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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||||||. 100%  Blyton F, Chuter V, Burns J: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness. J Foot Ankle Res; 2012;5:7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • BACKGROUND: Night-time calf cramping affects approximately 1 in 3 adults.
  • The aim of this study was to explore the experience of night-time calf cramp; if and where people seek treatment advice; and perceived treatment effectiveness.
  • METHODS: 80 adults who experienced night-time calf cramp at least once per week were recruited from the Hunter region, NSW, Australia through newspaper, radio and television advertisements.
  • All participants completed a pilot-tested survey about muscle cramp.
  • RESULTS: Median recalled age of first night-time calf cramp was 50 years.
  • Most participants recalled being awoken from sleep by cramping, and experiencing cramping of either calf muscle, calf-muscle soreness in the days following cramp and cramping during day-time.
  • Participants described their cramps as being 'unbearable', 'unmanageable' and 'cruel'.
  • One participant stated that 'sometimes I just wish I could cut my legs open' and another reported 'getting about 2 h sleep a night due to cramps'.
  • Most participants had sought advice about their night-time calf cramps from a health professional.
  • Participants identified 49 different interventions used to prevent night-time calf cramp.
  • Of all treatment ratings, 68% described the intervention used to prevent cramp as being 'useless' or of 'a little help'.
  • Of 14 participants who provided additional information regarding their use of quinine, eight had a current prescription of quinine for muscle cramp at the time of the survey.
  • CONCLUSION: Night time calf cramps typically woke sufferers from sleep, affected either leg and caused ongoing pain.
  • Most participants experienced little or no relief with current therapies used to prevent muscle cramp.
  • Most people who were taking quinine for muscle cramp were unaware that the Australian Therapeutic Goods Administration withdrew support of quinine for muscle cramp in 2004 due to the risk of thrombocytopaenia.
  • Case-control studies are required to identify therapeutic targets so that clinical trials can evaluate safe interventions to prevent recurrent cramp.

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  • (PMID = 22420923.001).
  • [ISSN] 1757-1146
  • [Journal-full-title] Journal of foot and ankle research
  • [ISO-abbreviation] J Foot Ankle Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3361473
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2. |||||||||. 89%  Blyton F, Ryan MM, Ouvrier RA, Burns J: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors. Neurology; 2011 Dec 13;77(24):2115-8
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  • [Title] Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • OBJECTIVES: To identify correlates of calf cramp in children with Charcot-Marie-Tooth disease type 1A (CMT1A).
  • Post hoc logistic regression analyses were performed to identify independent predictors of calf cramp.
  • RESULTS: Of the 81 children, 26 (32%) reported calf cramp, and 1 child each reported toe, quadriceps, or arm cramp.
  • Calf cramp was associated (p < 0.05) with older age; the presence of hand tremor; stronger foot inversion, eversion, dorsiflexion, and plantarflexion; and better performance in long-jump and 9-hole peg tests.
  • Logistic regression analysis revealed only increasing age (odds ratio [OR] 1.32, 95% confidence interval [CI] 1.11-1.58; p = 0.002) and the presence of hand tremor (OR 3.81, 95% CI 1.18-12.56; p = 0.028) as independent predictors of calf cramp.
  • CONCLUSION: Calf cramps are common in children with CMT1A and worsen with age.
  • This study revealed a previously unrecognized link between cramp and hand tremor in children with CMT1A.
  • Further investigation of proposed mechanisms and risk factors common to both cramp and tremor will contribute to our understanding of these common complications of CMT1A.
  • [MeSH-major] Charcot-Marie-Tooth Disease / complications. Muscle Cramp / complications


3. |......... 11%  Senapin S, Phiwsaiya K, Gangnonngiw W, Flegel TW: False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia. J Negat Results Biomed; 2011;10:10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia.
  • BACKGROUND: Infectious myonecrosis virus (IMNV) disease outbreaks in cultivated whiteleg shrimp Penaeus (Litopenaeus) vannamei are characterized by gross signs of whitened abdominal muscles and by slow mortality reaching up to 70%.
  • In 2006 the first disease outbreaks caused by IMNV in Asia occurred in Indonesia.
  • Since then rumours have periodically circulated about IMNV disease outbreaks in other Asian countries.
  • In most cases, our shrimp samples for which tissue sections were possible showed signs of muscle cramp syndrome that also commonly causes muscle whitening in stressed whiteleg shrimp.
  • Thus, we suspect that most of the false rumours in Asia about IMNV outside of Indonesia have resulted because of muscle cramp syndrome.
  • We suspect that confusion has arisen because muscle cramp syndrome causes similar signs of whitened tail muscles in whiteleg shrimp.

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  • [Cites] Dis Aquat Organ. 2005 Feb 28;63(2-3):261-5 [15819442.001]
  • [Cites] Dis Aquat Organ. 2007 May 9;75(3):183-90 [17629112.001]
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  • (PMID = 21813002.001).
  • [ISSN] 1477-5751
  • [Journal-full-title] Journal of negative results in biomedicine
  • [ISO-abbreviation] J Negat Results Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC3199911
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Advertisement
4. |......... 7%  Cooper IF, Siadaty MS: 'Intellectual Products' associated with 'Cramp Finding': Top Publications. BioMedLib Review; IntellectualProduct;CrampFinding:706134989. ISSN: 2331-5717. 2014/1/23
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  • [Title] 'Intellectual Products' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Intellectual Product' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Intellectual Product'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 6157 publications.
  • Here are the top 10.
  • Bilbey DL et al: Muscle cramps and magnesium deficiency: case reports.
  • Chiba S et al: Autosomal dominant muscle cramp syndrome in a Japanese family.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Demircan MN et al: Cramp finding: can it be used as a new diagnostic and prognostic factor in lumbar disc surgery?.
  • Cooper IF et al: 'Steroids' associated with 'Cramps Of Lower Extremities': Top Publications.
  • Van den Bergh P et al: Familial muscle cramps with autosomal dominant transmission.
  • Sebo P et al: Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Mohan P et al: Medical image. Recurrent muscle cramps in chronic diarrhoea. Primary intestinal lymphangiectasia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706134989.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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5. |||||||||. 129%  Drouet A: [Management of muscle cramp: what's to be done?]. Rev Prat; 2013 May;63(5):619-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of muscle cramp: what's to be done?].
  • [Transliterated title] Comment optimiser la prise en charge des crampes musculaires?
  • Muscle cramp is characterized by involuntary, painful, visible contraction of a muscle (or a part of muscle) and is always associated with irregular repetitive firing of motor unit action potentials (200 à 300 Hz) which is caused by hyperexcitability of intramuscular terminal motor axons.
  • A careful history and examination should allow the physician to determine the significance of cramp.
  • ENMG and biological tests are needed in cases of severe symptoms (severity and frequency of cramps) and/or abnormal examination.
  • Idiopathic and secondary (drug or metabolic disorders) cramps are the most common groups, but it's very important to search the motor unit diseases (neuropathy, radiculopathy, plexopathy, neuromyotonia, and a cramp fasciculation syndrome which can preceded ALS).
  • The first goal in management of cramp is to determine if there is an underlying cause and the second to use physical measures (stretching), because, pharmacologic treatments have a moderate interest because of the potential of toxicity (quinine sulfate) or a little effectiveness (vitamin B complex, naftidrofuryl, and calcium channel blockers such as diltiazem, gabapentin).
  • Isolated cramp doesn't need treatment.
  • [MeSH-major] Muscle Cramp / therapy

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  • (PMID = 23789484.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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6. |......... 5%  Tayebi Khosroshahi H, Habibi Asl B, Habibzadeh A, Chaichi P, Ghanbarpour A, Hossein Badie A: Comparison of vitamin e and L-carnitine, separately or in combination in patients with intradialytic complications. Nephrourol Mon; 2013 Sep;5(4):862-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The most common complications during dialysis are hypotension and muscle cramps.
  • PATIENTS AND METHODS: In a prospective study, 20 patients with end stage renal disease on chronic hemodialysis that had intradialytic complications such as hypotension, muscle cramp, nausea, vomiting and headache were studied.
  • RESULTS: All three treatments significantly reduced frequency of muscle cramps in comparison to baseline values.
  • Vitamin E alone and in combination with L-carnitine reduced the frequency of muscle cramps more effectively.

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  • (PMID = 24350082.001).
  • [ISSN] 2251-7006
  • [Journal-full-title] Nephro-urology monthly
  • [ISO-abbreviation] Nephrourol Mon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3842554
  • [Keywords] NOTNLM ; Carnitine / Kidney Failure, Chronic / Renal Dialysis / Vitamin E
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7. |......... 6%  Ge HY, Fernández-de-Las-Peñas C, Yue SW: Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation. Chin Med; 2011;6:13
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  • The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity.
  • Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps.

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  • (PMID = 21439050.001).
  • [ISSN] 1749-8546
  • [Journal-full-title] Chinese medicine
  • [ISO-abbreviation] Chin Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3070691
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8. |......... 5%  Suganami A, Sakamoto K, Ono T, Watanabe H, Hijioka N, Murakawa M, Kimura J: The inhibitory effect of shakuyakukanzoto on K+ current in H9c2 cells. Fukushima J Med Sci; 2014;60(1):22-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Shakuyakukanzoto (shao-yao-gan-cao-tang) is a commonly used Chinese traditional herbal medicine for the treatment of acute pain with muscle cramp.
  • This may be a part of the Shakuyakukanzoto mechanism for improving muscle pain.

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  • (PMID = 24670676.001).
  • [ISSN] 2185-4610
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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9. |||||||||. 127%  Okada Y, Ayaki T, Matsumoto R, Ito H, Takahashi R, Nakano S: [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement]. Rinsho Shinkeigaku; 2012;52(10):774-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement].
  • A 53-year-old man presented mild, but gradually worsening, distal-dominant upper bilateral limbs weakness and muscle cramp in both legs from the age of 30.
  • He had no obvious muscle atrophy during the course of the disease.
  • Muscle biopsy of the right lateral vastus muscle showed myopathic changes with round or helical hyaline inclusions in eosinophilic on H&E staining and dark green on modified Gomori trichrome.
  • While MFM patients are sometimes reported to develop serious conditions such as severe weakness, cardiomyopathy or respiratory failure, which require a pacemaker or mechanical ventilator, our case only had mild distal dominant limb weakness and muscle cramps.
  • [MeSH-major] Arrhythmogenic Right Ventricular Dysplasia / complications. Arrhythmogenic Right Ventricular Dysplasia / diagnosis. Muscle Cramp / etiology. Muscle, Skeletal. Muscular Atrophy / etiology
  • [MeSH-minor] Connectin / metabolism. Desmin / metabolism. Diagnosis, Differential. Disease Progression. Extremities. Humans. Immunohistochemistry. Male. Middle Aged

  • Genetic Alliance. consumer health - Distal Myopathy.
  • Genetic Alliance. consumer health - Myofibrillar myopathy.
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  • (PMID = 23064629.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Connectin; 0 / Desmin; 0 / MYOT protein, human; Arrhythmogenic Right Ventricular Dysplasia, Familial, 7
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10. |||||||||. 87%  Miller KC, Knight KL, Wilding SR, Stone MB: Duration of electrically induced muscle cramp increased by increasing stimulation frequency. J Sport Rehabil; 2012 May;21(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • CONTEXT: Electrically induced muscle cramps (EIMC) do not last long enough to study many cramp treatments.
  • Increasing stimulation frequency lengthens cramp duration; it is unknown which frequency elicits the longest EIMC.
  • OBJECTIVE: To determine which stimulation frequency elicits the longest EIMC and whether cramp duration and stimulation frequency are correlated.
  • PARTICIPANTS: 20 participants (12 male, 8 female; age 20.7 ± 0.6 y; height 174.9 ± 1.9 cm; mass 76.6 ± 2.2 kg) with a self-reported history of muscle cramps in their lower extremities within the 6 mo before the study.
  • After 1 min of rest, stimulation frequency increased in 2-Hz increments until a cramp occurred in the flexor hallucis brevis.
  • The stimulation frequency at which a cramp occurred was termed cramp threshold frequency (TF).
  • Cramp duration was determined using strict clinical criteria (loss of hallux rigidity and return of hallux neutral).
  • On the next 4 consecutive days, participants were stimulated at 5, 10, 15, or 20 Hz above TF, and cramp duration was reassessed.
  • MAIN OUTCOME MEASURES: Cramp TF and duration.
  • RESULTS: Cramp TF was 16.9 ± 5.1 Hz.
  • Cramp duration was longer at 15 and 20 Hz above TF (77.9 ± 37.6 s and 69.5 ± 36.9 s, respectively) than at TF (40.8 ± 34.0 s; P < .05).
  • Cramp duration and TF were highly correlated (r = .90).
  • CONCLUSIONS: Stimulating at 15 and 20 Hz above cramp TF produces the longest-lasting EIMC.

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  • (PMID = 22104040.001).
  • [ISSN] 1543-3072
  • [Journal-full-title] Journal of sport rehabilitation
  • [ISO-abbreviation] J Sport Rehabil
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. ||||||||.. 80%  Braulick KW, Miller KC, Albrecht JM, Tucker JM, Deal JE: Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency. Br J Sports Med; 2013 Jul;47(11):710-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency.
  • OBJECTIVE: Many clinicians believe that exercise-associated muscle cramps (EAMC) occur because of dehydration.
  • Mild hypohydration (3% body mass loss) does not alter threshold frequency (TF), a measure of cramp susceptibility, when fatigue and exercise intensity are controlled.
  • Dominant limb flexor hallucis brevis cramp TF, cramp electromyography (EMG) amplitude and cramp intensity were measured in 10 euhydrated, unacclimated men (age=24±4 years, height=184.2±4.8 cm, mass=84.8±11.4 kg).
  • Cramp variables were reassessed posthypohydration.
  • They lost 4.7±0.5% of their body mass (3.9±0.5 litres of fluid), 4.0±1.5 g of Na(+) and 0.6±0.1 g K(+) via exercise-induced sweating.
  • Significant (n=5) or serious hypohydration (n=5) did not alter cramp TF (euhydrated=15±5 Hz, hypohydrated=13±6 Hz; F1,9=3.0, p=0.12), cramp intensity (euhydrated= 94.2±41%, hypohydrated=115.9±73%; F1,9=1.9, p=0.2) or cramp EMG amplitude (euhydrated=0.18±0.06 µV, hypohydrated= 0.18±0.09 µV; F1,9=0.1, p=0.79).
  • CONCLUSIONS: Significant and serious hypohydration with moderate electrolyte losses does not alter cramp susceptibility when fatigue and exercise intensity are controlled.
  • Neuromuscular control may be more important in the onset of muscle cramps than dehydration or electrolyte losses.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Biological Markers / blood. Electromyography. Exercise / physiology. Humans. Male. Muscle Fatigue / physiology. Muscle, Skeletal / physiology. Sweat / chemistry. Young Adult

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  • (PMID = 23222192.001).
  • [ISSN] 1473-0480
  • [Journal-full-title] British journal of sports medicine
  • [ISO-abbreviation] Br J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biological Markers
  • [Keywords] NOTNLM ; Dehydration / Muscle cramping
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12. ||||||.... 59%  Bischoff M: [From muscle cramp to rhabdomyolysis: what is causing muscle pain?]. MMW Fortschr Med; 2012 Oct 4;154(17):26-7
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  • [Title] [From muscle cramp to rhabdomyolysis: what is causing muscle pain?].
  • [MeSH-major] Muscle Cramp / etiology. Pain / etiology. Rhabdomyolysis / etiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Medical History Taking. Muscle Weakness / etiology. Physical Examination

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  • (PMID = 23088029.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] News
  • [Publication-country] Germany
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13. |......... 10%  Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans. Med Sci Sports Exerc; 2010 May;42(5):953-61
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  • [Title] Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • INTRODUCTION: Anecdotal evidence suggests that ingesting small volumes of pickle juice relieves muscle cramps within 35 s of ingestion.
  • No experimental evidence exists supporting the ingestion of pickle juice as a treatment for skeletal muscle cramps.
  • METHODS: On two different days (1 wk apart), muscle cramps were induced in the flexor hallucis brevis (FHB) of hypohydrated male subjects (approximately 3% body weight loss and plasma osmolality approximately 295 mOsm x kg(-1) H2O) via percutaneous tibial nerve stimulation.
  • Thirty minutes later, a second FHB muscle cramp was induced and was followed immediately by the ingestion of 1 mL x kg(-1) body weight of deionized water or pickle juice (73.9 +/- 2.8 mL).
  • RESULTS: Cramp duration and FHB EMG activity during the cramp were quantified, as well as the change in plasma constituents.
  • Cramp duration (water = 151.9 +/- 12.9 s and pickle juice = 153.2 +/- 23.7 s) and FHB EMG activity (water = 60% +/- 6% and pickle juice = 68% +/- 9% of maximum voluntary isometric contraction EMG activity) were similar during the initial cramp induction without fluid ingestion (P > 0.05).
  • During FHB muscle cramp induction combined with fluid ingestion, FHB EMG activity was again similar (water = 55% +/- 9% and pickle juice = 66% +/- 9% of maximum voluntary isometric contraction EMG activity, P > 0.05).
  • However, cramp duration was 49.1 +/- 14.6 s shorter after pickle juice ingestion than water (84.6 +/- 18.5 vs 133.7 +/- 15.9 s, respectively, P < 0.05).
  • CONCLUSIONS: Pickle juice, and not deionized water, inhibits electrically induced muscle cramps in hypohydrated humans.
  • We suspect that the rapid inhibition of the electrically induced cramps reflects a neurally mediated reflex that originates in the oropharyngeal region and acts to inhibit the firing of alpha motor neurons of the cramping muscle.
  • [MeSH-major] Acetic Acid / therapeutic use. Dehydration / complications. Electric Stimulation / adverse effects. Muscle Cramp / etiology. Muscle Cramp / therapy

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  • (PMID = 19997012.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Electrolytes; Q40Q9N063P / Acetic Acid
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14. |......... 9%  Stone MB, Edwards JE, Huxel KC, Cordova ML, Ingersoll CD, Babington JP: Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise. J Sports Sci; 2010 Feb;28(4):399-405
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise.
  • Though clinical observations and laboratory data provide some support for the neuromuscular imbalance theory of the genesis of exercise-associated muscle cramps, no direct evidence has been published.
  • The purpose of this study was to determine the effect of local muscle fatigue on the threshold frequency of an electrically induced muscle cramp.
  • To determine baseline threshold frequency, a cramp was electrically induced in the flexor hallucis brevis of 16 apparently healthy participants (7 males, 9 females; age 25.1 +/- 4.8 years).
  • In the control condition, participants rested in a supine position for 30 min followed by another cramp induction to determine post-threshold frequency.
  • An increase in threshold frequency seems to demonstrate a decrease in one's propensity to cramp following the fatigue exercise regimen used.
  • These results contradict the proposed theory that suggests cramp propensity should increase following fatigue.
  • However, differences in laboratory versus clinical fatiguing exercise and contributions from other sources, as well as the notion of a graded response to fatiguing exercise, on exercise-associated muscle cramp and electrically induced muscle cramp should be considered.
  • [MeSH-major] Exercise / physiology. Muscle Contraction / physiology. Muscle Fatigue / physiology. Muscle, Skeletal / physiology

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  • (PMID = 20131142.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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15. |......... 9%  Hawke F, Chuter V, Burns J: Impact of nocturnal calf cramping on quality of sleep and health-related quality of life. Qual Life Res; 2013 Aug;22(6):1281-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of nocturnal calf cramping on quality of sleep and health-related quality of life.
  • PURPOSE: To evaluate the impact of nocturnal calf cramping (a condition that affects one in two people over 60 years of age) on quality of sleep and health-related quality of life.
  • METHODS: Eighty adults who experienced nocturnal calf cramp at least once per week and eighty age- and sex-matched controls who never experienced nocturnal cramp were recruited from the Greater Newcastle and Central Coast regions of New South Wales, Australia.
  • RESULTS: People who experienced nocturnal muscle cramps reported more sleep disturbance (p < 0.001), less adequate sleep (p = 0.001), less quantity of sleep (p = 0.02) and more snoring (p = 0.03).
  • Both sleep problem summary indices for the MOS-SS identified people who experienced nocturnal muscle cramp as having more sleep problems than the controls.
  • People who experienced nocturnal muscle cramps had lower health-related quality of life for the SF-36 domains role physical (p = 0.007), bodily pain (p = 0.003) and general health (p = 0.02).
  • The impact of nocturnal calf cramps on health-related quality of life was largely explained by their negative impact on quality of sleep.
  • CONCLUSIONS: Nocturnal calf muscle cramps are associated with substantially reduced quality of sleep and reduced physical aspects of health-related quality of life.
  • [MeSH-major] Circadian Rhythm. Health Status. Muscle Cramp / psychology. Quality of Life. Sleep

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  • (PMID = 23011494.001).
  • [ISSN] 1573-2649
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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16. |......... 8%  Zhang WW, Xu ZP, Cui YY, Wang H, Song MK, Li J, Shao BY, Xia Z, Chen HZ: Peripheral cholinoceptor antagonist anisodamine counteracts cholinergic adverse effects and facilitates cognitive amelioration of rivastigmine. J Neural Transm; 2009 Dec;116(12):1643-9
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  • Rivastigmine is a potent acetyl- and butyrylcholinesterase inhibitor widely used for cognitive improvement in Alzheimer's disease (AD) therapy.
  • Nevertheless, a high dose of rivastigmine (3.25 mg/kg) would compromise cognitive amelioration and produce obvious adverse effects, including hypersalivation, intestinal hyperperistalsis and muscle cramp.
  • [MeSH-minor] Animals. Avoidance Learning / drug effects. Cognition / drug effects. Drug Therapy, Combination. Intestines / drug effects. Intestines / physiology. Male. Mice. Mice, Inbred Strains. Muscle Cramp / chemically induced. Muscle Cramp / drug therapy. Random Allocation. Salivation / drug effects. Scopolamine Hydrobromide

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  • (PMID = 19756370.001).
  • [ISSN] 1435-1463
  • [Journal-full-title] Journal of neural transmission (Vienna, Austria : 1996)
  • [ISO-abbreviation] J Neural Transm
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Cholinergic Antagonists; 0 / Neuroprotective Agents; 0 / Phenylcarbamates; 0 / Solanaceous Alkaloids; 01343Q8EL8 / anisodamine; 123441-03-2 / rivastigmine; 451IFR0GXB / Scopolamine Hydrobromide
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17. |......... 8%  Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Med Sci Sports Exerc; 2010 Nov;42(11):2056-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • PURPOSE: Dehydration is hypothesized to cause exercise-associated muscle cramps.
  • The theory states that dehydration contracts the interstitial space, thereby increasing the pressure on nerve terminals and cramps ensue.
  • Inducing cramps with electrical stimulation minimizes many of the confounding factors associated with exercise-induced cramps (e.g., fatigue, metabolites).
  • Thus, our goal was to minimize fatigue and determine whether hypohydration decreases the electrical stimuli required to elicit cramping (termed "threshold frequency").
  • Dominant leg flexor hallucis brevis muscle cramps were induced before and after hypohydration, and threshold frequency was recorded.
  • CONCLUSIONS: Mild hypohydration with minimal neuromuscular fatigue does not seem to predispose individuals to cramping.
  • Thus, cramps may be more associated with neuromuscular fatigue than dehydration/electrolyte losses.
  • Health care professionals may have more success preventing exercise-associated muscle cramp by focusing on strategies that minimize neuromuscular fatigue rather than dehydration.
  • However, the effect of greater fluid losses on cramp threshold frequency is unknown and merits further research.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology. Muscle Fatigue

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  • (PMID = 20351595.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. |......... 8%  Hung CY, Chen YL, Chen CS, Yang CS, Peng SJ: Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study. Blood Purif; 2009;27(2):159-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study.
  • BACKGROUND/AIMS: The mechanism of muscle cramp in hemodialysis patients is not well understood.
  • This study aimed to determine the association between leptin and hemodialysis-related muscle cramps.
  • The episodes of hemodialysis-related muscle cramps were recorded over a 28-day period.
  • RESULTS: Frequent hemodialysis-related cramps were associated with old age and elevated serum leptin levels.
  • The risk of frequent hemodialysis-related cramps increased with increasing tertiles of leptin concentration.
  • This relationship remained significant after adjustment for age, mean ultrafiltration ratio, gender, body mass index, insulin, resistin, c-reactive protein, albumin, peripheral arterial disease, electrolytes, and beta(2)-microglobulin.
  • CONCLUSION: Leptin levels are associated with frequent hemodialysis-related cramps.
  • [MeSH-major] Kidney Failure, Chronic / complications. Leptin / blood. Muscle Cramp / etiology. Renal Dialysis / adverse effects


19. |......... 8%  Blyton F, Chuter V, Walter KE, Burns J: Non-drug therapies for lower limb muscle cramps. Cochrane Database Syst Rev; 2012;1:CD008496
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  • [Title] Non-drug therapies for lower limb muscle cramps.
  • BACKGROUND: About one in every three adults are affected by lower limb muscle cramps.
  • For some people, these cramps reduce quality of life, quality of sleep and participation in activities of daily living.
  • Many interventions are available for lower limb cramps, but some are controversial, no treatment guidelines exist, and often people experience no benefit from the interventions prescribed.
  • OBJECTIVES: To assess the effects of non-drug, non-invasive treatments for lower limb cramp.
  • SEARCH METHODS: We searched the Cochrane Neuromuscular Disease Group Specialized Register (13 September 2011) using the terms: cramp, spasm, contracture, charley horse and lower limb, lower extremity, foot, calf, leg, thigh, gastrocnemius, hamstring, quadriceps.
  • SELECTION CRITERIA: All randomised controlled trials of non-drug, non-invasive interventions trialled over at least four weeks for the prevention of lower limb muscle cramps in any group of people.
  • We selected only trials that included at least one of the following outcomes: cramp frequency, cramp severity, health-related quality of life, quality of sleep, participation in activities of daily living and adverse outcomes.
  •  All participants were age 60 years or over and had received a repeat prescription from their general practitioner of quinine for nighttime cramps in the preceding three months.
  • Forty-nine participants were advised to complete lean-to-wall calf muscle stretching held for 10 s three times per day.
  • After 12 weeks, there was no statistically significant difference in recalled cramp frequency between groups.
  • AUTHORS' CONCLUSIONS: There is limited evidence on which to base clinical decisions regarding the use of non-drug therapies for the treatment of lower limb muscle cramp.
  • [MeSH-major] Lower Extremity. Muscle Cramp / therapy. Muscle Stretching Exercises / methods
  • [MeSH-minor] Aged. Humans. Middle Aged. Muscle Relaxants, Central / therapeutic use. Quinine / therapeutic use. Randomized Controlled Trials as Topic

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  • (PMID = 22258986.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscle Relaxants, Central; A7V27PHC7A / Quinine
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20. |......... 7%  Hokari S, Koya T, Shimaoka Y, Nakayama H, Terada M, Suzuki E: [Interstitial pneumonia associated with stiff-person syndrome]. Nihon Kokyuki Gakkai Zasshi; 2010 Feb;48(2):162-5
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  • Three months after the diagnosis of interstitial pneumonia, he noticed neurological symptoms, such as facial spasms, dysphagia, muscle rigidity and muscle cramp, and repeatedly received clonazepam.

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  • (PMID = 20184250.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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21. |......... 7%  Ge HY, Arendt-Nielsen L: Latent myofascial trigger points. Curr Pain Headache Rep; 2011 Oct;15(5):386-92
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  • A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination.
  • Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle fiber contraction and/or muscle cramp potentials, which contribute significantly to the induction of local tenderness and pain and motor dysfunctions.

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  • (PMID = 21559783.001).
  • [ISSN] 1534-3081
  • [Journal-full-title] Current pain and headache reports
  • [ISO-abbreviation] Curr Pain Headache Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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22. |......... 7%  Najafi L, Khamseh ME, Malek M, Baradaran HR, Aghili SM, Kia M, Aghili R: Rapid screening of diabetic polyneuropathy: selection of accurate symptoms and signs in an outpatient clinical setting. Acta Med Iran; 2014;52(7):519-27
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  • In patients' history, the most sensitive (99.4%) and accurate (78%) symptoms were muscle cramp and weakness.
  • Findings show that symptoms such as a muscle cramp, weakness, numbness, and prickling, as well as signs such as ankle reflexes, appearance of feet, and vibration could be used as the most accurate tests for rapid diagnosis of DPN.

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  • (PMID = 25135261.001).
  • [ISSN] 1735-9694
  • [Journal-full-title] Acta medica Iranica
  • [ISO-abbreviation] Acta Med Iran
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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23. |......... 7%  Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Cramp Finding': Top Publications. BioMedLib Review; DiseaseOrSyndrome;CrampFinding:705073935. ISSN: 2331-5717. 2014/7/5
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  • [Title] 'Diseases or Syndromes' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 27 publications, and group two 1397 publications.
  • Here are the top 10.
  • Allen RE et al: Nocturnal leg cramps.
  • Ohtori S et al: Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • : Information from your family doctor. Nocturnal leg cramps.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Westwood AJ et al: CPAP treats muscle cramps in patients with obstructive sleep apnea.
  • Rana AQ et al: Differentiating nocturnal leg cramps and restless legs syndrome.
  • Atluri DK et al: An alternative treatment for muscle cramps in patients with liver cirrhosis.
  • Ditch SM et al: A college student with muscle cramps and weakness. Diagnosis: Bulimia nervosa, purging subtype, complicated by rhabdomyolysis and acute renal failure.
  • Okada Y et al: [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705073935.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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24. |......... 6%  Liu SL, Chen G, Zhao YP, Wu WM, Zhang TP: Optimized dose of imatinib for treatment of gastrointestinal stromal tumors: a meta-analysis. J Dig Dis; 2013 Jan;14(1):16-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The rates of rash, hemorrhage, nausea, vomiting and taste disturbance increased as dose increased (P < 0.05), whereas the incidence of headache, abdominal pain, edema, fatigue, anemia, infection, muscle cramp and constipation was nearly identical and showed no significant difference.

  • Genetic Alliance. consumer health - Gastrointestinal Stromal Tumors.
  • HSDB. structure - IMATINIB MESYLATE.
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  • [Copyright] © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
  • (PMID = 23121684.001).
  • [ISSN] 1751-2980
  • [Journal-full-title] Journal of digestive diseases
  • [ISO-abbreviation] J Dig Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; BKJ8M8G5HI / imatinib
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25. |......... 6%  Arimura K, Watanabe O: [Immune-mediated neuromyotonia (Isaacs' syndrome)--clinical aspects and pathomechanism]. Brain Nerve; 2010 Apr;62(4):401-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Isaacs' syndrome (immune-mediated neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy).
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction (pseudomyotonia), and hyperhidrosis; these symptoms are due to hyperexcitability of the peripheral nerve, including autonomic nerve.
  • Recent studies show that this disease is not infrequently associated with neoplasm, especially thymoma.

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  • (PMID = 20420181.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Potassium Channels; 0 / Potassium Channels, Voltage-Gated
  • [Number-of-references] 32
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26. |......... 6%  Miller KC, Burne JA: Golgi tendon organ reflex inhibition following manually applied acute static stretching. J Sports Sci; 2014;32(15):1491-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Golgi tendon organ disinhibition may contribute to exercise-associated muscle cramp (henceforth referred to as "cramps") genesis.
  • Static stretching pre-exercise is prescribed to prevent cramps based on the assumption golgi tendon organ inhibition remains elevated post-stretching.
  • If pre-stretching does prevent fatigue-induced cramping, the mechanism is unlikely to involve the autoinhibition produced by the golgi tendon organ reflex.
  • Further empirical research is needed to validate the proposed link between static stretching and cramping and then to investigate alternative mechanisms.

  • ResearchGate. author profiles.
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  • (PMID = 24716521.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; alpha motor neuron / electrical stimulation / muscle cramp / tendon afferents
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27. |......... 6%  Takashima H: [History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)]. Rinsho Shinkeigaku; 2013;53(11):1196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan.
  • This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484).
  • Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required.
  • Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA).
  • Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time.

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  • (PMID = 24291927.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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28. |......... 6%  Watanabe O: [Isaacs's syndrome and associated diseases]. Rinsho Shinkeigaku; 2013;53(11):1067-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Isaacs' syndrome is an antibody-mediated potassium channel disorder.
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction, and hyperhidrosis.

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  • (PMID = 24291881.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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29. |......... 6%  Hara K, Watanabe O, Shibano K, Ishiguro H: [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity]. Rinsho Shinkeigaku; 2012;52(9):677-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity].
  • A 21-year-old man complained of severe pain and muscle twitching localized in his right arm.
  • Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia.
  • Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges.
  • This case with neither muscle cramp nor myokymia expands the phenotype of anti VGKC-complex antibody associated disorder.

  • MedlinePlus Health Information. consumer health - Pain.
  • HSDB. structure - METHYLPREDNISOLONE.
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  • (PMID = 22989904.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biological Markers; 0 / Immunoglobulins, Intravenous; 0 / Potassium Channels, Voltage-Gated; X4W7ZR7023 / Methylprednisolone
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30. |......... 5%  Ichikawa T, Naota T, Miyaaki H, Miuma S, Isomoto H, Takeshima F, Nakao K: Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance. Hepatol Res; 2010 Oct;40(10):971-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The items, as major symptoms of cirrhotic patients, were as follows: hand tremor, appetite loss, muscle cramp of foot, fatigue, decreased strength, anxiety, abdominal fullness, abdominal pain and a feeling of low energy.
  • However, the cirrhotic symptom-related score was positively relation with the Child-Pugh score at the time of patient entry, and we were unable to identify the item that related to ESS.

  • ResearchGate. author profiles.
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  • [Copyright] © 2010 The Japan Society of Hepatology.
  • (PMID = 20887332.001).
  • [ISSN] 1386-6346
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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31. |......... 5%  Kim HJ, Kim CK, Carpentier A, Poortmans JR: Studies on the safety of creatine supplementation. Amino Acids; 2011 May;40(5):1409-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Anecdotal reports from athletes have appeared on muscle cramp and gastrointestinal complaints during creatine supplementation, but the incidence of these is limited and not necessarily linked to creatine itself.
  • We advise that high-dose (>3-5 g/day) creatine supplementation should not be used by individuals with pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate).

  • MedlinePlus Health Information. consumer health - Kidney Diseases.
  • HSDB. structure - CREATINE.
  • ResearchGate. author profiles.
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  • (PMID = 21399917.001).
  • [ISSN] 1438-2199
  • [Journal-full-title] Amino acids
  • [ISO-abbreviation] Amino Acids
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] MU72812GK0 / Creatine
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32. |......... 5%  Cooper IF, Siadaty MS: 'Qualitative Concepts' associated with 'Cramp Finding': Top Publications. BioMedLib Review; QualitativeConcept;CrampFinding:706475404. ISSN: 2331-5717. 2014/1/27
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  • [Title] 'Qualitative Concepts' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Qualitative Concept' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Qualitative Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 12 publications, and group two 691 publications.
  • Here are the top 7.
  • Cooper IF et al: 'Steroids' associated with 'Cramp Finding': Top Publications.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Braulick KW et al: Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency.
  • Hawke F et al: Factors associated with night-time calf muscle cramps: a case-control study.
  • Lee KK et al: Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
  • Sato A et al: [An autopsy case of amyotrophic lateral sclerosis with prominent muscle cramps, fasciculation, and high titer of anti-voltage gated potassium channel (VGKC) complex antibody].
  • Rana AQ et al: Differentiating nocturnal leg cramps and restless legs syndrome.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706475404.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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33. |......... 5%  Cooper IF, Siadaty MS: 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications. BioMedLib Review; NaturalPhenomenonOr;CrampFinding:706151289. ISSN: 2331-5717. 2014/11/23
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  • [Title] 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Natural Phenomenon or Process' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Natural Phenomenon or Process'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 15 publications, and group two 2827 publications.
  • Here are the top 9.
  • Miller KC et al: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • Serrao M et al: Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps.
  • Merletti R et al: Spinal involvement and muscle cramps in electrically elicited muscle contractions.
  • Miller KC et al: Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Nilsson SE: [Electromagnetic therapy in restless legs syndrome and nocturnal leg muscle cramps. Same effect of pulsating electromagnetic fields and placebo].
  • Miller KC et al: Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • TILLE D: [Initial fever cramps and the weather].
  • Minetto MA et al: Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706151289.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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34. |......... 5%  Cooper IF, Siadaty MS: 'Conceptual Entities' associated with 'Cramp Finding': Top Publications. BioMedLib Review; ConceptualEntity;CrampFinding:706125817. ISSN: 2331-5717. 2014/10/23
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  • [Title] 'Conceptual Entities' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Conceptual Entity' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Conceptual Entity'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 17 publications, and group two 5507 publications.
  • Here are the top 10.
  • Ahsan M et al: Prevention of hemodialysis-related muscle cramps by intradialytic use of sequential compression devices: a report of four cases.
  • Minaker KL et al: Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy.
  • Kaji DM et al: Prevention of muscle cramps in haemodialysis patients by quinine sulphate.
  • Steurer J: [Quinine is effective in prevention of muscle cramps].
  • Guay DR: Are there alternatives to the use of quinine to treat nocturnal leg cramps?.
  • Atluri DK et al: An alternative treatment for muscle cramps in patients with liver cirrhosis.
  • Miller JM: A simple alternative to quinine for nocturnal muscle cramps.
  • : [Experimental studies on prevention of muscular cramps caused by 2 F-type schistosomicides].
  • ARNONE G: [Radiography of an influenzal thoracic localization cured by antibiotics; mediastinal adenopathy; antibiotics and the autonomic nervous system; pulmonary and muscular cramp; infarct; bilateral atelectasis; interstitial pulmonitis; hepatitis and recovery].
  • Tonsa A: [Prevention of succinylcholine-induced muscle cramp with Diazepam].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706125817.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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35. |......... 5%  Cooper IF, Siadaty MS: 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Cramp Finding': Top Publications. BioMedLib Review; BodyPartOrgan;CrampFinding:706324818. ISSN: 2331-5717. 2014/8/25
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  • [Title] 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Body Part Organ or Organ Component' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Body Part Organ or Organ Component'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 23 publications, and group two 5349 publications.
  • Here are the top 10.
  • Minetto MA et al: Discharge properties of motor units of the abductor hallucis muscle during cramp contractions.
  • Demircan MN et al: Cramp finding: can it be used as a new diagnostic and prognostic factor in lumbar disc surgery?.
  • Woloson SK et al: Superficial femoral artery branch avulsion after severe muscle cramping.
  • Minetto MA et al: Elicitability of muscle cramps in different leg and foot muscles.
  • Blyton F et al: Non-drug therapies for lower limb muscle cramps.
  • Ross BH et al: Human motor unit activity during induced muscle cramp.
  • Khokhlov AM et al: [Role of electrolytes in the pathogenesis of arterial spasm and muscle cramps in varicose veins of the lower limbs].
  • Kanai K et al: Motor nerve hyperexcitability and muscle cramps in Machado-Joseph disease.
  • Mohan P et al: Medical image. Recurrent muscle cramps in chronic diarrhoea. Primary intestinal lymphangiectasia.
  • Layzer RB: Leg muscle cramps.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706324818.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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36. |......... 5%  Cooper IF, Siadaty MS: 'Ideas or Concepts' associated with 'Cramp Finding': Top Publications. BioMedLib Review; IdeaOrConcept;CrampFinding:707326245. ISSN: 2331-5717. 2014/2/8
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  • [Title] 'Ideas or Concepts' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Idea or Concept' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Idea or Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 26 publications, and group two 4817 publications.
  • Here are the top 10.
  • Janssen M et al: Muscle cramps in the calf as presenting symptom of sarcoidosis.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Cooper IF et al: 'Functional Concepts' associated with 'Cramps Of Lower Extremities': Top Publications.
  • Créange A et al: A patient with one limb interstitial myositis with localised lipoatrophy presenting with severe cramps and fasciculations.
  • Leung AK et al: Ureteral calculus presenting as generalized abdominal cramps.
  • Motoo Y et al: Effect of niuche-shen-qi-wan on painful muscle cramps in patients with liver cirrhosis: a preliminary report.
  • Rosen JM et al: Spasmodic muscle cramps and weakness as presenting symptoms in Wilson disease.
  • Dalbo VJ et al: Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration.
  • Krampitz DE et al: Charcot-Marie-Tooth disease type 1A presenting as calf hypertrophy and muscle cramps.
  • Schwellnus MP et al: Aetiology of skeletal muscle 'cramps' during exercise: a novel hypothesis.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707326245.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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37. |......... 5%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Cramp Finding': Top Publications. BioMedLib Review; OrganicChemical;CrampFinding:707361549. ISSN: 2331-5717. 2014/3/9
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  • [Title] 'Organic Chemicals' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organic Chemical' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organic Chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 40 publications, and group two 3281 publications.
  • Here are the top 10.
  • Zekri JM et al: Relative hypocalcaemia and muscle cramps in patients receiving imatinib for gastrointestinal stromal tumour.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • Fernández-Díaz A et al: [Muscle cramps and myalgia related to zolmitriptan].
  • Cooper IF et al: 'Vitamins' associated with 'Cramp Finding': Top Publications.
  • Khajehdehi P et al: A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps.
  • Chang CT et al: Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis.
  • van Kan HJ et al: Hydroquinine pharmacokinetics after oral administration in adult patients with muscle cramps.
  • Serrao M et al: Gabapentin treatment for muscle cramps: an open-label trial.
  • Hinoshita F et al: Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku-kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study.
  • Weber M et al: Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707361549.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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38. |......... 5%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Cramp Finding': Top Publications. BioMedLib Review; Tissue;CrampFinding:707469332. ISSN: 2331-5717. 2014/3/14
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  • [Title] 'Tissues' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Tissue' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Tissue'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 35 publications, and group two 878 publications.
  • Here are the top 10.
  • Oguma S et al: Biotin ameliorates muscle cramps of hemodialysis patients: a prospective trial.
  • Chatrath H et al: Prevalence and morbidity associated with muscle cramps in patients with cirrhosis.
  • Fat MJ et al: Neurologist practice patterns in treatment of muscle cramps in Canada.
  • Abe K: A Patient Developed Painful Muscle Cramps due to Overeating Mangos.
  • Kraus PD et al: Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Mehta SS et al: Muscle cramps in liver disease.
  • Vidot H et al: Systematic review: the treatment of muscle cramps in patients with cirrhosis.
  • Westwood AJ et al: CPAP treats muscle cramps in patients with obstructive sleep apnea.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707469332.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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39. |......... 5%  Cooper IF, Siadaty MS: 'Spatial Concepts' associated with 'Cramp Finding': Top Publications. BioMedLib Review; SpatialConcept;CrampFinding:707393483. ISSN: 2331-5717. 2014/1/9
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  • [Title] 'Spatial Concepts' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Spatial Concept' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Spatial Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 35 publications, and group two 3408 publications.
  • Here are the top 10.
  • Fat MJ et al: Neurologist practice patterns in treatment of muscle cramps in Canada.
  • Leung AK et al: Ureteral calculus presenting as generalized abdominal cramps.
  • Ohtori S et al: Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.
  • Roeleveld K et al: Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics.
  • Li H et al: Cell polarity: stretching prevents developmental cramps.
  • Dickhuth HH et al: Exercise-induced, persistent and generalized muscle cramps. A case report.
  • Hung CY et al: Association of leptin with hemodialysis-related muscle cramps: a cross-sectional study.
  • Lee KK et al: Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
  • Merletti R et al: Spinal involvement and muscle cramps in electrically elicited muscle contractions.
  • Jansen PH et al: Diagnosis and differential diagnosis of muscle cramps: a clinical approach.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707393483.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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40. |......... 5%  Cooper IF, Siadaty MS: 'Amino AcidsCMMA PeptidesCMMA or Proteins' associated with 'Cramp Finding': Top Publications. BioMedLib Review; AminoAcidPeptide;CrampFinding:706119510. ISSN: 2331-5717. 2014/4/23
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  • [Title] 'Amino AcidsCMMA PeptidesCMMA or Proteins' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Amino Acid Peptide or Protein' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Amino Acid Peptide or Protein'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 18 publications, and group two 5095 publications.
  • Here are the top 10.
  • Filosto M et al: Axillary injection of botulinum A toxin in a patient with muscle cramps associated with severe axillary hyperhidrosis.
  • Bertolasi L et al: Botulinum toxin treatment of muscle cramps: a clinical and neurophysiological study.
  • Yamamoto S et al: [Painful muscle cramps in liver cirrhosis and effects of oral taurine administration].
  • Mattana J et al: Muscle cramps and creatine kinase elevations in hemodialysis patients.
  • Whittaker RG et al: Teaching Video NeuroImages: Muscle cramps and a raised creatine kinase.
  • Matsuzaki Y et al: Is taurine effective for treatment of painful muscle cramps in liver cirrhosis?.
  • Ono Y: [A case of 17 alpha-hydroxylase deficiency with long stature and epileptic cramps (author's transl)].
  • Luigetti M et al: Muscle cramps and weakness after teriparatide therapy: a new drug-induced myopathy?.
  • Kakaria PJ et al: Debilitating muscle cramps after teriparatide therapy.
  • Obi T et al: Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706119510.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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41. |......... 4%  Leong D, Vaz Pardal C, Tan B, Lin C: Injury and illness patterns in competitive sailors of the 43rd isaf youth sailing world championship - a 12-month retrospective study. Br J Sports Med; 2014 Apr;48(7):625
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The top 3 injury types were sprain (21%), muscle strain/tear (16%), and muscle cramp/spasm (16%).
  • Of the nine illnesses, sunburn was the most common symptom (29%) and the dermatological system was most commonly affected (44%).

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  • (PMID = 24620218.001).
  • [ISSN] 1473-0480
  • [Journal-full-title] British journal of sports medicine
  • [ISO-abbreviation] Br J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. |......... 4%  Cooper IF, Siadaty MS: 'Population Groups' associated with 'Cramp Finding': Top Publications. BioMedLib Review; PopulationGroup;CrampFinding:706428418. ISSN: 2331-5717. 2014/3/27
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  • [Title] 'Population Groups' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Population Group' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Population Group'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 3018 publications.
  • Here are the top 10.
  • Butler JV et al: Nocturnal leg cramps in older people.
  • Chiba S et al: Autosomal dominant muscle cramp syndrome in a Japanese family.
  • Centers for Disease Control and Prevention (CDC): Adult lead poisoning from an Asian remedy for menstrual cramps--Connecticut, 1997.
  • Man-Son-Hing M et al: Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people.
  • Atreja A et al: A 51-year-old woman with debilitating cramps 12 years after bariatric surgery.
  • Katzberg HD et al: Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology.
  • Naylor JR et al: A general population survey of rest cramps.
  • Schwellnus MP et al: Increased running speed and pre-race muscle damage as risk factors for exercise-associated muscle cramps in a 56 km ultra-marathon: a prospective cohort study.
  • Rison RA: Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
  • Mahajan S et al: Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706428418.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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43. |......... 4%  Cooper IF, Siadaty MS: 'Signs or Symptoms' associated with 'Night Treatment': Top Publications. BioMedLib Review; SignOrSymptom;NightTreatment:706202718. ISSN: 2331-5717. 2014/2/24
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  • [Title] 'Signs or Symptoms' associated with 'Night Treatment': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Sign or Symptom' for 'night treatment'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Sign or Symptom'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 13 publications, and group two 8008 publications.
  • Here are the top 7.
  • Fares A: Night-time exogenous melatonin administration may be a beneficial treatment for sleeping disorders in beta blocker patients.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • López-Alvarenga JC et al: Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group.
  • Naess K: [Angina pectoris. Treatment of night attack].
  • Heber KR: The hormonal treatment of acroparaesthesia and night cramps.
  • Prior JC et al: Progesterone for hot flush and night sweat treatment--effectiveness for severe vasomotor symptoms and lack of withdrawal rebound.
  • Norton S et al: Cognitive-behavior therapy for menopausal symptoms (hot flushes and night sweats): moderators and mediators of treatment effects.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706202718.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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44. |......... 4%  Cooper IF, Siadaty MS: 'Tissues' associated with 'Fasciculation': Top Publications. BioMedLib Review; Tissue;Fasciculation:707425589. ISSN: 2331-5717. 2014/9/10
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  • [Title] 'Tissues' associated with 'Fasciculation': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Tissue' for 'fasciculation'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Tissue'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 28 publications, and group two 1823 publications.
  • Here are the top 10.
  • Yun MJ et al: Remifentanil attenuates muscle fasciculations by succinylcholine.
  • Milner LD et al: Selective fasciculation and divergent pathfinding decisions of embryonic chick motor axons projecting to fast and slow muscle regions.
  • Murata J et al: Central inhibition of the aortic baroreceptors-heart rate reflex at the onset of spontaneous muscle contraction.
  • Bak M et al: Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles.
  • Rico-Santos M et al: [The value of ultrasounds in the detection of muscle fasciculation].
  • Schmitz C et al: The Fat-like cadherin CDH-4 controls axon fasciculation, cell migration and hypodermis and pharynx development in Caenorhabditis elegans.
  • Vos PE et al: [Muscle cramps and fasciculations not always ominous: muscle cramp-fasciculation syndrome].
  • Walker FO et al: Sonographic imaging of muscle contraction and fasciculations: a correlation with electromyography.
  • Layzer RB: The origin of muscle fasciculations and cramps.
  • Randell T et al: Isoflurane inhibits muscle fasciculations caused by succinylcholine in children.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707425589.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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45. |......... 4%  Cooper IF, Siadaty MS: 'Signs or Symptoms' associated with '1 Methyl 2 2 6 Xylyloxy Ethylamine': Top Publications. BioMedLib Review; SignOrSymptom;1Methyl2:705234934. ISSN: 2331-5717. 2014/10/11
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  • [Title] 'Signs or Symptoms' associated with '1 Methyl 2 2 6 Xylyloxy Ethylamine': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Sign or Symptom' for '1 methyl 2 2 6 xylyloxy ethylamine'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Sign or Symptom'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 37 publications, and group two 793 publications.
  • Here are the top 10.
  • Statland JM et al: Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
  • Kamei J et al: Effect of mexiletine on thermal allodynia and hyperalgesia in diabetic mice.
  • Okada S et al: Two cases of multiple sclerosis with painful tonic seizures and dysesthesia ameliorated by the administration of mexiletine.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • Nishiyama K et al: Mexiletine for painful alcoholic neuropathy.
  • Egashira N et al: Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.
  • Kuwabara S et al: The effects of mexiletine on excitability properties of human median motor axons.
  • Kamei J et al: Effect of mexiletine on vincristine-induced painful neuropathy in mice.
  • Marmura MJ: Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.
  • Stracke H et al: [Mexiletine in treatment of painful diabetic neuropathy].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705234934.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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46. |......... 4%  Cooper IF, Siadaty MS: 'Signs or Symptoms' associated with 'Ko 1173': Top Publications. BioMedLib Review; SignOrSymptom;Ko1173:705234891. ISSN: 2331-5717. 2014/4/11
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  • [Title] 'Signs or Symptoms' associated with 'Ko 1173': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Sign or Symptom' for 'ko 1173'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Sign or Symptom'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 37 publications, and group two 838 publications.
  • Here are the top 10.
  • Kamei J et al: Effect of mexiletine on thermal allodynia and hyperalgesia in diabetic mice.
  • Okada S et al: Two cases of multiple sclerosis with painful tonic seizures and dysesthesia ameliorated by the administration of mexiletine.
  • Statland JM et al: Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
  • Nishiyama K et al: Mexiletine for painful alcoholic neuropathy.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • Egashira N et al: Mexiletine reverses oxaliplatin-induced neuropathic pain in rats.
  • Marmura MJ: Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias.
  • Awerbuch GI et al: Mexiletine for thalamic pain syndrome.
  • Kuwabara S et al: The effects of mexiletine on excitability properties of human median motor axons.
  • Stracke H et al: [Mexiletine in treatment of painful diabetic neuropathy].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705234891.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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47. |......... 4%  Reichel G: [Muscle cramps--differential diagnosis and therapy]. Med Monatsschr Pharm; 2009 Mar;32(3):80-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Muscle cramps--differential diagnosis and therapy].
  • Calf cramps are sudden, involuntary, painful contractions of part of or the entire calf muscle that are visible, persist for seconds to minutes and then spontaneously resolve.
  • They can occur with no identifiable cause, and are then referred to as common calf cramps.
  • They may also be symptoms associated with diseases of the peripheral and central nervous system and muscle diseases.
  • In such cases the cramps are more extensive, intense and persist for longer.
  • Cramp-fasciculation-myalgia syndrome additionally involves paresthesias and other signs of hyperexcitability of peripheral nerves.
  • The recommended treatment for patients with frequent calf cramps causing significant impairment of well-being is oral administration of quinidine and/or botulinum toxin treatment of the calf muscles.
  • [MeSH-major] Muscle Cramp / diagnosis. Muscle Cramp / therapy

  • MedlinePlus Health Information. consumer health - Muscle Cramps.
  • ExactAntigen/Labome. author profiles.
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  • (PMID = 19402333.001).
  • [ISSN] 0342-9601
  • [Journal-full-title] Medizinische Monatsschrift für Pharmazeuten
  • [ISO-abbreviation] Med Monatsschr Pharm
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 27
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48. |......... 4%  Diener HC, Westphal K: [Differential diagnosis and treatment of cramps]. MMW Fortschr Med; 2013 Oct 10;155 Suppl 3:83-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Differential diagnosis and treatment of cramps].
  • [Transliterated title] Differenzialdiagnose und Therapie von Muskelkrämpfen (Crampi).
  • Cramps are painful sensations caused by intense involuntary contractions of skeletal muscles, mostly in the calves, usually lasting from a few seconds to several minutes.
  • Although cramps are mostly idiopathic, theycan bea symptom of other forms of myalgia, restless legs syndrome or spasticity.
  • Especially nocturnal cramps can cause considerable distress for patients requiring fast pain reduction and effective prophylaxis.
  • Stretching the calf muscles helps preventing nocturnal cramps.
  • Pharmacological treatment of leg cramps includes magnesium and quinine.
  • [MeSH-major] Muscle Cramp / etiology. Muscle Cramp / therapy
  • [MeSH-minor] Adult. Aged. Analgesics, Non-Narcotic / adverse effects. Analgesics, Non-Narcotic / therapeutic use. Diagnosis, Differential. Female. Humans. Magnesium / adverse effects. Magnesium / therapeutic use. Male. Middle Aged. Muscle Stretching Exercises. Polysomnography. Pregnancy. Quinine / adverse effects. Quinine / therapeutic use. Randomized Controlled Trials as Topic. Sleep Disorders / diagnosis. Sleep Disorders / etiology. Sleep Disorders / therapy

  • MedlinePlus Health Information. consumer health - Muscle Cramps.
  • HSDB. structure - QUININE.
  • HSDB. structure - MAGNESIUM, ELEMENTAL.
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  • (PMID = 24930318.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Analgesics, Non-Narcotic; A7V27PHC7A / Quinine; I38ZP9992A / Magnesium
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49. |......... 4%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Muscle Properties': Top Publications. BioMedLib Review; OrganicChemical;MuscleProperties:705638735. ISSN: 2331-5717. 2014/4/25
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  • [Title] 'Organic Chemicals' associated with 'Muscle Properties': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'organic chemical' for 'muscle properties'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'organic chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 40 publications, and group two 14667 publications.
  • Here are the top 10.
  • Karges K et al: Effects of supplemental vitamin D3 on feed intake, carcass characteristics, tenderness, and muscle properties of beef steers.
  • Coombes JS et al: Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties.
  • Shapiro BP et al: Advanced glycation end products accumulate in vascular smooth muscle and modify vascular but not ventricular properties in elderly hypertensive canines.
  • Mendelev NN et al: Antigrowth properties of BAY 41-2272 in vascular smooth muscle cells.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • Tan Y et al: Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxide.
  • Swieca A et al: AMP-deaminase from hen stomach smooth muscle--physico-chemical properties of the enzyme.
  • Wagner H et al: Biomechanical muscle properties and angiotensin-converting enzyme gene polymorphism: a model-based study.
  • Chabas JF et al: FK506 induces changes in muscle properties and promotes metabosensitive nerve fiber regeneration.
  • Treves S et al: Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705638735.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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50. |......... 4%  Cooper IF, Siadaty MS: 'Genes or Genomes' associated with 'Entire Temporalis Muscle': Top Publications. BioMedLib Review; GeneOrGenome;EntireTemporalisMuscle:705340225. ISSN: 2331-5717. 2014/5/7
PDF icon [Fulltext service] Download fulltext PDF of this article.

  • [Title] 'Genes or Genomes' associated with 'Entire Temporalis Muscle': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Gene or Genome' for 'entire temporalis muscle'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Gene or Genome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 33 publications, and group two 8641 publications.
  • Here are the top 10.
  • Pabelick CM et al: Invited review: significance of spatial and temporal heterogeneity of calcium transients in smooth muscle.
  • Kovac JR et al: Temporal and spatial dynamics underlying capacitative calcium entry in human colonic smooth muscle.
  • Roeleveld K et al: Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics.
  • Tolić-Nørrelykke IM et al: Spatial and temporal traction response in human airway smooth muscle cells.
  • Jakhesara SJ et al: Tissue-specific temporal exome capture revealed muscle-specific genes and SNPs in Indian buffalo (Bubalus bubalis).
  • Kugler JE et al: Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis.
  • Cooper IF et al: 'Temporal Concepts' associated with 'Calponin Homology Associated Smooth Muscle Protein': Top Publications.
  • Loretan S et al: Unusual fatal petrositis presenting as myofascial pain and dysfunction of the temporal muscle.
  • Schraml C et al: Temporal course of perfusion in human masseter muscle during isometric contraction assessed by arterial spin labeling at 3T.
  • Eswaran H et al: Spatial-temporal analysis of uterine smooth muscle activity recorded during pregnancy.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705340225.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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