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1. Biomedical articles (top 50; 2009 to 2014)
1. ||||||.... 57%  Li J, Liu H, Ge LH: [Study on dental pulp stem cells from patients with hypophosphatasia]. Beijing Da Xue Xue Bao; 2009 Feb 18;41(1):66-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Study on dental pulp stem cells from patients with hypophosphatasia].
  • OBJECTIVE: To find out whether the dentin formation of hypophosphatasia children is affected; to study the biological difference of cultured human dental pulp cells from deciduous teeth between hypophosphatasia and normal healthy children.
  • METHODS: Anterior deciduous teeth were collected from hypophosphatasia (experiment group) and normal healthy children (control group) respectively.
  • Grounding sections of the affected and healthy deciduous teeth were made to observe their roots; the dental pulp cells were separated and cultured.
  • The characteristics of cell proliferation, differentiation and calcification were studied and compared between the two groups of children.
  • MTT assay was performed to study the growth curves of the cells; RT-PCR was performed to evaluate the expression of tissue nonspecific alkaline phosphatase (TNSALP) at different stages; von Kosssa staining was used to test formed calcification nodules after 3 weeks of induction.
  • For proliferation activity and the expression of TNSALP, the dental pulp cells from experiment group was obviously lower than control group.
  • The proliferation, TNSALP expression and calcification capability of the dental pulp cells were influenced in hypophosphatasia patients, and this may be related to the tooth calcification defect.
  • [MeSH-major] Alkaline Phosphatase / metabolism. Cell Proliferation. Dental Pulp / pathology. Hypophosphatasia / pathology. Tooth Calcification / physiology
  • [MeSH-minor] Cell Differentiation / physiology. Cells, Cultured. Child. Child, Preschool. Dental Cementum / metabolism. Dentin / metabolism. Female. Humans. Male. Tooth, Deciduous / pathology

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  • (PMID = 19221568.001).
  • [ISSN] 1671-167X
  • [Journal-full-title] Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
  • [ISO-abbreviation] Beijing Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.1.3.1 / Alkaline Phosphatase
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2. |||||..... 53%  Valizadeh S, Eil N, Ehsani S, Bakhshandeh H: Correlation between dental and cervical vertebral maturation in Iranian females. Iran J Radiol; 2012 Dec;10(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between dental and cervical vertebral maturation in Iranian females.
  • BACKGROUND: Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth.
  • OBJECTIVES: The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturation in Iranian females.
  • To determine the dental maturational stage, calcification of the mandibular teeth except for third molars were rated according to the method suggested by Demirjian et al.
  • Correlations between bone maturation and teeth calcification were showed by Spearman's correlation and Kendall's tau-b coefficients.
  • The association between cervical vertebral maturation and tooth calcification was greatest in the lateral incisor (odds ratio (OR) = 11, 95% confidence interval (CI): 6.6-18.3).
  • CONCLUSION: The relationship between calcification of teeth and maturation of cervical bones was significant.
  • Bone maturation can be predicted by using teeth calcification stages, especially in the second molar, first molar and lateral incisor.

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  • (PMID = 23599706.001).
  • [ISSN] 1735-1065
  • [Journal-full-title] Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society
  • [ISO-abbreviation] Iran J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3618898
  • [Keywords] NOTNLM ; Cervical Vertebrae / Radiography, Panoramic / Tooth Calcification
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3. ||||...... 40%  Cooper IF, Siadaty MS: 'Organ or Tissue Functions' associated with 'Calcification Teeth': Top Publications. BioMedLib Review; OrganOrTissue;CalcificationTeeth:706343201. ISSN: 2331-5717. 2014/4/25
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  • [Title] 'Organ or Tissue Functions' associated with 'Calcification Teeth': Top Publications.
  • There are articles published each month which present 'Organ or Tissue Function' for 'calcification teeth'.
  • Cooper IF et al: 'Hormones' associated with 'Calcification Teeth': Top Publications.
  • Stock SR et al: Sea urchin tooth mineralization: calcite present early in the aboral plumula.
  • Alvares K et al: Echinoderm phosphorylated matrix proteins UTMP16 and UTMP19 have different functions in sea urchin tooth mineralization.
  • Oshiro M et al: Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study.
  • Boskey AL et al: Cell culture systems for studies of bone and tooth mineralization.
  • Kuykendall KL et al: Permanent tooth calcification in chimpanzees (Pan troglodytes): patterns and polymorphisms.
  • Kuykendall KL: Dental development in chimpanzees (Pan troglodytes): the timing of tooth calcification stages.
  • Merwin DR et al: Sibling similarities in the tempo of human tooth mineralization.
  • Olze A et al: Forensic age estimation in living subjects: the ethnic factor in wisdom tooth mineralization.
  • Harris EF et al: Tooth mineralization standards for blacks and whites from the middle southern United States.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706343201.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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4. |||....... 35%  Cooper IF, Siadaty MS: 'Organ or Tissue Functions' associated with 'Troglodytes Troglodytes': Top Publications. BioMedLib Review; OrganOrTissue;TroglodytesTroglodytes:705943949. ISSN: 2331-5717. 2014/9/15
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  • There are articles published each month which present 'Organ or Tissue Function' for 'troglodytes troglodytes'.
  • Kuykendall KL et al: Permanent tooth calcification in chimpanzees (Pan troglodytes): patterns and polymorphisms.
  • Kuykendall KL: Dental development in chimpanzees (Pan troglodytes): the timing of tooth calcification stages.
  • Eder G: A longitudinal study of the kidney function of the chimpanzee (Pan troglodytes) in comparison with humans.
  • Oyen OJ: Masticatory function and histogenesis of the middle and upper face in chimpanzees (Pan troglodytes).
  • Boughner JC et al: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705943949.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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5. |||....... 30%  Cooper IF, Siadaty MS: 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Calcification Teeth': Top Publications. BioMedLib Review; BodyPartOrgan;CalcificationTeeth:706368195. ISSN: 2331-5717. 2014/6/26
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  • [Title] 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Calcification Teeth': Top Publications.
  • There are articles published each month which present 'Body Part Organ or Organ Component' for 'calcification teeth'.
  • Bahetwar SK et al: A biochemical and histopathological evaluation of generalized pulp calcification in young permanent teeth.
  • Weinmann JP et al: Experimental Studies in Calcification: III. The Effect of Parathyroid Hormone on the Alveolar Bone and Teeth of the Normal and Rachitic Rat.
  • Schopf PM: [Root calcification and tooth eruption in the mixed dentition. A study in panoramic x-rays].
  • Mappes MS et al: An example of regional variation in the tempos of tooth mineralization and hand-wrist ossification.
  • Gvozdenović-Simović V: [Mandibular tooth calcification].
  • Kaqueler JC et al: [Effect of sodium selenate on the calcification of teeth and jaws of young rats. Studies using tetracycline].
  • Holtgrave EA et al: Tablet fluoridation influences the calcification of primary tooth pulp.
  • Nakamura Y et al: Calcification of degenerating tissues in the periodontal ligament during tooth movement.
  • Lima JE de O et al: [Influence of salivary glands parotid and submandibulary in the eruption, growing and calcification of the incisive and molar teeth of rats (author's transl)].
  • Tsuchiya T et al: [Observation on calcification of necrotic tissue in pressure side of periodontal membrane incident to experimental tooth movement].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706368195.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. |||....... 27%  Foster BL, Nagatomo KJ, Tso HW, Tran AB, Nociti FH Jr, Narisawa S, Yadav MC, McKee MD, Millán JI, Somerman MJ: Tooth root dentin mineralization defects in a mouse model of hypophosphatasia. J Bone Miner Res; 2013 Feb;28(2):271-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.
  • Tissue-nonspecific alkaline phosphatase (TNAP) is expressed in mineralizing tissues and functions to reduce pyrophosphate (PP(i) ), a potent inhibitor of mineralization.
  • Loss of TNAP function causes hypophosphatasia (HPP), a heritable disorder marked by increased PP(i) , resulting in rickets and osteomalacia.
  • Tooth root cementum defects are well described in both HPP patients and in Alpl(-/-) mice, a model for infantile HPP.
  • In Alpl(-/-) mice, dentin mineralization is specifically delayed in the root; however, reports from human HPP patients are variable and inconsistent regarding dentin defects.
  • TNAP was found to be highly expressed by mature odontoblasts, and Alpl(-/-) molar and incisor roots featured defective dentin mineralization, ranging from a mild delay to severely disturbed root dentinogenesis.
  • Lack of mantle dentin mineralization was associated with disordered and dysmorphic odontoblasts having disrupted expression of marker genes osteocalcin and dentin sialophosphoprotein.
  • The formation of, initiation of mineralization within, and rupture of matrix vesicles in Alpl(-/-) dentin matrix was not affected.
  • Osteopontin (OPN), an inhibitor of mineralization that contributes to the skeletal pathology in Alpl(-/-) mice, was present in the generally unmineralized Alpl(-/-) mantle dentin at ruptured mineralizing matrix vesicles, as detected by immunohistochemistry and by immunogold labeling.
  • However, ablating the OPN-encoding Spp1 gene in Alpl(-/-) mice was insufficient to rescue the dentin mineralization defect.
  • Administration of bioengineered mineral-targeting human TNAP (ENB-0040) to Alpl(-/-) mice corrected defective dentin mineralization in the molar roots.
  • These studies reveal that TNAP participates in root dentin formation and confirm that reduction of PP(i) during dentinogenesis is necessary for odontoblast differentiation, dentin matrix secretion, and mineralization.
  • [MeSH-major] Dentin / physiopathology. Hypophosphatasia / physiopathology. Tooth Calcification. Tooth Root / physiopathology

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  • [Copyright] Copyright © 2013 American Society for Bone and Mineral Research.
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  • (PMID = 22991301.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP-97858; United States / NIAMS NIH HHS / AR / R01 AR047908; United States / NIAMS NIH HHS / AR / R01 AR47908; United States / NIDCR NIH HHS / DE / R01 DE012889; United States / NIDCR NIH HHS / DE / R01 DE015109; United States / NIDCR NIH HHS / DE / R01 DE12889; United States / NIDCR NIH HHS / DE / R01DE15109; United States / NIAMS NIH HHS / AR / Z99 AR999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 106441-73-0 / Osteopontin; EC 3.1.3.1 / Alkaline Phosphatase
  • [Other-IDs] NLM/ NIHMS407464; NLM/ PMC3541444
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7. |||||..... 53%  Chen J, Hu H, Guo J, Liu Z, Liu R, Li F, Zou S: Correlation between dental maturity and cervical vertebral maturity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):777-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between dental maturity and cervical vertebral maturity.
  • OBJECTIVE: The aim of this study was to investigate the association between dental and skeletal maturity.
  • Dental maturity was assessed by calcification stages of the mandibular canines, first and second premolars, and second molars, whereas skeletal maturity was estimated by the cervical vertebral maturation (CVM) stages.
  • The Spearman rank-order correlation coefficient was used to measure the association between CVM stage and dental calcification stage of individual teeth.
  • The Spearman rank-order correlation coefficients between dental maturity and cervical vertebral maturity ranged from 0.391 to 0.582 for girls and from 0.464 to 0.496 for boys (P < 0.05).
  • CONCLUSIONS: Tooth calcification stage was significantly correlated with cervical vertebral maturation stage.
  • Therefore, it is practical to consider the relationship between dental and skeletal maturity when planning orthodontic treatment.
  • [MeSH-major] Age Determination by Skeleton. Age Determination by Teeth
  • [MeSH-minor] Adolescent. Bicuspid / growth & development. Cephalometry. Cervical Vertebrae / growth & development. Child. China. Cohort Studies. Cuspid / growth & development. Dental Pulp Cavity / growth & development. Female. Humans. Male. Mandible. Molar / growth & development. Odontogenesis / physiology. Radiography, Dental, Digital. Radiography, Panoramic. Sex Factors. Tooth Apex / growth & development. Tooth Calcification / physiology. Tooth Crown / growth & development. Tooth Root / growth & development

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 21112534.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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8. ||||...... 42%  Acharya AB: Age estimation in Indians using Demirjian's 8-teeth method. J Forensic Sci; 2011 Jan;56(1):124-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age estimation in Indians using Demirjian's 8-teeth method.
  • Demirjian's grading of tooth calcification is widely used to assess age of individuals with developing dentitions.
  • Conventionally, Demirjian's method utilized seven mandibular teeth on the left side.
  • This paper tested the 8-teeth method using 547 Indians (348 females, 199 males) aged 7-25 years.
  • This suggests that Demirjian's 8-teeth method also needs adaptation prior to use in diverse populations.
  • [MeSH-major] Age Determination by Teeth / methods
  • [MeSH-minor] Adolescent. Adult. Case-Control Studies. Child. European Continental Ancestry Group. Female. Forensic Dentistry / methods. Humans. India. Male. Radiography, Dental. Regression Analysis. Young Adult

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  • [Copyright] © 2010 American Academy of Forensic Sciences.
  • (PMID = 20854361.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. ||||...... 42%  Chindasombatjaroen J, Poomsawat S, Kakimoto N, Shimamoto H: Calcifying cystic odontogenic tumor and adenomatoid odontogenic tumor: radiographic evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol; 2012 Dec;114(6):796-803
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Location, border, relationship of the lesion with the impacted tooth, calcification patterns, tooth displacement, and root resorption were evaluated.
  • Three CCOTs and 7 AOTs enclosed impacted teeth.
  • Of these cases, the radiolucencies of 3 CCOTs and 1 AOT were attached to the impacted teeth at the cementoenamel junctions.
  • Three AOTs enclosed more portions of the roots, and the other 3 AOTs enclosed the entire teeth.
  • Calcification in CCOTs appeared as a thin radiopaque line (2 cases) and discrete radiopaque foci (1 case), whereas AOTs had numerous dispersed or clustered radiopaque foci (4 cases).
  • CONCLUSIONS: Radiolucency with numerous radiopaque foci (particularly when the radiolucency surrounds a portion of the root or entire tooth) is suggestive of an AOT rather than a CCOT.

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 23159119.001).
  • [ISSN] 2212-4411
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology and oral radiology
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Adenoameloblastoma
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10. |||....... 33%  Surendran S, Thomas E: Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity. Am J Orthod Dentofacial Orthop; 2014 Jan;145(1):7-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity.
  • INTRODUCTION: The objective of this study was to determine whether dental calcification can be used as a first-level diagnostic tool for assessment of skeletal maturity.
  • Dental maturity was assessed through the calcification stages from panoramic radiographs of the mandibular canine, the first and second premolars, and the second molar.
  • RESULTS: Diagnostic ability was evaluated according to the dental maturation stages for each tooth for identification of the MP3 stages and the growth phases (prepubertal, pubertal, postpubertal) using positive likelihood ratios.
  • Dental maturation stage E of the first premolars and the combination of canine stage F, first premolar stage E, second premolar stage E, and second molar stage D (FEED) gave the highest values for identification of the prepubertal growth phase, and stage H of the second molar had the highest value for identification of the postpubertal growth phase.
  • CONCLUSIONS: Dental maturation assessment is only useful for diagnosis of the prepubertal and postpubertal growth phases.
  • [MeSH-major] Age Determination by Skeleton / methods. Tooth Calcification / physiology
  • [MeSH-minor] Adolescent. Bicuspid / growth & development. Bicuspid / radiography. Child. Cross-Sectional Studies. Cuspid / growth & development. Cuspid / radiography. Dental Pulp / growth & development. Dental Pulp / radiography. Epiphyses / growth & development. Epiphyses / radiography. Female. Finger Phalanges / growth & development. Finger Phalanges / radiography. Growth Plate / growth & development. Growth Plate / radiography. Humans. Likelihood Functions. Male. Mandible / radiography. Molar / growth & development. Molar / radiography. Predictive Value of Tests. Puberty / physiology. Radiographic Image Enhancement / methods. Radiography, Dental, Digital / methods. Radiography, Panoramic / methods. Sensitivity and Specificity. Tooth Apex / growth & development. Tooth Apex / radiography. Tooth Crown / growth & development. Tooth Crown / radiography. Tooth Root / growth & development. Tooth Root / radiography

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  • [Copyright] Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Am J Orthod Dentofacial Orthop. 2014 May;145(5):551-2 [24785914.001]
  • [CommentIn] Am J Orthod Dentofacial Orthop. 2014 May;145(5):552-3 [24785916.001]
  • (PMID = 24373650.001).
  • [ISSN] 1097-6752
  • [Journal-full-title] American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
  • [ISO-abbreviation] Am J Orthod Dentofacial Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. |||....... 26%  McKee MD, Yadav MC, Foster BL, Somerman MJ, Farquharson C, Millán JL: Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization. J Dent Res; 2013 Aug;92(8):721-7
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  • [Title] Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.
  • Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood.
  • Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without TNAP lack acellular cementum, and have mineralization defects in dentin, enamel, and bone.
  • PHOSPHO1 is a phosphatase found within membrane-bounded matrix vesicles in mineralized tissues, and double ablation of Alpl and Phospho1 in mice leads to a complete absence of skeletal mineralization.
  • Here, we describe mineralization abnormalities in the teeth of Phospho1(-/-) mice, and in compound knockout mice lacking Phospho1 and one allele of Alpl (Phospho1(-/-);Alpl(+/-) ).
  • In wild-type mice, PHOSPHO1 and TNAP co-localized to odontoblasts at early stages of dentinogenesis, coincident with the early mineralization of mantle dentin.
  • In Phospho1 knockout mice, radiography, micro-computed tomography, histology, and transmission electron microscopy all demonstrated mineralization abnormalities of incisor dentin, with the most remarkable findings being reduced overall mineralization coincident with decreased matrix vesicle mineralization in the Phospho1(-/-) mice, and the almost complete absence of matrix vesicles in the Phospho1(-/-);Alpl(+/-) mice, whose incisors showed a further reduction in mineralization.
  • Results from this study support prominent non-redundant roles for both PHOSPHO1 and TNAP in dentin mineralization.
  • [MeSH-major] Alkaline Phosphatase / genetics. Dentin / enzymology. Phosphoric Monoester Hydrolases / genetics. Tooth Calcification / genetics
  • [MeSH-minor] Alleles. Alveolar Process / enzymology. Ameloblasts / enzymology. Animals. Apatites / analysis. Calcification, Physiologic / genetics. Dentinogenesis / genetics. Enamel Organ / enzymology. Extracellular Matrix / enzymology. Immunohistochemistry. Incisor / enzymology. Mice. Mice, Inbred C57BL. Mice, Inbred Strains. Mice, Knockout. Mice, Mutant Strains. Microscopy, Electron, Transmission. Molar / enzymology. Odontoblasts / enzymology. Osteoblasts / enzymology. Radiographic Image Enhancement. Tooth Germ / enzymology. X-Ray Microtomography

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  • (PMID = 23694930.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] United Kingdom / Arthritis Research UK / / 20413; United States / NIAMS NIH HHS / AR / AR53102; United States / NIDCR NIH HHS / DE / DE12889; Canada / Canadian Institutes of Health Research / / MOP97858; United States / NIAMS NIH HHS / AR / R01 AR053102; United States / NIDCR NIH HHS / DE / R01 DE012889; United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apatites; EC 3.1.3.- / PHOSPHO1 protein, mouse; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase 2, mouse
  • [Other-IDs] NLM/ PMC3711567
  • [Keywords] NOTNLM ; extracellular matrix / extracellular matrix proteins / matrix vesicles / phosphatase / tissue-non-specific alkaline phosphatase / tooth
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12. |||....... 26%  Burt NM, Sauer N, Fenton T: Testing the Demirjian and the international Demirjian dental aging methods on a mixed ancestry urban American subadult sample from Detroit, MI. J Forensic Sci; 2011 Sep;56(5):1296-301
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  • [Title] Testing the Demirjian and the international Demirjian dental aging methods on a mixed ancestry urban American subadult sample from Detroit, MI.
  • This paper tests the Demirjian and international Demirjian dental aging methods for forensic use when ancestry and ethnicity are unknown.
  • [MeSH-major] Age Determination by Teeth / methods. Continental Population Groups. Tooth Calcification

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  • [Copyright] © 2011 American Academy of Forensic Sciences.
  • (PMID = 21777240.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. |||....... 26%  Galić I, Vodanović M, Janković S, Mihanović F, Nakaš E, Prohić S, Galić E, Brkić H: Dental age estimation on Bosnian-Herzegovinian children aged 6-14 years: evaluation of Chaillet's international maturity standards. J Forensic Leg Med; 2013 Jan;20(1):40-5
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  • [Title] Dental age estimation on Bosnian-Herzegovinian children aged 6-14 years: evaluation of Chaillet's international maturity standards.
  • BACKGROUND: Dental age estimation in children plays an important role in forensic dentistry.
  • It generally overestimates dental age in many populations.
  • OBJECTIVES: The aim of this study was to evaluate the applicability of Chaillet's international scores in the dental age assessment on Bosnian Herzegovinian (BH) children.
  • The dental ages for both genders were compared to the chronological ages through a paired t-test.
  • The absolute accuracy of residuals between the dental and chronological age were 0.65 ± 0.52 years for girls (Median: 0.52 years) and 0.73 ± 0.60 years for boys (Median: 0.57 years).
  • CONCLUSION: The Polynomial compound formula was recommended to predict dental age with more accuracy for results of international maturity standards on BH children.
  • [MeSH-major] Age Determination by Teeth / methods. Tooth Calcification

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  • [Copyright] Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 23217374.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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14. ||........ 25%  Maled V, Manjunatha B, Patil K, Balaraj BM: The chronology of third molar root mineralization in south Indian population. Med Sci Law; 2014 Jan;54(1):28-34
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  • [Title] The chronology of third molar root mineralization in south Indian population.
  • The aim of present study was to determine the chronology of third molar root mineralization and to establish south Indian reference data.
  • Therefore, a cross-sectional study was undertaken by evaluating 192 intraoral periapical radiographs in order to assess the root mineralization status of the mandibular third molar of south Indian individuals (101 males and 91 females) between the age of 13 and 25.
  • The range, mean age, standard deviation, Student t test and percentile distributions are presented for each stage of mineralization.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification. Tooth Root / growth & development

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  • (PMID = 23966355.001).
  • [ISSN] 0025-8024
  • [Journal-full-title] Medicine, science, and the law
  • [ISO-abbreviation] Med Sci Law
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; age estimation / forensic odontology / identification / radiography / root mineralization / south Indian / third molar
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15. ||........ 25%  Lopez TT, Arruda CP, Rocha M, Rosin AS, Michel-Crosato E, Biazevic MG: Estimating ages by third molars: stages of development in Brazilian young adults. J Forensic Leg Med; 2013 Jul;20(5):412-8
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  • Differences were found in the stages of tooth formation between male and female, but differences were not observed between the left and right sides.
  • We found that both DT and MST underestimated the ages in about 6 months, depending on the used classification and number of teeth.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 23756509.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. ||........ 24%  Sahlstrand P, Lith A, Hakeberg M, Norén JG: Timing of mineralization of homologues permanent teeth--an evaluation of the dental maturation in panoramic radiographs. Swed Dent J; 2013;37(3):111-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Timing of mineralization of homologues permanent teeth--an evaluation of the dental maturation in panoramic radiographs.
  • An explanation to these variations could be that the start of the enamel mineralization differs between homologues teeth.
  • The aim of this study was to compare the dental development between homologues teeth in digital panoramic radiographs (PRs),from children aged 7 to 11 years, using the Gleiser & Hunt method on second and third molars and to calculate the crown/root ratio for the mandibular premolars.77 PRs, from individuals between 7.3 and 11.0 years of age, were studied.
  • Differences in developmental stages between homologues teeth (second and third molars) were studied.
  • A possible explanation to the variations in expressivity of MIH may be a result of differences in the start of mineralization between homologues teeth.
  • Timing of mineralization of homologues permanent teeth--An evaluation of the dental maturation in panoramic radiographs.
  • [MeSH-major] Age Determination by Teeth. Dental Enamel Hypoplasia / physiopathology. Tooth Calcification / physiology

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  • (PMID = 24341164.001).
  • [ISSN] 0347-9994
  • [Journal-full-title] Swedish dental journal
  • [ISO-abbreviation] Swed Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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17. ||........ 24%  Karataş OH, Öztürk F, Dedeoğlu N, Çolak C, Altun O: Radiographic evaluation of third-molar development in relation to the chronological age of Turkish children in the southwest Eastern Anatolia region. Forensic Sci Int; 2013 Oct 10;232(1-3):238.e1-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To study the chronological age of third-molar mineralisation of Turkish children from the southwest Eastern Anatolia region, the Demirjian staging method was used to determine the stage of the mineralisation of four third molars (18, 28, 38 and 48) and to compare third-molar development by sex and age with the results of previous studies.
  • Regression analysis was performed to obtain regression formulae for calculating the dental and the chronological age.
  • The results showed that there was no significant difference in mineralisation between 18 and 28 and 38 and 48 in males or females.
  • For both sexes, the dental age was lower than the chronological age.
  • In the whole population, the boys' and the girls' dental ages were 0.84 years and 0.16 years earlier, respectively, than their chronological ages.
  • The use of third-molar teeth as a developmental marker is suitable, particularly when comparing the obtained standard deviation with other skeletal-age calculation techniques.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Molar, Third / radiography. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 24001572.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Keywords] NOTNLM ; Age estimation / Chronological age / Dental age / Dental mineralisation / Third molar
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18. ||........ 24%  Kumar S, Singla A, Sharma R, Virdi MS, Anupam A, Mittal B: Skeletal maturation evaluation using mandibular second molar calcification stages. Angle Orthod; 2012 May;82(3):501-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skeletal maturation evaluation using mandibular second molar calcification stages.
  • OBJECTIVE: To investigate (1) the relationships between the stages of mandibular second molar calcification and skeletal maturity; and (2) whether second molar calcification stages can be used as a reliable diagnostic tool to determine skeletal maturity.
  • MATERIALS AND METHODS: Samples were derived from panoramic radiographs and lateral cephalograms of 300 subjects (137 males and 163 females) with ages ranging from 9 to 18 years, and estimates of dental maturity (Demirjian Index [DI]) and skeletal maturity (cervical vertebrae maturation indicators [CVMI]) were made.
  • [MeSH-major] Age Determination by Teeth. Molar / growth & development. Tooth Calcification / physiology

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  • (PMID = 21899377.001).
  • [ISSN] 1945-7103
  • [Journal-full-title] The Angle orthodontist
  • [ISO-abbreviation] Angle Orthod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. ||........ 24%  Boughner JC, Dean MC, Wilgenbusch CS: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes). Am J Phys Anthropol; 2012 Dec;149(4):560-71
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  • [Title] Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).
  • The timing of tooth mineralization in bonobos (Pan paniscus) is virtually uncharacterized.
  • Analysis of these developmental features in bonobos and the possible differences with its sister species, the chimpanzee (P. troglodytes), is important to properly quantify the normal ranges of dental growth variation in closely related primate species.
  • Understanding this variation among bonobo, chimpanzee and modern human dental development is necessary to better contextualize the life histories of extinct hominins.
  • This study tests whether bonobos and chimpanzees are distinguished from each other by covariance among the relative timing and sequences of tooth crown initiation, mineralization, root extension, and completion.
  • Using multivariate statistical analyses, we compared the relative timing of permanent tooth crypt formation, crown mineralization, and root extension between 34 P. paniscus and 80 P. troglodytes mandibles radiographed in lateral and occlusal views.
  • Covariance among our 12 assigned dental scores failed to statistically distinguish between bonobos and chimpanzees.
  • Dental scores covaried similarly between the incisors, as well as between both premolars.
  • Conversely, covariance among dental scores distinguished the canine and each of the three molars not only from each other, but also from the rest of the anterior teeth.
  • Our study showed no significant differences in the relative timing of permanent tooth crown and root formation between bonobos and chimpanzees.
  • [MeSH-major] Pan paniscus / growth & development. Pan troglodytes / growth & development. Tooth Calcification / physiology
  • [MeSH-minor] Age Factors. Animals. Cluster Analysis. Cuspid / anatomy & histology. Cuspid / metabolism. Female. Male. Molar / anatomy & histology. Molar / metabolism. Multivariate Analysis. Principal Component Analysis. Tooth Crown / anatomy & histology. Tooth Crown / metabolism. Tooth Root / anatomy & histology. Tooth Root / metabolism

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 23097136.001).
  • [ISSN] 1096-8644
  • [Journal-full-title] American journal of physical anthropology
  • [ISO-abbreviation] Am. J. Phys. Anthropol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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20. ||........ 22%  Lacruz RS, Smith CE, Bringas P Jr, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML: Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol; 2012 May;227(5):2264-75
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  • [Title] Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling.
  • Dental enamel, the most highly mineralized tissue in mammals, differs from other calcifying systems in that the formative cells (ameloblasts) lack remodeling activity and largely degrade and resorb the initial extracellular matrix.
  • Enamel mineralization requires that ameloblasts undergo a profound functional switch from matrix-secreting to maturational (calcium transport, protein resorption) roles as mineralization progresses.
  • To identify the genetic events driving enamel mineralization, we conducted genome-wide transcript profiling of the developing enamel organ from rat incisors and highlight over 300 genes differentially expressed during maturation.
  • Using multiple bioinformatics analyses, we identified groups of maturation-associated genes whose functions are linked to key mineralization processes including pH regulation, calcium handling, and matrix turnover.
  • Subsequent qPCR and Western blot analyses revealed that a number of solute carrier (SLC) gene family members were up-regulated during maturation, including the novel protein Slc24a4 involved in calcium handling as well as other proteins of similar function (Stim1).
  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / chemistry. Dental Enamel / metabolism. Gene Expression Profiling / methods. Genome. Tooth Calcification / genetics

  • HSDB. structure - CALCIUM, ELEMENTAL.
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  • [Copyright] Copyright © 2011 Wiley Periodicals, Inc.
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  • (PMID = 21809343.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE006988; United States / NIDCR NIH HHS / DE / DE013045; United States / NIDCR NIH HHS / DE / DE013404; United States / NIDCR NIH HHS / DE / DE019629; United States / NIDDK NIH HHS / DK / DK058563; United States / NIDDK NIH HHS / DK / DK077162; United States / NIGMS NIH HHS / GM / GM072447; United States / NIDCR NIH HHS / DE / R01 DE006988-26; United States / NIDCR NIH HHS / DE / R01 DE013045; United States / NIDCR NIH HHS / DE / R01 DE013045-13; United States / NIDCR NIH HHS / DE / R01 DE013404; United States / NIDCR NIH HHS / DE / R01 DE013404-05; United States / NIDCR NIH HHS / DE / R01 DE019629; United States / NIDCR NIH HHS / DE / R01 DE019629-01; United States / NIDCR NIH HHS / DE / R01 DE019629-02; United States / NIDCR NIH HHS / DE / R01 DE019629-04; United States / NIDDK NIH HHS / DK / R01 DK058563-10; United States / NIDDK NIH HHS / DK / R01 DK077162-05; United States / NIGMS NIH HHS / GM / R01 GM072477; United States / NIGMS NIH HHS / GM / R01 GM072477-05; United States / NIDCR NIH HHS / DE / R37 DE013045-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS314583; NLM/ PMC3243804
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21. ||........ 22%  Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML: Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci; 2011 Dec;119 Suppl 1:149-57
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  • These results indicate that ameloblasts undergo widespread molecular changes during the maturation stage of amelogenesis and hence provide a basis for future functional investigations into the mechanistic basis of enamel mineralization.
  • [MeSH-major] Ameloblasts / cytology. Amelogenesis / physiology. Enamel Organ / physiology. Gene Expression Profiling. Gene Expression Regulation, Developmental / genetics. Tooth Calcification / genetics

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  • [Copyright] © 2011 Eur J Oral Sci.
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  • (PMID = 22243241.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE013404; United States / NIDCR NIH HHS / DE / DE019629; United States / NIGMS NIH HHS / GM / GM072447; United States / NIDCR NIH HHS / DE / R01 DE013404; United States / NIDCR NIH HHS / DE / R01 DE013404-09; United States / NIDCR NIH HHS / DE / R01 DE019629; United States / NIDCR NIH HHS / DE / R01 DE019629-03; United States / NIGMS NIH HHS / GM / R01 GM072477; United States / NIGMS NIH HHS / GM / R01 GM072477-05S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Other-IDs] NLM/ NIHMS323965; NLM/ PMC3286129
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22. ||........ 22%  Wuscovi LF, Aragón HN, Gordillo ME, López ME: Influence of nutritional state on radiographic variables in upper canine teeth. Acta Odontol Latinoam; 2009;22(1):33-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of nutritional state on radiographic variables in upper canine teeth.
  • Permanent upper canine tooth impaction is related to both genetic causes and nutritional and local causes.
  • Based on radiographic studies of children, Haavikko, 1974, calculated the median of the degree of calcification for each tooth according to age.
  • The aim of our study was to establish associations between certain radiographic variables with respect to upper canine tooth buds and nutritional state in a population of schoolchildren.
  • The program Image tool for Windows was used to measure: (a) distance from the canine cusp to the intermaxillary suture, (b) outer angle formed between the aris of the canine tooth and the plane that cuts the intermaxillary suture perpendicularly, (c) degree of calcification (d) presence of supernumerary teeth.
  • (c) For the ratio between chronological age and dental age calculated according to degree of calcification, significant differences were found between the malnourished and overweight groups (p < 0.01), while the control group showed no difference regarding Haavikko's values (p > 0.05).
  • Both the distance of the canine tooth bud and its degree of calcification vary in patients with nutritional disorders, therefore it would be useful to conduct a radiographic study at school age to detect tooth anomalies and reduce their consequences.
  • [MeSH-major] Cuspid / radiography. Nutritional Status. Tooth Calcification. Tooth Germ / radiography. Tooth, Impacted / radiography

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  • (PMID = 19601494.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Argentina
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23. ||........ 22%  Prabhu RV, Satoskar S, Dinkar AD, Prabhu VD: Dental age estimation among female commercial sex workers in Goa. J Forensic Leg Med; 2013 Aug;20(6):788-91
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  • [Title] Dental age estimation among female commercial sex workers in Goa.
  • AIM: To assess the dental and the skeletal age of rescued female CSWs with an intention of rehabilitation of the minors.
  • METHODOLOGY: Dental age assessment of 32 rescued female CSWs with unknown age was done based on the radiographic analysis using regression equations derived in a Qualitative and Quantitative study by Dinkar A D.
  • When the dental and skeletal age was compared the maximum variation ranged between ± 12 months (1 year).
  • CONCLUSION: Dental age assessment using qualitative and quantitative method given by Dinkar A D can be thought of a reliable method for dental age assessment as it didn't show much variation when compared to the skeletal age of the 32 CSWs.
  • [MeSH-major] Age Determination by Teeth / methods. Sex Workers. Tooth / radiography. Tooth Calcification
  • [MeSH-minor] Adolescent. Age Determination by Skeleton / methods. Bone and Bones / radiography. Child. Female. Forensic Dentistry. Humans. India. Osteogenesis. Radiography, Panoramic. Regression Analysis. Tooth Apex / radiography. Young Adult

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  • [Copyright] Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 23910882.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Dental age / Female CSW / Minor / Skeletal age
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24. ||........ 22%  Singhrao SK, Sloan AJ, Smith EL, Archer CW: Technical advances in the sectioning of dental tissue and of on-section cross-linked collagen detection in mineralized teeth. Microsc Res Tech; 2010 Aug;73(8):741-5
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  • [Title] Technical advances in the sectioning of dental tissue and of on-section cross-linked collagen detection in mineralized teeth.
  • Mineralized teeth are impossible to section when embedded in conventional media, thus limiting on-section characterization of matrix proteins by immunohistochemistry.
  • We hypothesized that by using an especially formulated acrylic resin suitable for mineralized dental tissues, not only sectioning of teeth would be possible, but also our recently developed immunofluorescence labeling technique would be amenable to fully calcified tissues for characterization of dentinal fibrillar collagens, which remains elusive.
  • The hypothesis was tested on fixed rodent teeth embedded in Technovit 9100 New.
  • It was possible to cut thin (1 mum) sections of mineralized teeth, and immunofluorescence characterization of cross-linked type I fibrillar collagen was selected due to its abundance in dentine.
  • Decalcified samples of teeth embedded in paraffin wax were also used to compare immunolabeling from either method using the same immunoreagents in equivalent concentrations.
  • This report offers advances in sectioning mineralized dental tissues and allows the application of immunofluorescence not only for on-section protein detection but importantly for detecting cross-linked fibrous collagens in both soft and mineralized tissue sections.
  • [MeSH-major] Histocytological Preparation Techniques / methods. Tooth / ultrastructure. Tooth Calcification

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  • (PMID = 19953665.001).
  • [ISSN] 1097-0029
  • [Journal-full-title] Microscopy research and technique
  • [ISO-abbreviation] Microsc. Res. Tech.
  • [Language] eng
  • [Grant] United Kingdom / National Centre for the Replacement, Refinement and Reduction of Animals in Research / / G0600349/1
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Acrylic Resins; 0 / Collagen Type I; 0 / Fixatives
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25. ||........ 21%  Khavandgar Z, Alebrahim S, Eimar H, Tamimi F, McKee MD, Murshed M: Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3. J Dent Res; 2013 Apr;92(4):358-64
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  • [Title] Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.
  • A recessive mutation called fragilitas ossium (fro) in the Smpd3 gene leads to impaired mineralization of bone and tooth extracellular matrix (ECM) in fro/fro mice.
  • In teeth from fro/fro mice at various neonatal ages, radiography and light and electron microscopy showed delayed mantle dentin mineralization and a consequent delay in enamel formation as compared with that in control +/fro mice.
  • These tooth abnormalities progressively improved with time.
  • Using a transgenic mouse rescue model (fro/fro; Col1a1-Smpd3) in which Smpd3 expression is driven by a murine Col1a1 promoter fragment active in osteoblasts and odontoblasts, we demonstrate a complete correction of the tooth mineralization delays.
  • In conclusion, analysis of these data demonstrates that Smpd3 expression in odontoblasts is required for tooth mineralization.
  • [MeSH-major] Dental Enamel / enzymology. Osteogenesis Imperfecta / enzymology. Sphingomyelin Phosphodiesterase / metabolism. Tooth Calcification / physiology

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  • (PMID = 23428435.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 123310
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.4.12 / Smpd3 protein, mouse; EC 3.1.4.12 / Sphingomyelin Phosphodiesterase
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26. ||........ 21%  Cantekin K, Sekerci AE, Buyuk SK: Dental computed tomographic imaging as age estimation: morphological analysis of the third molar of a group of Turkish population. Am J Forensic Med Pathol; 2013 Dec;34(4):357-62
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  • [Title] Dental computed tomographic imaging as age estimation: morphological analysis of the third molar of a group of Turkish population.
  • All data were obtained from the patients' records including medical, social, and dental anamnesis and cone-beam CT images of 752 patients.
  • Linear regression analysis was performed to obtain regression formulas for dental age calculation with chronological age and to determine the coefficient of determination (r) for each sex.
  • Computed tomographic images are clinically useful for accurate and reliable estimation of dental ages of children and youth.
  • [MeSH-major] Age Determination by Teeth / methods. Cone-Beam Computed Tomography. Molar, Third / growth & development. Molar, Third / radiography. Tooth Calcification

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 24189628.001).
  • [ISSN] 1533-404X
  • [Journal-full-title] The American journal of forensic medicine and pathology
  • [ISO-abbreviation] Am J Forensic Med Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. ||........ 21%  Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng JQ, Qin C: Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci; 2013 Apr;121(2):76-85
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  • This study focuses on the function of the NH2 -terminal fragment of DSPP in dentinogenesis.
  • The fact that Dspp KO/DSP Tg mice exhibited more severe dentin defects than did the Dspp null mice indicates that the NH2 -terminal fragment of DSPP may inhibit dentin mineralization or may serve as an antagonist against the accelerating action of DPP and serve to prevent predentin from being mineralized too rapidly during dentinogenesis.
  • [MeSH-major] Dentin / metabolism. Dentinogenesis / physiology. Extracellular Matrix Proteins / metabolism. Phosphoproteins / metabolism. Sialoglycoproteins / metabolism. Tooth Calcification / physiology

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  • [Copyright] © 2013 Eur J Oral Sci.
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  • (PMID = 23489896.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE005092; United States / NIDCR NIH HHS / DE / DE015209; United States / NIDCR NIH HHS / DE / R01 DE005092
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein
  • [Other-IDs] NLM/ NIHMS426900; NLM/ PMC3602929
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28. ||........ 21%  Shaw JA, Macey DJ, Brooker LR, Stockdale EJ, Saunders M, Clode PL: Ultrastructure of the epithelial cells associated with tooth biomineralization in the chiton Acanthopleura hirtosa. Microsc Microanal; 2009 Apr;15(2):154-65
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  • [Title] Ultrastructure of the epithelial cells associated with tooth biomineralization in the chiton Acanthopleura hirtosa.
  • The cusp epithelium is a specialized branch of the superior epithelium that surrounds the developing teeth of chitons and is responsible for delivering the elements required for the formation of biominerals within the major lateral teeth.
  • These biominerals are deposited within specific regions of the tooth in sequence, making it possible to conduct a row by row examination of cell development in the cusp epithelium as the teeth progress from the unmineralized to the mineralized state.
  • The onset of iron mineralization within the teeth, initiated at row 13, is associated with a number of dramatic changes in the ultrastructure of the apical cusp cell epithelium.
  • Specifically, the presence of ferritin containing siderosomes, the position and number of mitochondria, and the structure of the cell microvilli are each linked to aspects of the mineralization process.
  • These changes in tissue development are discussed in context with their influence over the physiological conditions within both the cells and extracellular compartment of the tooth at the onset of iron mineralization.
  • [MeSH-major] Epithelial Cells / ultrastructure. Polyplacophora / growth & development. Polyplacophora / ultrastructure. Tooth / growth & development. Tooth Calcification

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  • (PMID = 19284897.001).
  • [ISSN] 1435-8115
  • [Journal-full-title] Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
  • [ISO-abbreviation] Microsc. Microanal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] E1UOL152H7 / Iron
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29. ||........ 21%  Olze A, Pynn BR, Kraul V, Schulz R, Heinecke A, Pfeiffer H, Schmeling A: Studies on the chronology of third molar mineralization in First Nations people of Canada. Int J Legal Med; 2010 Sep;124(5):433-7
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  • [Title] Studies on the chronology of third molar mineralization in First Nations people of Canada.
  • One main criterion for dental age estimation in the relevant age group is the evaluation of third molar mineralization.
  • In the present study, we determined the stages of third molar mineralization in 347 female and 258 male First Nations people of Canada aged 11 to 29 years based on radiological evidence from 605 conventional orthopantomograms.
  • The results presented here provide useful data on the mineralization stages of third molars that can be used for forensic estimation of the minimum and most probable ages including the range of scatter of investigated persons.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / radiography. Tooth Calcification

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  • (PMID = 20623297.001).
  • [ISSN] 1437-1596
  • [Journal-full-title] International journal of legal medicine
  • [ISO-abbreviation] Int. J. Legal Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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30. ||........ 21%  Legović M, Sasso A, Legović I, Brumini G, Cabov T, Slaj M, Vancura I, Lapter M: The reliability of chronological age determination by means of mandibular third molar development in subjects in Croatia. J Forensic Sci; 2010 Jan;55(1):14-8
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  • The frequencies of different stages of mineralization and the mean value of the mineralization of the mandibular third molars with regard to age, gender, and size of the mandible were determined and the coefficient of correlation determined between the age of the subject and the stage of development of the mandibular molars.
  • Statistically significant correlation was determined between mineralization of the mandibular third molar and chronological age of the subjects (boys, mandibular left third molar r = 0.779, right third molar r = 0.793; girls, mandibular left third molar r = 0.746, right third molar r = 0.725).
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • (PMID = 20002266.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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31. ||........ 21%  Kirsch T: Biomineralization--an active or passive process? Connect Tissue Res; 2012;53(6):438-45
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  • Physiological mineralization is restricted to tissues, such as bones, teeth, and certain areas of cartilage.
  • Pathological or ectopic mineralization can occur in many soft tissues, including articular cartilage, cardiovascular tissues, kidney, ligaments, and tendons, and can lead to serious problems.
  • Therefore, the understanding of factors and mechanisms that regulate the mineralization process is essential for the development of novel therapeutic strategies to prevent or inhibit ectopic mineralization.
  • This review will discuss some of the mechanisms and factors that regulate physiological mineralization and their potential roles in ectopic mineralization.
  • Finally, potential therapeutic approaches for the treatment of ectopic mineralization are being discussed.
  • [MeSH-major] Calcification, Physiologic. Calcinosis / metabolism. Tooth Calcification

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  • [CommentIn] Connect Tissue Res. 2012;53(6):437 [23145942.001]
  • (PMID = 22992051.001).
  • [ISSN] 1607-8438
  • [Journal-full-title] Connective tissue research
  • [ISO-abbreviation] Connect. Tissue Res.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / R01AR046245; United States / NIAMS NIH HHS / AR / R01AR049074
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
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32. ||........ 21%  de Oliveira FT, Capelozza AL, Lauris JR, de Bullen IR: Mineralization of mandibular third molars can estimate chronological age--Brazilian indices. Forensic Sci Int; 2012 Jun 10;219(1-3):147-50
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  • [Title] Mineralization of mandibular third molars can estimate chronological age--Brazilian indices.
  • The aim of this study was to determine if the chronology of third molar mineralization could be an accurate indicator of estimated age in a sample Brazilian population.
  • If so, mineralization could determine the probability of an individual being 18 years or older.
  • The study evaluated 407 panoramic radiographs of males and females from the past 5 years in order to assess the mineralization status of the mandibular third molars.
  • The results indicated a strong correlation between chronological age and the mineralization of the mandibular third molars.
  • The results indicated that modern Brazilian generation tends to demonstrate an earlier mandibular third molar mineralization than older Brazilian generation and people of other nationalities.
  • The probability that an individual with third molar mineralization stage H had reached an age of 18 years or older was 96.8-98.6% for males and females, respectively.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 22257966.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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33. ||........ 21%  Bagherpour A, Anbiaee N, Partovi P, Golestani S, Afzalinasab S: Dental age assessment of young Iranian adults using third molars: A multivariate regression study. J Forensic Leg Med; 2012 Oct;19(7):407-12
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  • [Title] Dental age assessment of young Iranian adults using third molars: A multivariate regression study.
  • Radiologic assessment of the mineralisation stage of third molars is of particular importance, with regard to the relevant age group.
  • To attain a referral database and regression equations for dental age estimation of unaccompanied minors in an Iranian population was the goal of this study.
  • With Spearman correlation coefficient, correlation between the scores of all four wisdom teeth, was evaluated.
  • Taking into consideration gender, location and number of wisdom teeth, regression formulae were arrived at.
  • CONCLUSION: Use of population-specific standards is recommended as a means of improving the accuracy of forensic age estimates based on third molars mineralisation.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 22920764.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. ||........ 21%  Li G, Ren J, Zhao S, Liu Y, Li N, Wu W, Yuan S, Wang H: Dental age estimation from the developmental stage of the third molars in western Chinese population. Forensic Sci Int; 2012 Jun 10;219(1-3):158-64
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  • [Title] Dental age estimation from the developmental stage of the third molars in western Chinese population.
  • The purpose of this study is to provide reference data about estimating dental age from third molars of the western Chinese population for comparing with other populations and being applied to the age estimation of western Chinese juveniles and adolescents.
  • The mineralization status of the third molars was assessed using the formation stages described by Demirjian et al. with two modifications.
  • This study provided reference data for the age estimation of western Chinese juveniles and adolescents by the mineralization stages of the third molar.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 22265462.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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35. ||........ 21%  Zeng DL, Wu ZL, Cui MY: Chronological age estimation of third molar mineralization of Han in southern China. Int J Legal Med; 2010 Mar;124(2):119-23
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  • [Title] Chronological age estimation of third molar mineralization of Han in southern China.
  • In order to study the chronology of age of third molar mineralization of Han in southern China, Demirjian staging method was used to determine the stage of four third molars (18, 28, 38, 48) mineralization in 3,100 Han in southern China aged 4.1-26.9 years based on radiological evidence from digital orthopantomograms.
  • Results show that there was no significant difference in mineralization between 18 and 28 and 38 and 48 of male or female.
  • At stages B, E, F, G, and H, the mineralization mean age of male 18 was 0.54, 0.50, 0.76, 0.92, and 0.58 years earlier than that of female, respectively.
  • At stages E, F, G, and H, the mineralization mean age of male 28 was 0.51, 0.76, 0.92, and 0.49 years earlier than that of female, respectively.
  • After reviewing the literature, the chronological mineralization age of 48, at stages D to G, of Han in southern China was 1 to 4.6 years earlier than that of Japanese and 1 to 3 years earlier than that of German.
  • (1) in the same gender group of Han in southern China, the mineralization ages between two sides in upper or lower jaw are very similar, and (2) the chronology mean age and complete time of third molar mineralization of male were earlier than that of female.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. China. Ethnic Groups. Female. Forensic Dentistry. Humans. Male. Radiography, Dental, Digital. Radiography, Panoramic. Sex Characteristics. Young Adult

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  • (PMID = 19908057.001).
  • [ISSN] 1437-1596
  • [Journal-full-title] International journal of legal medicine
  • [ISO-abbreviation] Int. J. Legal Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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36. ||........ 21%  Cantekin K, Yilmaz Y, Demirci T, Celikoglu M: Morphologic analysis of third-molar mineralization for eastern Turkish children and youth. J Forensic Sci; 2012 Mar;57(2):531-4
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  • [Title] Morphologic analysis of third-molar mineralization for eastern Turkish children and youth.
  • To date, there has been no chronological age estimation according to third-molar mineralization in eastern Turkish children and adolescents.
  • Regression analysis was performed to obtain regression formulae for dental age calculation with chronological age.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / radiography. Tooth Calcification

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  • [Copyright] © 2011 American Academy of Forensic Sciences.
  • (PMID = 22211957.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. ||........ 21%  Fang PA, Lam RS, Beniash E: Relationships between dentin and enamel mineral at the dentino-enamel boundary: electron tomography and high-resolution transmission electron microscopy study. Eur J Oral Sci; 2011 Dec;119 Suppl 1:120-4
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  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / metabolism. Dentin / metabolism. Tooth Calcification / physiology

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  • [Copyright] © 2011 Eur J Oral Sci.
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  • (PMID = 22243237.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE016703-06; United States / NIDCR NIH HHS / DE / R01-DE016703
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
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38. ||........ 21%  Kalyva M, Papadimitriou S, Tziafas D: Transdentinal stimulation of tertiary dentine formation and intratubular mineralization by growth factors. Int Endod J; 2010 May;43(5):382-92
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  • [Title] Transdentinal stimulation of tertiary dentine formation and intratubular mineralization by growth factors.
  • AIM: To evaluate the effects of recombinant growth factors on tertiary dentine formation and intratubular mineralization after their application on deep dentinal cavities in dog's teeth.
  • The dentinal responses regarding tertiary dentine formation and intratubular mineralization were assessed after 3 and 8 weeks, respectively, using light and scanning electron microscopy.
  • RESULTS: The group treated with transforming growth factor-beta1 (TGF-beta1) and, to a lesser extent, the one treated with osteogenic protein-1 (OP-1) showed significantly greater (P < 0.05) tertiary dentine formation and intratubular mineralization over an 8-week period when compared with the control and the other experimental groups.
  • CONCLUSION: Treatment of exposed dentinal tubules with biologically active molecules might induce intratubular mineralization and tertiary dentine formation.
  • [MeSH-major] Dentin, Secondary / drug effects. Intercellular Signaling Peptides and Proteins / pharmacology. Tooth Calcification / drug effects
  • [MeSH-minor] Acid Etching, Dental. Animals. Antibodies, Monoclonal / diagnostic use. Bone Morphogenetic Protein 7 / pharmacology. Dental Cavity Preparation / methods. Dentin Permeability / drug effects. Dogs. Fibroblast Growth Factor 2 / pharmacology. Humans. Insulin-Like Growth Factor I / pharmacology. Male. Microscopy, Electron, Scanning. Phosphoric Acids / chemistry. Recombinant Proteins. Time Factors. Transforming Growth Factor beta1 / immunology. Transforming Growth Factor beta1 / pharmacology

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  • (PMID = 20518931.001).
  • [ISSN] 1365-2591
  • [Journal-full-title] International endodontic journal
  • [ISO-abbreviation] Int Endod J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Bone Morphogenetic Protein 7; 0 / Intercellular Signaling Peptides and Proteins; 0 / Phosphoric Acids; 0 / Recombinant Proteins; 0 / Transforming Growth Factor beta1; 103107-01-3 / Fibroblast Growth Factor 2; 67763-96-6 / Insulin-Like Growth Factor I; E4GA8884NN / phosphoric acid
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39. ||........ 21%  Zou W, Hunter N, Swain MV: Application of polychromatic µCT for mineral density determination. J Dent Res; 2011 Jan;90(1):18-30
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  • Accurate assessment of mineral density (MD) provides information critical to the understanding of mineralization processes of calcified tissues, including bones and teeth.
  • High-resolution three-dimensional assessment of the MD of teeth has been demonstrated by relatively inaccessible synchrotron radiation microcomputed tomography (SRµCT).
  • [MeSH-major] Tooth Calcification / physiology. X-Ray Microtomography / methods

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  • (PMID = 20858779.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE015272
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Phosphates; 0 / Polymers; 0 / Potassium Compounds; 16068-46-5 / potassium phosphate; 91D9GV0Z28 / Durapatite
  • [Other-IDs] NLM/ PMC3144098
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40. ||........ 20%  de Moraes ME, de Moraes LC, Cardoso M, Ursi W, Lopes SL: Age assessment based on dental calcification in individuals with Down syndrome. Res Dev Disabil; 2013 Nov;34(11):4274-9
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  • [Title] Age assessment based on dental calcification in individuals with Down syndrome.
  • Use of dental age (DA) for these purposes has been widely studied; however, the literature is scarce with regard to individuals with Down syndrome (DS), a prevalent condition worldwide.
  • In this study the chronology of dental maturation was evaluated by analyzing the DA of individuals with DS based on the Chronological Mineralization Table proposed by Nolla (1960).
  • We concluded that dental maturation in individuals with DS occurs similarly to that of nonsyndromic individuals.
  • [MeSH-major] Age Determination by Teeth / methods. Down Syndrome / radiography. Molar / radiography. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 24095855.001).
  • [ISSN] 1873-3379
  • [Journal-full-title] Research in developmental disabilities
  • [ISO-abbreviation] Res Dev Disabil
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Chronological age / Dental age / Dental maturity / Down syndrome
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41. ||........ 19%  Sheng ZF, Ye W, Wang J, Li CH, Liu JH, Liang QC, Li S, Xu K, Liao EY: OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin. Arch Oral Biol; 2010 Apr;55(4):288-93
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  • [Title] OPG knockout mouse teeth display reduced alveolar bone mass and hypermineralization in enamel and dentin.
  • Recent studies showed that local injection or upregulation of OPG gene would result in early temporal retardation of tooth development.
  • It was assumed that this retardation might cause defective tooth mineralization and pulp formation as the long-term effects.
  • In the present study, a high-resolution microCT was used to evaluate the long-term effect of OPG gene deprivation on the mineralization and morphology of mouse tooth.
  • Our results showed that the mineralization of alveolar bone in OPG(-/-) mouse tooth was decreased while those of enamel and dentin were increased, compared with the wild-type (WT) group.
  • Different responses in mineralization and morphogenesis to OPG gene deprivation were found between bone and tooth.
  • These effects may be independent of the early odontogenesis, and further studies are warranted to investigate the molecular mechanism of the effect of OPG gene expression on bone formation and later tooth development.
  • [MeSH-major] Alveolar Bone Loss / metabolism. Dental Enamel / metabolism. Dentin / metabolism. Dentin Dysplasia / metabolism. Tooth Calcification / genetics

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  • (PMID = 20233613.001).
  • [ISSN] 1879-1506
  • [Journal-full-title] Archives of oral biology
  • [ISO-abbreviation] Arch. Oral Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Osteoprotegerin
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42. ||........ 19%  Perinetti G, Contardo L, Gabrieli P, Baccetti T, Di Lenarda R: Diagnostic performance of dental maturity for identification of skeletal maturation phase. Eur J Orthod; 2012 Aug;34(4):487-92
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  • [Title] Diagnostic performance of dental maturity for identification of skeletal maturation phase.
  • The objective of this study is to analyse the diagnostic performance of the circumpubertal dental maturation phases for the identification of individual-specific skeletal maturation phases.
  • Dental maturity was assessed through the calcification stages from panoramic radiographs of the mandibular canine, the first and second premolars, and the second molar.
  • Diagnostic performances were evaluated according to the dental maturation stages for each tooth for the identification of the CVM stages and growth phases (as pre-pubertal, pubertal, and post-pubertal) using positive likelihood ratios (LHRs).
  • A positive LHR threshold of 10 or more was considered for satisfactory reliability of any dental maturation stage for the identification of any of the CVM stages or growth phases.
  • These four teeth showed positive LHRs greater than 10 only for the identification of the pre-pubertal growth phase, with values from 10.8 for the second molar (stage E) to 39.3 for the first premolar (stage E).
  • Dental maturation assessment is only useful for diagnosis of the pre-pubertal growth phase, and thus, precise information in relation to the timing of the onset of the growth spurt is not provided by these indices.
  • [MeSH-major] Bone Development / physiology. Cervical Vertebrae / growth & development. Puberty / physiology. Tooth Calcification / physiology
  • [MeSH-minor] Adolescent. Age Determination by Skeleton. Age Determination by Teeth. Cephalometry / methods. Child. Female. Humans. Likelihood Functions. Male. Radiography, Panoramic. Reproducibility of Results. Tooth / radiography


43. ||........ 19%  Zhang X, Beck P, Rahemtulla F, Thomas HF: Regulation of enamel and dentin mineralization by vitamin D receptor. Front Oral Biol; 2009;13:102-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Regulation of enamel and dentin mineralization by vitamin D receptor.
  • BACKGROUND: Vitamin D plays an important role in bone mineralization.
  • Enamel and dentin are two mineralized tissues of different origins that are part of the tooth structure, but the mechanism by which vitamin D regulates the mineralization of these tissues remains unclear.
  • We examined the mineral deposition pattern of enamel and dentin in continuously erupting incisors in a vitamin D receptor (VDR) deficient mouse model to determine the effect of vitamin D receptor pathway on enamel and dentin mineralization.
  • Furthermore, an accelerated eruption procedure was performed to exclude the effect of delayed eruption on enamel and dentin mineralization.
  • Early enamel maturation and mineralization, and dentin hypomineralization were observed in the VDR--/-- group.
  • CONCLUSION: Vitamin D affects enamel and dentin mineralization through different mechanisms.
  • It may affect the mineralization of dentin systemically while enamel mineralization may be regulated locally.
  • [MeSH-major] Dental Enamel / metabolism. Dentin / metabolism. Receptors, Calcitriol / metabolism. Tooth Calcification / physiology
  • [MeSH-minor] Animals. Immunohistochemistry. Incisor / metabolism. Incisor / ultrastructure. Mandible. Mice. Mice, Knockout. Tooth Eruption / physiology. X-Ray Microtomography

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19828979.001).
  • [ISSN] 1420-2433
  • [Journal-full-title] Frontiers of oral biology
  • [ISO-abbreviation] Front Oral Biol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Receptors, Calcitriol
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44. ||........ 19%  Wang C, Ren L, Peng L, Xu P, Dong G, Ye L: Effect of Wnt6 on human dental papilla cells in vitro. J Endod; 2010 Feb;36(2):238-43
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  • [Title] Effect of Wnt6 on human dental papilla cells in vitro.
  • Because the role of Wnt6 in tooth development was still unknown, the purpose of this study was to investigate the role of Wnt6 in tooth morphogenesis and dental tissue mineralization by elucidating its effect on human dental papilla cells (hDPCs) in vitro.
  • METHODS: Human dental papilla cells were enzymatically separated from tooth germs.
  • Wnt6-transduced changes in hDPC differentiation were investigated by evaluating alkaline phosphatase (ALPase) activity, by a mineralization assay, and analysis of mineralization-related gene expression including ALP, type I collagen (Col I), osteonectin (ON), osteopontin (OPN), bone sialoprotein (BSP), and dentin matrix protein-1 (DMP-1).
  • Wnt6 enhanced differentiation of hDPCs into functional odontoblast-like cells with up-regulated activity of ALPase and the expression of mineralization-related genes such as ALP, Col I, ON, OPN, BSP, and DMP-1.
  • Wnt6 overexpression also promoted the mineralization of hDPCs.
  • CONCLUSIONS: Our findings verified that Wnt6 plays an important role in tooth development by promoting hDPC differentiation, without significant effects on hDPC proliferation.
  • [MeSH-major] Cell Proliferation. Dental Papilla / physiology. Odontogenesis / physiology. Tooth Calcification / physiology. Wnt Proteins / physiology
  • [MeSH-minor] Alkaline Phosphatase / metabolism. Cell Differentiation / genetics. Cell Differentiation / physiology. Cells, Cultured. DNA, Complementary. Gene Expression Regulation, Developmental / physiology. Humans. Recombinant Proteins. Tooth Germ / cytology. Transduction, Genetic

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  • [Copyright] Copyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20113781.001).
  • [ISSN] 1878-3554
  • [Journal-full-title] Journal of endodontics
  • [ISO-abbreviation] J Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Recombinant Proteins; 0 / WNT6 protein, human; 0 / Wnt Proteins; EC 3.1.3.1 / Alkaline Phosphatase
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45. ||........ 19%  Ruschel HC, Ligocki GD, Flaminghi DL, Fossati AC: Microstructure of mineralized tissues in human primary teeth. J Clin Pediatr Dent; 2011;35(3):295-300
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  • [Title] Microstructure of mineralized tissues in human primary teeth.
  • The aim of this study was to analyze the structural characteristics of the mineralized dental tissues--enamel, dentin and cementum--in primary teeth and to correlate the histological aspects observed in function of the dental type--single-rooted or multi-rooted.
  • METHOD: Eighteen human primary noncarious teeth were sectioned in facial-lingual (single-rooted) and mesio-distal direction (multi-rooted).
  • One to three samples from each tooth were obtained.
  • Dead tracts in dentin and tertiary dentin were observed mainly in single-rooted teeth below areas of dental attrition.
  • Areas of cellular and acellular cementum were observed in the two dental types.
  • CONCLUSIONS: Primary teeth have some structural peculiarities and these should be investigated concerning the clinical repercussion.
  • [MeSH-major] Dental Cementum / ultrastructure. Dental Enamel / ultrastructure. Dentin / ultrastructure. Tooth Calcification / physiology
  • [MeSH-minor] Child. Child, Preschool. Humans. Tooth Root / anatomy & histology. Tooth, Deciduous / physiology. Tooth, Deciduous / ultrastructure

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  • (PMID = 21678673.001).
  • [ISSN] 1053-4628
  • [Journal-full-title] The Journal of clinical pediatric dentistry
  • [ISO-abbreviation] J Clin Pediatr Dent
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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46. ||........ 19%  Simmons LM, Montgomery J, Beaumont J, Davis GR, Al-Jawad M: Mapping the spatial and temporal progression of human dental enamel biomineralization using synchrotron X-ray diffraction. Arch Oral Biol; 2013 Nov;58(11):1726-34
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  • [Title] Mapping the spatial and temporal progression of human dental enamel biomineralization using synchrotron X-ray diffraction.
  • OBJECTIVE: The complex biological, physicochemical process of human dental enamel formation begins in utero and for most teeth takes several years to complete.
  • Lost enamel tissue cannot regenerate, therefore a better understanding of the spatial and temporal progression of mineralization of this tissue is needed in order to design improved in vivo mineral growth processes for regenerative dentistry and allow the possibility to grow a synthetic whole or partial tooth.
  • METHOD: Human dental enamel samples across a range of developmental stages available through archaeological collections have been used to explore the spatial and temporal progression of enamel biomineralization.
  • RESULTS: An inverse correlation was found between the spatial variation in mineral content and the distribution of crystallite organization and thickness as a function of time during enamel maturation.
  • CONCLUSION: During the mineralization of human dental enamel, the rate of mineral formation and mineral organization are not identical.
  • These findings provide detailed insights into mineral development in human dental enamel which can inform synthetic biomimetic approaches for the benefit of clinical dentistry.
  • [MeSH-major] Anthropology, Physical / methods. Dental Enamel / growth & development. Durapatite / chemistry. Tooth Calcification / physiology

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 24112740.001).
  • [ISSN] 1879-1506
  • [Journal-full-title] Archives of oral biology
  • [ISO-abbreviation] Arch. Oral Biol.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 91D9GV0Z28 / Durapatite
  • [Keywords] NOTNLM ; Biomineralization / Enamel / Hydroxyapatite / Preferred orientation / Synchrotron X-ray diffraction / Texture
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47. ||........ 19%  Goldberg AJ, Advincula MC, Komabayashi T, Patel PA, Mather PT, Goberman DG, Kazemi RB: Polypeptide-catalyzed biosilicification of dentin surfaces. J Dent Res; 2009 Apr;88(4):377-81
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  • In situ formation of mineral particles by biocatalysis would be advantageous for occluding dentin tubules to reduce permeability or for sealing of material-tooth interfaces.
  • [MeSH-major] Dentin / ultrastructure. Dentin Permeability / drug effects. Organosilicon Compounds / chemistry. Polylysine / chemistry. Tooth Calcification / drug effects
  • [MeSH-minor] Biocatalysis. Biomimetics. Dental Restoration, Permanent / methods. Humans. Molar

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  • (PMID = 19407161.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Organosilicon Compounds; 0 / tetramethyl orthosilicate; 25104-18-1 / Polylysine
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48. ||........ 19%  Chen L, Liu H, Sun W, Bai X, Karaplis AC, Goltzman D, Miao D: Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice. Clin Exp Pharmacol Physiol; 2011 Jun;38(6):395-402
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  • [Title] Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice.
  • 1. Though previous studies have shown that fibroblast growth factor 23 (FGF23) mRNA expression localizes in ameloblasts and odontoblasts in teeth, it is unclear what effect FGF23 overexpression has on dentin mineralization and dentinogenesis.
  • Toward this end, the phenotypes of mandibles and teeth were compared between 6-week-old FGF23 transgenic mice and their wild-type littermates by radiography, microcomputed tomography scanning, histology, histochemistry and immunohistochemistry.
  • 2. The mineral density was reduced in all teeth, including molars and incisors, and in the mandible, and the mineralized tooth volume in incisor and molars, and the mineralized cortical and alveolar bone volume in mandibles were decreased in FGF23 transgenic mice compared with their wild-type littermates.
  • The dental volume, reparative dentin area, the expression of dentin sialoprotein in dentin, and the deposition of type I collagen and osteocalcin in the dental matrix were significantly reduced.
  • 3. The results of the present study show that FGF23 overexpression plays a negative regulatory role on dentin mineralization and dentinogenesis.
  • [MeSH-major] Dentin / metabolism. Fibroblast Growth Factors / metabolism. Gene Expression Regulation, Developmental / physiology. Tooth Calcification / physiology
  • [MeSH-minor] Animals. Calcification, Physiologic. Extracellular Matrix Proteins / genetics. Extracellular Matrix Proteins / metabolism. Genotype. Mandible / anatomy & histology. Mice. Mice, Transgenic. Phosphoproteins / genetics. Phosphoproteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. Sialoglycoproteins / genetics. Sialoglycoproteins / metabolism

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  • [Copyright] © 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 21488937.001).
  • [ISSN] 1440-1681
  • [Journal-full-title] Clinical and experimental pharmacology & physiology
  • [ISO-abbreviation] Clin. Exp. Pharmacol. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein; 0 / fibroblast growth factor 23; 62031-54-3 / Fibroblast Growth Factors
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49. ||........ 19%  Tanimoto K, Kunimatsu R, Tanne Y, Huang YC, Michida M, Yoshimi Y, Miyauchi M, Takata T, Tanne K: Differential effects of amelogenin on mineralization of cementoblasts and periodontal ligament cells. J Periodontol; 2012 May;83(5):672-9
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  • [Title] Differential effects of amelogenin on mineralization of cementoblasts and periodontal ligament cells.
  • BACKGROUND: Amelogenin is a major component of developing extracellular enamel matrix proteins and plays a crucial role during the formation of tooth enamel.
  • The purpose of this study is to examine the effect of recombinant human full-length amelogenin (rh174) on the mineralization of human cementoblasts (HCEMs) and human periodontal ligament cells (HPDLs).
  • Mineralization of cells was evaluated by red dye staining.
  • In addition, the protein levels of OCN and BSP, ALP activity, and calcium deposition were enhanced, resulting in enhanced mineralization.
  • Conversely, there were no significant effects of rh174 on the mineralization of HPDLs.
  • CONCLUSION: The present study shows that rh174 enhances mineralization accompanied by upregulation of mineralization markers in HCEMs, whereas it has no effect on that in HPDLs, suggesting different effects of amelogenin on PDL and cementum.
  • [MeSH-major] Amelogenin / pharmacology. Dental Cementum / drug effects. Periodontal Ligament / drug effects. Tooth Calcification / drug effects

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  • (PMID = 21942790.001).
  • [ISSN] 1943-3670
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amelogenin; 0 / Integrin-Binding Sialoprotein; 0 / Recombinant Proteins; 104982-03-8 / Osteocalcin; EC 3.1.3.1 / Alkaline Phosphatase
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50. ||........ 19%  Diamanti E, Mathieu S, Jeanneau C, Kitraki E, Panopoulos P, Spyrou G, About I: Endoplasmic reticulum stress and mineralization inhibition mechanism by the resinous monomer HEMA. Int Endod J; 2013 Feb;46(2):160-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoplasmic reticulum stress and mineralization inhibition mechanism by the resinous monomer HEMA.
  • AIM: To investigate the expression of two endoplasmic reticulum (ER)-resident key chaperone proteins, ERdj5 and BiP, under the influence of resinous monomers and its relationship with the inhibition of mineralization caused by the monomer 2-hydroxyethyl methacrylate (HEMA).
  • These events may elucidate the mechanism by which HEMA inhibits the mineralization process.
  • [MeSH-major] Dental Pulp / drug effects. Endoplasmic Reticulum Stress. Methacrylates / adverse effects. Molecular Chaperones / metabolism. Odontoblasts / drug effects. Stress, Physiological. Tooth Calcification / drug effects
  • [MeSH-minor] Adolescent. Cells, Cultured. Dental Stress Analysis. Extracellular Matrix / drug effects. Extracellular Matrix Proteins / antagonists & inhibitors. Extracellular Matrix Proteins / metabolism. HSP40 Heat-Shock Proteins / metabolism. Heat-Shock Proteins / metabolism. Humans. Osteonectin / antagonists & inhibitors. Osteonectin / metabolism. Phosphoproteins / antagonists & inhibitors. Phosphoproteins / metabolism. Sialoglycoproteins / antagonists & inhibitors. Sialoglycoproteins / metabolism

  • HSDB. structure - 2-HYDROXYETHYL METHACRYLATE.
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  • [Copyright] © 2012 International Endodontic Journal.
  • (PMID = 22889382.001).
  • [ISSN] 1365-2591
  • [Journal-full-title] International endodontic journal
  • [ISO-abbreviation] Int Endod J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / ERdj5 protein, mouse; 0 / Extracellular Matrix Proteins; 0 / HSP40 Heat-Shock Proteins; 0 / Heat-Shock Proteins; 0 / Methacrylates; 0 / Molecular Chaperones; 0 / Osteonectin; 0 / Phosphoproteins; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein; 0 / molecular chaperone GRP78; 6E1I4IV47V / hydroxyethyl methacrylate
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