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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||||||. 100%  Blyton F, Chuter V, Burns J: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness. J Foot Ankle Res; 2012;5:7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • BACKGROUND: Night-time calf cramping affects approximately 1 in 3 adults.
  • The aim of this study was to explore the experience of night-time calf cramp; if and where people seek treatment advice; and perceived treatment effectiveness.
  • METHODS: 80 adults who experienced night-time calf cramp at least once per week were recruited from the Hunter region, NSW, Australia through newspaper, radio and television advertisements.
  • All participants completed a pilot-tested survey about muscle cramp.
  • RESULTS: Median recalled age of first night-time calf cramp was 50 years.
  • Most participants recalled being awoken from sleep by cramping, and experiencing cramping of either calf muscle, calf-muscle soreness in the days following cramp and cramping during day-time.
  • Participants described their cramps as being 'unbearable', 'unmanageable' and 'cruel'.
  • One participant stated that 'sometimes I just wish I could cut my legs open' and another reported 'getting about 2 h sleep a night due to cramps'.
  • Most participants had sought advice about their night-time calf cramps from a health professional.
  • Participants identified 49 different interventions used to prevent night-time calf cramp.
  • Of all treatment ratings, 68% described the intervention used to prevent cramp as being 'useless' or of 'a little help'.
  • Of 14 participants who provided additional information regarding their use of quinine, eight had a current prescription of quinine for muscle cramp at the time of the survey.
  • CONCLUSION: Night time calf cramps typically woke sufferers from sleep, affected either leg and caused ongoing pain.
  • Most participants experienced little or no relief with current therapies used to prevent muscle cramp.
  • Most people who were taking quinine for muscle cramp were unaware that the Australian Therapeutic Goods Administration withdrew support of quinine for muscle cramp in 2004 due to the risk of thrombocytopaenia.
  • Case-control studies are required to identify therapeutic targets so that clinical trials can evaluate safe interventions to prevent recurrent cramp.

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  • (PMID = 22420923.001).
  • [ISSN] 1757-1146
  • [Journal-full-title] Journal of foot and ankle research
  • [ISO-abbreviation] J Foot Ankle Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3361473
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2. |||||||||. 89%  Blyton F, Ryan MM, Ouvrier RA, Burns J: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors. Neurology; 2011 Dec 13;77(24):2115-8
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  • [Title] Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • OBJECTIVES: To identify correlates of calf cramp in children with Charcot-Marie-Tooth disease type 1A (CMT1A).
  • Post hoc logistic regression analyses were performed to identify independent predictors of calf cramp.
  • RESULTS: Of the 81 children, 26 (32%) reported calf cramp, and 1 child each reported toe, quadriceps, or arm cramp.
  • Calf cramp was associated (p < 0.05) with older age; the presence of hand tremor; stronger foot inversion, eversion, dorsiflexion, and plantarflexion; and better performance in long-jump and 9-hole peg tests.
  • Logistic regression analysis revealed only increasing age (odds ratio [OR] 1.32, 95% confidence interval [CI] 1.11-1.58; p = 0.002) and the presence of hand tremor (OR 3.81, 95% CI 1.18-12.56; p = 0.028) as independent predictors of calf cramp.
  • CONCLUSION: Calf cramps are common in children with CMT1A and worsen with age.
  • This study revealed a previously unrecognized link between cramp and hand tremor in children with CMT1A.
  • Further investigation of proposed mechanisms and risk factors common to both cramp and tremor will contribute to our understanding of these common complications of CMT1A.
  • [MeSH-major] Charcot-Marie-Tooth Disease / complications. Muscle Cramp / complications


3. |......... 11%  Senapin S, Phiwsaiya K, Gangnonngiw W, Flegel TW: False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia. J Negat Results Biomed; 2011;10:10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia.
  • BACKGROUND: Infectious myonecrosis virus (IMNV) disease outbreaks in cultivated whiteleg shrimp Penaeus (Litopenaeus) vannamei are characterized by gross signs of whitened abdominal muscles and by slow mortality reaching up to 70%.
  • In 2006 the first disease outbreaks caused by IMNV in Asia occurred in Indonesia.
  • Since then rumours have periodically circulated about IMNV disease outbreaks in other Asian countries.
  • In most cases, our shrimp samples for which tissue sections were possible showed signs of muscle cramp syndrome that also commonly causes muscle whitening in stressed whiteleg shrimp.
  • Thus, we suspect that most of the false rumours in Asia about IMNV outside of Indonesia have resulted because of muscle cramp syndrome.
  • We suspect that confusion has arisen because muscle cramp syndrome causes similar signs of whitened tail muscles in whiteleg shrimp.

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  • [Cites] Dis Aquat Organ. 2005 Feb 28;63(2-3):261-5 [15819442.001]
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  • [Cites] J Gen Virol. 2006 Apr;87(Pt 4):987-96 [16528049.001]
  • (PMID = 21813002.001).
  • [ISSN] 1477-5751
  • [Journal-full-title] Journal of negative results in biomedicine
  • [ISO-abbreviation] J Negat Results Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC3199911
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4. |......... 7%  Cooper IF, Siadaty MS: 'Intellectual Products' associated with 'Cramp Finding': Top Publications. BioMedLib Review; IntellectualProduct;CrampFinding:706134989. ISSN: 2331-5717. 2014/1/23
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  • [Title] 'Intellectual Products' associated with 'Cramp Finding': Top Publications.
  • There are articles published each month which present 'Intellectual Product' for 'cramp finding'.
  • Bilbey DL et al: Muscle cramps and magnesium deficiency: case reports.
  • Chiba S et al: Autosomal dominant muscle cramp syndrome in a Japanese family.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Demircan MN et al: Cramp finding: can it be used as a new diagnostic and prognostic factor in lumbar disc surgery?.
  • Cooper IF et al: 'Steroids' associated with 'Cramps Of Lower Extremities': Top Publications.
  • Van den Bergh P et al: Familial muscle cramps with autosomal dominant transmission.
  • Sebo P et al: Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Mohan P et al: Medical image. Recurrent muscle cramps in chronic diarrhoea. Primary intestinal lymphangiectasia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706134989.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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5. |......... 6%  Ge HY, Fernández-de-Las-Peñas C, Yue SW: Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation. Chin Med; 2011;6:13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity.
  • Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps.

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  • (PMID = 21439050.001).
  • [ISSN] 1749-8546
  • [Journal-full-title] Chinese medicine
  • [ISO-abbreviation] Chin Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3070691
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6. |......... 5%  Cooper IF, Siadaty MS: 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications. BioMedLib Review; NaturalPhenomenonOr;CrampFinding:706151289. ISSN: 2331-5717. 2014/11/23
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  • [Title] 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications.
  • There are articles published each month which present 'Natural Phenomenon or Process' for 'cramp finding'.
  • Miller KC et al: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • Serrao M et al: Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps.
  • Merletti R et al: Spinal involvement and muscle cramps in electrically elicited muscle contractions.
  • Miller KC et al: Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Nilsson SE: [Electromagnetic therapy in restless legs syndrome and nocturnal leg muscle cramps. Same effect of pulsating electromagnetic fields and placebo].
  • Miller KC et al: Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • TILLE D: [Initial fever cramps and the weather].
  • Minetto MA et al: Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706151289.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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7. |||||||||. 129%  Drouet A: [Management of muscle cramp: what's to be done?]. Rev Prat; 2013 May;63(5):619-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of muscle cramp: what's to be done?].
  • [Transliterated title] Comment optimiser la prise en charge des crampes musculaires?
  • Muscle cramp is characterized by involuntary, painful, visible contraction of a muscle (or a part of muscle) and is always associated with irregular repetitive firing of motor unit action potentials (200 à 300 Hz) which is caused by hyperexcitability of intramuscular terminal motor axons.
  • A careful history and examination should allow the physician to determine the significance of cramp.
  • ENMG and biological tests are needed in cases of severe symptoms (severity and frequency of cramps) and/or abnormal examination.
  • Idiopathic and secondary (drug or metabolic disorders) cramps are the most common groups, but it's very important to search the motor unit diseases (neuropathy, radiculopathy, plexopathy, neuromyotonia, and a cramp fasciculation syndrome which can preceded ALS).
  • The first goal in management of cramp is to determine if there is an underlying cause and the second to use physical measures (stretching), because, pharmacologic treatments have a moderate interest because of the potential of toxicity (quinine sulfate) or a little effectiveness (vitamin B complex, naftidrofuryl, and calcium channel blockers such as diltiazem, gabapentin).
  • Isolated cramp doesn't need treatment.
  • [MeSH-major] Muscle Cramp / therapy

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  • (PMID = 23789484.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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8. |||||||||. 128%  Okada Y, Ayaki T, Matsumoto R, Ito H, Takahashi R, Nakano S: [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement]. Rinsho Shinkeigaku; 2012;52(10):774-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement].
  • A 53-year-old man presented mild, but gradually worsening, distal-dominant upper bilateral limbs weakness and muscle cramp in both legs from the age of 30.
  • He had no obvious muscle atrophy during the course of the disease.
  • Muscle biopsy of the right lateral vastus muscle showed myopathic changes with round or helical hyaline inclusions in eosinophilic on H&E staining and dark green on modified Gomori trichrome.
  • While MFM patients are sometimes reported to develop serious conditions such as severe weakness, cardiomyopathy or respiratory failure, which require a pacemaker or mechanical ventilator, our case only had mild distal dominant limb weakness and muscle cramps.
  • [MeSH-major] Arrhythmogenic Right Ventricular Dysplasia / complications. Arrhythmogenic Right Ventricular Dysplasia / diagnosis. Muscle Cramp / etiology. Muscle, Skeletal. Muscular Atrophy / etiology
  • [MeSH-minor] Connectin / metabolism. Desmin / metabolism. Diagnosis, Differential. Disease Progression. Extremities. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 23064629.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Connectin; 0 / Desmin; 0 / MYOT protein, human; Arrhythmogenic Right Ventricular Dysplasia, Familial, 7
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9. |||||||||. 87%  Miller KC, Knight KL, Wilding SR, Stone MB: Duration of electrically induced muscle cramp increased by increasing stimulation frequency. J Sport Rehabil; 2012 May;21(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • CONTEXT: Electrically induced muscle cramps (EIMC) do not last long enough to study many cramp treatments.
  • Increasing stimulation frequency lengthens cramp duration; it is unknown which frequency elicits the longest EIMC.
  • OBJECTIVE: To determine which stimulation frequency elicits the longest EIMC and whether cramp duration and stimulation frequency are correlated.
  • PARTICIPANTS: 20 participants (12 male, 8 female; age 20.7 ± 0.6 y; height 174.9 ± 1.9 cm; mass 76.6 ± 2.2 kg) with a self-reported history of muscle cramps in their lower extremities within the 6 mo before the study.
  • After 1 min of rest, stimulation frequency increased in 2-Hz increments until a cramp occurred in the flexor hallucis brevis.
  • The stimulation frequency at which a cramp occurred was termed cramp threshold frequency (TF).
  • Cramp duration was determined using strict clinical criteria (loss of hallux rigidity and return of hallux neutral).
  • On the next 4 consecutive days, participants were stimulated at 5, 10, 15, or 20 Hz above TF, and cramp duration was reassessed.
  • MAIN OUTCOME MEASURES: Cramp TF and duration.
  • RESULTS: Cramp TF was 16.9 ± 5.1 Hz.
  • Cramp duration was longer at 15 and 20 Hz above TF (77.9 ± 37.6 s and 69.5 ± 36.9 s, respectively) than at TF (40.8 ± 34.0 s; P < .05).
  • Cramp duration and TF were highly correlated (r = .90).
  • CONCLUSIONS: Stimulating at 15 and 20 Hz above cramp TF produces the longest-lasting EIMC.

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  • (PMID = 22104040.001).
  • [ISSN] 1543-3072
  • [Journal-full-title] Journal of sport rehabilitation
  • [ISO-abbreviation] J Sport Rehabil
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. ||||||||.. 81%  Braulick KW, Miller KC, Albrecht JM, Tucker JM, Deal JE: Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency. Br J Sports Med; 2013 Jul;47(11):710-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency.
  • OBJECTIVE: Many clinicians believe that exercise-associated muscle cramps (EAMC) occur because of dehydration.
  • Mild hypohydration (3% body mass loss) does not alter threshold frequency (TF), a measure of cramp susceptibility, when fatigue and exercise intensity are controlled.
  • Dominant limb flexor hallucis brevis cramp TF, cramp electromyography (EMG) amplitude and cramp intensity were measured in 10 euhydrated, unacclimated men (age=24±4 years, height=184.2±4.8 cm, mass=84.8±11.4 kg).
  • Cramp variables were reassessed posthypohydration.
  • They lost 4.7±0.5% of their body mass (3.9±0.5 litres of fluid), 4.0±1.5 g of Na(+) and 0.6±0.1 g K(+) via exercise-induced sweating.
  • Significant (n=5) or serious hypohydration (n=5) did not alter cramp TF (euhydrated=15±5 Hz, hypohydrated=13±6 Hz; F1,9=3.0, p=0.12), cramp intensity (euhydrated= 94.2±41%, hypohydrated=115.9±73%; F1,9=1.9, p=0.2) or cramp EMG amplitude (euhydrated=0.18±0.06 µV, hypohydrated= 0.18±0.09 µV; F1,9=0.1, p=0.79).
  • CONCLUSIONS: Significant and serious hypohydration with moderate electrolyte losses does not alter cramp susceptibility when fatigue and exercise intensity are controlled.
  • Neuromuscular control may be more important in the onset of muscle cramps than dehydration or electrolyte losses.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Biological Markers / blood. Electromyography. Exercise / physiology. Humans. Male. Muscle Fatigue / physiology. Muscle, Skeletal / physiology. Sweat / chemistry. Young Adult

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  • (PMID = 23222192.001).
  • [ISSN] 1473-0480
  • [Journal-full-title] British journal of sports medicine
  • [ISO-abbreviation] Br J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biological Markers
  • [Keywords] NOTNLM ; Dehydration / Muscle cramping
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11. ||||||.... 59%  Bischoff M: [From muscle cramp to rhabdomyolysis: what is causing muscle pain?]. MMW Fortschr Med; 2012 Oct 4;154(17):26-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [From muscle cramp to rhabdomyolysis: what is causing muscle pain?].
  • [MeSH-major] Muscle Cramp / etiology. Pain / etiology. Rhabdomyolysis / etiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Medical History Taking. Muscle Weakness / etiology. Physical Examination


12. |......... 10%  Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans. Med Sci Sports Exerc; 2010 May;42(5):953-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • INTRODUCTION: Anecdotal evidence suggests that ingesting small volumes of pickle juice relieves muscle cramps within 35 s of ingestion.
  • No experimental evidence exists supporting the ingestion of pickle juice as a treatment for skeletal muscle cramps.
  • METHODS: On two different days (1 wk apart), muscle cramps were induced in the flexor hallucis brevis (FHB) of hypohydrated male subjects (approximately 3% body weight loss and plasma osmolality approximately 295 mOsm x kg(-1) H2O) via percutaneous tibial nerve stimulation.
  • Thirty minutes later, a second FHB muscle cramp was induced and was followed immediately by the ingestion of 1 mL x kg(-1) body weight of deionized water or pickle juice (73.9 +/- 2.8 mL).
  • RESULTS: Cramp duration and FHB EMG activity during the cramp were quantified, as well as the change in plasma constituents.
  • Cramp duration (water = 151.9 +/- 12.9 s and pickle juice = 153.2 +/- 23.7 s) and FHB EMG activity (water = 60% +/- 6% and pickle juice = 68% +/- 9% of maximum voluntary isometric contraction EMG activity) were similar during the initial cramp induction without fluid ingestion (P > 0.05).
  • During FHB muscle cramp induction combined with fluid ingestion, FHB EMG activity was again similar (water = 55% +/- 9% and pickle juice = 66% +/- 9% of maximum voluntary isometric contraction EMG activity, P > 0.05).
  • However, cramp duration was 49.1 +/- 14.6 s shorter after pickle juice ingestion than water (84.6 +/- 18.5 vs 133.7 +/- 15.9 s, respectively, P < 0.05).
  • CONCLUSIONS: Pickle juice, and not deionized water, inhibits electrically induced muscle cramps in hypohydrated humans.
  • We suspect that the rapid inhibition of the electrically induced cramps reflects a neurally mediated reflex that originates in the oropharyngeal region and acts to inhibit the firing of alpha motor neurons of the cramping muscle.
  • [MeSH-major] Acetic Acid / therapeutic use. Dehydration / complications. Electric Stimulation / adverse effects. Muscle Cramp / etiology. Muscle Cramp / therapy

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  • (PMID = 19997012.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Electrolytes; Q40Q9N063P / Acetic Acid
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13. |......... 9%  Hawke F, Chuter V, Burns J: Impact of nocturnal calf cramping on quality of sleep and health-related quality of life. Qual Life Res; 2013 Aug;22(6):1281-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of nocturnal calf cramping on quality of sleep and health-related quality of life.
  • PURPOSE: To evaluate the impact of nocturnal calf cramping (a condition that affects one in two people over 60 years of age) on quality of sleep and health-related quality of life.
  • METHODS: Eighty adults who experienced nocturnal calf cramp at least once per week and eighty age- and sex-matched controls who never experienced nocturnal cramp were recruited from the Greater Newcastle and Central Coast regions of New South Wales, Australia.
  • RESULTS: People who experienced nocturnal muscle cramps reported more sleep disturbance (p < 0.001), less adequate sleep (p = 0.001), less quantity of sleep (p = 0.02) and more snoring (p = 0.03).
  • Both sleep problem summary indices for the MOS-SS identified people who experienced nocturnal muscle cramp as having more sleep problems than the controls.
  • People who experienced nocturnal muscle cramps had lower health-related quality of life for the SF-36 domains role physical (p = 0.007), bodily pain (p = 0.003) and general health (p = 0.02).
  • The impact of nocturnal calf cramps on health-related quality of life was largely explained by their negative impact on quality of sleep.
  • CONCLUSIONS: Nocturnal calf muscle cramps are associated with substantially reduced quality of sleep and reduced physical aspects of health-related quality of life.
  • [MeSH-major] Circadian Rhythm. Health Status. Muscle Cramp / psychology. Quality of Life. Sleep

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  • (PMID = 23011494.001).
  • [ISSN] 1573-2649
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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14. |......... 9%  Stone MB, Edwards JE, Huxel KC, Cordova ML, Ingersoll CD, Babington JP: Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise. J Sports Sci; 2010 Feb;28(4):399-405
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  • [Title] Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise.
  • Though clinical observations and laboratory data provide some support for the neuromuscular imbalance theory of the genesis of exercise-associated muscle cramps, no direct evidence has been published.
  • The purpose of this study was to determine the effect of local muscle fatigue on the threshold frequency of an electrically induced muscle cramp.
  • To determine baseline threshold frequency, a cramp was electrically induced in the flexor hallucis brevis of 16 apparently healthy participants (7 males, 9 females; age 25.1 +/- 4.8 years).
  • In the control condition, participants rested in a supine position for 30 min followed by another cramp induction to determine post-threshold frequency.
  • An increase in threshold frequency seems to demonstrate a decrease in one's propensity to cramp following the fatigue exercise regimen used.
  • These results contradict the proposed theory that suggests cramp propensity should increase following fatigue.
  • However, differences in laboratory versus clinical fatiguing exercise and contributions from other sources, as well as the notion of a graded response to fatiguing exercise, on exercise-associated muscle cramp and electrically induced muscle cramp should be considered.
  • [MeSH-major] Exercise / physiology. Muscle Contraction / physiology. Muscle Fatigue / physiology. Muscle, Skeletal / physiology

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  • (PMID = 20131142.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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15. |......... 8%  Zhang WW, Xu ZP, Cui YY, Wang H, Song MK, Li J, Shao BY, Xia Z, Chen HZ: Peripheral cholinoceptor antagonist anisodamine counteracts cholinergic adverse effects and facilitates cognitive amelioration of rivastigmine. J Neural Transm; 2009 Dec;116(12):1643-9
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  • Rivastigmine is a potent acetyl- and butyrylcholinesterase inhibitor widely used for cognitive improvement in Alzheimer's disease (AD) therapy.
  • Nevertheless, a high dose of rivastigmine (3.25 mg/kg) would compromise cognitive amelioration and produce obvious adverse effects, including hypersalivation, intestinal hyperperistalsis and muscle cramp.
  • [MeSH-minor] Animals. Avoidance Learning / drug effects. Cognition / drug effects. Drug Therapy, Combination. Intestines / drug effects. Intestines / physiology. Male. Mice. Mice, Inbred Strains. Muscle Cramp / chemically induced. Muscle Cramp / drug therapy. Random Allocation. Salivation / drug effects. Scopolamine Hydrobromide

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  • (PMID = 19756370.001).
  • [ISSN] 1435-1463
  • [Journal-full-title] Journal of neural transmission (Vienna, Austria : 1996)
  • [ISO-abbreviation] J Neural Transm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Cholinergic Antagonists; 0 / Neuroprotective Agents; 0 / Phenylcarbamates; 0 / Solanaceous Alkaloids; 01343Q8EL8 / anisodamine; 123441-03-2 / rivastigmine; 451IFR0GXB / Scopolamine Hydrobromide
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16. |......... 8%  Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Med Sci Sports Exerc; 2010 Nov;42(11):2056-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • PURPOSE: Dehydration is hypothesized to cause exercise-associated muscle cramps.
  • The theory states that dehydration contracts the interstitial space, thereby increasing the pressure on nerve terminals and cramps ensue.
  • Inducing cramps with electrical stimulation minimizes many of the confounding factors associated with exercise-induced cramps (e.g., fatigue, metabolites).
  • Thus, our goal was to minimize fatigue and determine whether hypohydration decreases the electrical stimuli required to elicit cramping (termed "threshold frequency").
  • Dominant leg flexor hallucis brevis muscle cramps were induced before and after hypohydration, and threshold frequency was recorded.
  • CONCLUSIONS: Mild hypohydration with minimal neuromuscular fatigue does not seem to predispose individuals to cramping.
  • Thus, cramps may be more associated with neuromuscular fatigue than dehydration/electrolyte losses.
  • Health care professionals may have more success preventing exercise-associated muscle cramp by focusing on strategies that minimize neuromuscular fatigue rather than dehydration.
  • However, the effect of greater fluid losses on cramp threshold frequency is unknown and merits further research.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology. Muscle Fatigue

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  • (PMID = 20351595.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. |......... 8%  Hung CY, Chen YL, Chen CS, Yang CS, Peng SJ: Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. Blood Purif; 2009;27(2):159-64
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  • [Title] Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study.
  • BACKGROUND/AIMS: The mechanism of muscle cramp in hemodialysis patients is not well understood.
  • This study aimed to determine the association between leptin and hemodialysis-related muscle cramps.
  • The episodes of hemodialysis-related muscle cramps were recorded over a 28-day period.
  • RESULTS: Frequent hemodialysis-related cramps were associated with old age and elevated serum leptin levels.
  • The risk of frequent hemodialysis-related cramps increased with increasing tertiles of leptin concentration.
  • This relationship remained significant after adjustment for age, mean ultrafiltration ratio, gender, body mass index, insulin, resistin, c-reactive protein, albumin, peripheral arterial disease, electrolytes, and beta(2)-microglobulin.
  • CONCLUSION: Leptin levels are associated with frequent hemodialysis-related cramps.
  • [MeSH-major] Kidney Failure, Chronic / complications. Leptin / blood. Muscle Cramp / etiology. Renal Dialysis / adverse effects

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  • (PMID = 19141993.001).
  • [ISSN] 1421-9735
  • [Journal-full-title] Blood purification
  • [ISO-abbreviation] Blood Purif.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Leptin
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18. |......... 8%  Blyton F, Chuter V, Walter KE, Burns J: Non-drug therapies for lower limb muscle cramps. Cochrane Database Syst Rev; 2012;1:CD008496
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-drug therapies for lower limb muscle cramps.
  • BACKGROUND: About one in every three adults are affected by lower limb muscle cramps.
  • For some people, these cramps reduce quality of life, quality of sleep and participation in activities of daily living.
  • Many interventions are available for lower limb cramps, but some are controversial, no treatment guidelines exist, and often people experience no benefit from the interventions prescribed.
  • OBJECTIVES: To assess the effects of non-drug, non-invasive treatments for lower limb cramp.
  • SEARCH METHODS: We searched the Cochrane Neuromuscular Disease Group Specialized Register (13 September 2011) using the terms: cramp, spasm, contracture, charley horse and lower limb, lower extremity, foot, calf, leg, thigh, gastrocnemius, hamstring, quadriceps.
  • SELECTION CRITERIA: All randomised controlled trials of non-drug, non-invasive interventions trialled over at least four weeks for the prevention of lower limb muscle cramps in any group of people.
  • We selected only trials that included at least one of the following outcomes: cramp frequency, cramp severity, health-related quality of life, quality of sleep, participation in activities of daily living and adverse outcomes.
  •  All participants were age 60 years or over and had received a repeat prescription from their general practitioner of quinine for nighttime cramps in the preceding three months.
  • Forty-nine participants were advised to complete lean-to-wall calf muscle stretching held for 10 s three times per day.
  • After 12 weeks, there was no statistically significant difference in recalled cramp frequency between groups.
  • AUTHORS' CONCLUSIONS: There is limited evidence on which to base clinical decisions regarding the use of non-drug therapies for the treatment of lower limb muscle cramp.
  • [MeSH-major] Lower Extremity. Muscle Cramp / therapy. Muscle Stretching Exercises / methods
  • [MeSH-minor] Aged. Humans. Middle Aged. Muscle Relaxants, Central / therapeutic use. Quinine / therapeutic use. Randomized Controlled Trials as Topic

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  • (PMID = 22258986.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscle Relaxants, Central; A7V27PHC7A / Quinine
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19. |......... 7%  Hokari S, Koya T, Shimaoka Y, Nakayama H, Terada M, Suzuki E: [Interstitial pneumonia associated with stiff-person syndrome]. Nihon Kokyuki Gakkai Zasshi; 2010 Feb;48(2):162-5
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  • Three months after the diagnosis of interstitial pneumonia, he noticed neurological symptoms, such as facial spasms, dysphagia, muscle rigidity and muscle cramp, and repeatedly received clonazepam.

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  • (PMID = 20184250.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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20. |......... 7%  Ge HY, Arendt-Nielsen L: Latent myofascial trigger points. Curr Pain Headache Rep; 2011 Oct;15(5):386-92
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  • A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination.
  • Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle fiber contraction and/or muscle cramp potentials, which contribute significantly to the induction of local tenderness and pain and motor dysfunctions.

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  • (PMID = 21559783.001).
  • [ISSN] 1534-3081
  • [Journal-full-title] Current pain and headache reports
  • [ISO-abbreviation] Curr Pain Headache Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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21. |......... 6%  Liu SL, Chen G, Zhao YP, Wu WM, Zhang TP: Optimized dose of imatinib for treatment of gastrointestinal stromal tumors: a meta-analysis. J Dig Dis; 2013 Jan;14(1):16-21
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  • The rates of rash, hemorrhage, nausea, vomiting and taste disturbance increased as dose increased (P < 0.05), whereas the incidence of headache, abdominal pain, edema, fatigue, anemia, infection, muscle cramp and constipation was nearly identical and showed no significant difference.

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  • [Copyright] © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
  • (PMID = 23121684.001).
  • [ISSN] 1751-2980
  • [Journal-full-title] Journal of digestive diseases
  • [ISO-abbreviation] J Dig Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; BKJ8M8G5HI / imatinib
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22. |......... 6%  Arimura K, Watanabe O: [Immune-mediated neuromyotonia (Isaacs' syndrome)--clinical aspects and pathomechanism]. Brain Nerve; 2010 Apr;62(4):401-10
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  • Isaacs' syndrome (immune-mediated neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy).
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction (pseudomyotonia), and hyperhidrosis; these symptoms are due to hyperexcitability of the peripheral nerve, including autonomic nerve.
  • Recent studies show that this disease is not infrequently associated with neoplasm, especially thymoma.

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  • (PMID = 20420181.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Potassium Channels; 0 / Potassium Channels, Voltage-Gated
  • [Number-of-references] 32
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23. |......... 6%  Miller KC, Burne JA: Golgi tendon organ reflex inhibition following manually applied acute static stretching. J Sports Sci; 2014 Aug;32(15):1491-7
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  • Abstract Golgi tendon organ disinhibition may contribute to exercise-associated muscle cramp (henceforth referred to as "cramps") genesis.
  • Static stretching pre-exercise is prescribed to prevent cramps based on the assumption golgi tendon organ inhibition remains elevated post-stretching.
  • If pre-stretching does prevent fatigue-induced cramping, the mechanism is unlikely to involve the autoinhibition produced by the golgi tendon organ reflex.
  • Further empirical research is needed to validate the proposed link between static stretching and cramping and then to investigate alternative mechanisms.

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  • (PMID = 24716521.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; alpha motor neuron / electrical stimulation / muscle cramp / tendon afferents
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24. |......... 6%  Takashima H: [History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)]. Rinsho Shinkeigaku; 2013;53(11):1196-8
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  • We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan.
  • This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484).
  • Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required.
  • Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA).
  • Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time.

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  • (PMID = 24291927.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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25. |......... 6%  Watanabe O: [Isaacs's syndrome and associated diseases]. Rinsho Shinkeigaku; 2013;53(11):1067-70
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  • Isaacs' syndrome is an antibody-mediated potassium channel disorder.
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction, and hyperhidrosis.

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  • (PMID = 24291881.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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26. |......... 6%  Hara K, Watanabe O, Shibano K, Ishiguro H: [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity]. Rinsho Shinkeigaku; 2012;52(9):677-80
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  • [Title] [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity].
  • A 21-year-old man complained of severe pain and muscle twitching localized in his right arm.
  • Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia.
  • Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges.
  • This case with neither muscle cramp nor myokymia expands the phenotype of anti VGKC-complex antibody associated disorder.

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  • HSDB. structure - METHYLPREDNISOLONE.
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  • (PMID = 22989904.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biological Markers; 0 / Immunoglobulins, Intravenous; 0 / Potassium Channels, Voltage-Gated; X4W7ZR7023 / Methylprednisolone
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27. |......... 5%  Ichikawa T, Naota T, Miyaaki H, Miuma S, Isomoto H, Takeshima F, Nakao K: Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance. Hepatol Res; 2010 Oct;40(10):971-8
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  • The items, as major symptoms of cirrhotic patients, were as follows: hand tremor, appetite loss, muscle cramp of foot, fatigue, decreased strength, anxiety, abdominal fullness, abdominal pain and a feeling of low energy.
  • However, the cirrhotic symptom-related score was positively relation with the Child-Pugh score at the time of patient entry, and we were unable to identify the item that related to ESS.

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  • [Copyright] © 2010 The Japan Society of Hepatology.
  • (PMID = 20887332.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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28. |......... 5%  Kim HJ, Kim CK, Carpentier A, Poortmans JR: Studies on the safety of creatine supplementation. Amino Acids; 2011 May;40(5):1409-18
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  • Anecdotal reports from athletes have appeared on muscle cramp and gastrointestinal complaints during creatine supplementation, but the incidence of these is limited and not necessarily linked to creatine itself.
  • We advise that high-dose (>3-5 g/day) creatine supplementation should not be used by individuals with pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate).

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  • (PMID = 21399917.001).
  • [ISSN] 1438-2199
  • [Journal-full-title] Amino acids
  • [ISO-abbreviation] Amino Acids
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] MU72812GK0 / Creatine
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29. |......... 4%  Leong D, Vaz Pardal C, Tan B, Lin C: Injury and illness patterns in competitive sailors of the 43rd isaf youth sailing world championship - a 12-month retrospective study. Br J Sports Med; 2014 Apr;48(7):625
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  • The top 3 injury types were sprain (21%), muscle strain/tear (16%), and muscle cramp/spasm (16%).
  • Of the nine illnesses, sunburn was the most common symptom (29%) and the dermatological system was most commonly affected (44%).

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  • (PMID = 24620218.001).
  • [ISSN] 1473-0480
  • [Journal-full-title] British journal of sports medicine
  • [ISO-abbreviation] Br J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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30. |......... 4%  Diener HC, Westphal K: [Differential diagnosis and treatment of cramps]. MMW Fortschr Med; 2013 Oct 10;155 Suppl 3:83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differential diagnosis and treatment of cramps].
  • [Transliterated title] Differenzialdiagnose und Therapie von Muskelkrämpfen (Crampi).
  • Cramps are painful sensations caused by intense involuntary contractions of skeletal muscles, mostly in the calves, usually lasting from a few seconds to several minutes.
  • Although cramps are mostly idiopathic, theycan bea symptom of other forms of myalgia, restless legs syndrome or spasticity.
  • Especially nocturnal cramps can cause considerable distress for patients requiring fast pain reduction and effective prophylaxis.
  • Stretching the calf muscles helps preventing nocturnal cramps.
  • Pharmacological treatment of leg cramps includes magnesium and quinine.
  • [MeSH-major] Muscle Cramp / etiology. Muscle Cramp / therapy
  • [MeSH-minor] Adult. Aged. Analgesics, Non-Narcotic / adverse effects. Analgesics, Non-Narcotic / therapeutic use. Diagnosis, Differential. Female. Humans. Magnesium / adverse effects. Magnesium / therapeutic use. Male. Middle Aged. Muscle Stretching Exercises. Polysomnography. Pregnancy. Quinine / adverse effects. Quinine / therapeutic use. Randomized Controlled Trials as Topic. Sleep Disorders / diagnosis. Sleep Disorders / etiology. Sleep Disorders / therapy

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  • HSDB. structure - QUININE.
  • HSDB. structure - MAGNESIUM, ELEMENTAL.
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  • (PMID = 24930318.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; A7V27PHC7A / Quinine; I38ZP9992A / Magnesium
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31. |......... 4%  Reichel G: [Muscle cramps--differential diagnosis and therapy]. Med Monatsschr Pharm; 2009 Mar;32(3):80-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Muscle cramps--differential diagnosis and therapy].
  • Calf cramps are sudden, involuntary, painful contractions of part of or the entire calf muscle that are visible, persist for seconds to minutes and then spontaneously resolve.
  • They can occur with no identifiable cause, and are then referred to as common calf cramps.
  • They may also be symptoms associated with diseases of the peripheral and central nervous system and muscle diseases.
  • In such cases the cramps are more extensive, intense and persist for longer.
  • Cramp-fasciculation-myalgia syndrome additionally involves paresthesias and other signs of hyperexcitability of peripheral nerves.
  • The recommended treatment for patients with frequent calf cramps causing significant impairment of well-being is oral administration of quinidine and/or botulinum toxin treatment of the calf muscles.
  • [MeSH-major] Muscle Cramp / diagnosis. Muscle Cramp / therapy

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  • (PMID = 19402333.001).
  • [ISSN] 0342-9601
  • [Journal-full-title] Medizinische Monatsschrift für Pharmazeuten
  • [ISO-abbreviation] Med Monatsschr Pharm
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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32. |......... 4%  Miller KC, Knight KL: Initial electrical stimulation frequency and cramp threshold frequency and force. J Athl Train; 2012 Nov-Dec;47(6):643-7
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  • [Title] Initial electrical stimulation frequency and cramp threshold frequency and force.
  • CONTEXT: In the electrically induced cramp model, the tibial nerve is stimulated at an initial frequency of 4 Hz with increases in 2-Hz increments until the flexor hallucis brevis cramps.
  • The frequency at which cramping occurs (ie, threshold frequency [TF]) can vary considerably.
  • Patients or Other Participants: Twenty participants (13 males: age = 20.6 ± 2.9 years, height = 184.4 ± 5.7 cm, mass = 76.3 ± 7.1 kg; 7 females: age = 20.4 ± 3.5 years, height = 166.6 ± 6.0 cm, mass = 62.4 ± 10.0 kg) who were prone to cramps.
  • Participants were stimulated at either 4 Hz or 14 Hz, and the frequency was increased in 2-Hz increments from each initial frequency until cramp.
  • The MVIC force was lower at 1 minute postcramp, suggesting the induced cramp rather than the varying electrical frequencies affected force.
  • A 1- to 5-minute rest should be provided postcramp induction if multiple cramps are induced.
  • [MeSH-major] Electric Stimulation / adverse effects. Isometric Contraction / physiology. Muscle Cramp / etiology. Tibial Nerve
  • [MeSH-minor] Cross-Over Studies. Electromyography. Fatigue. Female. Humans. Male. Muscle Contraction / physiology. Muscle, Skeletal / physiology. Young Adult

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  • (PMID = 23182012.001).
  • [ISSN] 1938-162X
  • [Journal-full-title] Journal of athletic training
  • [ISO-abbreviation] J Athl Train
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3499888
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33. |......... 4%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Muscle Properties': Top Publications. BioMedLib Review; OrganicChemical;MuscleProperties:705638735. ISSN: 2331-5717. 2014/4/25
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  • [Title] 'Organic Chemicals' associated with 'Muscle Properties': Top Publications.
  • Background: There are articles published each month which present 'organic chemical' for 'muscle properties'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Karges K et al: Effects of supplemental vitamin D3 on feed intake, carcass characteristics, tenderness, and muscle properties of beef steers.
  • Coombes JS et al: Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties.
  • Shapiro BP et al: Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines.
  • Mendelev NN et al: Antigrowth properties of BAY 41-2272 in vascular smooth muscle cells.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • Tan Y et al: Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide.
  • Swieca A et al: AMP-deaminase from hen stomach smooth muscle--physico-chemical properties of the enzyme.
  • Wagner H et al: Biomechanical muscle properties and angiotensin-converting enzyme gene polymorphism: a model-based study.
  • Chabas JF et al: FK506 induces changes in muscle properties and promotes metabosensitive nerve fiber regeneration.
  • Treves S et al: Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705638735.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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34. |......... 4%  Minetto MA, Holobar A, Botter A, Farina D: Origin and development of muscle cramps. Exerc Sport Sci Rev; 2013 Jan;41(1):3-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Origin and development of muscle cramps.
  • Cramps are sudden, involuntary, painful muscle contractions.
  • One hypothesis is that cramps result from changes in motor neuron excitability (central origin).
  • The central origin hypothesis has been supported by recent experimental findings, whose implications for understanding cramp contractions are discussed.
  • [MeSH-major] Muscle Cramp / physiopathology
  • [MeSH-minor] Electromyography. Exercise / physiology. Humans. Motor Neurons / physiology. Muscle, Skeletal / innervation. Muscle, Skeletal / physiopathology. Nerve Block

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  • (PMID = 23038243.001).
  • [ISSN] 1538-3008
  • [Journal-full-title] Exercise and sport sciences reviews
  • [ISO-abbreviation] Exerc Sport Sci Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
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35. |......... 3%  Cooper IF, Siadaty MS: 'Diagnostic Procedures' associated with 'M Temporalis': Top Publications. BioMedLib Review; DiagnosticProcedure;MTemporalis:705245724. ISSN: 2331-5717. 2014/2/26
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  • Roeleveld K et al: Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics.
  • Regalo SC et al: Electromyographic analysis of the masseter and temporal muscles in oralized deaf individuals.
  • Stålberg E et al: Electrophysiological study of size and fibre distribution of motor units in the human masseter and temporal muscles.
  • Krechina EK et al: [Electromyographic evaluation of functional status of temporal muscles and mastication muscles in patients with close position of frontal teeth in cases of different occlusion].
  • de Oliveira RH et al: Electromyographic analysis of masseter and temporal muscles, bite force, masticatory efficiency in medicated individuals with schizophrenia and mood disorders compared with healthy controls.
  • Kalamkarov KhA et al: [Electromyography and electrotonometry of the masticatory muscles and the anterior part of temporal muscles in children aged 7-12 with prognathic bite].
  • Hagberg C et al: Surface EMG frequency dependence on force in the masseter and the anterior temporal muscles.
  • Miller AJ: Spectral analysis of the electromyogram of the temporal muscle in the rhesus monkey (Macaca mulatta).

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705245724.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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36. |......... 3%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Atrophy Muscle Peroneal': Top Publications. BioMedLib Review; Tissue;AtrophyMusclePeroneal:706260786. ISSN: 2331-5717. 2014/11/24
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  • [Title] 'Tissues' associated with 'Atrophy Muscle Peroneal': Top Publications.
  • There are articles published each month which present 'Tissue' for 'atrophy muscle peroneal'.
  • Cooper IF et al: 'Steroids' associated with 'Atrophy Muscle Peroneal': Top Publications.
  • van der Linden MH et al: Fast responses to stepping on an unexpected surface height depend on intact large-diameter nerve fibers: a study on Charcot-Marie-Tooth type 1A disease.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Shen H et al: Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E.
  • Tinelli E et al: Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves.
  • Paulson HL et al: Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease.
  • Sacco S et al: Brain white matter lesions in an italian family with charcot-marie-tooth disease.
  • Berciano J et al: Clinico-electrophysiological correlation of extensor digitorum brevis muscle atrophy in children with charcot-marie-tooth disease 1A duplication.
  • Basri R et al: X-linked Charcot-Marie-Tooth disease (CMTX) in a severely affected female patient with scattered lesions in cerebral white matter.
  • Maggs AM et al: Nerve-dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross-reinnervation and in a demyelinating mouse model of Charcot-Marie-Tooth disease type 1A.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706260786.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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37. |......... 3%  Ochsner F: [The mucisian's cramp. About the illness of Robert Schumann]. Rev Med Suisse; 2012 Jan 11;8(323):66-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The mucisian's cramp. About the illness of Robert Schumann].
  • [Transliterated title] La crampe du musicien. A propos de la maladie de Robert Schumann.
  • The history of the German Romantic composer Robert Schumann illustrates this reality; through his story a discussion of both the different pathophysiological hypotheses responsible for focal dystonia, a disorder of brain plasticity, and of the multimodal therapeutic approaches, revisited in the light of neurophysiological findings will be described.
  • [MeSH-major] Famous Persons. Muscle Cramp / history. Music / history. Occupational Diseases / history

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  • (PMID = 22303744.001).
  • [ISSN] 1660-9379
  • [Journal-full-title] Revue médicale suisse
  • [ISO-abbreviation] Rev Med Suisse
  • [Language] fre
  • [Publication-type] Biography; English Abstract; Historical Article; Journal Article
  • [Publication-country] Switzerland
  • [Personal-name-as-subject] Schumann R
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38. |......... 3%  Chatrath H, Liangpunsakul S, Ghabril M, Otte J, Chalasani N, Vuppalanchi R: Prevalence and morbidity associated with muscle cramps in patients with cirrhosis. Am J Med; 2012 Oct;125(10):1019-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and morbidity associated with muscle cramps in patients with cirrhosis.
  • PURPOSE: Patients with cirrhosis often experience muscle cramps with varying severity.
  • We investigated the factors associated with the prevalence and morbidity associated with muscle cramps.
  • Cramp questionnaire with visual analogue scale for pain, Chronic Liver Disease Questionnaire (CLDQ), and blood for measurement of 25-(OH) vitamin D levels were obtained after informed consent.
  • RESULTS: A total of 101 patients (67%) reported muscle cramps in the preceding 3 months.
  • Patients with cramps had significantly lower serum albumin (3.1±0.6 g/dL vs 3.3±0.7 g/dL, P=.04) and CLDQ scores (107±37 vs 137±34, P<.0001) compared with those without cramps.
  • The median composite symptom score, defined as product of frequency and severity of cramps, in the study cohort was 12 with a range of 0.3 to 200.
  • There were no clinical or biochemical predictors for occurrence of any cramps or severe cramps (composite symptom score>12).
  • Muscle cramps (P<.001) and hepatic encephalopathy (P=.009) were associated independently with decreased CLDQ scores.
  • Vitamin D deficiency was seen in 66% of the study cohort, but the serum 25-(OH) vitamin D levels were not significantly different between patients with and without cramps (18.0±8.9 ng/mL vs 19.6±9.5 ng/mL, P=.49).
  • CONCLUSIONS: Muscle cramps are associated with significantly diminished quality of life in patients with cirrhosis.
  • [MeSH-major] Liver Cirrhosis / complications. Muscle Cramp / etiology. Vitamin D Deficiency / complications

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
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  • (PMID = 22835465.001).
  • [ISSN] 1555-7162
  • [Journal-full-title] The American journal of medicine
  • [ISO-abbreviation] Am. J. Med.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / K24 DK069290; United States / NIDDK NIH HHS / DK / K24 DK069290
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS510153; NLM/ PMC3932181
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39. |......... 3%  Lopate G, Streif E, Harms M, Weihl C, Pestronk A: Cramps and small-fiber neuropathy. Muscle Nerve; 2013 Aug;48(2):252-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cramps and small-fiber neuropathy.
  • INTRODUCTION: Muscle cramps are a common complaint and are thought to arise from spontaneous discharges of the motor nerve terminal.
  • METHODS: We performed skin biopsies on consecutive patients with cramps but without neuropathic complaints.
  • A cause for neuropathy was found in 1 patient with cramp-fasciculation syndrome.
  • Muscle biopsy, performed in 8 patients, but was diagnostic in only 1, with McArdle disease.
  • CONCLUSIONS: Our data show that 60% of patients with muscle cramps who lack neuropathic complaints have SFN, as documented by decreased IENFD.
  • Cramps may originate as local mediators of inflammation released by damaged small nerve that excite intramuscular nerves.
  • [MeSH-major] Muscle Cramp / complications. Muscle Cramp / diagnosis. Peripheral Nervous System Diseases / complications. Peripheral Nervous System Diseases / diagnosis

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  • [Copyright] © 2013 Wiley Periodicals, Inc.
  • (PMID = 23813593.001).
  • [ISSN] 1097-4598
  • [Journal-full-title] Muscle & nerve
  • [ISO-abbreviation] Muscle Nerve
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.3.2 / Creatine Kinase
  • [Keywords] NOTNLM ; muscle cramps / peripheral nervous system disease / skin biopsy / small-fiber neuropathy / unmyelinated nerve fibers
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40. |......... 3%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Abnormally Low Blood Calcium Levels': Top Publications. BioMedLib Review; Tissue;AbnormallyLowBlood:705773764. ISSN: 2331-5717. 2014/4/27
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  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Zekri JM et al: Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour.
  • Wassner SJ et al: Vitamin D Deficiency, hypocalcemia, and increased skeletal muscle degradation in rats.
  • Cascio WE et al: Passive electrical properties, mechanical activity, and extracellular potassium in arterially perfused and ischemic rabbit ventricular muscle. Effects of calcium entry blockade or hypocalcemia.
  • Ishikawa T et al: Effect of hypocalcemia on muscle in disorders of calcium metabolism.
  • Arutiunian RS et al: [Functional state of muscle receptors in experimental hypocalcemia].
  • Sakai Y et al: [A case of thyrotoxicosis with prolonged muscle cramp and hypocalcemia after treatment with methimazole].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705773764.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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41. |......... 3%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Alopecia Disorder': Top Publications. BioMedLib Review; Tissue;AlopeciaDisorder:705765937. ISSN: 2331-5717. 2014/4/27
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  • [Title] 'Tissues' associated with 'Alopecia Disorder': Top Publications.
  • Background: There are articles published each month which present 'tissue' for 'alopecia disorder'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Galitovskiy V et al: Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.
  • Yazdabadi A et al: Miniaturized Hairs Maintain Contact with the Arrector Pili Muscle in Alopecia Areata but not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth.
  • Kumar B et al: Antismooth muscle and antiparietal cell antibodies in Indians with alopecia areata.
  • Takahashi J et al: [Three siblings of painful muscle cramps (generalized muscle cramp disease) with alopecia and endocrinological disorders].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705765937.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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42. |......... 3%  Cooper IF, Siadaty MS: 'Diagnostic Procedures' associated with 'Surface Characteristics': Top Publications. BioMedLib Review; DiagnosticProcedure;SurfaceCharacteristics:705368687. ISSN: 2331-5717. 2014/4/27
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  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Roeleveld K et al: Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705368687.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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43. |......... 3%  Minetto MA, Botter A, De Grandis D, Merletti R: Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps. Neurophysiol Clin; 2009 Feb;39(1):15-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps.
  • OBJECTIVES: To examine if different frequencies of electrical stimulation trigger different sized cramps in the abductor hallucis muscle and to analyze their surface electromyographic (EMG) behaviour in both time and frequency domains.
  • Stimulation trains of 150 pulses were applied to the muscle motor point.
  • Frequency was increased (starting from 4pps with 2-pps steps) until a cramp developed.
  • After the first cramp ("threshold cramp"), a 30-minute rest was provided before a second cramp ("above-threshold cramp") was elicited with a frequency increased by 50% with respect to that eliciting the first cramp.
  • RESULTS: We found greater EMG amplitude and a compression of the power spectrum for above-threshold cramps with respect to threshold cramps.
  • Significant positive correlations were found between estimates of EMG amplitude during cramps and estimated reductions of M-wave amplitude.
  • CONCLUSIONS: Varying frequencies of electrical stimulation triggered different sized cramps.
  • Moreover, decreases in M-wave amplitude were observed during both threshold and above-threshold stimulations.
  • The choice of the stimulation frequency has relevance for optimizing electrical stimulation protocols for the study of muscle cramps in both healthy and pathological subjects.
  • [MeSH-major] Electric Stimulation. Muscle Cramp / physiopathology
  • [MeSH-minor] Adult. Algorithms. Ankle Joint / physiology. Electromyography. Female. Foot / physiology. Humans. Leg / physiology. Male. Muscle, Skeletal / physiology. Skin Temperature / physiology. Young Adult

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  • (PMID = 19268843.001).
  • [ISSN] 0987-7053
  • [Journal-full-title] Neurophysiologie clinique = Clinical neurophysiology
  • [ISO-abbreviation] Neurophysiol Clin
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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44. |......... 3%  Minetto MA, Holobar A, Botter A, Farina D: Discharge properties of motor units of the abductor hallucis muscle during cramp contractions. J Neurophysiol; 2009 Sep;102(3):1890-901
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Discharge properties of motor units of the abductor hallucis muscle during cramp contractions.
  • We analyzed individual motor units during electrically elicited cramp contractions with the aim of characterizing the variability and degree of common oscillations in their discharges.
  • Intramuscular and surface electromyographic (EMG) signals were detected from the abductor hallucis muscle of 11 healthy subjects (age 27.0+/-3.7 yr) during electrically elicited cramps.
  • In conclusion, motor units active during cramps showed a range of discharge rates similar to that observed during voluntary contractions but larger ISI variability, probably due to large synaptic noise.
  • [MeSH-major] Motor Neurons / physiology. Muscle Contraction / physiology. Muscle Cramp / physiopathology. Muscle, Skeletal / physiopathology

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  • (PMID = 19571196.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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45. |......... 3%  Minetto MA, Holobar A, Botter A, Ravenni R, Farina D: Mechanisms of cramp contractions: peripheral or central generation? J Physiol; 2011 Dec 1;589(Pt 23):5759-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mechanisms of cramp contractions: peripheral or central generation?
  • We analysed the cramp threshold (i.e. the minimum frequency of electrical stimulation capable of inducing a cramp) and the behaviour of individual motor units during cramps electrically elicited in the absence (intact condition) and presence (blocked condition) of a peripheral nerve block in eight healthy subjects.
  • The cramp threshold was significantly greater in the blocked than in the intact condition (18 ± 3 Hz vs. 13 ± 3 Hz; P = 0.01).
  • Cramp duration and peak EMG amplitude in the intact condition (55.6 ± 19.2 s and 47.5 ± 24.8 μV, respectively) were significantly greater compared to the blocked condition (2.6 ± 1.3 s and 13.9 ± 8.8 μV; P < 0.01).
  • These results indicate a spinal involvement at the origin of cramps and during their development.
  • [MeSH-major] Motor Neurons / physiology. Muscle Cramp / physiopathology. Muscle, Skeletal / innervation. Spinal Cord / physiology
  • [MeSH-minor] Adult. Anesthetics / pharmacology. Electric Stimulation. Electromyography. Humans. Male. Muscle Contraction / physiology. Nerve Block. Peripheral Nervous System / physiology. Tibial Nerve / drug effects. Tibial Nerve / physiology

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  • (PMID = 21969448.001).
  • [ISSN] 1469-7793
  • [Journal-full-title] The Journal of physiology
  • [ISO-abbreviation] J. Physiol. (Lond.)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anesthetics
  • [Other-IDs] NLM/ PMC3249048
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46. |......... 3%  Shang G, Collins M, Schwellnus MP: Factors associated with a self-reported history of exercise-associated muscle cramps in Ironman triathletes: a case-control study. Clin J Sport Med; 2011 May;21(3):204-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors associated with a self-reported history of exercise-associated muscle cramps in Ironman triathletes: a case-control study.
  • OBJECTIVE: Exercise-associated muscle cramping (EAMC) is a common medical condition in endurance athletes.
  • CONCLUSIONS: There is evidence from this study that a history of EAMC is associated with (1) exercising at a higher intensity during a race that may result in premature muscle fatigue, (2) an inherited risk (positive family history), and (3) a history of tendon and/or ligament injury.
  • [MeSH-major] Athletes. Athletic Injuries / etiology. Muscle Cramp / epidemiology
  • [MeSH-minor] Adult. Body Height / physiology. Body Weight / physiology. Case-Control Studies. Female. Humans. Male. Middle Aged. Muscle Fatigue / physiology. Muscle Stretching Exercises. Physical Endurance / physiology. Risk Factors. Running / physiology

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  • [Copyright] 2011 by Lippincott Williams & Wilkins.
  • (PMID = 21430526.001).
  • [ISSN] 1536-3724
  • [Journal-full-title] Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
  • [ISO-abbreviation] Clin J Sport Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. |......... 3%  Cooper IF, Siadaty MS: 'Signs or Symptoms' associated with 'M Temporalis': Top Publications. BioMedLib Review; SignOrSymptom;MTemporalis:705289343. ISSN: 2331-5717. 2014/7/24
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  • There are articles published each month which present 'Sign or Symptom' for 'm temporalis'.
  • Roeleveld K et al: Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics.
  • Nisijima K et al: Temporal changes in serum creatine kinase concentration and degree of muscle rigidity in 24 patients with neuroleptic malignant syndrome.
  • Sethi PK et al: Cysticercosis of temporalis muscle: an unusual cause of temporal headaches. A case report.
  • Jensen K et al: Pain and tenderness in human temporal muscle induced by bradykinin and 5-hydroxytryptamine.
  • Graven-Nielsen T et al: Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients.
  • Nie H et al: Temporal summation of pressure pain during muscle hyperalgesia evoked by nerve growth factor and eccentric contractions.
  • Freund B et al: Temporal relationship of muscle weakness and pain reduction in subjects treated with botulinum toxin A.
  • Bishop MD et al: Dynamic, but not static, pain sensitivity predicts exercise-induced muscle pain: covariation of temporal sensory summation and pain intensity.
  • Liang N et al: Temporal modulations of agonist and antagonist muscle activities accompanying improved performance of ballistic movements.
  • Kato T et al: Temporal changes in the excitability of the reciprocal inhibitory interneurones preceding cocontraction of the antagonistic muscle in the human wrist.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705289343.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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48. |......... 3%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Charcot Marie Tooth Muscular Atrophy': Top Publications. BioMedLib Review; Tissue;CharcotMarieTooth:706253269. ISSN: 2331-5717. 2014/11/24
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  • [Title] 'Tissues' associated with 'Charcot Marie Tooth Muscular Atrophy': Top Publications.
  • There are articles published each month which present 'Tissue' for 'charcot marie tooth muscular atrophy'.
  • van der Linden MH et al: Fast responses to stepping on an unexpected surface height depend on intact large-diameter nerve fibers: a study on Charcot-Marie-Tooth type 1A disease.
  • Maggs AM et al: Nerve-dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross-reinnervation and in a demyelinating mouse model of Charcot-Marie-Tooth disease type 1A.
  • Basri R et al: X-linked Charcot-Marie-Tooth disease (CMTX) in a severely affected female patient with scattered lesions in cerebral white matter.
  • Shen H et al: Muscle pathology without severe nerve pathology in a new mouse model of Charcot-Marie-Tooth disease type 2E.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Bach D et al: Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
  • Tinelli E et al: Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves.
  • Menotti F et al: The role of the prefrontal cortex in the development of muscle fatigue in Charcot-Marie-Tooth 1A patients.
  • Borg K et al: Muscle biopsy abnormalities differ between Charcot-Marie-Tooth type 1 and 2: reflect different pathophysiology?.
  • Berciano J et al: Clinico-electrophysiological correlation of extensor digitorum brevis muscle atrophy in children with charcot-marie-tooth disease 1A duplication.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706253269.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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49. |......... 3%  Cooper IF, Siadaty MS: 'Pharmacologic Substances' associated with 'Shakuyaku Kanzo To': Top Publications. BioMedLib Review; PharmacologicSubstance;ShakuyakuKanzoTo:706172749. ISSN: 2331-5717. 2014/12/23
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  • Tsuji S et al: Shakuyaku-kanzo-to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro.
  • Hyodo T et al: Immediate effect of Shakuyaku-kanzo-to on muscle cramp in hemodialysis patients.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706172749.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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50. |......... 3%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Shakuyaku Kanzo To': Top Publications. BioMedLib Review; OrganicChemical;ShakuyakuKanzoTo:706171063. ISSN: 2331-5717. 2014/11/23
PDF icon [Fulltext service] Download fulltext PDF of this article.

  • Tsuji S et al: Shakuyaku-kanzo-to inhibits smooth muscle contractions of human pregnant uterine tissue in vitro.
  • Hyodo T et al: Immediate effect of Shakuyaku-kanzo-to on muscle cramp in hemodialysis patients.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706171063.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
  •  go-up   go-down


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