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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 54%  Chen S, Levin RA, Gartner JA: Medication adherence and enrollment in a consumer-driven health plan. Am J Manag Care; 2010 Feb;16(2):e43-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: Consumer-driven health plan patients were enrolled in a traditional managed care plan in 2005 (pre-year) and a full-replacement CDHP in 2006 (post-year).
  • The continuation rate was relatively high for all drug classes, although the CDHP cohort had a lower probability of continuing cardiac and cholesterol drugs.
  • Consumer-driven health plan patients took slightly longer on average to refill their first prescription in the post-year for cardiac, hypertension, cholesterol, and thyroid drugs.
  • The compliance rate dropped over time in both cohorts, but the reduction was bigger among CDHP patients for 3 drug classes (adjusted ratio of the odds ratios was 0.77, 0.78, and 0.69 for asthma, cardiac, and cholesterol drugs, respectively).

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  • (PMID = 20148609.001).
  • [ISSN] 1936-2692
  • [Journal-full-title] The American journal of managed care
  • [ISO-abbreviation] Am J Manag Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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2. |||||..... 47%  Sears MR, Ottosson A, Radner F, Suissa S: Long-acting beta-agonists: a review of formoterol safety data from asthma clinical trials. Eur Respir J; 2009 Jan;33(1):21-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-acting beta-agonists: a review of formoterol safety data from asthma clinical trials.
  • The safety of long-acting beta(2)-agonist (LABA) treatment in asthma has been questioned following reported increased respiratory deaths when salmeterol was added to usual pharmacotherapy.
  • The aim of this study was to examine whether asthma, cardiac or all-cause mortality and morbidity were increased with formoterol use.
  • The analysis included all AstraZeneca randomised controlled parallel-group asthma trials of 3-12-months duration involving formoterol.
  • Risks associated with formoterol use compared with non-LABA treatment, overall and in combination with inhaled corticosteroids (ICS), were assessed using an intention-to-treat analysis of the rates and rate ratios of deaths and serious adverse events (SAEs).
  • The main objective of this study was to compare asthma-related mortality in patients using formoterol and those not using formoterol.
  • There were eight asthma-related deaths (0.34 per 1,000 person-yrs) among 49,906 formoterol-randomised patients (92% using ICS), and two (0.22 per 1,000 person-yrs) among 18,098 patients (83% using ICS) not randomised to formoterol, which was nonsignificant.
  • Asthma-related SAEs (>90% of which were hospitalisations) were significantly fewer among formoterol-randomised patients (0.75 versus 1.10%).
  • There was no increase in asthma-related SAEs with increased daily doses of formoterol (9, 18 or 36 microg).
  • There was no significant difference in cardiac mortality or noncardiac nonasthma-related mortality in formoterol-randomised compared to non-LABA-treated patients.
  • In the data set in which all subjects were prescribed ICS at baseline, there were seven asthma-related deaths (0.32 per 1,000 person-yrs) among 46,003 formoterol-randomised patients and one (0.14 per 1,000 person-yrs) among 13,905 patients not randomised to formoterol, which was also nonsignificant.
  • There were few asthma-related or cardiac-related deaths among patients randomised to formoterol, and all differences were nonsignificant compared with non-long-acting beta(2)-agonist-randomised patients.
  • Cardiac-related serious adverse events were not increased, and asthma-related serious adverse events were significantly reduced with formoterol.
  • [MeSH-major] Adrenergic beta-Agonists / adverse effects. Asthma / drug therapy. Asthma / mortality. Ethanolamines / adverse effects

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  • [CommentIn] Eur Respir J. 2009 Jan;33(1):3-5 [19118222.001]
  • (PMID = 18768573.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Adrenergic beta-Agonists; 0 / Ethanolamines; 0 / Glucocorticoids; 5ZZ84GCW8B / formoterol
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3. |......... 3%  Sertogullarindan B, Ozbay B, Gumrukcuoglu HA, Akil MA, Bilgin MH, Yasar M: A case of viral myocarditis presenting with acute asthma attack. J Clin Med Res; 2012 Jun;4(3):224-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of viral myocarditis presenting with acute asthma attack.
  • Cardiac asthma is commonly observed in elderly patients with left heart failure.
  • We report a young case of viral myocarditis mimicking acute asthma attack.
  • CASE PRESENTATION: A 27-year-old young man with a history of asthma presented to the pulmonary department of our hospital with dyspnea, left sided chest pain, cough, wheezing.
  • Asthma was diagnosed and treated, however his respiratory complaints have persisted.
  • Laboratory evaluations revealed that elevated cardiac enzymes, Echocardiogram showed global hypokinesia in the left ventricle and a decrease of ejection fraction.
  • We concluded that viral myocarditis can present itself like an acute asthma attack.

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  • (PMID = 22719812.001).
  • [ISSN] 1918-3011
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3376884
  • [Keywords] NOTNLM ; Asthma / Diagnosis / Myocarditis
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4. |......... 2%  Ramakrishna CD, Khadar SA, George R, Jayaprakash VL, Sudhayakumar N, Jayaprakash K, Pappachan JM: The age-specific clinical and anatomical profile of mitral stenosis. Singapore Med J; 2009 Jul;50(7):680-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The mean duration of exertional dyspnoea, history of paroxysmal nocturnal dyspnoea, mean NYHA class, mean left atrial sizes, mean mitral valve areas and mean mitral valve gradients did not vary significantly among the three groups.

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  • (PMID = 19644622.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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5. |......... 2%  Effing T: Action plans and case manager support may hasten recovery of symptoms following an acute exacerbation in patients with chronic obstructive pulmonary disease (COPD). J Physiother; 2012;58(1):60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Action plans and case manager support may hasten recovery of symptoms following an acute exacerbation in patients with chronic obstructive pulmonary disease (COPD).
  • Exclusion criteria were a primary diagnosis of asthma or cardiac disease, or presence of disease that would affect mortality or participation (eg, confusion).
  • INTERVENTIONS: Both groups received usual care and brief nurse-led education about management of their disease.

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  • [Copyright] Copyright © 2012 Australian Physiotherapy Association. Published by .. All rights reserved.
  • [CommentOn] Thorax. 2011 Nov;66(11):977-84 [21785156.001]
  • (PMID = 22341386.001).
  • [ISSN] 1836-9553
  • [Journal-full-title] Journal of physiotherapy
  • [ISO-abbreviation] J Physiother
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] Australia
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6. |......... 2%  Coman L, Coman OA, Păunescu H, Drăghia F, Fulga I: VEGF-induced corneal neovascularisation in a rabbit experimental model. Rom J Morphol Embryol; 2010;51(2):327-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] VEGF-induced corneal neovascularisation in a rabbit experimental model.
  • The aim of the present study was to create a reproducible experimental model that could enable the investigation of the phenomena leading to corneal vascularization.
  • Central and peripheral corneal burns were induced to other groups of animals in order to mimic the neovascularization process induced by inflammation.
  • Finally, Dexamethasone (Maxidex) was given intraocularly, on days 1 and 3 after the onset of neovascularisation, in rabbit groups with both corneal burns and VEGF-implants.
  • Video recording and data analysis of the corneal vascularization were made with an advanced biomicroscope, a computerized imaging system and a special software.
  • The results showed the importance of VEGF as an initiator and promoter of corneal vascularization through a non-inflammatory mechanism, quite different from the inflammation illustrated by the corneal burn.
  • At the same time, Dexamethasone therapy proved its effectiveness in corneal angiogenesis induced by thermal burn, but not by VEGF-implant.
  • [MeSH-major] Corneal Neovascularization / drug therapy. Vascular Endothelial Growth Factor A / pharmacology
  • [MeSH-minor] Animals. Eye Burns / physiopathology. Female. Male. Models, Animal. Rabbits

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  • (PMID = 20495752.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor A
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7. |......... 3%  Ceridon M, Wanner A, Johnson BD: Does the bronchial circulation contribute to congestion in heart failure? Med Hypotheses; 2009 Sep;73(3):414-9
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  • Congestion may occur in the bronchial circulation from either a marked increase in flow or an increase in blood volume but with a reduction in flow due to high cardiac filling pressures and high pulmonary vascular pressures (a stasis like condition).
  • Either may lead to thickened bronchial mucosal and submucosal tissues and reduced airway compliance resulting in airway obstruction and restriction and a lack of airway distensibility.
  • These structural changes may contribute to "cardiac asthma" and dyspnea, characteristic features common in HF patients.
  • We ultimately hypothesize that the engorgement of the bronchial circulatory bed may play a role in pulmonary function abnormalities that occur in HF patients and contribute to symptoms such as orthopnea and exertional dyspnea.

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  • (PMID = 19464810.001).
  • [ISSN] 1532-2777
  • [Journal-full-title] Medical hypotheses
  • [ISO-abbreviation] Med. Hypotheses
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL071478; United States / NHLBI NIH HHS / HL / R01 HL071478-05
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS135190; NLM/ PMC2738626
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8. |||||||||. 1444%  Cooper IF, Siadaty MS: 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; OrganicChemical;AsthmaCardiac:705786856. ISSN: 2331-5717. 2014/5/28
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  • [Title] 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications.
  • Background: There are articles published each month which present 'Organic Chemical' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Cooper IF et al: 'Organic Chemicals' associated with 'Asthma Cardiac': Top Publications.
  • Vilsvik JS et al: Effect of atenolol on ventilatory and cardiac function in asthma.
  • Milner AD et al: Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
  • Martinez-Sabater H et al: Can adenosine cause asthma-like symptoms in patients with cardiac arrhythmias receiving atenolol?.
  • Al-Hillawi AH et al: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and slow release terbutaline for asthma.
  • Harrison P: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and terbutaline for asthma.
  • HILDEN T: The effect of tetraethylammonium bromide (etylon) on cardiac asthma and acute pulmonary oedema.
  • Martelli NA et al: Asthma, cardiac arrhythmias, and albuterol aerosol.
  • Wilcox PG et al: Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma.
  • Meluzín J et al: [Cardiac asthma after nifedipine and diltiazem].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705786856.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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9. |||||||||. 1423%  Cooper IF, Siadaty MS: 'Steroids' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; Steroid;AsthmaCardiac:705938032. ISSN: 2331-5717. 2014/5/7
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  • [Title] 'Steroids' associated with 'Asthma Cardiac': Top Publications.
  • Background: There are articles published each month which present 'steroid' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Rosero SZ et al: Asthma and the risk of cardiac events in the Long QT syndrome. Long QT Syndrome Investigative Group.
  • Jarcho S: Rostan on asthma in the aged (cardiac asthma), 1818.
  • Zecevic D et al: [Effects of the new brondilatator reproterol on the cardiac function during treatment of bronchial asthma and chronic obstructive bronchitis (author's transl)].
  • TOMOMATSU T: [SYMPOSIUM ON CIRCULATORY DISORDERS OF THE LUNG. (5). CARDIAC ASTHMA].
  • Tanabe T et al: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Spreng P et al: [Siderophages in the sputum: contribution to the differential diagnosis of cardiac asthma and bronchial asthma].
  • MLCZOCH F: [BRONCHIAL ASTHMA AND CARDIAC ASTHMA--AN OLD SUBJECT IN THE LIGHT OF NEW DATA].
  • Stupnitskiĭ AA: [Heart activity in patients with cardiac asthma on the basis of phonocardiographic data].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705938032.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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10. ||||||.... 61%  Schulz H, Dale GE, Karimi-Nejad Y, Oefner C: Structure of human endothelin-converting enzyme I complexed with phosphoramidon. J Mol Biol; 2009 Jan 9;385(1):178-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Endothelin-1 overproduction has been implicated in a heterogeneous list of diseases including systemic and pulmonary hypertension, stroke and asthma, cardiac and renal failure.
  • Here, we present the crystal structure of the extracellular domain (residues 90-770) of human ECE-1 (C428S) with the generic metalloprotease inhibitor phosphoramidon determined at 2.38 A resolution.
  • The structure is closely related to that of human NEP, providing essential information for a detailed understanding of ligand-binding, specificity determinants as well as selectivity criteria.
  • [MeSH-minor] Amino Acid Sequence. Catalytic Domain. Crystallography, X-Ray. Enzyme Inhibitors / metabolism. Enzyme Inhibitors / pharmacology. Humans. Hydrogen Bonding / drug effects. Models, Molecular. Molecular Sequence Data. Neprilysin / chemistry. Protein Structure, Secondary. Sequence Alignment. Substrate Specificity / drug effects. Surface Properties / drug effects. Zinc / metabolism

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  • (PMID = 18992253.001).
  • [ISSN] 1089-8638
  • [Journal-full-title] Journal of molecular biology
  • [ISO-abbreviation] J. Mol. Biol.
  • [Language] eng
  • [Databank-accession-numbers] PDB/ 3DWB
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Glycopeptides; 36357-77-4 / phosphoramidon; EC 3.4.23.- / Aspartic Acid Endopeptidases; EC 3.4.24.- / Metalloendopeptidases; EC 3.4.24.11 / Neprilysin; EC 3.4.24.71 / endothelin-converting enzyme; J41CSQ7QDS / Zinc
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11. ||||||.... 61%  Selvi RB, Kundu TK: Reversible acetylation of chromatin: implication in regulation of gene expression, disease and therapeutics. Biotechnol J; 2009 Mar;4(3):375-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Reversible acetylation of chromatin: implication in regulation of gene expression, disease and therapeutics.
  • Dysfunction of the HATs/HDACs is associated with various diseases like cancer, diabetes, asthma, cardiac hypertrophy, retroviral pathogenesis and neurodegenerative disorders.
  • Although substantial progress has been made in the area of HDAC inhibitors, we have focused this review on the HATs and their small-molecule modulators in the context of disease and therapeutics.
  • [MeSH-minor] Animals. Asthma / metabolism. Diabetes Mellitus / metabolism. Enzyme Inhibitors / therapeutic use. Heart Diseases / metabolism. Histones / chemistry. Humans. Malaria / metabolism. Neoplasms / metabolism. Neurodegenerative Diseases / therapy. Protein Processing, Post-Translational. Virus Diseases / metabolism

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  • (PMID = 19296442.001).
  • [ISSN] 1860-7314
  • [Journal-full-title] Biotechnology journal
  • [ISO-abbreviation] Biotechnol J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Chromatin; 0 / Enzyme Inhibitors; 0 / Histones
  • [Number-of-references] 58
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12. |......... 7%  Tanabe T, Rozycki HJ, Kanoh S, Rubin BK: Cardiac asthma: new insights into an old disease. Expert Rev Respir Med; 2012 Dec;6(6):705-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma: new insights into an old disease.
  • Cardiac asthma has been defined as wheezing, coughing and orthopnea due to congestive heart failure.
  • The clinical distinction between bronchial asthma and cardiac asthma can be straight forward, except in patients with chronic lung disease coexisting with left heart disease.
  • Pulmonary edema and pulmonary vascular congestion have been thought to be the primary causes of cardiac asthma but most patients have a poor response to diuretics.
  • There appears to be limited effectiveness of classical asthma medications like bronchodilators or corticosteroids in treating cardiac asthma.
  • [MeSH-major] Cough / physiopathology. Dyspnea / physiopathology. Heart Failure / physiopathology. Respiratory Sounds / physiopathology

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  • (PMID = 23234454.001).
  • [ISSN] 1747-6356
  • [Journal-full-title] Expert review of respiratory medicine
  • [ISO-abbreviation] Expert Rev Respir Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Adrenergic beta-2 Receptor Agonists; 0 / Angiotensin Receptor Antagonists; 0 / Angiotensin-Converting Enzyme Inhibitors; 0 / Antibodies, Monoclonal, Humanized; 0 / Bronchodilator Agents; 0 / Diuretics; GR88G0I6UL / Ipratropium
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13. |......... 5%  Tanabe T, Kanoh S, Moskowitz WB, Rubin BK: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung. Chest; 2012 Nov;142(5):1274-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • BACKGROUND: Cardiac asthma describes symptoms of airflow obstruction due to heart failure.
  • Fibrotic remodeling of the heart and airways is mediated, in part, through transforming growth factor (TGF)- β .
  • Blood TGF- b 1 concentration correlates with ventricular remodeling in cardiac disease, and TGF- β decreases after repair.
  • Phosphorylation of Smad in NHBE cells was determined by Western blotting.Mice given doxorubicin developed cardiac failure, and their airways were histologically examined.
  • CONCLUSIONS: TGF- β from cardiomyoblasts or from the failing heart can cause airway squamous metaplasia via Smad signaling, and this is blocked by anti-TGF- b antibody and reversed when cardiac cells are removed from culture.
  • This appears to be an important mechanism for airflow obstruction with heart failure, sometimes described as cardiac asthma.
  • [MeSH-minor] Analysis of Variance. Animals. Blotting, Western. Bronchi / cytology. Coculture Techniques. DNA Primers. Doxorubicin. Enzyme-Linked Immunosorbent Assay. Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism. Humans. Immunohistochemistry. Male. Mice. Mice, Inbred C57BL. Myocytes, Cardiac / metabolism. Phosphorylation. Protein Precursors / metabolism. Rats. Real-Time Polymerase Chain Reaction. Signal Transduction. Smad Proteins / metabolism

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  • (PMID = 22505689.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA Primers; 0 / Protein Precursors; 0 / Smad Proteins; 0 / Transforming Growth Factor beta; 60108-77-2 / involucrin; 80168379AG / Doxorubicin; EC 1.2.1.9 / Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
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14. |......... 3%  Buckner K: Cardiac asthma. Immunol Allergy Clin North Am; 2013 Feb;33(1):35-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiac asthma.
  • Cardiac dyspnea, especially if present only with exercise, is often confused with asthma and exercise-induced bronchospasm.
  • Cardiac dyspnea or asthma is the consequence of pulmonary edema due to pulmonary venous hypertension and not due to asthmatic bronchoconstriction.
  • [MeSH-major] Asthma / diagnosis. Dyspnea / diagnosis. Dyspnea / etiology. Heart Failure / complications


15. |||||||||. 1423%  Cooper IF, Siadaty MS: 'Hormones' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; Hormone;AsthmaCardiac:705919996. ISSN: 2331-5717. 2014/6/6
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  • [Title] 'Hormones' associated with 'Asthma Cardiac': Top Publications.
  • Background: There are articles published each month which present 'Hormone' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Cooper IF et al: 'Hormones' associated with 'Asthma Cardiac': Top Publications.
  • Rosero SZ et al: Asthma and the risk of cardiac events in the Long QT syndrome. Long QT Syndrome Investigative Group.
  • Jarcho S: Rostan on asthma in the aged (cardiac asthma), 1818.
  • Zecevic D et al: [Effects of the new brondilatator reproterol on the cardiac function during treatment of bronchial asthma and chronic obstructive bronchitis (author's transl)].
  • TOMOMATSU T: [SYMPOSIUM ON CIRCULATORY DISORDERS OF THE LUNG. (5). CARDIAC ASTHMA].
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.
  • Tanabe T et al: Cardiac asthma: transforming growth factor-β from the failing heart leads to squamous metaplasia in human airway cells and in the murine lung.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Spreng P et al: [Siderophages in the sputum: contribution to the differential diagnosis of cardiac asthma and bronchial asthma].
  • MLCZOCH F: [BRONCHIAL ASTHMA AND CARDIAC ASTHMA--AN OLD SUBJECT IN THE LIGHT OF NEW DATA].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705919996.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. |||||||||. 1422%  Cooper IF, Siadaty MS: 'Therapeutic or Preventive Procedures' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; TherapeuticOrPreventive;AsthmaCardiac:705479096. ISSN: 2331-5717. 2014/4/30
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  • [Title] 'Therapeutic or Preventive Procedures' associated with 'Asthma Cardiac': Top Publications.
  • Background: There are articles published each month which present 'therapeutic or preventive procedure' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Perera GA et al: THE RELATION OF POSTURAL HEMODILUTION TO PAROXYSMAL DYSPNEA.
  • REINIKAINEN M et al: [A CASE OF CARDIAC ASTHMA SUCCESSFULLY TREATED WITH INTERMITTENT POSITIVE PRESSURE BREATHING].
  • Thottathil P et al: Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists.
  • Harding AV et al: Biofeedback training of cardiac acceleration; effects on airway resistance in bronchial asthma.
  • Gol'dberg GA et al: [Therapeutic use of nitroglycerin in pulmonary edema and cardiac asthma in myocardial infarct patients].
  • Aranda JM Jr et al: Dobutamine-related asthma in a patient awaiting cardiac transplantation: the eosinophilic dilemma.
  • Riding WD et al: The bronchodilator and cardiac effects of five pressure-packed aerosols in asthma.
  • Josephson GW et al: Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
  • Chiang VW et al: Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705479096.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. |||||||||. 1264%  Cooper IF, Siadaty MS: 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Asthma Cardiac': Top Publications. BioMedLib Review; PharmacologicSubstanceAntibiotic;AsthmaCardiac:705491824. ISSN: 2331-5717. 2014/5/2
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  • [Title] 'Pharmacologic Substances or Antibiotics or Clinical Drugs' associated with 'Asthma Cardiac': Top Publications.
  • Background: There are articles published each month which present 'pharmacologic substance or antibiotic or clinical drug' for 'asthma cardiac'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Vilsvik JS et al: Effect of atenolol on ventilatory and cardiac function in asthma.
  • Milner AD et al: Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
  • Martinez-Sabater H et al: Can adenosine cause asthma-like symptoms in patients with cardiac arrhythmias receiving atenolol?.
  • Al-Hillawi AH et al: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and slow release terbutaline for asthma.
  • Harrison P: Incidence of cardiac arrhythmias in patients taking slow release salbutamol and terbutaline for asthma.
  • Mukharliamov NM et al: [Possibilities for using peripheral vasodilator agents in cardiac asthma and threatened pulmonary edema].
  • Takatsu T et al: [Management of congestive heart failure (2). Diuretic administration and vasodilator therapy of cardiac asthma and pulmonary edema (cardiac load reduction) with special reference to SQ 14225 (captopril)].
  • Martelli NA et al: Asthma, cardiac arrhythmias, and albuterol aerosol.
  • Meluzín J et al: [Cardiac asthma after nifedipine and diltiazem].
  • Wilcox PG et al: Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705491824.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. |......... 3%  Zaĭtseva OV: [The approaches to diagnostics and therapy of allergic rhinitis]. Vestn Otorinolaringol; 2011;(5):62-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Allergic rhinitis is a common disease of great socio-economic significance.
  • The treatment of this condition is carried out on an individual basis depending on the clinical course of the disease; it includes prevention of contacts with the allergen, medicamental and immunotherapy.
  • The principal pharmaceuticals used to treat the patients include oral and intranasal H1 anti-histaminic preparations, intranasal corticosteroids, intranasal cromones, anti-leukotrien agents, and specific subcutaneous immunotherapy.
  • Glencet (levocetirizine) is one of the modern antihistaminic preparations of the second generation having an advantage over other drugs for the treatment of allergic rhinitis in that it may be prescribed to the patients presenting with concomitant bronchial asthma and cardiac diseases.
  • [MeSH-major] Cetirizine. Histamine H1 Antagonists, Non-Sedating. Rhinitis, Allergic, Perennial / diagnosis. Rhinitis, Allergic, Perennial / drug therapy. Rhinitis, Allergic, Seasonal / diagnosis. Rhinitis, Allergic, Seasonal / drug therapy

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  • (PMID = 22334929.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Histamine H1 Antagonists, Non-Sedating; 6U5EA9RT2O / levocetirizine; YO7261ME24 / Cetirizine
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19. |......... 2%  Pagnoux C, Mahendira D, Laskin CA: Fertility and pregnancy in vasculitis. Best Pract Res Clin Rheumatol; 2013 Feb;27(1):79-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The potential impact of vasculitis therapies, particularly cyclophosphamide, has been examined to some extent, but data are limited on the possible impact of the disease itself on fertility.
  • Most maternal complications during pregnancy are indeed due to vasculitis damage: hypertension in Takayasu arteritis (TAK) or granulomatosis with polyangiitis (GPA)/microscopic polyangiitis (MPA) with renal insufficiency, asthma or cardiac damage in eosinophilic granulomatosis with polyangiitis (EGPA) and subglottic and/or bronchial stenosis(es) in GPA.
  • Pregnancy loss can occur in about 10% of cases in GPA, up to 20% in EGPA, 20-30% in Behçet's disease and up to 25% in TAK, and several studies found high rates of preterm births, at least with some vasculitides.

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  • [Copyright] Copyright © 2013 Elsevier Ltd. All rights reserved.
  • (PMID = 23507059.001).
  • [ISSN] 1532-1770
  • [Journal-full-title] Best practice & research. Clinical rheumatology
  • [ISO-abbreviation] Best Pract Res Clin Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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20. |......... 2%  Eliahu S, Martín-Gil A, Perez de Lara MJ, Pintor J, Camden J, Weisman GA, Lecka J, Sévigny J, Fischer B: 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. J Med Chem; 2010 Apr 22;53(8):3305-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Extracellular nucleotides can modify the production or drainage of the aqueous humor via activation of P2 receptors and therefore affect the intraocular pressure (IOP).
  • Analogue 9 was more effective at reducing IOP than several common glaucoma drugs and represents a promising alternative to timolol maleate, which cannot be used for the treatment of patients suffering from asthma or cardiac problems.

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  • (PMID = 20337495.001).
  • [ISSN] 1520-4804
  • [Journal-full-title] Journal of medicinal chemistry
  • [ISO-abbreviation] J. Med. Chem.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 49460; Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / P2RY1 protein, human; 0 / Purinergic P2 Receptor Agonists; 0 / Receptors, Purinergic P2Y1; 61D2G4IYVH / Adenosine Diphosphate; 8L70Q75FXE / Adenosine Triphosphate
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21. |......... 2%  Spraley L: Corneal burns associated with phacoemulsification. Insight; 2012;37(1):15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Corneal burns associated with phacoemulsification.
  • Corneal burns can have devastating surgical results.
  • [MeSH-major] Cornea / injuries. Eye Burns / etiology. Intraoperative Complications. Phacoemulsification / adverse effects. Wounds, Nonpenetrating / etiology

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  • (PMID = 22439353.001).
  • [ISSN] 1060-135X
  • [Journal-full-title] Insight (American Society of Ophthalmic Registered Nurses)
  • [ISO-abbreviation] Insight
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. |......... 2%  O'Reilly P, Malhotra R: Our experience with the masquerade procedure for total eyelid loss. Orbit; 2010 Dec;29(6):313-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The first case suffered a partial de-gloving injury with a right sided anterior exenteration and loss of the upper and lower eyelids.
  • The cornea of the left eye was completely exposed and required urgent coverage.
  • The second case was involved in a light aircraft crash and suffered extensive facial burns with periocular involvement bilaterally.
  • RESULTS: In the first patient, poor eyelid closure led to corneal ulceration and scarring.
  • A repeat procedure involved the use of a cheek rotation flap, and ultimately the fashioning of a small port-hole aperture inferiorly to avoid corneal exposure.
  • The second patient had two attempts at a masquerade procedure, however the poor blood supply led to complete and partial failure of the first and second procedures respectively.
  • [MeSH-minor] Blepharoplasty / methods. Corneal Diseases / prevention & control. Follow-Up Studies. Graft Survival. Humans. Injury Severity Score. Male. Middle Aged. Postoperative Care / methods. Risk Assessment. Wound Healing / physiology

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  • (PMID = 20954845.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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23. |......... 2%  Semba S, Shimizudani N, Nakamura H, Odaka T, Miura H, Utsumi K, Serizawa H, Kioi K, Yagyu H, Nemoto K, Itou M, Adachi H, Kishi K, Oh-ishi S, Matsuoka T: [A case of posterior mediastinal mature teratoma]. Nihon Kokyuki Gakkai Zasshi; 2009 Jan;47(1):81-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The chest radiograph of a 57-year-old man, complaining of paroxysmal dyspnea, suggested the probably of a tumor.
  • Chest MRI suggested lipid components and a cystic lesion within the tumor.

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  • (PMID = 19198243.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 18
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24. |......... 2%  Aslan G: Postnasal drip due to inferior turbinate perforation after radiofrequency turbinate surgery: A case report. Allergy Rhinol (Providence); 2013;4(1):e17-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postnasal drip due to inferior turbinate perforation after radiofrequency turbinate surgery: A case report.
  • Management of inferior turbinate hypertrophy includes surgical options in case of failure with medical treatment and the main goal of turbinate surgery is to relieve the patient's symptoms of chronic nasal congestion while preserving mucosal surfaces with reduction of the submucosal and bony tissue.
  • Historical detail on onset, timing, duration, and severity of symptoms and aggravating and relieving factors are important in the differential diagnosis of postnasal drip (PND).
  • Here, we report development of intractable PND due to inferior turbinate perforation after radiofrequency turbinate surgery for the first time in the literature and the successful improvement via removal of pathological anatomic structure under nasal endoscopy-directed surgery in a 35-year-old female patient.

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  • (PMID = 23772320.001).
  • [ISSN] 2152-6575
  • [Journal-full-title] Allergy & rhinology (Providence, R.I.)
  • [ISO-abbreviation] Allergy Rhinol (Providence)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3679561
  • [Keywords] NOTNLM ; Complication / differential diagnosis / endoscopy / inferior turbinate hypertrophy / inferior turbinate perforation / nasal obstruction / postnasal drip / postseptorinoplasty / postturbinoplasty / radiofrequency turbinate surgery
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25. |......... 2%  Ivell R, Heng K, Nicholson H, Anand-Ivell R: Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring. Asian J Androl; 2013 Mar;15(2):261-8
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  • In this study, Sprague-Dawley rats were exposed to dibutyl phthalate (DBP; from gestational day (GD) 14.5 to postnatal day (PND) 6) or diethylstilbestrol (DES; from GD14.5 to GD16.5) during a short gestational/lactational window, and male offspring subsequently analysed for various postnatal testicular parameters.
  • Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory.
  • Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics.

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  • (PMID = 23314658.001).
  • [ISSN] 1745-7262
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Endocrine Disruptors; 0 / Insulin; 0 / Leydig insulin-like protein; 0 / Proteins; 0 / Xenobiotics; 2286E5R2KE / Dibutyl Phthalate; 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC3739150
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26. |......... 2%  Cocetti M, Taddei JA, Konstantyner T, Konstantyner TC, Barros Filho AA: Prevalence and factors associated with overweight among Brazilian children younger than 2 years. J Pediatr (Rio J); 2012 Nov-Dec;88(6):503-8
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  • METHODS: Data for the Women and Children National Demography and Health Survey (PNDS 2006) were collected using questionnaires and anthropometric measurements.
  • According to a fitted multiple logistic regression model, factors associated with overweight were: birth weight ≥ 3 kg [odds ratio (OR) = 5.2, 95% confidence interval (95%CI) 2.56-10.56], per capita income ≥ 1 minimum wage (OR = 2.50, 95%CI 1.20-5.21), residence in midwestern region (OR = 2.40, 95%CI 1.01-5.72).

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  • (PMID = 23269984.001).
  • [ISSN] 1678-4782
  • [Journal-full-title] Jornal de pediatria
  • [ISO-abbreviation] J Pediatr (Rio J)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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27. |......... 2%  Shi D, Xu S, Waddell J, Scafidi S, Roys S, Gullapalli RP, McKenna MC: Longitudinal in vivo developmental changes of metabolites in the hippocampus of Fmr1 knockout mice. J Neurochem; 2012 Dec;123(6):971-81
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  • In this study, magnetic resonance imaging (MRI) and (1) H magnetic resonance spectroscopy (MRS) were used to determine in vivo longitudinal changes in volume and metabolites in the hippocampus during the critical period of early myelination and synaptogenesis at post-natal days (PND) 18, 21, and 30 in Fmr1 KO mice compared with wild-type (WT) controls.
  • Ins was decreased at PND 30, and taurine was increased at all ages studied in Fmr1 KO mice compared with controls.
  • [MeSH-minor] Age Factors. Animals. Critical Period (Psychology). Disease Models, Animal. Fragile X Syndrome / genetics. Fragile X Syndrome / metabolism. Fragile X Syndrome / physiopathology. Longitudinal Studies. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Myelin Sheath / physiology. Synapses / metabolism. Synapses / physiology

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  • [Copyright] © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.
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  • (PMID = 23046047.001).
  • [ISSN] 1471-4159
  • [Journal-full-title] Journal of neurochemistry
  • [ISO-abbreviation] J. Neurochem.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K08 NS069815; United States / NICHD NIH HHS / HD / NIH P01 HD016596; United States / NICHD NIH HHS / HD / P01 HD016596
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Fmr1 protein, mouse; 139135-51-6 / Fragile X Mental Retardation Protein
  • [Other-IDs] NLM/ NIHMS434452; NLM/ PMC3957333
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28. |......... 2%  Marriott AL, Ryan CL, Doucette TA: Neonatal domoic acid treatment produces alterations to prepulse inhibition and latent inhibition in adult rats. Pharmacol Biochem Behav; 2012 Dec;103(2):338-44
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  • Schizophrenia is a complex and severe mental disorder characterized by positive, negative and cognitive symptoms.
  • Characteristic behavioral alterations reflecting these categories of symptoms have been observed in many animal models of this disorder, and are consistent with those manifested in the clinical population.
  • In the present experiment, daily subcutaneous (s.c.) injections of 20μg/kg of domoic acid (DOM) were administered to rat pups from postnatal days (PND) 8-14.
  • These results suggest that early treatment with DOM may serve as a useful tool to model schizophrenia which in turn may lead to a better understanding of the contribution of glutamate, and in particular, kainate receptors, to the development and/or manifestation of schizophrenia or schizophrenia-like symptoms in the clinical population.
  • [MeSH-minor] Animals. Animals, Newborn. Disease Models, Animal. Female. Male. Rats. Rats, Sprague-Dawley

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22981693.001).
  • [ISSN] 1873-5177
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] M02525818H / domoic acid; SIV03811UC / Kainic Acid
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29. |......... 2%  Cambiaghi M, Cursi M, Monzani E, Benfenati F, Comi G, Minicucci F, Valtorta F, Leocani L: Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice. Epilepsy Res; 2013 Feb;103(2-3):153-60
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  • Syn-TKO mice were studied from 20 postnatal days (PND) up to 6 months of age by video-EEG recording and behavioral observation.
  • Syn-TKO revealed rare spontaneous seizures and increased susceptibility to evoked seizures in mice from 60 to 100 PND.
  • Spectral analysis of background EEG evidenced a slowing of the theta-alpha peak in Syn-TKO mice compared to WT mice within the period from PND 40 to 100.
  • These data indicate that Syn-TKO mice do not exhibit a linear progression of the epileptic phenotype, with the period corresponding to a higher susceptibility to evoked seizures characterized by background EEG slowing.
  • [MeSH-minor] Animals. Disease Progression. Electroencephalography / methods. Female. Male. Mice. Mice, Inbred C57BL. Mice, Knockout. Random Allocation. Time Factors

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
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  • (PMID = 22846639.001).
  • [ISSN] 1872-6844
  • [Journal-full-title] Epilepsy research
  • [ISO-abbreviation] Epilepsy Res.
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP09134; Italy / Telethon / / GTF09022
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Synapsins
  • [Other-IDs] NLM/ PMC3574234
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30. |......... 2%  Kobayashi K, Kubota H, Ohtani K, Hojo R, Miyagawa M: Lack of effects for dietary exposure of bisphenol A during in utero and lactational periods on reproductive development in rat offspring. J Toxicol Sci; 2012;37(3):565-73
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  • Pregnant female Sprague-Dawley rats (F(0)) were fed a diet containing low doses of BPA (0, 0.33, 3.3, or 33 ppm) from gestational day (GD) 6 through postnatal day (PND) 21.

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  • (PMID = 22687996.001).
  • [ISSN] 1880-3989
  • [Journal-full-title] The Journal of toxicological sciences
  • [ISO-abbreviation] J Toxicol Sci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Hormones; 0 / Phenols; MLT3645I99 / bisphenol A
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31. |......... 2%  Daly FM, Hughes RN, Woodward LJ: Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively. Pharmacol Biochem Behav; 2012 Aug;102(2):381-9
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  • Following weaning on postnatal day (PND) 28, individual rats were weighed and inspected for physical abnormalities and stress reactions at PND20, 60 and 120.
  • The subsequent behavioral effects of methadone were largely confined to lactational exposure and, when combined with gestational exposure, suggested increased anxiety.

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22634063.001).
  • [ISSN] 1873-5177
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] UC6VBE7V1Z / Methadone
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32. |......... 2%  Osborn T: Training health visiting support staff to detect likelihood of possible postnatal depression. Community Pract; 2012 Apr;85(4):24-7
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  • [Title] Training health visiting support staff to detect likelihood of possible postnatal depression.
  • The acute shortage of HVs and increased workloads has resulted in routine services normally provided by HVs, such as detection/screening for postnatal depression, no longer being offered.
  • A training programme for CNNs and HVAs in the use of detector questions in assisting the possible detection of women at risk of PND was completed by eight CNNs and eight HVAs.
  • Twelve trainees consolidated the taught sessions involving specific learning outcomes and satisfactory completion of a designated competency framework within the clinical setting at the six-to-eight-week child health review in 15 GP practices.

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  • (PMID = 22586865.001).
  • [ISSN] 1462-2815
  • [Journal-full-title] Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association
  • [ISO-abbreviation] Community Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. |......... 2%  Harshaw C, Alberts JR: Group and individual regulation of physiology and behavior: a behavioral, thermographic, and acoustic study of mouse development. Physiol Behav; 2012 Jul 16;106(5):670-82
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  • Litters of mice were placed in a chamber on Postnatal Day (PND) 2, 4, or 8, in which the ambient temperature (T(a)) gradually cycled (over 50 min) from warm (36.5°C) to cool (20°C) and back (to 36.5°C).

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
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  • (PMID = 22580514.001).
  • [ISSN] 1873-507X
  • [Journal-full-title] Physiology & behavior
  • [ISO-abbreviation] Physiol. Behav.
  • [Language] eng
  • [Grant] United States / NIMH NIH HHS / MH / R01 MH082019; United States / NIMH NIH HHS / MH / R01-MH082019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS376469; NLM/ PMC3377822
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34. |......... 2%  Schneider T, Bizarro L, Asherson PJ, Stolerman IP: Hyperactivity, increased nicotine consumption and impaired performance in the five-choice serial reaction time task in adolescent rats prenatally exposed to nicotine. Psychopharmacology (Berl); 2012 Oct;223(4):401-15
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  • RATIONALE: Prenatal exposure to nicotine has been linked to accelerated risk for different psychiatric disorders, including conduct disorder, attention deficit hyperactivity disorder (ADHD) and drug abuse.
  • METHODS: Adolescent offspring of females exposed during pregnancy to 0.06 mg/ml nicotine solution as the only source of water and of a group of pair-fed females, used as a control for anorexic effects of nicotine, were evaluated in a battery of tests, including locomotor activity, the elevated plus maze, two-bottle free-choice nicotine solution consumption, the five-choice serial reaction time test (5-CSRTT) and a delay-discounting test.
  • All tests were conducted between postnatal day (PND) 25 and PND 50.

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  • (PMID = 22562524.001).
  • [ISSN] 1432-2072
  • [Journal-full-title] Psychopharmacology
  • [ISO-abbreviation] Psychopharmacology (Berl.)
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 079314
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Nicotinic Agonists; 54-11-5 / Nicotine
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35. |......... 2%  He Z, Paule MG, Ferguson SA: Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. Neurotoxicol Teratol; 2012 May-Jun;34(3):331-7
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  • [Title] Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21.
  • Here, effects of pre- and post-natal treatment with low BPA doses on SDN-POA volume of postnatal day (PND) 21 Sprague-Dawley rats were evaluated.
  • On PND 21, offspring (n=10-15/sex/group; 1/sex/litter) were perfused and volume evaluation was conducted blind to treatment.

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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 22507915.001).
  • [ISSN] 1872-9738
  • [Journal-full-title] Neurotoxicology and teratology
  • [ISO-abbreviation] Neurotoxicol Teratol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Phenols; MLT3645I99 / bisphenol A
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36. |......... 2%  Wang J, Tai F, Yu P, Wu R: Reinforcing properties of pups versus cocaine for fathers and associated central expression of Fos and tyrosine hydroxylase in mandarin voles (Microtus mandarinus). Behav Brain Res; 2012 Apr 21;230(1):149-57
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  • Our data showed that fathers developed strong preferences for pups at various times (postnatal day 5–9, 13–17 and 19–23) without cocaine conditioning.
  • Although they preferred cocaine over postnatal day (PND) 5–9 pups, this preference was not detected for PND 13–17 pups.
  • Fathers preferring cocaine exhibited an increase in Fos-immunoreactive neurons in the accumbens,medial nucleus of the amygdala, cingulate cortex, medial preoptic area and ventral tegmental area and had more TH-IR neurons in the ventral tegmental area compared to fathers preferring PND 5–9 pups.
  • A preference for cocaine over pups arose from the release of more dopamine and activation of a greater number of neurons within specific reward-associated neuronal subsets.

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  • [Copyright] 2012 Elsevier B.V. All rights reserved
  • (PMID = 22454845.001).
  • [ISSN] 1872-7549
  • [Journal-full-title] Behavioural brain research
  • [ISO-abbreviation] Behav. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Dopamine Uptake Inhibitors; 0 / Proto-Oncogene Proteins c-fos; EC 1.14.16.2 / Tyrosine 3-Monooxygenase; I5Y540LHVR / Cocaine
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37. |......... 2%  Hutchison MA, Riley AL: Ethanol exposure during either adolescence or adulthood alters the rewarding effects of cocaine in adult rats. Pharmacol Biochem Behav; 2012 May;101(3):458-64
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  • METHODS: Male rats were exposed to intraperitoneal (IP) injections of ethanol or vehicle for 10 days [postnatal days (PNDs) 30-39 or PNDs 70-79; 2 mg/kg].
  • Place preference conditioning began on PND 65 or PND 105, respectively, and consisted of a baseline test followed by four conditioning cycles with either 0, 5, 10 or 20 mg/kg cocaine.
  • [MeSH-minor] Animals. Cocaine-Related Disorders / etiology. Cocaine-Related Disorders / psychology. Conditioning (Psychology). Disease Models, Animal. Dose-Response Relationship, Drug. Injections, Intraperitoneal. Male. Rats. Rats, Sprague-Dawley

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22366218.001).
  • [ISSN] 1873-5177
  • [Journal-full-title] Pharmacology, biochemistry, and behavior
  • [ISO-abbreviation] Pharmacol. Biochem. Behav.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 3K9958V90M / Ethanol; I5Y540LHVR / Cocaine
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38. |......... 2%  Sitarek K, Stetkiewicz J, Wąsowicz W: Evaluation of reproductive disorders in female rats exposed to N-methyl-2-pyrrolidone. Birth Defects Res B Dev Reprod Toxicol; 2012 Jun;95(3):195-201
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  • [Title] Evaluation of reproductive disorders in female rats exposed to N-methyl-2-pyrrolidone.
  • On the first postnatal day (PND 1), the live and dead pups were counted, weighed, and gender was determined.
  • On PND 4, the litters were culled to eight animals each and balanced for gender.

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  • [Copyright] © 2012 Wiley Periodicals, Inc.
  • (PMID = 22311695.001).
  • [ISSN] 1542-9741
  • [Journal-full-title] Birth defects research. Part B, Developmental and reproductive toxicology
  • [ISO-abbreviation] Birth Defects Res. B Dev. Reprod. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Pyrrolidinones; 26138-58-9 / N-methylpyrrolidone
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39. |......... 2%  Cesca F, Yabe A, Spencer-Dene B, Arrigoni A, Al-Qatari M, Henderson D, Phillips H, Koltzenburg M, Benfenati F, Schiavo G: Kidins220/ARMS is an essential modulator of cardiovascular and nervous system development. Cell Death Dis; 2011;2:e226
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  • Moreover, the neuronal-specific deletion of this protein leads to early postnatal death, showing that Kidins220 also has a critical function in the postnatal brain.
  • [MeSH-minor] Animals. Cell Death / physiology. Immunohistochemistry. Mice. Mice, Transgenic

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  • (PMID = 22048169.001).
  • [ISSN] 2041-4889
  • [Journal-full-title] Cell death & disease
  • [ISO-abbreviation] Cell Death Dis
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP09134; United Kingdom / British Heart Foundation / / RG/07/007/23635; United Kingdom / British Heart Foundation / / RG/07/07; United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Cancer Research UK / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Kidins220 protein, mouse; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC3223693
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40. |......... 2%  Nickbakhsh S, Matthews L, Bessell PR, Reid SW, Kao RR: Generating social network data using partially described networks: an example informing avian influenza control in the British poultry industry. BMC Vet Res; 2011;7:66
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  • BACKGROUND: Targeted sampling can capture the characteristics of more vulnerable sectors of a population, but may bias the picture of population level disease risk.
  • Avian influenza (AI) control planning in Great Britain (GB) provides one example where network data for the poultry industry (the Poultry Network Database or PND), targeted large premises and is consequently demographically biased.
  • These data will be important for informing the control of potential future disease outbreaks.
  • RESULTS: The PND was used to compute between-farm association frequencies, assuming that farms sharing the same slaughterhouse or catching company, or through integration, are potentially epidemiologically linked.
  • This comparison showed how systematic biases in the demographic characterisation of a network, resulting from targeted sampling procedures, can bias the derived picture of between-host connectivity within the network.
  • CONCLUSIONS: With particular reference to the predictive modeling of AI in GB, we find significantly different connectivity patterns across GB when network estimates incorporate the more demographically representative information provided by the GBPR; this has not been accounted for by previous epidemiological analyses.
  • [MeSH-major] Disease Outbreaks / veterinary. Influenza A Virus, H5N1 Subtype / isolation & purification. Influenza in Birds / epidemiology. Models, Statistical. Poultry. Social Networking

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  • (PMID = 22027039.001).
  • [ISSN] 1746-6148
  • [Journal-full-title] BMC veterinary research
  • [ISO-abbreviation] BMC Vet. Res.
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / 081696; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3275467
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41. |......... 2%  Piyamongkol W, Vutyavanich T, Sanguansermsri T: Preimplantation genetic diagnosis of alpha-thalassemia-SEA using novel multiplex fluorescent PCR. J Assist Reprod Genet; 2012 Jan;29(1):95-102
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  • PURPOSE: Preimplantation genetic diagnosis (PGD) is an alternative to prenatal diagnosis (PND) giving couples at risk a chance to start a pregnancy with a disease-free baby.
  • This study aimed to develop a new PGD protocol for alpha-thalassemia(-SEA) mutation, the commonest Mendelian disorder.
  • A couple experienced termination of pregnancy following positive PND decided to join the project.
  • PND confirmed the heterozygous result.


42. |......... 2%  Dinsdale EC, Chen J, Ward WE: Early life exposure to isoflavones adversely affects reproductive health in first but not second generation female CD-1 mice. J Nutr; 2011 Nov;141(11):1996-2002
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  • CD-1 mice were bred and F1 mouse offspring were cross-fostered at birth and randomized to 1 of 4 treatments: 7 mg soy isoflavones · kg body weight(-1) · d(-1) or corn oil from postnatal d (PND) 1 to 10 or from PND 1 to 21 (n = 8-13 females/group).
  • Mice were subsequently bred to control males on PND 56 to obtain F2 females (n = 10-15/group).

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  • (PMID = 21940509.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / 89941
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoflavones
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43. |......... 2%  Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR: Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Toxicol Appl Pharmacol; 2011 Nov 15;257(1):122-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A physiologically based pharmacokinetic (PBPK) model was developed for bisphenol A (BPA) in adult rhesus monkeys using intravenous (iv) and oral bolus doses of 100 μg d6-BPA/kg (Doerge et al., 2010).
  • Using two versions of the adult monkey model based on monkey BPA kinetic data from Doerge et al. (2010) and Taylor et al. (2011), the aglycone BPA pharmacokinetics were simulated for human oral ingestion of 5 mg d16-BPA per person (Völkel et al., 2002).
  • Völkel et al. were unable to detect the aglycone BPA in plasma, but were able to detect BPA metabolites.
  • These human model predictions of the aglycone BPA in plasma were then compared to previously published PBPK model predictions obtained by simulating the Völkel et al. kinetic study.
  • BPA was metabolized at all ages of monkey (PND 5 to adult) by the gut wall and liver.
  • The use of the current non-human primate BPA model parameters provides more confidence in predicting the aglycone BPA in serum levels in humans after oral ingestion of BPA.

  • HSDB. structure - BISPHENOL A DISODIUM SALT.
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  • [Copyright] Published by Elsevier Inc.
  • (PMID = 21920375.001).
  • [ISSN] 1096-0333
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Benzhydryl Compounds; 0 / Phenols; MLT3645I99 / bisphenol A
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44. |......... 2%  Shukla M, Kumar P, Mishra V, Chaudhari BP, Munjal AK, Tripathi SS, Raisuddin S, Paul BN: Carryover of cigarette smoke effects on hematopoietic cytokines to F1 mouse litters. Mol Immunol; 2011 Sep;48(15-16):1809-17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The levels of granulocyte-macrophage colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF), interleukin-6 (IL-6), IL-1β and TNF-α mRNA and protein were evaluated in the bone marrow, amniotic fluid and bronchoalveolar lavage fluid (BALF) of F(0) dams at gestation day(14) (gd(14)) and the bone marrow, BALF and lungs of F(0) dams and F(1) littermates at post natal day(21) (pnd(21)).
  • At gd(14), overexpression of GM-CSF, G-CSF and IL-6 mRNA and protein was observed in the bone marrow, amniotic fluid and BALF of F(0) dams.
  • These hematopoietic cytokines were also overexpressed in the lungs of F(1) littermates compared with the control F(1) litters at pnd(21).
  • Lineage-specific hematopoietic growth factors may play an important role in the transmission of neutrophil-associated disease susceptibility across generations.

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.
  • (PMID = 21636132.001).
  • [ISSN] 1872-9142
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-1beta; 0 / Interleukin-6; 0 / Tobacco Smoke Pollution; 0 / Tumor Necrosis Factor-alpha; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 83869-56-1 / Granulocyte-Macrophage Colony-Stimulating Factor
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45. |......... 2%  Wang ZJ, Song L, Guo LC, Yin M, Sun YN: Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism. Yakugaku Zasshi; 2011;131(6):993-1000
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Panaxydol (PND) is one of the main non-peptidyl small molecules isolated from the lipophilic fractions of Panax notoginseng.

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  • (PMID = 21628989.001).
  • [ISSN] 1347-5231
  • [Journal-full-title] Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • [ISO-abbreviation] Yakugaku Zasshi
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Diynes; 0 / Drugs, Chinese Herbal; 0 / Fatty Alcohols; 0 / Panax notoginseng extract; 72800-72-7 / panaxydol; E0399OZS9N / Cyclic AMP; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
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46. |......... 2%  Curran CP, Nebert DW, Genter MB, Patel KV, Schaefer TL, Skelton MR, Williams MT, Vorhees CV: In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect; 2011 Sep;119(9):1286-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
  • Dams received a mixture of three coplanar and five noncoplanar PCBs on gestational day 10.5 and postnatal day (PND) 5.
  • CONCLUSIONS: High levels of maternal hepatic CYP1A2 offer the most important protection against deficits in learning and memory in offspring exposed to a mixture of coplanar and noncoplanar PCBs.

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  • (PMID = 21571617.001).
  • [ISSN] 1552-9924
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / P30-ES006096; United States / NIEHS NIH HHS / ES / R01-ES008147; United States / NIEHS NIH HHS / ES / R01-ES014403; United States / NIEHS NIH HHS / ES / R21-ES015335; United States / NIDDK NIH HHS / DK / T32-DK059803; United States / NIEHS NIH HHS / ES / T32-ES007051
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biogenic Monoamines; 0 / Complex Mixtures; 0 / Receptors, Aryl Hydrocarbon; DFC2HB4I0K / Polychlorinated Biphenyls; EC 1.14.14.1 / Cytochrome P-450 CYP1A2
  • [Other-IDs] NLM/ PMC3230394
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47. |......... 2%  Chen T, Zhang L, Yue JQ, Lv ZQ, Xia W, Wan YJ, Li YY, Xu SQ: Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring. Reprod Toxicol; 2012 Jul;33(4):538-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lung samples from postnatal day (PND) 0 and 21 pups were analyzed for the toxic effects of PFOS.
  • The results indicate that oxidative stress and both intrinsic and extrinsic cell death pathways were involved in prenatal PFOS exposure-induced injuries in postnatal lungs.

  • HSDB. structure - PERFLUOROOCTANE SULFONIC ACID.
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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21440054.001).
  • [ISSN] 1873-1708
  • [Journal-full-title] Reproductive toxicology (Elmsford, N.Y.)
  • [ISO-abbreviation] Reprod. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkanesulfonic Acids; 0 / Environmental Pollutants; 0 / Fluorocarbons; 1763-23-1 / perfluorooctane sulfonic acid; 9007-43-6 / Cytochromes c
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48. |......... 2%  Pochettino AA, Bongiovanni B, Duffard RO, Evangelista de Duffard AM: Oxidative stress in ventral prostate, ovary, and breast by 2,4-dichlorophenoxyacetic acid in pre- and postnatal exposed rats. Environ Toxicol; 2013 Jan;28(1):1-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oxidative stress in ventral prostate, ovary, and breast by 2,4-dichlorophenoxyacetic acid in pre- and postnatal exposed rats.
  • The purpose of this study was to determine the possible effects of pre- and postnatal exposure to 2,4-D on oxidative stress in ventral prostate, ovary and breast.
  • Then, the pups were sacrificed by decapitation at postnatal day (PND) 45, 60, or 90.

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  • [Copyright] Copyright © 2011 Wiley Periodicals, Inc.
  • (PMID = 21374790.001).
  • [ISSN] 1522-7278
  • [Journal-full-title] Environmental toxicology
  • [ISO-abbreviation] Environ. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Reactive Oxygen Species; 2577AQ9262 / 2,4-Dichlorophenoxyacetic Acid
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49. |......... 2%  Suárez J, Rivera P, Llorente R, Romero-Zerbo SY, Bermúdez-Silva FJ, de Fonseca FR, Viveros MP: Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus. Brain Res; 2010 Aug 19;1349:162-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Early maternal deprivation (MD) in rats (24h, PND 9-10) is a model for neurodevelopmental stress.
  • The expression of the enzymes was evaluated by quantitative RT-PCR, immunohistochemistry, and densitometry.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20599824.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / RNA, Messenger; EC 3.1.1.23 / Monoacylglycerol Lipases; EC 3.1.1.34 / Lipoprotein Lipase
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50. |......... 2%  Lu X, Zhu W, Xie Y, Li X, Gao Y, Li F, Tian H: Near-IR core-substituted naphthalenediimide fluorescent chemosensors for zinc ions: ligand effects on PET and ICT channels. Chemistry; 2010 Jul 26;16(28):8355-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Two NIR fluorescent turn-on sensors N,N'-di-n-butyl-2-(N-{2-[bis(pyridin-2-ylmethyl)amino]ethyl})-6-(N-piperidinyl)naphthalene-1,4,5,8-tetracarboxylic acid bisimide and N,N'-di- n-butyl-2-[N,N,N'-tri(pyridin-2-ylmethyl)amino]ethyl-6-(N-piperidinyl)naphthalene-1,4,5,8-tetracarboxylic acid bisimide (PND and PNT) for Zn(2+) based on naphthalenediimide fluorophore are reported.
  • Our strategy was to choose core-substituted naphthalenediimide (NDI) as a novel NIR fluorophore and N,N-di(pyridin-2-ylmethyl)ethane-1,2-diamine (DPEA) or N,N,N'-tri(pyridin-2-ylmethyl)ethane-1,2-diamine (TPEA) as the receptor, respectively, so as to improve the selectivity to Zn(2+).
  • In the case of PND, the negligible shift in absorption and emission spectra is strongly suggestive that the secondary nitrogen atom (directly connected to the NDI moiety, N(1)) is little disturbed with Zn(2+).
  • The fluorescence enhancement of PND with Zn(2+) titration is dominated with a typical photoinduced electron-transfer (PET) process.
  • For PNT, the distinct blueshift in both absorbance and fluorescence is indicative of a combination of PET and ICT processes, which unexpectedly decreases the sensitivity to Zn(2+).
  • Due to the differential binding mode caused by the ligand effect, PND shows excellent selectivity to Zn(2+) over other metal ions, with a larger fluorescent enhancement centered at 650 nm.
  • Also both PND and PNT were successfully used to image intracellular Zn(2+) ions in the living KB cells.

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  • (PMID = 20544752.001).
  • [ISSN] 1521-3765
  • [Journal-full-title] Chemistry (Weinheim an der Bergstrasse, Germany)
  • [ISO-abbreviation] Chemistry
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Imides; 0 / Ions; 0 / Ligands; 0 / Naphthalenes; 22291-04-9 / naphthalenediimide; J41CSQ7QDS / Zinc
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