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1. Biomedical articles (top 50; 2010 to 2015)
1. Leão RN, Barreto P, Leão RR, Ribeiro JV: Nitrofurantoin: cause of DRESS syndrome. BMJ Case Rep; 2013;2013
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin: cause of DRESS syndrome.
  • Nitrofurantoin is a commonly used antibacterial drug because it has low side effects and a good antiurinary bacterial profile.
  • However, in this paper, we present a case of a nitrofurantoin-induced DRESS (drug reaction/rash with eosinophilia and systemic symptoms) syndrome in a 77-year-old woman.
  • At the emergency department, we found her developing eosinophilic pneumonia, anaemia and renal impairment that we relate to nitrofurantoin administration.
  • To our knowledge, this is the second published case report which evokes nitrofurantoin as a possible cause of DRESS syndrome.
  • [MeSH-major] Anti-Bacterial Agents / adverse effects. Drug Hypersensitivity Syndrome / etiology. Nitrofurantoin / adverse effects. Urinary Tract Infections / drug therapy

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  • (PMID = 23661654.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 927AH8112L / Nitrofurantoin
  • [Other-IDs] NLM/ PMC3669827
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2. Madani Y, Mann B: Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections. Prim Care Respir J; 2012 Sep;21(3):337-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections.
  • Nitrofurantoin is commonly used for the treatment and prophylaxis of recurrent urinary tract infections (UTIs).
  • Although relatively rare, nitrofurantoin is one of the commonest causes of drug-induced pulmonary disease, which can be potentially serious and even fatal.
  • Patients on long-term nitrofurantoin should be reviewed and monitored regularly.
  • We report three cases of nitrofurantoin-induced lung disease in patients who were on long-term nitrofurantoin for UTI prophylaxis and present a brief review of the literature on this subject.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Lung Diseases / chemically induced. Nitrofurantoin / adverse effects

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  • [CommentIn] J Urol. 2013 Oct;190(4):1252 [24029321.001]
  • (PMID = 22836745.001).
  • [ISSN] 1475-1534
  • [Journal-full-title] Primary care respiratory journal : journal of the General Practice Airways Group
  • [ISO-abbreviation] Prim Care Respir J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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3. Zao J, Koren G, Bozzo P: Using nitrofurantoin while breastfeeding a newborn. Can Fam Physician; 2014 Jun;60(6):539-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Using nitrofurantoin while breastfeeding a newborn.
  • Is nitrofurantoin a safe antibiotic for treatment?
  • ANSWER: The use of nitrofurantoin in breastfeeding mothers is generally safe, as only small amounts transfer into the breast milk.
  • Despite the lack of documented reports, there is a risk of hemolytic anemia in all newborns exposed to nitrofurantoin owing to their glutathione instability, especially in infants with glucose-6-phosphate dehydrogenase deficiency.
  • Although some suggest that nitrofurantoin be avoided in infants younger than 1 month, studies have noted that glutathione stability might be established by the eighth day of life.
  • In infants younger than 1 month, an alternative antibiotic might be preferred; however, if an alternative were not available, the use of nitrofurantoin would not be a reason to avoid breastfeeding.

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  • [Copyright] Copyright© the College of Family Physicians of Canada.
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  • (PMID = 24925943.001).
  • [ISSN] 1715-5258
  • [Journal-full-title] Canadian family physician Médecin de famille canadien
  • [ISO-abbreviation] Can Fam Physician
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC4055319
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4. Xavier BB, Vervoort J, Stewardson A, Adriaenssens N, Coenen S, Harbarth S, Goossens H, Malhotra-Kumar S: Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains. Genome Announc; 2014;2(2)
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  • [Title] Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains.
  • Widespread multidrug resistance in Escherichia coli has necessitated the reintroduction of older antibiotics, such as nitrofurantoin.
  • However, mechanisms by which resistance to nitrofurantoin emerges in E. coli are not well elucidated.
  • Toward this aim, we sequenced two nitrofurantoin-sensitive E. coli sequence types (ST540 and ST2747) and their four nitrofurantoin-resistant derivatives generated in vitro under aerobic and anaerobic growth conditions.


5. Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Nitrofurantoin Toxicity': Top Publications. BioMedLib Review; OrganicChemical;NitrofurantoinToxicity:705789211. ISSN: 2331-5717. 2014/7/30
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  • [Title] 'Organic Chemicals' associated with 'Nitrofurantoin Toxicity': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organic Chemical' for 'nitrofurantoin toxicity'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organic Chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 133 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Nitrofurantoin Toxicity': Top Publications.
  • Weir M et al: Lung toxicity and Nitrofurantoin: the tip of the iceberg?.
  • Adam A et al: An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.
  • Peall AF et al: Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report.
  • Bialas MC et al: Nitrofurantoin rechallenge and recurrent toxicity.
  • Linnebur SA et al: Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
  • Reinhart HH et al: Combined nitrofurantoin toxicity to liver and lung.
  • Dam-Larsen S et al: [Hepatic toxicity of nitrofurantoin. Cases reported to the Center for Monitoring Adverse Drug Reactions 1968-1998].
  • Sengupta S et al: DNA damage and prophage induction and toxicity of nitrofurantoin in Escherichia coli and Vibrio cholerae cells.
  • Kiang TK et al: Nitrofurantoin-associated lung and liver toxicity leading to liver transplantation in a middle-aged patient.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705789211.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. Singh A, Singh P, Sidhu US: Reversible interstitial lung disease with prolonged use of nitrofurantoin: Do the benefits outweigh the risks? Lung India; 2013 Jul;30(3):212-4
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  • [Title] Reversible interstitial lung disease with prolonged use of nitrofurantoin: Do the benefits outweigh the risks?
  • We describe the case summary of a 70-year-old man diagnosed with interstitial lung disease due to prolonged nitrofurantoin therapy.
  • Despite honeycombing confirmed by computed tomography of the thorax, symptoms and radiographic findings disappeared within 1 month after withdrawal of nitrofurantoin.
  • The case highlights the fact that nitrofurantoin-induced lung disease may run a benign course and respond favorably despite radiographic evidence of established lung fibrosis (honey combing).

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  • (PMID = 24049258.001).
  • [ISSN] 0970-2113
  • [Journal-full-title] Lung India : official organ of Indian Chest Society
  • [ISO-abbreviation] Lung India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3775203
  • [Keywords] NOTNLM ; Interstitial pneumonia / nitrofurantoin / pleural effusion / pulmonary fibrosis
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7. Babakir-Mina M, Othman N, Najmuldeen HH, Noori CK, Fatah CF, Perno CF, Ciotti M: Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan. New Microbiol; 2012 Oct;35(4):439-46
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  • [Title] Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan.
  • Furthermore there was a significant association between age and antibiotic resistance for all antibiotics except for vancomycin and nitrofurantoin.
  • [MeSH-major] Anti-Bacterial Agents / pharmacology. Burns / microbiology. Nitrofurantoin / pharmacology. Staphylococcal Infections / microbiology. Staphylococcus aureus / drug effects. Vancomycin / pharmacology


8. Namagondlu G, Low SE, Seneviratne R, Banerjee A: Acute renal failure from nitrofurantoin-induced acute granulomatous interstitial nephritis. QJM; 2010 Jan;103(1):49-52
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  • [Title] Acute renal failure from nitrofurantoin-induced acute granulomatous interstitial nephritis.
  • We report here a case of acute renal failure with nitrofurantoin-associated acute granulomatous interstitial nephritis (GIN), which was commenced as a long-term prophylactic agent for suspected recurrent urinary tract infections.
  • All new medication changes should be held in suspicion as a cause of acute onset abnormalities in serum biochemistry.
  • [MeSH-major] Acute Kidney Injury / etiology. Anti-Infective Agents, Urinary / adverse effects. Granuloma / chemically induced. Nephritis, Interstitial / chemically induced. Nitrofurantoin / adverse effects

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  • (PMID = 19828642.001).
  • [ISSN] 1460-2393
  • [Journal-full-title] QJM : monthly journal of the Association of Physicians
  • [ISO-abbreviation] QJM
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin; AYI8EX34EU / Creatinine
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9. Mullerpattan JB, Dagaonkar RS, Shah HD, Udwadia ZF: Fatal nitrofurantoin lung. J Assoc Physicians India; 2013 Oct;61(10):758-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fatal nitrofurantoin lung.
  • Nitrofurantoin is a drug commonly used for urinary tract infections.
  • We present a case of an elderly lady receiving nitrofurantoin for her urinary tract infection who developed sudden acute lung injury to which she finally succumbed within a few weeks.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Lung Diseases, Interstitial / chemically induced. Lung Diseases, Interstitial / diagnosis. Nitrofurantoin / adverse effects

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  • (PMID = 24772739.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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10. Hardak E, Berger G, Krivoy N, Solomonov A, Yigla M: Nitrofurantoin pulmonary toxicity: neglected threat. Curr Drug Saf; 2010 Apr;5(2):125-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin pulmonary toxicity: neglected threat.
  • Nitrofurantoin lung toxicity was diagnosed among ten patients receiving 50 mg/day to prevent recurrent urinary tract infection.
  • Large amount of data regarding unexpected, sometimes severe pulmonary toxicity during nitrofurantoin therapy should maintain a high index of suspicion for the drug usage among patients with non-resolving pulmonary symptoms.
  • [MeSH-major] Lung Diseases / chemically induced. Lung Diseases / diagnosis. Nitrofurantoin / adverse effects

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  • (PMID = 19534638.001).
  • [ISSN] 2212-3911
  • [Journal-full-title] Current drug safety
  • [ISO-abbreviation] Curr Drug Saf
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United Arab Emirates
  • [Chemical-registry-number] 0 / Steroids; 927AH8112L / Nitrofurantoin
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11. Tan IL, Polydefkis MJ, Ebenezer GJ, Hauer P, McArthur JC: Peripheral nerve toxic effects of nitrofurantoin. Arch Neurol; 2012 Feb;69(2):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Peripheral nerve toxic effects of nitrofurantoin.
  • OBJECTIVE: To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy.
  • DESIGN: We describe the clinical features and skin biopsies of 2 cases of non-length-dependent small-fiber neuropathy/ganglionopathy attributable to nitrofurantoin.
  • CONCLUSIONS: These distinct morphologic changes associated with nitrofurantoin have not been previously reported to our knowledge.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Nitrofurantoin / adverse effects. Peripheral Nervous System Diseases / chemically induced. Peripheral Nervous System Diseases / pathology


12. Stock I: [Nitrofurantoin--clinical relevance in uncomplicated urinary tract infections]. Med Monatsschr Pharm; 2014 Jul;37(7):242-8
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  • [Title] [Nitrofurantoin--clinical relevance in uncomplicated urinary tract infections].
  • [Transliterated title] Nitrofurantoin-- Stellenwert bei unkomplizierten Harnwegsinfektionen.
  • The nitrofuran derivative nitrofurantoin has been used for more than 60 years for the antibacterial therapy of uncomplicated urinary tract infections (UTI).
  • Nitrofurantoin therapy has been shown to be accompanied by numerous adverse drug effects.
  • Recent studies, however, have shown a good efficacy and tolerability of short-term nitrofurantoin therapy comparable to previous established standard therapeutic regimens applying cotrimoxazole or quinolones.
  • In many current treatment guidelines, e. g., the international clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women published by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases, nitrofurantoin has been recommended as one first-line antibiotic of empiric antibacterial treatment of uncomplicated cystitis in otherwise healthy women.
  • In Germany, however, nitrofurantoin should only be applied if more effective and less risky antibiotics cannot be used.
  • Nitrofurantoin is contraindicated in the last three months of pregnancy and in patients suffering from renal impairment of each degree.
  • Despite compatibility concerns, nitrofurantoin has also been recommended for the re-infection prophylaxis of recurrent uncomplicated urinary tract infections in Germany and several other countries.
  • [MeSH-major] Anti-Infective Agents, Urinary / therapeutic use. Nitrofurantoin / therapeutic use. Urinary Tract Infections / drug therapy

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  • (PMID = 25065160.001).
  • [ISSN] 0342-9601
  • [Journal-full-title] Medizinische Monatsschrift für Pharmazeuten
  • [ISO-abbreviation] Med Monatsschr Pharm
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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13. Aracena P, Lazo-Hernández C, Molina-Berríos A, Sepúlveda DR, Reinoso C, Larraín JI, Navarro J, Letelier ME: Microsomal oxidative stress induced by NADPH is inhibited by nitrofurantoin redox biotranformation. Free Radic Res; 2014 Feb;48(2):129-36
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  • [Title] Microsomal oxidative stress induced by NADPH is inhibited by nitrofurantoin redox biotranformation.
  • Nitrofurantoin is used in the antibacterial therapy of the urinary tract.
  • Diverse studies show that the nitro reductive metabolism of nitrofurantoin leads to ROS generation.
  • Oxidative stress arising from this nitro reductive metabolism has been proposed as the mechanism underlying the adverse effects associated with nitrofurantoin.
  • There is, however, an apparent paradox between these findings and the ability of nitrofurantoin to inhibit lipid peroxidation provoked by NADPH in rat liver microsomes.
  • Our results show that microsomal lipid peroxidation promoted by NADPH is inhibited by nitrofurantoin in a concentration-dependent manner.
  • This suggests that the consumption of NADPH in microsomes can be competitively promoted by lipid peroxidation and nitrofurantoin metabolism.
  • The incubation of microsomes with NADPH and nitrofurantoin generated 1-aminohidantoin.
  • In addition, the biotransformation of a classical substrate of CYP450 oxidative system was competitively inhibited by nitrofurantoin.
  • These results suggest that nitrofurantoin is metabolized through CYP450 system.
  • Data are discussed in terms of the in vitro redox metabolism of nitrofurantoin.
  • [MeSH-major] Anti-Infective Agents, Urinary / metabolism. Microsomes, Liver / metabolism. NADP / physiology. Nitrofurantoin / metabolism. Oxidative Stress

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  • (PMID = 23967899.001).
  • [ISSN] 1029-2470
  • [Journal-full-title] Free radical research
  • [ISO-abbreviation] Free Radic. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 1-aminohydantoin; 0 / Anti-Infective Agents, Urinary; 0 / Hydantoins; 53-59-8 / NADP; 9035-51-2 / Cytochrome P-450 Enzyme System; 927AH8112L / Nitrofurantoin
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14. Broes MJ, Roelofs BF, Mudde AH, Hoornenborg E: [Pulmonary toxicity resulting from the use of nitrofurantoin]. Ned Tijdschr Geneeskd; 2012;156(44):A4990
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Pulmonary toxicity resulting from the use of nitrofurantoin].
  • Acute pulmonary syndrome is an uncommon but severe adverse reaction to nitrofurantoin.
  • This syndrome is seldom recognised at the moment of presentation, which potentially subjects patients to unnecessary treatment and delays in the discontinuation of nitrofurantoin.
  • We discuss the case histories of an 80-year-old and an 81-year-old woman, each presenting with acute pulmonary syndrome after nitrofurantoin administration.
  • The diagnosis of acute pulmonary syndrome should be considered in patients presenting with fever, dyspnoea, dry cough, leukocytosis (typically with eosinophilia) and a bilateral interstitial pattern visible on the chest X-ray after having started nitrofurantoin.
  • The prognosis is excellent if the condition is recognised early and the exposure to nitrofurantoin is discontinued.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Lung Diseases / chemically induced. Lung Diseases / diagnosis. Nitrofurantoin / adverse effects

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  • (PMID = 23114172.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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15. Nordeng H, Lupattelli A, Romøren M, Koren G: Neonatal outcomes after gestational exposure to nitrofurantoin. Obstet Gynecol; 2013 Feb;121(2 Pt 1):306-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neonatal outcomes after gestational exposure to nitrofurantoin.
  • OBJECTIVE: To estimate whether first-trimester exposure to nitrofurantoin is associated with increased malformation rates and, secondarily, to estimate whether exposure to nitrofurantoin is associated with increased rates of negative pregnancy outcomes and perinatal complications.
  • The pregnancy outcomes of women who were dispensed nitrofurantoin during pregnancy were compared with the outcomes of women who were dispensed pivmecillinam (disease comparison group) and unexposed women.
  • RESULTS: In all, 5,794 (3.2%) filled prescriptions for nitrofurantoin during pregnancy, 1,334 women (0.7%) in the first trimester and 979 women (0.5%) in the last 4 weeks of pregnancy.
  • Dispensing nitrofurantoin during the first trimester was not associated with increased risk of major malformations (31 of 1,334 [2.3%]) compared with disease controls (162 of 5,800 [2.8%], odds ratio [OR] 0.79, 95% confidence interval [CI] 0.51-1.23).
  • Dispensing nitrofurantoin the last 30 days before delivery was associated with increased risk of neonatal jaundice (103 of 959 [10.8%]) compared with unexposed women (10,336 of 127,507 [8.1%], OR 1.31, 95% CI 1.02-1.70).
  • CONCLUSION: The results from this large, population-based study suggest that the teratogenic potential of nitrofurantoin is low.
  • [MeSH-major] Abnormalities, Drug-Induced / etiology. Anti-Infective Agents, Urinary / adverse effects. Infant, Newborn, Diseases / chemically induced. Nitrofurantoin / adverse effects. Prenatal Exposure Delayed Effects / chemically induced


16. Murie J, Agarwal M: Sub-acute cutaneous lupus erythematosus following nitrofurantoin: causative or coincidental? Scott Med J; 2014 Nov;59(4):e21-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sub-acute cutaneous lupus erythematosus following nitrofurantoin: causative or coincidental?
  • Three months earlier, she had been prescribed six months prophylactic nitrofurantoin for recurrent urinary tract infections, treated with nitrofurantoin and trimethoprim.
  • Nitrofurantoin is associated with many side effects and hypersensitivity reactions.
  • Possible drug-induced lupus reactions due to nitrofurantoin include pneumonitis, blood disorders and hepatotoxicity.
  • This is the only published case of isolated sub-acute cutaneous lupus following maintenance nitrofurantoin.

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  • [Copyright] © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
  • (PMID = 25348483.001).
  • [ISSN] 0036-9330
  • [Journal-full-title] Scottish medical journal
  • [ISO-abbreviation] Scott Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
  • [Keywords] NOTNLM ; Systemic lupus erythematosus / drug-induced lupus / nitrofurantoin / sub-acute cutaneous lupus erythematosus
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17. Komp Lindgren P, Klockars O, Malmberg C, Cars O: Pharmacodynamic studies of nitrofurantoin against common uropathogens. J Antimicrob Chemother; 2015 Apr;70(4):1076-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pharmacodynamic studies of nitrofurantoin against common uropathogens.
  • OBJECTIVES: To determine the pharmacokinetic/pharmacodynamic index that best correlates to nitrofurantoin's antibacterial effect, we studied nitrofurantoin activity against common causative pathogens in uncomplicated urinary tract infection (UTI).
  • The MICs of nitrofurantoin were determined by Etest.
  • Time-kill curves with different concentrations of nitrofurantoin (based on multiples of isolate-specific MICs) were followed over 24 h.
  • An in vitro kinetic model was used to simulate different time-concentration profiles, exposing E. coli to nitrofurantoin for varying proportions of the dosing interval.
  • In the kinetic model, the effect of nitrofurantoin on E. coli displayed a 4 log reduction in cfu/mL within 6 h at 8 × MIC.
  • CONCLUSIONS: Nitrofurantoin was highly effective against E. coli and S. saprophyticus isolates; the killing effect against E. faecium was not as rapid, but still significant.
  • Against E. coli, nitrofurantoin was mainly associated with a concentration-dependent action; this was confirmed in the kinetic model, in which T>MIC displayed the best correlation.

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  • [Copyright] © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
  • (PMID = 25515669.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Keywords] NOTNLM ; PD / UTIs / urinary tract infections
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18. Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Nitrofurantoin Susceptibility': Top Publications. BioMedLib Review; OrganicChemical;NitrofurantoinSusceptibility:705729237. ISSN: 2331-5717. 2014/10/30
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  • [Title] 'Organic Chemicals' associated with 'Nitrofurantoin Susceptibility': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organic Chemical' for 'nitrofurantoin susceptibility'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organic Chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 582 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Nitrofurantoin Susceptibility': Top Publications.
  • Hoo R et al: Potential unreliability of nitrofurantoin disks in susceptibility testing.
  • Karlowsky JA et al: Susceptibility of antimicrobial-resistant urinary Escherichia coli isolates to fluoroquinolones and nitrofurantoin.
  • Babakir-Mina M et al: Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan.
  • Anklesaria P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim--nitrofurantoin combination.
  • Obaseiki-Ebor EE: Enhanced Escherichia coli susceptibility to nitrofurantoin by EDTA and multiple aminoglycoside antibiotics resistance mutation.
  • Jasińska B et al: [Susceptibility to nitrofurantoin, biseptol and nalidixic acid of E. coli strains isolated from urine in the years 1983-1990].
  • SCHNEIERSON SS: 1959 bacterial susceptibility to nitrofurantoin as compared to 1953 to 1955.
  • Barry AL: Nitrofurantoin susceptibility test criteria.
  • Patil P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim-nitrofuratoin combination.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705729237.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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19. Cooper IF, Siadaty MS: 'Pharmacologic Substances' associated with 'Nitrofurantoin Susceptibility': Top Publications. BioMedLib Review; PharmacologicSubstance;NitrofurantoinSusceptibility:706670488. ISSN: 2331-5717. 2014/7/30
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  • [Title] 'Pharmacologic Substances' associated with 'Nitrofurantoin Susceptibility': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Pharmacologic Substance' for 'nitrofurantoin susceptibility'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Pharmacologic Substance'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 588 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Nitrofurantoin Susceptibility': Top Publications.
  • Karlowsky JA et al: Susceptibility of antimicrobial-resistant urinary Escherichia coli isolates to fluoroquinolones and nitrofurantoin.
  • Hoo R et al: Potential unreliability of nitrofurantoin disks in susceptibility testing.
  • Babakir-Mina M et al: Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan.
  • Anklesaria P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim--nitrofurantoin combination.
  • Obaseiki-Ebor EE: Enhanced Escherichia coli susceptibility to nitrofurantoin by EDTA and multiple aminoglycoside antibiotics resistance mutation.
  • SCHNEIERSON SS: 1959 bacterial susceptibility to nitrofurantoin as compared to 1953 to 1955.
  • Jasińska B et al: [Susceptibility to nitrofurantoin, biseptol and nalidixic acid of E. coli strains isolated from urine in the years 1983-1990].
  • Barry AL: Nitrofurantoin susceptibility test criteria.
  • Patil P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim-nitrofuratoin combination.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706670488.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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20. Cooper IF, Siadaty MS: 'Pharmacologic Substances' associated with 'Nitrofurantoin Toxicity': Top Publications. BioMedLib Review; PharmacologicSubstance;NitrofurantoinToxicity:706691640. ISSN: 2331-5717. 2014/11/30
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  • [Title] 'Pharmacologic Substances' associated with 'Nitrofurantoin Toxicity': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Pharmacologic Substance' for 'nitrofurantoin toxicity'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Pharmacologic Substance'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 135 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Nitrofurantoin Toxicity': Top Publications.
  • Weir M et al: Lung toxicity and Nitrofurantoin: the tip of the iceberg?.
  • Adam A et al: An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.
  • Peall AF et al: Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report.
  • Bialas MC et al: Nitrofurantoin rechallenge and recurrent toxicity.
  • Linnebur SA et al: Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
  • Reinhart HH et al: Combined nitrofurantoin toxicity to liver and lung.
  • Dam-Larsen S et al: [Hepatic toxicity of nitrofurantoin. Cases reported to the Center for Monitoring Adverse Drug Reactions 1968-1998].
  • Sengupta S et al: DNA damage and prophage induction and toxicity of nitrofurantoin in Escherichia coli and Vibrio cholerae cells.
  • Kiang TK et al: Nitrofurantoin-associated lung and liver toxicity leading to liver transplantation in a middle-aged patient.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706691640.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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21. Tutughamiarso M, Bolte M, Wagner G, Egert E: Five pseudopolymorphs and a cocrystal of nitrofurantoin. Acta Crystallogr C; 2011 Jan;67(Pt 1):o18-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Five pseudopolymorphs and a cocrystal of nitrofurantoin.
  • The antibiotic nitrofurantoin {systematic name: (E)-1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione} is not only used for the treatment of urinary tract infections, but also illegally applied as an animal food additive.
  • Since derivatives of 2,6-diaminopyridine might serve as artificial receptors for its recognition, we crystallized one potential drug-receptor complex, nitrofurantoin-2,6-diacetamidopyridine (1/1), C(8)H(6)N(4)O(5)·C(9)H(11)N(3)O(2), (I·II).
  • During the crystallization screening, several new pseudopolymorphs of both components were obtained, namely a nitrofurantoin dimethyl sulfoxide monosolvate, C(8)H(6)N(4)O(5)·C(2)H(6)OS, (Ia), a nitrofurantoin dimethyl sulfoxide hemisolvate, C(8)H(6)N(4)O(5)·0.5C(2)H(6)OS, (Ib), two nitrofurantoin dimethylacetamide monosolvates, C(8)H(6)N(4)O(5)·C(4)H(9)NO, (Ic) and (Id), and a nitrofurantoin dimethylacetamide disolvate, C(8)H(6)N(4)O(5)·2C(4)H(9)NO, (Ie), as well as a 2,6-diacetamidopyridine dimethylformamide monosolvate, C(9)H(11)N(3)O(2)·C(3)H(7)NO, (IIa).
  • Obviously nitrofurantoin prefers the higher-energy conformation in the crystal structures, which all exhibit N-H···O and C-H···O hydrogen-bond interactions.
  • [MeSH-major] Nitrofurantoin / chemistry

  • HSDB. structure - NITROFURANTOIN.
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  • (PMID = 21206078.001).
  • [ISSN] 1600-5759
  • [Journal-full-title] Acta crystallographica. Section C, Crystal structure communications
  • [ISO-abbreviation] Acta Crystallogr C
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 927AH8112L / Nitrofurantoin
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22. Patel DS, Sharma N, Patel MC, Patel BN, Shrivastav PS, Sanyal M: Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry. Acta Pharm; 2013 Jun;63(2):141-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry.
  • A reliable, selective and sensitive LC-MS/MS assay has been proposed for the determination of nitrofurantoin in human plasma.
  • Quantitation was done using the multiple reaction monitoring (MRM) mode for deprotonated precursor to product ion transitions of nitrofurantoin (m/z 237.0 → 151.8) and nitrofurazone (m/z 197.0 → 123.9).
  • The limit of detection and the lowest limit of quantitation of the method were 0.25 ng mL-1 and 5.00 ng mL-1, respectively, with a linear dynamic range of 5.00-1500 ng mL-1 for nitrofurantoin.
  • The method was successfully applied to a bioequivalence study of a 100 mg nitrofurantoin capsule formulation in 36 healthy subjects.
  • [MeSH-major] Chromatography, Liquid / methods. Nitrofurantoin. Nitrofurazone. Tandem Mass Spectrometry / methods

  • HSDB. structure - NITROFURAZONE.
  • HSDB. structure - NITROFURANTOIN.
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  • (PMID = 23846139.001).
  • [ISSN] 1846-9558
  • [Journal-full-title] Acta pharmaceutica (Zagreb, Croatia)
  • [ISO-abbreviation] Acta Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 0 / Capsules; 927AH8112L / Nitrofurantoin; X8XI70B5Z6 / Nitrofurazone
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23. Amábile-Cuevas CF, Arredondo-García JL: Nitrofurantoin, phenazopyridine, and the superoxide-response regulon soxRS of Escherichia coli. J Infect Chemother; 2013 Dec;19(6):1135-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin, phenazopyridine, and the superoxide-response regulon soxRS of Escherichia coli.
  • Nitrofurantoin and phenazopyridine are two drugs commonly used against urinary tract infections.
  • This study was done to assess the interactions of these drugs with the soxRS regulon of Escherichia coli, a superoxide-defense system (that includes a nitroreductase that yields the active metabolite of nitrofurantoin) involved in antibiotic multi-resistance.
  • The effects of either nitrofurantoin or phenazopyridine, upon strains with different soxRS genotypes, were measured as minimum inhibitory concentrations (MICs) and growth curves.
  • A strain constitutively expressing the soxRS regulon was slightly more susceptible to nitrofurantoin, and more resistant to phenazopyridine, compared to wild-type and soxRS-deleted strains, during early treatment, but 24-h MICs were the same (8 mg/l nitrofurantoin, 1,000 mg/l phenazopyridine) for all strains.
  • Subinhibitory concentrations of phenazopyridine increased the antimicrobial effect of ampicillin, chloramphenicol, tetracycline, and nitrofurantoin.
  • The induction or constitutive expression of the soxRS regulon seems to be a disadvantage for E. coli during nitrofurantoin exposure; but might be an advantage during phenazopyridine exposure, indicating that the latter compound could act as a selective pressure for mutations related to virulence and antibiotic multi-resistance.
  • [MeSH-major] Anti-Bacterial Agents / pharmacology. Bacterial Proteins / metabolism. Escherichia coli / drug effects. Escherichia coli Proteins / metabolism. Nitrofurantoin / pharmacology. Phenazopyridine / pharmacology. Regulon / drug effects. Trans-Activators / metabolism. Transcription Factors / metabolism

  • MedlinePlus Health Information. consumer health - Antibiotics.
  • HSDB. structure - NITROFURANTOIN.
  • HSDB. structure - PHENAZOPYRIDINE.
  • ResearchGate. author profiles.
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  • (PMID = 23793794.001).
  • [ISSN] 1437-7780
  • [Journal-full-title] Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • [ISO-abbreviation] J. Infect. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Bacterial Proteins; 0 / Escherichia coli Proteins; 0 / Trans-Activators; 0 / Transcription Factors; 137804-81-0 / SoxR protein, Bacteria; 137804-82-1 / SoxS protein, E coli; 927AH8112L / Nitrofurantoin; K2J09EMJ52 / Phenazopyridine
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24. Milić R, Plavec G, Tufegdzić I, Tomić I, Sarac S, Loncarević O: Nitrofurantoin-induced immune-mediated lung and liver disease. Vojnosanit Pregl; 2012 Jun;69(6):536-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin-induced immune-mediated lung and liver disease.
  • INTRODUCTION: Nitrofurantoin, a furan derivative, introduced in the fifties has widely been used as an effective agent for the treatment and prevention of urinary tract infections (UTI).
  • Spectrum of adverse reactions to nitrofurantoin is wide, ranging from eosinophilic interstitial lung disease, acute hepatitis and granulomatous reaction, to the chronic active hepatitis, a very rare adverse effect, that can lead to cirrhosis and death.
  • CASE REPORT: We presented a 55-year- old female patient with eosinophilic interstitial lung disease, severe chronic active hepatitis and several other immune- mediated multisystemic manifestations of prolonged exposure to nitrofurantoin because of the recurrent UTI caused by Escherichia coli.
  • After withdrawal of nitrofurantoin and application of high dose of glicocorticosteroids, prompt clinical and laboratory recovery was achieved.
  • Consideration should be given to monitor lung and liver function tests during long term nitrofurantoin therapy.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Autoimmune Diseases / chemically induced. Drug-Induced Liver Injury / etiology. Lung Diseases / chemically induced. Nitrofurantoin / adverse effects


25. Cooper IF, Siadaty MS: 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Nitrofurantoin Toxicity': Top Publications. BioMedLib Review; PharmacologicSubstanceAntibiotic;NitrofurantoinToxicity:705492173. ISSN: 2331-5717. 2014/5/2
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  • [Title] 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Nitrofurantoin Toxicity': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'pharmacologic substance or antibiotic or clinical drug' for 'nitrofurantoin toxicity'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'pharmacologic substance or antibiotic or clinical drug'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 116 publications.
  • Here are the top 10.
  • Weir M et al: Lung toxicity and Nitrofurantoin: the tip of the iceberg?.
  • Peall AF et al: Concomitant pulmonary and hepatic toxicity secondary to nitrofurantoin: a case report.
  • Adam A et al: An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.
  • Bialas MC et al: Nitrofurantoin rechallenge and recurrent toxicity.
  • Kiang TK et al: Nitrofurantoin-associated lung and liver toxicity leading to liver transplantation in a middle-aged patient.
  • Linnebur SA et al: Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
  • Reinhart HH et al: Combined nitrofurantoin toxicity to liver and lung.
  • Hardak E et al: Nitrofurantoin pulmonary toxicity: neglected threat.
  • Suntres ZE et al: Nitrofurantoin-induced pulmonary toxicity. In vivo evidence for oxidative stress-mediated mechanisms.
  • Dam-Larsen S et al: [Hepatic toxicity of nitrofurantoin. Cases reported to the Center for Monitoring Adverse Drug Reactions 1968-1998].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705492173.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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26. Cherukuvada S, Babu NJ, Nangia A: Nitrofurantoin-p-aminobenzoic acid cocrystal: hydration stability and dissolution rate studies. J Pharm Sci; 2011 Aug;100(8):3233-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin-p-aminobenzoic acid cocrystal: hydration stability and dissolution rate studies.
  • Nitrofurantoin (NF) drug is known to transform to a hydrate form in aqueous medium.
  • [MeSH-major] 4-Aminobenzoic Acid / chemistry. Anti-Infective Agents, Urinary / chemistry. Nitrofurantoin / chemistry

  • HSDB. structure - 4-AMINOBENZOIC ACID.
  • HSDB. structure - UREA.
  • HSDB. structure - NITROFURANTOIN.
  • HSDB. structure - (L)-ARGININE.
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  • [Copyright] Copyright © 2011 Wiley-Liss, Inc.
  • (PMID = 21425165.001).
  • [ISSN] 1520-6017
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 059QF0KO0R / Water; 8W8T17847W / Urea; 927AH8112L / Nitrofurantoin; 94ZLA3W45F / Arginine; TL2TJE8QTX / 4-Aminobenzoic Acid
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27. Al-Zarouni M, Senok A, Al-Zarooni N, Al-Nassay F, Panigrahi D: Extended-spectrum β-lactamase-producing Enterobacteriaceae: in vitro susceptibility to fosfomycin, nitrofurantoin and tigecycline. Med Princ Pract; 2012;21(6):543-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extended-spectrum β-lactamase-producing Enterobacteriaceae: in vitro susceptibility to fosfomycin, nitrofurantoin and tigecycline.
  • OBJECTIVE: To assess the susceptibility trends of community-acquired extended-spectrum β-Iactamase (ESBL)-producing urinary isolates with particular reference to fosfomycin, nitrofurantoin and tigecycline.
  • The antibiotic sensitivity of ESBL-producing uropathogens to a panel of antibiotics including tigecycline, fosfomycin and nitrofurantoin was assessed.
  • Sensitivity to nitrofurantoin and fosfomycin was 90 and 100%, respectively.
  • Fosfomycin and nitrofurantoin were active against ESBL-positive uropathogens, and emergence of tigecycline resistance needs close monitoring.
  • [MeSH-minor] Chi-Square Distribution. Fosfomycin / pharmacology. Fosfomycin / therapeutic use. Genotype. Humans. Minocycline / analogs & derivatives. Minocycline / pharmacology. Minocycline / therapeutic use. Nitrofurantoin / pharmacology. Nitrofurantoin / therapeutic use. United Arab Emirates

  • MedlinePlus Health Information. consumer health - Antibiotics.
  • MedlinePlus Health Information. consumer health - Urinary Tract Infections.
  • HSDB. structure - MINOCYCLINE.
  • HSDB. structure - NITROFURANTOIN.
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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 22722224.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents, Urinary; 2N81MY12TE / Fosfomycin; 70JE2N95KR / tigecycline; 927AH8112L / Nitrofurantoin; FYY3R43WGO / Minocycline
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28. Sakaan SA, Twilla JD, Usery JB, Winton JC, Self TH: Nitrofurantoin-induced hepatotoxicity: a rare yet serious complication. South Med J; 2014 Feb;107(2):107-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin-induced hepatotoxicity: a rare yet serious complication.
  • Nitrofurantoin is a commonly prescribed antibiotic for the treatment of recurrent uncomplicated urinary tract infections.
  • Since its introduction into clinical practice, nitrofurantoin has been associated with various adverse effects, including hepatotoxicity.
  • Key search terms included "nitrofurantoin AND hepatotoxicity" as well as "nitrofurantoin AND hepatitis."
  • A broad spectrum of liver toxicity associated with nitrofurantoin use has been reported, ranging from acute hepatitis, granulomatous reaction, cholestasis, or autoimmune-mediated hepatitis to chronic active hepatitis that could lead to cirrhosis or death.
  • It has been postulated that prolonged exposure to nitrofurantoin, female sex, advanced age, and reduced renal function increase the risk of developing hepatotoxicity.
  • For the management of severe cases, corticosteroids have been used along with nitrofurantoin discontinuation.
  • Given the severity and seriousness of the adverse effect of hepatotoxicity, clinicians should weigh the risks and benefits of nitrofurantoin before initiating therapy, especially in long-term prophylaxis in high-risk patients.
  • Clinicians also should be well versed in recognizing and managing liver injury associated with nitrofurantoin.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Drug-Induced Liver Injury. Liver / drug effects. Nitrofurantoin / adverse effects. Urinary Tract Infections / drug therapy

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  • (PMID = 24926677.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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29. Cooper IF, Siadaty MS: 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Nitrofurantoin Susceptibility': Top Publications. BioMedLib Review; PharmacologicSubstanceAntibiotic;NitrofurantoinSusceptibility:705457937. ISSN: 2331-5717. 2014/4/30
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  • [Title] 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Nitrofurantoin Susceptibility': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'pharmacologic substance or antibiotic or clinical drug' for 'nitrofurantoin susceptibility'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'pharmacologic substance or antibiotic or clinical drug'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 17 publications, and group two 564 publications.
  • Here are the top 10.
  • Karlowsky JA et al: Susceptibility of antimicrobial-resistant urinary Escherichia coli isolates to fluoroquinolones and nitrofurantoin.
  • Babakir-Mina M et al: Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan.
  • Anklesaria P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim--nitrofurantoin combination.
  • Patil P et al: In vitro susceptibility of urinary pathogens to trimethoprim, nitrofurantoin and trimethoprim-nitrofuratoin combination.
  • Babakir-Mina M et al: Author response to laboratory detection of MRSA. Comment on "Antibiotic susceptibility of vancomyin and nitrofurantoin in Staphylococcus aureus isolated from burnt patients in Sulaimaniyah, Iraqi Kurdistan".
  • Hoo R et al: Potential unreliability of nitrofurantoin disks in susceptibility testing.
  • Obaseiki-Ebor EE: Enhanced Escherichia coli susceptibility to nitrofurantoin by EDTA and multiple aminoglycoside antibiotics resistance mutation.
  • Jasińska B et al: [Susceptibility to nitrofurantoin, biseptol and nalidixic acid of E. coli strains isolated from urine in the years 1983-1990].
  • Traub WH et al: Nonspecific resistance of Serratia marcescens against antimicrobial drugs. Resistance or decreased susceptibility of phenotypic variants against chloramphenicol, nalidixic acid, nitrofurantoin, sulfonamides and trimethoprim.
  • Al-Zarouni M et al: Extended-spectrum β-lactamase-producing Enterobacteriaceae: in vitro susceptibility to fosfomycin, nitrofurantoin and tigecycline.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705457937.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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30. de Lima-Neto P, Correia AN, Portela RR, Julião Mda S, Linhares-Junior GF, de Lima JE: Square wave voltammetric determination of nitrofurantoin in pharmaceutical formulations on highly boron-doped diamond electrodes at different boron-doping contents. Talanta; 2010 Mar 15;80(5):1730-6
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  • [Title] Square wave voltammetric determination of nitrofurantoin in pharmaceutical formulations on highly boron-doped diamond electrodes at different boron-doping contents.
  • The influence of the boron-doping levels in boron-doped diamond film electrodes on the electrochemical response of nitrofurantoin (NFT) and the development of an electroanalytical procedure for NFT determination were investigated.
  • [MeSH-major] Anti-Infective Agents, Urinary / analysis. Boron / chemistry. Electrochemistry / methods. Nitrofurantoin / analysis

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  • [Copyright] Copyright (c) 2009 Elsevier B.V. All rights reserved.
  • (PMID = 20152404.001).
  • [ISSN] 1873-3573
  • [Journal-full-title] Talanta
  • [ISO-abbreviation] Talanta
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 7782-40-3 / Diamond; 927AH8112L / Nitrofurantoin; N9E3X5056Q / Boron
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31. Kang XS, Hou DB, Zhang GX, Chen XA, Yue FH, Huang PJ, Zhou ZK: [Spectral analysis of nitrofurantoin in the terahertz frequency range]. Guang Pu Xue Yu Guang Pu Fen Xi; 2012 Jul;32(7):1744-7
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  • [Title] [Spectral analysis of nitrofurantoin in the terahertz frequency range].
  • The present article measured the absorption coefficient spectra and refractive index spectra of nitrofurantoin original drug, which is one kind of nitrofuran drugs, in the terahertz frequency range from 0.2 to 1.8 THz using terahertz time-domain spectroscopy.
  • The results showed that there exist a number of characteristic absorption peaks of nitrofurantoin with different intensity in the range and the absorption coefficient spectra can be used to identify nitrofurantoin.
  • The article also simulated absorption coefficient spectra of nitrofurantoin molecule within 0.2 - 1.8 THz using density functional theory by Gaussian software, and vibrational modes of some peaks in the experimental absorption coefficient spectra were analyzed and identified.
  • The results show that the experimental absorption peaks at 1.25 and 1.60 THz correspond with the theoretical peaks at 1.30 and 1.67 THz, and these experimental peaks were caused by intramolecular vibrational modes of nitrofurantoin.

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  • (PMID = 23016316.001).
  • [ISSN] 1000-0593
  • [Journal-full-title] Guang pu xue yu guang pu fen xi = Guang pu
  • [ISO-abbreviation] Guang Pu Xue Yu Guang Pu Fen Xi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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32. Koradia V, de Diego HL, Elema MR, Rantanen J: Integrated approach to study the dehydration kinetics of nitrofurantoin monohydrate. J Pharm Sci; 2010 Sep;99(9):3966-76
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  • [Title] Integrated approach to study the dehydration kinetics of nitrofurantoin monohydrate.
  • The present study was aimed at gaining a mechanistic understanding of the dehydration of nitrofurantoin monohydrate II (NF-MH).
  • [MeSH-major] Anti-Infective Agents, Urinary / chemistry. Nitrofurantoin / chemistry. Water / chemistry

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  • (PMID = 20575054.001).
  • [ISSN] 1520-6017
  • [Journal-full-title] Journal of pharmaceutical sciences
  • [ISO-abbreviation] J Pharm Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 059QF0KO0R / Water; 927AH8112L / Nitrofurantoin
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33. Maaland M, Guardabassi L: In vitro antimicrobial activity of nitrofurantoin against Escherichia coli and Staphylococcus pseudintermedius isolated from dogs and cats. Vet Microbiol; 2011 Aug 5;151(3-4):396-9
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  • [Title] In vitro antimicrobial activity of nitrofurantoin against Escherichia coli and Staphylococcus pseudintermedius isolated from dogs and cats.
  • Minimum inhibitory concentrations (MIC) of nitrofurantoin were determined by agar dilution in 269 canine and feline isolates of Escherichia coli and Staphylococcus pseudintermedius, two of the most common bacterial species associated with urinary tract infection (UTI) in small animals.
  • All isolates, including multidrug-resistant strains of known genetic background, displayed MICs below the drug concentrations reported in canine urine following oral administration of nitrofurantoin.
  • Preliminary data on mutant prevention concentration (MPC) and many years of nitrofurantoin usage in human medicine suggest that emergence of resistant mutants during treatment is not a critical issue for this drug.
  • The study provides species-specific data on nitrofurantoin MIC distribution that can be used for setting dog- and cat-specific breakpoints.
  • Although nitrofurantoin is not an appropriate first-line agent for empirical treatment of canine UTI due to toxicity and poor pharmacokinetic properties, it may be indicated for treatment of UTI caused by multidrug-resistant bacteria, which are otherwise difficult to treat using conventional veterinary antimicrobial agents.
  • [MeSH-major] Anti-Infective Agents / pharmacology. Escherichia coli / drug effects. Nitrofurantoin / pharmacology. Staphylococcus / drug effects

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  • [Copyright] Copyright © 2011. Published by Elsevier B.V.
  • (PMID = 21482044.001).
  • [ISSN] 1873-2542
  • [Journal-full-title] Veterinary microbiology
  • [ISO-abbreviation] Vet. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Infective Agents; 927AH8112L / Nitrofurantoin
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34. Goldberg O, Koren G, Landau D, Lunenfeld E, Matok I, Levy A: Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations. J Clin Pharmacol; 2013 Sep;53(9):991-5
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  • [Title] Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations.
  • Antibacterial drugs are among the most common medications used by pregnant women.
  • While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nitrofurantoin during the first trimester of pregnancy have recently surfaced.
  • Associations between exposure to nitrofurantoin during the first trimester and major malformations were assessed.
  • A total of 1,329 infants and abortuses had been exposed to nitrofurantoin during the first trimester of pregnancy.
  • Exposure to nitrofurantoin was not associated with increased risk of major malformations in general (adjusted OR = 0.85, 95% CI 0.67-1.08) or with specific malformations.
  • First trimester exposure to nitrofurantoin was not associated with increased risk for total major congenital malformations or with specific malformations.
  • [MeSH-major] Abnormalities, Drug-Induced / epidemiology. Anti-Infective Agents, Urinary / therapeutic use. Maternal-Fetal Exchange. Nitrofurantoin / therapeutic use. Urinary Tract Infections / drug therapy

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  • [Copyright] © The Author(s) 2013.
  • (PMID = 23873250.001).
  • [ISSN] 1552-4604
  • [Journal-full-title] Journal of clinical pharmacology
  • [ISO-abbreviation] J Clin Pharmacol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
  • [Keywords] NOTNLM ; congenital malformations / nitrofurantoin / pregnancy
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35. Reynolds TD, Thomas J: Nitrofurantoin related pulmonary disease: a clinical reminder. BMJ Case Rep; 2013;2013
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  • [Title] Nitrofurantoin related pulmonary disease: a clinical reminder.
  • It transpired that 4 months prior to the onset of symptoms she had been started on nitrofurantoin for prophylaxis against urinary tract infections.
  • The nitrofurantoin was stopped and she was started on prednisolone.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Lung Diseases / chemically induced. Nitrofurantoin / adverse effects

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  • (PMID = 23729707.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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36. Mendoza-Valdes A, Rosete A, Rios Bueno E, Frentzel A, Trapp S, Kirch W, Mueller EA: [Antimicrobial and clinical efficacy of nitrofurantoin in the treatment of acute lower urinary tract infections in adults]. Med Klin (Munich); 2010 Oct;105(10):698-704
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Antimicrobial and clinical efficacy of nitrofurantoin in the treatment of acute lower urinary tract infections in adults].
  • [Transliterated title] Antimikrobielle und klinische Wirksamkeit von Nitrofurantoin in der Behandlung akuter Infekte der unteren ableitenden Harnwege bei Erwachsenen.
  • BACKGROUND AND PURPOSE: In the light of increasing resistance to antibiotics used for the treatment of acute urinary tract infections, nitrofurantoin currently experiences a renaissance.
  • Nitrofurantoin shows good efficacy against most bacteria expected in urinary tract infection, and the development of resistance is low.
  • A study on the antimicrobial and clinical efficacy of nitrofurantoin in the treatment of acute lower urinary tract infections was conducted in Mexico City, an area where resistance rates of uropathogens to trimethoprim/sulfamethoxazole (cotrimoxazole) are high.
  • PATIENTS AND METHODS: In this open-label, single-arm study 20 adult patients (18 females, 2 males) with positive urine culture were treated orally with nitrofurantoin sustained release 100 mg twice daily for 7 days.
  • Urinary nitrofurantoin concentrations were determined at baseline and day 4 of the study.
  • Primary endpoint was the antimicrobial efficacy of nitrofurantoin at 12 to 16 days after baseline, assessed by changes in urine culture results.
  • Urinary nitrofurantoin concentrations were mostly above minimum inhibitory concentrations of the isolated uropathogens.
  • CONCLUSION: The results of the present study indicate good antimicrobial and clinical efficacy of nitrofurantoin in the treatment of acute uncomplicated urinary tract infections as well as acceptable tolerability in adults.
  • [MeSH-major] Anti-Infective Agents, Urinary / therapeutic use. Bacteriuria / drug therapy. Nitrofurantoin / therapeutic use. Urinary Tract Infections / drug therapy

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  • (PMID = 20981588.001).
  • [ISSN] 1615-6722
  • [Journal-full-title] Medizinische Klinik (Munich, Germany : 1983)
  • [ISO-abbreviation] Med. Klin. (Munich)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 0 / Delayed-Action Preparations; 927AH8112L / Nitrofurantoin
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37. Silva AR, Santos EB, Pinto SC, Gomes JC, Vaz IP, Carvalho MF: Antimicrobial effect and transdentinal diffusion of new intracanal formulations containing nitrofurantoin or doxycycline. Braz Dent J; 2014 Oct;25(5):425-9
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  • [Title] Antimicrobial effect and transdentinal diffusion of new intracanal formulations containing nitrofurantoin or doxycycline.
  • The medications tested were a placebo gel (PC); the new formulations with either 3% nitrofurantoin (NIT) or 3% doxycycline hydrochloride (DX) and 2% chlorhexidine (CHX) gel as positive control.

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  • (PMID = 25517779.001).
  • [ISSN] 1806-4760
  • [Journal-full-title] Brazilian dental journal
  • [ISO-abbreviation] Braz Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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38. Moghimipour E, Salimi A, Rezaee S, Balack M, Handali S: Influence of flocculating agents and structural vehicles on the physical stability and rheological behavior of nitrofurantoin suspension. Jundishapur J Nat Pharm Prod; 2014 May;9(2):e12716
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of flocculating agents and structural vehicles on the physical stability and rheological behavior of nitrofurantoin suspension.
  • BACKGROUND: Nitrofurantoin is a nitrofuran antibiotic that has been used for treatment of urinary tract against positive and negative bacteria.
  • OBJECTIVES: The aim of this study was to evaluate the effect of structural vehicles and flocculating agents on physical stability and rheological behavior of nitrofurantoin suspension.

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  • (PMID = 24872937.001).
  • [ISSN] 1735-7780
  • [Journal-full-title] Jundishapur journal of natural pharmaceutical products
  • [ISO-abbreviation] Jundishapur J Nat Pharm Prod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC4036373
  • [Keywords] NOTNLM ; Nitrofurantoin / Rheology / Suspensions / Wetting Agents
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39. American College of Obstetricians and Gynecologists Committee on Obstetric Practice: ACOG Committee Opinion No. 494: Sulfonamides, nitrofurantoin, and risk of birth defects. Obstet Gynecol; 2011 Jun;117(6):1484-5
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  • [Title] ACOG Committee Opinion No. 494: Sulfonamides, nitrofurantoin, and risk of birth defects.
  • Prescribing sulfonamides or nitrofurantoin in the first trimester is still considered appropriate when no other suitable alternative antibiotics are available.
  • [MeSH-major] Abnormalities, Drug-Induced. Anti-Infective Agents, Urinary / adverse effects. Nitrofurantoin / adverse effects. Sulfonamides / adverse effects

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  • (PMID = 21606771.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 0 / Sulfonamides; 927AH8112L / Nitrofurantoin
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40. Livermore DM, Warner M, Mushtaq S, Doumith M, Zhang J, Woodford N: What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents; 2011 May;37(5):415-9
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  • [Title] What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline.
  • In this study, the activity of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline was evaluated against 81 carbapenem-resistant Enterobacteriaceae isolates from the UK.
  • Chloramphenicol, ciprofloxacin and nitrofurantoin inhibited <25% of the isolates at the breakpoint, whereas colistin was active against 75/81 isolates (92.6%), the exceptions being four Klebsiella pneumoniae and Enterobacter cloacae isolates along with members of inherently resistant genera.


41. Goldberg O, Moretti M, Levy A, Koren G: Exposure to nitrofurantoin during early pregnancy and congenital malformations: a systematic review and meta-analysis. J Obstet Gynaecol Can; 2015 Feb;37(2):150-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Exposure to nitrofurantoin during early pregnancy and congenital malformations: a systematic review and meta-analysis.
  • OBJECTIVE: Because of an increased resistance of urinary pathogens to penicillin derivatives, nitrofurantoin is commonly used as an alternative in treating urinary tract infection because a wide range of both Gram negative and positive organisms are sensitive to it.
  • The safety of the fetus after exposure to nitrofurantoin remains controversial.
  • METHODS: We conducted a systematic review and meta-analysis to evaluate the fetal safety of nitrofurantoin.
  • Articles were included in the review if they were human studies, reported pregnancy outcomes, reported the use of nitrofurantoin in the first trimester of pregnancy, and included a comparator group of unexposed pregnancies.
  • CONCLUSION: While no association was found between fetal exposure to nitrofurantoin and major malformation in cohort studies, there was a slight but significant teratogenic risk in case-control studies, which are more sensitive to adverse effects.
  • [MeSH-major] Abnormalities, Drug-Induced / etiology. Anti-Infective Agents, Urinary / adverse effects. Nitrofurantoin / adverse effects

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  • (PMID = 25767948.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
  • [Keywords] NOTNLM ; congenital malformations / meta-analysis / nitrofurantoin / pregnancy
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42. Štuhec M: Auditory hallucinations associated with nitrofurantoin use: case report and review of the literature. Wien Klin Wochenschr; 2014 Sep;126(17-18):549-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Auditory hallucinations associated with nitrofurantoin use: case report and review of the literature.
  • OBJECTIVE: In this case report, we present an 83-year-old Caucasian immune-competent woman with Alzheimer's disease and organic personality disorder who developed auditory hallucinations when treated with two nitrofurantoin (NF) tablets (100 mg) every 12 h because of acute cystitis due to extended-spectrum-β-lactamase-positive Escherichia coli.

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  • (PMID = 25123143.001).
  • [ISSN] 1613-7671
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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43. Athikomrattanakul U, Gajovic-Eichelmann N, Scheller FW: Thermometric sensing of nitrofurantoin by noncovalently imprinted polymers containing two complementary functional monomers. Anal Chem; 2011 Oct 15;83(20):7704-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Thermometric sensing of nitrofurantoin by noncovalently imprinted polymers containing two complementary functional monomers.
  • Molecularly imprinted polymers (MIPs) for nitrofurantoin (NFT) recognition addressing in parallel of two complementary functional groups were created using a noncovalent imprinting approach.
  • Specific tailor-made functional monomers were synthesized: a diaminopyridine derivative as the receptor for the imide residue and three (thio)urea derivatives for the interaction with the nitro group of NFT.
  • A significantly improved binding of NFT to the new MIPs was revealed from the imprinting factor, efficiency of binding, affinity constants and maximum binding number as compared to previously reported MIPs, which addressed either the imide or the nitro residue.
  • Substances possessing only one functionality (either the imide group or nitro group) showed significantly weaker binding to the new imprinted polymers than NFT.
  • [MeSH-major] Molecular Imprinting. Nitrofurantoin / analysis. Polymers / chemistry. Temperature

  • HSDB. structure - PYRIDINE.
  • HSDB. structure - UREA.
  • HSDB. structure - NITROFURANTOIN.
  • HSDB. structure - DIMETHYL SULFOXIDE.
  • HSDB. structure - ACETONITRILE.
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  • [Copyright] © 2011 American Chemical Society
  • (PMID = 21958006.001).
  • [ISSN] 1520-6882
  • [Journal-full-title] Analytical chemistry
  • [ISO-abbreviation] Anal. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acetonitriles; 0 / Imides; 0 / Polymers; 0 / Pyridines; 8W8T17847W / Urea; 927AH8112L / Nitrofurantoin; NH9L3PP67S / pyridine; YOW8V9698H / Dimethyl Sulfoxide; Z072SB282N / acetonitrile
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44. Poulsen HO, Johansson A, Granholm S, Kahlmeter G, Sundqvist M: High genetic diversity of nitrofurantoin- or mecillinam-resistant Escherichia coli indicates low propensity for clonal spread. J Antimicrob Chemother; 2013 Sep;68(9):1974-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High genetic diversity of nitrofurantoin- or mecillinam-resistant Escherichia coli indicates low propensity for clonal spread.
  • METHODS: In this study we investigated the clonal structure of 34 strains of E. coli (collected from non-pregnant women aged 18-65 years with uncomplicated UTIs in Europe and Canada) resistant to either of two other common treatment alternatives for uncomplicated UTIs, mecillinam or nitrofurantoin, using multilocus sequence typing (MLST).
  • CONCLUSIONS: The results of this study indicate a low probability of a future clonal spread of resistance to mecillinam and nitrofurantoin.
  • [MeSH-major] Amdinocillin / pharmacology. Drug Resistance, Bacterial. Escherichia coli / classification. Escherichia coli / genetics. Escherichia coli Infections / epidemiology. Genetic Variation. Nitrofurantoin / pharmacology

  • MedlinePlus Health Information. consumer health - E. Coli Infections.
  • HSDB. structure - NITROFURANTOIN.
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  • (PMID = 23640126.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 32887-01-7 / Amdinocillin; 927AH8112L / Nitrofurantoin
  • [Keywords] NOTNLM ; antimicrobial resistance / successful clones / uncomplicated urinary tract infections
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45. Hydes T, Wright M, Jaynes E, Nash K: Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication. BMJ Case Rep; 2014;2014
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication.
  • Nitrofurantoin is recommended for first line prophylaxis of recurrent urinary tract infections.
  • Nitrofurantoin-induced immune-mediated liver injury is a particularly serious complication, resulting in both acute hepatic failure and cirrhosis with continued use.
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Drug-Induced Liver Injury / pathology. Hepatitis, Autoimmune / pathology. Liver / pathology. Nitrofurantoin / adverse effects

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  • HSDB. structure - NITROFURANTOIN.
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  • (PMID = 24599428.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Infective Agents, Urinary; 927AH8112L / Nitrofurantoin
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46. Sargın G, Elbek O, Balantekin C, Meteoglu I, Culhacı N: Acute respiratory distress syndrome and hepatotoxicity associated with single dose nitrofurantoin use. Case Rep Pulmonol; 2012;2012:465389
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute respiratory distress syndrome and hepatotoxicity associated with single dose nitrofurantoin use.
  • Nitrofurantoin is a synthetic nitrofuran compound.
  • A number of adverse effects may develop in different body systems during nitrofurantoin treatment; however, concomitant pulmonary and hepatotoxicity are rare.
  • In this paper, we present a case of acute respiratory distress syndrome and hepatotoxicity following administration of a single dose of nitrofurantoin.

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  • (PMID = 23227407.001).
  • [ISSN] 2090-6854
  • [Journal-full-title] Case reports in pulmonology
  • [ISO-abbreviation] Case Rep Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3514810
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47. Geerts AF, Eppenga WL, Heerdink R, Derijks HJ, Wensing MJ, Egberts TC, De Smet PA: Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care. Eur J Clin Pharmacol; 2013 Sep;69(9):1701-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care.
  • PURPOSE: To determine whether treatment with nitrofurantoin in women with urinary tract infection (UTI) and renal impairment in primary care is associated with a higher risk of ineffectiveness and/or serious adverse events than in women without renal impairment.
  • METHODS: A cohort of 21,317 women treated with nitrofurantoin and a cohort of 7,926 women treated with trimethoprim, identified from the Pharmo Record Linkage System, were analysed.
  • The primary outcome was ineffectiveness of treatment of nitrofurantoin defined as the start of a second antibacterial within 1 month after the start of nitrofurantoin.
  • The secondary outcome was the occurrence of serious adverse events of nitrofurantoin leading to hospitalization within 90 days.
  • A cohort of trimethoprim users was used to determine if the associations found for nitrofurantoin were mainly related to nitrofurantoin itself.
  • In patients with renal impairment (<50 ml/min/1.73 m²) the risk of pulmonary adverse events leading to hospitalization was significantly increased (HR 4.1, 95 % CI 1.31-13.09) CONCLUSIONS: Nitrofurantoin treatment was not associated with a higher risk of ineffectiveness in women with UTI and moderate renal impairment (30-50 ml/min/1.73 m²).
  • [MeSH-major] Anti-Infective Agents, Urinary / adverse effects. Nitrofurantoin / adverse effects. Renal Insufficiency / drug therapy. Urinary Tract Infections / drug therapy


48. Sanchez GV, Baird AM, Karlowsky JA, Master RN, Bordon JM: Nitrofurantoin retains antimicrobial activity against multidrug-resistant urinary Escherichia coli from US outpatients. J Antimicrob Chemother; 2014 Dec;69(12):3259-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nitrofurantoin retains antimicrobial activity against multidrug-resistant urinary Escherichia coli from US outpatients.
  • Six antimicrobial agents from six separate drug classes were included: ampicillin, cefalotin, ciprofloxacin, nitrofurantoin, trimethoprim/sulfamethoxazole and amoxicillin/clavulanate.
  • In isolates that demonstrated resistance to three, four or five antimicrobial agents in 2010, resistance to nitrofurantoin was observed in only 2.1%, 7.5% and 24.1% of isolates, respectively.
  • CONCLUSIONS: Because of its consistent antimicrobial activity against MDR E. coli, nitrofurantoin remains a reliable first-line agent for the empirical treatment of acute uncomplicated cystitis.

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  • [Copyright] © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
  • (PMID = 25063776.001).
  • [ISSN] 1460-2091
  • [Journal-full-title] The Journal of antimicrobial chemotherapy
  • [ISO-abbreviation] J. Antimicrob. Chemother.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; antibiotic resistance / ciprofloxacin / community / guidelines / primary care / sulphonamides / urinary tract infections
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49. Sherigar JM, Fazio R, Zuang M, Arsura E: Autoimmune hepatitis induced by nitrofurantoin. The importance of the autoantibodies for an early diagnosis of immune disease. Clin Pract; 2012 Oct 12;2(4):e83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autoimmune hepatitis induced by nitrofurantoin. The importance of the autoantibodies for an early diagnosis of immune disease.
  • Nitrofurantoin has been in use since 1953 as an effective agent for the prevention of recurrent urinary tract infection.
  • We present a case of nitrofurantoin induced chronic active hepatitis and briefly review the serology and clinico pathological features of 57 similar cases reported in English literature.
  • Complete recovery is possible in most cases if medication is discontinued in time.
  • Steroids may play a role in management if no improvement occurs despite discontinuation of medication.
  • We suggest all patients who are on prolonged nitrofurantoin therapy be followed up with anti nuclear antibody, anti smooth muscle antibody, serum immunoglobulin and hepatic panel every three months.

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  • (PMID = 24765482.001).
  • [ISSN] 2039-7275
  • [Journal-full-title] Clinics and practice
  • [ISO-abbreviation] Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3981194
  • [Keywords] NOTNLM ; anti nuclear antibody / anti smooth muscle antibody / chronic active hepatitis / hepatotoxicity. / nitrofurantoin
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50. Appleyard S, Saraswati R, Gorard DA: Autoimmune hepatitis triggered by nitrofurantoin: a case series. J Med Case Rep; 2010;4:311
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Autoimmune hepatitis triggered by nitrofurantoin: a case series.
  • CASE PRESENTATION: Three Caucasian women (aged 65, 42 and 74 years old) who were receiving long-term nitrofurantoin as prophylaxis against recurrent urinary tract infections developed hepatitic liver disease.
  • In all three patients nitrofurantoin was withdrawn, and long-term immunosuppressive therapy with prednisolone and azathioprine or mycophenolate was given.
  • CONCLUSIONS: Although nitrofurantoin rarely causes autoimmune hepatitis, this antimicrobial is increasingly used as long-term prophylaxis against recurrent urinary tract infection.
  • General practitioners and urologists who prescribe long-term nitrofurantoin therapy should be aware of this adverse effect.

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  • (PMID = 20863377.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2955056
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