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1. Biomedical articles (top 50; 2010 to 2015)
1. Chen S, Levin RA, Gartner JA: Medication adherence and enrollment in a consumer-driven health plan. Am J Manag Care; 2010 Feb;16(2):e43-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The continuation rate was relatively high for all drug classes, although the CDHP cohort had a lower probability of continuing cardiac and cholesterol drugs.
  • Consumer-driven health plan patients took slightly longer on average to refill their first prescription in the post-year for cardiac, hypertension, cholesterol, and thyroid drugs.
  • The compliance rate dropped over time in both cohorts, but the reduction was bigger among CDHP patients for 3 drug classes (adjusted ratio of the odds ratios was 0.77, 0.78, and 0.69 for asthma, cardiac, and cholesterol drugs, respectively).

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  • (PMID = 20148609.001).
  • [ISSN] 1936-2692
  • [Journal-full-title] The American journal of managed care
  • [ISO-abbreviation] Am J Manag Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. Sertogullarindan B, Ozbay B, Gumrukcuoglu HA, Akil MA, Bilgin MH, Yasar M: A case of viral myocarditis presenting with acute asthma attack. J Clin Med Res; 2012 Jun;4(3):224-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of viral myocarditis presenting with acute asthma attack.
  • Cardiac asthma is commonly observed in elderly patients with left heart failure.
  • We report a young case of viral myocarditis mimicking acute asthma attack.
  • CASE PRESENTATION: A 27-year-old young man with a history of asthma presented to the pulmonary department of our hospital with dyspnea, left sided chest pain, cough, wheezing.
  • Asthma was diagnosed and treated, however his respiratory complaints have persisted.
  • Laboratory evaluations revealed that elevated cardiac enzymes, Echocardiogram showed global hypokinesia in the left ventricle and a decrease of ejection fraction.
  • We concluded that viral myocarditis can present itself like an acute asthma attack.

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  • (PMID = 22719812.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3376884
  • [Keywords] NOTNLM ; Asthma / Diagnosis / Myocarditis
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3. Eliahu S, Martín-Gil A, Perez de Lara MJ, Pintor J, Camden J, Weisman GA, Lecka J, Sévigny J, Fischer B: 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. J Med Chem; 2010 Apr 22;53(8):3305-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extracellular nucleotides can modify the production or drainage of the aqueous humor via activation of P2 receptors and therefore affect the intraocular pressure (IOP).
  • Analogue 9 was more effective at reducing IOP than several common glaucoma drugs and represents a promising alternative to timolol maleate, which cannot be used for the treatment of patients suffering from asthma or cardiac problems.

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  • (PMID = 20337495.001).
  • [ISSN] 1520-4804
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 49460; United States / NIDCR NIH HHS / DE / R01 DE007389; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / P2RY1 protein, human; 0 / Purinergic P2 Receptor Agonists; 0 / Receptors, Purinergic P2Y1; 61D2G4IYVH / Adenosine Diphosphate; 8L70Q75FXE / Adenosine Triphosphate
  • [Other-IDs] NLM/ NIHMS668785; NLM/ PMC4358770
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4. Perugi G, Quaranta G, Belletti S, Casalini F, Mosti N, Toni C, Dell'Osso L: General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J Affect Disord; 2015 Jan 1;170:95-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases.
  • BACKGROUND: Patients with bipolar disorder (BD) suffer from greater physical morbidity and mortality than the general population.
  • METHOD: The study sample comprised of 347 patients who met DSM-IV-TR criteria for BD I (n=207, 59.7%), BD II or Cyclothymic Disorder (n=140, 40.3).
  • Diagnostic information was collected by means of the Structured Clinical Interview for DSM-IV Axis I Disorders- Clinical Version (SCID-I), and information about personal and family history were collected by the Semi-Structured Interview for Mood Disorder-Revised (SIMD-R).
  • RESULTS: The most commonly reported GMCs were: Headache, Hypercholesterolemia (>200mg/dl), Chronic Constipation, Obesity, Arterial Hypertension (BP >140/90 mmHg), Hypothyroidism, Allergic Rhino-Conjunctivitis, Irritable Bowel Syndrome, Hypertriglyceridemia (>150 mg/dl), Metabolic Syndrome, Hiatus Hernia, Dysmenorrhea, Urticaria, Atopic Dermatitis, Psoriasis, Seborrheic Dermatitis, Diabetes Mellitus, Bronchial Asthma, Cardiac Arrhythmias, Biliary Lithiasis, and COPD.

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  • [Copyright] Copyright © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 25237732.001).
  • [ISSN] 1573-2517
  • [Journal-full-title] Journal of affective disorders
  • [ISO-abbreviation] J Affect Disord
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; Autoimmunity / Bipolar disorder / General medical conditions / Metabolic disorders
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5. Tanabe T, Rozycki HJ, Kanoh S, Rubin BK: Cardiac asthma: new insights into an old disease. Expert Rev Respir Med; 2012 Dec;6(6):705-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma: new insights into an old disease.
  • Cardiac asthma has been defined as wheezing, coughing and orthopnea due to congestive heart failure.
  • The clinical distinction between bronchial asthma and cardiac asthma can be straight forward, except in patients with chronic lung disease coexisting with left heart disease.
  • Pulmonary edema and pulmonary vascular congestion have been thought to be the primary causes of cardiac asthma but most patients have a poor response to diuretics.
  • There appears to be limited effectiveness of classical asthma medications like bronchodilators or corticosteroids in treating cardiac asthma.
  • [MeSH-major] Cough / physiopathology. Dyspnea / physiopathology. Heart Failure / physiopathology. Respiratory Sounds / physiopathology

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  • (PMID = 23234454.001).
  • [ISSN] 1747-6356
  • [Journal-full-title] Expert review of respiratory medicine
  • [ISO-abbreviation] Expert Rev Respir Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-2 Receptor Agonists; 0 / Angiotensin Receptor Antagonists; 0 / Angiotensin-Converting Enzyme Inhibitors; 0 / Antibodies, Monoclonal, Humanized; 0 / Bronchodilator Agents; 0 / Diuretics; GR88G0I6UL / Ipratropium
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6. Cooper IF, Siadaty MS: 'Hormones' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; Hormone;AsthmaCardiac:705919996. ISSN: 2331-5717. 2014/6/6
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  • [Title] 'Hormones' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Hormone' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Hormone'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 28 publications, and group two 6438 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Hormones' associated with 'Asthma Cardiac': Top Publications.
  • Rosero SZ et al: Asthma and the risk of cardiac events in the Long QT syndrome. Long QT Syndrome Investigative Group.
  • Jarcho S: Rostan on asthma in the aged (cardiac asthma), 1818.
  • Zecevic D et al: [Effects of the new brondilatator reproterol on the cardiac function during treatment of bronchial asthma and chronic obstructive bronchitis (author's transl)].
  • TOMOMATSU T: [SYMPOSIUM ON CIRCULATORY DISORDERS OF THE LUNG. (5). CARDIAC ASTHMA].
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.
  • Tanabe T et al: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Spreng P et al: [Siderophages in the sputum: contribution to the differential diagnosis of cardiac asthma and bronchial asthma].
  • MLCZOCH F: [BRONCHIAL ASTHMA AND CARDIAC ASTHMA--AN OLD SUBJECT IN THE LIGHT OF NEW DATA].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705919996.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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7. Effing T: Action plans and case manager support may hasten recovery of symptoms following an acute exacerbation in patients with chronic obstructive pulmonary disease (COPD). J Physiother; 2012;58(1):60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Action plans and case manager support may hasten recovery of symptoms following an acute exacerbation in patients with chronic obstructive pulmonary disease (COPD).
  • Exclusion criteria were a primary diagnosis of asthma or cardiac disease, or presence of disease that would affect mortality or participation (eg, confusion).
  • INTERVENTIONS: Both groups received usual care and brief nurse-led education about management of their disease.

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  • [Copyright] Copyright © 2012 Australian Physiotherapy Association. Published by .. All rights reserved.
  • [CommentOn] Thorax. 2011 Nov;66(11):977-84 [21785156.001]
  • (PMID = 22341386.001).
  • [ISSN] 1836-9553
  • [Journal-full-title] Journal of physiotherapy
  • [ISO-abbreviation] J Physiother
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Australia
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8. Rosen S: Cardiac tamponade presenting as refractory asthma. Glob Adv Health Med; 2013 Jan;2(1):18-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac tamponade presenting as refractory asthma.
  • Asthma has numerous etiologies, and successful treatment requires a proper diagnosis.
  • Changes in weather and exposure to dust can make treatment of asthma difficult.
  • This case exemplifies a diagnostic dilemma associated with bronchospasm; bronchospasm can have an occult cardiac etiology.
  • This case is that of a 40-year-old female Ghanaian woman with a lifelong history of asthma.
  • She was found to have cardiac tamponade with secondary "cardiac asthma."
  • The cardiac effusion was due to previously unknown renal failure from hyper-tension.
  • The patient was referred for dialysis and 1 year later was well without any recurrence of significant cardiac effusions.
  • Bedside ultrasound has great utility for the diagnosis of cardiac tamponade.

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  • (PMID = 24278840.001).
  • [ISSN] 2164-957X
  • [Journal-full-title] Global advances in health and medicine : improving healthcare outcomes worldwide
  • [ISO-abbreviation] Glob Adv Health Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3833587
  • [Keywords] NOTNLM ; Bronchospasm / asthma / atypical asthma / bedside ultra-sound / cardiac asthma / cardiac tamponade / case report
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9. Tanabe T, Kanoh S, Moskowitz WB, Rubin BK: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung. Chest; 2012 Nov;142(5):1274-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • BACKGROUND: Cardiac asthma describes symptoms of airflow obstruction due to heart failure.
  • Blood TGF- b 1 concentration correlates with ventricular remodeling in cardiac disease, and TGF- β decreases after repair.
  • Phosphorylation of Smad in NHBE cells was determined by Western blotting.Mice given doxorubicin developed cardiac failure, and their airways were histologically examined.
  • CONCLUSIONS: TGF- β from cardiomyoblasts or from the failing heart can cause airway squamous metaplasia via Smad signaling, and this is blocked by anti-TGF- b antibody and reversed when cardiac cells are removed from culture.
  • This appears to be an important mechanism for airflow obstruction with heart failure, sometimes described as cardiac asthma.
  • [MeSH-minor] Analysis of Variance. Animals. Blotting, Western. Bronchi / cytology. Coculture Techniques. DNA Primers. Doxorubicin. Enzyme-Linked Immunosorbent Assay. Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism. Humans. Immunohistochemistry. Male. Mice. Mice, Inbred C57BL. Myocytes, Cardiac / metabolism. Phosphorylation. Protein Precursors / metabolism. Rats. Real-Time Polymerase Chain Reaction. Signal Transduction. Smad Proteins / metabolism

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  • (PMID = 22505689.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Protein Precursors; 0 / Smad Proteins; 0 / Transforming Growth Factor beta; 60108-77-2 / involucrin; 80168379AG / Doxorubicin; EC 1.2.1.9 / Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
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10. Buckner K: Cardiac asthma. Immunol Allergy Clin North Am; 2013 Feb;33(1):35-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma.
  • Cardiac dyspnea, especially if present only with exercise, is often confused with asthma and exercise-induced bronchospasm.
  • Cardiac dyspnea or asthma is the consequence of pulmonary edema due to pulmonary venous hypertension and not due to asthmatic bronchoconstriction.
  • [MeSH-major] Asthma / diagnosis. Dyspnea / diagnosis. Dyspnea / etiology. Heart Failure / complications

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23337063.001).
  • [ISSN] 1557-8607
  • [Journal-full-title] Immunology and allergy clinics of North America
  • [ISO-abbreviation] Immunol Allergy Clin North Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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11. Zaĭtseva OV: [The approaches to diagnostics and therapy of allergic rhinitis]. Vestn Otorinolaringol; 2011;(5):62-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Allergic rhinitis is a common disease of great socio-economic significance.
  • The treatment of this condition is carried out on an individual basis depending on the clinical course of the disease; it includes prevention of contacts with the allergen, medicamental and immunotherapy.
  • The principal pharmaceuticals used to treat the patients include oral and intranasal H1 anti-histaminic preparations, intranasal corticosteroids, intranasal cromones, anti-leukotrien agents, and specific subcutaneous immunotherapy.
  • Glencet (levocetirizine) is one of the modern antihistaminic preparations of the second generation having an advantage over other drugs for the treatment of allergic rhinitis in that it may be prescribed to the patients presenting with concomitant bronchial asthma and cardiac diseases.

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  • (PMID = 22334929.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Histamine H1 Antagonists, Non-Sedating; 6U5EA9RT2O / levocetirizine; YO7261ME24 / Cetirizine
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12. Pagnoux C, Mahendira D, Laskin CA: Fertility and pregnancy in vasculitis. Best Pract Res Clin Rheumatol; 2013 Feb;27(1):79-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The potential impact of vasculitis therapies, particularly cyclophosphamide, has been examined to some extent, but data are limited on the possible impact of the disease itself on fertility.
  • Most maternal complications during pregnancy are indeed due to vasculitis damage: hypertension in Takayasu arteritis (TAK) or granulomatosis with polyangiitis (GPA)/microscopic polyangiitis (MPA) with renal insufficiency, asthma or cardiac damage in eosinophilic granulomatosis with polyangiitis (EGPA) and subglottic and/or bronchial stenosis(es) in GPA.
  • Pregnancy loss can occur in about 10% of cases in GPA, up to 20% in EGPA, 20-30% in Behçet's disease and up to 25% in TAK, and several studies found high rates of preterm births, at least with some vasculitides.

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 23507059.001).
  • [ISSN] 1532-1770
  • [Journal-full-title] Best practice & research. Clinical rheumatology
  • [ISO-abbreviation] Best Pract Res Clin Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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13. Gagnon-Audet AA, Poirier P, Turcotte H, Martin J, Bastien M, Simard S, Boulet LP: Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects. Clin Invest Med; 2013;36(5):E255-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects.
  • The relationship between asthma and cardiac dysfunction in severely obese subjects is unknown, although it has been hypothesized that cardiac dysfunction may contribute to increase airway hyper-responsiveness (AHR).
  • Indices of heart rate variability and overall cardiac function were similar in subjects with or without AHR but grade 2 left ventricular diastolic dysfunction was more prevalent in subjects with AHR (p=0.037).
  • CONCLUSIONS: Altered cardiac function, dysglycemia and dyslipidemia do not seem to be significantly associated with AHR in severely obese subjects in contrast to systemic inflammation.
  • [MeSH-major] Asthma / physiopathology. Heart Diseases / physiopathology. Heart Rate. Obesity / physiopathology

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  • (PMID = 24088331.001).
  • [ISSN] 1488-2353
  • [Journal-full-title] Clinical and investigative medicine. Médecine clinique et experimentale
  • [ISO-abbreviation] Clin Invest Med
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP-102585
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Bronchoconstrictor Agents; 0 / Lipids; 0W5ETF9M2K / Methacholine Chloride; 114471-18-0 / Natriuretic Peptide, Brain; 9007-41-4 / C-Reactive Protein
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14. Cooper IF, Siadaty MS: 'Steroids' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; Steroid;AsthmaCardiac:705938032. ISSN: 2331-5717. 2014/5/7
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  • [Title] 'Steroids' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'steroid' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'steroid'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 28 publications, and group two 5470 publications.
  • Here are the top 10.
  • Rosero SZ et al: Asthma and the risk of cardiac events in the Long QT syndrome. Long QT Syndrome Investigative Group.
  • Jarcho S: Rostan on asthma in the aged (cardiac asthma), 1818.
  • Zecevic D et al: [Effects of the new brondilatator reproterol on the cardiac function during treatment of bronchial asthma and chronic obstructive bronchitis (author's transl)].
  • TOMOMATSU T: [SYMPOSIUM ON CIRCULATORY DISORDERS OF THE LUNG. (5). CARDIAC ASTHMA].
  • Tanabe T et al: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Spreng P et al: [Siderophages in the sputum: contribution to the differential diagnosis of cardiac asthma and bronchial asthma].
  • MLCZOCH F: [BRONCHIAL ASTHMA AND CARDIAC ASTHMA--AN OLD SUBJECT IN THE LIGHT OF NEW DATA].
  • Stupnitskiĭ AA: [Heart activity in patients with cardiac asthma on the basis of phonocardiographic data].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705938032.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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15. Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; OrganicChemical;AsthmaCardiac:705786856. ISSN: 2331-5717. 2014/5/28
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  • [Title] 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Organic Chemical' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Organic Chemical'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 23 publications, and group two 6137 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications.
  • Vilsvik JS et al: Effect of atenolol on ventilatory and cardiac function in asthma.
  • Milner AD et al: Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
  • Martinez-Sabater H et al: Can adenosine cause asthma-like symptoms in patients with cardiac arrhythmias receiving atenolol?.
  • Al-Hillawi AH et al: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and slow release terbutaline for asthma.
  • Harrison P: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and terbutaline for asthma.
  • HILDEN T: The effect of tetraethylammonium bromide (etylon) on cardiac asthma and acute pulmonary oedema.
  • Martelli NA et al: Asthma, cardiac arrhythmias, and albuterol aerosol.
  • Wilcox PG et al: Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma.
  • Meluzín J et al: [Cardiac asthma after nifedipine and diltiazem].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705786856.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. Cooper IF, Siadaty MS: 'Pharmacologic Substances' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; PharmacologicSubstance;AsthmaCardiac:707071873. ISSN: 2331-5717. 2014/3/4
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  • [Title] 'Pharmacologic Substances' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Pharmacologic Substance' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Pharmacologic Substance'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 25 publications, and group two 6249 publications.
  • Here are the top 10.
  • Vilsvik JS et al: Effect of atenolol on ventilatory and cardiac function in asthma.
  • Thottathil P et al: Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists.
  • Milner AD et al: Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
  • Martinez-Sabater H et al: Can adenosine cause asthma-like symptoms in patients with cardiac arrhythmias receiving atenolol?.
  • Al-Hillawi AH et al: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and slow release terbutaline for asthma.
  • Harrison P: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and terbutaline for asthma.
  • Mukharliamov NM et al: [Possibilities for using peripheral vasodilator agents in cardiac asthma and threatened pulmonary edema].
  • Takatsu T et al: [Management of congestive heart failure (2). Diuretic administration and vasodilator therapy of cardiac asthma and pulmonary edema (cardiac load reduction) with special reference to SQ 14225 (captopril)].
  • Martelli NA et al: Asthma, cardiac arrhythmias, and albuterol aerosol.
  • Wilcox PG et al: Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707071873.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. Cooper IF, Siadaty MS: 'Therapeutic or Preventive Procedures' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; TherapeuticOrPreventive;AsthmaCardiac:705479096. ISSN: 2331-5717. 2014/4/30
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  • [Title] 'Therapeutic or Preventive Procedures' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'therapeutic or preventive procedure' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'therapeutic or preventive procedure'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 15 publications, and group two 5622 publications.
  • Here are the top 9.
  • Perera GA et al: THE RELATION OF POSTURAL HEMODILUTION TO PAROXYSMAL DYSPNEA.
  • REINIKAINEN M et al: [A CASE OF CARDIAC ASTHMA SUCCESSFULLY TREATED WITH INTERMITTENT POSITIVE PRESSURE BREATHING].
  • Thottathil P et al: Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists.
  • Harding AV et al: Biofeedback training of cardiac acceleration; effects on airway resistance in bronchial asthma.
  • Gol'dberg GA et al: [Therapeutic use of nitroglycerin in pulmonary edema and cardiac asthma in myocardial infarct patients].
  • Aranda JM Jr et al: Dobutamine-related asthma in a patient awaiting cardiac transplantation: the eosinophilic dilemma.
  • Riding WD et al: The bronchodilator and cardiac effects of five pressure-packed aerosols in asthma.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705479096.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. Cooper IF, Siadaty MS: 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; PharmacologicSubstanceAntibiotic;AsthmaCardiac:705491824. ISSN: 2331-5717. 2014/5/2
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  • [Title] 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Asthma Cardiac': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'pharmacologic substance or antibiotic or clinical drug' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'pharmacologic substance or antibiotic or clinical drug'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 25 publications, and group two 5620 publications.
  • Here are the top 10.
  • Vilsvik JS et al: Effect of atenolol on ventilatory and cardiac function in asthma.
  • Milner AD et al: Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
  • Martinez-Sabater H et al: Can adenosine cause asthma-like symptoms in patients with cardiac arrhythmias receiving atenolol?.
  • Al-Hillawi AH et al: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and slow release terbutaline for asthma.
  • Harrison P: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and terbutaline for asthma.
  • Mukharliamov NM et al: [Possibilities for using peripheral vasodilator agents in cardiac asthma and threatened pulmonary edema].
  • Takatsu T et al: [Management of congestive heart failure (2). Diuretic administration and vasodilator therapy of cardiac asthma and pulmonary edema (cardiac load reduction) with special reference to SQ 14225 (captopril)].
  • Martelli NA et al: Asthma, cardiac arrhythmias, and albuterol aerosol.
  • Meluzín J et al: [Cardiac asthma after nifedipine and diltiazem].
  • Wilcox PG et al: Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705491824.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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19. Yagishita-Tagawa Y, Yumino D, Takagi A, Serizawa N, Hagiwara N: Association between sleep apnea and overnight hemodynamic changes in hospitalized heart failure patients with and without paroxysmal nocturnal dyspnea. J Cardiol; 2013 May;61(5):348-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between sleep apnea and overnight hemodynamic changes in hospitalized heart failure patients with and without paroxysmal nocturnal dyspnea.
  • BACKGROUND: Paroxysmal nocturnal dyspnea (PND) is a common symptom for patients with acute decompensated heart failure (ADHF).
  • Some symptoms of PND are similar to those of sleep apnea (SA) which might be associated with overnight worsening hemodynamics in failing hearts.
  • However, the association between PND, SA, and overnight change in hemodynamics in patients with heart failure remains uncertain.
  • PND was defined as having an episode of PND prior to hospitalization for ADHF.
  • RESULTS: Ten (36%) patients had a history of PND.
  • Respiratory disturbance index (the frequency and severity of sleep apnea) was an independent factor associated with a history of PND (odds ratio 1.24, 95% confidence interval 1.05-1.47, p=0.011).
  • In those without PND, plasma ANP levels decreased from before sleep to after waking, whereas in those with PND it increased (p=0.011).
  • CONCLUSION: These results thus suggest that in patients with ADHF, SA might be a predisposing cause of PND in association with overnight worsening hemodynamics.
  • [MeSH-major] Atrial Natriuretic Factor / blood. Dyspnea, Paroxysmal / complications. Heart Failure / complications. Heart Failure / physiopathology. Sleep Apnea Syndromes / complications
  • [MeSH-minor] Acute Disease. Female. Hemodynamics / physiology. Hospitalization. Humans. Male. Middle Aged

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  • [Copyright] Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 23507270.001).
  • [ISSN] 1876-4738
  • [Journal-full-title] Journal of cardiology
  • [ISO-abbreviation] J Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 85637-73-6 / Atrial Natriuretic Factor
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20. Manzano L, Escobar C, Cleland JG, Flather M: Diagnosis of elderly patients with heart failure. Eur J Heart Fail; 2012 Oct;14(10):1097-103
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Particularly in the elderly, symptoms and signs of HF may be atypical and can be simulated or disguised by co-morbidities such as respiratory disease, obesity, and venous insufficiency.
  • The most useful clinical symptoms are orthopnoea and paroxysmal nocturnal dyspnoea.
  • Although natriuretic peptides accurately exclude cardiac dysfunction as a cause of symptoms, the optimal cut-off level for ruling out HF in elderly patients with other co-morbidities is still not clear.
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnosis, Differential. Dyspnea, Paroxysmal / diagnosis. Dyspnea, Paroxysmal / etiology. Echocardiography. Humans. Natriuretic Peptides / blood

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  • (PMID = 22771845.001).
  • [ISSN] 1879-0844
  • [Journal-full-title] European journal of heart failure
  • [ISO-abbreviation] Eur. J. Heart Fail.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Natriuretic Peptides
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21. Glancy DL, Atluri P, Heck H, Duet J, Ehsan K, Jaligam V, Helmcke F: ECG of the month. Cardiac failure and stroke in a 43-year-old woman. Coarse atrial fibrillation indicating left atrial enlargement and left ventricular hypertrophy with repolarization abnormality. J La State Med Soc; 2012 Nov-Dec;164(6):343-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] ECG of the month. Cardiac failure and stroke in a 43-year-old woman. Coarse atrial fibrillation indicating left atrial enlargement and left ventricular hypertrophy with repolarization abnormality.
  • A 43-year-old woman with a long history of heavy cigarette smoking was in good health until she developed fatigue, dyspnea on exertion, and paroxysmal nocturnal dyspnea approximately three months before admission to our hospital.
  • She was noted to be in atrial fibrillation, and cardiac catheterization and angiocardiography revealed triple-vessel coronary arterial disease and moderately severe mitral regurgitation.
  • Because of repeated episodes of paroxysmal nocturnal dyspnea, she was referred to our hospital for cardiac surgery.
  • [MeSH-minor] Adult. Cardiomegaly / complications. Dyspnea, Paroxysmal / complications. Female. Heart Failure / etiology. Humans. Hypertrophy, Left Ventricular / complications. Mitral Valve Insufficiency / complications. Stroke / etiology

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  • (PMID = 23437451.001).
  • [ISSN] 0024-6921
  • [Journal-full-title] The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
  • [ISO-abbreviation] J La State Med Soc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Mirdamadi SA, Arasteh M: Hiatal hernia: An unusual presentation of dyspnea. N Am J Med Sci; 2010 Aug;2(8):395-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hiatal hernia: An unusual presentation of dyspnea.
  • CONTEXT: Hiatal hernia is an infrequent but serious cause of dyspnea.
  • We report a case of acute dyspnea and paroxysmal nocturnal dyspnea secondary to hiatal hernia and epicardial fat pad.
  • CASE REPORT: A 78-year-old woman presented with dyspnea and paroxysmal nocturnal dyspnea.
  • CONCLUSION: Although rare, hiatal hernia should be suspected in patients who develop unexplained dyspnea.

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  • (PMID = 22737680.001).
  • [ISSN] 1947-2714
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3339066
  • [Keywords] NOTNLM ; Hiatal hernia / dyspnea
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23. Smithline HA, Caglar S, Blank FS: Assessing validity by comparing transition and static measures of dyspnea in patients with acute decompensated heart failure. Congest Heart Fail; 2010 Sep-Oct;16(5):202-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Assessing validity by comparing transition and static measures of dyspnea in patients with acute decompensated heart failure.
  • This study assessed the convergent validity of 2 dyspnea measures, the transition measure and the change measure, by comparing them with each other in patients admitted to the hospital with acute decompensated heart failure.
  • Static measures of dyspnea were obtained at baseline (pre-static measure) and at time 1 hour and 4 hour (post-static measures).
  • Both physicians and patients measured the dyspnea independently.
  • In general, short-term dyspnea assessment using transition measures and serial static measures can not be used to validate each other in this population of patients being admitted with acute decompensated heart failure.
  • [MeSH-major] Dyspnea, Paroxysmal. Heart Failure. Questionnaires / standards. Weights and Measures / instrumentation
  • [MeSH-minor] Aged. Aged, 80 and over. Diagnostic Self Evaluation. Disease Progression. Emergency Medical Services. Female. Humans. Male. Observation. Pain Measurement. Physicians. Reproducibility of Results. Self Report. Severity of Illness Index. Time Factors

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  • [Copyright] © 2010 Wiley Periodicals, Inc.
  • (PMID = 20887616.001).
  • [ISSN] 1751-7133
  • [Journal-full-title] Congestive heart failure (Greenwich, Conn.)
  • [ISO-abbreviation] Congest Heart Fail
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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24. Raja FS, Islam A, Khan M, Abbasi I: Type A aortic dissection presenting as superior vena cava syndrome. CJEM; 2013 Jan;15(1):59-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Type A aortic dissection presenting as superior vena cava syndrome.
  • A 51-year-old man presented with a 5-day history of progressive facial swelling, sensation of head fullness, increasing shortness of breath and paroxysmal nocturnal dyspnea.
  • Computed tomography scan of the thorax demonstrated a large type A aortic dissection almost completely effacing the SVC.
  • Acute type A aortic dissection (AD) is an emergency requiring prompt diagnosis and treatment.

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  • (PMID = 23283125.001).
  • [ISSN] 1481-8035
  • [Journal-full-title] CJEM
  • [ISO-abbreviation] CJEM
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Sewell GW, Marks DJ, Hasford C: Dyspnoeic dysphasia: a series of unfortunate events. Acute Med; 2011;10(4):203-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a case of a 56 year old man with no previous medical history who presented with sudden onset dyspnoea, expressive dysphasia, and right arm sensory loss and paresis.
  • [MeSH-major] Aphasia / etiology. Dyspnea, Paroxysmal / etiology. Foramen Ovale, Patent / complications. Pulmonary Embolism / complications

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  • (PMID = 22111100.001).
  • [ISSN] 1747-4892
  • [Journal-full-title] Acute medicine
  • [ISO-abbreviation] Acute Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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26. Bozdar M, Ahmed S, Jamy OH, Bin Hanif T, Ali N, Khan Khattak SA: Role of genetic counselling in prenatal diagnosis of β-thalassaemia in Pakistan. J Coll Physicians Surg Pak; 2013 Aug;23(8):553-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To compare the response towards prenatal diagnosis (PND) of b-thalassaemia, in individuals who had not received genetic counselling and a genetically counselled population.
  • METHODOLOGY: Using non-probability consecutive sampling, a total of 176 individuals having thalassaemic children, were interviewed regarding PND of thalassaemia, by using a structured questionnaire.
  • Forty two individuals were taken as controls as they had received genetic counselling for PND, whereas the remaining 134 were taken as cases.
  • Responses towards PND were compared using chi-square test.
  • Odds ratio was also calculated for subsequent PND utilization.
  • RESULTS: Seventy (52.2%) cases and 42 (100%) controls were aware of the availability of PND in Pakistan.
  • PND was used in subsequent pregnancies by 50 (37.3%) cases and 32 (80%) controls (p < 0.001).
  • The calculated odds ratio for subsequent PND utilization was 5.37.
  • CONCLUSION: The study reflects a very positive attitude of genetically counselled thalassaemia affected families towards PND.
  • For better utilization of PND, genetic counselling services should be available at all health strata.
  • [MeSH-minor] Case-Control Studies. Child. Cross-Sectional Studies. Female. Genetic Predisposition to Disease. Genetic Testing. Humans. Interviews as Topic. Male. Pakistan / epidemiology. Pregnancy. Questionnaires

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  • [ErratumIn] J Coll Physicians Surg Pak. 2014 Feb;24(2):149. Jamy, Omar [corrected to Jamy, Omer Hassan]
  • (PMID = 23930870.001).
  • [ISSN] 1681-7168
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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27. Tarantini G, Gasparetto V, Napodano M, Gerosa G, Isabella G: A case of combined percutaneous transfemoral mitral valvuloplasty and aortic valve implantation. J Invasive Cardiol; 2011 Aug;23(8):E200-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We present the case of an 83-year-old man who was admitted with New York Heart Association class III dyspnea and paroxysmal nocturnal dyspnea.
  • This case reports the feasibility of a totally percutaneous approach in combined rheumatic mitral and aortic valve disease for patients with prohibitive surgical risk.
  • [MeSH-major] Aortic Valve. Catheterization / methods. Heart Valve Diseases / therapy. Heart Valve Prosthesis. Mitral Valve. Prosthesis Implantation / methods. Rheumatic Heart Disease / therapy

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  • (PMID = 21828407.001).
  • [ISSN] 1557-2501
  • [Journal-full-title] The Journal of invasive cardiology
  • [ISO-abbreviation] J Invasive Cardiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Liu TD, Yu BY, Luo FH, Zhang XL, Wu SC, Liu LH, Wu YJ: Gene expression profiling of rat testis development during the early post-natal stages. Reprod Domest Anim; 2012 Oct;47(5):724-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we first examined the expression patterns of SYCP3, Tnp2, CDH1, glial cell-line-derived neurotropic factor (GDNF) and GFRA1 mRNAs on post-natal days (PNDs) 2, 4, 6, 8, 10, 12, 15, 20, 25 and 30 in rat testis.
  • SYCP3 mRNA was firstly detected from PND 15, while Tnp2 transcript was only found on PND 30.
  • CDH1 mRNA was highly expressed before PND 6, but decreased dramatically on PND 8, then gradually increased until it started to decrease after 12 dpp.
  • Low GDNF and GFRA1 mRNAs were found before PND 6, but gradually increased to the peak on PND 12, then gradually decreased to low level.
  • According to the expression patterns of CDH1, GDNF and GFRA1, we hypothesized that PNDs 6-10 are critical period in the early spermatogenesis.
  • We, therefore, explored gene expression pattern on PNDs 6, 8 and 10 using cDNA microarray.
  • 700 (PND 8 vs PND 6), 4519 (PND 10 vs PND 8), and 4298 (PND 10 vs PND 6) differentially expressed genes (≥ 2-fold) were identified from the comparisons, which cover thousands of gene ontology categories (GO terms) and hundreds of signalling pathways.

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  • [Copyright] © 2011 Blackwell Verlag GmbH.
  • (PMID = 22111653.001).
  • [ISSN] 1439-0531
  • [Journal-full-title] Reproduction in domestic animals = Zuchthygiene
  • [ISO-abbreviation] Reprod. Domest. Anim.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Gfra1 protein, rat; 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Glial Cell Line-Derived Neurotrophic Factor Receptors; 0 / RNA, Messenger
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29. Balci FL, Feldman SM: Interventional ductoscopy for pathological nipple discharge. Ann Surg Oncol; 2013 Oct;20(10):3352-4
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  • [Title] Interventional ductoscopy for pathological nipple discharge.
  • BACKGROUND: Despite the low likelihood of malignancy, it is recommended that patients who have pathologic nipple discharge (PND) undergo duct excision.
  • Intraductal papilloma is well-known most frequent cause of PND.
  • Our goal is to determine whether the ductoscopic retrieval of a solitary papilloma is feasible and/or therapeutic for patients with PND.
  • METHODS: Consented patients who had been diagnosed with PND were recruited to have ductoscopic exploration.
  • Success was determined by recurrence of PND and by standard radiological examinations.
  • These patients had no recurrence of discharge or suspicious of malignancy after 5 years follow-up.
  • CONCLUSIONS: Interventional ductoscopy provides an incisionless therapeutic option for patients diagnosed with a papillary nonsessile benign lesion that causes PND.

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  • (PMID = 23975311.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Flanigan TJ, Cook MN: Effects of an early handling-like procedure and individual housing on anxiety-like behavior in adult C57BL/6J and DBA/2J mice. PLoS One; 2011;6(4):e19058
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  • Evidence suggests that postnatal days (PND) 15-21 are a time of particular susceptibility to environmental influences on anxiety-like behavior in mice.
  • Pups were separated from dams from PND 12-20 for 30 minutes daily or received standard care.
  • On PND 21, pups were weaned and either individually- or group-housed.
  • On PND 60, anxiety-like behavior was examined on the elevated zero-maze.

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  • (PMID = 21533042.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3080884
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31. Mahmood Baig S, Sabih D, Rahim MK, Azhar A, Tariq M, Sajid Hussain M, Saqlan Naqvi SM, Raja GK, Khan TN, Jameel M, Iram Z, Noor S, Baig UR, Qureshi JA, Baig SA, Bakhtiar SM: β-Thalassemia in Pakistan: a pilot program on prenatal diagnosis in Multan. J Pediatr Hematol Oncol; 2012 Mar;34(2):90-2
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  • Prenatal diagnosis (PND) of β-thalassemia has been underutilized in Pakistan because of a number of social and economic factors.
  • National Institute for Biotechnology and Genetic Engineering Faisalabad in collaboration with Multan Institute of Nuclear Medicine and Radiotherapy Multan introduced free PND service for carrier couples of Multan district.
  • More than 170 couples registered for retrospective PND and in 2 years 105 PND were carried out through first trimester chorionic villus sampling.
  • Almost 90% of these couples were unable to afford the cost of PND and would not have undergone the test as free service was not available.
  • More families are registering for PND after establishment of this free and accessible PND service.


32. Stanley JA, Aruldhas MM, Yuvaraju PB, Banu SK, Anbalagan J, Neelamohan R, Annapoorna K, Jayaraman G: Is gender difference in postnatal thyroid growth associated with specific expression patterns of androgen and estrogen receptors? Steroids; 2010 Dec 12;75(13-14):1058-66
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  • [Title] Is gender difference in postnatal thyroid growth associated with specific expression patterns of androgen and estrogen receptors?
  • AR concentration remained elevated from postnatal day (PND) 10 onwards in males, whereas it decreased by PND 20 in females.
  • AR mRNA and protein expressions were higher in males than females, which increased by PND 10, decreased after PND 15 and reached the nadir by PND 20.
  • ER concentration increased by PND 10 and decreased thereafter in both sex.
  • ERα mRNA expression diminished by PND 15 in both sex; while ERβ mRNA decreased by PND 15 to reach the nadir by PND 20 in males, it was augmented by PND 10 in females to reach the peak by PND 15 and diminished by PND 20.
  • ERα protein expression increased by PND 10 and remained elevated till PND 20 in both sex.
  • ERβ protein expression in males increased by PND 10 and decreased by PND 20, while it remained static up to PND 15 and decreased in females.

  • HSDB. structure - ESTRADIOL.
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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20670640.001).
  • [ISSN] 1878-5867
  • [Journal-full-title] Steroids
  • [ISO-abbreviation] Steroids
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Androgens; 0 / Estrogens; 0 / RNA, Messenger; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Symporters; 0 / sodium-iodide symporter; 3XMK78S47O / Testosterone; 4TI98Z838E / Estradiol; 67763-96-6 / Insulin-Like Growth Factor I; VC2W18DGKR / Thymidine
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33. Collaço Rde C, Cogo JC, Rodrigues-Simioni L, Rocha T, Oshima-Franco Y, Randazzo-Moura P: Protection by Mikania laevigata (guaco) extract against the toxicity of Philodryas olfersii snake venom. Toxicon; 2012 Sep 15;60(4):614-22
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  • In this work, we examined the ability of an ethanolic extract from Mikania laevigata (guaco) leaves to protect against the in vitro neuromuscular activity of P. olfersii venom in mouse phrenic nerve-diaphragm (PND) and chick biventer cervicis (BC) preparations. M. laevigata extract caused moderate twitch-tension facilitation at low concentrations (107.4 ± 6.2% with 20 μl/ml and 118.9 ± 9.3% with 40 μl/ml in PND, and 120.7 ± 7.7% with 40 μl/ml and 114.5 ± 4.4% with 50 μl/ml in BC after 120 min; n = 4-6, mean ± SEM).
  • In PND, the ethanol alone (40 μl/ml, n = 4) did not change the twitch-tension when compared with control.
  • Venom (50 μg/ml) caused partial blockade in PND (58.5 ± 12%, n = 4) and almost total blockade in BC (93.5 ± 2.2%, n = 4).
  • Pretreatment of the preparations with extract (40 μl/ml) for 30 min before incubation with venom (50 μg/ml) completely protected PND from neuromuscular blockade and delayed the blockade in BC.
  • The extract alone caused only mild morphological alterations (12.5 ± 0.5% and 10.9 ± 2.3% fiber damage in PND and BC, respectively, compared to 2.3 ± 0.3% and 3 ± 0 in controls; n = 3), with no increase in expression of the inflammatory cytokines TNFα and IFNγ.
  • The ethanol alone also caused slight muscle damage: 4.3 ± 2.4% in PND and 6.7 ± 3.3% in BC (both n = 3) and little or no TNFα and IFNγ expression in both preparations as observed in control.
  • Venom (50 μg/ml) caused 53.5 ± 8.5% and 55.8 ± 4.3% fiber damage in PND and BC, respectively; (n = 3, p < 0.05 vs. controls) and enhanced expression of TNFα and IFNγ.
  • Pretreatment of the preparations with extract protected against venom-induced muscle damage by 80.3 and 60.4 in PND and BC, respectively, and prevented TNFα and IFNγ expression.
  • These results indicate that the M. laevigata extract protected nerve-muscle preparations against the myotoxic, neurotoxic and inflammatory effects of P. olfersii venom.
  • [MeSH-minor] Animals. Chickens. Colubridae / metabolism. Diaphragm / drug effects. Male. Mice. Muscle Contraction / drug effects. Muscle, Skeletal / drug effects. Muscle, Skeletal / pathology. Neuromuscular Blockade. Neuromuscular Junction / drug effects. Phrenic Nerve / drug effects

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  • [Copyright] Copyright © 2012 Elsevier Ltd. All rights reserved.
  • (PMID = 22677807.001).
  • [ISSN] 1879-3150
  • [Journal-full-title] Toxicon : official journal of the International Society on Toxinology
  • [ISO-abbreviation] Toxicon
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antidotes; 0 / Neuromuscular Blocking Agents; 0 / Neuroprotective Agents; 0 / Plant Extracts; 0 / Snake Venoms
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34. Paluch LR, Lieggi CC, Dumont M, Monette S, Riedel ER, Lipman NS: Developmental and behavioral effects of toe clipping on neonatal and preweanling mice with and without vapocoolant anesthesia. J Am Assoc Lab Anim Sci; 2014 Mar;53(2):132-40
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  • The few pertinent studies available evaluated mice between postnatal days (PND) 3 and 7, advocate the use of toe clipping in mice PND 7 or younger, and identify handling as the most distressing aspect of the procedure.
  • We also examined reflex development until PND 21 and adult behavior at 8 to 10 wk of age in mice toe clipped at PND 7 or 17 and the benefits of using topical vapocoolant anesthesia.
  • C57BL/6J pups at PND 7 and 17 were assigned to 1 of 4 groups:.
  • We conclude that the use of vapocoolant cannot be recommended due to its harmful effects and that toe clipping at PND 7 or 17 does not significantly affect the long-term welfare of mice.

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35. Lee TT, Hill MN, Hillard CJ, Gorzalka BB: Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. Synapse; 2013 Jan;67(1):4-10
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  • Brain tissue of male Sprague-Dawley rats was collected on postnatal days (PND) 25, 35, 45, and 70, representing pre-adolescence, early- to mid-adolescence, late adolescence, and adulthood, respectively.
  • NAE concentrations were lowest at PND 25 and highest at PND 35.
  • NAE concentrations decreased between PNDs 35 and 45 and increased between PNDs 45 and 70.
  • FAAH activity mirrored the pattern of NAE content in which it decreased between PNDs 25 and 35, increased between PNDs 35 and 45, and decreased between PNDs 45 and 70.

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
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  • (PMID = 22987804.001).
  • [ISSN] 1098-2396
  • [Journal-full-title] Synapse (New York, N.Y.)
  • [ISO-abbreviation] Synapse
  • [Language] eng
  • [Grant] United States / NIDA NIH HHS / DA / DA026996; United States / NIDA NIH HHS / DA / DA09155; United States / NIDA NIH HHS / DA / R01 DA009155; United States / NIDA NIH HHS / DA / R01 DA026996; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arachidonic Acids; 0 / Endocannabinoids; 0 / Ethanolamines; 0 / N-acylethanolamines; 0 / Polyunsaturated Alkamides; 94421-68-8 / anandamide; EC 3.5.- / Amidohydrolases; EC 3.5.1.- / fatty-acid amide hydrolase
  • [Other-IDs] NLM/ NIHMS407441; NLM/ PMC3510355
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36. Cavalcante WL, Hernandez-Oliveira S, Galbiatti C, Randazzo-Moura P, Rocha T, Ponce-Soto L, Marangoni S, Pai-Silva MD, Gallacci M, da Cruz-Höfling MA, Rodrigues-Simioni L: Biological characterization of Bothrops marajoensis snake venom. J Venom Res; 2011;2:37-41
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  • This study describes the effects of Bothrops marajoensis venom (Marajó lancehead) on isolated neuromuscular preparations of chick biventer cervicis (CBC) and mouse phrenic nerve-diaphragm (PND).
  • At low concentrations (1µg/ml for CBC and 5µg/ml for PND), the venom exhibited a neuromuscular blocking without any damaging effect on the muscle integrity.
  • At higher concentration (20μg/ml for PND), together with the neuromuscular blockade, there was a moderate myonecrosis.

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  • (PMID = 22091348.001).
  • [ISSN] 2044-0324
  • [Journal-full-title] Journal of venom research
  • [ISO-abbreviation] J Venom Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3211074
  • [Keywords] NOTNLM ; Marajó lancehead / myotoxicity / neuromuscular junction / neurotoxicity / presynaptic effects
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37. Inoue A, Arima A, Kato H, Yamashita N, Nishida Y, Ooshima Y, Ebihara S: Effects of maternal exposure to thiamazole on behavioral development in infant cynomolgus monkeys. Congenit Anom (Kyoto); 2013 Dec;53(4):149-54
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  • Swelling of the throat region due to enlargement of the thyroid glands was observed at birth in thiamazole-treated infants, and it returned to normal around postnatal day (PND) 30.
  • This finding suggested the likelihood that administration of thiamazole to maternal animals during the late gestational period induced thyroid goiter in fetal/infant monkeys through placental transfer of thiamazole.
  • Age-related changes were observed in the control in behavioral development tests, while infants at 3.5 mg/kg showed no age-related decrease in contact behavior and no increase in exploratory activity on PND 90 or PND 170.
  • In addition, the number of eye contacts between PND 210 and PND 240 was less frequent.

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  • [Copyright] © 2013 The Authors. Congenital Anomalies © 2013 Japanese Teratology Society.
  • (PMID = 24712473.001).
  • [ISSN] 1741-4520
  • [Journal-full-title] Congenital anomalies
  • [ISO-abbreviation] Congenit Anom (Kyoto)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antithyroid Agents; 06LU7C9H1V / Triiodothyronine; 554Z48XN5E / Methimazole; 9002-71-5 / Thyrotropin; Q51BO43MG4 / Thyroxine
  • [Keywords] NOTNLM ; behavioral development / cynomolgus monkey / infant / thiamazole / thyroid hormone
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38. Berná-Serna JD, Torres-Ales C, Berná-Mestre JD, Polo L: Role of galactography in the early diagnosis of breast cancer. Breast Care (Basel); 2013 May;8(2):122-6
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  • BACKGROUND: The purpose of this study was to evaluate the usefulness of galactography (GL) in the early diagnosis of breast cancer in patients with pathologic nipple discharge (PND).
  • PATIENTS AND METHODS: We retrospectively studied all galactograms obtained in 117 women with PND, who subsequently had a biopsy.
  • CONCLUSION: GL is a useful procedure in the early diagnosis of breast cancer in patients with PND.

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  • (PMID = 24419050.001).
  • [ISSN] 1661-3791
  • [Journal-full-title] Breast care (Basel, Switzerland)
  • [ISO-abbreviation] Breast Care (Basel)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3683945
  • [Keywords] NOTNLM ; GICS / Galactogram Imaging Classification System / Galactography / Histopathologic diagnosis / Pathologic nipple discharge
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39. Skirton H, Goldsmith L, Jackson L, Lewis C, Chitty L: Offering prenatal diagnostic tests: European guidelines for clinical practice [corrected]. Eur J Hum Genet; 2014 May;22(5):580-6
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  • However, there are no published guidelines for health professionals from varied disciplines who offer prenatal diagnosis (PND) in a range of possible settings including departments of maternity, obstetrics and clinical genetics.
  • Thirteen European health professionals, all experts in PND, participated in a workshop to develop the guidelines, which were then subjected to a wide consultation process.
  • The objective of PND was defined as providing prenatal diagnostic testing services (for genetic conditions) that enable families to make informed choices consistent with their individual needs and values and which support them in dealing with the outcome of such testing.

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  • (PMID = 24022298.001).
  • [ISSN] 1476-5438
  • [Journal-full-title] European journal of human genetics : EJHG
  • [ISO-abbreviation] Eur. J. Hum. Genet.
  • [Language] eng
  • [Grant] United Kingdom / Department of Health / / RP-PG-0707-10107
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3992567
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40. Clemens JM, Ritter NJ, Roy A, Miller JM, Van Hooser SD: The laminar development of direction selectivity in ferret visual cortex. J Neurosci; 2012 Dec 12;32(50):18177-85
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  • Layer 4 neurons in animals that had opened their eyes but were younger than postnatal day 35 (PND 35) exhibited modestly increased direction selectivity, but layer 2/3 cells remained as weakly tuned as before eye opening.
  • Animals that had opened their eyes and were PND 35 or older exhibited increased direction selectivity in both layers 4 and 2/3.
  • On average, initial increases in direction selectivity in animals younger than PND 35 were explained by increases in responses to the preferred direction, while subsequent increases in direction selectivity in animals PND 35 or older were explained by decreases in responses to the null direction.

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  • (PMID = 23238731.001).
  • [ISSN] 1529-2401
  • [Journal-full-title] The Journal of neuroscience : the official journal of the Society for Neuroscience
  • [ISO-abbreviation] J. Neurosci.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / P30 NS069339
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS428759; NLM/ PMC3532899
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41. Tonk EC, de Groot DM, Wolterbeek AP, Penninks AH, Waalkens-Berendsen ID, Piersma AH, van Loveren H: Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study. Arch Toxicol; 2013 Feb;87(2):323-35
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  • Immune assessments were performed at postnatal days (PNDs) 21, 42 and 70.
  • Keyhole limpet hemocyanin (KLH)-specific immune responses were evaluated following subcutaneous immunizations on PNDs 21 and 35.
  • However, effects on LPS-induced NO and TNF-α production by adherent splenocytes and KLH-specific parameters persisted until PND 70.

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  • (PMID = 23007559.001).
  • [ISSN] 1432-0738
  • [Journal-full-title] Archives of toxicology
  • [ISO-abbreviation] Arch. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Central Nervous System Depressants; 0 / Lipopolysaccharides; 0 / Tumor Necrosis Factor-alpha; 31C4KY9ESH / Nitric Oxide; 3K9958V90M / Ethanol; 9013-72-3 / Hemocyanin; FV4Y0JO2CX / keyhole-limpet hemocyanin
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42. Chen C, Tang Y, Jiang X, Qi Y, Cheng S, Qiu C, Peng B, Tu B: Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood. Toxicol Sci; 2012 Jan;125(1):248-61
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  • [Title] Early postnatal benzo(a)pyrene exposure in Sprague-Dawley rats causes persistent neurobehavioral impairments that emerge postnatally and continue into adolescence and adulthood.
  • The current study was conducted to determine whether neurotoxic effects of postnatal BaP exposure on behavioral performance persist in juvenile and young adult stages.
  • Therefore, neonate Sprague-Dawley pups were given oral doses of BaP (0.02, 0.2, and 2 mg/kg/day) continuing through a period of rapid brain development (on postnatal days [PNDs] 5-11).
  • Moreover, the locomotor activity deficit in BaP-treated pups was evident at PND 36 and was most pronounced in the PND 69.
  • Also, exposure to BaP during early postnatal development had an adverse effect on adult rats (PND 70) in the elevated plus maze, and the swim maze suggests that low doses of BaP impair spatial learning functions at adult test period.
  • These data clearly indicate that behavioral impairments resulting from postnatal BaP exposure are potentially long-lasting and may not be apparent in juveniles, but are present in young adulthood.

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  • (PMID = 21984485.001).
  • [ISSN] 1096-0929
  • [Journal-full-title] Toxicological sciences : an official journal of the Society of Toxicology
  • [ISO-abbreviation] Toxicol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 3417WMA06D / Benzo(a)pyrene
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43. Purcell RH, Sun B, Pass LL, Power ML, Moran TH, Tamashiro KL: Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior. Physiol Behav; 2011 Sep 1;104(3):474-9
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  • Chronic variable prenatal stress or maternal high-fat diet results in offspring that are significantly heavier by the end of the first postnatal week with increased adiposity by weaning.
  • We found that dams maintained on a HF diet through gestation and lactation spent significantly more time nursing their pups during the first postnatal week.
  • In addition, offspring of prenatal stress dams consumed more milk at postnatal day (PND) 3 and offspring of HF dams consume more milk on PND 7 in an independent ingestion test.
  • Milk from HF dams showed a significant increase in fat content from PND 10-21.
  • Together these results suggest that gestational dietary or stress manipulations can alter the rat offspring's developmental environment, evidence of which is apparent by PND 3.
  • Alterations in maternal care, milk composition, and pup consumption during the early postnatal period may contribute to long-term changes in body weight and adiposity induced by maternal prenatal stress or high-fat diet.

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
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  • (PMID = 21605577.001).
  • [ISSN] 1873-507X
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / DK077623; United States / NICHD NIH HHS / HD / HD055030; United States / NICHD NIH HHS / HD / K99 HD055030; United States / NICHD NIH HHS / HD / K99 HD055030-02; United States / NICHD NIH HHS / HD / R00 HD055030; United States / NICHD NIH HHS / HD / R00 HD055030-05; United States / NIDDK NIH HHS / DK / R01 DK077623; United States / NIDDK NIH HHS / DK / R01 DK077623-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dietary Fats
  • [Other-IDs] NLM/ NIHMS296697; NLM/ PMC3142767
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44. Vanisthasree K, Reddy AG, Kalakumar B, Haritha C, Anilkumar B: Hepatotoxicity studies in the progeny of pregnant dams treated with methimazole, monocrotophos and lead acetate. Toxicol Int; 2011 Jan;18(1):67-9
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  • Female pregnant albino rats of Wistar kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning of pups on postnatal day (PND) 21.
  • Eight pups from each group were euthanized on PND 21 and 90, and liver tissues were collected for analysis.
  • Thiobarbituric acid reactive substances (TBARS), protein carbonyls and reduced glutathione (GSH) of liver were studied on PND 21 and 90, while the activities of Na (+)/K(+)ATPase and Mg (2+)ATPase in the liver were studied on PND 90.

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  • (PMID = 21430926.001).
  • [ISSN] 0976-5131
  • [Journal-full-title] Toxicology international
  • [ISO-abbreviation] Toxicol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3052590
  • [Keywords] NOTNLM ; Hepatotoxicity / lead acetate / methimazole / monocrotophos / rats
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45. Dai XM, Guo XH, An XF, Liu HR, Zhang B: [Effects of soy isoflavone on the reproductive system development and ER-beta expression in male rat offspring in different postnatal periods]. Zhonghua Nan Ke Xue; 2012 Oct;18(10):915-9
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  • [Title] [Effects of soy isoflavone on the reproductive system development and ER-beta expression in male rat offspring in different postnatal periods].
  • On postnatal day (PND) 21, the male offspring were treated in the same manner till sexual maturity, and on PND 49 and 90, 6 male rats from each group were killed for observation of the related indicators of the reproductive system development and the detection of the expression of ER-beta in the testis.
  • RESULTS: The mean daily food intake showed no evident differences among the SIF and DES groups, but the food efficiency ratio (FER) was significantly decreased in the 200 and 400 mg/kg SIF and 0.1 mg/kg DES groups (P < 0.05) at 49 and 90 PND.
  • At the dose of > or = 50 mg/kg, SIF markedly reduced the body weight of the rats (P < 0.05), even more so at 90 PND than at 49 PND.
  • The increased dose of SIF was correlated with the reduction of testis weight, sperm head count and daily sperm production, and so was it with the elevation of the ER-beta expression, both more obviously at 90 PND than at 49 PND.

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  • (PMID = 23297501.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Estrogen Receptor beta; 0 / Isoflavones
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46. Betharia S, Maher TJ: Neurobehavioral effects of lead and manganese individually and in combination in developmentally exposed rats. Neurotoxicology; 2012 Oct;33(5):1117-27
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  • Mixture-exposed pups exhibited the fastest righting times when tested between postnatal days (PNDs) 1 and 10.
  • Learning and memory were assessed in five-day Morris water maze (MWM) tests, ending in probe trials on PNDs 25 and 60.
  • On PND 24, mixture-exposed males performed significantly better than individual metal-exposed males, but this effect was no longer evident between PNDs 56 and 60.
  • In the open-field test, Mn-exposed males were hypoactive and displayed greater anxiety than controls on PND 24, and showed similar trends when the test was repeated on PND 59.

  • HSDB. structure - LEAD, ELEMENTAL.
  • HSDB. structure - MANGANESE, ELEMENTAL.
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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22732189.001).
  • [ISSN] 1872-9711
  • [Journal-full-title] Neurotoxicology
  • [ISO-abbreviation] Neurotoxicology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Drug Combinations; 2P299V784P / Lead; 42Z2K6ZL8P / Manganese
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47. Macrini TE: Development of the ethmoid in Caluromys philander (Didelphidae, Marsupialia) with a discussion on the homology of the turbinal elements in marsupials. Anat Rec (Hoboken); 2014 Nov;297(11):2007-17
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  • In this study, the development of the ethmoid of Caluromys philander, the bare-tailed woolly opossum, is described based on serial sections of six pouchlings ranging in age from 20 to 84 days postnatal (PND-84), and computed tomography images of an adult skull.
  • I found that four ethmoturbinals initially develop as seen in PND-20 and PND-30 individuals but by PND-64 an interturbinal (corresponding to endoturbinal III in adults) is present between ethmoturbinals II and III.

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  • [Copyright] © 2014 Wiley Periodicals, Inc.
  • (PMID = 25312361.001).
  • [ISSN] 1932-8494
  • [Journal-full-title] Anatomical record (Hoboken, N.J. : 2007)
  • [ISO-abbreviation] Anat Rec (Hoboken)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Mammalia / ethmoid / skull development / turbinal / turbinate
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48. Zavitsanou K, Dalton VS, Walker AK, Weickert CS, Sominsky L, Hodgson DM: Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse; 2013 Jun;67(6):290-9
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  • Rats were treated with the bacterial endotoxin lipopolysaccharide (LPS) on postnatal day (PND) 3 and 5.
  • Dopamine D1, D2, serotonin 5HT1A, 5HT2A, and serotonin transporter and cannabinoid CB1 receptor binding across several brain regions were measured autoradiographically in adulthood (PND 85).

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  • [Copyright] Copyright © 2013 Wiley Periodicals, Inc.
  • (PMID = 23389966.001).
  • [ISSN] 1098-2396
  • [Journal-full-title] Synapse (New York, N.Y.)
  • [ISO-abbreviation] Synapse
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Lipopolysaccharides; 0 / Receptor, Cannabinoid, CB1; 0 / Receptors, Dopamine; 0 / Receptors, Serotonin; 0 / Serotonin Plasma Membrane Transport Proteins
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49. Llorente-Berzal A, Puighermanal E, Burokas A, Ozaita A, Maldonado R, Marco EM, Viveros MP: Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption. PLoS One; 2013;8(11):e78386
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  • ] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two daily doses of 10 mg/kg every 5 days; s.c.
  • ] from pnd 30 to 45, in both male and female Wistar rats.
  • When tested one day after the end of the pharmacological treatment (pnd 46), MDMA administration induced a reduction in directed exploration in the holeboard test and an increase in open-arm exploration in an elevated plus maze.
  • [MeSH-minor] Adolescent. Animals. Cerebral Cortex / drug effects. Cerebral Cortex / metabolism. Cerebral Cortex / physiopathology. Cytoskeletal Proteins / genetics. Cytoskeletal Proteins / metabolism. Exploratory Behavior / drug effects. Female. Gene Expression / drug effects. Hippocampus / drug effects. Hippocampus / metabolism. Hippocampus / physiopathology. Humans. Hypothalamus / drug effects. Hypothalamus / metabolism. Hypothalamus / physiopathology. Intracellular Signaling Peptides and Proteins / genetics. Intracellular Signaling Peptides and Proteins / metabolism. Male. Maze Learning / drug effects. Mitogen-Activated Protein Kinase 1 / genetics. Mitogen-Activated Protein Kinase 1 / metabolism. Mitogen-Activated Protein Kinase 3 / genetics. Mitogen-Activated Protein Kinase 3 / metabolism. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Neuropeptides / genetics. Neuropeptides / metabolism. Rats. Rats, Wistar. Sex Factors

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  • [ErratumIn] PLoS One. 2013;8(12). doi:10.1371/annotation/89e38eb6-e8e3-402d-a6fb-84ebf9fcbb27
  • (PMID = 24223797.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / Hallucinogens; 0 / Intracellular Signaling Peptides and Proteins; 0 / Nerve Tissue Proteins; 0 / Neuropeptides; 0 / activity regulated cytoskeletal-associated protein; 0 / orexins; 7J8897W37S / Dronabinol; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 1; EC 2.7.11.24 / Mitogen-Activated Protein Kinase 3; KE1SEN21RM / N-Methyl-3,4-methylenedioxyamphetamine
  • [Other-IDs] NLM/ PMC3817254
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50. Otten W, Kanitz E, Tuchscherer M, Gräbner M, Nürnberg G, Bellmann O, Hennig U, Rehfeldt C, Metges CC: Effects of low and high protein:carbohydrate ratios in the diet of pregnant gilts on maternal cortisol concentrations and the adrenocortical and sympathoadrenal reactivity in their offspring. J Anim Sci; 2013 Jun;91(6):2680-92
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  • The offspring were cross-fostered, and the plasma cortisol and catecholamine concentrations of the offspring were determined on postnatal d (PND) 1 and 27 and under specific challenging conditions: after weaning (PND 29) and after ACTH and insulin challenges (PND 68 and 70, respectively).
  • No differences between diets were found for cortisol, corticosteroid-binding globulin, and catecholamine concentrations in plasma and for GR binding in hippocampus and hypothalamus in piglets at PND 1 and 27.
  • On PND 81, an increased adrenal medulla area was observed in LP offspring compared with the AP offspring (P < 0.05).


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