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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 50%  Goldring SR: Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis. Ther Adv Musculoskelet Dis; 2012 Aug;4(4):249-58
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis.
  • The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint.
  • Given the intimate contact between the cartilage and bone, alterations of either tissue will modulate the properties and function of the other joint component.
  • The changes in periarticular bone tend to occur very early in the development of OA.
  • Although chondrocytes also have the capacity to modulate their functional state in response to loading, the capacity of these cells to repair and modify their surrounding extracellular matrix is relatively limited in comparison to the adjacent subchondral bone.
  • This differential adaptive capacity likely underlies the more rapid appearance of detectable skeletal changes in OA in comparison to the articular cartilage.
  • The OA changes in periarticular bone include increases in subchondral cortical bone thickness, gradual decreases in subchondral trabeular bone mass, formation of marginal joint osteophytes, development of bone cysts and advancement of the zone of calcified cartilage between the articular cartilage and subchondral bone.
  • The expansion of the zone of calcified cartilage contributes to overall thinning of the articular cartilage.
  • The mechanisms involved in this process include the release of soluble mediators from chondrocytes in the deep zones of the articular cartilage and/or the influences of microcracks that have initiated focal remodeling in the calcified cartilage and subchondral bone in an attempt to repair the microdamage.
  • There is the need for further studies to define the pathophysiological mechanisms involved in the interaction between subchondral bone and articular cartilage and for applying this information to the development of therapeutic interventions to improve the outcomes in patients with OA.

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  • (PMID = 22859924.001).
  • [ISSN] 1759-7218
  • [Journal-full-title] Therapeutic advances in musculoskeletal disease
  • [ISO-abbreviation] Ther Adv Musculoskelet Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3403248
  • [Keywords] NOTNLM ; articular cartilage / biomechanics / bone remodeling / osteoarthritis
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2. |||||..... 46%  Mobasheri A: Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator. Front Endocrinol (Lausanne); 2012;3:153
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  • [Title] Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator.
  • In the skeletal system glucose serves as an essential source of energy for the development, growth, and maintenance of bone and articular cartilage.
  • Skeletal muscle and adipose tissue can respond to changes in circulating glucose but much less is known about glucosensing in bone and cartilage.
  • Recent research suggests that bone cells can influence (and be influenced by) systemic glucose metabolism.
  • This focused review article discusses what we know about glucose transport and metabolism in bone and cartilage and highlights recent studies that have linked glucose metabolism, insulin signaling, and osteocalcin activity in bone.
  • These new findings in bone cells raise important questions about nutrient sensing, uptake, storage and processing mechanisms and how they might contribute to overall energy homeostasis in health and disease.
  • In summary, cartilage and bone cells are sensitive to extracellular glucose and adjust their gene expression and metabolism in response to varying extracellular glucose concentrations.

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  • (PMID = 23251132.001).
  • [ISSN] 1664-2392
  • [Journal-full-title] Frontiers in endocrinology
  • [ISO-abbreviation] Front Endocrinol (Lausanne)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3523231
  • [Keywords] NOTNLM ; articular cartilage / bone / extracellular signaling / glucose / glucose transport / glucosensing / hexokinase / osteocalcin
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3. |||....... 29%  Pinney JR, Taylor C, Doan R, Burghardt AJ, Li X, Kim HT, Benjamin Ma C, Majumdar S: Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis. Magn Reson Imaging; 2012 Feb;30(2):271-82
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  • [Title] Imaging longitudinal changes in articular cartilage and bone following doxycycline treatment in a rabbit anterior cruciate ligament transection model of osteoarthritis.
  • T(1ρ) and T(2) mapping techniques have the ability to provide highly accurate and quantitative measurements of articular cartilage degeneration in vivo.
  • Relating these cartilaginous changes to high-resolution bone-densitometric evaluations of the late-stage osteoarthritic bone is crucial in elucidating the mechanisms of development of traumatic osteoarthritis (OA) and potential therapies for early- or late-stage intervention.
  • This biphasic pattern could hold diagnostic potential to differentiate osteoarthritic cartilage by tracking the relative proportions of T(1ρ) and T(2) values as they rise with inflammation then fall as collagen and proteoglycan loss leads to further dehydration.
  • Micro-CT studies demonstrated decreased bone densitometrics in ACL-transected knees.
  • In addition, doxycycline may show promise in mitigating early-stage cartilage damage that may serve to lessen late-stage osteoarthritic changes.
  • [MeSH-major] Bone and Bones / pathology. Cartilage, Articular / pathology. Disease Models, Animal. Doxycycline / administration & dosage. Magnetic Resonance Imaging / methods. Osteoarthritis / drug therapy. Osteoarthritis / pathology

  • MedlinePlus Health Information. consumer health - MRI Scans.
  • MedlinePlus Health Information. consumer health - Osteoarthritis.
  • HSDB. structure - DOXYCYCLINE.
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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
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  • (PMID = 22071411.001).
  • [ISSN] 1873-5894
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Grant] United States / NIA NIH HHS / AG / R01 AG017762-03; United States / NIA NIH HHS / AG / R01 AG17762; United States / NIGMS NIH HHS / GM / T32 GM007618
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Immunosuppressive Agents; N12000U13O / Doxycycline
  • [Other-IDs] NLM/ NIHMS330045; NLM/ PMC3307548
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4. |||....... 26%  Rowas SA, Haddad R, Gawri R, Al Ma'awi AA, Chalifour LE, Antoniou J, Mwale F: Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise. Arthritis Res Ther; 2012;14(1):R17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise.
  • The aim of this study was to determine the effects of diethylstilbestrol (DES), a well-known estrogen agonist, on articular cartilage, intervertebral disc (IVD), and bone phenotype.
  • METHODS: C57Bl/6 pregnant mice were dosed orally with vehicle (peanut oil) or 0.1, 1.0, and 10 μg/kg/day of DES on gestational days 11 to 14.
  • After euthanasia, bone mineral density (BMD), bone mineral content (BMC), bone area (BA), and trabecular bone area (TBA) of the lumbar vertebrae and femur were measured by using a PIXImus Bone Densitometer System.
  • Histologic analysis of proteoglycan for IVD and articular cartilage was performed with safranin O staining, and degeneration parameters were scored.
  • RESULTS: The lumbar BMC was significantly increased in female swimmers at both the highest and lowest dose of DES, whereas the femoral BMC was increased only at the highest.
  • The males, conversely, showed a decreased BMC at the highest dose of DES for both lumbar and femoral bone.
  • The female swim group had an increased BA at the highest dose of DES, whereas the male counterpart showed a decreased BA for femoral bone.
  • Histologic examination showed morphologic changes of the IVD and articular cartilage for all doses of DES.
  • CONCLUSIONS: DES significantly affected the musculoskeletal system of adult mice.
  • Results suggest that environmental estrogen contaminants can have a detrimental effect on the developmental lumbar bone growth and mineralization in mice.
  • [MeSH-major] Bone and Bones / drug effects. Cartilage, Articular / drug effects. Diethylstilbestrol / toxicity. Prenatal Exposure Delayed Effects / physiopathology. Swimming / physiology
  • [MeSH-minor] Administration, Oral. Animals. Bone Density / drug effects. Dose-Response Relationship, Drug. Estrogens, Non-Steroidal / toxicity. Female. Femur / drug effects. Femur / metabolism. Femur / pathology. Intervertebral Disc / drug effects. Intervertebral Disc / metabolism. Intervertebral Disc / pathology. Lumbar Vertebrae / drug effects. Lumbar Vertebrae / metabolism. Lumbar Vertebrae / pathology. Male. Mice. Mice, Inbred C57BL. Pregnancy. Proteoglycans / metabolism. Time Factors. X-Ray Microtomography

  • HSDB. structure - DIETHYLSTILBESTROL.
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  • (PMID = 22269139.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Estrogens, Non-Steroidal; 0 / Proteoglycans; 731DCA35BT / Diethylstilbestrol
  • [Other-IDs] NLM/ PMC3392807
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5. ||........ 23%  Gomoll AH, Madry H, Knutsen G, van Dijk N, Seil R, Brittberg M, Kon E: The subchondral bone in articular cartilage repair: current problems in the surgical management. Knee Surg Sports Traumatol Arthrosc; 2010 Apr;18(4):434-47
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The subchondral bone in articular cartilage repair: current problems in the surgical management.
  • As the understanding of interactions between articular cartilage and subchondral bone continues to evolve, increased attention is being directed at treatment options for the entire osteochondral unit, rather than focusing on the articular surface only.
  • Also discussed are surgical techniques designed to address these issues, including the use of osteochondral allografts, autologous bone grafting, next generation cell-based implants, as well as strategies after failed subchondral repair and problems specific to the ankle joint.
  • [MeSH-major] Ankle Joint / surgery. Bone Marrow Transplantation / methods. Bone and Bones / surgery. Cartilage, Articular / surgery

  • MedlinePlus Health Information. consumer health - Bone Marrow Transplantation.
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  • (PMID = 20130833.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 85
  • [Other-IDs] NLM/ PMC2839476
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6. ||........ 22%  Pan J, Zhou X, Li W, Novotny JE, Doty SB, Wang L: In situ measurement of transport between subchondral bone and articular cartilage. J Orthop Res; 2009 Oct;27(10):1347-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] In situ measurement of transport between subchondral bone and articular cartilage.
  • Subchondral bone and articular cartilage play complementary roles in load bearing of the joints.
  • Although the biomechanical coupling between subchondral bone and articular cartilage is well established, it remains unclear whether direct biochemical communication exists between them.
  • Previously, the calcified cartilage between these two compartments was generally believed to be impermeable to transport of solutes and gases.
  • However, recent studies found that small molecules could penetrate into the calcified cartilage from the subchondral bone.
  • To quantify the real-time solute transport across the calcified cartilage, we developed a novel imaging method based on fluorescence loss induced by photobleaching (FLIP).
  • Diffusivity of sodium fluorescein (376 Da) was quantified to be 0.07 +/- 0.03 and 0.26 +/- 0.22 microm(2)/s between subchondral bone and calcified cartilage and within the calcified cartilage in the murine distal femur, respectively.
  • Electron microscopy revealed that calcified cartilage matrix contained nonmineralized regions (approximately 22% volume fraction) that are either large patches (53 +/- 18 nm) among the mineral deposits or numerous small regions (4.5 +/- 0.8 nm) within the mineral deposits, which may serve as transport pathways.
  • These results suggest that there exists a possible direct signaling between subchondral bone and articular cartilage, and they form a functional unit with both mechanical and biochemical interactions, which may play a role in the maintenance and degeneration of the joint.
  • [MeSH-major] Cartilage, Articular / metabolism. Femur / metabolism. Joints / metabolism

  • HSDB. structure - FLUORESCEIN.
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  • [Copyright] (c) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
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  • (PMID = 19360842.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016458-076332; United States / NCRR NIH HHS / RR / P20RR016458; United States / NIAMS NIH HHS / AR / R01 AR054385-02; United States / NIAMS NIH HHS / AR / R01AR054385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 2321-07-5 / Fluorescein
  • [Other-IDs] NLM/ NIHMS129979; NLM/ PMC2748158
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7. ||||...... 45%  Baur A, Henkel J, Bloch W, Treiber N, Scharffetter-Kochanek K, Brüggemann GP, Niehoff A: Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase (SOD2) deficient mice. Free Radic Res; 2011 May;45(5):550-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase (SOD2) deficient mice.
  • Reactive oxygen species (ROS) are involved in both bone and cartilage physiology and play an important role in the pathogenesis of osteoporosis and osteoarthritis.
  • The present study investigated the effect of running exercise on bone and cartilage in heterozygous manganese superoxide dismutase (SOD2)-deficient mice.
  • Heterozygous SOD2-deficient mice should exhibit an impaired capability to compensate, resulting in an increased oxidative stress in cartilage and bone.
  • In SOD2(+/-) mice elevated levels of 15-F(2t)-isoprostane and nitrotyrosine were detected in bone and articular cartilage compared to wild type littermates.
  • These results demonstrate that exercise might protect bone against oxidative stress in heterozygous SOD2-deficient mice.
  • [MeSH-major] Bone and Bones / metabolism. Cartilage, Articular / cytology. Cartilage, Articular / metabolism. Dinoprost / analogs & derivatives. Physical Conditioning, Animal. Superoxide Dismutase / deficiency. Tyrosine / analogs & derivatives

  • HSDB. structure - PROSTAGLANDIN F2ALPHA.
  • HSDB. structure - L-TYROSINE.
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  • (PMID = 21291351.001).
  • [ISSN] 1029-2470
  • [Journal-full-title] Free radical research
  • [ISO-abbreviation] Free Radic. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reactive Oxygen Species; 27415-26-5 / 8-epi-prostaglandin F2alpha; 3604-79-3 / 3-nitrotyrosine; 42HK56048U / Tyrosine; B7IN85G1HY / Dinoprost; EC 1.15.1.1 / Superoxide Dismutase
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8. ||........ 24%  Menetrey J, Unno-Veith F, Madry H, Van Breuseghem I: Epidemiology and imaging of the subchondral bone in articular cartilage repair. Knee Surg Sports Traumatol Arthrosc; 2010 Apr;18(4):463-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidemiology and imaging of the subchondral bone in articular cartilage repair.
  • Articular cartilage and the subchondral bone act as a functional unit.
  • Osteochondral defects-the type of defects that extend into the subchondral bone-account for about 5% of all articular cartilage lesions.
  • Because of the close relationship between the articular cartilage and the subchondral bone, imaging of cartilage defects or cartilage repair should also focus on the subchondral bone.
  • Magnetic resonance imaging is currently considered to be the key modality for the evaluation of cartilage and underlying subchondral bone.
  • However, the choice of imaging technique also depends on the nature of the disease that caused the subchondral bone lesion.
  • Bone scintigraphy is one of the most valuable techniques for early diagnosis of spontaneous osteonecrosis about the knee.
  • A CT scan is a useful technique to rule out a possible depression of the subchondral bone plate, whereas a CT arthrography is highly accurate to evaluate the stability of the osteochondral fragment in osteochondritis dissecans.
  • Particularly for the problem of subchondral bone lesions, image evaluation methods need to be refined for adequate and reproducible analysis.
  • This article highlights recent studies on the epidemiology and imaging of the subchondral bone, with an emphasis on magnetic resonance imaging.
  • [MeSH-major] Bone Transplantation / methods. Bone and Bones / injuries. Cartilage, Articular / injuries. Chondrocytes / transplantation

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  • (PMID = 20148327.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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9. ||........ 22%  Fedorov AA, Riabko EV, Gromov AS: [The use of magnetic-laser therapy in the combined treatment of osteoarthrosis in workers exposed to inorganic fluoride compounds]. Vopr Kurortol Fizioter Lech Fiz Kult; 2010 Jul-Aug;(4):20-2
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  • Simultaneously, metabolic processes in the articular cartilage and bone tissue were normalized, lipid peroxidation was improved and optimization of antioxidative protection achieved.

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  • (PMID = 21086591.001).
  • [ISSN] 0042-8787
  • [Journal-full-title] Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury
  • [ISO-abbreviation] Vopr Kurortol Fizioter Lech Fiz Kult
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Randomized Controlled Trial
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Air Pollutants, Occupational; Q80VPU408O / Fluorides
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10. ||........ 22%  Xia LP, Xiao WG, Li JS, Ding S, Lu J: [Effects of TWEAK on the synthesis of MMP-3 in fibroblast-like synoviocytes of rheumatoid arthritis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2009 Jan;25(1):46-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To investigate the effects of TWEAK on the synthesis of MMP-3 in RA FLS at different concentrations and to discuss the relative mechanism of how TWEAK involves in the destruction of articular bone and cartilage.
  • CONCLUSION: TWEAK can induce RA FLS to synthesize MMP-3 and damage the articular bone and cartilage directly.

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  • (PMID = 19126387.001).
  • [ISSN] 1007-8738
  • [Journal-full-title] Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
  • [ISO-abbreviation] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / TNFSF12 protein, human; 0 / Tumor Necrosis Factors; EC 3.4.24.17 / Matrix Metalloproteinase 3
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11. ||........ 21%  Iversen MD: Rehabilitation interventions for pain and disability in osteoarthritis. Am J Nurs; 2012 Mar;112(3 Suppl 1):S32-7
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  • Osteoarthritis (OA) results in progressive destruction of articular cartilage and bone at the joint margins, leading to impairments extending far beyond the synovial joint.

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  • [ReprintIn] Orthop Nurs. 2012 Mar-Apr;31(2):103-8 [22446803.001]
  • (PMID = 22373745.001).
  • [ISSN] 1538-7488
  • [Journal-full-title] The American journal of nursing
  • [ISO-abbreviation] Am J Nurs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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12. ||........ 21%  Niedermeier M, Pap T, Korb A: Therapeutic opportunities in fibroblasts in inflammatory arthritis. Best Pract Res Clin Rheumatol; 2010 Aug;24(4):527-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • These cells have been demonstrated to trigger not only the progressive destruction of articular cartilage and bone but also the switch from acute to chronic inflammation.

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20732650.001).
  • [ISSN] 1532-1770
  • [Journal-full-title] Best practice & research. Clinical rheumatology
  • [ISO-abbreviation] Best Pract Res Clin Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Cell Adhesion Molecules; 0 / Cytokines
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13. ||........ 21%  Li D, Yuan Q, Wang W: The role of telomeres in musculoskeletal diseases. J Int Med Res; 2012;40(4):1242-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Studies of articular cartilage and bone tissues have indicated that telomere shortening limits normal cell function and proliferation, while the telomere maintenance mechanisms of osteosarcoma cells facilitate escape from cell death and promote immortality.
  • [MeSH-major] Bone Neoplasms / genetics. Osteoarthritis / genetics. Osteoporosis / genetics. Osteosarcoma / genetics. Telomere / genetics

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  • (PMID = 22971476.001).
  • [ISSN] 1473-2300
  • [Journal-full-title] The Journal of international medical research
  • [ISO-abbreviation] J. Int. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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14. ||........ 21%  Iversen MD: Rehabilitation interventions for pain and disability in osteoarthritis: a review of interventions including exercise, manual techniques, and assistive devices. Orthop Nurs; 2012 Mar-Apr;31(2):103-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OVERVIEW: Osteoarthritis (OA) results in progressive destruction of articular cartilage and bone at the joint margins, leading to impairments extending far beyond the synovial joint.

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  • [ReprintOf] Am J Nurs. 2012 Mar;112(3 Suppl 1):S32-7 [22373745.001]
  • (PMID = 22446803.001).
  • [ISSN] 1542-538X
  • [Journal-full-title] Orthopaedic nursing / National Association of Orthopaedic Nurses
  • [ISO-abbreviation] Orthop Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. ||........ 20%  Choi EM, Suh KS: Ligularia fischeri leaf extract suppresses proinflammatory mediators in SW982 human synovial cells. Phytother Res; 2009 Nov;23(11):1575-80
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  • Synovial hyperplasia is a hallmark of rheumatoid arthritis (RA) and is regarded as a major destructive element of articular bone and cartilage.

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  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 19370536.001).
  • [ISSN] 1099-1573
  • [Journal-full-title] Phytotherapy research : PTR
  • [ISO-abbreviation] Phytother Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Interleukin-6; 0 / NF-kappa B; 0 / Plant Extracts; 0 / Transcription Factor AP-1; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24 / p38 Mitogen-Activated Protein Kinases; EC 3.4.24.17 / MMP3 protein, human; EC 3.4.24.17 / Matrix Metalloproteinase 3
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16. ||........ 20%  Biedert R, Sigg A, Gal I, Gerber H: 3D representation of the surface topography of normal and dysplastic trochlea using MRI. Knee; 2011 Oct;18(5):340-6
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  • The three-dimensional (3D) image of the articular surface topography of the normal and the dysplastic trochlea has not been defined.
  • Using the segmentation software program Amira (Mercury Computer Systems, Inc., Chelmsford, USA) we created 3D reconstructions of the distal femur bone and cartilage using MRI scans.
  • Bone and cartilage of the distal femur were traced slice by slice in the acquisitioned dimension while the Amira program reconstructed the 3D model.
  • Using this system a non-invasive 3D representation of the articular cartilage and bone of the normal trochlea and depiction of different types of trochlear dysplasia were possible.
  • Potential advantages of these MRI measurements are assessment of the 3D articular cartilage of the whole trochlea and the bony contours on the same image, no imaging errors from joint malpositioning, no ionizing radiation, precise preoperative planning according to the documented pathomorphology, and comparison between the preoperative and the postoperative shapes.
  • [MeSH-major] Bone Diseases, Developmental / diagnosis. Femur / abnormalities. Knee Joint / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Cartilage, Articular / pathology. Humans. Image Processing, Computer-Assisted. Imaging, Three-Dimensional. Joint Instability / diagnosis. Patella / pathology

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  • [Copyright] Copyright © 2010 Elsevier B.V. All rights reserved.
  • (PMID = 20719521.001).
  • [ISSN] 1873-5800
  • [Journal-full-title] The Knee
  • [ISO-abbreviation] Knee
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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17. ||........ 20%  Zheng B, Li G, Chen WC, Deasy BM, Pollett JB, Sun B, Drowley L, Gharaibeh B, Usas A, Péault B, Huard J: Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level. J Orthop Res; 2013 Jul;31(7):1089-95
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  • MEC clones were capable of differentiating into chondrocytes and osteoblasts under inductive conditions in vitro and participated in cartilage and bone formation in vivo.
  • Overall, our study showed that cMECs not only display typical properties of adult stem cells but also exhibit chondrogenic and osteogenic capacities in vitro and in vivo, suggesting their potential applications in articular cartilage and bone repair/regeneration.

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  • [Copyright] Copyright © 2013 Orthopaedic Research Society.
  • (PMID = 23553740.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Grant] United Kingdom / Medical Research Council / / G1000816; United States / NIAMS NIH HHS / AR / IU54AR050733-01; United States / NIAMS NIH HHS / AR / R01-AR049684; United States / NIDCR NIH HHS / DE / R01-DE13420-06
  • [Publication-type] In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
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18. ||........ 20%  Korb A, Pavenstädt H, Pap T: Cell death in rheumatoid arthritis. Apoptosis; 2009 Apr;14(4):447-54
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  • As a result, a hyperplastic synovial tissue is generated that mediates the progressive destruction of articular cartilage and bone.
  • Once activated, these cells pass through prominent molecular changes resulting in an aggressive, invasive behaviour.

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  • (PMID = 19199037.001).
  • [ISSN] 1573-675X
  • [Journal-full-title] Apoptosis : an international journal on programmed cell death
  • [ISO-abbreviation] Apoptosis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / SUMO-1 Protein; 0 / TNF-Related Apoptosis-Inducing Ligand; 0 / TNFSF10 protein, human
  • [Number-of-references] 56
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19. ||........ 20%  Vinatier C, Bordenave L, Guicheux J, Amédée J: [Stem cells for osteoarticular and vascular tissue engineering]. Med Sci (Paris); 2011 Mar;27(3):289-96
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  • [Transliterated title] Les cellules souches en ingénierie des tissus ostéoarticulaires et vasculaires.
  • Articular cartilage, bone and blood vessels are tissues for which TE has progressed significantly, from basic research to clinical trials.
  • If biomaterials must exhibit different properties depending on the tissue to regenerate, the cellular component of TE is mostly represented by stem cells notably adult mesenchymal stem cells harvested from bone marrow or adipose tissue.
  • [MeSH-major] Blood Vessels. Bone and Bones. Cartilage, Articular. Stem Cells. Tissue Engineering / methods

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  • [Copyright] © 2011 médecine/sciences - Inserm / SRMS.
  • (PMID = 21447302.001).
  • [ISSN] 0767-0974
  • [Journal-full-title] Médecine sciences : M/S
  • [ISO-abbreviation] Med Sci (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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20. ||........ 20%  Pang Z, Wei Q, Zhou G, Chen P, He W, Bai B, Li Y: [Establishment and application of subject-specific three-dimensional finite element mesh model for osteonecrosis of femoral head]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi; 2012 Apr;29(2):251-5
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  • A highly geometric similar subject-specific 3D finite element mesh model for osteonecrosis of femoral head has been established, which included normal cortical bone, cancellous bone, articular cartilage and necrotic zone, fractured trabecular bone within the femoral head.

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  • (PMID = 22616168.001).
  • [ISSN] 1001-5515
  • [Journal-full-title] Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
  • [ISO-abbreviation] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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21. ||........ 20%  Bain GI, Galley IJ, Singh C, Carter C, Eng K: Anatomic study of the superior glenoid labrum. Clin Anat; 2013 Apr;26(3):367-76
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  • Twenty dry bone scapulae and 19 cadaveric shoulders were examined.
  • A separate internal labral circumferential ridge 4 mm central to the glenoid rim marks the interface between the labrum and articular cartilage.
  • The superior labrum is concave and is loosely attached to the articular cartilage and glenoid rim.
  • In contrast the anterior-inferior labrum is convex, attaches 4 mm central to the glenoid rim and has a strong attachment to articular cartilage and bone.

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 23001615.001).
  • [ISSN] 1098-2353
  • [Journal-full-title] Clinical anatomy (New York, N.Y.)
  • [ISO-abbreviation] Clin Anat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. ||........ 20%  Dobrowolski P, Tomaszewska E, Bienko M, Radzki RP, Pierzynowski SG: The effect of dietary administration of 2-oxoglutaric acid on the cartilage and bone of growing rats. Br J Nutr; 2013 Aug;110(4):651-8
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  • [Title] The effect of dietary administration of 2-oxoglutaric acid on the cartilage and bone of growing rats.
  • 2-Oxoglutaric acid (2-Ox), a precursor to hydroxyproline - the most abundant amino acid in bone collagen, exerts protective effects on bone development during different stages of organism development; however, little is known about the action of 2-Ox on cartilage.
  • The aim of the present study was to elucidate the influence of dietary 2-Ox supplementation on the growth plate, articular cartilage and bone of growing rats.
  • Histomorphometric analyses of the cartilage and bone tissue of the femora and tibiae were conducted, as well as bone densitometry and peripheral quantitative computed tomography (pQCT).
  • Femoral length (P=0·045) and bone mineral density (P=0·014), overall thickness of growth plate (femur P=0·036 and tibia P=0·026) and the thickness of femoral articular cartilage (P<0·001) were also increased.
  • There were also no significant differences in histomorphometric parameters of tibial articular cartilage and autofluorescence of femoral and tibial growth plate cartilage.
  • Dietary supplementation with 2-Ox to growing rats exerts its effects mainly on cartilage tissue, having only a slight influence on bone.
  • The effect of 2-Ox administration was selective, depending on the particular bone and type of cartilage analysed.
  • [MeSH-major] Cartilage / drug effects. Growth Plate / drug effects. Ketoglutaric Acids / administration & dosage
  • [MeSH-minor] Animals. Body Mass Index. Body Weight. Bone Density. Dietary Supplements. Dose-Response Relationship, Drug. Femur / drug effects. Male. Models, Animal. Organ Size / drug effects. Rats. Rats, Sprague-Dawley. Stress, Mechanical. Tibia / drug effects

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  • (PMID = 23308390.001).
  • [ISSN] 1475-2662
  • [Journal-full-title] The British journal of nutrition
  • [ISO-abbreviation] Br. J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Ketoglutaric Acids; 328-50-7 / alpha-ketoglutaric acid
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23. ||........ 20%  Multanen J, Nieminen MT, Häkkinen A, Kujala UM, Jämsä T, Kautiainen H, Lammentausta E, Ahola R, Selänne H, Ojala R, Kiviranta I, Heinonen A: Effects of high-impact training on bone and articular cartilage: 12-month randomized controlled quantitative MRI study. J Bone Miner Res; 2014 Jan;29(1):192-201
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  • [Title] Effects of high-impact training on bone and articular cartilage: 12-month randomized controlled quantitative MRI study.
  • The simultaneous effect of bone-favorable high-impact training on these diseases is not well understood and is a topic of controversy.
  • We evaluated the effects of high-impact exercise on bone mineral content (BMC) and the estimated biochemical composition of knee cartilage in postmenopausal women with mild knee osteoarthritis.
  • The biochemical composition of cartilage was estimated using delayed gadolinium-enhanced magnetic resonance imaging (MRI) cartilage (dGEMRIC), sensitive to cartilage glycosaminoglycan content, and transverse relaxation time (T2) mapping that is sensitive to the properties of the collagen network.
  • The change in baseline, body mass, and adjusted body mass change in BMC between the groups was significant (p = 0.005), whereas no changes occurred in the biochemical composition of the cartilage, as investigated by MRI.
  • Progressively implemented high-impact training, which increased bone mass, did not affect the biochemical composition of cartilage and may be feasible in the prevention of osteoporosis and physical performance-related risk factors of falling in postmenopausal women.

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  • [Copyright] © 2014 American Society for Bone and Mineral Research.
  • (PMID = 23775755.001).
  • [ISSN] 1523-4681
  • [Journal-full-title] Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • [ISO-abbreviation] J. Bone Miner. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Keywords] NOTNLM ; EXERCISE / MENOPAUSE / OSTEOARTHRITIS / OSTEOPOROSIS / RADIOLOGY
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24. ||........ 20%  Wilby MJ, Fraser RD, Vernon-Roberts B, Moore RJ: The prevalence and pathogenesis of synovial cysts within the ligamentum flavum in patients with lumbar spinal stenosis and radiculopathy. Spine (Phila Pa 1976); 2009 Nov 1;34(23):2518-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • LF/facet joint (FJ) relationships were retained by en bloc excision of the LF and the medial inferior FJ.
  • Fragments of articular cartilage and bone were embedded in the walls of 89% of cysts and in the walls of a bursa-like channel originating from the medial aspect of the FJ capsule and extending into the LF.
  • Advanced osteoarthritis of the FJ causes the liberation of fragments of cartilage and bone into the synovial fluid of the joint space.
  • The tissue response to articular debris may block the synovial-lined channel to cause synovial cyst formation.

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  • (PMID = 19927101.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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25. ||........ 20%  Isaac C, Wright A, Usas A, Li H, Tang Y, Mu X, Greco N, Dong Q, Vo N, Kang J, Wang B, Huard J: Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities. J Orthop Res; 2013 Mar;31(3):343-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by the lack of dystrophin expression at the sarcolemma of muscle fibers.
  • In addition, DMD patients acquire osteopenia, fragility fractures, and scoliosis indicating that a deficiency in skeletal homeostasis coexists but little is known about the effects of DMD on bone and other connective tissues within the musculoskeletal system.
  • Given the common mesenchymal origin of muscle and bone, we sought to investigate bone and other musculoskeletal tissues in a DMD mouse model.
  • Here, we report that dystrophin-utrophin double knockout (dko) mice exhibit a spectrum of degenerative changes, outside skeletal muscle, in bone, articular cartilage, and intervertebral discs, in addition to reduced lifespan, muscle degeneration, spinal deformity, and cardiomyopathy previously reported.
  • We also report these mice to have a reduced capacity for bone healing and exhibit spontaneous heterotopic ossification in the hind limb muscles.
  • [MeSH-major] Bone Diseases, Metabolic / genetics. Bone Diseases, Metabolic / pathology. Dystrophin / genetics. Muscular Dystrophy, Animal / genetics. Muscular Dystrophy, Animal / pathology. Utrophin / genetics
  • [MeSH-minor] Aging, Premature / genetics. Aging, Premature / pathology. Aging, Premature / physiopathology. Animals. Calcinosis / genetics. Calcinosis / pathology. Calcinosis / physiopathology. Cardiomyopathies / genetics. Cardiomyopathies / pathology. Cardiomyopathies / physiopathology. Cartilage, Articular / pathology. Cartilage, Articular / physiopathology. Disease Models, Animal. Disease Progression. Fracture Healing / physiology. Intervertebral Disc / pathology. Intervertebral Disc / physiopathology. Mice. Mice, Inbred C57BL. Mice, Inbred mdx. Mice, Knockout. Muscle, Skeletal / pathology. Muscle, Skeletal / physiopathology. Muscular Dystrophy, Duchenne / genetics. Muscular Dystrophy, Duchenne / pathology. Muscular Dystrophy, Duchenne / physiopathology. Tibial Fractures / pathology. Tibial Fractures / physiopathology

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  • [Copyright] Copyright © 2012 Orthopaedic Research Society.
  • (PMID = 23097179.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dystrophin; 0 / Utrophin
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26. ||........ 20%  Song X, Liang F, Liu N, Luo Y, Xue H, Yuan F, Tan L, Sun Y, Xi C, Xi Y: Construction and characterization of a novel DNA vaccine that is potent antigen-specific tolerizing therapy for experimental arthritis by increasing CD4+CD25+Treg cells and inducing Th1 to Th2 shift in both cells and cytokines. Vaccine; 2009 Jan 29;27(5):690-700
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Currently available treatments for rheumatoid arthritis (RA) are often ineffective in ameliorating the progression of disease, particularly the invasive destruction of articular cartilage and bone, and RA remains incurable.

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  • (PMID = 19095031.001).
  • [ISSN] 0264-410X
  • [Journal-full-title] Vaccine
  • [ISO-abbreviation] Vaccine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Collagen Type II; 0 / Cytokines; 0 / Vaccines, DNA
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27. ||........ 20%  Yamamoto T, Schneider R, Iwamoto Y, Bullough PG: Bilateral rapidly destructive arthrosis of the hip joint resulting from subchondral fracture with superimposed secondary osteonecrosis. Skeletal Radiol; 2010 Feb;39(2):189-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Five months later, joint space narrowing had further progressed, and intra-articular injection of steroid was given in both hips.
  • There were many pseudogranulomatous lesions in the marrow space and necrotic area, where tiny fragments of bone and articular cartilage, surrounded by histiocytes and giant cells, were embedded, such as are typically seen in rapidly destructive arthrosis.


28. ||........ 20%  Liu YY, Long L, Wang SY, Guo JP, Ye H, Cui LF, Yuan GH, Li ZG: Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis. Chin Med J (Engl); 2010 Jun;123(11):1407-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane, leading to invasion of synovial tissue into the adjacent cartilage matrix with degradation of articular cartilage and bone as a consequence.
  • Dickkopf-1 (DKK-1) and osteoprotegerin (OPG) have been demonstrated to be key molecules involved in bone erosion and bone remodeling.
  • CONCLUSIONS: There was a cross-talk between DKK-1 and OPG, which involved in bone destruction in RA.


29. ||........ 20%  Miao CG, Yang YY, He X, Xu T, Huang C, Huang Y, Zhang L, Lv XW, Jin Y, Li J: New advances of microRNAs in the pathogenesis of rheumatoid arthritis, with a focus on the crosstalk between DNA methylation and the microRNA machinery. Cell Signal; 2013 May;25(5):1118-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis (RA) is a symmetrical polyarticular disease of unknown aetiology that affects primarily the articular cartilage and bone.
  • Characteristic features of RA pathogenesis are persistent inflammation, synovium hyperplasia and cartilage erosion accompanied by joint swelling and joint destruction.

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  • [Copyright] Copyright © 2013 Elsevier Inc. All rights reserved.
  • (PMID = 23385088.001).
  • [ISSN] 1873-3913
  • [Journal-full-title] Cellular signalling
  • [ISO-abbreviation] Cell. Signal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / MicroRNAs; EC 2.1.1.37 / DNA (Cytosine-5-)-Methyltransferase
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30. ||........ 20%  Bang J, Chang HW, Jung HR, Cho CH, Hur JA, Lee SI, Choi TH, Kim SH, Ha E: Melatonin attenuates clock gene cryptochrome1, which may aggravate mouse anti-type II collagen antibody-induced arthritis. Rheumatol Int; 2012 Feb;32(2):379-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial hyperplasia, and the destruction of articular cartilage and bone by MLT.

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  • (PMID = 21113809.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Collagen Type II; 0 / Cry1 protein, mouse; 0 / Cryptochromes; 0 / RNA, Messenger; EC 2.3.1.48 / CLOCK Proteins; EC 2.3.1.48 / Clock protein, mouse; JL5DK93RCL / Melatonin
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31. ||........ 19%  Brodziak-Dopierała B, Kowol J, Kwapuliński J, Kusz D, Cieliński Ł: Lead and calcium content in the human hip joint. Biol Trace Elem Res; 2011 Dec;144(1-3):6-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Concentration of lead in bone, unlike in soft tissues, increases during the lifetime and reflects severity of exposure to this element.
  • The highest mean concentration of lead was found in the cancellous bone from the femoral head, followed by articular cartilage, cortical bone and the intertrochanteric cancellous bone (0.75 μg/g).
  • The highest mean concentration of calcium was found in cancellous bone from the femoral head, followed by cancellous bone from the intertrochanteric area, cortical bone, articular cartilage and joint capsule.
  • The bone concentration of calcium decreased with age.
  • In the analysed hips, this finding was true in the cortical bone, as well as in the cancellous bone of the intertrochanteric area.
  • Statistically significant correlation between calcium and lead was found only in the hip articular cartilage.
  • [MeSH-minor] Age Factors. Aged. Cartilage, Articular / chemistry. Confidence Intervals. Data Interpretation, Statistical. Environmental Exposure. Environmental Monitoring. Female. Femur Head / chemistry. Humans. Joint Capsule / chemistry. Male. Metallurgy. Middle Aged. Osteoarthritis / surgery. Particulate Matter / analysis. Principal Component Analysis. Sex Factors. Spectrophotometry, Atomic

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  • (PMID = 21547402.001).
  • [ISSN] 1559-0720
  • [Journal-full-title] Biological trace element research
  • [ISO-abbreviation] Biol Trace Elem Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Particulate Matter; 2P299V784P / Lead; SY7Q814VUP / Calcium
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32. ||........ 19%  Pape D, Filardo G, Kon E, van Dijk CN, Madry H: Disease-specific clinical problems associated with the subchondral bone. Knee Surg Sports Traumatol Arthrosc; 2010 Apr;18(4):448-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disease-specific clinical problems associated with the subchondral bone.
  • The subchondral bone is involved in a variety of diseases affecting both the articular cartilage and bone.
  • Traumatic osteochondral defects are caused by osteochondral fractures, separating an osteochondral fragment that includes articular cartilage and both subchondral and trabecular bone from the joint surface.
  • In osteochondritis dissecans, the disease originates in the subchondral bone and secondarily affects the articular cartilage.
  • Surgical options include fragment refixation, transplantation of osteochondral autografts, or bone restoration by impacted cancellous bone grafts combined with autologous chondrocyte transplantation.
  • An insufficiency fracture of the subchondral bone may be the initiating factor of what was formerly believed to be a spontaneous osteonecrosis of the knee (SPONK).
  • Recent histopathological studies suggest that each stage of SPONK reflects different types of bone repair reactions following a fracture of the subchondral bone plate.
  • Osteoarthritis is a disease that does affect not only the articular cartilage, but also the subchondral bone.
  • This review summarizes the current status of the clinical treatment of traumatic osteochondral defects, osteochondritis dissecans, osteonecrosis, and osteoarthritis as they affect the subchondral bone region and its adjacent structures.
  • [MeSH-major] Bone and Bones. Cartilage, Articular. Osteoarthritis / surgery. Osteochondritis Dissecans / surgery. Osteonecrosis / surgery

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  • (PMID = 20151111.001).
  • [ISSN] 1433-7347
  • [Journal-full-title] Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
  • [ISO-abbreviation] Knee Surg Sports Traumatol Arthrosc
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Number-of-references] 76
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33. ||........ 19%  Wang CJ, Weng LH, Ko JY, Sun YC, Yang YJ, Wang FS: Extracorporeal shockwave therapy shows chondroprotective effects in osteoarthritic rat knee. Arch Orthop Trauma Surg; 2011 Aug;131(8):1153-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: This study investigated the effects of extracorporeal shockwave therapy (ESWT) on the subchondral bone and articular cartilage in the initiation of osteoarthritis of the knee in rats.
  • The evaluation parameters included radiograph, bone mineral density, serum levels of cartilage oligometric protein and osteocalcin, and urinary concentration of C-telopeptide of type II collagen (CTX-II), and histomorphological examination.
  • On articular cartilage, the ACLT group showed significant increases in cartilage degradation and chondrocyte apoptosis compared to the control and ACLT plus ESWT groups.
  • The ACLT plus ESWT group demonstrated significant decrease in the cartilage degradation and an increase in chondrocyte activity comparable to the control.
  • In subchondral bone, the ACLT group showed a significant decrease in bone remodeling as compared to the control and ACLT plus ESWT groups.
  • The ACLT plus ESWT group showed significant improvement in bone remodeling comparable to the control.
  • CONCLUSION: Extracorporeal shockwave therapy shows chondroprotective effect associated with improvement in subchondral bone remodeling in the initiation of ACLT OA knee model in rats.
  • [MeSH-major] Cartilage, Articular / radiation effects. High-Energy Shock Waves. Knee Joint / radiation effects. Osteoarthritis, Knee / prevention & control
  • [MeSH-minor] Animals. Anterior Cruciate Ligament / injuries. Bone Density / radiation effects. Male. Rats. Rats, Sprague-Dawley

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  • (PMID = 21387139.001).
  • [ISSN] 1434-3916
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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34. ||........ 19%  Umar S, Kumar A, Sajad M, Zargan J, Ansari M, Ahmad S, Katiyar CK, Khan HA: Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration. Rheumatol Int; 2013 Mar;33(3):657-63
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Rheumatoid arthritis is a chronic inflammatory disease characterized by the destruction of articular cartilage and bone in a chronic phase.
  • A steady increase in the articular elastase, nitric oxide and lipid peroxidation was observed in joints of arthritic rats as compared to control, whereas a significant decrease in reduced glutathione, superoxide dismutase activity and catalase was observed in collagen-induced arthritis rats as compared to control group.
  • These data confirm that erosive destruction of the joint cartilage in collagen-induced arthritis is due free radicals released by activated neutrophils and produced by other biochemical pathways.

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  • (PMID = 22527139.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Free Radicals; 31C4KY9ESH / Nitric Oxide; E750O06Y6O / Hesperidin; EC 1.11.1.6 / Catalase; EC 1.15.1.1 / Superoxide Dismutase
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35. ||........ 19%  Rautiainen J, Lehto LJ, Tiitu V, Kiekara O, Pulkkinen H, Brünott A, van Weeren R, Brommer H, Brama PA, Ellermann J, Kiviranta I, Nieminen MT, Nissi MJ: Osteochondral repair: evaluation with sweep imaging with fourier transform in an equine model. Radiology; 2013 Oct;269(1):113-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: To evaluate the status of articular cartilage and bone in an equine model of spontaneous repair by using the sweep imaging with Fourier transform (SWIFT) magnetic resonance (MR) imaging technique.
  • Six-millimeter-diameter chondral (n = 5) and osteochondral (n = 5, 3-4 mm deep into subchondral bone) defects were created in the intercarpal joints of seven 2-year-old horses and examined with SWIFT at 9.4 T after spontaneous healing for 12 months.
  • Conventional T2 maps and gradient-echo images were obtained for comparison, and histologic assessment of cartilage and micro-computed tomography (CT) of bone were performed for reference.
  • Structural bone parameters were derived from SWIFT and micro-CT datasets.
  • SWIFT produced constant signal intensity throughout cartilage, whereas T2 mapping showed elevated T2 values (P = .06) in repair tissue (mean T2 in superficial region of interest in an osteochondral lesion = 50.0 msec ± 10.2) in comparison to adjacent intact cartilage (mean T2 = 32.7 msec ± 4.2).
  • The correlation between bone volume-to-tissue volume fractions determined with SWIFT and micro-CT was significant (r = 0.83, P < .01).
  • [MeSH-major] Fracture Healing. Fractures, Bone / pathology. Fractures, Cartilage / pathology. Image Interpretation, Computer-Assisted / methods. Joints / injuries. Joints / pathology. Magnetic Resonance Imaging / methods

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  • [Copyright] © RSNA, 2013.
  • (PMID = 23674789.001).
  • [ISSN] 1527-1315
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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36. ||........ 19%  Sondergaard BC, Catala-Lehnen P, Huebner AK, Bay-Jensen AC, Schinke T, Henriksen K, Schilling S, Haberland M, Nielsen RH, Amling M, Karsdal MA: Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus. Osteoarthritis Cartilage; 2012 Feb;20(2):136-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Calcitonin is well-known for its inhibitory actions on bone-resorbing osteoclasts and recently potential beneficial effects on cartilage were shown.
  • We investigated effects of salmon calcitonin (sCT) on the articular cartilage and bone, after destabilization of the medial meniscus (DMM) in normal and sCT over-expressing mice.
  • DESIGN: Bone phenotype of transgenic (TG) C57Bl/6 mice over-expressing sCT at 6 months and 12 months was investigated by (1) serum osteocalcin and urinary deoxypyridinoline and (2) dynamic and normal histomorphometry of vertebrae bodies.
  • In subsequent evaluation of cartilage and subchondral bone changes, 44 10-week old TG or wild-type (WT) mice were randomized into four groups and subjected to DMM or sham-operations.
  • RESULTS: Trabecular bone volume (BV/TV) increased 150% after 6 months and 300% after 12 months in sCT-expressing mice when compared to WT controls (P<0.05).
  • Osteoblast number, bone formation rate and osteocalcin measurements were not affected in TG mice over-expressing sCT.
  • DMM-operated TG mice were protected against cartilage erosion and showed a 65% and 64% (P<0.001) reduction, respectively, for the two histopathological evaluation methods.
  • CONCLUSIONS: sCT over-expressing mice had higher bone volume, and were protected against cartilage erosion.
  • [MeSH-minor] Animals. Apolipoproteins E / genetics. Bone and Bones / pathology. Cartilage, Articular / pathology. Mice. Mice, Inbred C57BL. Mice, Transgenic. Osteoblasts / pathology. Osteocalcin / blood. Osteogenesis / physiology. Phenotype

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  • [Copyright] Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 22122987.001).
  • [ISSN] 1522-9653
  • [Journal-full-title] Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
  • [ISO-abbreviation] Osteoarthr. Cartil.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Apolipoproteins E; 104982-03-8 / Osteocalcin; 47931-85-1 / salmon calcitonin; 9007-12-9 / Calcitonin
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37. ||........ 19%  Roudier M, Li X, Niu QT, Pacheco E, Pretorius JK, Graham K, Yoon BR, Gong J, Warmington K, Ke HZ, Black RA, Hulme J, Babij P: Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury. Arthritis Rheum; 2013 Mar;65(3):721-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury.
  • OBJECTIVE: Sclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known.
  • The purpose of this study was to determine whether genetic loss or pharmacologic inhibition of sclerostin has an impact on knee joint articular cartilage.
  • METHODS: Expression of sclerostin was determined in articular cartilage and bone tissue obtained from mice, rats, and human subjects, including patients with knee osteoarthritis (OA).
  • RESULTS: Sclerostin expression was detected in rodent and human articular chondrocytes.
  • No difference was observed in the magnitude or distribution of sclerostin expression between normal and OA cartilage or bone.
  • Pharmacologic treatment of intact aged male rats or OVX female rats with Scl-Ab had no effect on morphologic characteristics of the articular cartilage.
  • CONCLUSION: Genetic absence of sclerostin does not alter the normal development of age-dependent OA in mice, and pharmacologic inhibition of sclerostin with Scl-Ab has no impact on articular cartilage remodeling in rats with posttraumatic OA.
  • [MeSH-major] Bone Morphogenetic Proteins / genetics. Cartilage, Articular / injuries. Cartilage, Articular / physiology. Genetic Markers / genetics. Glycoproteins / genetics. Osteoarthritis, Knee / physiopathology

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  • [Copyright] Copyright © 2013 by the American College of Rheumatology.
  • (PMID = 23233270.001).
  • [ISSN] 1529-0131
  • [Journal-full-title] Arthritis and rheumatism
  • [ISO-abbreviation] Arthritis Rheum.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Bone Morphogenetic Proteins; 0 / Genetic Markers; 0 / Glycoproteins; 0 / SOST protein, human; 0 / Sost protein, mouse; 0 / Sost protein, rat
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38. ||........ 19%  Bank RA, Groener JE, van Gemund JJ, Maaswinkel PD, Hoeben KA, Schut HA, Everts V: Deficiency in N-acetylgalactosamine-6-sulfate sulfatase results in collagen perturbations in cartilage of Morquio syndrome A patients. Mol Genet Metab; 2009 Jul;97(3):196-201
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  • [Title] Deficiency in N-acetylgalactosamine-6-sulfate sulfatase results in collagen perturbations in cartilage of Morquio syndrome A patients.
  • AIM: To investigate extracellular matrix (ECM) characteristics of cortical bone and articular cartilage of patients with Morquio syndrome A, a lysosomal storage disease caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase.
  • PATIENTS AND METHODS: Cartilage, bone, and fibroblasts from 2 unrelated patients with Morquio syndrome were used.
  • Histological analysis on bone and cartilage was carried out by means of light and electron microscopy.
  • Lysyl hydroxylation and cross-linking of collagen present in bone, cartilage, and fibroblast cultures was determined by reverse-phase high performance liquid chromatography.
  • RESULTS: No histological or biochemical differences were seen in cortical bone; furthermore, no differences were seen in the amount and modification of collagen deposited by fibroblasts.
  • Articular cartilage showed major differences: collagen fibrils show a wider range of fibril diameter, the fibrils are in mean thicker, the lysyl hydroxylation level of the triple helix is strongly decreased, the total amount of pyridinolines is in the lower ranges, and the ratio hydroxylysylpyridinoline to lysylpyridinoline is decreased.
  • CONCLUSION: The collagen of bone and the collagen deposited by fibroblasts is normal, whereas the ECM of cartilage in Morquio syndrome A patients is affected.
  • Thus, deficiency in N-acetylgalactosamine-6-sulfate sulfatase has an impact on the phenotypic properties of chondrocytes, resulting in the formation of cartilage that is more prone to degeneration, being an explanation for the occurrence of osteoarthritis in Morquio syndrome A patients at early age.
  • [MeSH-major] Cartilage, Articular / enzymology. Cartilage, Articular / pathology. Chondroitinsulfatases / deficiency. Collagen / metabolism. Mucopolysaccharidosis IV / enzymology. Mucopolysaccharidosis IV / pathology
  • [MeSH-minor] Adolescent. Adult. Bone and Bones / pathology. Bone and Bones / ultrastructure. Child, Preschool. Chondrocytes / pathology. Chondrocytes / ultrastructure. Cross-Linking Reagents / metabolism. Fatal Outcome. Female. Humans. Hydroxylation. Lysine / metabolism


39. ||........ 19%  Alvaro-Meca A, Micheloud D, Jensen J, Díaz A, García-Alvarez M, Resino S: Epidemiologic trends of cancer diagnoses among HIV-infected children in Spain from 1997 to 2008. Pediatr Infect Dis J; 2011 Sep;30(9):764-8
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  • The highest rates of cancer diagnosis in HIV-positive children were for non-Hodgkin lymphoma, malignant neoplasm of bone and articular cartilage, and Hodgkin lymphoma.


40. ||........ 19%  Pundt N, Peters MA, Wunrau C, Strietholt S, Fehrmann C, Neugebauer K, Seyfert C, van Valen F, Pap T, Meinecke I: Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis is cell cycle-dependent. Arthritis Res Ther; 2009;11(1):R16
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  • INTRODUCTION: The rheumatoid arthritis (RA) synovium is characterised by the presence of an aggressive population of activated synovial fibroblasts (RASFs) that are prominently involved in the destruction of articular cartilage and bone.

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  • (PMID = 19196465.001).
  • [ISSN] 1478-6362
  • [Journal-full-title] Arthritis research & therapy
  • [ISO-abbreviation] Arthritis Res. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / FASLG protein, human; 0 / Fas Ligand Protein; 0 / TNF-Related Apoptosis-Inducing Ligand
  • [Other-IDs] NLM/ PMC2688248
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41. ||........ 19%  Itoigawa Y, Itoi E, Sakoma Y, Yamamoto N, Sano H, Kaneko K: Attachment of the anteroinferior glenohumeral ligament-labrum complex to the glenoid: an anatomic study. Arthroscopy; 2012 Nov;28(11):1628-33
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  • The mean depth was 4.7 mm (1.6 mm on the articular cartilage and 3.0 mm on the glenoid neck) at the 2-o'clock position, 6.7 mm (2.4 mm and 4.3 mm, respectively) at the 3-o'clock position, 8.4 mm (3.0 mm and 5.4 mm, respectively) at the 4-o'clock position, and 6.8 mm (2.5 mm and 4.3 mm, respectively) at the 5-o'clock position.
  • Histologically, the AIGHL-LC attached to both the cartilage and bone in 52 shoulders (86.7%) at the 2-o'clock position and in 53 shoulders (88.3%) at the 4-o'clock position.
  • At the 4-o'clock position, the AIGHL-LC attaches to both the articular cartilage and bone in 88% of shoulders whereas it attaches only to bone in 12%.
  • Because healing of the AIGHL-LC to the articular cartilage cannot be expected, the same attachment area as to the bone and cartilage observed in normal shoulders needs to be created on the glenoid neck during Bankart repair to obtain the physiological strength of the AIGHL-LC.
  • [MeSH-major] Cartilage, Articular / anatomy & histology. Ligaments, Articular / anatomy & histology. Shoulder Joint / anatomy & histology

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  • [Copyright] Copyright © 2012 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
  • (PMID = 23107249.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. ||........ 19%  Suri S, Walsh DA: Osteochondral alterations in osteoarthritis. Bone; 2012 Aug;51(2):204-11
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  • Alterations beneath the articular cartilage at the osteochondral junction are attracting interest as possible mediators of pain and structural progression in OA.
  • Loss of osteochondral integrity removes the barrier between intra-articular and subchondral compartments, exposing subchondral bone and its nerves to abnormal chemical and biomechanical influence.
  • Loss of the clearly differentiated demarcation between bone and articular cartilage is associated with invasion of articular cartilage by blood vessels and sensory nerves, and advancing endochondral ossification.
  • Increased subchondral bone turnover is intimately associated with these alterations at the osteochondral junction.
  • Bone turnover, angiogenesis and nerve growth are also features of other diseases such as osteoporosis and cancers, for which therapeutic interventions are already advanced in their development.
  • [MeSH-major] Bone and Bones / pathology. Cartilage, Articular / pathology. Osteoarthritis / pathology

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
  • (PMID = 22023932.001).
  • [ISSN] 1873-2763
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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43. ||........ 19%  Saber T, Veale DJ, Balogh E, McCormick J, NicAnUltaigh S, Connolly M, Fearon U: Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis. PLoS One; 2011;6(8):e23540
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  • BACKGROUND: Angiogenesis is a critical early event in inflammatory arthritis, facilitating leukocyte migration into the synovium resulting in invasion and destruction of articular cartilage and bone.


44. ||........ 19%  Ahn YS, Jeong KS, Kim KS: Cancer morbidity of professional emergency responders in Korea. Am J Ind Med; 2012 Sep;55(9):768-78
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  • In non-firefighter ERs, colorectal (SIR = 2.51, 95% CI = 1.20-4.61) and bone and articular cartilage cancers (SIR = 9.53, 95% CI = 1.07-34.41) were significantly higher than those of Korean men.

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  • [Copyright] Copyright © 2012 Wiley Periodicals, Inc.
  • (PMID = 22628010.001).
  • [ISSN] 1097-0274
  • [Journal-full-title] American journal of industrial medicine
  • [ISO-abbreviation] Am. J. Ind. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinogens, Environmental
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45. ||........ 19%  Abdeen A, Hoang BH, Athanasian EA, Morris CD, Boland PJ, Healey JH: Allograft-prosthesis composite reconstruction of the proximal part of the humerus: functional outcome and survivorship. J Bone Joint Surg Am; 2009 Oct;91(10):2406-15
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  • Reconstructive options are limited because of the loss of periarticular soft-tissue stabilizers of the glenohumeral joint in addition to the loss of bone and articular cartilage.
  • Functional outcome and implant survival were analyzed on the basis of the amount of deltoid resection, whether the glenohumeral resection had been extra-articular or intra-articular, and the length of the humerus that had been resected.
  • Extra-articular resections were associated with lower Musculoskeletal Tumor Society scores.
  • Four patients required an additional bone-grafting procedure to treat a delayed union of the osteosynthesis site.
  • Deltoid preservation and intra-articular resection are associated with a greater range of shoulder motion and a superior functional outcome, respectively.
  • [MeSH-major] Arthroplasty, Replacement. Bone Neoplasms / surgery. Joint Prosthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Transplantation. Child. Female. Humans. Limb Salvage. Male. Middle Aged. Reconstructive Surgical Procedures. Recovery of Function. Retrospective Studies. Shoulder. Transplantation, Homologous. Young Adult

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  • (PMID = 19797576.001).
  • [ISSN] 1535-1386
  • [Journal-full-title] The Journal of bone and joint surgery. American volume
  • [ISO-abbreviation] J Bone Joint Surg Am
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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46. ||........ 19%  Li Q, Zhang L, Li Z, Mu S, Cheng T, Tian F, Liu Y: [Effect of xianlinggubao in suppressing articular cartilage degeneration of anterior cruciate ligament transection model in rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2009 Mar;23(3):294-8
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  • [Title] [Effect of xianlinggubao in suppressing articular cartilage degeneration of anterior cruciate ligament transection model in rats].
  • OBJECTIVE: To investigate the effects of xianlinggubao (XLGB) on subchondral bone and articular cartilage in the rat osteoarthritis model induced by anterior cruciate ligament transection (ACLT).
  • After 12 weeks, the gross appearance of femoral condyles was observed, the degree of cartilage degeneration was scored by Mankin scoring system.
  • The immunostaining for MMP-13 was performed to investigate the effect of XLGB on prevention of cartilage matrix loss.
  • The bone mineral density (BMD) measurement and bone histomorphometric analysis were done in subchondral bone of right distal femur and proximal tibia after 12 weeks.
  • BMD of the subchondral bone in the group B was significantly lower than those in the groups A and C (P < 0.05).
  • The bone mass in group C were significantly higher than that in group B (P < 0.05).
  • CONCLUSION: Oral administration of XLGB (250 mg/kg per day) for 12 weeks could prevent the cartilage degeneration of rats after ACLT, down-regulating MMP-13 and increasing subchondral bone mass might participate in this process.
  • [MeSH-major] Cartilage, Articular / pathology. Osteoarthritis, Knee / drug therapy. Osteoarthritis, Knee / pathology. Phytotherapy
  • [MeSH-minor] Animals. Anterior Cruciate Ligament / injuries. Bone Density. Disease Models, Animal. Female. Knee Joint / surgery. Matrix Metalloproteinase 13 / metabolism. Random Allocation. Rats. Rats, Sprague-Dawley

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  • (PMID = 19366137.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.4.24.- / Matrix Metalloproteinase 13; EC 3.4.24.- / Mmp13 protein, rat
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47. ||........ 19%  Pan J, Wang B, Li W, Zhou X, Scherr T, Yang Y, Price C, Wang L: Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints. Bone; 2012 Aug;51(2):212-7
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  • [Title] Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints.
  • Subchondral bone is hypothesized to be involved in OA development.
  • We previously detected measurable transport of solute across the mineralized calcified cartilage in normal joints, suggesting a potential cross-talk between subchondral bone and cartilage.
  • Tracer diffusivity was found to be 0.30±0.17 and 0.33±0.20μm(2)/s within the calcified cartilage and 0.12±0.04 and 0.07±0.03μm(2)/s across the osteochondral interface in the aged (20-24-month-old, n=4) and DMM OA joints (5-month-old, n=5), respectively, which were comparable to the control values for the contralateral non-operated joints in the DMM mice (0.48±0.13 and 0.12±0.06μm(2)/s).
  • Although we did not detect significant changes in tissue matrix permeability in OA joints, we found i) an increased number of vessels invading the calcified cartilage (and sometimes approaching the tidemark) in the aged (+100%) and DMM (+50%) joints relative to the normal age controls; and ii) a 60% thinning of the subchondral bone and calcified cartilage layers in the aged joints (with no significant changes detected in the DMM joints).
  • These results suggested that the capacity for cross-talk between subchondral bone and articular cartilage could be elevated in OA.
  • Further studies are needed to identify the direction of the cross-talk, the signaling molecules involved, and to test whether subchondral bone initiates OA development and could serve as a pharmaceutical target for OA treatment.
  • [MeSH-major] Bone and Bones / pathology. Cartilage, Articular / pathology. Joints / pathology. Osteoarthritis / pathology

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  • [Copyright] Copyright © 2011 Elsevier Inc. All rights reserved.
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  • (PMID = 22197997.001).
  • [ISSN] 1873-2763
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / P20 RR016458-10; United States / NCRR NIH HHS / RR / P20RR016458; United States / NIAMS NIH HHS / AR / R01 AR054385-05; United States / NIAMS NIH HHS / AR / R01AR054385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 2321-07-5 / Fluorescein
  • [Other-IDs] NLM/ NIHMS345623; NLM/ PMC3335971
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48. ||........ 19%  Grutter PW, McFarland EG, Zikria BA, Dai Z, Petersen SA: Techniques for suture anchor removal in shoulder surgery. Am J Sports Med; 2010 Aug;38(8):1706-10
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  • Although suture anchor complications after arthroscopic shoulder surgery are uncommon, they can be devastating, such as articular cartilage or bone loss secondary to a dislodged or prominent suture anchor.

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  • (PMID = 20566718.001).
  • [ISSN] 1552-3365
  • [Journal-full-title] The American journal of sports medicine
  • [ISO-abbreviation] Am J Sports Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. ||........ 19%  Yamamoto K, Igawa K, Ueno H, Yano F, Chung UI, Koshima I: Temporal and spatial changes in element distribution in bone and cartilage. J Orthop Sci; 2009 Mar;14(2):198-203
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Temporal and spatial changes in element distribution in bone and cartilage.
  • BACKGROUND: Bone and cartilage act as reservoirs for a number of elements, and the perturbation of these elements is suggested to contribute to various diseases.
  • We performed element mapping in the bone and cartilage of normal mouse knee joints.
  • We measured element distribution in articular cartilage, trabecular bone, cortical bone, joint cartilage, growth plates, and joint cavities using energy dispersive X-ray spectrometry.
  • (1) The main elements in articular cartilage of 1-day-old mice were Na, O, P, S, and Ca; and those in bone were Na, O, P, S, K, Ca, and Mg. (2) The main elements in the growth plate of 3-week-old mice were Na, N, O, P, S, Cl, K, and Ca; those in joint cartilage were Na, O, P, S, Cl, and K; and those in bone were Na, O, P, Ca, and Mg. (3) The main elements in the growth plate of 20-week-old mice were Na, O, P, S, Cl, K, and Ca; and those in bone were Na, O, P, S, K, Ca, and Mg.
  • On the first day after birth, a spatial change was seen in the growth plate cartilage: the more the cartilage matured toward hypertrophy, the more S and Ca it contained.
  • Temporal changes in element distribution in the growth plate cartilage, articular cartilage, and bone were observed.
  • Growth plate cartilage of the older mice contained more S and Ca than that of the younger mice.
  • Bone of the older mice contained more Ca and Mg than that of the younger mice.
  • Spatial changes in element distribution in the cortical bone were also seen; that is, the more the cortical bone matured toward diaphysis, the more Mg and the less S it contained.
  • No significant temporal or spatial changes in the distribution of P, Cl, or K were seen.
  • In particular, it may help distinguish between immature cartilage and mature cartilage based on the Ca and S contents.
  • [MeSH-major] Calcification, Physiologic / physiology. Cartilage, Articular / chemistry. Growth Plate / chemistry. Minerals / analysis

  • MedlinePlus Health Information. consumer health - Minerals.
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  • (PMID = 19337812.001).
  • [ISSN] 1436-2023
  • [Journal-full-title] Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
  • [ISO-abbreviation] J Orthop Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Minerals
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50. ||........ 19%  Henson F, Getgood A: The use of scaffolds in musculoskeletal tissue engineering. Open Orthop J; 2011;5 Suppl 2:261-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A significant amount of basic science and clinical research has been focused on the regeneration of musculoskeletal tissues including bone, articular cartilage, meniscus, ligament and tendon.

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  • (PMID = 21886690.001).
  • [ISSN] 1874-3250
  • [Journal-full-title] The open orthopaedics journal
  • [ISO-abbreviation] Open Orthop J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC3149868
  • [Keywords] NOTNLM ; Musculoskeletal tissue engineering / scaffolds.
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2. Definitions


3. Related RMF webpages
1. neoplasm of uncertain behavior of bone and articular cartilage disorder
2. neoplasm of uncertain behavior nos disorder
3. neoplasm of uncertain behavior of trachea bronchus and lung
4. chondrolysis of articular cartilage disorder
5. articular cartilage disorder nos
6. cartilage articular disorder or disease
7. cartilage articular
8. tear articular cartilage
9. articular cartilage degeneration
10. tear knee cartilage articular
11. articular cartilage degeneration knee
12. m neoplasm uncertain whether benign or malignant
13. secondary malignant neoplasm of bone disorder
14. deformity nose bone nose cartilage
15. congenital anomaly of cartilage disorder
16. mgus monoclonal gammopathy of uncertain significance
17. rapid eye movement sleep behavior disorder disorder
18. behavior related disorder
19. behavior disorder disruptive
20. rem sleep behavior disorder
21. neoplasm of uterus disorder
22. neoplasm of vulva disorder
23. neoplasm of ovary disorder
24. benign neoplasm of liver disorder
25. benign neoplasm of larynx disorder
26. neoplasm of sweat gland disorder
27. malignant neoplasm of abdomen disorder
28. benign neoplasm of muscle disorder
29. benign neoplasm of ovary disorder
30. benign neoplasm of kidney disorder
31. mast cell neoplasm disorder
32. benign neoplasm of heart disorder
33. benign neoplasm of pancreas disorder
34. benign neoplasm nos disorder
35. neoplasm history neoplasm in situ
36. malignant neoplasm of testis nos disorder
37. benign neoplasm of uterus nos disorder
38. benign neoplasm of soft tissue disorder
39. secondary malignant neoplasm of ovary disorder
40. malignant neoplasm of gastrointestinal tract disorder
41. secondary malignant neoplasm of lung disorder
42. benign neoplasm of thyroid gland disorder
43. benign neoplasm of adrenal gland disorder
44. malignant neoplasm of vagina nos disorder
45. malignant neoplasm of spleen nos disorder
46. secondary malignant neoplasm of kidney disorder
47. secondary malignant neoplasm of pleura disorder
48. malignant neoplasm of skin nos disorder
49. malignant neoplasm of soft tissue disorder
50. benign neoplasm of parotid gland disorder

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