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1. Biomedical articles (top 50; 2010 to 2015)
1. Valizadeh S, Eil N, Ehsani S, Bakhshandeh H: Correlation between dental and cervical vertebral maturation in Iranian females. Iran J Radiol; 2012 Dec;10(1):1-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between dental and cervical vertebral maturation in Iranian females.
  • BACKGROUND: Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth.
  • OBJECTIVES: The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturation in Iranian females.
  • To determine the dental maturational stage, calcification of the mandibular teeth except for third molars were rated according to the method suggested by Demirjian et al.
  • Correlations between bone maturation and teeth calcification were showed by Spearman's correlation and Kendall's tau-b coefficients.
  • The association between cervical vertebral maturation and tooth calcification was greatest in the lateral incisor (odds ratio (OR) = 11, 95% confidence interval (CI): 6.6-18.3).
  • CONCLUSION: The relationship between calcification of teeth and maturation of cervical bones was significant.
  • Bone maturation can be predicted by using teeth calcification stages, especially in the second molar, first molar and lateral incisor.

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  • (PMID = 23599706.001).
  • [ISSN] 1735-1065
  • [Journal-full-title] Iranian journal of radiology : a quarterly journal published by the Iranian Radiological Society
  • [ISO-abbreviation] Iran J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3618898
  • [Keywords] NOTNLM ; Cervical Vertebrae / Radiography, Panoramic / Tooth Calcification
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2. Schroth RJ, Lavelle C, Tate R, Bruce S, Billings RJ, Moffatt ME: Prenatal vitamin D and dental caries in infants. Pediatrics; 2014 May;133(5):e1277-84
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  • [Title] Prenatal vitamin D and dental caries in infants.
  • OBJECTIVES: Inadequate maternal vitamin D (assessed by using 25-hydroxyvitamin D [25OHD]) levels during pregnancy may affect tooth calcification, predisposing enamel hypoplasia and early childhood caries (ECC).
  • The purpose of this study was to determine the relationship between prenatal 25OHD concentrations and dental caries among offspring during the first year of life.
  • Dental examinations were completed at 1 year of age while the parent/caregiver completed a questionnaire.
  • [MeSH-major] Dental Caries / prevention & control. Prenatal Care. Vitamin D / administration & dosage. Vitamin D / analogs & derivatives
  • [MeSH-minor] Adolescent. Adult. Cohort Studies. Dental Caries Activity Tests. Dental Enamel Hypoplasia / blood. Dental Enamel Hypoplasia / diagnosis. Dental Enamel Hypoplasia / prevention & control. Female. Humans. Pregnancy. Pregnancy Complications / blood. Pregnancy Complications / diagnosis. Prospective Studies. Urban Population. Vitamin D Deficiency / blood. Vitamin D Deficiency / diagnosis. Vulnerable Populations. Young Adult

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  • [Copyright] Copyright © 2014 by the American Academy of Pediatrics.
  • (PMID = 24753535.001).
  • [ISSN] 1098-4275
  • [Journal-full-title] Pediatrics
  • [ISO-abbreviation] Pediatrics
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1406-16-2 / Vitamin D; 64719-49-9 / 25-hydroxyvitamin D
  • [Keywords] NOTNLM ; early childhood caries / enamel hypoplasia / infant / vitamin D
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3. Foster BL, Nagatomo KJ, Tso HW, Tran AB, Nociti FH Jr, Narisawa S, Yadav MC, McKee MD, Millán JI, Somerman MJ: Tooth root dentin mineralization defects in a mouse model of hypophosphatasia. J Bone Miner Res; 2013 Feb;28(2):271-82
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  • [Title] Tooth root dentin mineralization defects in a mouse model of hypophosphatasia.
  • Tissue-nonspecific alkaline phosphatase (TNAP) is expressed in mineralizing tissues and functions to reduce pyrophosphate (PP(i) ), a potent inhibitor of mineralization.
  • Loss of TNAP function causes hypophosphatasia (HPP), a heritable disorder marked by increased PP(i) , resulting in rickets and osteomalacia.
  • Tooth root cementum defects are well described in both HPP patients and in Alpl(-/-) mice, a model for infantile HPP.
  • In Alpl(-/-) mice, dentin mineralization is specifically delayed in the root; however, reports from human HPP patients are variable and inconsistent regarding dentin defects.
  • TNAP was found to be highly expressed by mature odontoblasts, and Alpl(-/-) molar and incisor roots featured defective dentin mineralization, ranging from a mild delay to severely disturbed root dentinogenesis.
  • Lack of mantle dentin mineralization was associated with disordered and dysmorphic odontoblasts having disrupted expression of marker genes osteocalcin and dentin sialophosphoprotein.
  • The formation of, initiation of mineralization within, and rupture of matrix vesicles in Alpl(-/-) dentin matrix was not affected.
  • Osteopontin (OPN), an inhibitor of mineralization that contributes to the skeletal pathology in Alpl(-/-) mice, was present in the generally unmineralized Alpl(-/-) mantle dentin at ruptured mineralizing matrix vesicles, as detected by immunohistochemistry and by immunogold labeling.
  • However, ablating the OPN-encoding Spp1 gene in Alpl(-/-) mice was insufficient to rescue the dentin mineralization defect.
  • Administration of bioengineered mineral-targeting human TNAP (ENB-0040) to Alpl(-/-) mice corrected defective dentin mineralization in the molar roots.
  • These studies reveal that TNAP participates in root dentin formation and confirm that reduction of PP(i) during dentinogenesis is necessary for odontoblast differentiation, dentin matrix secretion, and mineralization.
  • [MeSH-major] Dentin / physiopathology. Hypophosphatasia / physiopathology. Tooth Calcification. Tooth Root / physiopathology

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  • [Copyright] Copyright © 2013 American Society for Bone and Mineral Research.
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  • (PMID = 22991301.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP-97858; United States / NIAMS NIH HHS / AR / R01 AR047908; United States / NIAMS NIH HHS / AR / R01 AR47908; United States / NIDCR NIH HHS / DE / R01 DE012889; United States / NIDCR NIH HHS / DE / R01 DE015109; United States / NIDCR NIH HHS / DE / R01 DE12889; United States / NIDCR NIH HHS / DE / R01DE15109; United States / Intramural NIH HHS / / Z99 AR999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 106441-73-0 / Osteopontin; EC 3.1.3.1 / Alkaline Phosphatase
  • [Other-IDs] NLM/ NIHMS407464; NLM/ PMC3541444
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4. McKee MD, Yadav MC, Foster BL, Somerman MJ, Farquharson C, Millán JL: Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization. J Dent Res; 2013 Aug;92(8):721-7
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  • [Title] Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.
  • Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood.
  • Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without TNAP lack acellular cementum, and have mineralization defects in dentin, enamel, and bone.
  • PHOSPHO1 is a phosphatase found within membrane-bounded matrix vesicles in mineralized tissues, and double ablation of Alpl and Phospho1 in mice leads to a complete absence of skeletal mineralization.
  • Here, we describe mineralization abnormalities in the teeth of Phospho1(-/-) mice, and in compound knockout mice lacking Phospho1 and one allele of Alpl (Phospho1(-/-);Alpl(+/-) ).
  • In wild-type mice, PHOSPHO1 and TNAP co-localized to odontoblasts at early stages of dentinogenesis, coincident with the early mineralization of mantle dentin.
  • In Phospho1 knockout mice, radiography, micro-computed tomography, histology, and transmission electron microscopy all demonstrated mineralization abnormalities of incisor dentin, with the most remarkable findings being reduced overall mineralization coincident with decreased matrix vesicle mineralization in the Phospho1(-/-) mice, and the almost complete absence of matrix vesicles in the Phospho1(-/-);Alpl(+/-) mice, whose incisors showed a further reduction in mineralization.
  • Results from this study support prominent non-redundant roles for both PHOSPHO1 and TNAP in dentin mineralization.
  • [MeSH-major] Alkaline Phosphatase / genetics. Dentin / enzymology. Phosphoric Monoester Hydrolases / genetics. Tooth Calcification / genetics
  • [MeSH-minor] Alleles. Alveolar Process / enzymology. Ameloblasts / enzymology. Animals. Apatites / analysis. Calcification, Physiologic / genetics. Dentinogenesis / genetics. Enamel Organ / enzymology. Extracellular Matrix / enzymology. Immunohistochemistry. Incisor / enzymology. Mice. Mice, Inbred C57BL. Mice, Inbred Strains. Mice, Knockout. Mice, Mutant Strains. Microscopy, Electron, Transmission. Molar / enzymology. Odontoblasts / enzymology. Osteoblasts / enzymology. Radiographic Image Enhancement. Tooth Germ / enzymology. X-Ray Microtomography

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  • (PMID = 23694930.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR53102; United States / NIDCR NIH HHS / DE / DE12889; Canada / Canadian Institutes of Health Research / / MOP97858; United States / NIAMS NIH HHS / AR / R01 AR053102; United States / NIDCR NIH HHS / DE / R01 DE012889; United Kingdom / Biotechnology and Biological Sciences Research Council / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apatites; EC 3.1.3.- / PHOSPHO1 protein, mouse; EC 3.1.3.- / Phosphoric Monoester Hydrolases; EC 3.1.3.1 / Alkaline Phosphatase; EC 3.1.3.1 / alkaline phosphatase 2, mouse
  • [Other-IDs] NLM/ PMC3711567
  • [Keywords] NOTNLM ; extracellular matrix / extracellular matrix proteins / matrix vesicles / phosphatase / tissue-non-specific alkaline phosphatase / tooth
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5. Moradian-Oldak J: Protein-mediated enamel mineralization. Front Biosci (Landmark Ed); 2012;17:1996-2023
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  • [Title] Protein-mediated enamel mineralization.
  • Enamel is a hard nanocomposite bioceramic with significant resilience that protects the mammalian tooth from external physical and chemical damages.
  • [MeSH-major] Dental Enamel / metabolism. Dental Enamel Proteins / metabolism. Tooth Calcification / physiology
  • [MeSH-minor] Amelogenesis Imperfecta / genetics. Amelogenesis Imperfecta / metabolism. Amelogenin / metabolism. Animals. Biomimetic Materials / therapeutic use. Dental Materials / therapeutic use. Extracellular Matrix Proteins / metabolism. Humans. Hydrogen-Ion Concentration. Minerals / metabolism. Peptide Hydrolases / metabolism. Protein Multimerization

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  • (PMID = 22652761.001).
  • [ISSN] 1093-4715
  • [Journal-full-title] Frontiers in bioscience (Landmark edition)
  • [ISO-abbreviation] Front Biosci (Landmark Ed)
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE-015644; United States / NIDCR NIH HHS / DE / DE-020099; United States / NIDCR NIH HHS / DE / DE-13414; United States / NIDCR NIH HHS / DE / R01 DE013414; United States / NIDCR NIH HHS / DE / R01 DE015644; United States / NIDCR NIH HHS / DE / R01 DE020099
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AMBN protein, human; 0 / AMTN protein, human; 0 / Amelogenin; 0 / Dental Enamel Proteins; 0 / Dental Materials; 0 / Extracellular Matrix Proteins; 0 / Minerals; 0 / tuftelin; EC 3.4.- / Peptide Hydrolases
  • [Other-IDs] NLM/ NIHMS398422; NLM/ PMC3442115
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6. Simmer JP, Richardson AS, Hu YY, Smith CE, Ching-Chun Hu J: A post-classical theory of enamel biomineralization… and why we need one. Int J Oral Sci; 2012 Sep;4(3):129-34
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  • They are hundreds of thousands times longer than they are wide, run parallel to each other, are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel.
  • In this review, we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape, orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane.
  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / chemistry. Tooth Calcification
  • [MeSH-minor] Ameloblasts / chemistry. Ameloblasts / cytology. Basement Membrane / chemistry. Crystallization. Dental Enamel Proteins / secretion. Humans

  • ResearchGate. author profiles.
  • (NIF). NIF Registry Automated Crawl Data: Resource: Registry .
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  • (PMID = 22996272.001).
  • [ISSN] 1674-2818
  • [Journal-full-title] International journal of oral science
  • [ISO-abbreviation] Int J Oral Sci
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE011301; United States / NIDCR NIH HHS / DE / DE061854
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Dental Enamel Proteins
  • [Other-IDs] NLM/ PMC3464985
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7. 'Tooth Calcification': Top Publications. BioMedLib Review OC; ;ToothCalcification:709661827. ISSN: 2331-5717. 2015/3/7; updates online.
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  • [Title] 'Tooth Calcification': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'tooth calcification'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 13 publications, and group two 716 publications.
  • Here are the top 7.
  • Stock SR et al: Sea urchin tooth mineralization: calcite present early in the aboral plumula.
  • Cooper IF et al: 'Organ or Tissue Functions' associated with 'Calcification Teeth': Top Publications.
  • Boughner JC et al: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).
  • He WD et al: [Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance].
  • Tian Z et al: Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity.
  • Surendran S et al: Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity.
  • Khavandgar Z et al: Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709661827.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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8. Lise DP, Gutiérrez C, da Rosa TP, Vieira LC: Bleaching options for pulp-calcified teeth: case history reports. Oper Dent; 2014 Nov-Dec;39(6):572-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bleaching options for pulp-calcified teeth: case history reports.
  • The aim of this article is to review some essential aspects of anterior tooth calcification and its esthetic treatment.

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  • (PMID = 25084109.001).
  • [ISSN] 1559-2863
  • [Journal-full-title] Operative dentistry
  • [ISO-abbreviation] Oper Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Chen J, Hu H, Guo J, Liu Z, Liu R, Li F, Zou S: Correlation between dental maturity and cervical vertebral maturity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Dec;110(6):777-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation between dental maturity and cervical vertebral maturity.
  • OBJECTIVE: The aim of this study was to investigate the association between dental and skeletal maturity.
  • Dental maturity was assessed by calcification stages of the mandibular canines, first and second premolars, and second molars, whereas skeletal maturity was estimated by the cervical vertebral maturation (CVM) stages.
  • The Spearman rank-order correlation coefficient was used to measure the association between CVM stage and dental calcification stage of individual teeth.
  • The Spearman rank-order correlation coefficients between dental maturity and cervical vertebral maturity ranged from 0.391 to 0.582 for girls and from 0.464 to 0.496 for boys (P < 0.05).
  • CONCLUSIONS: Tooth calcification stage was significantly correlated with cervical vertebral maturation stage.
  • Therefore, it is practical to consider the relationship between dental and skeletal maturity when planning orthodontic treatment.
  • [MeSH-major] Age Determination by Skeleton. Age Determination by Teeth
  • [MeSH-minor] Adolescent. Bicuspid / growth & development. Cephalometry. Cervical Vertebrae / growth & development. Child. China. Cohort Studies. Cuspid / growth & development. Dental Pulp Cavity / growth & development. Female. Humans. Male. Mandible. Molar / growth & development. Odontogenesis / physiology. Radiography, Dental, Digital. Radiography, Panoramic. Sex Factors. Tooth Apex / growth & development. Tooth Calcification / physiology. Tooth Crown / growth & development. Tooth Root / growth & development

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  • [Copyright] Copyright © 2010 Mosby, Inc. All rights reserved.
  • (PMID = 21112534.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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10. Acharya AB: Age estimation in Indians using Demirjian's 8-teeth method. J Forensic Sci; 2011 Jan;56(1):124-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Age estimation in Indians using Demirjian's 8-teeth method.
  • Demirjian's grading of tooth calcification is widely used to assess age of individuals with developing dentitions.
  • Conventionally, Demirjian's method utilized seven mandibular teeth on the left side.
  • This paper tested the 8-teeth method using 547 Indians (348 females, 199 males) aged 7-25 years.
  • This suggests that Demirjian's 8-teeth method also needs adaptation prior to use in diverse populations.
  • [MeSH-major] Age Determination by Teeth / methods
  • [MeSH-minor] Adolescent. Adult. Case-Control Studies. Child. European Continental Ancestry Group. Female. Forensic Dentistry / methods. Humans. India. Male. Radiography, Dental. Regression Analysis. Young Adult

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  • [Copyright] © 2010 American Academy of Forensic Sciences.
  • (PMID = 20854361.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Chindasombatjaroen J, Poomsawat S, Kakimoto N, Shimamoto H: Calcifying cystic odontogenic tumor and adenomatoid odontogenic tumor: radiographic evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol; 2012 Dec;114(6):796-803
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Location, border, relationship of the lesion with the impacted tooth, calcification patterns, tooth displacement, and root resorption were evaluated.
  • Three CCOTs and 7 AOTs enclosed impacted teeth.
  • Of these cases, the radiolucencies of 3 CCOTs and 1 AOT were attached to the impacted teeth at the cementoenamel junctions.
  • Three AOTs enclosed more portions of the roots, and the other 3 AOTs enclosed the entire teeth.
  • Calcification in CCOTs appeared as a thin radiopaque line (2 cases) and discrete radiopaque foci (1 case), whereas AOTs had numerous dispersed or clustered radiopaque foci (4 cases).
  • CONCLUSIONS: Radiolucency with numerous radiopaque foci (particularly when the radiolucency surrounds a portion of the root or entire tooth) is suggestive of an AOT rather than a CCOT.

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 23159119.001).
  • [ISSN] 2212-4411
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology and oral radiology
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Adenoameloblastoma
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12. Ahiko N, Baba Y, Tsuji M, Suzuki S, Kaneko T, Kindaichi J, Moriyama K: Investigation of maxillofacial morphology and dental development in hemifacial microsomia. Cleft Palate Craniofac J; 2015 Mar;52(2):203-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Investigation of maxillofacial morphology and dental development in hemifacial microsomia.
  • This study was conducted to characterize maxillofacial morphology and dental development in Japanese patients with HFM.
  • Main Outcome Measures : We used posteroanterior (PA) and lateral cephalograms obtained at the first visit to analyze maxillofacial morphology and orthopantomograms to compare dental development between the affected and unaffected sides.
  • Dental development was graded according to Nolla's stages of tooth calcification.
  • The difference in dental development between the affected and unaffected sides was significant at the mandibular molars and the mandibular canine.
  • The data also showed delayed calcification in the mandibular molars on the affected side.

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  • (PMID = 24617329.001).
  • [ISSN] 1545-1569
  • [Journal-full-title] The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
  • [ISO-abbreviation] Cleft Palate Craniofac. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; dental development / hemifacial microsomia / maxillofacial morphology
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13. Cossellu G, Biagi R, Pisani L, Barbieri V, Farronato G: Relationship between mandibular second molar calcification stages and cervical vertebrae maturity in Italian children and young adults. Eur J Paediatr Dent; 2014 Dec;15(4):355-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relationship between mandibular second molar calcification stages and cervical vertebrae maturity in Italian children and young adults.
  • AIM: The aim of this study was to investigate the relationship between the stages of calcification of the mandibular second molar and the stages of skeletal maturity among Italian children and young adults.
  • Dental maturity index (DM) was assessed by calcification stages of the mandibular second molars according to the Demirjian method; skeletal maturity was evaluated with cervical vertebrae maturation index (CVM) according to Hassel and Farman.
  • In case of females the end of the growth spurt it is not clearly associated with a dental maturity stage and needs to be stated with further parameters such as CVM.
  • [MeSH-major] Cervical Vertebrae / growth & development. Molar / physiology. Tooth Calcification / physiology

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  • (PMID = 25517579.001).
  • [ISSN] 1591-996X
  • [Journal-full-title] European journal of paediatric dentistry : official journal of European Academy of Paediatric Dentistry
  • [ISO-abbreviation] Eur J Paediatr Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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14. Surendran S, Thomas E: Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity. Am J Orthod Dentofacial Orthop; 2014 Jan;145(1):7-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity.
  • INTRODUCTION: The objective of this study was to determine whether dental calcification can be used as a first-level diagnostic tool for assessment of skeletal maturity.
  • Dental maturity was assessed through the calcification stages from panoramic radiographs of the mandibular canine, the first and second premolars, and the second molar.
  • RESULTS: Diagnostic ability was evaluated according to the dental maturation stages for each tooth for identification of the MP3 stages and the growth phases (prepubertal, pubertal, postpubertal) using positive likelihood ratios.
  • Dental maturation stage E of the first premolars and the combination of canine stage F, first premolar stage E, second premolar stage E, and second molar stage D (FEED) gave the highest values for identification of the prepubertal growth phase, and stage H of the second molar had the highest value for identification of the postpubertal growth phase.
  • CONCLUSIONS: Dental maturation assessment is only useful for diagnosis of the prepubertal and postpubertal growth phases.
  • [MeSH-major] Age Determination by Skeleton / methods. Tooth Calcification / physiology
  • [MeSH-minor] Adolescent. Bicuspid / growth & development. Bicuspid / radiography. Child. Cross-Sectional Studies. Cuspid / growth & development. Cuspid / radiography. Dental Pulp / growth & development. Dental Pulp / radiography. Epiphyses / growth & development. Epiphyses / radiography. Female. Finger Phalanges / growth & development. Finger Phalanges / radiography. Growth Plate / growth & development. Growth Plate / radiography. Humans. Likelihood Functions. Male. Mandible / radiography. Molar / growth & development. Molar / radiography. Predictive Value of Tests. Puberty / physiology. Radiographic Image Enhancement / methods. Radiography, Dental, Digital / methods. Radiography, Panoramic / methods. Sensitivity and Specificity. Tooth Apex / growth & development. Tooth Apex / radiography. Tooth Crown / growth & development. Tooth Crown / radiography. Tooth Root / growth & development. Tooth Root / radiography

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  • [Copyright] Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
  • [CommentIn] Am J Orthod Dentofacial Orthop. 2014 May;145(5):551-2 [24785914.001]
  • [CommentIn] Am J Orthod Dentofacial Orthop. 2014 May;145(5):552-3 [24785916.001]
  • (PMID = 24373650.001).
  • [ISSN] 1097-6752
  • [Journal-full-title] American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
  • [ISO-abbreviation] Am J Orthod Dentofacial Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. 'Tooth Calcification Function': Top Publications. BioMedLib Review OC; ;ToothCalcificationFunction:709661862. ISSN: 2331-5717. 2015/4/7; updates online.
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  • [Title] 'Tooth Calcification Function': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'tooth calcification function'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 13 publications, and group two 716 publications.
  • Here are the top 7.
  • Stock SR et al: Sea urchin tooth mineralization: calcite present early in the aboral plumula.
  • Cooper IF et al: 'Hormones' associated with 'Calcification Teeth': Top Publications.
  • Boughner JC et al: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).
  • Surendran S et al: Tooth mineralization stages as a diagnostic tool for assessment of skeletal maturity.
  • Scheurer E et al: Validation of reference data on wisdom tooth mineralization and eruption for forensic age estimation in living persons.
  • He WD et al: [Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance].
  • Khavandgar Z et al: Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709661862.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. Cooper IF, Siadaty MS: 'Organ or Tissue Functions' associated with 'Calcification Teeth': Top Publications. BioMedLib Review; OrganOrTissue;CalcificationTeeth:706343201. ISSN: 2331-5717. 2014/4/25
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  • [Title] 'Organ or Tissue Functions' associated with 'Calcification Teeth': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organ or Tissue Function' for 'calcification teeth'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organ or Tissue Function'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 24 publications, and group two 1326 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Hormones' associated with 'Calcification Teeth': Top Publications.
  • Stock SR et al: Sea urchin tooth mineralization: calcite present early in the aboral plumula.
  • Alvares K et al: Echinoderm phosphorylated matrix proteins UTMP16 and UTMP19 have different functions in sea urchin tooth mineralization.
  • Oshiro M et al: Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study.
  • Boskey AL et al: Cell culture systems for studies of bone and tooth mineralization.
  • Kuykendall KL et al: Permanent tooth calcification in chimpanzees (Pan troglodytes): patterns and polymorphisms.
  • Kuykendall KL: Dental development in chimpanzees (Pan troglodytes): the timing of tooth calcification stages.
  • Merwin DR et al: Sibling similarities in the tempo of human tooth mineralization.
  • Olze A et al: Forensic age estimation in living subjects: the ethnic factor in wisdom tooth mineralization.
  • Harris EF et al: Tooth mineralization standards for blacks and whites from the middle southern United States.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706343201.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. Cooper IF, Siadaty MS: 'Organ or Tissue Functions' associated with 'Troglodytes Troglodytes': Top Publications. BioMedLib Review; OrganOrTissue;TroglodytesTroglodytes:705943949. ISSN: 2331-5717. 2014/9/15
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  • [Title] 'Organ or Tissue Functions' associated with 'Troglodytes Troglodytes': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organ or Tissue Function' for 'troglodytes troglodytes'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organ or Tissue Function'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 1711 publications.
  • Here are the top 10.
  • Hopkins WD: Neuroanatomical asymmetries and handedness in chimpanzees (Pan troglodytes): a case for continuity in the evolution of hemispheric specialization.
  • Fukushima H et al: Neural correlates of face and object perception in an awake chimpanzee (Pan troglodytes) examined by scalp-surface event-related potentials.
  • Kuykendall KL et al: Permanent tooth calcification in chimpanzees (Pan troglodytes): patterns and polymorphisms.
  • Kuykendall KL: Dental development in chimpanzees (Pan troglodytes): the timing of tooth calcification stages.
  • Eder G: A longitudinal study of the kidney function of the chimpanzee (Pan troglodytes) in comparison with humans.
  • Ueno A et al: Facial responses to four basic tastes in newborn rhesus macaques (Macaca mulatta) and chimpanzees (Pan troglodytes).
  • Hopkins WD: Hemispheric specialization for local and global processing of hierarchical visual stimuli in chimpanzees (Pan troglodytes).
  • Lemmon WB et al: Continual sexual receptivity in the female chimpanzee (Pan troglodytes).
  • Oyen OJ: Masticatory function and histogenesis of the middle and upper face in chimpanzees (Pan troglodytes).
  • Boughner JC et al: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705943949.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. Wei W, Peng Z, Deng J, Zhang W, Mao J: [Study on in vitro biomineralization of enamel-binding peptide]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2014 Feb;31(1):132-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present the binding ability of a new peptide (CMPQVMPMC-) with dental enamel after being evaluated in the present study.
  • [MeSH-major] Dental Enamel / chemistry. Peptides / chemistry. Tooth Calcification

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  • (PMID = 24804499.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Peptides
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19. Cooper IF, Siadaty MS: 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Calcification Teeth': Top Publications. BioMedLib Review; BodyPartOrgan;CalcificationTeeth:706368195. ISSN: 2331-5717. 2014/6/26
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  • [Title] 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Calcification Teeth': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Body Part Organ or Organ Component' for 'calcification teeth'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Body Part Organ or Organ Component'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 18 publications, and group two 2847 publications.
  • Here are the top 10.
  • Bahetwar SK et al: A biochemical and histopathological evaluation of generalized pulp calcification in young permanent teeth.
  • Weinmann JP et al: Experimental Studies in Calcification: III. The Effect of Parathyroid Hormone on the Alveolar Bone and Teeth of the Normal and Rachitic Rat.
  • Schopf PM: [Root calcification and tooth eruption in the mixed dentition. A study in panoramic x-rays].
  • Mappes MS et al: An example of regional variation in the tempos of tooth mineralization and hand-wrist ossification.
  • Gvozdenović-Simović V: [Mandibular tooth calcification].
  • Kaqueler JC et al: [Effect of sodium selenate on the calcification of teeth and jaws of young rats. Studies using tetracycline].
  • Holtgrave EA et al: Tablet fluoridation influences the calcification of primary tooth pulp.
  • Nakamura Y et al: Calcification of degenerating tissues in the periodontal ligament during tooth movement.
  • Lima JE de O et al: [Influence of salivary glands parotid and submandibulary in the eruption, growing and calcification of the incisive and molar teeth of rats (author's transl)].
  • Tsuchiya T et al: [Observation on calcification of necrotic tissue in pressure side of periodontal membrane incident to experimental tooth movement].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706368195.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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20. Streckbein P, Reichert I, Verhoff MA, Bödeker RH, Kähling C, Wilbrand JF, Schaaf H, Howaldt HP, May A: Estimation of legal age using calcification stages of third molars in living individuals. Sci Justice; 2014 Dec;54(6):447-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Estimation of legal age using calcification stages of third molars in living individuals.
  • The objective of this study was to determine the extent to which third molar calcification stages assessed on panoramic X-rays could be useful as additional criteria for forensic age estimation in living individuals, focusing on the legally important ages 17 and 18.
  • Individuals with the lowest calcification stage of all present molars in stage H were ≥18 years with a likelihood of ≥99.05% in the female (n=388), and ≥99.24% in the male (n=482) population.
  • The lowest calcification stage of all present third molars proved to be useful as an additional reliable criterion for the determination of an age ≥18 years.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2014 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 25498932.001).
  • [ISSN] 1355-0306
  • [Journal-full-title] Science & justice : journal of the Forensic Science Society
  • [ISO-abbreviation] Sci. Justice
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Keywords] NOTNLM ; Age assessment / Demirjian's scale / Forensic age estimation / Forensic odontology / Forensic science / Third molar development
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21. Burt NM, Sauer N, Fenton T: Testing the Demirjian and the international Demirjian dental aging methods on a mixed ancestry urban American subadult sample from Detroit, MI. J Forensic Sci; 2011 Sep;56(5):1296-301
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testing the Demirjian and the international Demirjian dental aging methods on a mixed ancestry urban American subadult sample from Detroit, MI.
  • This paper tests the Demirjian and international Demirjian dental aging methods for forensic use when ancestry and ethnicity are unknown.
  • [MeSH-major] Age Determination by Teeth / methods. Continental Population Groups. Tooth Calcification

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  • [Copyright] © 2011 American Academy of Forensic Sciences.
  • (PMID = 21777240.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Galić I, Vodanović M, Janković S, Mihanović F, Nakaš E, Prohić S, Galić E, Brkić H: Dental age estimation on Bosnian-Herzegovinian children aged 6-14 years: evaluation of Chaillet's international maturity standards. J Forensic Leg Med; 2013 Jan;20(1):40-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dental age estimation on Bosnian-Herzegovinian children aged 6-14 years: evaluation of Chaillet's international maturity standards.
  • BACKGROUND: Dental age estimation in children plays an important role in forensic dentistry.
  • It generally overestimates dental age in many populations.
  • OBJECTIVES: The aim of this study was to evaluate the applicability of Chaillet's international scores in the dental age assessment on Bosnian Herzegovinian (BH) children.
  • The dental ages for both genders were compared to the chronological ages through a paired t-test.
  • The absolute accuracy of residuals between the dental and chronological age were 0.65 ± 0.52 years for girls (Median: 0.52 years) and 0.73 ± 0.60 years for boys (Median: 0.57 years).
  • CONCLUSION: The Polynomial compound formula was recommended to predict dental age with more accuracy for results of international maturity standards on BH children.
  • [MeSH-major] Age Determination by Teeth / methods. Tooth Calcification

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  • [Copyright] Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 23217374.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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23. Celik S, Zeren C, Celikel A, Yengil E, Altan A: Applicability of the Demirjian method for dental assessment of southern Turkish children. J Forensic Leg Med; 2014 Jul;25:1-5
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  • [Title] Applicability of the Demirjian method for dental assessment of southern Turkish children.
  • The aims of this study were to evaluate the applicability and accuracy of the Demirjian technique for assessing southern Turkish children; to analyze the sexual dimorphism of dental age in the studied groups; and to define the relationship between the dental age and the degree of mineralization in mandibular permanent tooth in southern Turkish children.
  • The mean difference between dental and chronological age was calculated for each age and sex group.
  • The same observer re-examined 700 teeth three months after the first examination.
  • The results were evaluated with the intraclass correlation test and both measurements were statistically significantly similar with each other(R = 0.982, p = 0.0001). .Dental age (DA) and chronological age (CA) were consistent for boys in the 16-16.9 age group and for girls in the 9-9.9 and 15-15.9 age groups.
  • From this study, we can conclude that dental age varies across ethnic populations.
  • Additionally, dental maturation varies across different regions of the same country.
  • [MeSH-major] Age Determination by Teeth / methods. Radiography, Panoramic. Tooth Calcification

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  • [Copyright] Copyright © 2014. Published by Elsevier Ltd.
  • (PMID = 24931852.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Age estimation / Demirjian method / Dental age / Forensic anthropology population data / Forensic odontology
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24. Qing M, Qiu L, Gao Z, Bhandari K: The chronological age estimation of third molar mineralization of Han population in southwestern China. J Forensic Leg Med; 2014 May;24:24-7
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  • [Title] The chronological age estimation of third molar mineralization of Han population in southwestern China.
  • The purpose of the study was to estimate the chronology of third molar mineralization in Han population of southwestern China and find its unique characteristics so that it would provide a reference in several legal cases like forensic age estimation.
  • (1) The chronological mineralization age of third molars of Han population in Southwestern China is similar to the Turkish and the Japanese, was earlier than the Austrian and Han of South China, but later than the Spanish. (2) The mineralization timing of the third molars between two sides in maxilla or mandible has no significant differences in the same gender group. (3) There is no significant difference in mineralization of third molars between male and female, except for tooth 48 in Demirjian's stage E. (4) The mineralization of third molar in maxilla is earlier than mandible.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 24794846.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; Demirjian's staging method / Forensic age estimation / Third molar mineralization
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25. Guo YC, Yan CX, Lin XW, Zhang WT, Zhou H, Pan F, Wei L, Tang Z, Liang F, Chen T: The influence of impaction to the third molar mineralization in northwestern Chinese population. Int J Legal Med; 2014 Jul;128(4):659-65
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  • [Title] The influence of impaction to the third molar mineralization in northwestern Chinese population.
  • Age estimation by third molar mineralization has been developed for a period of time.
  • Recent studies showed that impaction status has an influence on the rate of the third molar mineralization in Europids and male Black African populations.
  • In this regard, the present study was conducted to determine whether the impaction status could delay the chronological process of third molar mineralization in northwestern Chinese population too.
  • Mineralization stage and impaction status were determined for all third molars.
  • The results prove that impacted third molars show significant slower mineralization than non-impacted ones at stages D and E in both males and females of northwestern Chinese population.
  • It is recommended to consider the influence of impaction on the rate of third molar mineralization for dental age estimation.

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  • (PMID = 24532176.001).
  • [ISSN] 1437-1596
  • [Journal-full-title] International journal of legal medicine
  • [ISO-abbreviation] Int. J. Legal Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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26. Kumar S, Singla A, Sharma R, Virdi MS, Anupam A, Mittal B: Skeletal maturation evaluation using mandibular second molar calcification stages. Angle Orthod; 2012 May;82(3):501-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Skeletal maturation evaluation using mandibular second molar calcification stages.
  • OBJECTIVE: To investigate (1) the relationships between the stages of mandibular second molar calcification and skeletal maturity; and (2) whether second molar calcification stages can be used as a reliable diagnostic tool to determine skeletal maturity.
  • MATERIALS AND METHODS: Samples were derived from panoramic radiographs and lateral cephalograms of 300 subjects (137 males and 163 females) with ages ranging from 9 to 18 years, and estimates of dental maturity (Demirjian Index [DI]) and skeletal maturity (cervical vertebrae maturation indicators [CVMI]) were made.
  • [MeSH-major] Age Determination by Teeth. Molar / growth & development. Tooth Calcification / physiology

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  • (PMID = 21899377.001).
  • [ISSN] 1945-7103
  • [Journal-full-title] The Angle orthodontist
  • [ISO-abbreviation] Angle Orthod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Boughner JC, Dean MC, Wilgenbusch CS: Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes). Am J Phys Anthropol; 2012 Dec;149(4):560-71
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  • [Title] Permanent tooth mineralization in bonobos (Pan paniscus) and chimpanzees (P. troglodytes).
  • The timing of tooth mineralization in bonobos (Pan paniscus) is virtually uncharacterized.
  • Analysis of these developmental features in bonobos and the possible differences with its sister species, the chimpanzee (P. troglodytes), is important to properly quantify the normal ranges of dental growth variation in closely related primate species.
  • Understanding this variation among bonobo, chimpanzee and modern human dental development is necessary to better contextualize the life histories of extinct hominins.
  • This study tests whether bonobos and chimpanzees are distinguished from each other by covariance among the relative timing and sequences of tooth crown initiation, mineralization, root extension, and completion.
  • Using multivariate statistical analyses, we compared the relative timing of permanent tooth crypt formation, crown mineralization, and root extension between 34 P. paniscus and 80 P. troglodytes mandibles radiographed in lateral and occlusal views.
  • Covariance among our 12 assigned dental scores failed to statistically distinguish between bonobos and chimpanzees.
  • Dental scores covaried similarly between the incisors, as well as between both premolars.
  • Conversely, covariance among dental scores distinguished the canine and each of the three molars not only from each other, but also from the rest of the anterior teeth.
  • Our study showed no significant differences in the relative timing of permanent tooth crown and root formation between bonobos and chimpanzees.
  • [MeSH-major] Pan paniscus / growth & development. Pan troglodytes / growth & development. Tooth Calcification / physiology
  • [MeSH-minor] Age Factors. Animals. Cluster Analysis. Cuspid / anatomy & histology. Cuspid / metabolism. Female. Male. Molar / anatomy & histology. Molar / metabolism. Multivariate Analysis. Principal Component Analysis. Tooth Crown / anatomy & histology. Tooth Crown / metabolism. Tooth Root / anatomy & histology. Tooth Root / metabolism

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 23097136.001).
  • [ISSN] 1096-8644
  • [Journal-full-title] American journal of physical anthropology
  • [ISO-abbreviation] Am. J. Phys. Anthropol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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28. Cooper IF, Siadaty MS: 'Genetic Functions' associated with 'Troglodytes Troglodytes': Top Publications. BioMedLib Review; GeneticFunction;TroglodytesTroglodytes:705943219. ISSN: 2331-5717. 2014/7/15
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  • [Title] 'Genetic Functions' associated with 'Troglodytes Troglodytes': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Genetic Function' for 'troglodytes troglodytes'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Genetic Function'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 17 publications, and group two 3712 publications.
  • Here are the top 10.
  • Bowden R et al: Genomic tools for evolution and conservation in the chimpanzee: Pan troglodytes ellioti is a genetically distinct population.
  • Hopkins WD et al: Neuroanatomical correlates of handedness for tool use in chimpanzees (Pan troglodytes): implication for theories on the evolution of language.
  • Hopkins WD: Neuroanatomical asymmetries and handedness in chimpanzees (Pan troglodytes): a case for continuity in the evolution of hemispheric specialization.
  • Wong H et al: The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
  • Hopkins WD et al: A polymorphic indel containing the RS3 microsatellite in the 5' flanking region of the vasopressin V1a receptor gene is associated with chimpanzee (Pan troglodytes) personality.
  • Kuykendall KL et al: Permanent tooth calcification in chimpanzees (Pan troglodytes): patterns and polymorphisms.
  • Paravatou-Petsota M et al: Diagrammatic representation for chromosomal mutagenesis studies. III. Radiation-induced rearrangements in Pan troglodytes (chimpanzee).
  • Vogel ER et al: Functional ecology and evolution of hominoid molar enamel thickness: Pan troglodytes schweinfurthii and Pongo pygmaeus wurmbii.
  • Videan EN et al: Bipedality in chimpanzee (Pan troglodytes) and bonobo (Pan paniscus): testing hypotheses on the evolution of bipedalism.
  • Dixson AF et al: Sexual behavior, sexual swelling, and penile evolution in chimpanzees (Pan troglodytes).

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705943219.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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29. Poché RA, Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik JH, DePinho RA, Bartlett JD, Dickinson ME: Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One; 2012;7(1):e30357
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  • Furthermore, we determined that both the FoxO1 and Smad3 mutant teeth exhibit changes in the expression of similar cohort of genes encoding enamel matrix proteins required for proper enamel development.
  • This study is the first to define an essential role for the FoxO family of transcription factors in tooth development and provides a new molecular entry point which will allow researchers to delineate novel genetic pathways regulating the process of biomineralization which may also have significance for studies of human tooth diseases such as amelogenesis imperfecta.
  • [MeSH-major] Amelogenesis / genetics. Dental Enamel / metabolism. Forkhead Transcription Factors / physiology. Tooth Calcification / genetics
  • [MeSH-minor] Animals. Calcification, Physiologic / genetics. Calcification, Physiologic / physiology. Hardness Tests. Integrases / genetics. Mice. Mice, Inbred BALB C. Mice, Inbred C57BL. Mice, Knockout. Smad3 Protein / genetics. Smad3 Protein / metabolism. Smad3 Protein / physiology. Tooth Diseases / genetics. Tooth Diseases / pathology. Transcription Factors / genetics. Transcription Factors / physiology

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  • (NIF). NIF Registry Automated Crawl Data: Resource: Registry .
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
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  • (PMID = 22291941.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA16672; United States / NIBIB NIH HHS / EB / P20EB0070769; United States / NCI NIH HHS / CA / P30 CA016672; United States / NIDCR NIH HHS / DE / R01 DE016276; United States / NIBIB NIH HHS / EB / R01EB005173
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Foxo1 protein, mouse; 0 / Smad3 Protein; 0 / Smad3 protein, mouse; 0 / Transcription Factors; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases
  • [Other-IDs] NLM/ PMC3265481
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30. Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML: Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci; 2011 Dec;119 Suppl 1:149-57
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  • These results indicate that ameloblasts undergo widespread molecular changes during the maturation stage of amelogenesis and hence provide a basis for future functional investigations into the mechanistic basis of enamel mineralization.
  • [MeSH-major] Ameloblasts / cytology. Amelogenesis / physiology. Enamel Organ / physiology. Gene Expression Profiling. Gene Expression Regulation, Developmental / genetics. Tooth Calcification / genetics

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  • [Copyright] © 2011 Eur J Oral Sci.
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  • (PMID = 22243241.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE013404; United States / NIDCR NIH HHS / DE / DE019629; United States / NIGMS NIH HHS / GM / GM072447; United States / NIDCR NIH HHS / DE / R01 DE013404; United States / NIDCR NIH HHS / DE / R01 DE013404-09; United States / NIDCR NIH HHS / DE / R01 DE019629; United States / NIDCR NIH HHS / DE / R01 DE019629-03; United States / NIGMS NIH HHS / GM / R01 GM072477; United States / NIGMS NIH HHS / GM / R01 GM072477-05S1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Other-IDs] NLM/ NIHMS323965; NLM/ PMC3286129
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31. Lacruz RS, Smith CE, Bringas P Jr, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML: Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol; 2012 May;227(5):2264-75
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  • [Title] Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling.
  • Dental enamel, the most highly mineralized tissue in mammals, differs from other calcifying systems in that the formative cells (ameloblasts) lack remodeling activity and largely degrade and resorb the initial extracellular matrix.
  • Enamel mineralization requires that ameloblasts undergo a profound functional switch from matrix-secreting to maturational (calcium transport, protein resorption) roles as mineralization progresses.
  • To identify the genetic events driving enamel mineralization, we conducted genome-wide transcript profiling of the developing enamel organ from rat incisors and highlight over 300 genes differentially expressed during maturation.
  • Using multiple bioinformatics analyses, we identified groups of maturation-associated genes whose functions are linked to key mineralization processes including pH regulation, calcium handling, and matrix turnover.
  • Subsequent qPCR and Western blot analyses revealed that a number of solute carrier (SLC) gene family members were up-regulated during maturation, including the novel protein Slc24a4 involved in calcium handling as well as other proteins of similar function (Stim1).
  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / chemistry. Dental Enamel / metabolism. Gene Expression Profiling / methods. Genome. Tooth Calcification / genetics

  • HSDB. structure - CALCIUM, ELEMENTAL.
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  • [Copyright] Copyright © 2011 Wiley Periodicals, Inc.
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  • (PMID = 21809343.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE006988; United States / NIDCR NIH HHS / DE / DE013045; United States / NIDCR NIH HHS / DE / DE013404; United States / NIDCR NIH HHS / DE / DE019629; United States / NIDDK NIH HHS / DK / DK058563; United States / NIDDK NIH HHS / DK / DK077162; United States / NIGMS NIH HHS / GM / GM072447; United States / NIDCR NIH HHS / DE / R01 DE006988; United States / NIDCR NIH HHS / DE / R01 DE006988-26; United States / NIDCR NIH HHS / DE / R01 DE013045; United States / NIDCR NIH HHS / DE / R01 DE013404; United States / NIDCR NIH HHS / DE / R01 DE013404-05; United States / NIDCR NIH HHS / DE / R01 DE019629; United States / NIDCR NIH HHS / DE / R01 DE019629-01; United States / NIDCR NIH HHS / DE / R01 DE019629-02; United States / NIDDK NIH HHS / DK / R01 DK058563; United States / NIDDK NIH HHS / DK / R01 DK058563-10; United States / NIDDK NIH HHS / DK / R01 DK077162; United States / NIDDK NIH HHS / DK / R01 DK077162-05; United States / NIGMS NIH HHS / GM / R01 GM072477; United States / NIGMS NIH HHS / GM / R01 GM072477-05; United States / NIDCR NIH HHS / DE / R37 DE013045; United States / NIDCR NIH HHS / DE / R37 DE013045-10
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] SY7Q814VUP / Calcium
  • [Other-IDs] NLM/ NIHMS314583; NLM/ PMC3243804
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32. Khavandgar Z, Alebrahim S, Eimar H, Tamimi F, McKee MD, Murshed M: Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3. J Dent Res; 2013 Apr;92(4):358-64
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  • [Title] Local regulation of tooth mineralization by sphingomyelin phosphodiesterase 3.
  • A recessive mutation called fragilitas ossium (fro) in the Smpd3 gene leads to impaired mineralization of bone and tooth extracellular matrix (ECM) in fro/fro mice.
  • In teeth from fro/fro mice at various neonatal ages, radiography and light and electron microscopy showed delayed mantle dentin mineralization and a consequent delay in enamel formation as compared with that in control +/fro mice.
  • These tooth abnormalities progressively improved with time.
  • Using a transgenic mouse rescue model (fro/fro; Col1a1-Smpd3) in which Smpd3 expression is driven by a murine Col1a1 promoter fragment active in osteoblasts and odontoblasts, we demonstrate a complete correction of the tooth mineralization delays.
  • In conclusion, analysis of these data demonstrates that Smpd3 expression in odontoblasts is required for tooth mineralization.
  • [MeSH-major] Dental Enamel / enzymology. Osteogenesis Imperfecta / enzymology. Sphingomyelin Phosphodiesterase / metabolism. Tooth Calcification / physiology

  • MedlinePlus Health Information. consumer health - Osteogenesis Imperfecta.
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  • (PMID = 23428435.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 123310
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.1.4.12 / Smpd3 protein, mouse; EC 3.1.4.12 / Sphingomyelin Phosphodiesterase
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33. Khorate MM, Dinkar AD, Ahmed J: Accuracy of age estimation methods from orthopantomograph in forensic odontology: a comparative study. Forensic Sci Int; 2014 Jan;234:184.e1-8
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  • In forensic odontology, age estimation based on tooth development is universally accepted method.
  • Furthermore, in this study by applying all these methods to one regional population, we have attempted to present dental age estimation methodology best suited for the Goan Indian population.
  • [MeSH-major] Age Determination by Teeth / methods. Radiography, Panoramic. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 24139310.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Keywords] NOTNLM ; Age estimation / Dental age / Forensic anthropology population data / Forensic odontology / Methods / Orthopantomograph
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34. Lopez TT, Arruda CP, Rocha M, Rosin AS, Michel-Crosato E, Biazevic MG: Estimating ages by third molars: stages of development in Brazilian young adults. J Forensic Leg Med; 2013 Jul;20(5):412-8
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  • Differences were found in the stages of tooth formation between male and female, but differences were not observed between the left and right sides.
  • We found that both DT and MST underestimated the ages in about 6 months, depending on the used classification and number of teeth.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 23756509.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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35. Cantekin K, Yilmaz Y, Demirci T, Celikoglu M: Morphologic analysis of third-molar mineralization for eastern Turkish children and youth. J Forensic Sci; 2012 Mar;57(2):531-4
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  • [Title] Morphologic analysis of third-molar mineralization for eastern Turkish children and youth.
  • To date, there has been no chronological age estimation according to third-molar mineralization in eastern Turkish children and adolescents.
  • Regression analysis was performed to obtain regression formulae for dental age calculation with chronological age.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / radiography. Tooth Calcification

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  • [Copyright] © 2011 American Academy of Forensic Sciences.
  • (PMID = 22211957.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Bagherpour A, Anbiaee N, Partovi P, Golestani S, Afzalinasab S: Dental age assessment of young Iranian adults using third molars: A multivariate regression study. J Forensic Leg Med; 2012 Oct;19(7):407-12
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  • [Title] Dental age assessment of young Iranian adults using third molars: A multivariate regression study.
  • Radiologic assessment of the mineralisation stage of third molars is of particular importance, with regard to the relevant age group.
  • To attain a referral database and regression equations for dental age estimation of unaccompanied minors in an Iranian population was the goal of this study.
  • With Spearman correlation coefficient, correlation between the scores of all four wisdom teeth, was evaluated.
  • Taking into consideration gender, location and number of wisdom teeth, regression formulae were arrived at.
  • CONCLUSION: Use of population-specific standards is recommended as a means of improving the accuracy of forensic age estimates based on third molars mineralisation.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
  • (PMID = 22920764.001).
  • [ISSN] 1878-7487
  • [Journal-full-title] Journal of forensic and legal medicine
  • [ISO-abbreviation] J Forensic Leg Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. Maled V, Manjunatha B, Patil K, Balaraj BM: The chronology of third molar root mineralization in south Indian population. Med Sci Law; 2014 Jan;54(1):28-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The chronology of third molar root mineralization in south Indian population.
  • The aim of present study was to determine the chronology of third molar root mineralization and to establish south Indian reference data.
  • Therefore, a cross-sectional study was undertaken by evaluating 192 intraoral periapical radiographs in order to assess the root mineralization status of the mandibular third molar of south Indian individuals (101 males and 91 females) between the age of 13 and 25.
  • The range, mean age, standard deviation, Student t test and percentile distributions are presented for each stage of mineralization.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification. Tooth Root / growth & development

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  • (PMID = 23966355.001).
  • [ISSN] 0025-8024
  • [Journal-full-title] Medicine, science, and the law
  • [ISO-abbreviation] Med Sci Law
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; age estimation / forensic odontology / identification / radiography / root mineralization / south Indian / third molar
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38. Legović M, Sasso A, Legović I, Brumini G, Cabov T, Slaj M, Vancura I, Lapter M: The reliability of chronological age determination by means of mandibular third molar development in subjects in Croatia. J Forensic Sci; 2010 Jan;55(1):14-8
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  • The frequencies of different stages of mineralization and the mean value of the mineralization of the mandibular third molars with regard to age, gender, and size of the mandible were determined and the coefficient of correlation determined between the age of the subject and the stage of development of the mandibular molars.
  • Statistically significant correlation was determined between mineralization of the mandibular third molar and chronological age of the subjects (boys, mandibular left third molar r = 0.779, right third molar r = 0.793; girls, mandibular left third molar r = 0.746, right third molar r = 0.725).
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • (PMID = 20002266.001).
  • [ISSN] 1556-4029
  • [Journal-full-title] Journal of forensic sciences
  • [ISO-abbreviation] J. Forensic Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Li G, Ren J, Zhao S, Liu Y, Li N, Wu W, Yuan S, Wang H: Dental age estimation from the developmental stage of the third molars in western Chinese population. Forensic Sci Int; 2012 Jun 10;219(1-3):158-64
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  • [Title] Dental age estimation from the developmental stage of the third molars in western Chinese population.
  • The purpose of this study is to provide reference data about estimating dental age from third molars of the western Chinese population for comparing with other populations and being applied to the age estimation of western Chinese juveniles and adolescents.
  • The mineralization status of the third molars was assessed using the formation stages described by Demirjian et al. with two modifications.
  • This study provided reference data for the age estimation of western Chinese juveniles and adolescents by the mineralization stages of the third molar.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 22265462.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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40. de Oliveira FT, Capelozza AL, Lauris JR, de Bullen IR: Mineralization of mandibular third molars can estimate chronological age--Brazilian indices. Forensic Sci Int; 2012 Jun 10;219(1-3):147-50
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  • [Title] Mineralization of mandibular third molars can estimate chronological age--Brazilian indices.
  • The aim of this study was to determine if the chronology of third molar mineralization could be an accurate indicator of estimated age in a sample Brazilian population.
  • If so, mineralization could determine the probability of an individual being 18 years or older.
  • The study evaluated 407 panoramic radiographs of males and females from the past 5 years in order to assess the mineralization status of the mandibular third molars.
  • The results indicated a strong correlation between chronological age and the mineralization of the mandibular third molars.
  • The results indicated that modern Brazilian generation tends to demonstrate an earlier mandibular third molar mineralization than older Brazilian generation and people of other nationalities.
  • The probability that an individual with third molar mineralization stage H had reached an age of 18 years or older was 96.8-98.6% for males and females, respectively.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification

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  • [Copyright] Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 22257966.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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41. Kirsch T: Biomineralization--an active or passive process? Connect Tissue Res; 2012;53(6):438-45
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  • Physiological mineralization is restricted to tissues, such as bones, teeth, and certain areas of cartilage.
  • Pathological or ectopic mineralization can occur in many soft tissues, including articular cartilage, cardiovascular tissues, kidney, ligaments, and tendons, and can lead to serious problems.
  • Therefore, the understanding of factors and mechanisms that regulate the mineralization process is essential for the development of novel therapeutic strategies to prevent or inhibit ectopic mineralization.
  • This review will discuss some of the mechanisms and factors that regulate physiological mineralization and their potential roles in ectopic mineralization.
  • Finally, potential therapeutic approaches for the treatment of ectopic mineralization are being discussed.
  • [MeSH-major] Calcification, Physiologic. Calcinosis / metabolism. Tooth Calcification

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  • [CommentIn] Connect Tissue Res. 2012;53(6):437 [23145942.001]
  • (PMID = 22992051.001).
  • [ISSN] 1607-8438
  • [Journal-full-title] Connective tissue research
  • [ISO-abbreviation] Connect. Tissue Res.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / R01AR046245; United States / NIAMS NIH HHS / AR / R01AR049074
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
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42. Fang PA, Lam RS, Beniash E: Relationships between dentin and enamel mineral at the dentino-enamel boundary: electron tomography and high-resolution transmission electron microscopy study. Eur J Oral Sci; 2011 Dec;119 Suppl 1:120-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / metabolism. Dentin / metabolism. Tooth Calcification / physiology

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  • [Copyright] © 2011 Eur J Oral Sci.
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  • (PMID = 22243237.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE016703; United States / NIDCR NIH HHS / DE / R01 DE016703-06; United States / NIDCR NIH HHS / DE / R01-DE016703
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Other-IDs] NLM/ NIHMS354587; NLM/ PMC3277257
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43. Smith CE, Hu Y, Richardson AS, Bartlett JD, Hu JC, Simmer JP: Relationships between protein and mineral during enamel development in normal and genetically altered mice. Eur J Oral Sci; 2011 Dec;119 Suppl 1:125-35
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  • Klk4 null mice showed normal mineral acquisition up to early maturation, but the input of new volatiles in mid to late maturation caused the final mineralization to slow below normal levels.
  • [MeSH-major] Amelogenesis / physiology. Dental Enamel / chemistry. Dental Enamel Proteins / metabolism. Tooth Calcification / physiology

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  • [Copyright] © 2011 Eur J Oral Sci.
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  • (PMID = 22243238.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE011301; United States / NIDCR NIH HHS / DE / DE016276; United States / NIDCR NIH HHS / DE / DE019775; United States / NIDCR NIH HHS / DE / R01 DE016276; United States / NIDCR NIH HHS / DE / R01 DE016276-05; United States / NIDCR NIH HHS / DE / R01 DE019775; United States / NIDCR NIH HHS / DE / R01 DE019775-04; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Ambn protein, mouse; 0 / Dental Enamel Proteins; 0 / enamel matrix proteins; 0 / tuftelin; 91D9GV0Z28 / Durapatite; EC 3.4.21.- / Kallikreins; EC 3.4.21.- / kallikrein 4; EC 3.4.24.- / Matrix Metalloproteinase 20
  • [Other-IDs] NLM/ NIHMS354103; NLM/ PMC3295546
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44. Sahlstrand P, Lith A, Hakeberg M, Norén JG: Timing of mineralization of homologues permanent teeth--an evaluation of the dental maturation in panoramic radiographs. Swed Dent J; 2013;37(3):111-9
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  • [Title] Timing of mineralization of homologues permanent teeth--an evaluation of the dental maturation in panoramic radiographs.
  • An explanation to these variations could be that the start of the enamel mineralization differs between homologues teeth.
  • The aim of this study was to compare the dental development between homologues teeth in digital panoramic radiographs (PRs),from children aged 7 to 11 years, using the Gleiser & Hunt method on second and third molars and to calculate the crown/root ratio for the mandibular premolars.77 PRs, from individuals between 7.3 and 11.0 years of age, were studied.
  • Differences in developmental stages between homologues teeth (second and third molars) were studied.
  • A possible explanation to the variations in expressivity of MIH may be a result of differences in the start of mineralization between homologues teeth.
  • Timing of mineralization of homologues permanent teeth--An evaluation of the dental maturation in panoramic radiographs.
  • [MeSH-major] Age Determination by Teeth. Dental Enamel Hypoplasia / physiopathology. Tooth Calcification / physiology

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  • (PMID = 24341164.001).
  • [ISSN] 0347-9994
  • [Journal-full-title] Swedish dental journal
  • [ISO-abbreviation] Swed Dent J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Sweden
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45. Zeng DL, Wu ZL, Cui MY: Chronological age estimation of third molar mineralization of Han in southern China. Int J Legal Med; 2010 Mar;124(2):119-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronological age estimation of third molar mineralization of Han in southern China.
  • In order to study the chronology of age of third molar mineralization of Han in southern China, Demirjian staging method was used to determine the stage of four third molars (18, 28, 38, 48) mineralization in 3,100 Han in southern China aged 4.1-26.9 years based on radiological evidence from digital orthopantomograms.
  • Results show that there was no significant difference in mineralization between 18 and 28 and 38 and 48 of male or female.
  • At stages B, E, F, G, and H, the mineralization mean age of male 18 was 0.54, 0.50, 0.76, 0.92, and 0.58 years earlier than that of female, respectively.
  • At stages E, F, G, and H, the mineralization mean age of male 28 was 0.51, 0.76, 0.92, and 0.49 years earlier than that of female, respectively.
  • After reviewing the literature, the chronological mineralization age of 48, at stages D to G, of Han in southern China was 1 to 4.6 years earlier than that of Japanese and 1 to 3 years earlier than that of German.
  • (1) in the same gender group of Han in southern China, the mineralization ages between two sides in upper or lower jaw are very similar, and (2) the chronology mean age and complete time of third molar mineralization of male were earlier than that of female.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Tooth Calcification
  • [MeSH-minor] Adolescent. Adult. Child. Child, Preschool. China. Ethnic Groups. Female. Forensic Dentistry. Humans. Male. Radiography, Dental, Digital. Radiography, Panoramic. Sex Characteristics. Young Adult

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  • (PMID = 19908057.001).
  • [ISSN] 1437-1596
  • [Journal-full-title] International journal of legal medicine
  • [ISO-abbreviation] Int. J. Legal Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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46. Olze A, Pynn BR, Kraul V, Schulz R, Heinecke A, Pfeiffer H, Schmeling A: Studies on the chronology of third molar mineralization in First Nations people of Canada. Int J Legal Med; 2010 Sep;124(5):433-7
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  • [Title] Studies on the chronology of third molar mineralization in First Nations people of Canada.
  • One main criterion for dental age estimation in the relevant age group is the evaluation of third molar mineralization.
  • In the present study, we determined the stages of third molar mineralization in 347 female and 258 male First Nations people of Canada aged 11 to 29 years based on radiological evidence from 605 conventional orthopantomograms.
  • The results presented here provide useful data on the mineralization stages of third molars that can be used for forensic estimation of the minimum and most probable ages including the range of scatter of investigated persons.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / radiography. Tooth Calcification

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  • (PMID = 20623297.001).
  • [ISSN] 1437-1596
  • [Journal-full-title] International journal of legal medicine
  • [ISO-abbreviation] Int. J. Legal Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Kalyva M, Papadimitriou S, Tziafas D: Transdentinal stimulation of tertiary dentine formation and intratubular mineralization by growth factors. Int Endod J; 2010 May;43(5):382-92
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  • [Title] Transdentinal stimulation of tertiary dentine formation and intratubular mineralization by growth factors.
  • AIM: To evaluate the effects of recombinant growth factors on tertiary dentine formation and intratubular mineralization after their application on deep dentinal cavities in dog's teeth.
  • The dentinal responses regarding tertiary dentine formation and intratubular mineralization were assessed after 3 and 8 weeks, respectively, using light and scanning electron microscopy.
  • RESULTS: The group treated with transforming growth factor-beta1 (TGF-beta1) and, to a lesser extent, the one treated with osteogenic protein-1 (OP-1) showed significantly greater (P < 0.05) tertiary dentine formation and intratubular mineralization over an 8-week period when compared with the control and the other experimental groups.
  • CONCLUSION: Treatment of exposed dentinal tubules with biologically active molecules might induce intratubular mineralization and tertiary dentine formation.
  • [MeSH-major] Dentin, Secondary / drug effects. Intercellular Signaling Peptides and Proteins / pharmacology. Tooth Calcification / drug effects
  • [MeSH-minor] Acid Etching, Dental. Animals. Antibodies, Monoclonal / diagnostic use. Bone Morphogenetic Protein 7 / pharmacology. Dental Cavity Preparation / methods. Dentin Permeability / drug effects. Dogs. Fibroblast Growth Factor 2 / pharmacology. Humans. Insulin-Like Growth Factor I / pharmacology. Male. Microscopy, Electron, Scanning. Phosphoric Acids / chemistry. Recombinant Proteins. Time Factors. Transforming Growth Factor beta1 / immunology. Transforming Growth Factor beta1 / pharmacology

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  • (PMID = 20518931.001).
  • [ISSN] 1365-2591
  • [Journal-full-title] International endodontic journal
  • [ISO-abbreviation] Int Endod J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Bone Morphogenetic Protein 7; 0 / Intercellular Signaling Peptides and Proteins; 0 / Phosphoric Acids; 0 / Recombinant Proteins; 0 / Transforming Growth Factor beta1; 103107-01-3 / Fibroblast Growth Factor 2; 67763-96-6 / Insulin-Like Growth Factor I; E4GA8884NN / phosphoric acid
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48. Karataş OH, Öztürk F, Dedeoğlu N, Çolak C, Altun O: Radiographic evaluation of third-molar development in relation to the chronological age of Turkish children in the southwest Eastern Anatolia region. Forensic Sci Int; 2013 Oct 10;232(1-3):238.e1-5
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  • To study the chronological age of third-molar mineralisation of Turkish children from the southwest Eastern Anatolia region, the Demirjian staging method was used to determine the stage of the mineralisation of four third molars (18, 28, 38 and 48) and to compare third-molar development by sex and age with the results of previous studies.
  • Regression analysis was performed to obtain regression formulae for calculating the dental and the chronological age.
  • The results showed that there was no significant difference in mineralisation between 18 and 28 and 38 and 48 in males or females.
  • For both sexes, the dental age was lower than the chronological age.
  • In the whole population, the boys' and the girls' dental ages were 0.84 years and 0.16 years earlier, respectively, than their chronological ages.
  • The use of third-molar teeth as a developmental marker is suitable, particularly when comparing the obtained standard deviation with other skeletal-age calculation techniques.
  • [MeSH-major] Age Determination by Teeth / methods. Molar, Third / growth & development. Molar, Third / radiography. Tooth Calcification

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  • [Copyright] Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 24001572.001).
  • [ISSN] 1872-6283
  • [Journal-full-title] Forensic science international
  • [ISO-abbreviation] Forensic Sci. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Keywords] NOTNLM ; Age estimation / Chronological age / Dental age / Dental mineralisation / Third molar
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49. Zou W, Hunter N, Swain MV: Application of polychromatic µCT for mineral density determination. J Dent Res; 2011 Jan;90(1):18-30
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  • Accurate assessment of mineral density (MD) provides information critical to the understanding of mineralization processes of calcified tissues, including bones and teeth.
  • High-resolution three-dimensional assessment of the MD of teeth has been demonstrated by relatively inaccessible synchrotron radiation microcomputed tomography (SRµCT).
  • [MeSH-major] Tooth Calcification / physiology. X-Ray Microtomography / methods

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  • (PMID = 20858779.001).
  • [ISSN] 1544-0591
  • [Journal-full-title] Journal of dental research
  • [ISO-abbreviation] J. Dent. Res.
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE015272
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Phosphates; 0 / Polymers; 0 / Potassium Compounds; 16068-46-5 / potassium phosphate; 91D9GV0Z28 / Durapatite
  • [Other-IDs] NLM/ PMC3144098
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50. Zhang J, Wang Z, Jiang Y, Niu Z, Fu L, Luo Z, Cooper PR, Smith AJ, He W: Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro. Exp Cell Res; 2015 Mar 15;332(2):259-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The transcription factor Nuclear Factor I-C (NFIC) has been implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity.
  • Over-expression of NFIC increased cell proliferation, mineralization nodule formation and alkaline phosphatase (ALP) activity in SCAPs.
  • In contrast, knockdown of NFIC by si-RNA inhibited the mineralization capacity of SCAPs and down-regulated the expression of odontogenic-related markers.
  • [MeSH-major] Adult Stem Cells / physiology. Cell Differentiation. Cell Proliferation. Dental Papilla / cytology. NFI Transcription Factors / physiology
  • [MeSH-minor] Adolescent. Alkaline Phosphatase / metabolism. Cells, Cultured. Humans. Tooth Calcification

  • ResearchGate. author profiles.
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  • [Copyright] Copyright © 2015 Elsevier Inc. All rights reserved.
  • (PMID = 25668322.001).
  • [ISSN] 1090-2422
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / NFI Transcription Factors; 0 / NFIC protein, human; EC 3.1.3.1 / Alkaline Phosphatase
  • [Keywords] NOTNLM ; Differentiation / Nuclear factor / Proliferation / SCAPs
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