghi A, Cacciola RR, Santoro C, Gerli G, Guglielmelli P, Pieri L, Scognamiglio F, Rodeghiero F, Pogliani EM, Finazzi G, Gugliotta L, Leone G, Barbui T, GIMEMA Chronic Myeloproliferative Neoplasms Working Party: Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia. Am J Hematol; 2010 Feb;85(2):97-100

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis is a risk factor for recurrent arterial thrombosis in young patients with polycythemia vera and essential thrombocythemia.

There is evidence that leukocytosis is associated with an increased risk of first thrombosis in patients with polycythemia vera (PV) and essential thrombocythemia (ET).

In the frame of a multicenter retrospective cohort study, we recruited 253 patients with PV (n = 133) or ET (n = 120), who were selected on the basis of a first arterial (70%) or venous major thrombosis (27.6%) or both (2.4%), and who were not receiving cytoreduction at the time of thrombosis.

The probability of recurrent thrombosis associated with the leukocyte count recorded at the time of the first thrombosis was estimated by a receiver operating characteristic analysis and a multivariable Cox proportional hazards regression model.

Thrombosis recurred in 78 patients (30.7%); multivariable analysis showed an independent risk of arterial recurrence (hazard ratio [HR] 2.16, 95% CI 1.12-4.18) in patients with a leukocyte count that was >12.4 x 10(9)/L at the time of the first thrombotic episode.

The prognostic role for leukocytosis was age-related, as it was only significant in patients that were aged <60 years (HR for arterial recurrence 3.35, 95% CI 1.22-9.19).

[MeSH-major] Leukocytosis / epidemiology. Polycythemia Vera / epidemiology. Thrombocythemia, Essential / epidemiology. Thrombosis / epidemiology

[MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Female. Humans. Leukocyte Count. Male. Middle Aged. Retrospective Studies. Risk Factors

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(PMID = 20052743.001).

[ISSN] 1096-8652

[Journal-full-title] American journal of hematology

[ISO-abbreviation] Am. J. Hematol.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] United States

[Investigator] Barbui T; De Stefano V; De Stefano V; Rossi E; Za T; Fiorini A; Leone G; Vannucchi AM; Guglielmelli P; Pieri L; Bosi A; Ruggeri M; Scognamiglio F; Rodeghiero F; Elli E; Pogliani EM; Micó C; Finazzi G; Barbui T; Tieghi A; Gugliotta L; Cacciola RR; Cacciola E; Giustolisi R; Santoro C; Mazzucconi MG; Gerli G; Caberlon S; Fontana G; Cattaneo M; Seràgnoli L; Seràgnoli A; Lucchesi A; Vianelli N

   

41. ||||...... 44%  Sun W, Peacock A, Becker J, Phillips-Bute B, Laskowitz DT, James ML: Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. J Clin Neurosci; 2012 Aug;19(8):1096-100

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a devastating and common admitting diagnosis to intensive care units in the USA.

Using the Duke University Hospital Neuroscience Critical Care Unit Database, we retrospectively identified patients with an admitting diagnosis of supratentorial ICH from January to December 2010, verified by CT imaging.

ICH score, presence of midline shift on imaging, and white blood cell (WBC) count were used in a regression model for predicting END.

WBC count demonstrated the greatest association with END.

Elevated WBC count appears predictive of deterioration.

[MeSH-major] Cerebral Hemorrhage / complications. Leukocytosis / etiology. Nervous System Diseases / etiology. Statistics as Topic

[MeSH-minor] Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Glasgow Coma Scale. Humans. Leukocyte Count. Male. Middle Aged. Tomography, X-Ray Computed

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[Copyright] Copyright © 2012 Elsevier Ltd. All rights reserved.

(PMID = 22704946.001).

[ISSN] 1532-2653

[Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

[ISO-abbreviation] J Clin Neurosci

[Language] eng

[Grant] United States / FIC NIH HHS / TW / D43-TW008308-01

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

[Publication-country] Scotland

   

42. ||||...... 44%  Bolasco G, Calogero R, Carrara M, Banchaabouchi MA, Bilbao D, Mazzoccoli G, Vinciguerra M: Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice. Aging (Albany NY); 2012 Jun;4(6):402-16

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice.

Using high throughput sequencing approaches in mIGF-1 transgenic mice, we identified new targets of the mIGF-1/SIRT1 signaling.

In addition to its potent cardioprotective properties, cardiac-restricted mIGF-1 transgene induced systemic changes such as high blood pressure, leukocytosis and an enhanced fear response, in a SIRT1-dependent manner.

[MeSH-major] Heart Failure / metabolism. Hypertension / metabolism. Insulin-Like Growth Factor I / metabolism. Leukocytosis / metabolism. Sirtuin 1 / metabolism

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(PMID = 22691943.001).

[ISSN] 1945-4589

[Journal-full-title] Aging

[ISO-abbreviation] Aging (Albany NY)

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Cardiotonic Agents; 67763-96-6 / Insulin-Like Growth Factor I; EC 3.5.1.- / Sirt1 protein, mouse; EC 3.5.1.- / Sirtuin 1

[Other-IDs] NLM/ PMC3409677

   

43. ||||...... 44%  Rutman MS, Bachur R, Harper MB: Radiographic pneumonia in young, highly febrile children with leukocytosis before and after universal conjugate pneumococcal vaccination. Pediatr Emerg Care; 2009 Jan;25(1):1-7

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Radiographic pneumonia in young, highly febrile children with leukocytosis before and after universal conjugate pneumococcal vaccination.

OBJECTIVES: Studies before the introduction of conjugate pneumococcal vaccine demonstrated a high rate of radiographic pneumonia among highly febrile young children with leukocytosis and no other identified source of infection.

METHODS: Retrospective cohort study of children younger than 5 years seen in an urban pediatric emergency department with temperature 39 degrees C or higher, white blood cell count 20,000/microL or higher, and chest radiograph performed.

CONCLUSIONS: Clinicians should continue to consider chest radiography in young highly febrile children with leukocytosis and no other identified source of infection.

[MeSH-major] Fever / etiology. Leukocytosis / etiology. Pneumococcal Vaccines. Pneumonia / epidemiology. Pneumonia / radiography. Vaccination / statistics & numerical data

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(PMID = 19116501.001).

[ISSN] 1535-1815

[Journal-full-title] Pediatric emergency care

[ISO-abbreviation] Pediatr Emerg Care

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Pneumococcal Vaccines; 0 / Vaccines, Conjugate; 0 / heptavalent pneumococcal conjugate vaccine

   

44. ||||...... 44%  Nidimusili AJ, Alraies MC, Eisa N, Alraiyes AH, Shaheen K: Leukocytosis of unknown origin: gangrenous cholecystitis. Case Rep Med; 2013;2013:418014

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis of unknown origin: gangrenous cholecystitis.

The current case is unique, since our patient denied any prior episodes of abdominal pain and the only tip off was leukocytosis.

A high index of suspicion is essential for the early diagnosis and treatment of GC.

The radiological investigations may not be conclusive.

There is a need for an early (if not urgent) surgical intervention in acute cholecystitis (whether laparoscopic or open surgery) in order to decrease the time elapsed from the start of symptoms to admission and treatment.

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(PMID = 23606852.001).

[ISSN] 1687-9627

[Journal-full-title] Case reports in medicine

[ISO-abbreviation] Case Rep Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC3628491

   

45. ||||...... 44%  Morag I, Dunn M, Nayot D, Shah PS: Leukocytosis in very low birth weight neonates: associated clinical factors and neonatal outcomes. J Perinatol; 2008 Oct;28(10):680-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Leukocytosis in very low birth weight neonates: associated clinical factors and neonatal outcomes.

OBJECTIVE: Primary objective was to identify clinical factors and outcomes associated with leukocytosis in very low birth weight (VLBW) neonates.

Secondary objective was to compare outcomes between infants with early-onset (<or=72 h of age) and late-onset leukocytosis (>72 h).

STUDY DESIGN: A retrospective matched cohort study of VLBW neonates born at <or=30 weeks of gestation identified with a white blood cell count of >or=40,000 was undertaken.

Matched infants had no leukocytosis and were of similar gestational age.

RESULT: Leukocytosis was identified in 96 infants giving an incidence rate of 6.1%.

Of all, 94 matched infants without leukocytosis were identified.

The incidence of confirmed infection among infants with leukocytosis was 22%.

Late-onset leukocytosis (>or=72 h of age) was associated with sepsis and necrotizing enterocolitis.

No differences in any of the other outcomes between early-onset and late-onset leukocytosis were identified.

CONCLUSION: Leukocytosis, especially late onset, was associated with infection in VLBW infants.

Late-onset leukocytosis was also associated with necrotizing enterocolitis indicating that postnatal age at time of leukocytosis should be considered when formulating clinical decisions.

[MeSH-major] Infant, Premature, Diseases / epidemiology. Leukocytosis / epidemiology

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(PMID = 18563164.001).

[ISSN] 1476-5543

[Journal-full-title] Journal of perinatology : official journal of the California Perinatal Association

[ISO-abbreviation] J Perinatol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

46. ||||...... 44%  Caramazza D, Caracciolo C, Barone R, Malato A, Saccullo G, Cigna V, Berretta S, Schinocca L, Quintini G, Abbadessa V, Di Raimondo F, Siragusa S: Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms. Ann Hematol; 2009 Oct;88(10):967-71

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.

The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive.

To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed the clinical course of 187 patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) followed at two Italian Institutions over a period of 7 years.

The association was measured at diagnosis or before thrombotic events: a multivariable analysis was carried out using data at baseline and time-dependent covariates.

We found that white blood cells (WBC) count above 9.5 x 10(9)/L at diagnosis (baseline analysis) was associated with thrombosis during the follow-up (Hazard Ratio [HR] of 1.8, p 0.03).

At the time-dependent analysis, therapy with hydroxyurea (HU), lowering by 35% the baseline WBC level, reduced such strength of association giving a HR of 1.3 (p value non significant).

We found a trend between WBC level and thrombosis in untreated low-risk patients (RR of 1.9, 95% CI 0.9 to 3.1); in high-risk patients treated with HU this correlation was clearly lost (RR 1.1, 95% CI 0.2 to 2.7).

Finally, we could not identify the presence of JAK2 (V617F) as a risk factor for thrombosis.

[MeSH-major] Leukocytosis / complications. Polycythemia Vera / complications. Thrombocythemia, Essential / complications. Thrombosis / etiology

[MeSH-minor] Aged. Female. Humans. Hydroxyurea / pharmacology. Hydroxyurea / therapeutic use. Janus Kinase 2 / genetics. Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / complications. Leukocyte Count. Male. Middle Aged. Multivariate Analysis

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(PMID = 19214510.001).

[ISSN] 1432-0584

[Journal-full-title] Annals of hematology

[ISO-abbreviation] Ann. Hematol.

[Language] eng

[Publication-type] Journal Article; Multicenter Study

[Publication-country] Germany

[Chemical-registry-number] 127-07-1 / Hydroxyurea; EC 2.7.10.2 / JAK2 protein, human; EC 2.7.10.2 / Janus Kinase 2

   

47. ||||...... 44%  Pilger D, Heukelbach J, Diederichs A, Schlosser B, Pereira Leite Costa Araújo C, Keysers A, Liesenfeld O, Feldmeier H: Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection. J Infect Dev Ctries; 2011 Apr;5(4):260-9

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Anemia, leukocytosis and eosinophilia in a resource-poor population with helmintho-ectoparasitic coinfection.

Stool and blood samples were collected and individuals were clinically examined for the presence of ectoparasites.

Leukocytosis was found in 13%, eosinophilia in 74%, and hypereosinophilia in 44% of the participants.

Our study confirms in a population with high prevalence of intestinal helminthiases and ectoparasites that eosinophilia can be used to accurately diagnose current parasitic infection and initiate treatment.

[MeSH-major] Anemia / epidemiology. Ectoparasitic Infestations / complications. Ectoparasitic Infestations / epidemiology. Eosinophilia / epidemiology. Helminthiasis / complications. Helminthiasis / epidemiology. Leukocytosis / epidemiology

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(PMID = 21537067.001).

[ISSN] 1972-2680

[Journal-full-title] Journal of infection in developing countries

[ISO-abbreviation] J Infect Dev Ctries

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Italy

   

48. ||||...... 43%  Czaplicki AP, Borger JE, Politi JR, Chambers BT, Taylor BC: Evaluation of postoperative fever and leukocytosis in patients after total hip and knee arthroplasty. J Arthroplasty; 2011 Dec;26(8):1387-9

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Evaluation of postoperative fever and leukocytosis in patients after total hip and knee arthroplasty.

Fever and leukocytosis are common after joint arthroplasty, often resulting in additional studies.

This study was conducted to determine the incidence of fever and leukocytosis after joint arthroplasty and the use of tests.

We retrospectively reviewed records (n = 426) of patients who underwent knee or hip arthroplasty between February 2006 and April 2008 to determine the incidence of fever and leukocytosis, tests, and results.

Sixty-four had fever, and 247 had postoperative leukocytosis.

After joint arthroplasty, more than half of patients developed leukocytosis, and nearly 15% developed fever.

Diagnostic testing should be based on physical examination or symptomatic findings and not solely on laboratory values or vital signs, decreasing the patient discomfort and potentially lower costs.

[MeSH-major] Arthroplasty, Replacement, Hip / adverse effects. Arthroplasty, Replacement, Knee / adverse effects. Fever / epidemiology. Fever / etiology. Leukocytosis / epidemiology. Leukocytosis / etiology

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnostic Tests, Routine. Female. Hip Prosthesis / adverse effects. Humans. Incidence. Knee Prosthesis / adverse effects. Male. Middle Aged. Postoperative Period. Prosthesis-Related Infections / diagnosis. Prosthesis-Related Infections / etiology. Retrospective Studies. Surgical Wound Infection / diagnosis. Surgical Wound Infection / etiology. Young Adult

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[Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.

[CommentIn] Z Orthop Unfall. 2011 Jun;149(3):253 [21688219.001]

(PMID = 21353453.001).

[ISSN] 1532-8406

[Journal-full-title] The Journal of arthroplasty

[ISO-abbreviation] J Arthroplasty

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

49. ||||...... 41%  Granger JM, Kontoyiannis DP: Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study. Cancer; 2009 Sep 1;115(17):3919-23

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Etiology and outcome of extreme leukocytosis in 758 nonhematologic cancer patients: a retrospective, single-institution study.

BACKGROUND: To the authors' knowledge, the literature regarding extreme leukocytosis in solid tumor patients is sparse, consisting of a few case reports and small case series.

METHODS: A total of 3770 consecutive solid tumor patients with a white blood cell count>40,000/microL were retrospectively identified over a 3-year period (2005-2008).

Those patients without a secondary cause of their leukocytosis were defined as having a paraneoplastic leukemoid reaction.

RESULTS: A total of 758 (20%) patients with solid tumors and extreme leukocytosis were identified.

The etiology of the leukocytosis was hematopoietic growth factors in 522 (69%) patients, infection in 112 (15%) patients, high-dose corticosteroids in 38 (5%) patients, newly diagnosed leukemia in 9 (1%) patients, and paraneoplastic leukemoid reaction in 77 (10%) patients.

The patients diagnosed with a paraneoplastic leukemoid reaction typically had neutrophil predominance (96%) and radiographic evidence of metastatic disease (78%), were clinically stable, and had a poor prognosis; 78% either died or were discharged to hospice within 12 weeks of their initial extreme leukocyte count.

CONCLUSIONS: Infection was an uncommon cause of extreme leukocytosis in patients with solid tumors.

[MeSH-major] Leukemoid Reaction / diagnosis. Leukocytosis / etiology

[MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Infection / complications. Leukocyte Count. Male. Middle Aged. Neoplasms / complications. Prognosis. Retrospective Studies

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(PMID = 19551882.001).

[ISSN] 0008-543X

[Journal-full-title] Cancer

[ISO-abbreviation] Cancer

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

50. ||||...... 41%  Burzyantseva O, Dharmasena S, Jayawardena S, Rupanagudi VA, Krishnan P: Hypercalcemia-leukocytosis syndrome in a patient with cavitating squamous cell carcinoma of the lung. Cases J; 2009;2(1):108

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Hypercalcemia-leukocytosis syndrome in a patient with cavitating squamous cell carcinoma of the lung.

Hypercalcemia and leukocytosis are two common paraneoplastic syndromes associated with lung cancer.

Unfortunately patients presenting with Hypercalcemia- leukocytosis syndrome has a worse prognosis than patients presenting with lung cancer alone.

CASE PRESENTATION: We present a 67 yr old Caucasian male with a history of active smoking presenting as pneumonia being diagnosed as cavitating squamous cell carcinoma of the lung with hypercalcemia-leukocytosis syndrome CONCLUSION: There should be a high degree of suspicion to diagnose lung cancer in patients presenting with symptoms of paraneoplastic syndrome.

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(PMID = 19183491.001).

[ISSN] 1757-1626

[Journal-full-title] Cases journal

[ISO-abbreviation] Cases J

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC2646690

   

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