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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 50%  Popov HI, Gherman C, Rogojan L, Botar-Jid C, Barna C, Fodor D: Milwaukee shoulder syndrome associated with pigmented villonodular synovitis. Case report. Med Ultrason; 2012 Mar;14(1):67-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of the synovium usually seen in young adults, found frequently in the knee joint.

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  • (PMID = 22396943.001).
  • [ISSN] 2066-8643
  • [Journal-full-title] Medical ultrasonography
  • [ISO-abbreviation] Med Ultrason
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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2. |||||..... 45%  Rao S, Rajkumar A, Elizabeth MJ, Ganesan V, Kuruvilla S: Pathology of synovial lipomatosis and its clinical significance. J Lab Physicians; 2011 Jul;3(2):84-8
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  • [Title] Pathology of synovial lipomatosis and its clinical significance.
  • BACKGROUND: Synovial lipomatosis is a rare disorder of the synovium, commonly affecting the knee joint, resulting in joint pain, swelling, and effusion.
  • AIM: This was a study done to evaluate the disease process in synovial lipomatosis, with respect to the clinical parameters and pathological features.
  • MATERIALS AND METHODS: Case files of synovial lipomatosis diagnosed on histopathology between 2007 and 2009 were perused, to study the case history, and tissue sections were reviewed for the histomorphological changes.
  • RESULTS: Eight cases of synovial lipomatosis were diagnosed on histopathology from year 2007 to 2009, of which one occurred in the wrist joint and the rest were localized to the knee joint.
  • On histopathological examination, all the cases showed villous proliferation of the synovium, with focal and diffuse infiltration by mature adipocytes.
  • CONCLUSION: Synovial lipomatosis may mimic tumorous, lesion-like synovial lipoma or hemangioma and its distinct histomorphology helps in distinguishing it from these lesions.
  • It possibly represents a secondary phenomenon following the degenerative process of articular disease of the joints.

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  • (PMID = 22219560.001).
  • [ISSN] 0974-7826
  • [Journal-full-title] Journal of laboratory physicians
  • [ISO-abbreviation] J Lab Physicians
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3249723
  • [Keywords] NOTNLM ; Clinical / pathology / synovial lipomatosis
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3. ||||...... 38%  Driban JB, Barr AE, Amin M, Sitler MR, Barbe MF: Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol; 2011;2011:691412
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  • [Title] Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder.
  • With HRHF task performance, ED1+ and COX2+ cells were present in subchondral radius, carpal bones and synovium; IL-1alpha and TNF-alpha increased in distal radius/ulna/carpal bones; chondrocytes stained with Terminal deoxynucleotidyl Transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) increased in wrist articular cartilages; superficial structural changes (e.g., pannus) and reduced proteoglycan staining were observed in wrist articular cartilages.

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  • (PMID = 21403884.001).
  • [ISSN] 1110-7251
  • [Journal-full-title] Journal of biomedicine & biotechnology
  • [ISO-abbreviation] J. Biomed. Biotechnol.
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / AR051212; United States / NIOSH CDC HHS / OH / OH 03970; United States / NIAMS NIH HHS / AR / R01 AR056019; United States / NIAMS NIH HHS / AR / R01 AR056019-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Peptide Fragments; 0 / Procollagen; 0 / Tumor Necrosis Factor-alpha; 0 / procollagen type II carboxy-terminal peptide; 9007-34-5 / Collagen; WK2XYI10QM / Ibuprofen
  • [Other-IDs] NLM/ PMC3051200
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4. ||||...... 37%  Egloff C, Hügle T, Valderrabano V: Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly; 2012;142:w13583
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  • Today, the most frequent chronic musculoskeletal disorder and the leading cause of disability in the elderly is osteoarthritis (OA).
  • Thus, OA is a disease of the whole joint, including muscles, tendons, ligaments, synovium and bone.
  • Procedures, conservative or surgical, which actively alter the biomechanics of the lower limb, are promising strategies to treat symptoms as well as to influence disease progression in OA.
  • [MeSH-minor] Biomechanical Phenomena. Disease Progression. Fractures, Bone / complications. Humans. Inflammation / complications. Joint Instability / complications. Muscle Weakness / complications

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  • (PMID = 22815119.001).
  • [ISSN] 1424-3997
  • [Journal-full-title] Swiss medical weekly
  • [ISO-abbreviation] Swiss Med Wkly
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
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5. ||||...... 37%  Tsukuda Y, Iwasaki N, Seito N, Kanayama M, Fujitani N, Shinohara Y, Kasahara Y, Onodera T, Suzuki K, Asano T, Minami A, Yamashita T: Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. PLoS One; 2012;7(6):e40136
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  • Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States.
  • Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium of patients with RA.
  • In contrast, the amount of the GM3 synthase gene transcript in the synovium was higher in patients with RA than in those with osteoarthritis.
  • [MeSH-major] Arthritis, Rheumatoid / etiology. Arthritis, Rheumatoid / pathology. Disease Progression. G(M3) Ganglioside / metabolism
  • [MeSH-minor] Animals. Antibodies / pharmacology. Antigens, CD3 / immunology. Arthritis, Experimental / enzymology. Arthritis, Experimental / genetics. Biosynthetic Pathways / drug effects. Cell Proliferation / drug effects. Gene Deletion. Gene Expression Regulation, Enzymologic / drug effects. Humans. Immunization. Mice. Mice, Inbred C57BL. Osteoarthritis / pathology. Phenotype. RNA, Messenger / genetics. RNA, Messenger / metabolism. Sialyltransferases / deficiency. Sialyltransferases / genetics. Sialyltransferases / metabolism. Synovial Membrane / drug effects. Synovial Membrane / metabolism. Synovial Membrane / pathology. Th17 Cells / drug effects. Th17 Cells / immunology

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  • (PMID = 22768242.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD3; 0 / G(M3) Ganglioside; 0 / RNA, Messenger; EC 2.4.99.- / Sialyltransferases; EC 2.4.99.9 / haematoside synthetase
  • [Other-IDs] NLM/ PMC3387008
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6. ||||...... 37%  Al-Najjim M, Mustafa A, Fenton C, Morapudi S, Waseem M: Giant solitary synovial osteochondromatosis of the elbow causing ulnar nerve neuropathy: a case report and review of literature. J Brachial Plex Peripher Nerve Inj; 2013;8(1):1
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  • [Title] Giant solitary synovial osteochondromatosis of the elbow causing ulnar nerve neuropathy: a case report and review of literature.
  • INTRODUCTION: Giant or solitary osteochondroma is part of a rare disorder known as synovial osteochondromatosis.
  • It forms part of a spectrum of disease characterized by metaplastic changes within the joint synovium that are eventually extruded as loose bodies.
  • It has been suggested that solitary synovial osteochondroma forms as progression of synovial osteochondromatosis through a process of either coalescence of multiple smaller bodies or the growth of a dominant synovial osteochondroma.
  • Previous studies have shown that it occurs as a late phase of the disease.
  • We report a rare case of giant synovial osteochondromatosis at the elbow causing ulnar nerve neuropathy and mechanical symptoms which has not been previously reported in the literature.
  • The patient underwent MR imaging and subsequent biopsy that demonstrated synovial osteochondromatosis.
  • Five years later he returned with worsening symptoms and underwent successful surgical resection of a giant solitary synovial osteochondroma.
  • It may suggest an improved prognosis as compared to multiple synovial osteochondromatosis in terms of mechanical and neurological outcomes.

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  • (PMID = 23351253.001).
  • [ISSN] 1749-7221
  • [Journal-full-title] Journal of brachial plexus and peripheral nerve injury
  • [ISO-abbreviation] J Brachial Plex Peripher Nerve Inj
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7. ||||...... 37%  O'Rielly DD, Rahman P: Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies. Pharmgenomics Pers Med; 2010;3:15-31
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  • Rheumatoid arthritis (RA) is a chronic heterogeneous autoimmune disorder of unknown etiology resulting in inflammation in the synovium, cartilage, and bone.
  • This review will summarize the genetic factors that have been implicated in the pathogenesis of RA, and how these determinants may factor into the potential pharmacogenetics of this disease.

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  • (PMID = 23226040.001).
  • [ISSN] 1178-7066
  • [Journal-full-title] Pharmacogenomics and personalized medicine
  • [ISO-abbreviation] Pharmgenomics Pers Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3513198
  • [Keywords] NOTNLM ; pharmacogenetics / rheumatoid arthritis / susceptibility genes
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8. |||||||||. 86%  Chung CB, Boucher R, Resnick D: MR imaging of synovial disorders of the knee. Semin Musculoskelet Radiol; 2009 Dec;13(4):303-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MR imaging of synovial disorders of the knee.
  • Synovial membranes line the diarthrodial (movable) joints, bursae, and tendon sheaths of the body.
  • The synovium is affected by a variety of disorders that can be localized to a specific articulation or can be systemic in nature.
  • These include inflammatory, infectious, degenerative, traumatic, or neoplastic categories of disease.
  • Further, MR imaging provides an excellent non-invasive tool for the evaluation of the synovium and synovial-based processes.
  • This article will discuss technical considerations pertinent to the MR imaging evaluation of synovial processes in the knee; will review the synovial and bursal anatomy of the knee as well as the imaging characteristics of general synovial abnormalities and their diagnostic implications.
  • In addition, it will review specific synovial processes and their characteristic MR imaging findings.
  • [MeSH-major] Joint Diseases / pathology. Knee Joint / pathology. Magnetic Resonance Imaging / methods. Neoplasms, Connective Tissue / pathology. Synovial Membrane / pathology
  • [MeSH-minor] Bursa, Synovial / anatomy & histology. Bursa, Synovial / pathology. Humans. Image Enhancement / methods. Synovitis / pathology

  • MedlinePlus Health Information. consumer health - Joint Disorders.
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  • [Copyright] (c) Thieme Medical Publishers.
  • (PMID = 19890800.001).
  • [ISSN] 1098-898X
  • [Journal-full-title] Seminars in musculoskeletal radiology
  • [ISO-abbreviation] Semin Musculoskelet Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 113
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9. |||||||... 66%  Alaqeel MA, Al-Ahaideb A: Synovial osteochondroma originating from the synovium of the anterior cruciate ligament. BMJ Case Rep; 2013;2013
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  • [Title] Synovial osteochondroma originating from the synovium of the anterior cruciate ligament.
  • Primary synovial osteochondromatosis is a rarely seen disorder of the synovium in any joints.
  • We report an unusual case of primary synovial osteochondromatosis.
  • In addition, the sign of proliferation of synovium and cartilaginous tissues were apparent.
  • To the best of our knowledge, this is the first report to describe synovial osteochondromatosis originating from ACL fibres and has been resected while preserving the ACL.
  • [MeSH-major] Anterior Cruciate Ligament / pathology. Chondromatosis, Synovial / pathology

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  • (PMID = 23345533.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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10. ||||||.... 57%  Mavrogenis AF, Papaparaskeva KT, Galanakos S, Papagelopoulos PJ: Pigmented villonodular synovitis of the distal tibiofibular joint: a case report. Clin Podiatr Med Surg; 2011 Jun;28(3):589-97
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  • Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovium.
  • This article presents a case of PVNS with rare location at the distal tibiofibular joint and discusses the current concepts of diagnosis and treatment of this disease.

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21777788.001).
  • [ISSN] 1558-2302
  • [Journal-full-title] Clinics in podiatric medicine and surgery
  • [ISO-abbreviation] Clin Podiatr Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. |||....... 31%  Giannetti S, Santucci A, Patricola A, Stancati A, Di Sanzo V: Neglected synovial osteochondromatosis of the elbow: a rare case. World J Surg Oncol; 2013;11:233
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  • [Title] Neglected synovial osteochondromatosis of the elbow: a rare case.
  • BACKGROUND: Synovial osteochondromatosis is a benign metaplastic proliferative disorder of the synovium characterised by the formation of multiple cartilaginous nodules in the synovium, many of which detach and become loose bodies.
  • The disease is characteristically monoarticular, most commonly involving the knee.
  • Very few cases of synovial osteochondromatosis of the elbow have been reported in the literature.
  • The treatment of choice is excision of the synovium and removal of the loose bodies.
  • CASE PRESENTATION: We report a rare neglected case covering a 32-year period of a locally aggressive synovial osteochondromatosis of the elbow in a 47-year-old man.
  • CONCLUSION: Synovial osteochondromatosis is an uncommon condition characterized by the formation of multiple nodules of hyaline cartilage within the sub-synovial connective tissue.
  • The differential diagnosis includes chronic articular infection, osteoarthritis, pigmented villonodular synovitis, mono-articular inflammatory arthritis and periarticular neoplasms like synovial sarcoma.
  • The treatment of choice is excision of the synovium and removal of the loose bodies.

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  • (PMID = 24044684.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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12. |||....... 26%  Fitowska A, Ostałowska A, Dobrakowski M, Hapeta B, Kasperczyk A, Stołtny T, Koczy B, Swięchowicz S, Birkner E, Kasperczyk S: Protein metabolism in the synovial membrane in the hip osteoarthritis. Pol Orthop Traumatol; 2012;77:21-6
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  • [Title] Protein metabolism in the synovial membrane in the hip osteoarthritis.
  • The aim of this study was to compare the activity of selected enzymes and albumin and protein level in the synovial membrane obtained during hip replacement surgery due to coxarthrosis.
  • Collected sections of the synovial membrane were prepared for biochemical tests according to the authors' methodology.
  • RESULTS: In the synovial membrane of patients with hip osteoarthritis significantly higher activity of superoxide dismutase (SOD) and glutamate dehydrogenase (GLDH) was observed, as well as increased activity of prolidase and lower activity of acid phosphatase activity compared with the reference group.
  • The concentration of total protein and albumin in the synovial membrane was similar in both groups.
  • Coexisting protein metabolism disorders of the synovial membrane may contribute to the degradation of the articular cartilage.

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  • (PMID = 23306282.001).
  • [ISSN] 0009-479X
  • [Journal-full-title] Polish orthopedics & traumatology
  • [ISO-abbreviation] Pol Orthop Traumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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13. |||....... 25%  Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I: Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. Biomed Res Int; 2013;2013:607137
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  • Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the synovial membrane that results in the destruction of bone and cartilage in affected joints.
  • In order to identify novel disease-related proteins and candidate biomarkers, we analyzed the changes in the serum proteome profiles of patients with RA who were treated with tocilizumab.
  • Although some of the proteins are known to be related to RA, several are currently unknown with respect to their relationship to RA and may be involved in the development of this disease.
  • Our results may contribute to the identification of novel disease-related proteins and enhance the understanding of the pathogenesis of RA.

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 24058910.001).
  • [ISSN] 2314-6141
  • [Journal-full-title] BioMed research international
  • [ISO-abbreviation] Biomed Res Int
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3766614
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14. ||........ 24%  Li N, Wang JC, Liang TH, Zhu MH, Wang JY, Fu XL, Zhou JR, Zheng SG, Chan P, Han J: Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients. Int J Clin Exp Pathol; 2013;6(7):1375-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pathologic finding of increased expression of interleukin-17 in the synovial tissue of rheumatoid arthritis patients.
  • Rheumatoid arthritis (RA) is a common autoimmune disease of chronic systemic inflammatory disorder that will affect multiple tissues and organs such as skin, heart or lungs; but it principally attacks the joints, producing a nonsuppurative inflammatory and proliferative synovitis that often progresses to major damaging of articular cartilage and joint ankylosis.
  • Though some previous studies have shown that IL-17 exists in the synovium of RA, few has definite proof quantitatively by pathology about its existence in synovial membrane.
  • This study comprised of 30 RA patients and 10 healthy control, pathologic study of the synovial membrane showed increased expression of IL-17 in the synovial tissue of RA patients, the intensity is compatible with clinical severity of disease as validated by DAS28 score and disease duration.
  • Northern blot study also confirmed the increased expression of IL-17 in the synovial tissues.
  • This study sheds further light that IL-17 may be a key factor in the pathogenesis of RA and a determinant of disease severity.
  • [MeSH-major] Arthritis, Rheumatoid / immunology. Interleukin-17 / analysis. Synovial Membrane / immunology

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  • (PMID = 23826419.001).
  • [ISSN] 1936-2625
  • [Journal-full-title] International journal of clinical and experimental pathology
  • [ISO-abbreviation] Int J Clin Exp Pathol
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / R01 AR059103
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biological Markers; 0 / Interleukin-17
  • [Other-IDs] NLM/ PMC3693203
  • [Keywords] NOTNLM ; Rheumatoid arthritis / interleukin-17 / synovitis
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15. ||........ 24%  Noh R, Park SG, Ju JH, Chi SW, Kim S, Lee CK, Kim JH, Park BC: Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients. J Microbiol Biotechnol; 2014 Jan;24(1):119-26
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients.
  • Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disorder that primarily affects the flexible joints and may also affect a number of tissues and organs.
  • The progression of RA involves an inflammatory response of the capsule around the joint, swelling of synovial cells with excess synovial fluid (SF), and the development of fibrous tissue in the synovium.
  • Since the progressive pathology of the disease often leads to the irreversible destruction of articular cartilage and ankylosis of the joint, early diagnosis of RA is essential.

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  • (PMID = 24105271.001).
  • [ISSN] 1738-8872
  • [Journal-full-title] Journal of microbiology and biotechnology
  • [ISO-abbreviation] J. Microbiol. Biotechnol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
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16. |||||..... 54%  Edwards C, Milner S: Pigmented villonodular synovitis of second toe interphalangeal joint: Methods of imaging. Foot Ankle Surg; 2010 Jun;16(2):e34-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis is a rare proliferative disorder of the synovium of unknown aetiology.

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  • [Copyright] Copyright 2009 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20483126.001).
  • [ISSN] 1460-9584
  • [Journal-full-title] Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
  • [ISO-abbreviation] Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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17. |||||..... 53%  De Benedittis M, Turco M, Petruzzi M, Cortelazzi R: Extra-articular diffuse-type giant cell tumour of the temporomandibular joint. Int J Oral Maxillofac Surg; 2013 Mar;42(3):380-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse-type giant cell tumour (DTGCT) is a benign but destructive proliferative disorder of the synovium of joint capsules, tendons and bursae.
  • Lesions originating from the articular synovium may grow intra-articularly or expand widely extra-articularly.
  • [MeSH-major] Giant Cell Tumors / pathology. Neoplasms, Connective Tissue / pathology. Synovial Membrane / pathology. Temporomandibular Joint / pathology

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  • [Copyright] Copyright © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 22898313.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
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18. |||||..... 51%  Cai J, Cai Z, Gao Y: Pigmented villonodular synovitis of the temporomandibular joint: a case report and the literature review. Int J Oral Maxillofac Surg; 2011 Nov;40(11):1314-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVNS) is an uncommon benign proliferative disorder of synovium that may involve joints, tendon sheaths, and bursae.
  • [MeSH-major] Skull Base / pathology. Synovitis, Pigmented Villonodular / pathology. Temporomandibular Joint Disorders / pathology

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  • [Copyright] Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 21474285.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
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19. |||||..... 49%  Tel A, Spinzia A, Boggio M: Diffuse tenosynovial giant cell tumour of the temporomandibular joint. Int J Oral Maxillofac Surg; 2012 Mar;41(3):321-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tenosynovial giant cell tumour (TGCT) is a rare benign proliferative disorder of the synovium characterised by destructive invasion by synovial-like mononuclear cells.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Soft Tissue Neoplasms / diagnosis. Temporomandibular Joint Disorders / diagnosis
  • [MeSH-minor] Adult. Antigens, CD / analysis. Antigens, Differentiation, Myelomonocytic / analysis. Cell Nucleus / ultrastructure. Cytoplasm / ultrastructure. Diagnosis, Differential. Fibroblasts / pathology. Follow-Up Studies. Histiocytes / pathology. Humans. Joint Capsule / pathology. Lymphocytes / pathology. Macrophages / pathology. Male. Synovial Membrane / pathology

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  • [Copyright] Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 22177315.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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20. |||||..... 46%  Schnirring-Judge M, Lin B: Pigmented villonodular synovitis of the ankle-radiation therapy as a primary treatment to reduce recurrence: a case report with 8-year follow-up. J Foot Ankle Surg; 2011 Jan-Feb;50(1):108-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVNS) is a rare, benign, idiopathic proliferative disorder of the synovium that results in villous and or nodular formations that have been reported to manifest within joints, tendon sheaths, and bursae.
  • Although traditional treatment for PVNS includes synovectomy with arthroplasty of the affected joint, radiation therapy is now suggested as an adjunctive therapy that is believed to reduce recurrence of the disease.
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Orthopedic Procedures / methods. Pain Measurement. Postoperative Care / methods. Radiotherapy Dosage. Radiotherapy, Adjuvant. Recovery of Function. Recurrence / prevention & control. Risk Assessment. Severity of Illness Index. Synovial Membrane / radiation effects. Synovial Membrane / surgery. Time Factors. Tomography, X-Ray Computed / methods. Treatment Outcome

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  • [Copyright] Copyright © 2011 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21172644.001).
  • [ISSN] 1542-2224
  • [Journal-full-title] The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
  • [ISO-abbreviation] J Foot Ankle Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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21. |||||..... 46%  Horoschak M, Tran PT, Bachireddy P, West RB, Mohler D, Beaulieu CF, Kapp DS, Donaldson SS: External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys; 2009 Sep 1;75(1):183-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovium with locally aggressive behavior.
  • Cytoreductive surgery was performed before radiation therapy in 16/18 sites with all having proven or suspected residual disease.
  • CONCLUSION: Postoperative external beam radiation is effective in preventing disease recurrence and should be offered following maximal cytoreduction to enhance local control in PVNS.

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  • (PMID = 19211195.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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22. |||||..... 45%  Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, Kaneko H, Takasaki Y, Ogawa H, Takamori K, Sekigawa I: Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheum Dis; 2012 Oct;15(5):486-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the synovium resulting in the destruction of affected joint cartilage and bone structures.
  • In order to identify novel disease-related proteins and candidate biomarkers, we performed proteomic profiling of the serum in patients with RA who were treated with etanercept.
  • These findings could thus lead to the identification of novel candidate disease-related protein biomarkers for RA, or indicate new targets for therapy.

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  • HSDB. structure - Etanercept.
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  • [Copyright] © 2012 The Authors International Journal of Rheumatic Diseases © 2012 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
  • (PMID = 23083039.001).
  • [ISSN] 1756-185X
  • [Journal-full-title] International journal of rheumatic diseases
  • [ISO-abbreviation] Int J Rheum Dis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enkephalins; 0 / Extracellular Matrix Proteins; 0 / FBLN5 protein, human; 0 / Immunoglobulin G; 0 / Kininogens; 0 / Lipocalins; 0 / PRG4 protein, human; 0 / Protein Precursors; 0 / Proteoglycans; 0 / Proteome; 0 / Receptors, Tumor Necrosis Factor; 0 / proenkephalin; 185243-69-0 / TNFR-Fc fusion protein; EC 3.4.21.46 / Complement Factor D; EC 5.3.- / Intramolecular Oxidoreductases; EC 5.3.99.2 / prostaglandin R2 D-isomerase
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23. ||||...... 42%  Dewan AK, Chhabra AB, Khanna AJ, Anderson MW, Brunton LM: MRI of the elbow: techniques and spectrum of disease: AAOS exhibit selection. J Bone Joint Surg Am; 2013 Jul 17;95(14):e99 1-13
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  • [Title] MRI of the elbow: techniques and spectrum of disease: AAOS exhibit selection.
  • The classic MRI appearances of occult fractures, loose bodies, ulnar collateral ligament injuries, lateral collateral ligament complex injuries, biceps tendon injuries, triceps tendon injuries, lateral epicondylitis, medial epicondylitis, septic arthritis, osteomyelitis, osteochondritis dissecans, compression neuropathies, synovial disorders, and various soft-tissue masses are reviewed.

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  • (PMID = 23864190.001).
  • [ISSN] 1535-1386
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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24. ||||...... 41%  van de Sande MG, de Hair MJ, van der Leij C, Klarenbeek PL, Bos WH, Smith MD, Maas M, de Vries N, van Schaardenburg D, Dijkmans BA, Gerlag DM, Tak PP: Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase. Ann Rheum Dis; 2011 May;70(5):772-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase.
  • BACKGROUND: The aetiology of rheumatoid arthritis (RA), a prototype immune-mediated inflammatory disorder, is poorly understood.
  • It is currently unknown whether the disease process starts in the synovium, the primary target of RA, or at other sites in the body.
  • To evaluate synovial inflammatory changes, all participants underwent dynamic contrast-enhanced MRI and arthroscopic synovial biopsy sampling of a knee joint at inclusion.
  • Results were compared with knee MRI data and synovial biopsy data of 6 and 10 healthy controls, respectively.
  • RESULTS: MRI findings evaluated by measurement of maximal enhancement, rate of enhancement, synovial volume and enhancement shape curve distribution were similar between the autoantibody-positive subjects and the healthy controls.
  • CONCLUSION: Subclinical inflammation of the synovium does not coincide with the appearance of serum autoantibodies during the pre-RA stage.
  • This study supports the rationale for exploring preventive strategies aimed at interfering with the humoral immune response before synovial inflammation develops.
  • [MeSH-minor] Adult. Arthroscopy. Autoantibodies / blood. Biological Markers / blood. Biopsy. Case-Control Studies. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Peptides, Cyclic / immunology. Rheumatoid Factor / blood. Synovial Membrane / pathology. Young Adult


25. ||||...... 40%  Kubat O, Mahnik A, Smoljanović T, Bojanić I: Arthroscopic treatment of localized and diffuse pigmented villonodular synovitis of the knee. Coll Antropol; 2010 Dec;34(4):1467-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVNS) is a rare proliferative synovial disorder of uncertain etiology.
  • Two forms of this disorder, a localized (LPVNS) and diffuse (DPVNS) form, are well differentiated.
  • The diagnosis was confirmed by synovial biopsy.
  • [MeSH-minor] Adolescent. Adult. Female. Humans. Male. Middle Aged. Retrospective Studies. Synovial Membrane / surgery

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  • (PMID = 21874741.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Croatia
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26. ||||...... 40%  te Veldhuis AH, Lobbezoo F, te Veldhuis EC, Naeije M, van Selms MK: [Synovial chondromatosis of the temporomandibular joint. A systematic review of the literature on its characteristics]. Ned Tijdschr Tandheelkd; 2011 Sep;118(9):421-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Synovial chondromatosis of the temporomandibular joint. A systematic review of the literature on its characteristics].
  • [Transliterated title] Synoviale chondromatose van het temporomandibulaire gewricht. Een systematisch literatuuronderzoek naar de kenmerken.
  • Synovial chondromatosis of the temporomandibular joint is a disease which occurs rarely.
  • The disease has been identified more frequently in women than in men.
  • A part from pre-auricular swelling, the most frequently reported clinical characteristics resembled those of temporomandibular disorders.
  • Insufficient evidence was found that trauma or rheumatoid arthritis plays a role in the development of this disease.
  • Given the similarities with temporomandibular disorders, synovial chondromatosis should be considered in the differential diagnosis of patients suffering from complaints of temporomandibular dysfunction.
  • [MeSH-major] Chondromatosis, Synovial / diagnosis. Temporomandibular Joint Disorders / diagnosis

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  • (PMID = 21957638.001).
  • [ISSN] 0028-2200
  • [Journal-full-title] Nederlands tijdschrift voor tandheelkunde
  • [ISO-abbreviation] Ned Tijdschr Tandheelkd
  • [Language] dut
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Netherlands
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27. ||||...... 39%  Walker JA: Osteoarthritis: pathogenesis, clinical features and management. Nurs Stand; 2009 Sep 9-15;24(1):35-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoarthritis is a degenerative disorder of the synovial joints that is characterised by joint pain, stiffness and limited range of movement.


28. ||||...... 39%  Shelton LR: A closer look at osteoarthritis. Nurse Pract; 2013 Jul 10;38(7):30-6; quiz 36-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OA is a degenerative disorder of the synovial joint that leads to pain, stiffness, and decreased function of the affected joint.

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  • (PMID = 23728492.001).
  • [ISSN] 1538-8662
  • [Journal-full-title] The Nurse practitioner
  • [ISO-abbreviation] Nurse Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. ||||...... 39%  Steimer O, Kusma M, Grün U: [Hip arthroscopy - indications and limits]. Orthopade; 2011 Dec;40(12):1054-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The main indications for hip arthroscopy include any disorder of the synovial membrane, damage to the labrum acetabulare, lesions of the ligament of the head of the femur, loose bodies, degenerative and traumatic cartilage lesions and especially disorders of the joint mechanism caused by femoroacetabular impingement.

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  • (PMID = 22109590.001).
  • [ISSN] 1433-0431
  • [Journal-full-title] Der Orthopäde
  • [ISO-abbreviation] Orthopade
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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30. ||||...... 39%  del Carmen Baena-Ocampo L, Rosales Olivares LM, Arriaga NM, Izaguirre A, Pineda C: Pigmented villonodular synovitis of thoracic facet joint presenting as rapidly progressive paraplegia. J Clin Rheumatol; 2009 Dec;15(8):393-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovial membrane of uncertain etiology.
  • It commonly affects synovial joints of the appendicular skeleton and rarely affects the spine.

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  • (PMID = 19955996.001).
  • [ISSN] 1536-7355
  • [Journal-full-title] Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
  • [ISO-abbreviation] J Clin Rheumatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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31. ||||...... 38%  Bojanić I, Vuletić LB, Troha I, Smoljanović T, Borić I, Seiwerth S: [Synovial chondromatosis]. Lijec Vjesn; 2010 Mar-Apr;132(3-4):102-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Synovial chondromatosis].
  • Synovial chondromatosis is an uncommon benign disorder of the synovial membrane ofjoints, tendon sheaths, or bursae characterized by the formation of multiple cartilaginous nodules or osseus loose bodies.
  • It is usually a monoarticular disease, and 33 different localizations have been described until now.
  • The aim of this review article is to present the newest knowledge on the etiology, diagnosis, differential diagnosis, and management of synovial chondromatosis.
  • [MeSH-major] Chondromatosis, Synovial

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  • (PMID = 20540438.001).
  • [ISSN] 0024-3477
  • [Journal-full-title] Lijec̆nic̆ki vjesnik
  • [ISO-abbreviation] Lijec Vjesn
  • [Language] hrv
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Croatia
  • [Number-of-references] 60
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32. ||||...... 38%  Honsawek S, Tanavalee A, Yuktanandana P: Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity. Arch Med Res; 2009 Oct;40(7):590-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity.
  • BACKGROUND AND AIMS: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone.
  • The aim of this study was to evaluate endoglin levels in both plasma and synovial fluid of patients with primary knee OA and to determine their relationship with disease severity.
  • Endoglin concentrations in both plasma and synovial fluid were analyzed using a sandwich enzyme-linked immunosorbent assay.
  • Although endoglin levels in synovial fluid were higher with respect to paired plasma samples, the difference was not significant (5.41+/-0.32 vs. 5.16+/-0.22 ng/mL, p=0.3).
  • Additionally, plasma endoglin levels exhibited a positive correlation with synovial fluid endoglin levels (r=0.52, p=0.001).
  • Further analysis revealed that plasma endoglin levels significantly correlated with disease severity (r=0.38, p=0.02).
  • Furthermore, the synovial fluid levels of endoglin also positively correlated with disease severity (r=0.55, p=0.001).
  • CONCLUSIONS: These findings indicate that endoglin in plasma and synovial fluid is correlated with progressive joint damage in knee OA.
  • Endoglin is likely to be useful as a biomarker for determining disease severity and may play a possible role in the pathogenesis of osteoarthritis.
  • [MeSH-major] Antigens, CD / metabolism. Osteoarthritis, Knee / metabolism. Osteoarthritis, Knee / pathology. Receptors, Cell Surface / metabolism. Synovial Fluid / chemistry

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  • [Copyright] 2009 IMSS. Published by Elsevier Inc.
  • (PMID = 20082874.001).
  • [ISSN] 1873-5487
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Biological Markers; 0 / ENG protein, human; 0 / Receptors, Cell Surface
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33. ||||...... 38%  Honsawek S, Chayanupatkul M: Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch Med Res; 2010 Nov;41(8):593-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity.
  • BACKGROUND AND AIMS: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone.
  • The purposes of this study were to measure adiponectin concentrations in plasma and synovial fluid of patients with knee OA and to analyze the correlation of adiponectin levels with disease severity.
  • Adiponectin levels in plasma and synovial fluid were determined by commercial enzyme-linked immunosorbent assay.
  • Adiponectin levels in plasma were remarkably higher with regard to paired synovial fluid (2428.0 ± 245.1 vs. 301.3 ± 44.9 ng/mL, p <0.001).
  • Additionally, adiponectin concentrations in plasma and synovial fluid showed significant inverse correlation with disease severity evaluated by KL grading criteria (r = -0.68, p <0.001 and r = -0.47, p <0.001, respectively).
  • Further analysis showed that plasma adiponectin levels positively correlated with synovial fluid adiponectin levels (r = 0.71, p <0.001).
  • CONCLUSIONS: Adiponectin levels in both plasma and synovial fluid decreased significantly as the severity of OA increased.
  • More studies are warranted to gain insight into the potential utility of adiponectin as a biochemical determinant of disease progression and prognosis.
  • [MeSH-major] Adiponectin / blood. Osteoarthritis, Knee / blood. Osteoarthritis, Knee / physiopathology. Severity of Illness Index. Synovial Fluid / chemistry
  • [MeSH-minor] Aged. Aged, 80 and over. Disease Progression. Female. Humans. Male. Middle Aged

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  • [Copyright] Copyright © 2010 IMSS. Published by Elsevier Inc. All rights reserved.
  • (PMID = 21199727.001).
  • [ISSN] 1873-5487
  • [Journal-full-title] Archives of medical research
  • [ISO-abbreviation] Arch. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin
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34. ||||...... 38%  Moriya K, Uchiyama T, Kouda H, Kawaji Y: Acromegaly as a cause of trigger finger. Scand J Plast Reconstr Surg Hand Surg; 2009;43(4):236-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The increase in extracellular fluid can cause oedematous swelling of the flexor synovium in the digital sheath.
  • [MeSH-major] Acromegaly / complications. Reconstructive Surgical Procedures / methods. Trigger Finger Disorder / etiology
  • [MeSH-minor] Adult. Fingers / pathology. Fingers / radiography. Fingers / surgery. Humans. Male. Synovial Membrane / pathology. Synovial Membrane / surgery

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  • (PMID = 19688648.001).
  • [ISSN] 1651-2073
  • [Journal-full-title] Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi
  • [ISO-abbreviation] Scand J Plast Reconstr Surg Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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35. ||||...... 37%  Oni JK, Cavallo RJ: A rare case of diffuse pigmented villonodular synovitis after total knee arthroplasty. J Arthroplasty; 2011 Sep;26(6):978.e9-978.e11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Pigmented villonodular synovitis is a benign, proliferative disorder of unknown etiology that mainly affects the synovium of the joint, bursa, and the tendon sheath.
  • The diagnosis was suggested by histologic analysis of bloody aspirate and by abnormal synovial proliferation noted at arthroscopy and confirmed by histologic analysis of the resected tissue.
  • [MeSH-minor] Aged. Arthroscopy. Biopsy, Fine-Needle. Cell Proliferation. Humans. Male. Synovial Membrane / pathology. Synovial Membrane / surgery. Treatment Outcome

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 21256702.001).
  • [ISSN] 1532-8406
  • [Journal-full-title] The Journal of arthroplasty
  • [ISO-abbreviation] J Arthroplasty
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. ||||...... 37%  Ascherman DP: Interstitial lung disease in rheumatoid arthritis. Curr Rheumatol Rep; 2010 Oct;12(5):363-9
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  • [Title] Interstitial lung disease in rheumatoid arthritis.
  • Rheumatoid arthritis (RA) is the most common systemic autoimmune disease in the United States, affecting 1% to 2% of the adult population.
  • Although joints and synovium are the primary targets in this disorder, extra-articular manifestations involving the lungs can lead to significant morbidity and excess mortality.
  • Among the various pulmonary complications that occur in RA, interstitial lung disease (ILD) is the most damaging, with effects ranging from subclinical inflammation/scarring to end-stage pulmonary fibrosis.
  • Despite these advancements, the complexity of RA-ILD and the lack of reliable predictors for disease progression highlight the need for improved biomarker development.

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  • (PMID = 20628839.001).
  • [ISSN] 1534-6307
  • [Journal-full-title] Current rheumatology reports
  • [ISO-abbreviation] Curr Rheumatol Rep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Antimetabolites; 0 / Biological Markers; 0 / Immunosuppressive Agents; 0 / Proteins; 29VT07BGDA / Citrulline; 8N3DW7272P / Cyclophosphamide; 9242ECW6R0 / mycophenolate mofetil; HU9DX48N0T / Mycophenolic Acid
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37. ||||...... 37%  Bao JP, Chen WP, Wu LD: Lubricin: a novel potential biotherapeutic approaches for the treatment of osteoarthritis. Mol Biol Rep; 2011 Jun;38(5):2879-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by escalated degeneration and loss of articular cartilage.
  • Lubrication of these surfaces is critical to normal joint function, while different gene expressions of lubricin had been found in the synovium of rheumatoid arthritis (RA) and OA.
  • Moreover, mutations or lacking of lubricin gene have been shown to link to the joint disease such as camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), synovial hyperplasia and failure of joint function, suggesting an important role of lubricin in the pathogenesis of these joint disease.
  • [MeSH-minor] Animals. Cartilage, Articular / cytology. Cartilage, Articular / metabolism. Cartilage, Articular / pathology. Chondrocytes / metabolism. Chondrocytes / pathology. Disease Progression. Humans. Joints / anatomy & histology. Joints / metabolism. Joints / pathology. Lubrication. Synovial Membrane / metabolism. Synovial Membrane / pathology

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  • (PMID = 20099082.001).
  • [ISSN] 1573-4978
  • [Journal-full-title] Molecular biology reports
  • [ISO-abbreviation] Mol. Biol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Glycoproteins; 0 / lubricin
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38. ||||...... 37%  El-Gabalawy H: The preclinical stages of RA: lessons from human studies and animal models. Best Pract Res Clin Rheumatol; 2009 Feb;23(1):49-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis (RA) is a systemic autoimmune disorder based in the synovium of peripheral joints.
  • Retrospective studies utilizing preclinical serum samples have demonstrated that RF and ACPAs are detectable in the serum of RA patients months to years before disease onset.
  • Moreover, a close association between ACPAs, smoking, and disease-predisposing HLA-DRB1 alleles has been identified, suggesting that these risk factors may converge to precipitate autoantibody-positive RA.
  • Ultimately, the availability of data from prospective studies of RA onset will allow for novel strategies that can potentially prevent disease in high-risk individuals.
  • [MeSH-major] Arthritis, Rheumatoid / immunology. Arthritis, Rheumatoid / physiopathology. Disease Models, Animal
  • [MeSH-minor] Animals. Disease Progression. Humans. Risk Factors

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  • (PMID = 19233045.001).
  • [ISSN] 1532-1770
  • [Journal-full-title] Best practice & research. Clinical rheumatology
  • [ISO-abbreviation] Best Pract Res Clin Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 66
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39. ||||...... 37%  Yigit S, Karakus N, Tasliyurt T, Kaya SU, Bozkurt N, Kisacik B: Significance of MEFV gene R202Q polymorphism in Turkish familial Mediterranean fever patients. Gene; 2012 Sep 10;506(1):43-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever and inflammation in the peritoneum, synovium, or pleura, accompanied by pain.
  • The disease is associated with mutations in the Mediterranean fever (MEFV) gene, which encodes for the pyrin protein.

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
  • (PMID = 22771921.001).
  • [ISSN] 1879-0038
  • [Journal-full-title] Gene
  • [ISO-abbreviation] Gene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Cytoskeletal Proteins; 0 / DNA Primers; 0 / marenostrin
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40. ||||...... 37%  Heiland GR, Aigner E, Dallos T, Sahinbegovic E, Krenn V, Thaler C, Weiss G, Distler JH, Datz C, Schett G, Zwerina J: Synovial immunopathology in haemochromatosis arthropathy. Ann Rheum Dis; 2010 Jun;69(6):1214-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial immunopathology in haemochromatosis arthropathy.
  • BACKGROUND: Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis.
  • OBJECTIVE: To analyse synovial tissue obtained at surgery from patients with HH arthropathy and compare it qualitatively and quantitatively with specimens from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).
  • METHODS: Synovial tissue from 15 patients with HH, 20 with RA and 39 with OA was obtained during surgery.
  • A synovitis grading system was used to determine the severity of synovial inflammation.
  • Using immunohistochemistry, synovial neovascularisation and infiltration of macrophages, neutrophils and lymphocytes were quantitatively assessed.
  • RESULTS: Synovitis in HH arthropathy largely resembles OA with mild infiltration of mononuclear cells and lymphocytes, formation of synovial microvessels and a low degree of synovial hyperplasia.
  • This finding was observed particularly in synovial tissue of HH samples with marked haemosiderin deposition.
  • DISCUSSION: The histological picture of the synovium in HH arthropathy largely resembles a process reminiscent of OA.
  • [MeSH-major] Hemochromatosis / complications. Synovial Membrane / immunology. Synovitis / etiology. Synovitis / immunology

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  • (PMID = 19933745.001).
  • [ISSN] 1468-2060
  • [Journal-full-title] Annals of the rheumatic diseases
  • [ISO-abbreviation] Ann. Rheum. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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41. ||||...... 37%  Bao JP, Chen WP, Wu LD: Visfatin: a potential therapeutic target for rheumatoid arthritis. J Int Med Res; 2009 Nov-Dec;37(6):1655-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis (RA) is usually a chronic, systemic inflammatory disorder primarily targeting the synovium and articular cartilage.
  • Methotrexate alone or in combination with conventional and/or biological disease-modifying antirheumatic drugs (DMARDs) is often used to induce remission of active disease.
  • Emerging therapies targeting specific cytokines and growth factors in the RA inflammatory cascade offer potent new means of modifying disease activity.
  • Recently, increased concentrations of adipokines, including visfatin, mainly produced by adipocytes in serum and joint synovial fluid, were found in RA patients.

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  • (PMID = 20146863.001).
  • [ISSN] 0300-0605
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Enzyme Inhibitors; EC 2.4.2.12 / Nicotinamide Phosphoribosyltransferase
  • [Number-of-references] 43
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42. ||||...... 37%  Guermazi A, Hayashi D, Eckstein F, Hunter DJ, Duryea J, Roemer FW: Imaging of osteoarthritis. Rheum Dis Clin North Am; 2013 Feb;39(1):67-105
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoarthritis (OA) is the most prevalent joint disorder in the elderly, and there is no effective treatment.
  • Imaging is essential for evaluating the synovial joint structures (including cartilage, meniscus, subchondral bone marrow and synovium) for diagnosis, prognosis, and follow-up.

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23312411.001).
  • [ISSN] 1558-3163
  • [Journal-full-title] Rheumatic diseases clinics of North America
  • [ISO-abbreviation] Rheum. Dis. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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43. ||||...... 37%  Trajkovski T, Mayne IP, Deheshi BM, Ferguson PC: Synovial chondromatosis of the shoulder: open synovectomy and insertion of osteoarticular allogaft with internal fixation to repair intraoperative glenohumeral joint instability. Am J Orthop (Belle Mead NJ); 2011 Aug;40(8):E154-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial chondromatosis of the shoulder: open synovectomy and insertion of osteoarticular allogaft with internal fixation to repair intraoperative glenohumeral joint instability.
  • Synovial chondromatosis is a rare benign disorder characterized by chondroid metaplasia with multinodular proliferation of the synovial lining of a diarthroidal joint, bursa, or tendon sheath.
  • These cartilaginous nodules may become embedded within the proliferating synovium and may extend into the surrounding soft tissues.
  • They also can detach from the synovium, where they can calcify and may present as intra-articular loose bodies.
  • In this article, we report a case of extensive synovial chondromatosis of the right shoulder and surrounding soft tissues with extensive erosion of the humeral head, discuss combined anterior and posterior surgical excision of the cartilaginous fragments, and describe insertion of an osteoarticular allograft to repair the humeral head defect and secondary anterior glenohumeral joint instability.
  • [MeSH-major] Chondromatosis, Synovial / diagnosis. Shoulder Joint / pathology. Synovial Membrane / pathology

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  • (PMID = 22016875.001).
  • [ISSN] 1934-3418
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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44. ||||...... 37%  Sharma PR, Gore SM, Schreuder FB: Bilateral trigger finger in a 7-year-old after a viral infection: case report. J Hand Surg Am; 2010 Aug;35(8):1334-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It also implies that the transient synovitis often described in children may actually occur symptomatically in tenosynovium as well as articular synovium.
  • [MeSH-major] Synovitis / complications. Synovitis / virology. Trigger Finger Disorder / etiology

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  • [Copyright] Copyright 2010. Published by Elsevier Inc.
  • (PMID = 20638198.001).
  • [ISSN] 1531-6564
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein
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45. ||||...... 37%  Marti L, Golmia R, Golmia AP, Paes AT, Guilhen DD, Moreira-Filho CA, Scheinberg M: Alterations in cytokine profile and dendritic cells subsets in peripheral blood of rheumatoid arthritis patients before and after biologic therapy. Ann N Y Acad Sci; 2009 Sep;1173:334-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic joint inflammation and continuous immune cell infiltration in the synovium.

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  • (PMID = 19758170.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Antigens, CD14; 0 / Antigens, CD3; 0 / Antirheumatic Agents; 0 / Cytokines; 0 / Immunoconjugates; 0 / Interleukin-3 Receptor alpha Subunit; 0 / Interleukin-6; 0 / Tumor Necrosis Factor-alpha; 0 / Vascular Endothelial Growth Factor A; 130068-27-8 / Interleukin-10; 7D0YB67S97 / abatacept; 82115-62-6 / Interferon-gamma
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46. ||||...... 37%  Clouet J, Vinatier C, Merceron C, Pot-vaucel M, Maugars Y, Weiss P, Grimandi G, Guicheux J: From osteoarthritis treatments to future regenerative therapies for cartilage. Drug Discov Today; 2009 Oct;14(19-20):913-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying inflammatory syndrome of the synovium in addition to alteration of the subchondral bone.
  • This review provides a global view of the physiopathology of OA, as well as non-pharmacological and pharmacological treatments for the disorder.

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  • (PMID = 19651235.001).
  • [ISSN] 1878-5832
  • [Journal-full-title] Drug discovery today
  • [ISO-abbreviation] Drug Discov. Today
  • [Language] eng
  • [Publication-type] Journal Article; Portraits; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents
  • [Number-of-references] 114
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47. ||||...... 37%  Mobasheri A, Moskaluk CA, Marples D, Shakibaei M: Expression of aquaporin 1 (AQP1) in human synovitis. Ann Anat; 2010 Apr 20;192(2):116-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial proliferation (synovitis), articular cartilage and subchondral bone degradation as well as joint swelling.
  • Clinical evidence suggests that joint swelling and edema accompany the chronic inflammation observed in synovial joints of RA patients.
  • Therefore we hypothesized that AQP1 water channels may be involved in joint swelling and synovial edema formation.
  • To test this hypothesis, we performed immunostaining of normal and human synovitis tissue microarrays (TMAs) to investigate whether the expression of AQP1 water channels is altered in the synovium in synovitis.
  • Immunohistochemistry revealed that AQP1 is expressed in synovial micro-vessels and synoviocytes from normal joints (n=20 normal subjects).
  • Semi-quantitative histomorphometric analysis of AQP1 expression in the TMAs revealed upregulation of the membrane protein in the synovium derived from RA (n=10) and psoriatic arthritis (n=8) patients.
  • These results indicate a potential role for synovial AQP1 and other aquaporins in joint swelling and the vasogenic edema fluid formation and hydrarthrosis associated with synovial inflammation.

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  • [Copyright] Copyright 2010 Elsevier GmbH. All rights reserved.
  • (PMID = 20149606.001).
  • [ISSN] 1618-0402
  • [Journal-full-title] Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • [ISO-abbreviation] Ann. Anat.
  • [Language] eng
  • [Grant] United Kingdom / Biotechnology and Biological Sciences Research Council / / ; United Kingdom / Medical Research Council / / ; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 146410-94-8 / Aquaporin 1
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48. ||||...... 37%  Bennàssar A, Mas A, Guilabert A, Julià M, Mascaró-Galy JM, Herrero C: Multicentric reticulohistiocytosis with elevated cytokine serum levels. J Dermatol; 2011 Sep;38(9):905-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a multisystem disorder characterised by a papulonodular skin eruption, mainly in the extensor surfaces, and destructive polyarthritis.
  • Histologically, either cutaneous lesions or the synovium show a dense dermal infiltrate of histiocytes and multinucleated giant cells with an eosinophilic granular material in the cytoplasm.

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  • HSDB. structure - PREDNISONE.
  • HSDB. structure - METHOTREXATE.
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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • [Copyright] © 2011 Japanese Dermatological Association.
  • (PMID = 21658110.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; VB0R961HZT / Prednisone; YL5FZ2Y5U1 / Methotrexate
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49. ||||...... 37%  Feely MG, Erickson A, O'Dell JR: Therapeutic options for rheumatoid arthritis. Expert Opin Pharmacother; 2009 Sep;10(13):2095-106
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder primarily targeting the synovium.
  • Unchecked disease activity is associated with significant morbidity and an increased mortality.
  • RESULTS/CONCLUSIONS: At present, a common strategy for the treatment of RA uses methotrexate either as monotherapy or in combination with a variety of conventional and/or biologic disease-modifying antirheumatic drugs (DMARDs), with the goal of inducing remission of active disease.
  • The choice of which agent(s) to use is based upon patient-specific criteria (activity of disease, comorbidities, patient preferences, costs etc.).
  • Emerging therapies that target specific cytokines and growth factors in the inflammatory cascade of RA offer a potent new means of modifying disease activity, but many questions regarding their use remain unanswered.

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  • HSDB. structure - METHOTREXATE.
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  • (PMID = 19606939.001).
  • [ISSN] 1744-7666
  • [Journal-full-title] Expert opinion on pharmacotherapy
  • [ISO-abbreviation] Expert Opin Pharmacother
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antirheumatic Agents; 0 / Immunosuppressive Agents; YL5FZ2Y5U1 / Methotrexate
  • [Number-of-references] 80
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50. ||||...... 37%  Kim HS, Kwon JW, Ahn JH, Chang MJ, Cho EY: Localized tenosynovial giant cell tumor in both knee joints. Skeletal Radiol; 2010 Sep;39(9):923-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tenosynovial giant cell tumor, previously called pigmented villonodular synovitis (PVNS), is a rare benign neoplastic process that may involve the synovium of the joint.
  • The disorder is usually monoarticular and only a few cases have been reported on polyarticular involvement.

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  • (PMID = 20354849.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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