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1. Biomedical articles (top 50; 2010 to 2015)
1. George TI: Malignant or benign leukocytosis. Hematology Am Soc Hematol Educ Program; 2012;2012:475-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant or benign leukocytosis.
  • Leukocytosis, or elevated WBC count, is a commonly encountered laboratory finding.
  • Distinguishing malignant from benign leukocytosis is a critical step in the care of a patient, which initiates a vastly different decision tree.
  • Confirmation of the complete blood cell count and the WBC differential is the first step.
  • Examination of the PB smear is essential to confirming the automated blood cell differential or affirming the manual differential performed on the PB smear.
  • Next is separation of the leukocytosis into a myeloid versus a lymphoid process.
  • Distinguishing a reactive lymphoid proliferation from a lymphoproliferative disorder requires examination of lymphocyte morphology for pleomorphic lymphocytes versus a monomorphic population, with the latter favoring a lymphoproliferative neoplasm.
  • Samples suspicious for lymphoproliferative disorders can be confirmed and characterized by flow cytometry, with molecular studies initiated in select cases; precursor lymphoid neoplasms (lymphoblasts) should trigger a BM examination.
  • Myeloid leukocytosis triggers a differential diagnosis of myeloid leukemoid reactions versus myeloid malignancies.
  • Myeloid leukemoid reactions commonly result from infections and show activated neutrophil changes on morphology; these should prompt evaluation for infection.
  • Other causes of reactive myeloid leukocytoses are also discussed herein.
  • [MeSH-major] Cell Count / methods. Hematology / methods. Leukocytosis / diagnosis. Leukocytosis / therapy
  • [MeSH-minor] Algorithms. Automation. Bone Marrow Cells / cytology. Cell Proliferation. Cell Separation. Diagnosis, Differential. Flow Cytometry / methods. Humans. Leukemia, Myeloid / therapy. Leukemoid Reaction. Leukocyte Count. Leukocytes / cytology. Lymphocytes / cytology. Lymphoproliferative Disorders / blood. Lymphoproliferative Disorders / therapy. Myeloproliferative Disorders / diagnosis

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  • (PMID = 23233622.001).
  • [ISSN] 1520-4383
  • [Journal-full-title] Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
  • [ISO-abbreviation] Hematology Am Soc Hematol Educ Program
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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2. Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH: Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy. Thromb Res; 2010 Aug;126(2):113-8
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  • [Title] Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy.
  • BACKGROUND: Leukocytosis has been associated with thrombosis and mortality in cancer patients.
  • We explored the association of leukocytosis with venous thromboembolism (VTE) and early mortality in cancer patients initiating chemotherapy.
  • The association of leukocytosis, VTE and mortality during the course of chemotherapy was evaluated in univariate and multivariate analysis.
  • Of 4391 patients with available baseline white blood cell (WBC) count, 561 (12.8%) had elevated pretreatment leukocyte counts, defined as WBC > 11 x 10(9) cells/L.
  • VTE occurred in 25 of 561 patients (4.5%) with baseline leukocytosis compared to 68 of 3830 (1.8%) with WBC <or= 11 x 10(9) cells/L (P < 0.0001).
  • Baseline leukocytosis was associated with VTE by multivariate analysis as well (HR 2.1, 95% confidence interval 1.3-3.4, p = 0.003).
  • Forty one patients (7.3%) with leukocytosis died compared to 92 (2.4%) with WBC <or= 11 x 10(9) cells/L (P < 0.0001).
  • Baseline leukocytosis was associated with early mortality by multivariate analysis as well (HR 2.2, 95% confidence interval 1.5-3.3, p < 0.0001).
  • Mortality was greatest in patients with both leukocytosis and VTE.
  • In multivariate analysis several factors were predictive of leukocytosis.
  • CONCLUSIONS: Elevated WBC, particularly neutrophils, is strongly associated with increased risk of VTE and mortality in cancer patients receiving systemic chemotherapy.
  • [MeSH-major] Leukocytosis / complications. Neoplasms / complications. Neoplasms / drug therapy. Venous Thromboembolism / complications

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  • [Copyright] (c) 2010 Elsevier Ltd. All rights reserved.
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  • (PMID = 20684071.001).
  • [ISSN] 1879-2472
  • [Journal-full-title] Thrombosis research
  • [ISO-abbreviation] Thromb. Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / 1R01HL095109-01; United States / NCI NIH HHS / CA / K23 CA120587-01; United States / NHLBI NIH HHS / HL / R01 HL095109; United States / NCI NIH HHS / CA / UC2 CA148041
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS453607; NLM/ PMC3635827
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3. Grant R, Youm YH, Ravussin A, Dixit VD: Quantification of adipose tissue leukocytosis in obesity. Methods Mol Biol; 2013;1040:195-209
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  • [Title] Quantification of adipose tissue leukocytosis in obesity.
  • The infiltration of immune cell subsets in adipose tissue termed "adipose tissue leukocytosis" is a critical event in the development of chronic inflammation and obesity-associated comorbidities.
  • Given that a significant proportion of cells in adipose tissue of obese patients are of hematopoietic lineage, the distinct adipose depots represent an uncharacterized immunological organ that can impact metabolic functions.
  • Here, we describe approaches to characterize and isolate leukocytes from the complex adipose tissue microenvironment, to aid mechanistic studies to better understand the role of specific pattern recognition receptors (PRRs) such as inflammasomes in adipose-immune cross talk.
  • [MeSH-major] Adipose Tissue / pathology. Leukocytosis / diagnosis. Obesity / pathology
  • [MeSH-minor] Animals. Flow Cytometry. Humans. Immunophenotyping. Intra-Abdominal Fat / pathology. Leukocytes / cytology. Leukocytes / metabolism. Mice

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  • (PMID = 23852606.001).
  • [ISSN] 1940-6029
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / 8P20 GM103528; United States / NIA NIH HHS / AG / AG31797; United States / NIDDK NIH HHS / DK / DK090556; United States / NIDDK NIH HHS / DK / P30 DK072476; United States / NIDDK NIH HHS / DK / P30 DK072476; United States / NIA NIH HHS / AG / R01 AG031797; United States / NIDDK NIH HHS / DK / R01 DK090556; United States / NIDDK NIH HHS / DK / T32DK064584-10S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS567491; NLM/ PMC3972009
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4. Furer V, Raveh D, Picard E, Goldberg S, Izbicki G: Absence of leukocytosis in bacteraemic pneumococcal pneumonia. Prim Care Respir J; 2011 Sep;20(3):276-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Absence of leukocytosis in bacteraemic pneumococcal pneumonia.
  • BACKGROUND: Evaluation of patients with respiratory symptoms in primary care medicine is often based on peripheral WBC count that dictates the extent of diagnostic investigation.
  • A normal WBC count may result in a limited investigation, often omitting chest radiography.
  • AIMS: To determine the extent to which patients hospitalised with bacteraemic pneumococcal pneumonia have no leukocytosis at presentation.
  • RESULTS: 21% of the patients presented with a normal WBC count (16.7% of the children and 25.6% of the adults).
  • Among this population with a normal WBC count at presentation, 90% of the adults and 70% of the children developed leukocytosis within a few days after admission.
  • CONCLUSIONS: In this study, in as many as one-fifth of all the patients with bacteraemic pneumococcal pneumonia, there was no leukocytosis at presentation.
  • We therefore suggest that every patient with clinically suspected pneumonia should undergo chest radiography even if the WBC count is normal.
  • [MeSH-major] Bacteremia / blood. Bacteremia / diagnosis. Pneumonia, Pneumococcal / blood. Pneumonia, Pneumococcal / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Child, Preschool. Community-Acquired Infections / blood. Community-Acquired Infections / complications. Female. Humans. Infant. Leukocytosis / complications. Leukocytosis / epidemiology. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 21509416.001).
  • [ISSN] 1475-1534
  • [Journal-full-title] Primary care respiratory journal : journal of the General Practice Airways Group
  • [ISO-abbreviation] Prim Care Respir J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Cooper IF, Siadaty MS: 'Findings' associated with 'Leukocytosis Marked': Top Publications. BioMedLib Review; Finding;LeukocytosisMarked:707188305. ISSN: 2331-5717. 2014/10/6
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  • [Title] 'Findings' associated with 'Leukocytosis Marked': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Finding' for 'leukocytosis marked'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Finding'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 24 publications, and group two 808 publications.
  • Here are the top 10.
  • Murabe H et al: Anaplastic thyroid carcinoma with prominent cardiac metastasis, accompanied by a marked leukocytosis with a neutrophilia and high GM-CSF level in serum.
  • Shenkenberg TD et al: Erythrocytosis and marked leukocytosis in overlapping myeloproliferative diseases.
  • Gavrielatos G et al: Brugada electrocardiographic pattern induced during febrile state with marked leukocytosis.
  • Kobayashi T et al: [An autopsy case of colonic carcinoid with marked leukocytosis].
  • Khanna S et al: Infectious mononucleosis presenting as acute hepatitis, with marked leukocytosis and renal involvement.
  • Saito K et al: Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia.
  • Deibener-Kaminsky J et al: [Clinical relevance of leukocyte differential in patients with marked leukocytosis in the emergency room].
  • Morita T et al: Squamous cell carcinoma of the ureter with marked leukocytosis producing granulocyte colony-stimulating factor.
  • Chang R et al: Prognostic significance of marked leukocytosis in hospitalized patients.
  • Kubota Y: [A case of large-cell lung cancer with marked leukocytosis successfully treated with chemoradiotherapy].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707188305.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. Asadollahi K, Hastings IM, Beeching NJ, Gill GV, Asadollahi P: Leukocytosis as an alarming sign for mortality in patients hospitalized in general wards. Iran J Med Sci; 2011 Mar;36(1):45-9
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  • [Title] Leukocytosis as an alarming sign for mortality in patients hospitalized in general wards.
  • There is some evidence that leukocytosis without infection is associated with increased hospital mortality, but data in this regard are very incomplete.
  • This study was designed to investigate the relationship between leukocytosis at the time of admission and mortality among patients hospitalized in general wards.
  • During July to Nov 2004, all deceased patients who had a white blood cell (WBC) count record for the first 24 hours of admission were selected as cases.
  • Among survivors, twice the number of cases was selected as controls.
  • Different levels of WBC counts were compared between cases and controls.
  • The median WBC for deceased and surviving patients was 9.4 and 11.4×10(9)/l, respectively.
  • Patients with a WBC >10×10(9)/l accounted for 804, among which 335 (42%) were deceased.
  • Leukocytosis and leukopoenia were more frequent among the deceased patients compared to the survivors.
  • The likelihood ratio for leukocytosis and leukopenia among the cases and controls was 1.4 and 2.3, respectively.
  • Leukocytosis was identified as an alarming sign for mortality among patients admitted to general hospital wards at early stages of admission.
  • A quick medical intervention for amendment of the causes related to leukocytosis should consequently reduce hospital mortality.

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  • (PMID = 23365478.001).
  • [ISSN] 0253-0716
  • [Journal-full-title] Iranian journal of medical sciences
  • [ISO-abbreviation] Iran J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3559113
  • [Keywords] NOTNLM ; General hospital / hospital mortality / inpatient / leukocytosis
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7. Ohsawa I, Nagamachi S, Suzuki H, Honda D, Sato N, Ohi H, Horikoshi S, Tomino Y: Leukocytosis and high hematocrit levels during abdominal attacks of hereditary angioedema. BMC Gastroenterol; 2013;13:123
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  • [Title] Leukocytosis and high hematocrit levels during abdominal attacks of hereditary angioedema.
  • BACKGROUND: The diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness of this condition.
  • The correct diagnosis of HAE was made 22.7 ± 14.2 years after the initial symptoms.
  • In the patients with severe abdominal pain, significant leukocytosis with neutrophilia along with increased levels of hematocrit were observed while levels of C-reactive protein (CRP) remained low.
  • CONCLUSIONS: Consideration of the likelihood of a HAE attack is important when patients present with acute abdominal pain and leukocytosis without elevation of CRP.
  • [MeSH-major] Abdominal Pain / etiology. Angioedemas, Hereditary / blood. Angioedemas, Hereditary / diagnosis. Delayed Diagnosis. Leukocytosis / etiology

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  • (PMID = 23915279.001).
  • [ISSN] 1471-230X
  • [Journal-full-title] BMC gastroenterology
  • [ISO-abbreviation] BMC Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Complement C1 Inhibitor Protein; 0 / Complement Inactivating Agents; 9007-41-4 / C-Reactive Protein
  • [Other-IDs] NLM/ PMC3735392
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8. Jia J, Ren J, Gu J, Di L, Song G: Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis. Rare Tumors; 2010;2(3):e44
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  • [Title] Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis.
  • Sarcomatoid carcinoma is an extremely rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells.
  • Limited data on sarcomatoid carcinoma showed that most cases occurred with advanced local disease and metastasis, and paraneoplastic syndromes were rare.
  • We present the case of a 63-year-old man with lung sarcomatoid carcinoma associated with jejunum metastasis and leukocytosis, and its clinical, macroscopic, and histopathological features.
  • This case emphasizes the importance of recognizing paraneoplastic syndromes and metastasis of sarcomatoid carcinoma at diagnosis.

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  • (PMID = 21139960.001).
  • [ISSN] 2036-3613
  • [Journal-full-title] Rare tumors
  • [ISO-abbreviation] Rare Tumors
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC2994519
  • [Keywords] NOTNLM ; leukocytosis / lung cancer / sarcomatoid carcinoma
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9. Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Leukocytosis Chronic': Top Publications. BioMedLib Review; DiseaseOrSyndrome;LeukocytosisChronic:706226737. ISSN: 2331-5717. 2014/1/24
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  • [Title] 'Diseases or Syndromes' associated with 'Leukocytosis Chronic': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'leukocytosis chronic'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 1259 publications.
  • Here are the top 10.
  • Gatti RA et al: Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy.
  • McCreary PA et al: Leukocytosis, bone marrow hyperplasia and leukemia in chronic magnesium deficiency in the rat.
  • Gorski TF et al: Correlation of pseudohypoxemia and leukocytosis in chronic lymphocytic leukemia.
  • Yamauchi K et al: Spontaneous remission with cyclic leukocytosis in chronic myelogenous leukemia.
  • D'IACHENKO DP: [Local leukocytosis in chronic tonsillitis].
  • Fukasawa H et al: Pseudohyperkalemia occurring in a patient with chronic renal failure and polycythemia vera without severe leukocytosis or thrombocytosis.
  • Rodriguez AR et al: Marked cyclic leukocytosis-leukopenia in chronic myelogenous leukemia.
  • Takimoto Y et al: [Chronic myelomonocytic leukemia with repeated respiratory failure associated with leukocytosis following splenic arterial embolization and splenectomy].
  • Erlinger TP et al: Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults.
  • Grinblat J et al: Chronic myelogenous leukemia with elevated leukocyte alkaline phosphatase, positive indirect Coombs' test, neutrophilic leukocytosis and unusual cytogenetical findings.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706226737.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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10. Chabot-Richards DS, George TI: Leukocytosis. Int J Lab Hematol; 2014 Jun;36(3):279-88
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leukocytosis.
  • An increased white blood cell count, or leukocytosis, is a common laboratory finding.
  • Appropriate specimen evaluation depends on which lineages are increased and the morphologic findings on peripheral blood smear review to guide further testing.
  • Myeloid leukocytosis can occur in a number of reactive conditions as well as myeloid malignancies.
  • The types of cells present and morphology can help to guide additional workup.
  • This study provides guidance for the appropriate evaluation and further workup of leukocytosis.
  • [MeSH-major] Leukocytosis / diagnosis. Leukocytosis / etiology
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Humans. Leukocyte Count. Leukocytes / cytology. Leukocytes / pathology. Lymphocytosis / diagnosis. Lymphocytosis / etiology

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  • [Copyright] © 2014 John Wiley & Sons Ltd.
  • (PMID = 24750674.001).
  • [ISSN] 1751-553X
  • [Journal-full-title] International journal of laboratory hematology
  • [ISO-abbreviation] Int J Lab Hematol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Keywords] NOTNLM ; Leukocytosis / lymphocytosis / lymphoma / morphology / neutrophilia
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11. Fonda P, de Santiago E, Guijarro M, Gamallo C: Mediastinal myelolipoma with leukocytosis. BMJ Case Rep; 2013;2013
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mediastinal myelolipoma with leukocytosis.
  • We report the case of a 64-year-old woman who presented a heterogeneous 1.4×2.5×3 cm paravertebral thoracic mass detected by chest tomography during the study of a leukocytosis of unknown aetiology.
  • The CT findings and pathology revealed the diagnosis of myelolipoma.
  • [MeSH-major] Leukocytosis / complications. Mediastinal Neoplasms / diagnosis. Myelolipoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 23813520.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. Worley MJ Jr, Nitschmann CC, Shoni M, Vitonis AF, Rauh-Hain JA, Feltmate CM: The significance of preoperative leukocytosis in endometrial carcinoma. Gynecol Oncol; 2012 Jun;125(3):561-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The significance of preoperative leukocytosis in endometrial carcinoma.
  • OBJECTIVE: To evaluate the impact of preoperative leukocytosis among patients with endometrial carcinoma.
  • Patients were separated into two groups based on the presence or absence of preoperative leukocytosis (WBC ≥ 10,000 cells per μl).
  • RESULTS: 1144 patients were identified, 156 (13.6%) with preoperative leukocytosis and 988 (86.4%) without leukocytosis.
  • The leukocytosis group had a greater percentage of patients with stage 3 (15.4% vs. 9.8%, crude p=0.02) and 4 (7.1% vs. 3.0%, crude p=0.007) disease.
  • Leukocytosis was associated with a greater mean tumor size (4.4 vs. 3.4 cm, p=0.0002) and a greater percentage of patients with cervical stromal involvement (14.8% vs. 8.7%, crude p=0.02), adnexal involvement (14.1% vs. 7.5%, crude p=0.007) and lymphvascular space invasion (24% vs. 16.3%, crude p=0.02).
  • On multivariate analysis, mean tumor size (OR, 95% CI; 1.10, 1.02-1.18) remained significantly associated with preoperative leukocytosis.
  • However, leukocytosis was independently associated with an increased risk of death (HR, 95% CI; 1.69, 1.07-2.68).
  • CONCLUSIONS: Preoperative leukocytosis, among endometrial cancer patients, was independently associated with increasing tumor size and independently imposed an increased risk of death.
  • [MeSH-major] Endometrial Neoplasms / blood. Endometrial Neoplasms / surgery. Leukocytosis / complications

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
  • (PMID = 22465698.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. Kuznik BI, Morozova IIu, Rodnina OS, Strambovskaia NN, Shirshov IuA: [Leukocytosis and outcomes of acute stroke]. Zh Nevrol Psikhiatr Im S S Korsakova; 2010;110(3):10-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Leukocytosis and outcomes of acute stroke].
  • We carried out the retrospective analysis of 300 disease histories of patients with stroke hospitalized in the first 24 h of the disease.
  • The presence of leukocytosis and its severity were evaluated as predictors of outcome.
  • The level of leukocyte-erythrocyte aggregations in the blood film was determined in some patients.
  • The analysis revealed that the higher was leukocytosis, the more severe was the course of stroke and the higher was frequency of fatal outcomes.
  • Patients with stroke more often had neutrophilic leukocytosis than monocytosis, the former was the predictor of worse prognosis.
  • The most unfavorable prognosis was observed in patients with hemorrhagic stroke and leukocytosis.
  • The higher was the number of leukocytes, the higher was the probability of fatal outcome in the first month of stroke.
  • The level of leukocyte-erythrocyte aggregations dramatically increased in the blood of stroke patients that promoted the disturbance of microcirculation and worsened significantly the disease prognosis.
  • [MeSH-major] Leukocytosis / blood. Leukocytosis / etiology. Stroke / blood. Stroke / mortality
  • [MeSH-minor] Female. Humans. Leukocyte Count. Male. Monocytes. Neutrophils. Prognosis. Retrospective Studies

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  • (PMID = 20517219.001).
  • [ISSN] 1997-7298
  • [Journal-full-title] Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov
  • [ISO-abbreviation] Zh Nevrol Psikhiatr Im S S Korsakova
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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14. Salimi S, Ng N, Seliger SL, Parsa A: Periodontal disease, renal dysfunction and heightened leukocytosis. Nephron Clin Pract; 2014;128(1-2):107-14
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  • [Title] Periodontal disease, renal dysfunction and heightened leukocytosis.
  • BACKGROUND: Leukocytosis is a powerful predictor of incident chronic kidney disease (CKD) and related outcomes.
  • However, the association between periodontitis measures and increased leukocytosis in the context of CKD has not been well described.
  • We sought to identify which individual measures of periodontal disease may best associate with reduced estimated glomerular filtration rate (eGFR) and albuminuria, and to test if these measures were associated with increased leukocytosis in subjects with established CKD.
  • METHODS: We estimated, among 13,270 participants in the National Health and Nutrition Examination Survey III study, the associations between case-based definition of periodontitis, clinical attachment loss (CAL) and pocket depth (PD) as individual measures of periodontal disease, with renal function measures and leukocytosis.
  • RESULTS: In adjusted multivariate analyses, case-based definition of severe periodontitis was associated with albuminuria (β = 0.003, p = 0.01) but not with eGFR.
  • We found significant associations between elevated CAL and PD with leukocytosis.
  • Lastly, we found a marked association between the joint presence of CKD and elevated CAL or PD with leukocytosis (odds ratio (OR) 3.3, 95% confidence interval (CI) 1.4-7.5 and OR 3.2, 95% CI 1.1-9.7, respectively).
  • CONCLUSION: Individual measures of periodontal disease are associated with renal function and heightened leukocytosis in CKD subjects.
  • The significantly added inflammatory burden noted in CKD subjects with periodontal disease argue for targeting periodontitis treatment as part of our multifaceted approach to CKD patients.

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  • [Copyright] © 2014 S. Karger AG, Basel
  • (PMID = 25402594.001).
  • [ISSN] 1660-2110
  • [Journal-full-title] Nephron. Clinical practice
  • [ISO-abbreviation] Nephron Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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15. Cerny J, Rosmarin AG: Why does my patient have leukocytosis? Hematol Oncol Clin North Am; 2012 Apr;26(2):303-19, viii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Why does my patient have leukocytosis?
  • Leukocytosis is one of the most common laboratory abnormalities in medicine, and one of the most frequent reasons for hematologic consultation.
  • Effective evaluation of leukocytosis requires an attentive history, careful physical examination, meticulous review of the complete blood count and peripheral blood smear, judicious application of laboratory and radiologic testing, and thoughtful analysis.
  • Definitive diagnosis may require bone marrow aspiration and biopsy, imaging studies, and specialized molecular tests.
  • The differential diagnosis of leukocytosis includes physiologic responses to a broad range of infectious and inflammatory processes, as well as numerous primary hematologic disorders such as leukemias, lymphomas, and myeloproliferative neoplasms.
  • [MeSH-major] Leukocytosis / etiology
  • [MeSH-minor] Cell Differentiation. Humans. Leukocytes / cytology. Leukocytes / metabolism

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22463829.001).
  • [ISSN] 1558-1977
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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16. Njølstad TS, Engerud H, Werner HM, Salvesen HB, Trovik J: Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas. Gynecol Oncol; 2013 Nov;131(2):410-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas.
  • OBJECTIVES: The objective of this study is to investigate preoperative hematological parameters for anemia, leukocytosis and thrombocytosis in relation to established prognostic factors and survival in endometrial cancer.
  • METHODS: 557 patients treated for endometrial carcinoma were prospectively included in a study focusing on the relationship between preoperative hemoglobin, leukocyte and platelet counts, and a panel of clinicopathological characteristics and outcome.
  • RESULTS: Preoperative anemia was present in 15.8%, leukocytosis in 11.2% and thrombocytosis in 12.1%.
  • Among patients with localized disease (FIGO stage I/II), 18.1% had anemia and/or thrombocytosis at diagnosis.
  • Patients with advanced disease (high FIGO stage and lymph-node metastasis) had significantly lower hemoglobin count, higher leukocyte count and higher platelet count (all p<0.008).
  • Patients with anemia, leukocytosis and thrombocytosis had significantly shorter 5-year disease-specific survival of 61.3%, 66.0% and 61.0% respectively, compared to 87.7%, 86.3% and 87.3% for patients with normal counts (all p<0.001).
  • CONCLUSION: Preoperative anemia, leukocytosis or thrombocytosis in women with endometrial carcinoma is associated with advanced disease and poor disease-specific survival.
  • [MeSH-major] Anemia / etiology. Endometrial Neoplasms / blood. Leukocytosis / etiology. Thrombocytosis / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cohort Studies. Female. Hemoglobins / metabolism. Humans. Leukocyte Count. Middle Aged. Platelet Count. Preoperative Period. Prognosis. Proportional Hazards Models. Young Adult

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  • [Copyright] © 2013.
  • (PMID = 24004646.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hemoglobins
  • [Keywords] NOTNLM ; Endometrial cancer / Leukocytosis / Preoperative anemia / Prognosis / Thrombocytosis
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17. Cooper IF, Siadaty MS: 'Neoplastic Processes' associated with 'Leukocytosis Chronic': Top Publications. BioMedLib Review; NeoplasticProcess;LeukocytosisChronic:706558751. ISSN: 2331-5717. 2014/6/28
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  • [Title] 'Neoplastic Processes' associated with 'Leukocytosis Chronic': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Neoplastic Process' for 'leukocytosis chronic'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Neoplastic Process'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 1044 publications.
  • Here are the top 10.
  • Gatti RA et al: Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy.
  • Morita Y et al: A case of chronic myelomonocytic leukemia who developed pericardial effusion during stably controlled leukocytosis.
  • Basmaci M et al: Chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis.
  • Neureiter D et al: Differential diagnostic challenge of chronic neutrophilic leukemia in a patient with prolonged leukocytosis.
  • Raut LS et al: Comments on chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis.
  • Gorski TF et al: Correlation of pseudohypoxemia and leukocytosis in chronic lymphocytic leukemia.
  • Yamauchi K et al: Spontaneous remission with cyclic leukocytosis in chronic myelogenous leukemia.
  • Grinblat J et al: Chronic myelogenous leukemia with elevated leukocyte alkaline phosphatase, positive indirect Coombs' test, neutrophilic leukocytosis and unusual cytogenetical findings.
  • Rodriguez AR et al: Marked cyclic leukocytosis-leukopenia in chronic myelogenous leukemia.
  • Kyathari S et al: Severe imatinib-associated muscle edema in patients with chronic myelogenous leukemia and marked leukocytosis.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706558751.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. Cooper IF, Siadaty MS: 'Qualitative Concepts' associated with 'Leukocytosis Chronic': Top Publications. BioMedLib Review; QualitativeConcept;LeukocytosisChronic:706237311. ISSN: 2331-5717. 2014/9/24
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  • [Title] 'Qualitative Concepts' associated with 'Leukocytosis Chronic': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Qualitative Concept' for 'leukocytosis chronic'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Qualitative Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 1230 publications.
  • Here are the top 10.
  • Gatti RA et al: Cyclic leukocytosis in chronic myelogenous leukemia: new perspectives on pathogenesis and therapy.
  • Basmaci M et al: Chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis.
  • Raut LS et al: Comments on chronic subdural hematoma in a child with acute myeloid leukemia after leukocytosis.
  • Gorski TF et al: Correlation of pseudohypoxemia and leukocytosis in chronic lymphocytic leukemia.
  • Yamauchi K et al: Spontaneous remission with cyclic leukocytosis in chronic myelogenous leukemia.
  • Sopko MA et al: Chronic leukocytosis associated with clozapine treatment.
  • Caramazza D et al: Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.
  • Rodriguez AR et al: Marked cyclic leukocytosis-leukopenia in chronic myelogenous leukemia.
  • Inbal A et al: Cyclic leukocytosis and long survival in chronic myeloid leukemia.
  • Takimoto Y et al: [Chronic myelomonocytic leukemia with repeated respiratory failure associated with leukocytosis following splenic arterial embolization and splenectomy].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706237311.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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19. Aqil B, Green LK, Lai S: Primary splenic angiosarcoma associated with anemia, leukocytosis and thrombocytopenia. Ann Clin Lab Sci; 2014;44(2):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary splenic angiosarcoma associated with anemia, leukocytosis and thrombocytopenia.
  • Primary angiosarcoma of the spleen is a rare neoplasm arising from endothelial cells.
  • We report a case of 61-year-old Caucasian man who presented with shortness of breath, anemia, leukocytosis, and thrombocytopenia.
  • Image-guided Fine Needle Aspiration (FNA) revealed an atypical spindle cell lesion.
  • The patient appeared disease free after resection.
  • [MeSH-major] Anemia / complications. Hemangiosarcoma / complications. Leukocytosis / complications. Splenic Neoplasms / complications. Thrombocytopenia / complications

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  • (PMID = 24795063.001).
  • [ISSN] 1550-8080
  • [Journal-full-title] Annals of clinical and laboratory science
  • [ISO-abbreviation] Ann. Clin. Lab. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Ishii T, Sakamoto A, Matsuda S, Matsumoto Y, Harimaya K, Takahashi Y, Oda Y, Iwamoto Y: Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF. Skeletal Radiol; 2012 Jun;41(6):719-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSF.
  • Leukocytosis associated with secretion of granulocyte colony-stimulating factor (G-CSF) has been reported in various tumors, primarily poorly differentiated epithelial tumors, but is extremely rare in bone tumors.
  • Leukocytosis and elevated serum G-CSF were observed, but resolved following tumor resection.
  • A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically.
  • Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors.
  • [MeSH-major] Bone Neoplasms / diagnosis. Granulocyte Colony-Stimulating Factor / blood. Humerus / pathology. Leiomyosarcoma / diagnosis. Leukocytosis / blood. Leukocytosis / diagnosis

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  • (PMID = 22167228.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 143011-72-7 / Granulocyte Colony-Stimulating Factor
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21. Saaiq M, Niaz-Ud-Din, Jalil A, Zubair M, Shah SA: Diagnostic accuracy of leukocytosis in prediction of acute appendicitis. J Coll Physicians Surg Pak; 2014 Jan;24(1):67-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic accuracy of leukocytosis in prediction of acute appendicitis.
  • An analytical study was conducted to find out the diagnostic accuracy of leukocytosis in predicting acute appendicitis in patients undergoing emergency appendicectomy.
  • The operative findings were correlated with leukocyte counts using 2 x 2 table.
  • Out of 233 appendicectomies, with exclusion of the negative appendicectomies (17.59%, n = 41), there were 67.38% patients (n = 157) with elevated leukocyte count.
  • The overall sensitivity, specificity, positive predictive value and negative predictive value of elevated leukocyte counts for inflamed appendix were 91.81%, 43.55%, 81.77% and 65.85% respectively.
  • [MeSH-major] Appendicitis / diagnosis. Appendicitis / surgery. Inflammation / complications. Leukocytosis / diagnosis
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Aged. Appendectomy. C-Reactive Protein / analysis. Child. Female. Flank Pain / etiology. Humans. Leukocyte Count. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 24411549.001).
  • [ISSN] 1681-7168
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Pakistan
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
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22. Munoz J, Guo Y: Leukocytosis: the mysteries within. Am J Hematol; 2012 Feb;87(2):197
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Leukocytosis: the mysteries within.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Benzamides / therapeutic use. Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis. Leukocytosis / diagnosis. Piperazines / therapeutic use. Pyrimidines / therapeutic use
  • [MeSH-minor] Aged. Humans. Leukocyte Count. Male. Remission Induction

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  • (PMID = 21815181.001).
  • [ISSN] 1096-8652
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; BKJ8M8G5HI / imatinib
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23. Kondoh E, Shimizu M, Kakui K, Mikami Y, Tatsumi K, Konishi I: Deciduosis can cause remarkable leukocytosis and obscure abdominal pain. J Obstet Gynaecol Res; 2012 Dec;38(12):1376-8
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  • [Title] Deciduosis can cause remarkable leukocytosis and obscure abdominal pain.
  • Remarkable leukocytosis with obscure abdominal pain during pregnancy is clinically challenging for obstetricians.
  • A 31-year-old pregnant woman developed persistently elevated white blood cell (approximately 30 000/µL) and C-reactive protein (3.0 mg/dL) with occasional moderate abdominal pain.
  • White blood cells rose 87200/µL, and C-reactive protein peaked at 44.9mg/dL after surgery.
  • Pathologically, biopsies showed deciduosis, and decidual cells on the omental surface showed immunohistochemical staining for granulocyte colony-stimulating factor (G-CSF).
  • G-CSF-producing deciduosis can induce leukocytosis as well as abdominal pain during pregnancy and postpartum.
  • [MeSH-major] Abdominal Pain / etiology. Leukocytosis / etiology. Pregnancy Complications / immunology

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  • [Copyright] © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.
  • (PMID = 22612308.001).
  • [ISSN] 1447-0756
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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24. Paul DA, Zook K, Mackley A, Locke RG: Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants. J Perinatol; 2010 Jan;30(1):58-62
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  • [Title] Reduced mortality and increased BPD with histological chorioamnionitis and leukocytosis in very-low-birth-weight infants.
  • OBJECTIVE: To investigate the association between leukocytosis, mortality and bronchopulmonary dysplasia (BPD) in very-low-birth-weight infants (VLBW) born to mothers with histological chorioamnionitis.
  • Total white blood cells (WBCs) after birth were measured.
  • Leukocytosis was defined as a total WBC count >30 000 per mm(3) in the first 2 days of life.
  • RESULT: After controlling for potential confounding variables, infants who developed a leukocytosis after birth had increased odds of BPD (4.6, 95% confidence interval (95% CI): 2.0 to 10.3), but decreased odds of death (0.3, 95% CI: 0.1 to 0.90).
  • CONCLUSION: In our population of VLBW infants born to mothers with histological chorioamnionitis, leukocytosis after birth is associated with a decrease in mortality but an increase in BPD.
  • [MeSH-major] Bronchopulmonary Dysplasia / blood. Chorioamnionitis / mortality. Infant, Very Low Birth Weight / blood. Leukocytosis / complications

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  • (PMID = 19710675.001).
  • [ISSN] 1476-5543
  • [Journal-full-title] Journal of perinatology : official journal of the California Perinatal Association
  • [ISO-abbreviation] J Perinatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Sopko MA, Caley CF: Chronic leukocytosis associated with clozapine treatment. Clin Schizophr Relat Psychoses; 2010 Jul;4(2):141-4
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  • [Title] Chronic leukocytosis associated with clozapine treatment.
  • Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns.
  • Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC).
  • In some of these patients, the leukocytosis may be persistent.
  • We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis.
  • A brief review of the literature addressing clozapine-associated leukocytosis follows the case report.
  • [MeSH-major] Antipsychotic Agents / adverse effects. Clozapine / adverse effects. Leukocytosis / chemically induced. Schizophrenia, Paranoid / drug therapy
  • [MeSH-minor] Adult. Chronic Disease. Dose-Response Relationship, Drug. Drug Therapy, Combination. Humans. Leukocyte Count. Male

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  • (PMID = 20643637.001).
  • [ISSN] 1935-1232
  • [Journal-full-title] Clinical schizophrenia & related psychoses
  • [ISO-abbreviation] Clin Schizophr Relat Psychoses
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antipsychotic Agents; J60AR2IKIC / Clozapine
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26. [Iron metabolism regulatory mechanisms in initial leukocytosis in patients with acute leukemia]. Ter Arkh; 2011;83(10):22-7
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  • [Title] [Iron metabolism regulatory mechanisms in initial leukocytosis in patients with acute leukemia].
  • AIM: To study levels of hepsidine (Hp), hypoxia-inducible factor-1alpha (HIF-1alpha), erythropoietin (EP) and ferritin in patients with acute leukemia (AL), effects of protein fractions of homogenate of blastic cells (BC) on regulatory proteins studied.
  • MATERIAL AND METHODS: Depending on leukocyte count in the onset of AL, 70 patients with first ever diagnosed AL were divided into two groups: group 1 - 17 patients with leukocyte count > 30 x 10(9)/l, group 2 - 53 patients with leukocyte count < 30 x 10(9)/l.
  • Serum and leukocyte parameters were studied before treatment, during the treatment with cytostatic drugs, in the course of myelotoxic agranulocytosis (MTA), after normalization of hemograms.
  • EP was detected with enzyme immunoassay, serum and leukocyte ferritin - with radioimmunoassay; HIF-1alpha, Hp - sandwich enzyme immunoassay using monospecific antisera and monoclonal antibodies against relevant antigens.
  • Leukocytes were isolated in ficol and verografin solutions density gradient.
  • Chromatographic division of the protein fractions in 3 patients with leukocytosis in AL onset and leukocytes of 3 donors was made by the method of preparative isoelectrofocusing of BC and leukocytes on LKB colon (Sweden).
  • RESULTS: Leukocytosis patients with initial AL have serum ferritin, Hp and HIF-1alpha levels about 2-5 times lower than patients without leukocytosis.
  • It is detected that protein fractions isolated from leukocytes of patients with leukocytosis in the disease onset raise HIF-1alpha content irrespective of HIF-1alpha presence in the fraction.
  • CONCLUSION: Great difficulties exist in ferritin and Hp levels between AL patients with leukocytosis in the onset of the disease and without of leukocytosis.
  • The study of leukocytes suggests that tumor cells of such patients contain compounds which can regulate production of HIF-1alpha, Hp and ferritin.
  • [MeSH-major] Iron / metabolism. Leukemia / blood. Leukocytosis / blood
  • [MeSH-minor] Acute Disease. Erythropoietin / blood. Erythropoietin / metabolism. Ferritins / blood. Ferritins / metabolism. Humans. Hypoxia-Inducible Factor 1, alpha Subunit / blood. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Radioimmunoassay

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  • (PMID = 22185020.001).
  • [ISSN] 0040-3660
  • [Journal-full-title] Terapevticheskiĭ arkhiv
  • [ISO-abbreviation] Ter. Arkh.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 11096-26-7 / Erythropoietin; 9007-73-2 / Ferritins; E1UOL152H7 / Iron
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27. Worley MJ Jr, Nitschmann CC, Shoni M, Rauh-Hain JA, Williams KA, Feltmate CM: Preoperative leukocytosis imposes an increased risk of recurrence and death among patients with nonendometrioid endometrial carcinoma. Int J Gynecol Cancer; 2013 Feb;23(2):312-7
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  • [Title] Preoperative leukocytosis imposes an increased risk of recurrence and death among patients with nonendometrioid endometrial carcinoma.
  • OBJECTIVE: To evaluate the impact of preoperative leukocytosis among patients with nonendometrioid endometrial carcinoma.
  • The patients were separated into 2 groups based on the presence or absence of preoperative leukocytosis (white blood cell count ≥ 10,000/μL).
  • RESULTS: A total of 222 patients were identified, and preoperative leukocytosis was observed in 33 patients (14.9%).
  • The leukocytosis group was associated with a larger mean size of the primary tumor (6.8 vs 4.6 cm, P = 0.016) and a greater percentage of patients with cervical stromal involvement (36.4% vs 20.1%, P = 0.039), adnexal involvement (42.4% vs. 22.8%, P = 0.017), and pelvic/para-aortic lymph node involvement (50% vs 27.4%, P = 0.025).
  • On multivariate analysis, preoperative leukocytosis was independently associated with an increased risk of recurrence (hazard ratio, 2.07; 95% confidence interval, 1.12-3.84) and an increased risk of death (hazard ratio, 3.33; 95% confidence interval, 2.01-5.53).
  • CONCLUSIONS: Among patients with nonendometrioid endometrial carcinoma, preoperative leukocytosis is independently associated with an increased risk of recurrence and death.
  • [MeSH-major] Endometrial Neoplasms / diagnosis. Endometrial Neoplasms / mortality. Leukocytosis / diagnosis

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  • (PMID = 23358179.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Petterino C, Luzio E, Baracchini L, Ferrari A, Ratto A: Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol; 2011 Mar;40(1):89-94
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  • [Title] Paraneoplastic leukocytosis in a dog with a renal carcinoma.
  • Nonregenerative anemia, mild leukocytosis, marked hypoalbuminemia, and hematuria were observed.
  • Cytologic examination of fine-needle aspirates and imprints of the right kidney revealed a neoplastic cell population suggestive of renal carcinoma.
  • The histopathologic diagnosis was chromophobic cystic-papillary renal carcinoma.
  • The tumor cells expressed granulocytic/macrophage-colony-stimulating factor (GM-CSF), detected by immunohistochemical staining, and elaboration of GM-CSF by the tumor may have mediated the leukocytosis in this dog.
  • Following excision of the tumor, neutrophil and monocyte counts were only mildly increased.
  • The dog died 135 days after initial presentation, and a necropsy was not permitted.
  • Paraneoplastic neutrophilic leukocytosis is an uncommon finding and may be caused by elaboration of CSF by neoplastic cells.
  • [MeSH-major] Carcinoma, Renal Cell / veterinary. Dog Diseases / pathology. Kidney Neoplasms / veterinary. Leukocytosis / veterinary. Paraneoplastic Syndromes / veterinary

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  • [Copyright] ©2011 American Society for Veterinary Clinical Pathology.
  • [CommentIn] Vet Clin Pathol. 2011 Jun;40(2):137; author reply 137 [21631565.001]
  • (PMID = 21291490.001).
  • [ISSN] 1939-165X
  • [Journal-full-title] Veterinary clinical pathology / American Society for Veterinary Clinical Pathology
  • [ISO-abbreviation] Vet Clin Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
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29. Cooper ES, Berry MP, McMurray RG, Hosick PA, Hackney AC: Core temperature influences on the relationship between exercise-induced leukocytosis and cortisol or TNF-alpha. Aviat Space Environ Med; 2010 May;81(5):460-6
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  • [Title] Core temperature influences on the relationship between exercise-induced leukocytosis and cortisol or TNF-alpha.
  • INTRODUCTION: The extent to which exercise in the heat modifies leukocytosis and the relationship between the leukocytosis and tumor necrosis factor-alpha (TNF-alpha) or cortisol is not well understood.
  • Thus, this study attempted to determine the combined effect of exercise and differing elevations in core temperature on exercise-induced leukocytosis and to examine associations between any leukocytosis and cortisol orTNF-alpha.
  • Leukocytes, TNF-alpha, and cortisol were determined at baseline, immediately post-, and 2 h post-exercise.
  • RESULTS: Both trials resulted in significant 13-33% increases in total leukocytes, mostly driven by a 24-30% increase in neutrophils.
  • A significant relationship was found between the change in core temperature (T(re)) during exercise and the increase in total leukocytes (r = 0.561).
  • Yet the exercise-induced change in cortisol was not significantly correlated to any changes in leukocytes.
  • There was a trend for the relationships between the exercise-induced change in TNF-alpha and the changes in total leukocytes (r = 0.491) and neutrophils (r = 0.479).
  • DISCUSSION: These results suggest that although neither cortisol nor TNF-alpha are strong predictors of the leukocyte response during exercise or recovery, each factor may be one of many potential modifiers of the total leukocyte response.
  • [MeSH-major] Body Temperature / physiology. Exercise / physiology. Hot Temperature. Hydrocortisone / blood. Leukocytosis. Tumor Necrosis Factor-alpha / blood

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  • (PMID = 20464812.001).
  • [ISSN] 0095-6562
  • [Journal-full-title] Aviation, space, and environmental medicine
  • [ISO-abbreviation] Aviat Space Environ Med
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; WI4X0X7BPJ / Hydrocortisone
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30. Boehme AK, Kumar AD, Lyerly MJ, Gillette MA, Siegler JE, Albright KC, Beasley TM, Martin-Schild S: Persistent leukocytosis-is this a persistent problem for patients with acute ischemic stroke? J Stroke Cerebrovasc Dis; 2014 Aug;23(7):1939-43
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  • [Title] Persistent leukocytosis-is this a persistent problem for patients with acute ischemic stroke?
  • BACKGROUND: In the setting of acute ischemic stroke (AIS), leukocytosis has been shown to be an indicator of inflammatory response.
  • Although leukocytosis on admission has been shown to correlate with initial stroke severity in AIS patients, no work has been done to assess if there are differences in transient or persistent leukocytosis in patients without infection.
  • The objective of this study is to determine the clinical significance of persistent versus transient leukocytosis during the early phase of AIS.
  • Patients were included if they had leukocytosis on admission (defined as white blood cell count >11,000/μL based on laboratory reference range values).
  • A logistic regression model was used to evaluate persistent leukocytosis (leukocytosis 48 hours after admission) as a predictor of several outcome measures, including good functional outcome (discharge modified Rankin Scale score of 0-2).
  • RESULTS: Of the 438 patients screened, 49 had leukocytosis on admission and of those 24 (49%) had persistent leukocytosis.
  • NIHSS score correlated significantly with persistence of leukocytosis (r = .306; P = .0044).
  • More people with transient leukocytosis (leukocytosis lasting <48 hours) had a good functional outcome (44% versus 16%; P = .006).
  • After adjusting for baseline NIHSS score, persistent leukocytosis was not a significant independent predictor of good functional outcome, but showed an association (OR, 2.5; 95% CI, .562-10.7; P = .2322).
  • Persistent leukocytosis after adjusting for age and NIHSS score at admission is associated with a poor functional outcome, but it is not statistically significant (OR, 2.43; 95% CI, .59-9.87; P = .2151).
  • After controlling for age and NIHSS score on admission, for patients with persistent leukocytosis, the probability of having poor functional outcome at discharge was increased by 16 percentage points.
  • CONCLUSIONS: Persistent leukocytosis is associated with higher baseline NIHSS scores.
  • Persistent leukocytosis is tightly linked with baseline stroke severity and is associated with poor patient outcomes.
  • Our study found that patients with persistent leukocytosis are more likely to present with severe strokes and maintain a high NIHSS score at 24 hours after admission, unlike patients without leukocytosis or patients with transient leukocytosis.
  • Furthermore, it appears that persistent leukocytosis outside the setting of an infection negatively impacts the short-term functional outcome of AIS patients.
  •  Identifying patients with persistent leukocytosis could help to prognosticate and target patients that may benefit from future anti-inflammatory interventions.
  • [MeSH-major] Brain Ischemia / complications. Leukocytosis / complications. Stroke / complications

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  • [Copyright] Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
  • (PMID = 24784010.001).
  • [ISSN] 1532-8511
  • [Journal-full-title] Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • [ISO-abbreviation] J Stroke Cerebrovasc Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.68 / Tissue Plasminogen Activator
  • [Keywords] NOTNLM ; Leukocyte / inflammation / ischemic stroke / stroke care
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31. Qiu MZ, Xu RH, Ruan DY, Li ZH, Luo HY, Teng KY, Wang ZQ, Li YH, Jiang WQ: Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China. Tumour Biol; 2010 Dec;31(6):633-41
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  • [Title] Incidence of anemia, leukocytosis, and thrombocytosis in patients with solid tumors in China.
  • We identified all patients in Cancer Center of Sun Yat-sen University who were diagnosed as solid tumors (breast carcinoma, hepatocellular carcinoma, nasopharyngeal carcinoma, esophageal carcinoma, gastric cancer, cervical carcinoma, endometrial cancer, renal cell carcinoma, and non-small cell lung cancer) between January 2000 and August 2009.
  • All subjects were investigated regarding levels of white blood cells, platelets, and hemoglobin concentration.
  • The percentages of leukocytosis, anemia, and thrombocytosis in patients with solid tumors ranged from 4.0% to 25.6%, 3.3% to 29.2%, and 2.1% to 9.7%, respectively.
  • Leukocytosis was an independent prognostic factor in patients with cervical cancer (P = 0.007).
  • A pretreatment anemia or leukocytosis can serve as a useful marker to predict outcome of patients in some of the solid tumors.
  • [MeSH-major] Anemia / epidemiology. Breast Neoplasms / complications. Esophageal Neoplasms / complications. Leukocytosis / epidemiology. Liver Neoplasms / complications. Stomach Neoplasms / complications. Thrombocytosis / epidemiology


32. Tompkins C, Cheng A, Brinker JA, Marine JE, Nazarian S, Spragg DD, Sinha S, Halperin H, Tomaselli GF, Berger RD, Calkins H, Henrikson CA: Significance of leukocytosis after cardiac device implantation. Am J Cardiol; 2013 Jun 1;111(11):1608-12
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  • [Title] Significance of leukocytosis after cardiac device implantation.
  • Whether early postprocedural leukocytosis, a recognized marker of infection, is an indicator of impending infection is unclear and was the focus of this study.
  • The association between change in white blood cell (WBC) count and development of infection after device implantation was assessed.
  • Pre- and postprocedural WBC counts were obtained within 48 hours of the procedure.
  • Significant leukocytosis was defined as a ≥50% increase in WBC count; 1,245 device implantations met inclusion criteria.
  • A modest 17.6 ± 30.2% increase in WBC count was observed for the entire cohort.
  • Cases resulting in infection demonstrated minimal change in WBC count (mean +5.5 ± 26.5%).
  • No infections occurred in patients with ≥50% increases in WBC count or postprocedural WBC counts >15,000/μl.
  • Subjects with significant leukocytosis were younger (mean age 61.9 ± 16.5 vs 65.6 ± 15.1 years, p <0.01), had longer procedure times (mean 198 ± 97 vs 170 ± 77 minutes, p <0.001), and received biventricular implantable cardioverter-defibrillators (25% vs 13.9%, p <0.001).
  • In conclusion, after device implantation, a ≥50% increase in WBC count occurred in about 10% to 15% of patients.
  • Age, race, type of device, and procedure time influenced the development of significant leukocytosis.
  • Elevation in WBC count after cardiac device implantation was not associated with an increased risk for early infection.
  • [MeSH-major] Arrhythmias, Cardiac / therapy. Bacteremia / complications. Defibrillators, Implantable / adverse effects. Leukocytosis / etiology. Pacemaker, Artificial / adverse effects. Prosthesis-Related Infections / complications
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Incidence. Leukocyte Count. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. United States / epidemiology

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23523060.001).
  • [ISSN] 1879-1913
  • [Journal-full-title] The American journal of cardiology
  • [ISO-abbreviation] Am. J. Cardiol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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33. Mehtap O, Ateşoğlu EB, Tarkun P, Gönüllü E, Keski H, Topçu Y, Uzülmez N, Sünnetçi D, Hacıhanefioğlu A: The association between gene polymorphisms and leukocytosis with thrombotic complications in patients with essential thrombocythemia and polycythemia vera. Turk J Haematol; 2012 Jun;29(2):162-9
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  • [Title] The association between gene polymorphisms and leukocytosis with thrombotic complications in patients with essential thrombocythemia and polycythemia vera.
  • OBJECTIVE: Vascular events are a common complication in patients with polycythemia vera (PV) and essential thrombocythemia (ET).
  • This study aimed to analyze the association between PAI-1 4G/5G and ACE I/D gene polymorphisms, and leukocytosis with thrombosis in patients with PV and ET.
  • MATERIAL AND METHODS: In total, 64 patients with ET and PV were evaluated.
  • Vascular events were significantly more common in the patients with leukocytosis (leukocyte count >10 × 109 L-1) than in those without leukocytosis (leukocyte count ≤10 × 109 L-1) (P = 0.00).
  • CONCLUSION: PAI-1 and ACE gene polymorphisms were not considered new risk factors for thrombosis in PV and ET patients.
  • On the other hand, leukocytosis at diagnosis was associated with the occurrence of vascular events in the patients with ET and PV.

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  • (PMID = 24744648.001).
  • [ISSN] 1300-7777
  • [Journal-full-title] Turkish journal of haematology : official journal of Turkish Society of Haematology
  • [ISO-abbreviation] Turk J Haematol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC3986955
  • [Keywords] NOTNLM ; ACE I/D / Essential thrombocythemia / Leukocytosis / PAI-1 4G/5G / Polycythemia vera / Thrombosis
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34. Weber KS, Defosse JM, Wappler F, Sakka SG: [Case report. Leukocytosis in the course of Clostridium difficile infection]. Anasthesiol Intensivmed Notfallmed Schmerzther; 2013 Jun;48(6):386-90
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  • [Title] [Case report. Leukocytosis in the course of Clostridium difficile infection].
  • [Transliterated title] Kasuistik. Leukozytose im Zuge einer Clostridium-difficile-Infektion.
  • Leukocytosis is a sign of severe CDI and is predictive for a complicated course.
  • In this case report, we describe 2 patients with CDI who developed leukocytosis within a leukemoid range.
  • In both cases high white blood cell counts returned totally to normal range under CDI therapy according to guidelines.
  • Leukemia-related therapy patterns were not needed.
  • [MeSH-major] Clostridium difficile. Enterocolitis, Pseudomembranous / complications. Leukocytosis / etiology

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  • [Copyright] © Georg Thieme Verlag Stuttgart · New York.
  • (PMID = 23828079.001).
  • [ISSN] 1439-1074
  • [Journal-full-title] Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
  • [ISO-abbreviation] Anasthesiol Intensivmed Notfallmed Schmerzther
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 140QMO216E / Metronidazole
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35. Richards JR, Farias VF, Clingan CS: Association of leukocytosis with amphetamine and cocaine use. ScientificWorldJournal; 2014;2014:207651
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  • [Title] Association of leukocytosis with amphetamine and cocaine use.
  • OBJECTIVE: Determining the etiology of unexplained leukocytosis in asymptomatic patients may incur unnecessary testing, cost, and prolonged emergency department stay.
  • RESULTS: With a total of 1,206 patients, 877 (72.7%) amphetamines/cocaine-negative drug screen controls had mean WBC 8.4 ± 2.6 × 10³/µL.
  • The 240 (19.9%) amphetamines-positive, cocaine-negative, patients had WBC 9.4 ± 3.3 × 10³/µL (P < 0.0001).
  • The 72 (6.0%) amphetamines-negative, cocaine-positive, patients had WBC 7.1 ± 1.8 × 10³/µL (P < 0.0001).
  • The remaining 17 (1.4%) amphetamines/cocaine-positive patients had WBC 10.0 ± 4.2 × 10³/µL (P = 0.01).
  • Amphetamines-positive patients had a supranormal WBC ratio significantly higher than controls (23.8% versus 14.8%, P = 0.001), whereas only one cocaine-positive patient had a supranormal WBC count, with significantly lower ratio (1.4%, P = 0.0003).
  • CONCLUSION: Use of amphetamines, not cocaine, may be associated with idiopathic leukocytosis.
  • [MeSH-major] Amphetamine-Related Disorders / blood. Amphetamine-Related Disorders / complications. Cocaine-Related Disorders / blood. Cocaine-Related Disorders / complications. Leukocytosis / blood. Leukocytosis / etiology
  • [MeSH-minor] Adult. Female. Humans. Leukocyte Count. Male. Middle Aged. Retrospective Studies

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  • (PMID = 24578625.001).
  • [ISSN] 1537-744X
  • [Journal-full-title] TheScientificWorldJournal
  • [ISO-abbreviation] ScientificWorldJournal
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3919105
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36. Patel T, Wambi C, Berg WT, Bergman A, Shapiro EY, Badani KK: Characterization of perioperative leukocytosis in patients undergoing robot-assisted radical prostatectomy: effects of Gleason score and race. J Endourol; 2013 Dec;27(12):1463-7
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  • [Title] Characterization of perioperative leukocytosis in patients undergoing robot-assisted radical prostatectomy: effects of Gleason score and race.
  • INTRODUCTION: Our objective was to determine the impact of race and tumor grade on perioperative leukocytosis on patients undergoing robot-assisted radical prostatectomy (RARP).
  • White blood cell (WBC) counts were captured preoperatively, 1 hour postoperatively, and on postoperative day 1.
  • We assessed the differences in leukocyte responses according to the race and Gleason score using ANOVA testing.
  • RESULTS: Preoperative WBC was lowest in black men and comparable between white and Hispanic men.
  • At 1 hour, postoperative WBC remained lowest in Black men (p<0.001).
  • Post-RARP leukocytosis varied significantly depending on the race (p<0.001).
  • At 1 hour, patients with Gleason 8-10 tumors had decreased WBC compared to Gleason 6 patients (p<0.05) despite similar preoperative WBC and Charlson comorbidity index values.
  • [MeSH-major] Continental Population Groups. Leukocytosis / blood. Prostatectomy / methods. Prostatic Neoplasms / blood. Robotics
  • [MeSH-minor] Adult. Aged. Follow-Up Studies. Humans. Incidence. Leukocyte Count. Male. Middle Aged. Neoplasm Grading. Perioperative Period. Prognosis. Prostate-Specific Antigen / blood. Retrospective Studies. United States / epidemiology

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  • (PMID = 24074199.001).
  • [ISSN] 1557-900X
  • [Journal-full-title] Journal of endourology / Endourological Society
  • [ISO-abbreviation] J. Endourol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.4.21.77 / Prostate-Specific Antigen
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37. Sand KL, Flatebo T, Andersen MB, Maghazachi AA: Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males. World J Exp Med; 2013 Feb 20;3(1):11-20
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  • [Title] Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males.
  • Blood samples were collected before and after exercise.
  • RESULTS: We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation.
  • However, all cell types were increased in the circulation after 5 min intense exercise.
  • No differences in the pattern of cell increase were observed among the genders.
  • Activated partial thromboplastin time (APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood.
  • APTT is reduced and D-dimer values significantly increased after intense exercise.
  • CONCLUSION: Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders.
  • A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.

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  • (PMID = 24520541.001).
  • [ISSN] 2220-315X
  • [Journal-full-title] World journal of experimental medicine
  • [ISO-abbreviation] World J Exp Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3905589
  • [Keywords] NOTNLM ; Activated partial thromboplastin time / D-dimer / Exercise / Leukocytosis
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38. Chen Y, Zhang L, Liu WX, Liu XY: Prognostic significance of preoperative anemia, leukocytosis and thrombocytosis in chinese women with epithelial ovarian cancer. Asian Pac J Cancer Prev; 2015;16(3):933-9
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  • [Title] Prognostic significance of preoperative anemia, leukocytosis and thrombocytosis in chinese women with epithelial ovarian cancer.
  • Malignant tumors are often accompanied by increased risk of hematological abnormalities.
  • However, few studies have reported any prognostic impact of preoperative thrombocytosis, leukocytosis and anemia in epithelia ovarian cancer (EOC).
  • This study aimed to investigate preoperative hematological parameters for anemia, leukocytosis and thombocytosis in relation to established prognostic factors and survival in EOC cases.
  • A total of 816 Chinese women treated for EOC were retrospectively included in the study focusing on the relationship between preoperative hemoglobin, leukocyte and platelet counts, and a panel of clinicopathologic characteristics and outcome.
  • Preoperative anemia was present in 13.4%, leukocytosis in 16.7% and thrombocytosis in 22.8% .
  • Additionally, EOC patients with low differentiation grade, advanced stage, lymph node (LN) metastasis, residual disease ≥ 1cm, ascites volume >1,000ml, serum cancer antigen 125 (CA125) >675U/ml, and disease recurrence had the higher prevalence of preoperative anemia, leukocytosis and thrombocytosis (all p<0.05).
  • Conclusively, preoperative anemia, leukocytosis or thrombocytosis in EOC patients is closely associated with more malignant disease phenotype and poorer prognosis.
  • Significantly, thrombocytosis may independently predict the disease- specific survival for EOC patients.

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  • (PMID = 25735385.001).
  • [ISSN] 1513-7368
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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39. Chou YS, Gau JP, Yu YB, Pai JT, Hsiao LT, Liu JH, Hong YC, Liu CY, Yang CF, Chen PM, Chiou TJ, Tzeng CH: Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage. Eur J Haematol; 2013 Mar;90(3):228-36
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  • [Title] Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage.
  • BACKGROUND: Long-term outcomes are favorable for patients with polycythemia vera (PV) and for patients with essential thrombocythemia (ET).
  • METHODS: We retrospectively recruited 247 patients who had received a diagnosis of PV (n = 101) or ET (n = 146) during the period 2001-2010.
  • RESULTS: After a median follow-up period of 36.2 months, the cumulative incidence of hemorrhage was 39.6% in patients with PV (6.2% per person-year) and 29.7% in patients with ET (5.9% person-years).
  • Episodes of major bleeding occurred in 9.9% of patients with PV and in 14.4% of patients with ET.
  • Overall survival was significantly shorter among patients with hemorrhage than among those without said complication (P < 0.001 for overall patients; P = 0.002 for patients with PV; P = 0.026 for patients with ET).
  • In the univariate analysis, age ≥ 60 yr (OR: 4.77, P = 0.046) and WBC ≥ 16 × 10(9) /L (OR: 4.15, P = 0.010) were predictors of hemorrhage in patients with PV, and age ≥ 60 yr (OR: 3.25, P = 0.040), WBC ≥ 16 × 10(9) /L (OR: 2.89, P = 0.024), albumin <4.0 g/dL (OR: 4.10, P = 0.002), and splenomegaly (OR: 5.19, P = 0.002) were predictors of hemorrhage in patients with ET.
  • Multivariate analysis showed that WBC ≥ 16 × 10(9) /L was the only significant risk factor for hemorrhage in patients with PV (OR: 3.51, P = 0.026) and that splenomegaly was the only risk factor for hemorrhage in patients with ET (OR: 3.00, P = 0.048).
  • CONCLUSION: Leukocytosis in PV and splenomegaly in ET are independent risk factors for hemorrhage.
  • [MeSH-major] Hemorrhage / complications. Leukocytosis / complications. Polycythemia Vera / complications. Splenomegaly / complications. Thrombocythemia, Essential / complications
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Leukocyte Count. Leukocytes / pathology. Male. Middle Aged. Retrospective Studies. Risk Factors. Survival Rate


40. Asadollahi K, Beeching NJ, Gill GV: Leukocytosis as a predictor for non-infective mortality and morbidity. QJM; 2010 May;103(5):285-92
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  • [Title] Leukocytosis as a predictor for non-infective mortality and morbidity.
  • Leukocytosis (raised concentration of white cells in the blood) is commonly associated with infection or inflammation, but can occur in a wide variety of other conditions.
  • Leukocytosis has also been linked with increased mortality and morbidity in a number of studies.
  • We have systematically reviewed the relevant literature, which clearly demonstrates an association between leukocytosis and mortality-particularly due to cardiovascular or cerebrovascular causes.
  • The mechanisms of this effect are uncertain but, when combined with other markers predictive of death, leukocytosis may contribute to modelling systems to predict in-patient mortality risk.
  • [MeSH-major] Cardiovascular Diseases / mortality. Leukocytosis / mortality

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  • (PMID = 20056764.001).
  • [ISSN] 1460-2393
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 46
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41. Díaz-Rosales Jde D, Enríquez-Domínguez L, Castillo-Moreno JR, Herrera-Ramírez F: [Preoperative leukocytosis as a predictor of intrabdominal injury in penetrating abdominal trauma]. Cir Cir; 2012 Nov-Dec;80(6):516-22
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  • [Title] [Preoperative leukocytosis as a predictor of intrabdominal injury in penetrating abdominal trauma].
  • [Transliterated title] Leucocitosis prequirúrgica como factor predictivo de lesión a órgano intrabdominal en trauma penetrante abdominal.
  • Is possible use some grade of leukocytosis suspect in-trabdominal lesion?
  • Dependent variables were; age, gender, type of injury, number of lesions, peripheral lesions, time between injury and, from a laboaratory blood sample, leukocytosis mean, percentage of neutrophils, leukocytosis ≥ 12,500 /mm(3), and hemoperitoneum.
  • Leukocytosis global was 13.2 mil/mm(3) and neutrophil range of 70.3%.
  • 26% of patients did not have leukocytosis at arrival and evaluation, however they were laparotomized because of present peritoneal irritation.
  • Leukocytosis ≥ 12.5 mil/mm(3) was statistically significant in patients with intrabdominal lesions (74.2% vs 27.7%, p < 0.001).
  • CONCLUSIONS: leukocytosis ≥ 12.5 mil/mm(3) could be an early serum marker abdominal penetrating trauma.
  • [MeSH-major] Abdominal Injuries / blood. Leukocytosis / etiology. Peritoneum / injuries. Preoperative Care. Viscera / injuries. Wounds, Penetrating / blood
  • [MeSH-minor] Adolescent. Adult. Female. Hemoperitoneum / epidemiology. Hemoperitoneum / etiology. Humans. Laparotomy / methods. Laparotomy / utilization. Length of Stay / statistics & numerical data. Leukocyte Count. Male. Mexico / epidemiology. Middle Aged. Predictive Value of Tests. Retrospective Studies. Trauma Centers / statistics & numerical data. Triage. Wounds, Gunshot / blood. Wounds, Gunshot / diagnosis. Wounds, Gunshot / epidemiology. Wounds, Gunshot / surgery. Wounds, Stab / blood. Wounds, Stab / diagnosis. Wounds, Stab / epidemiology. Wounds, Stab / surgery. Young Adult

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  • (PMID = 23336145.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Mexico
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42. Ota S, Hiramatsu Y, Kondo E, Kasahara A, Takada S, Umena S, Noguchi T, Tanimoto M, Matsumura T: Severe case of peripheral leukocytosis initially diagnosed as myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, but possibly prefibrotic primary myelofibrosis. Acta Med Okayama; 2014 Dec;68(6):363-8
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  • [Title] Severe case of peripheral leukocytosis initially diagnosed as myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, but possibly prefibrotic primary myelofibrosis.
  • Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).
  • A 74-year-old woman was admitted to our hospital for tarry stools, anemia, and marked peripheral leukocytosis of 1.4×10(5)/μL.
  • A fluorescence in situ hybridization test could not detect the BCR-ABL fusion gene.
  • However, the megakaryocytic abnormality was not strictly compatible with the criteria.
  • Instead, we considered prefibrotic primary myelofibrosis as a possibility, although myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) was technically the correct diagnosis.
  • The present case shows that MPN diagnosis remains difficult and suggests that other cases of peripheral leukocytosis with diagnosed MDS/MPN-U might include similar findings.

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  • (PMID = 25519030.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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43. Hurtado-Cordovi J, Pathak P, Avezbakiyev B, Frieri M: Inflammatory malignant fibrous histiocytoma associated with leukemoid reaction or leukocytosis: a comprehensive review. ISRN Oncol; 2012;2012:946019
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  • [Title] Inflammatory malignant fibrous histiocytoma associated with leukemoid reaction or leukocytosis: a comprehensive review.
  • Inflammatory malignant fibrous histiocytoma (IMFH) associated with leukemoid reaction (LR)/leukocytosis is a rare entity.
  • In this paper, we search PubMed for all known cases of IMFH associated with LR/leukocytosis in an attempt to draw conclusions about this variant's response to treatments and its pathophysiology.
  • Medline electronic database was searched using key words such as malignant fibrous histiocytoma, leukemoid reaction, and leukocytosis.
  • Of the 12 patients that expired, death occurred approximately 92 days after the onset of LR or leukocytosis, ranging from 3 to 334 days.
  • We conclude that IMFH associated with LR/leukocytosis does not completely respond to chemoradiation.
  • Overproduction of growth factors and cytokines by IMFH cells and their interactions with the inflammatory infiltrate seem to promote immunological effector cell's dysfunction and substantiate the development and growth of this neoplasm.

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  • (PMID = 23097722.001).
  • [ISSN] 2090-567X
  • [Journal-full-title] ISRN oncology
  • [ISO-abbreviation] ISRN Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC3477745
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44. Deirmengian GK, Zmistowski B, Jacovides C, O'Neil J, Parvizi J: Leukocytosis is common after total hip and knee arthroplasty. Clin Orthop Relat Res; 2011 Nov;469(11):3031-6
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  • [Title] Leukocytosis is common after total hip and knee arthroplasty.
  • Although leukocytosis may be a sign of a developing infection in the early postoperative period, it may also be part of a normal surgical response.
  • QUESTIONS AND PURPOSES: We determined (1) the natural history of white blood cell values after primary THA and TKA, (2) factors associated with early postoperative leukocytosis, and (3) the predictive value of white blood cell count for early postoperative periprosthetic joint infection.
  • We determined the incidence of leukocytosis and characterized the natural history of postoperative white blood cell counts.
  • We then investigated potential indicators of postoperative leukocytosis, including development of early periprosthetic infection.
  • RESULTS: The average postoperative white blood cell count increased to approximately 3 × 10(6) cells/μL over the first 2 postoperative days and then declined to a level slightly higher than the preoperative level by Postoperative Day 4.
  • The incidence of postoperative leukocytosis for all patients was 38%.
  • Factors associated with postoperative leukocytosis included TKA, bilateral procedures, older age, and higher modified Charlson Comorbidity Index.
  • The sensitivity and specificity of white blood cell count for diagnosing early periprosthetic infection were 79% and 46%, respectively.
  • CONCLUSIONS: Postoperative leukocytosis is common after THA and TKA and represents a normal physiologic response to surgery.
  • In the absence of abnormal clinical signs and symptoms, postoperative leukocytosis may not warrant further workup for infection.
  • [MeSH-major] Arthroplasty, Replacement, Hip / adverse effects. Arthroplasty, Replacement, Knee / adverse effects. Leukocytosis / diagnosis. Prosthesis-Related Infections / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Comorbidity. Databases, Factual. Female. Humans. Leukocyte Count. Male. Middle Aged. Pennsylvania / epidemiology. Postoperative Complications. Predictive Value of Tests. Young Adult

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  • (PMID = 21461866.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3183208
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45. Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T: Ultrasonography for leukocytosis or elevated C-reactive protein. Hepatogastroenterology; 2011 Jul-Aug;58(109):1156-8
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  • [Title] Ultrasonography for leukocytosis or elevated C-reactive protein.
  • BACKGROUND/AIMS: Patients with abdominal symptoms and leukocytosis or elevated C-reactive protein were subjected to abdominal ultrasonography (US) for correct diagnosis.
  • METHODOLOGY: Patients with abdominal symptoms, leukocytosis and elevated C-reactive protein were enrolled.
  • Those with abnormal liver enzymes or radiographs were excluded since either of them might be a clue to proper diagnosis, such as hepatobiliary diseases or bowel obstruction.
  • RESULTS: Total number of patients was 38.
  • Number of acute diverticulitis, colitis, acute appendicitis and enteritis were 8, 7, 7 and 6, respectively.
  • Colon cancers were confirmed and pelvis tumor was diagnosed as ovarian squamous cell carcinoma with surgical specimens.
  • CONCLUSIONS: Our data clearly recommended that abdominal US be performed carefully for patients with abdominal symptoms and leukocytosis or elevated CRP since potentially they had malignancies.
  • [MeSH-major] Abdomen / ultrasonography. C-Reactive Protein / analysis. Leukocytosis / ultrasonography

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  • (PMID = 21937369.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
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46. Banerjee R, Roxin G, Eliasziw M, Joseph K, Maclean A, Buie WD, Doll C: The prognostic significance of pretreatment leukocytosis in patients with anal cancer treated with radical chemoradiotherapy or radiotherapy. Dis Colon Rectum; 2013 Sep;56(9):1036-42
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  • [Title] The prognostic significance of pretreatment leukocytosis in patients with anal cancer treated with radical chemoradiotherapy or radiotherapy.
  • BACKGROUND: There are emerging data showing the prognostic significance of pretreatment leukocytosis in patients with cervical cancer; it is generally associated with adverse outcome.
  • However, the prognostic impact of leukocytosis in patients with anal cancer has not been previously reported.
  • OBJECTIVE: The purpose of this study was to assess the relationship between pretreatment leukocytosis and clinical outcomes in patients with anal cancer treated with radical chemoradiotherapy or radiotherapy.
  • MAIN OUTCOME MEASURES: The primary outcomes were disease-free and overall survival.
  • Pretreatment leukocytosis (white blood cell count >10 × 10/L) was identified in 15.9% (20/126) of patients.
  • After adjusting for sex, tumor size, and stage in a multivariate analysis, leukocytosis remained significantly associated with worse disease-free survival (HR, 2.2; 95% CI, 1.1-4.8; p = 0.045) and worse overall survival (HR, 2.9; 95% CI, 1.1-7.9; p = 0.036).
  • Patients with both leukocytosis and anemia (pretreatment hemoglobin <125 g/L) had the worst prognosis: 2-year disease-free survival 42.1% versus 72.9% for patients without these factors (HR, 2.7; 95% CI, 1.1-6.8; p = 0.033); 2-year overall survival 60.9% versus 89.8% (HR, 4.5; 95% CI, 1.5-13.2; p = 0.006).
  • LIMITATIONS: The study was limited by its retrospective nature and lack of patients with multiple hematologic abnormalities (ie, both anemia and leukocytosis).
  • CONCLUSIONS: Pretreatment leukocytosis in patients with anal cancer is associated with significantly worse disease-free and overall survival, which appears to be exacerbated with the presence of pretreatment anemia.
  • [MeSH-major] Anus Neoplasms / therapy. Carcinoma, Adenosquamous / therapy. Carcinoma, Squamous Cell / therapy. Chemoradiotherapy. Leukocytosis / diagnosis

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  • (PMID = 23929012.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Multicenter Study
  • [Publication-country] United States
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47. Nikanfar M, Shaafi S, Hashemilar M, Oskouii DS, Goldust M: Evaluating role of leukocytosis and high sedimentation rate as prognostic factors in acute ischemic cerebral strokes. Pak J Biol Sci; 2012 Apr 15;15(8):386-90
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  • [Title] Evaluating role of leukocytosis and high sedimentation rate as prognostic factors in acute ischemic cerebral strokes.
  • Leukocytosis and increased Erythrocyte Sedimentation Rate (ESR) during the early phases of acute ischemic stroke has been proposed to be related with poor prognosis.
  • The White Blood Cell (WBC) count and ESR were determined on admitting and after 3 days.
  • Any history of Diabetes Mellitus (DM), Hypertension (HTN), Heart Disease (HD), Hyperlipidemia (HLP), smoking, CT scan findings, level of consciousness and the condition of patient on admission and discharge (according to Rankin's scale) were assessed.
  • Leukocytosis on day one was significantly more prevalent in patients passed away during hospitalization or discharged in not-so-well condition.
  • High WBC and ESR levels, altered consciousness, diffused lesions in CT scan and imperfect neurological condition on day one, as well as positive history of DM and HTN were significantly related with higher in-hospital death rate and/or poor condition at discharge.
  • Raised WBC count and ESR just after an ischemic stroke attack might be related with a poor prognosis and necessitate immediate and meticulous monitoring and therapies.
  • [MeSH-major] Brain Ischemia / physiopathology. Leukocytosis / physiopathology. Stroke / physiopathology

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  • (PMID = 24199468.001).
  • [ISSN] 1028-8880
  • [Journal-full-title] Pakistan journal of biological sciences : PJBS
  • [ISO-abbreviation] Pak. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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48. Paladino L, Subramanian RA, Bonilla E, Sinert RH: Leukocytosis as prognostic indicator of major injury. West J Emerg Med; 2010 Dec;11(5):450-5
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  • [Title] Leukocytosis as prognostic indicator of major injury.
  • OBJECTIVE: To test the diagnostic use of the triage white blood cell (WBC) count in differentiating major from minor injuries.
  • We recorded age, sex, injury mechanism, vital signs, WBC, base deficit (BD), lactate (LAC) and calculated injury severity scores (ISS).
  • Major injury was defined as either a change in hematocrit >10 points or blood transfused within 24 hours, or ISS >15.
  • For vital signs, blood pressure was not significantly different between major and minor injury patients.
  • Major compared to minor injury patients had a statistically but not clinically significant higher heart rate.
  • Major injury patients had significantly (p < 0.0001) higher WBC count (10.53 K/μl, 95% CI: 9.7-11.3) compared to patients with minor injuries (8.92 K/μl, 95% CI: 8.7-9.2), but both were in the normal range.
  • Areas under the curve for WBC count (0.60, 95% CI: 0.54-0.66) are similar to BD (0.69, 95% CI: 0.63-0.74) and LAC (0.66, 95% CI: 0.60-0.71).
  • CONCLUSION: WBC count is not a useful addition as a diagnostic indicator of major trauma in our study population.

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  • (PMID = 21293764.001).
  • [ISSN] 1936-9018
  • [Journal-full-title] The western journal of emergency medicine
  • [ISO-abbreviation] West J Emerg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3027437
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49. Tossige-Gomes R, Ottone VO, Oliveira PN, Viana DJ, Araújo TL, Gripp FJ, Rocha-Vieira E: Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race. Braz J Med Biol Res; 2014 Jun;47(6):492-8
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  • [Title] Leukocytosis, muscle damage and increased lymphocyte proliferative response after an adventure sprint race.
  • The effect of an adventure sprint race (ASR) on T-cell proliferation, leukocyte count and muscle damage was evaluated.
  • The race induced a strong leukocytosis (6.22±2.04×10(3) cells/mm3 before vs 14.81±3.53×10(3) cells/mm3 after the race), marked by a significant increase of neutrophils and monocytes (P<0.05), but not total lymphocytes, CD3+ CD4+ or CD3+ CD8+ cells.
  • However, the T-cell proliferative response to mitogenic stimulation was increased (P=0.025) after the race, which contradicted our hypothesis that ASR, as a high-demand competition, would inhibit T-cell proliferation.
  • Muscle damage was evident after the race by increased serum levels of aspartate amino transferase (24.99±8.30 vs 50.61±15.76 U/L, P=0.003).
  • [MeSH-major] Cell Proliferation / physiology. Leukocytosis / immunology. Muscle, Skeletal / injuries. Physical Endurance / immunology. Running / injuries. T-Lymphocytes / immunology
  • [MeSH-minor] Adult. Alanine Transaminase / blood. Aspartate Aminotransferases / blood. Flow Cytometry. Humans. Immunosuppression. Leukocyte Count. Male. Monocytes / immunology. Neutrophils / immunology. T-Lymphocytes, Cytotoxic / physiology. T-Lymphocytes, Helper-Inducer / physiology. Time Factors

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  • (PMID = 24676476.001).
  • [ISSN] 1414-431X
  • [Journal-full-title] Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]
  • [ISO-abbreviation] Braz. J. Med. Biol. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] EC 2.6.1.1 / Aspartate Aminotransferases; EC 2.6.1.2 / Alanine Transaminase
  • [Other-IDs] NLM/ PMC4086176
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50. Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD: Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis. J Biol Chem; 2014 May 16;289(20):14045-55
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  • [Title] Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis.
  • Here we report that inactivation of Chop in mice fed a high fat diet led to significant increase in obesity caused by a reduction in energy expenditure without any change in food intake.
  • Importantly, ablation of Chop does not induce metabolically healthy obesity, because Chop-deficient mice fed a high fat diet had increased hepatic steatosis with significantly higher insulin resistance.
  • Quantification of adipose tissue leukocytosis revealed that elimination of Chop during obesity led to substantial increase in number of adipose tissue T and B lymphocytes.
  • In addition, deficiency of Chop led to increase in total number of myeloid subpopulations like neutrophils and F4/80(+) adipose tissue macrophages without any alterations in the frequency of M1- or M2-like adipose tissue macrophages.
  • [MeSH-major] Adipose Tissue / immunology. Leukocytosis / immunology. Leukocytosis / metabolism. Obesity / immunology. Obesity / metabolism. Transcription Factor CHOP / metabolism

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  • [Copyright] © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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  • (PMID = 24662293.001).
  • [ISSN] 1083-351X
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / AG043608; United States / NIA NIH HHS / AG / AG31797; United States / NIAID NIH HHS / AI / AI105097; United States / NIDDK NIH HHS / DK / DK064584-10; United States / NIDDK NIH HHS / DK / DK090556; United States / NIA NIH HHS / AG / R01 AG043608
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Inflammasomes; 147336-12-7 / Transcription Factor CHOP
  • [Other-IDs] NLM/ PMC4022874 [Available on 05/16/15]
  • [Keywords] NOTNLM ; Adipose Tissue Metabolism / Cell Metabolism / Energy Metabolism / Immunology / Inflammation / Insulin Resistance
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