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1. Biomedical articles (top 50; 2010 to 2015)
1. Blyton F, Chuter V, Burns J: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness. J Foot Ankle Res; 2012;5:7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • BACKGROUND: Night-time calf cramping affects approximately 1 in 3 adults.
  • The aim of this study was to explore the experience of night-time calf cramp; if and where people seek treatment advice; and perceived treatment effectiveness.
  • METHODS: 80 adults who experienced night-time calf cramp at least once per week were recruited from the Hunter region, NSW, Australia through newspaper, radio and television advertisements.
  • All participants completed a pilot-tested survey about muscle cramp.
  • RESULTS: Median recalled age of first night-time calf cramp was 50 years.
  • Most participants recalled being awoken from sleep by cramping, and experiencing cramping of either calf muscle, calf-muscle soreness in the days following cramp and cramping during day-time.
  • Participants described their cramps as being 'unbearable', 'unmanageable' and 'cruel'.
  • One participant stated that 'sometimes I just wish I could cut my legs open' and another reported 'getting about 2 h sleep a night due to cramps'.
  • Most participants had sought advice about their night-time calf cramps from a health professional.
  • Participants identified 49 different interventions used to prevent night-time calf cramp.
  • Of all treatment ratings, 68% described the intervention used to prevent cramp as being 'useless' or of 'a little help'.
  • Of 14 participants who provided additional information regarding their use of quinine, eight had a current prescription of quinine for muscle cramp at the time of the survey.
  • CONCLUSION: Night time calf cramps typically woke sufferers from sleep, affected either leg and caused ongoing pain.
  • Most participants experienced little or no relief with current therapies used to prevent muscle cramp.
  • Most people who were taking quinine for muscle cramp were unaware that the Australian Therapeutic Goods Administration withdrew support of quinine for muscle cramp in 2004 due to the risk of thrombocytopaenia.
  • Case-control studies are required to identify therapeutic targets so that clinical trials can evaluate safe interventions to prevent recurrent cramp.

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  • (PMID = 22420923.001).
  • [ISSN] 1757-1146
  • [Journal-full-title] Journal of foot and ankle research
  • [ISO-abbreviation] J Foot Ankle Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3361473
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2. Blyton F, Ryan MM, Ouvrier RA, Burns J: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors. Neurology; 2011 Dec 13;77(24):2115-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • OBJECTIVES: To identify correlates of calf cramp in children with Charcot-Marie-Tooth disease type 1A (CMT1A).
  • Post hoc logistic regression analyses were performed to identify independent predictors of calf cramp.
  • RESULTS: Of the 81 children, 26 (32%) reported calf cramp, and 1 child each reported toe, quadriceps, or arm cramp.
  • Calf cramp was associated (p < 0.05) with older age; the presence of hand tremor; stronger foot inversion, eversion, dorsiflexion, and plantarflexion; and better performance in long-jump and 9-hole peg tests.
  • Logistic regression analysis revealed only increasing age (odds ratio [OR] 1.32, 95% confidence interval [CI] 1.11-1.58; p = 0.002) and the presence of hand tremor (OR 3.81, 95% CI 1.18-12.56; p = 0.028) as independent predictors of calf cramp.
  • CONCLUSION: Calf cramps are common in children with CMT1A and worsen with age.
  • This study revealed a previously unrecognized link between cramp and hand tremor in children with CMT1A.
  • Further investigation of proposed mechanisms and risk factors common to both cramp and tremor will contribute to our understanding of these common complications of CMT1A.
  • [MeSH-major] Charcot-Marie-Tooth Disease / complications. Muscle Cramp / complications


3. Senapin S, Phiwsaiya K, Gangnonngiw W, Flegel TW: False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia. J Negat Results Biomed; 2011;10:10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] False rumours of disease outbreaks caused by infectious myonecrosis virus (IMNV) in the whiteleg shrimp in Asia.
  • BACKGROUND: Infectious myonecrosis virus (IMNV) disease outbreaks in cultivated whiteleg shrimp Penaeus (Litopenaeus) vannamei are characterized by gross signs of whitened abdominal muscles and by slow mortality reaching up to 70%.
  • In 2006 the first disease outbreaks caused by IMNV in Asia occurred in Indonesia.
  • Since then rumours have periodically circulated about IMNV disease outbreaks in other Asian countries.
  • In most cases, our shrimp samples for which tissue sections were possible showed signs of muscle cramp syndrome that also commonly causes muscle whitening in stressed whiteleg shrimp.
  • Thus, we suspect that most of the false rumours in Asia about IMNV outside of Indonesia have resulted because of muscle cramp syndrome.
  • We suspect that confusion has arisen because muscle cramp syndrome causes similar signs of whitened tail muscles in whiteleg shrimp.

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  • [Cites] Dis Aquat Organ. 2005 Feb 28;63(2-3):261-5 [15819442.001]
  • [Cites] Dis Aquat Organ. 2007 May 9;75(3):183-90 [17629112.001]
  • [Cites] J Gen Virol. 2006 Apr;87(Pt 4):987-96 [16528049.001]
  • (PMID = 21813002.001).
  • [ISSN] 1477-5751
  • [Journal-full-title] Journal of negative results in biomedicine
  • [ISO-abbreviation] J Negat Results Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / RNA, Viral
  • [Other-IDs] NLM/ PMC3199911
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4. Zolfaghari M, Asgari P, Bahramnezhad F, AhmadiRad S, Haghani H: Comparison of two educational methods (family-centered and patient-centered) on hemodialysis: Related complications. Iran J Nurs Midwifery Res; 2015 Jan-Feb;20(1):87-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Hypotension and muscular cramp are the common complications of hemodialysis.
  • Blood pressure and muscle cramp were checked using researcher-made checklist in three stages (before and at the second and fourth week after intervention).
  • Hypotension (before the start of dialysis, at the first, second, and third hour, and at the end hours) and muscle cramp (in the middle of hemodialysis and the end half an hour) were also checked.
  • RESULTS: Before intervention, the two groups did not show significant difference in terms of hypotension [with P = 0.91 and variations mean of 1.60 (1.30)] and muscle cramp [with P = 0.50 and variations mean of 1.06 (1.01)].
  • In the second and fourth week after intervention, there was significant difference between the two groups in terms of hypotension [with P = 0.016 and variations mean of 0.70 (0.70) and P = 0.02 and variations mean of 0.86 (0.62)] and muscle cramp [with P = 0.01 and variations mean of 0.46 (0.86) and P = 0.02 and variations mean of 1 (1.05)].

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  • (PMID = 25709696.001).
  • [ISSN] 1735-9066
  • [Journal-full-title] Iranian journal of nursing and midwifery research
  • [ISO-abbreviation] Iran J Nurs Midwifery Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4325420
  • [Keywords] NOTNLM ; Family-centered nursing / Iran / hemodialysis / hypotension / muscular cramp / patient-centered care
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5. Najafi L, Khamseh ME, Malek M, Baradaran HR, Aghili SM, Kia M, Aghili R: Rapid screening of diabetic polyneuropathy: selection of accurate symptoms and signs in an outpatient clinical setting. Acta Med Iran; 2014;52(7):519-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In patients' history, the most sensitive (99.4%) and accurate (78%) symptoms were muscle cramp and weakness.
  • Findings show that symptoms such as a muscle cramp, weakness, numbness, and prickling, as well as signs such as ankle reflexes, appearance of feet, and vibration could be used as the most accurate tests for rapid diagnosis of DPN.

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  • (PMID = 25135261.001).
  • [ISSN] 1735-9694
  • [Journal-full-title] Acta medica Iranica
  • [ISO-abbreviation] Acta Med Iran
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
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6. Suganami A, Sakamoto K, Ono T, Watanabe H, Hijioka N, Murakawa M, Kimura J: The inhibitory effect of shakuyakukanzoto on K+ current in H9c2 cells. Fukushima J Med Sci; 2014;60(1):22-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Shakuyakukanzoto (shao-yao-gan-cao-tang) is a commonly used Chinese traditional herbal medicine for the treatment of acute pain with muscle cramp.
  • This may be a part of the Shakuyakukanzoto mechanism for improving muscle pain.
  • [MeSH-minor] Animals. Cell Line. Drug Combinations. Glycyrrhiza / chemistry. Glycyrrhizic Acid / pharmacology. Humans. Ion Transport / drug effects. Muscle Cramp / drug therapy. Muscle Cramp / metabolism. Muscle Fibers, Skeletal / drug effects. Muscle Fibers, Skeletal / metabolism. RNA, Small Interfering / genetics. Rats. Shab Potassium Channels / antagonists & inhibitors. Shab Potassium Channels / genetics. Shab Potassium Channels / metabolism

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  • (PMID = 24670676.001).
  • [ISSN] 2185-4610
  • [Journal-full-title] Fukushima journal of medical science
  • [ISO-abbreviation] Fukushima J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 0 / Drugs, Chinese Herbal; 0 / Kcnb1 protein, rat; 0 / RNA, Small Interfering; 0 / Shab Potassium Channels; 0 / shakuyaku-kanzoh-toh; 6FO62043WK / Glycyrrhizic Acid; RWP5GA015D / Potassium
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7. 'Muscle Cramp Chronic': Top Publications. BioMedLib Review OC; ;MuscleCrampChronic:710469169. ISSN: 2331-5717. 2015/2/21; updates online.
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  • [Title] 'Muscle Cramp Chronic': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'muscle cramp chronic'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 5 publications, and group two 177 publications.
  • Here are the top 3.
  • Porta M: A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.
  • HOWELL TH: Relaxation of muscle spasm in chronic arthritis by prostigmin.
  • PERNIKOFF M: TREATMENT OF ACUTE AND CHRONIC MUSCLE SPASM WITH DIAZEPAM.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710469169.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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8. 'Calf Muscle Cramp': Top Publications. BioMedLib Review OC; ;CalfMuscleCramp:709904985. ISSN: 2331-5717. 2015/11/10; updates online.
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  • [Title] 'Calf Muscle Cramp': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'calf muscle cramp'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 12 publications, and group two 75 publications.
  • Here are the top 7.
  • Coppin RJ et al: Managing nocturnal leg cramps--calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial.
  • Kim DH et al: The effects of myofascial trigger point injections on nocturnal calf cramps.
  • Cooper IF et al: 'Signs or Symptoms' associated with 'Calf Cramp Muscles': Top Publications.
  • Hawke F et al: Factors associated with night-time calf muscle cramps: a case-control study.
  • Abreu-Gerke L et al: [Acral necroses after therapy with quinine sulfate for calf cramps].
  • Hawke F et al: Impact of nocturnal calf cramping on quality of sleep and health-related quality of life.
  • Summers KM et al: Predictors of calf cramping in rugby league.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709904985.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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9. Drouet A: [Management of muscle cramp: what's to be done?]. Rev Prat; 2013 May;63(5):619-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of muscle cramp: what's to be done?].
  • [Transliterated title] Comment optimiser la prise en charge des crampes musculaires?
  • Muscle cramp is characterized by involuntary, painful, visible contraction of a muscle (or a part of muscle) and is always associated with irregular repetitive firing of motor unit action potentials (200 à 300 Hz) which is caused by hyperexcitability of intramuscular terminal motor axons.
  • A careful history and examination should allow the physician to determine the significance of cramp.
  • ENMG and biological tests are needed in cases of severe symptoms (severity and frequency of cramps) and/or abnormal examination.
  • Idiopathic and secondary (drug or metabolic disorders) cramps are the most common groups, but it's very important to search the motor unit diseases (neuropathy, radiculopathy, plexopathy, neuromyotonia, and a cramp fasciculation syndrome which can preceded ALS).
  • The first goal in management of cramp is to determine if there is an underlying cause and the second to use physical measures (stretching), because, pharmacologic treatments have a moderate interest because of the potential of toxicity (quinine sulfate) or a little effectiveness (vitamin B complex, naftidrofuryl, and calcium channel blockers such as diltiazem, gabapentin).
  • Isolated cramp doesn't need treatment.
  • [MeSH-major] Muscle Cramp / therapy

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  • (PMID = 23789484.001).
  • [ISSN] 0035-2640
  • [Journal-full-title] La Revue du praticien
  • [ISO-abbreviation] Rev Prat
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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10. Okada Y, Ayaki T, Matsumoto R, Ito H, Takahashi R, Nakano S: [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement]. Rinsho Shinkeigaku; 2012;52(10):774-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement].
  • A 53-year-old man presented mild, but gradually worsening, distal-dominant upper bilateral limbs weakness and muscle cramp in both legs from the age of 30.
  • He had no obvious muscle atrophy during the course of the disease.
  • Muscle biopsy of the right lateral vastus muscle showed myopathic changes with round or helical hyaline inclusions in eosinophilic on H&E staining and dark green on modified Gomori trichrome.
  • While MFM patients are sometimes reported to develop serious conditions such as severe weakness, cardiomyopathy or respiratory failure, which require a pacemaker or mechanical ventilator, our case only had mild distal dominant limb weakness and muscle cramps.
  • [MeSH-major] Arrhythmogenic Right Ventricular Dysplasia / complications. Arrhythmogenic Right Ventricular Dysplasia / diagnosis. Muscle Cramp / etiology. Muscle, Skeletal. Muscular Atrophy / etiology
  • [MeSH-minor] Connectin / metabolism. Desmin / metabolism. Diagnosis, Differential. Disease Progression. Extremities. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 23064629.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Connectin; 0 / Desmin; 0 / MYOT protein, human; Arrhythmogenic Right Ventricular Dysplasia, Familial, 7
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11. Miller KC, Knight KL, Wilding SR, Stone MB: Duration of electrically induced muscle cramp increased by increasing stimulation frequency. J Sport Rehabil; 2012 May;21(2):182-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • CONTEXT: Electrically induced muscle cramps (EIMC) do not last long enough to study many cramp treatments.
  • Increasing stimulation frequency lengthens cramp duration; it is unknown which frequency elicits the longest EIMC.
  • OBJECTIVE: To determine which stimulation frequency elicits the longest EIMC and whether cramp duration and stimulation frequency are correlated.
  • PARTICIPANTS: 20 participants (12 male, 8 female; age 20.7 ± 0.6 y; height 174.9 ± 1.9 cm; mass 76.6 ± 2.2 kg) with a self-reported history of muscle cramps in their lower extremities within the 6 mo before the study.
  • After 1 min of rest, stimulation frequency increased in 2-Hz increments until a cramp occurred in the flexor hallucis brevis.
  • The stimulation frequency at which a cramp occurred was termed cramp threshold frequency (TF).
  • Cramp duration was determined using strict clinical criteria (loss of hallux rigidity and return of hallux neutral).
  • On the next 4 consecutive days, participants were stimulated at 5, 10, 15, or 20 Hz above TF, and cramp duration was reassessed.
  • MAIN OUTCOME MEASURES: Cramp TF and duration.
  • RESULTS: Cramp TF was 16.9 ± 5.1 Hz.
  • Cramp duration was longer at 15 and 20 Hz above TF (77.9 ± 37.6 s and 69.5 ± 36.9 s, respectively) than at TF (40.8 ± 34.0 s; P < .05).
  • Cramp duration and TF were highly correlated (r = .90).
  • CONCLUSIONS: Stimulating at 15 and 20 Hz above cramp TF produces the longest-lasting EIMC.
  • [MeSH-major] Electric Stimulation / adverse effects. Muscle Cramp / etiology. Muscle, Skeletal / physiology
  • [MeSH-minor] Cross-Over Studies. Electromyography. Female. Foot. Humans. Male. Muscle Contraction / physiology. Tibial Nerve. Time Factors. Young Adult

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  • (PMID = 22104040.001).
  • [ISSN] 1543-3072
  • [Journal-full-title] Journal of sport rehabilitation
  • [ISO-abbreviation] J Sport Rehabil
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
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12. Braulick KW, Miller KC, Albrecht JM, Tucker JM, Deal JE: Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency. Br J Sports Med; 2013 Jul;47(11):710-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency.
  • OBJECTIVE: Many clinicians believe that exercise-associated muscle cramps (EAMC) occur because of dehydration.
  • Mild hypohydration (3% body mass loss) does not alter threshold frequency (TF), a measure of cramp susceptibility, when fatigue and exercise intensity are controlled.
  • Dominant limb flexor hallucis brevis cramp TF, cramp electromyography (EMG) amplitude and cramp intensity were measured in 10 euhydrated, unacclimated men (age=24±4 years, height=184.2±4.8 cm, mass=84.8±11.4 kg).
  • Cramp variables were reassessed posthypohydration.
  • They lost 4.7±0.5% of their body mass (3.9±0.5 litres of fluid), 4.0±1.5 g of Na(+) and 0.6±0.1 g K(+) via exercise-induced sweating.
  • Significant (n=5) or serious hypohydration (n=5) did not alter cramp TF (euhydrated=15±5 Hz, hypohydrated=13±6 Hz; F1,9=3.0, p=0.12), cramp intensity (euhydrated= 94.2±41%, hypohydrated=115.9±73%; F1,9=1.9, p=0.2) or cramp EMG amplitude (euhydrated=0.18±0.06 µV, hypohydrated= 0.18±0.09 µV; F1,9=0.1, p=0.79).
  • CONCLUSIONS: Significant and serious hypohydration with moderate electrolyte losses does not alter cramp susceptibility when fatigue and exercise intensity are controlled.
  • Neuromuscular control may be more important in the onset of muscle cramps than dehydration or electrolyte losses.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology
  • [MeSH-minor] Adolescent. Adult. Analysis of Variance. Biological Markers / blood. Electromyography. Exercise / physiology. Humans. Male. Muscle Fatigue / physiology. Muscle, Skeletal / physiology. Sweat / chemistry. Young Adult

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  • (PMID = 23222192.001).
  • [ISSN] 1473-0480
  • [Journal-full-title] British journal of sports medicine
  • [ISO-abbreviation] Br J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biological Markers
  • [Keywords] NOTNLM ; Dehydration / Muscle cramping
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13. Bischoff M: [From muscle cramp to rhabdomyolysis: what is causing muscle pain?]. MMW Fortschr Med; 2012 Oct 4;154(17):26-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [From muscle cramp to rhabdomyolysis: what is causing muscle pain?].
  • [MeSH-major] Muscle Cramp / etiology. Pain / etiology. Rhabdomyolysis / etiology
  • [MeSH-minor] Diagnosis, Differential. Humans. Medical History Taking. Muscle Weakness / etiology. Physical Examination

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  • (PMID = 23088029.001).
  • [ISSN] 1438-3276
  • [Journal-full-title] MMW Fortschritte der Medizin
  • [ISO-abbreviation] MMW Fortschr Med
  • [Language] ger
  • [Publication-type] News
  • [Publication-country] Germany
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14. 'Leg Muscle Cramp': Top Publications. BioMedLib Review OC; ;LegMuscleCramp:710549787. ISSN: 2331-5717. 2015/12/22; updates online.
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  • [Title] 'Leg Muscle Cramp': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'leg muscle cramp'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 18 publications, and group two 213 publications.
  • Here are the top 10.
  • Orlin JR et al: Leg cramps in pregnancy caused by chronic compartment syndrome and relieved by fasciotomy after childbirth.
  • Ohtori S et al: Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.
  • Sebo P et al: Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations.
  • Garrison SR et al: Seasonal effects on the occurrence of nocturnal leg cramps: a prospective cohort study.
  • Cooper IF et al: 'Pharmacologic Substances' associated with 'Cramps Of Lower Extremities': Top Publications.
  • Rana AQ et al: Differentiating nocturnal leg cramps and restless legs syndrome.
  • Hallegraeff JM et al: A clear definition of nocturnal leg cramps is essential for comparability of research.
  • Supakatisant C et al: Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial.
  • Garrison SR: Prophylactic stretching is unlikely to prevent nocturnal leg cramps.
  • Hogan DB: Quinine: not a safe drug for treating nocturnal leg cramps.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710549787.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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15. 'Thigh Muscle Cramp': Top Publications. BioMedLib Review CN; ;ThighMuscleCramp:710269587. ISSN: 2331-5717. 2015/5/17; updates online.
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  • [Title] 'Thigh Muscle Cramp': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'thigh muscle cramp'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 12 publications.
  • Here are the top 7.
  • Demircan MN et al: Cramp finding: can it be used as a new diagnostic and prognostic factor in lumbar disc surgery?.
  • Ogwumike OO et al: The SPLASH/ICPC integrity marathon in Ibadan, Nigeria: incidence and management of injuries and marathon-related health problems.
  • Hem E: [The charley horse that was cleaned up].
  • Wagner T et al: Strengthening and neuromuscular reeducation of the gluteus maximus in a triathlete with exercise-associated cramping of the hamstrings.
  • Mellin G et al: Referred limb symptoms in chronic low back pain.
  • Nakao K et al: [Late-onset sarcoglycanopathy: a cause of repeated muscle cramps after exertion].
  • Blyton F et al: Non-drug therapies for lower limb muscle cramps.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710269587.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. 'Foot Muscle Cramp': Top Publications. BioMedLib Review OC; ;FootMuscleCramp:709905211. ISSN: 2331-5717. 2015/4/10; updates online.
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  • [Title] 'Foot Muscle Cramp': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'foot muscle cramp'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 2 publications, and group two 58 publications.
  • Here is the first one.
  • Fredericson M et al: Disabling foot cramping in a runner secondary to paramyotonia congenita: a case report.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709905211.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. 'Trunk Muscle Cramp': Top Publications. BioMedLib Review CN; ;TrunkMuscleCramp:708561003. ISSN: 2331-5717. 2015/1/11; updates online.
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  • [Title] 'Trunk Muscle Cramp': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'trunk muscle cramp'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 16 publications.
  • Here are the top 9.
  • Kanai K et al: Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment.
  • FIELDS A: Leg cramps.
  • Abdeldaoui A et al: First Bite Syndrome: a little known complication of upper cervical surgery.
  • : Investigation of intermittent claudication.
  • Ochsner F: [The mucisian's cramp. About the illness of Robert Schumann].
  • Cooper IF et al: 'Steroids' associated with 'Muscles Of Upper Limb': Top Publications.
  • Alberca R et al: [The state of muscle cramp disease].
  • Cooper IF et al: 'Hormones' associated with 'Muscles Of Upper Limb': Top Publications.
  • Merletti R et al: Spinal involvement and muscle cramps in electrically elicited muscle contractions.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708561003.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. 'Muscle Cramp Disease Finding': Top Publications. BioMedLib Review OC; ;MuscleCrampDisease:710603799. ISSN: 2331-5717. 2015/5/24; updates online.
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  • [Title] 'Muscle Cramp Disease Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'muscle cramp disease finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 68 publications, and group two 1523 publications.
  • Here are the top 10.
  • Westwood AJ et al: CPAP treats muscle cramps in patients with obstructive sleep apnea.
  • Whittaker RG et al: Teaching video neuroimages: muscle cramps and a raised creatine kinase.
  • de Entrambasaguas M et al: [Fasciculations, cramps, and statins].
  • Cooper IF et al: 'Diseases or Syndromes' associated with 'Cramp S Writer Organic': Top Publications.
  • El-Tawil S et al: Quinine for muscle cramps.
  • Nishant et al: Nocturnal cramps in patients with lumbar spinal canal stenosis treated conservatively: a prospective study.
  • Orlin JR et al: Leg cramps in pregnancy caused by chronic compartment syndrome and relieved by fasciotomy after childbirth.
  • Ohtori S et al: Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Vidot H et al: Systematic review: the treatment of muscle cramps in patients with cirrhosis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710603799.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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19. Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans. Med Sci Sports Exerc; 2010 May;42(5):953-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • INTRODUCTION: Anecdotal evidence suggests that ingesting small volumes of pickle juice relieves muscle cramps within 35 s of ingestion.
  • No experimental evidence exists supporting the ingestion of pickle juice as a treatment for skeletal muscle cramps.
  • METHODS: On two different days (1 wk apart), muscle cramps were induced in the flexor hallucis brevis (FHB) of hypohydrated male subjects (approximately 3% body weight loss and plasma osmolality approximately 295 mOsm x kg(-1) H2O) via percutaneous tibial nerve stimulation.
  • Thirty minutes later, a second FHB muscle cramp was induced and was followed immediately by the ingestion of 1 mL x kg(-1) body weight of deionized water or pickle juice (73.9 +/- 2.8 mL).
  • RESULTS: Cramp duration and FHB EMG activity during the cramp were quantified, as well as the change in plasma constituents.
  • Cramp duration (water = 151.9 +/- 12.9 s and pickle juice = 153.2 +/- 23.7 s) and FHB EMG activity (water = 60% +/- 6% and pickle juice = 68% +/- 9% of maximum voluntary isometric contraction EMG activity) were similar during the initial cramp induction without fluid ingestion (P > 0.05).
  • During FHB muscle cramp induction combined with fluid ingestion, FHB EMG activity was again similar (water = 55% +/- 9% and pickle juice = 66% +/- 9% of maximum voluntary isometric contraction EMG activity, P > 0.05).
  • However, cramp duration was 49.1 +/- 14.6 s shorter after pickle juice ingestion than water (84.6 +/- 18.5 vs 133.7 +/- 15.9 s, respectively, P < 0.05).
  • CONCLUSIONS: Pickle juice, and not deionized water, inhibits electrically induced muscle cramps in hypohydrated humans.
  • We suspect that the rapid inhibition of the electrically induced cramps reflects a neurally mediated reflex that originates in the oropharyngeal region and acts to inhibit the firing of alpha motor neurons of the cramping muscle.
  • [MeSH-major] Acetic Acid / therapeutic use. Dehydration / complications. Electric Stimulation / adverse effects. Muscle Cramp / etiology. Muscle Cramp / therapy

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  • (PMID = 19997012.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Electrolytes; Q40Q9N063P / Acetic Acid
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20. Hawke F, Chuter V, Burns J: Impact of nocturnal calf cramping on quality of sleep and health-related quality of life. Qual Life Res; 2013 Aug;22(6):1281-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Impact of nocturnal calf cramping on quality of sleep and health-related quality of life.
  • PURPOSE: To evaluate the impact of nocturnal calf cramping (a condition that affects one in two people over 60 years of age) on quality of sleep and health-related quality of life.
  • METHODS: Eighty adults who experienced nocturnal calf cramp at least once per week and eighty age- and sex-matched controls who never experienced nocturnal cramp were recruited from the Greater Newcastle and Central Coast regions of New South Wales, Australia.
  • RESULTS: People who experienced nocturnal muscle cramps reported more sleep disturbance (p < 0.001), less adequate sleep (p = 0.001), less quantity of sleep (p = 0.02) and more snoring (p = 0.03).
  • Both sleep problem summary indices for the MOS-SS identified people who experienced nocturnal muscle cramp as having more sleep problems than the controls.
  • People who experienced nocturnal muscle cramps had lower health-related quality of life for the SF-36 domains role physical (p = 0.007), bodily pain (p = 0.003) and general health (p = 0.02).
  • The impact of nocturnal calf cramps on health-related quality of life was largely explained by their negative impact on quality of sleep.
  • CONCLUSIONS: Nocturnal calf muscle cramps are associated with substantially reduced quality of sleep and reduced physical aspects of health-related quality of life.
  • [MeSH-major] Circadian Rhythm. Health Status. Muscle Cramp / psychology. Quality of Life. Sleep

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  • (PMID = 23011494.001).
  • [ISSN] 1573-2649
  • [Journal-full-title] Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
  • [ISO-abbreviation] Qual Life Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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21. 'Type 2 Muscle Fiber Predominance': Top Publications. BioMedLib Review OC; ;Type2Muscle:708217430. ISSN: 2331-5717. 2015/7/12; updates online.
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  • [Title] 'Type 2 Muscle Fiber Predominance': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'type 2 muscle fiber predominance'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 1 publications, and group two 161 publications.
  • Here is the first one.
  • Telerman-Toppet N et al: Type 2 fiber predominance in muscle cramp and exertional myalgia.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708217430.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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22. Stone MB, Edwards JE, Huxel KC, Cordova ML, Ingersoll CD, Babington JP: Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise. J Sports Sci; 2010 Feb;28(4):399-405
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise.
  • Though clinical observations and laboratory data provide some support for the neuromuscular imbalance theory of the genesis of exercise-associated muscle cramps, no direct evidence has been published.
  • The purpose of this study was to determine the effect of local muscle fatigue on the threshold frequency of an electrically induced muscle cramp.
  • To determine baseline threshold frequency, a cramp was electrically induced in the flexor hallucis brevis of 16 apparently healthy participants (7 males, 9 females; age 25.1 +/- 4.8 years).
  • In the control condition, participants rested in a supine position for 30 min followed by another cramp induction to determine post-threshold frequency.
  • An increase in threshold frequency seems to demonstrate a decrease in one's propensity to cramp following the fatigue exercise regimen used.
  • These results contradict the proposed theory that suggests cramp propensity should increase following fatigue.
  • However, differences in laboratory versus clinical fatiguing exercise and contributions from other sources, as well as the notion of a graded response to fatiguing exercise, on exercise-associated muscle cramp and electrically induced muscle cramp should be considered.
  • [MeSH-major] Exercise / physiology. Muscle Contraction / physiology. Muscle Fatigue / physiology. Muscle, Skeletal / physiology

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  • (PMID = 20131142.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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23. Takenouchi T, Ohyagi M, Torii C, Kosaki R, Takahashi T, Kosaki K: Porencephaly in a fetus and HANAC in her father: Variable expression of COL4A1 mutation. Am J Med Genet A; 2015 Jan;167(1):156-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • COL4A1-associated disorders encompass a wide range of hereditary vasculopathy, including porencephaly and HANAC (adult-onset hemorrhagic stroke with cerebral aneurysm and retinal arterial tortuosity, renal cysts, and thenar muscle cramp).

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  • [Copyright] © 2014 Wiley Periodicals, Inc.
  • (PMID = 25425218.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; COL4A1 / HANAC / Porencephaly
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24. Miller KC, Burne JA: Golgi tendon organ reflex inhibition following manually applied acute static stretching. J Sports Sci; 2014;32(15):1491-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Golgi tendon organ disinhibition may contribute to exercise-associated muscle cramp (henceforth referred to as "cramps") genesis.
  • Static stretching pre-exercise is prescribed to prevent cramps based on the assumption golgi tendon organ inhibition remains elevated post-stretching.
  • If pre-stretching does prevent fatigue-induced cramping, the mechanism is unlikely to involve the autoinhibition produced by the golgi tendon organ reflex.
  • Further empirical research is needed to validate the proposed link between static stretching and cramping and then to investigate alternative mechanisms.
  • [MeSH-major] Mechanoreceptors / physiology. Motor Neurons / physiology. Muscle Contraction / physiology. Muscle Cramp / prevention & control. Muscle Stretching Exercises. Muscle, Skeletal / physiology. Reflex

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  • (PMID = 24716521.001).
  • [ISSN] 1466-447X
  • [Journal-full-title] Journal of sports sciences
  • [ISO-abbreviation] J Sports Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; alpha motor neuron / electrical stimulation / muscle cramp / tendon afferents
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25. Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I: Three percent hypohydration does not affect threshold frequency of electrically induced cramps. Med Sci Sports Exerc; 2010 Nov;42(11):2056-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • PURPOSE: Dehydration is hypothesized to cause exercise-associated muscle cramps.
  • The theory states that dehydration contracts the interstitial space, thereby increasing the pressure on nerve terminals and cramps ensue.
  • Inducing cramps with electrical stimulation minimizes many of the confounding factors associated with exercise-induced cramps (e.g., fatigue, metabolites).
  • Thus, our goal was to minimize fatigue and determine whether hypohydration decreases the electrical stimuli required to elicit cramping (termed "threshold frequency").
  • Dominant leg flexor hallucis brevis muscle cramps were induced before and after hypohydration, and threshold frequency was recorded.
  • CONCLUSIONS: Mild hypohydration with minimal neuromuscular fatigue does not seem to predispose individuals to cramping.
  • Thus, cramps may be more associated with neuromuscular fatigue than dehydration/electrolyte losses.
  • Health care professionals may have more success preventing exercise-associated muscle cramp by focusing on strategies that minimize neuromuscular fatigue rather than dehydration.
  • However, the effect of greater fluid losses on cramp threshold frequency is unknown and merits further research.
  • [MeSH-major] Dehydration / complications. Muscle Cramp / etiology. Muscle Fatigue

  • MedlinePlus Health Information. consumer health - Dehydration.
  • MedlinePlus Health Information. consumer health - Muscle Cramps.
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  • (PMID = 20351595.001).
  • [ISSN] 1530-0315
  • [Journal-full-title] Medicine and science in sports and exercise
  • [ISO-abbreviation] Med Sci Sports Exerc
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Ge HY, Arendt-Nielsen L: Latent myofascial trigger points. Curr Pain Headache Rep; 2011 Oct;15(5):386-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A latent myofascial trigger point (MTP) is defined as a focus of hyperirritability in a muscle taut band that is clinically associated with local twitch response and tenderness and/or referred pain upon manual examination.
  • Current evidence suggests that the temporal profile of the spontaneous electrical activity at an MTP is similar to focal muscle fiber contraction and/or muscle cramp potentials, which contribute significantly to the induction of local tenderness and pain and motor dysfunctions.

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  • (PMID = 21559783.001).
  • [ISSN] 1534-3081
  • [Journal-full-title] Current pain and headache reports
  • [ISO-abbreviation] Curr Pain Headache Rep
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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27. Blyton F, Chuter V, Walter KE, Burns J: Non-drug therapies for lower limb muscle cramps. Cochrane Database Syst Rev; 2012;1:CD008496
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-drug therapies for lower limb muscle cramps.
  • BACKGROUND: About one in every three adults are affected by lower limb muscle cramps.
  • For some people, these cramps reduce quality of life, quality of sleep and participation in activities of daily living.
  • Many interventions are available for lower limb cramps, but some are controversial, no treatment guidelines exist, and often people experience no benefit from the interventions prescribed.
  • OBJECTIVES: To assess the effects of non-drug, non-invasive treatments for lower limb cramp.
  • SEARCH METHODS: We searched the Cochrane Neuromuscular Disease Group Specialized Register (13 September 2011) using the terms: cramp, spasm, contracture, charley horse and lower limb, lower extremity, foot, calf, leg, thigh, gastrocnemius, hamstring, quadriceps.
  • SELECTION CRITERIA: All randomised controlled trials of non-drug, non-invasive interventions trialled over at least four weeks for the prevention of lower limb muscle cramps in any group of people.
  • We selected only trials that included at least one of the following outcomes: cramp frequency, cramp severity, health-related quality of life, quality of sleep, participation in activities of daily living and adverse outcomes.
  •  All participants were age 60 years or over and had received a repeat prescription from their general practitioner of quinine for nighttime cramps in the preceding three months.
  • Forty-nine participants were advised to complete lean-to-wall calf muscle stretching held for 10 s three times per day.
  • After 12 weeks, there was no statistically significant difference in recalled cramp frequency between groups.
  • AUTHORS' CONCLUSIONS: There is limited evidence on which to base clinical decisions regarding the use of non-drug therapies for the treatment of lower limb muscle cramp.
  • [MeSH-major] Lower Extremity. Muscle Cramp / therapy. Muscle Stretching Exercises / methods
  • [MeSH-minor] Aged. Humans. Middle Aged. Muscle Relaxants, Central / therapeutic use. Quinine / therapeutic use. Randomized Controlled Trials as Topic

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  • (PMID = 22258986.001).
  • [ISSN] 1469-493X
  • [Journal-full-title] The Cochrane database of systematic reviews
  • [ISO-abbreviation] Cochrane Database Syst Rev
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Muscle Relaxants, Central; A7V27PHC7A / Quinine
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28. Hokari S, Koya T, Shimaoka Y, Nakayama H, Terada M, Suzuki E: [Interstitial pneumonia associated with stiff-person syndrome]. Nihon Kokyuki Gakkai Zasshi; 2010 Feb;48(2):162-5
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  • Three months after the diagnosis of interstitial pneumonia, he noticed neurological symptoms, such as facial spasms, dysphagia, muscle rigidity and muscle cramp, and repeatedly received clonazepam.

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  • (PMID = 20184250.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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29. Cooper IF, Siadaty MS: 'Intellectual Products' associated with 'Cramp Finding': Top Publications. BioMedLib Review; IntellectualProduct;CrampFinding:706134989. ISSN: 2331-5717. 2014/1/23
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  • [Title] 'Intellectual Products' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Intellectual Product' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Intellectual Product'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 6157 publications.
  • Here are the top 10.
  • Bilbey DL et al: Muscle cramps and magnesium deficiency: case reports.
  • Chiba S et al: Autosomal dominant muscle cramp syndrome in a Japanese family.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • Demircan MN et al: Cramp finding: can it be used as a new diagnostic and prognostic factor in lumbar disc surgery?.
  • Cooper IF et al: 'Steroids' associated with 'Cramps Of Lower Extremities': Top Publications.
  • Van den Bergh P et al: Familial muscle cramps with autosomal dominant transmission.
  • Sebo P et al: Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Mohan P et al: Medical image. Recurrent muscle cramps in chronic diarrhoea. Primary intestinal lymphangiectasia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706134989.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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30. 'Continuous Discharges Emg Motor Polyphasic Unit': Top Publications. BioMedLib Review CN; ;ContinuousDischargesEmg:709150738. ISSN: 2331-5717. 2015/1/8; updates online.
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  • [Title] 'Continuous Discharges Emg Motor Polyphasic Unit': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'continuous discharges emg motor polyphasic unit'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 2 publications.
  • Here is the first one.
  • Grisold W et al: The syndrome of continuous muscle fibre activity following gold therapy.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709150738.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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31. Arimura K, Watanabe O: [Immune-mediated neuromyotonia (Isaacs' syndrome)--clinical aspects and pathomechanism]. Brain Nerve; 2010 Apr;62(4):401-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Isaacs' syndrome (immune-mediated neuromyotonia) is an antibody-mediated potassium channel disorder (channelopathy).
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction (pseudomyotonia), and hyperhidrosis; these symptoms are due to hyperexcitability of the peripheral nerve, including autonomic nerve.
  • Recent studies show that this disease is not infrequently associated with neoplasm, especially thymoma.

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  • (PMID = 20420181.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Potassium Channels; 0 / Potassium Channels, Voltage-Gated
  • [Number-of-references] 32
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32. Liu SL, Chen G, Zhao YP, Wu WM, Zhang TP: Optimized dose of imatinib for treatment of gastrointestinal stromal tumors: a meta-analysis. J Dig Dis; 2013 Jan;14(1):16-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The rates of rash, hemorrhage, nausea, vomiting and taste disturbance increased as dose increased (P < 0.05), whereas the incidence of headache, abdominal pain, edema, fatigue, anemia, infection, muscle cramp and constipation was nearly identical and showed no significant difference.

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  • [Copyright] © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
  • (PMID = 23121684.001).
  • [ISSN] 1751-2980
  • [Journal-full-title] Journal of digestive diseases
  • [ISO-abbreviation] J Dig Dis
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; BKJ8M8G5HI / imatinib
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33. Watanabe O: [Isaacs's syndrome and associated diseases]. Rinsho Shinkeigaku; 2013;53(11):1067-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Isaacs' syndrome is an antibody-mediated potassium channel disorder.
  • Clinical symptoms of Isaacs' syndrome are characterized by muscle cramp, slow relaxation following muscle contraction, and hyperhidrosis.

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  • (PMID = 24291881.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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34. Ge HY, Fernández-de-Las-Peñas C, Yue SW: Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation. Chin Med; 2011;6:13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The spontaneous electrical activity represents focal muscle fiber contraction and/or muscle cramp potentials depending on trigger point sensitivity.
  • Nociceptor and non-nociceptor sensitization at myofascial trigger points may be part of the process of muscle ischemia associated with sustained focal muscle contraction and/or muscle cramps.

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  • (PMID = 21439050.001).
  • [ISSN] 1749-8546
  • [Journal-full-title] Chinese medicine
  • [ISO-abbreviation] Chin Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3070691
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35. Takashima H: [History of hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P)]. Rinsho Shinkeigaku; 2013;23(11):1196-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We established a new disease autosomal dominant hereditary motor and sensory neuropathy with proximal dominant involvement (HMSNP) in 1997, in Okinawa, Japan.
  • This disease is characterized by proximal dominant neurogenic atrophy with fasciculations, painful muscle cramp, obvious sensory nerve involvement, areflexia, high incidence of elevated creatine kinase levels, hyperlipidemia and hyperglycemia. (MIM %604484).
  • Most HMSNP patients have severe muscle atrophy and finally the tracheostomy and artificial ventilation are required.
  • Therefore, we initially thought to classify HMSNP into a subtype of motor neuron disease (MND) like familial amyotrophic lateral sclerosis (FALS) or spinal muscular atrophy (SMA).
  • Therefore, as the disease showed severe sensory involvement, we categorized HMSNP in subtype of HMSN at that time.

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  • (PMID = 24291927.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Japan
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36. Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Cramp Finding': Top Publications. BioMedLib Review; DiseaseOrSyndrome;CrampFinding:705073935. ISSN: 2331-5717. 2014/7/5
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  • [Title] 'Diseases or Syndromes' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 27 publications, and group two 1397 publications.
  • Here are the top 10.
  • Allen RE et al: Nocturnal leg cramps.
  • Ohtori S et al: Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.
  • Blyton F et al: Muscle cramp in pediatric Charcot-Marie-Tooth disease type 1A: prevalence and predictors.
  • : Information from your family doctor. Nocturnal leg cramps.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Westwood AJ et al: CPAP treats muscle cramps in patients with obstructive sleep apnea.
  • Rana AQ et al: Differentiating nocturnal leg cramps and restless legs syndrome.
  • Atluri DK et al: An alternative treatment for muscle cramps in patients with liver cirrhosis.
  • Ditch SM et al: A college student with muscle cramps and weakness. Diagnosis: Bulimia nervosa, purging subtype, complicated by rhabdomyolysis and acute renal failure.
  • Okada Y et al: [Patient of myofibrillar myopathy associated with muscle cramp and distal muscle involvement].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705073935.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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37. Hara K, Watanabe O, Shibano K, Ishiguro H: [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity]. Rinsho Shinkeigaku; 2012;52(9):677-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity].
  • A 21-year-old man complained of severe pain and muscle twitching localized in his right arm.
  • Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia.
  • Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges.
  • This case with neither muscle cramp nor myokymia expands the phenotype of anti VGKC-complex antibody associated disorder.

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  • (PMID = 22989904.001).
  • [ISSN] 1882-0654
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Biological Markers; 0 / Immunoglobulins, Intravenous; 0 / Potassium Channels, Voltage-Gated; X4W7ZR7023 / Methylprednisolone
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38. 'Foot Cramping At Night': Top Publications. BioMedLib Review CN; ;FootCrampingAt:708461429. ISSN: 2331-5717. 2015/1/12; updates online.
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  • [Title] 'Foot Cramping At Night': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'foot cramping at night'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 3 publications.
  • Here is the first one.
  • Blyton F et al: Unknotting night-time muscle cramp: a survey of patient experience, help-seeking behaviour and perceived treatment effectiveness.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708461429.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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39. Xu C, Qi J, Shi Y, Feng Y, Zang W, Zhang J: Phenotypic variation of Val1589Met mutation in a four-generation Chinese pedigree with mild paramyotonia congenitia: case report. Int J Clin Exp Pathol; 2015;8(1):1050-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All members shared the characteristics of mild muscle cramp and stiffness induced by exercise or exposed to cold.

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  • (PMID = 25755818.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4348932
  • [Keywords] NOTNLM ; Paramyotonia congenita / SCN4A / Val1589Met / myotonia / phenotype
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40. Cooper IF, Siadaty MS: 'Qualitative Concepts' associated with 'Cramp Finding': Top Publications. BioMedLib Review; QualitativeConcept;CrampFinding:706475404. ISSN: 2331-5717. 2014/1/27
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  • [Title] 'Qualitative Concepts' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Qualitative Concept' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Qualitative Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 12 publications, and group two 691 publications.
  • Here are the top 7.
  • Cooper IF et al: 'Steroids' associated with 'Cramp Finding': Top Publications.
  • Maxwell SK et al: Characteristics of muscle cramps in patients with polyneuropathy.
  • Braulick KW et al: Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency.
  • Hawke F et al: Factors associated with night-time calf muscle cramps: a case-control study.
  • Lee KK et al: Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
  • Sato A et al: [An autopsy case of amyotrophic lateral sclerosis with prominent muscle cramps, fasciculation, and high titer of anti-voltage gated potassium channel (VGKC) complex antibody].
  • Rana AQ et al: Differentiating nocturnal leg cramps and restless legs syndrome.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706475404.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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41. Kaifuchi N, Omiya Y, Kushida H, Fukutake M, Nishimura H, Kase Y: Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca(2+) release in rat skeletal muscle. J Nat Med; 2015 Jul;69(3):287-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca(2+) release in rat skeletal muscle.
  • A double-blind study reported that SKT significantly ameliorated painful muscle cramp in cirrhosis patients without the typical severe side effects of muscle weakness and central nervous system (CNS) depression.
  • Previous basic studies reported that SKT and its active components induced relaxation by a direct action on skeletal muscle and that SKT did not depress CNS functions; however, why SKT has a lower incidence of muscle weakness remains unknown.
  • Our study demonstrated that SKT and five G. radix isolates, which are responsible for the antispasmodic effect of SKT, did not inhibit the twitch contraction in contrast to dantrolene sodium, a direct-acting peripheral muscle relaxant, indicating that the mechanisms of muscle contraction of SKT and dantrolene in skeletal muscle differ.
  • These findings suggest that SKT does not reduce the contractile force in skeletal muscle under physiological conditions, i.e., SKT may have a low risk of causing muscle weakness in clinical use.
  • Considering that most muscle relaxants and anticonvulsants cause various harmful side effects such as weakness and CNS depression, SKT appears to have a benign safety profile.

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  • (PMID = 25783410.001).
  • [ISSN] 1861-0293
  • [Journal-full-title] Journal of natural medicines
  • [ISO-abbreviation] J Nat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Other-IDs] NLM/ PMC4460294
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42. Tayebi Khosroshahi H, Habibi Asl B, Habibzadeh A, Chaichi P, Ghanbarpour A, Hossein Badie A: Comparison of vitamin e and L-carnitine, separately or in combination in patients with intradialytic complications. Nephrourol Mon; 2013 Sep;5(4):862-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The most common complications during dialysis are hypotension and muscle cramps.
  • PATIENTS AND METHODS: In a prospective study, 20 patients with end stage renal disease on chronic hemodialysis that had intradialytic complications such as hypotension, muscle cramp, nausea, vomiting and headache were studied.
  • RESULTS: All three treatments significantly reduced frequency of muscle cramps in comparison to baseline values.
  • Vitamin E alone and in combination with L-carnitine reduced the frequency of muscle cramps more effectively.

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  • (PMID = 24350082.001).
  • [ISSN] 2251-7006
  • [Journal-full-title] Nephro-urology monthly
  • [ISO-abbreviation] Nephrourol Mon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3842554
  • [Keywords] NOTNLM ; Carnitine / Kidney Failure, Chronic / Renal Dialysis / Vitamin E
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43. Kim HJ, Kim CK, Carpentier A, Poortmans JR: Studies on the safety of creatine supplementation. Amino Acids; 2011 May;40(5):1409-18
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Anecdotal reports from athletes have appeared on muscle cramp and gastrointestinal complaints during creatine supplementation, but the incidence of these is limited and not necessarily linked to creatine itself.
  • We advise that high-dose (>3-5 g/day) creatine supplementation should not be used by individuals with pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate).

  • MedlinePlus Health Information. consumer health - Kidney Diseases.
  • HSDB. structure - CREATINE.
  • ResearchGate. author profiles.
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  • (PMID = 21399917.001).
  • [ISSN] 1438-2199
  • [Journal-full-title] Amino acids
  • [ISO-abbreviation] Amino Acids
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] MU72812GK0 / Creatine
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44. 'Cramp Night': Top Publications. BioMedLib Review OC; ;CrampNight:709553889. ISSN: 2331-5717. 2015/4/6; updates online.
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  • [Title] 'Cramp Night': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'cramp night'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 103 publications.
  • Here are the top 10.
  • : Night cramp.
  • Craddock D: Quinine for night cramps.
  • : Quinine for night cramps.
  • Cooper IF et al: 'Signs or Symptoms' associated with 'Cramp In Lower Leg Associated With Rest': Top Publications.
  • Henry J: Quinine for night cramps.
  • Dunn NR: Effectiveness of quinine for night cramps.
  • Brooks MH: Quinine for night cramps.
  • Cooper IF et al: 'Temporal Concepts' associated with 'Cramp In Lower Leg Associated With Rest': Top Publications.
  • Sugar O: Causes of night cramps.
  • EXTON-SMITH AN: Night cramps in the elderly.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709553889.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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45. Cooper IF, Siadaty MS: 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications. BioMedLib Review; NaturalPhenomenonOr;CrampFinding:706151289. ISSN: 2331-5717. 2014/11/23
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  • [Title] 'Natural Phenomena or Processes' associated with 'Cramp Finding': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Natural Phenomenon or Process' for 'cramp finding'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Natural Phenomenon or Process'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 15 publications, and group two 2827 publications.
  • Here are the top 9.
  • Miller KC et al: Reflex inhibition of electrically induced muscle cramps in hypohydrated humans.
  • Serrao M et al: Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps.
  • Merletti R et al: Spinal involvement and muscle cramps in electrically elicited muscle contractions.
  • Miller KC et al: Duration of electrically induced muscle cramp increased by increasing stimulation frequency.
  • Molema MM et al: Caffeine and muscle cramps: a stimulating connection.
  • Nilsson SE: [Electromagnetic therapy in restless legs syndrome and nocturnal leg muscle cramps. Same effect of pulsating electromagnetic fields and placebo].
  • Miller KC et al: Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
  • TILLE D: [Initial fever cramps and the weather].
  • Minetto MA et al: Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706151289.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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46. Giorgio E, Vaula G, Bosco G, Giacone S, Mancini C, Calcia A, Cavalieri S, Di Gregorio E, Rigault De Longrais R, Leombruni S, Pinessi L, Cerrato P, Brusco A, Brussino A: Two families with novel missense mutations in COL4A1: When diagnosis can be missed. J Neurol Sci; 2015 May 15;352(1-2):99-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mutations in COL4A1, encoding one of the six collagen type IV proteins, cover a wide spectrum of autosomal dominant overlapping phenotypes including porencephaly, small-vessel disease and hemorrhagic stroke, leukoencephalopathy, hereditary angiopathy with nephropathy, aneurysms and muscle cramp (HANAC) syndrome, and Walker-Warburg syndrome.
  • We studied two Italian families in which the proband had a clinical diagnosis of COL4A1-related disorder.
  • The c.1249G>C (p.Gly417Arg) segregated in four subjects with variable neurological phenotypes, namely leukoencephalopathy with muscle symptoms, brain small-vessel disease, and mild infantile encephalopathy.

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  • [Copyright] Copyright © 2015 Elsevier B.V. All rights reserved.
  • (PMID = 25873210.001).
  • [ISSN] 1878-5883
  • [Journal-full-title] Journal of the neurological sciences
  • [ISO-abbreviation] J. Neurol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; COL4A1 / COL4A2 / Fetal porencephaly / Hereditary angiopathy with nephropathy, aneurysms and muscle cramp (HANAC) syndrome / Porencephaly / Variable expressivity
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47. Ichikawa T, Naota T, Miyaaki H, Miuma S, Isomoto H, Takeshima F, Nakao K: Effect of an oral branched chain amino acid-enriched snack in cirrhotic patients with sleep disturbance. Hepatol Res; 2010 Oct;40(10):971-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The items, as major symptoms of cirrhotic patients, were as follows: hand tremor, appetite loss, muscle cramp of foot, fatigue, decreased strength, anxiety, abdominal fullness, abdominal pain and a feeling of low energy.
  • However, the cirrhotic symptom-related score was positively relation with the Child-Pugh score at the time of patient entry, and we were unable to identify the item that related to ESS.

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  • [Copyright] © 2010 The Japan Society of Hepatology.
  • (PMID = 20887332.001).
  • [ISSN] 1872-034X
  • [Journal-full-title] Hepatology research : the official journal of the Japan Society of Hepatology
  • [ISO-abbreviation] Hepatol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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48. 'Cramp Fasciculation Syndromes': Top Publications. BioMedLib Review OC; ;CrampFasciculationSyndromes:710496107. ISSN: 2331-5717. 2015/11/21; updates online.
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  • [Title] 'Cramp Fasciculation Syndromes': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'cramp fasciculation syndromes'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 14 publications, and group two 52 publications.
  • Here are the top 8.
  • Liewluck T et al: Cramp-fasciculation syndrome in patients with and without neural autoantibodies.
  • Lagueny A: [Cramp-fasciculation syndrome].
  • Jansen PH et al: Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population.
  • de Entrambasaguas M et al: Bronchial involvement in the cramp-fasciculation syndrome.
  • Vos PE et al: [Muscle cramps and fasciculations not always ominous: muscle cramp-fasciculation syndrome].
  • de Carvalho M et al: Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?.
  • Nance CS et al: Later-onset Fabry disease: an adult variant presenting with the cramp-fasciculation syndrome.
  • Braune S et al: Involvement of the esophagus in the cramp-fasciculation syndrome.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710496107.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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49. 'Benign Fasciculat Cramp Syndr': Top Publications. BioMedLib Review OC; ;BenignFasciculatCramp:710496094. ISSN: 2331-5717. 2015/1/21; updates online.
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  • [Title] 'Benign Fasciculat Cramp Syndr': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'benign fasciculat cramp syndr'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 14 publications, and group two 49 publications.
  • Here are the top 8.
  • Liewluck T et al: Cramp-fasciculation syndrome in patients with and without neural autoantibodies.
  • Lagueny A: [Cramp-fasciculation syndrome].
  • Jansen PH et al: Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population.
  • Nance CS et al: Later-onset Fabry disease: an adult variant presenting with the cramp-fasciculation syndrome.
  • Vos PE et al: [Muscle cramps and fasciculations not always ominous: muscle cramp-fasciculation syndrome].
  • de Carvalho M et al: Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?.
  • de Entrambasaguas M et al: Bronchial involvement in the cramp-fasciculation syndrome.
  • Braune S et al: Involvement of the esophagus in the cramp-fasciculation syndrome.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710496094.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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50. Einollahi B, Motalebi M, Rostami Z, Nemati E, Salesi M: Sleep quality among Iranian hemodialysis patients: a multicenter study. Nephrourol Mon; 2015 Jan;7(1):e23849
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Sleep disorders are prevalent complication in patients with end-stage renal disease undergoing hemodialysis (HD).
  • Sleep domain of disease specific core of KDCS-SF questionnaire and generic core of this questionnaire (SF-36) were used to assess patients' SQ and quality of life (QoL), respectively.
  • In logistic regression analysis, there were significant correlation between good SQ and younger age, shorter dialysis vintage, less muscle cramp, high QoL, high cognitive function score, and high sexual function.

  • ResearchGate. author profiles.
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  • (PMID = 25738125.001).
  • [ISSN] 2251-7006
  • [Journal-full-title] Nephro-urology monthly
  • [ISO-abbreviation] Nephrourol Mon
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC4330687
  • [Keywords] NOTNLM ; Hospitalization / Quality of Life / Questionnaire / Sleep
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