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1. Biomedical articles (top 11; 2009 to 2014)
1. |||||..... 50%  de Kort EH, Vrancken SL, van Heijst AF, Binkhorst M, Cuppen MP, Brons PP: Long-term subcutaneous protein C replacement in neonatal severe protein C deficiency. Pediatrics; 2011 May;127(5):e1338-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term subcutaneous protein C replacement in neonatal severe protein C deficiency.
  • We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp.
  • Laboratory investigations revealed signs of disseminated intravascular coagulation.
  • An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen plasma, and unfractionated heparin was started.
  • On the basis of plasma protein C activity and antigen levels of 0.02 and 0.03 IU/mL, respectively, after administration of fresh-frozen plasma, a diagnosis of severe protein C deficiency was established, and therapy with intravenous protein C concentrate (Ceprotin [Baxter, Deerfield, IL]) was started.
  • During 1 year of follow-up our patient frequently had protein C activity levels at <0.25 IU/mL.
  • [MeSH-major] Protein C / therapeutic use. Protein C Deficiency / diagnosis. Protein C Deficiency / drug therapy. Purpura Fulminans / drug therapy
  • [MeSH-minor] Dose-Response Relationship, Drug. Drug Administration Schedule. Follow-Up Studies. Humans. Infant, Newborn. Infusions, Intravenous. Infusions, Subcutaneous. Long-Term Care. Male. Risk Assessment. Severity of Illness Index. Treatment Outcome


2. ||||||.... 58%  Shirahata A, Mimuro J, Takahashi H, Kitajima I, Tsuji H, Eguchi Y, Matsushita T, Kajiki M, Honda G, Sakata Y: Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation. Eur J Pediatr; 2014 Mar;173(3):303-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation.
  • Recombinant soluble human thrombomodulin (TM-α) has been shown to be useful in the treatment of disseminated intravascular coagulation (DIC) in a heparin-controlled study and has been available for clinical use in Japan since 2008.
  • However, data on its use for neonatal DIC have not been reported from any clinical studies, so efficacy and safety were analyzed in 60 neonatal DIC patients identified in post-marketing surveillance.
  • The DIC resolution rate as of the day after last administration of TM-α was 47.1 %, and the survival rate at 28 days after last administration was 76.7 %.
  • Incidences of adverse drug reactions, bleeding-related adverse drug reactions, and bleeding-related adverse events were 6.7, 6.7, and 16.7 %, respectively, with no significant differences between neonatal, pediatric (excluding neonates), and adult DIC patients.
  • CONCLUSION: This surveillance provided real-world data on the safety and effectiveness of TM-alpha in the treatment of neonatal DIC in general practice settings.

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  • (PMID = 24005342.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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3. |||||..... 55%  Naz H, Fawad A, Islam A, Shahid H, Abbasi AU: Disseminated intravascular coagulation. J Ayub Med Coll Abbottabad; 2011 Oct-Dec;23(4):111-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disseminated intravascular coagulation.
  • BACKGROUND: Disseminated Intravascular Coagulation (DIC) is a complex systemic thrombohaemorrhagic disorder characterised by widespread endothelial damage.
  • Aim of this study was to assess the prevalence of DIC in different obstetrical conditions.
  • All 40 diagnosed cases of DIC were included, and their risk factors and maternal/foetal outcome were evaluated.
  • RESULTS: Out of 4,334 obstetrical admissions, DIC was diagnosed in 40 (0.92%) patients.
  • Risk factors noted were eclampsia 28 (70%), abruptio placentae 7 (17.5%), septicaemia 3 (7.5%), pancytopenia 1 (2.5%), and 1 (2.5%) patient had DIC secondary to haemorrhagic shock due to placenta previa.
  • CONCLUSION: DIC is serious life threatening condition secondary to any underlying pathology.
  • There is spontaneous resolution of DIC after correction of pathology.
  • [MeSH-major] Disseminated Intravascular Coagulation / diagnosis. Pregnancy Complications, Hematologic / diagnosis
  • [MeSH-minor] Adult. Blood Transfusion. Delivery, Obstetric. Female. Fetal Death. Gestational Age. Gravidity. Humans. Infant Mortality. Infant, Newborn. Middle Aged. Pakistan / epidemiology. Parity. Pregnancy. Pregnancy Outcome. Prevalence. Risk Factors

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  • (PMID = 23472430.001).
  • [ISSN] 1025-9589
  • [Journal-full-title] Journal of Ayub Medical College, Abbottabad : JAMC
  • [ISO-abbreviation] J Ayub Med Coll Abbottabad
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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4. |||||..... 50%  Lin R, Zhang CM, Tan LH, Shi LP, Xiong QX, Zhang EW, Shu Q, Du LZ: [Emergency use of extracorporeal membrane oxygenation in pediatric critically ill patients]. Zhonghua Er Ke Za Zhi; 2012 Sep;50(9):649-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The underlying causes of cardiorespiratory failure were as follows: two cases with acute respiratory distress syndrome (ARDS) leading to respiratory failure, 4 with failure of weaning from cardiopulmonary bypass, 3 with fulminant myocarditis, 1 with right ventricular cardiomyopathy leading to repeated cardiac arrest, 1 with preoperative severe hypoxemia, and 1 with anaphylactic shock complicated with massive pulmonary hemorrhage and severe hypoxemia.
  • Infection was documented in 3 cases, hyperbilirubinemia in 2 cases, lower limb ischemia in 1 case, hyperglycemia in 3 cases, disseminated intravascular coagulation in 1 case, membrane lung leakage in 2 cases, systemic hemolysis in 3 cases, oxygenator failure in 2 cases and oxygenator thrombosis in one case.
  • One case survived with the right lower extremity disorder from ischemic damage.
  • [MeSH-minor] Cause of Death. Child. Child, Preschool. Critical Illness / mortality. Critical Illness / therapy. Female. Humans. Infant. Infant, Newborn. Male. Postoperative Complications / mortality. Postoperative Complications / therapy. Retrospective Studies. Survival Analysis. Thrombosis / epidemiology. Thrombosis / etiology. Treatment Outcome

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  • (PMID = 23158812.001).
  • [ISSN] 0578-1310
  • [Journal-full-title] Zhonghua er ke za zhi. Chinese journal of pediatrics
  • [ISO-abbreviation] Zhonghua Er Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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5. |||||..... 51%  Uhara H, Shiohara M, Baba A, Shiohara J, Saida T: Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis. J Am Acad Dermatol; 2009 May;60(5):869-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis.
  • We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions.
  • He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood.
  • [MeSH-minor] Down Syndrome / complications. GATA1 Transcription Factor / genetics. Humans. Infant, Newborn. Male

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  • (PMID = 19389530.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / GATA1 Transcription Factor; 0 / GATA1 protein, human
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6. |||||..... 50%  Zenciroglu A, Karagol BS, Ipek MS, Okumus N, Yarali N, Aydin M: Neonatal purpura fulminans secondary to group B streptococcal infection. Pediatr Hematol Oncol; 2010 Nov;27(8):620-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neonatal purpura fulminans secondary to group B streptococcal infection.
  • Purpura fulminans is an acute and frequently fatal disorder characterized by sudden onset of progressive cutaneous hemorrhage and necrosis due to dermal vascular thrombosis and disseminated intravascular coagulation.
  • The authors present a neonate with extensive purpura fulminans due to group B streptoccoccal septicemia and evaluated the attributable clinical mortality and morbidity of this potentially lethal syndrome.
  • Clinicians especially neonatologists should be aware that early-onset sepsis of group B Streptococcus in the newborn infant with purpura fulminans could be a cause of maternal carriage due to colonization of this pathogen microorganism.
  • [MeSH-major] Necrosis / diagnosis. Purpura Fulminans / diagnosis. Streptococcal Infections / diagnosis
  • [MeSH-minor] Anti-Bacterial Agents / therapeutic use. Follow-Up Studies. Heparin / administration & dosage. Heparin / therapeutic use. Humans. Infant, Newborn. Magnetic Resonance Imaging. Male

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  • (PMID = 20795772.001).
  • [ISSN] 1521-0669
  • [Journal-full-title] Pediatric hematology and oncology
  • [ISO-abbreviation] Pediatr Hematol Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 9005-49-6 / Heparin
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7. |||||..... 53%  Rattray DD, O'Connell CM, Baskett TF: Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009). J Obstet Gynaecol Can; 2012 Apr;34(4):341-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009).
  • OBJECTIVE: To determine the antecedent factors, morbidity, and mortality associated with disseminated intravascular coagulation (DIC) in a Nova Scotia tertiary maternity hospital over a 30-year period.
  • METHODS: Cases of DIC were identified from the Nova Scotia Atlee Perinatal Database for the years 1980 to 2009 and the hospital charts reviewed.
  • The clinical diagnosis of DIC was confirmed or refuted using a combination of the International Society of Thrombosis and Haemostasis scoring system and an obstetrical DIC-severity staging system.
  • The cause of DIC was determined from chart review.
  • Neonatal outcomes included Apgar scores, birth weight, NICU admission, and death.
  • Treatment of DIC was assessed by blood products administered, postpartum hemorrhage management, and laboratory measurements.
  • RESULTS: There were 49 cases of DIC in 151 678 deliveries (3 per 10,000) over the 30 years.
  • The perinatal outcomes included stillbirth (25%), neonatal death (5%), and NICU admission (72.5%).
  • CONCLUSION: Obstetrical DIC is an uncommon condition associated with high maternal and perinatal morbidity and mortality.
  • Prompt recognition and treatment with timely administration of blood products is crucial in the management of this life-threatening disorder.
  • [MeSH-major] Disseminated Intravascular Coagulation. Pregnancy Complications. Pregnancy Outcome
  • [MeSH-minor] Abruptio Placentae. Adult. Blood Transfusion. Female. Hospitals, Maternity. Humans. Infant Mortality. Infant, Newborn. Maternal Mortality. Nova Scotia / epidemiology. Postpartum Hemorrhage. Pre-Eclampsia. Pregnancy

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  • (PMID = 22472333.001).
  • [ISSN] 1701-2163
  • [Journal-full-title] Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
  • [ISO-abbreviation] J Obstet Gynaecol Can
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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8. ||||...... 40%  Ivanov D, Shabalov N, Petrenko Y, Shabalova N, Treskina NA: The specific characteristics of DIC syndrome vary with different clinical settings in the newborn. J Matern Fetal Neonatal Med; 2014 Jul;27(11):1088-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The specific characteristics of DIC syndrome vary with different clinical settings in the newborn.
  • Abstract Two hundred fourteen newborns with serious perinatal pathology (posthypoxic syndrome, sepsis, surgical intervention, etc.) were examined in progress, according to 27 parameters including coagulative, trombocitic, anti-coagulative and fibrinolitic parts of hemostasis system.
  • It was proved, that neonatal disseminated intravascular coagulation (DIC) syndrome had different hemostasiological patterns, which were connected with the genesis: sepsis, surgical intervention or posthypoxic syndrome.
  • Precise periods of DIC syndrome are not always presented in newborns.
  • DIC syndrome with neonatal sepsis has two different patterns (overcompensated and decompensated).
  • The manifestation of trombo-hemorrhagic disorders and their characteristics depend on the genesis of DIC syndrome (e.g. an infection process and hyperbilirubinemia can provide the appearance of hemorrhagic syndrome).

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  • (PMID = 24087921.001).
  • [ISSN] 1476-4954
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; DIC syndrome / SIRS (systemic inflammatory response syndrome) / hemostasis / newborns / posthypoxic
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9. ||||...... 35%  Jain R, T L, Chandran J, Jayandharan GR, Palle A, Moses PD: A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans. Blood Coagul Fibrinolysis; 2013 Dec;24(8):890-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A novel mutation c.1048A>T at codon 350(Lys>Stop) in PROC gene causing neonatal purpura fulminans.
  • Purpura fulminans in the neonatal period due to severe congenital protein C deficiency (protein C activity <1 IU/dl) is a rare autosomal recessive disorder.
  • Acquired deficiency of protein C caused by increased consumption as overt disseminated intravascular coagulation (DIC) and severe infection creates a diagnostic dilemma.
  • Mutation analysis plays a critical role in confirming the diagnosis of the disease and offering prenatal diagnosis.
  • In this report, we describe a newborn who presented with purpura fulminans and DIC, molecular analysis showed a novel c.1048A>T transversion in a homozygous state at codon 350 (Lys>Stop) of protein C (PROC) gene.
  • Prenatal diagnosis in subsequent pregnancy was done which revealed the affected fetus had the same mutation in homozygous form.
  • [MeSH-major] Disseminated Intravascular Coagulation / pathology. Protein C / genetics. Purpura Fulminans / pathology
  • [MeSH-minor] Consanguinity. Fatal Outcome. Female. Homozygote. Humans. Infant, Newborn. Point Mutation. Pregnancy

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  • (PMID = 24158118.001).
  • [ISSN] 1473-5733
  • [Journal-full-title] Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
  • [ISO-abbreviation] Blood Coagul. Fibrinolysis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein C
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10. |......... 8%  Shirahata A, Mimuro J, Takahashi H, Kitajima I, Tsuji H, Eguchi Y, Matsushita T, Kajiki M, Honda G, Sakata Y: Erratum to: Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation. Eur J Pediatr; 2014 Oct;173(10):1405-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Erratum to: Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation.

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  • (PMID = 25066772.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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11. |......... 1%  Vanrykel K, Bruneel E, Van Hoestenberghe MR, Buekenhout L, Gyselaers W, Theyskens C: Neonatal disseminated intravascular coagulation after thrombosis of a fetal intra-abdominal umbilical vein varix. J Obstet Gynaecol; 2010 Apr;30(3):315
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neonatal disseminated intravascular coagulation after thrombosis of a fetal intra-abdominal umbilical vein varix.
  • [MeSH-major] Disseminated Intravascular Coagulation / etiology. Fetal Diseases / ultrasonography. Umbilical Veins / pathology. Varicose Veins / complications. Venous Thrombosis / complications
  • [MeSH-minor] Dilatation, Pathologic. Female. Humans. Infant, Newborn. Male. Pregnancy. Ultrasonography, Prenatal


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2. Definitions


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