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1. Biomedical articles (top 50; 2010 to 2015)
1. Donoso S A, Urzúa R, Slachevsky C H A, Silva R C: [Paretic neurosyphilis: report of five patients]. Rev Med Chil; 2012 May;140(5):625-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In all, the cerebrospinal fluid had a mononuclear pleocytosis and a positive VDRL.

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  • (PMID = 23096668.001).
  • [ISSN] 0717-6163
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
  • [Chemical-registry-number] 0 / Penicillins
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2. Casal CA, Silva MO, Costa IB, Araújo Eda C, Corvelo TC: Molecular detection of Treponema pallidum sp. pallidum in blood samples of VDRL-seroreactive women with lethal pregnancy outcomes: a retrospective observational study in northern Brazil. Rev Soc Bras Med Trop; 2011 Jul-Aug;44(4):451-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular detection of Treponema pallidum sp. pallidum in blood samples of VDRL-seroreactive women with lethal pregnancy outcomes: a retrospective observational study in northern Brazil.
  • INTRODUCTION: Although control measures of maternal and congenital syphilis are available in Brazil, difficulties exist within the healthcare network in providing a laboratory diagnosis of the infection during the prenatal period.
  • The objective of this study was to confirm the presence of Treponema pallidum by PCR in women with positive VDRL serology and lethal pregnancy outcomes, i.e., abortion, stillbirth and neonatal death.
  • Serum samples and DNA from whole blood were obtained at the time of screening by the VDRL test.
  • RESULTS: During the study period, 0.7% (36/4,912) of women with lethal pregnancy outcomes presented a positive VDRL test.
  • Among women who were submitted to the VDRL test during the prenatal period, only four of the nine seroreactive patients underwent treatment.


3. Badie, Yavari Z, Esmaeeli S, Paydary K, Emamzadeh-Fard S, Seyedalinaghi S, Rasoulinejad M: Prevalence survey of infection with Treponema pallidum among HIV-positive patients in Tehran. Asian Pac J Trop Biomed; 2013 Apr;3(4):334-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence survey of infection with Treponema pallidum among HIV-positive patients in Tehran.
  • OBJECTIVE: To identify the frequency of syphilis among Iranian HIV-positive patients.
  • The lab tests including CD4 cell count, cerebrospinal fluid, veneral disease research laboratory (VDRL), fluorescent treponema antibody-absorption (FTA-Abs) and viral load were performed for all the patients.
  • RESULTS: Of all 450 HIV-positive patients, 24 (5.3%) had a positive VDRL test and only two men had a FTA-Abs positive test which means 0.45% of them had a definite co-infection of syphilis.
  • 65.3% of the HIV-positive patients were injection drug users that the co-infection prevalence of them was 0.7%.

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  • [Cites] J Microbiol Immunol Infect. 2012 Oct;45(5):337-42 [22698630.001]
  • [Cites] Cochrane Database Syst Rev. 2012;8:CD007933 [22895969.001]
  • [Cites] Sex Transm Infect. 2011 Feb;87(1):9-16 [20924048.001]
  • [Cites] Arch Iran Med. 2010 Jul;13(4):318-23 [20597566.001]
  • [Cites] J Acquir Immune Defic Syndr. 2010 Jan;53(1):86-94 [20035164.001]
  • [Cites] MMWR Morb Mortal Wkly Rep. 2007 Jun 29;56(25):625-8 [17597693.001]
  • [Cites] Clin Infect Dis. 2007 May 1;44(9):1222-8 [17407043.001]
  • [Cites] Qual Life Res. 2006 Aug;15(6):941-9 [16900275.001]
  • [Cites] Rev Soc Bras Med Trop. 2000 Jan-Feb;33(1):47-52 [10881118.001]
  • [Cites] Sex Transm Dis. 2000 May;27(5):259-65 [10821597.001]
  • (PMID = 23620862.001).
  • [ISSN] 2221-1691
  • [Journal-full-title] Asian Pacific journal of tropical biomedicine
  • [ISO-abbreviation] Asian Pac J Trop Biomed
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC3634935
  • [Keywords] NOTNLM ; Co-infection / HIV/AIDS / Syphilis
  • [General-notes] NLM/ Original DateCompleted: 20130508
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4. Campos AL, Araújo MA, Melo SP, Gonçalves ML: [Epidemiology of gestational syphilis in Fortaleza, Ceará State, Brazil: an uncontrolled disease]. Cad Saude Publica; 2010 Sep;26(9):1747-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Epidemiology of gestational syphilis in Fortaleza, Ceará State, Brazil: an uncontrolled disease].
  • This cross-sectional study investigated the epidemiological profile of pregnant women with positive VDRL in Fortaleza, Ceará State, Brazil, in 2008.

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  • (PMID = 20877935.001).
  • [ISSN] 1678-4464
  • [Journal-full-title] Cadernos de saúde pública
  • [ISO-abbreviation] Cad Saude Publica
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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5. Maloney K: Idiopathic intracranial hypertension as an initial presentation of systemic lupus erythematosus. BMJ Case Rep; 2013;2013
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • She had no prior history of headaches, use of hormonal contraception or other medications, recent weight changes or family history of autoimmune disease.
  • Laboratory investigations revealed a normochromic normocytic anaemia, leucopenia and lymphopenia.
  • Further investigations revealed a positive direct coombs test, positive antinuclear antibodies (ANA) positive antidouble-stranded DNA (dsDNA) and false positive VDRL.


6. Saje A, Tomažič J: Syphilis and HIV co-infection: excellent response to multiple doses of benzathine penicillin. Acta Dermatovenerol Alp Pannonica Adriat; 2014 Mar;23(1):1-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The primary endpoint was response to therapy (fourfold reduction of VDRL at month 12).
  • METHODS: Three hundred forty-two paper records were reviewed and MSM with positive VDRL and/or TPHA and serological follow up of at least 12 months were enrolled in the survey.


7. Cooper IF, Siadaty MS: 'Laboratory Procedures' associated with 'Positive Vdrl': Top Publications. BioMedLib Review; LaboratoryProcedure;PositiveVdrl:705079630. ISSN: 2331-5717. 2014/4/28
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  • [Title] 'Laboratory Procedures' associated with 'Positive Vdrl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory Procedure' for 'positive vdrl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory Procedure'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 612 publications.
  • Here are the top 10.
  • Jindal N et al: Prevalence of syphilis and biological false positive reactions in VDRL test among injecting drug users: a preliminary study.
  • Mathai E et al: Audit of management of pregnant women with positive VDRL tests.
  • Feder HM Jr et al: The asymptomatic patient with a positive VDRL test.
  • Schueller WA et al: Immunizations and false positive VDRL tests in military recruits.
  • Maddison PJ et al: False positive VDRL and anti-Ro antibodies related to pregnancy outcome.
  • Busby G et al: Value of routine long bone radiographs in management of babies with a positive VDRL at the Mount Hope Women's Hospital.
  • Al Attia HM: False positive VDRL (BFP-STS) and systemic lupus erythematosus; new data in clinico-laboratory associations.
  • Haghighi L et al: Biological false positive VDRL test in malaria.
  • Musher DM: Evaluation and management of an asymptomatic patient with a positive VDRL reaction.
  • Peled N et al: [Antenatal follow-up and the attitude to a newborn of a mother with a positive VDRL test].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705079630.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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8. Panke CL, Bonilha MM, Loreto MS, Savaris RF: Incidence of uterine post abortion infection at Hospital de Clínicas de Porto Alegre. Is prophylactic antibiotic necessary? Rev Col Bras Cir; 2014 Mar-Apr;41(2):100-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We calculated emographic and laboratory data of the study population, number needed for treatment (NNT) and number needed to harm (NNH).
  • The majority of the population was white (79%); HIV prevalence and positive VDRL was 0.3% and 2%, respectively.

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  • (PMID = 24918722.001).
  • [ISSN] 1809-4546
  • [Journal-full-title] Revista do Colégio Brasileiro de Cirurgiões
  • [ISO-abbreviation] Rev Col Bras Cir
  • [Language] eng; por
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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9. Giugno CS, Silva AL, Fuhrich DG, Rabaioli PS, Gonçalves KG, Sartor NC, Savaris RF: Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: a retrospective cohort study. Int J STD AIDS; 2013 Nov;24(11):893-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To compare the rates of cure of septic abortion and pelvic inflammatory disease using a daily dose of clindamycin with gentamicin versus divided doses, we conducted a retrospective cohort study, where the electronic records of 661 patients who used clindamycin 1 × , 3 × or 4 ×/day (groups 1, 3 and 4, respectively) between September 2002 and August 2010 were analysed.
  • Secondary endpoints were percentage of adverse effects related to medication regimen and the prevalence of positive VDRL and HIV.
  • Similar conditions were observed in all groups - septic abortion: 167/116/123; pelvic inflammatory disease: 73/95/87 (groups 1, 3 and 4, respectively).
  • [MeSH-major] Abortion, Septic / drug therapy. Anti-Bacterial Agents / administration & dosage. Clindamycin / administration & dosage. Gentamicins / administration & dosage. Pelvic Inflammatory Disease / drug therapy

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  • (PMID = 23970615.001).
  • [ISSN] 1758-1052
  • [Journal-full-title] International journal of STD & AIDS
  • [ISO-abbreviation] Int J STD AIDS
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Gentamicins; 3U02EL437C / Clindamycin
  • [Keywords] NOTNLM ; PID / Septic abortion / antibiotics / clindamycin / dose / gentamicin / pelvic inflammatory disease / sexually transmitted infection / treatment
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10. Adolf R, Bercht F, Aronis ML, Lunardi LW, Schechter M, Sprinz E: Prevalence and risk factors associated with syphilis in a cohort of HIV positive individuals in Brazil. AIDS Care; 2012;24(2):252-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence and risk factors associated with syphilis in a cohort of HIV positive individuals in Brazil.
  • Inclusion criteria were having CD4 + T cell count and viral load at baseline, and syphilis serology tests (venereal disease research laboratory [VDRL] > 1:64 or a positive VDRL plus a positive treponemal test).


11. Cooper IF, Siadaty MS: 'Laboratory or Test Results' associated with 'Positive Vdrl': Top Publications. BioMedLib Review; LaboratoryOrTest;PositiveVdrl:706186989. ISSN: 2331-5717. 2014/5/24
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  • [Title] 'Laboratory or Test Results' associated with 'Positive Vdrl': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory or Test Result' for 'positive vdrl'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory or Test Result'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 18 publications, and group two 515 publications.
  • Here are the top 10.
  • Jindal N et al: Prevalence of syphilis and biological false positive reactions in VDRL test among injecting drug users: a preliminary study.
  • Mathai E et al: Audit of management of pregnant women with positive VDRL tests.
  • Feder HM Jr et al: The asymptomatic patient with a positive VDRL test.
  • Mola GD et al: A case-control study of VDRL-positive antenatal clinic attenders at the Port Moresby General Hospital Antenatal Clinic and Labour Ward to determine outcomes, sociodemographic features and associated risk factors.
  • Busby G et al: Value of routine long bone radiographs in management of babies with a positive VDRL at the Mount Hope Women's Hospital.
  • Al Attia HM: False positive VDRL (BFP-STS) and systemic lupus erythematosus; new data in clinico-laboratory associations.
  • OLANSKY S et al: Negative Kahn standard and positive VDRL slide tests for syphilis; clinicoserologic evaluation of preselected patients.
  • Schueller WA et al: Immunizations and false positive VDRL tests in military recruits.
  • Haghighi L et al: Biological false positive VDRL test in malaria.
  • Maddison PJ et al: False positive VDRL and anti-Ro antibodies related to pregnancy outcome.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706186989.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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12. Cooper IF, Siadaty MS: 'Laboratory or Test Results' associated with 'Vdrl Test': Top Publications. BioMedLib Review; LaboratoryOrTest;VdrlTest:706103059. ISSN: 2331-5717. 2014/1/22
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  • [Title] 'Laboratory or Test Results' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory or Test Result' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory or Test Result'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 833 publications.
  • Here are the top 10.
  • Sharma M et al: Syphilis serology in human immunodeficiency virus patients: a need to redefine the VDRL test cut-off for biological false-positives.
  • Jindal N et al: Prevalence of syphilis and biological false positive reactions in VDRL test among injecting drug users: a preliminary study.
  • Dorwart BB et al: Comparison of rapid plasma reagin card test and venereal disease research laboratory test in the detection of biological false positive reactions in systemic lupus erythematosus.
  • Mathai E et al: Audit of management of pregnant women with positive VDRL tests.
  • Feder HM Jr et al: The asymptomatic patient with a positive VDRL test.
  • Wuepper KD et al: False-positive reaction to VDRL test with prozone phenomena. Association with lymphosarcoma.
  • : Is there an association between narcotic addiction and false-positive VDRL test results?.
  • Schueller WA et al: Immunizations and false positive VDRL tests in military recruits.
  • Jouquan J et al: Accelerated hypertension associated with lupus anticoagulant and false-positive VDRL in systemic lupus erythematosus.
  • Al Attia HM: False positive VDRL (BFP-STS) and systemic lupus erythematosus; new data in clinico-laboratory associations.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706103059.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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13. Cooper IF, Siadaty MS: 'Findings' associated with 'Vdrl Test': Top Publications. BioMedLib Review; Finding;VdrlTest:706265202. ISSN: 2331-5717. 2014/10/24
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  • [Title] 'Findings' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Finding' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Finding'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 22 publications, and group two 1134 publications.
  • Here are the top 10.
  • Casal CA et al: Molecular detection of Treponema pallidum sp. pallidum in blood samples of VDRL-seroreactive women with lethal pregnancy outcomes: a retrospective observational study in northern Brazil.
  • Pope V et al: Replacement for 30-milliliter flat-bottomed, glass-stoppered, round bottles used in VDRL antigen preparation.
  • Castro AR et al: Use of synthetic cardiolipin and lecithin in the antigen used by the venereal disease research laboratory test for serodiagnosis of syphilis.
  • Gupta N et al: Screening by VDRL test to detect hidden cases of syphilis.
  • Sequeira PJ: Serological diagnosis of untreated early syphilis. Importance of the differences in THA, TPHA, and VDRL test titres.
  • Drabick JJ et al: Utility of the VDRL test in HIV-seropositive patients.
  • Feraru ER et al: Neurosyphilis in AIDS patients: initial CSF VDRL may be negative.
  • Kośmiderski S et al: [Polystyrene latex used for VDRL tests].
  • Schueller WA et al: Immunizations and false positive VDRL tests in military recruits.
  • Maddison PJ et al: False positive VDRL and anti-Ro antibodies related to pregnancy outcome.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706265202.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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14. Cooper IF, Siadaty MS: 'Laboratory or Test Results' associated with 'Laboratory Data': Top Publications. BioMedLib Review; LaboratoryOrTest;LaboratoryData:706073090. ISSN: 2331-5717. 2014/9/22
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  • [Title] 'Laboratory or Test Results' associated with 'Laboratory Data': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory or Test Result' for 'laboratory data'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory or Test Result'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 13 publications, and group two 124661 publications.
  • Here are the top 7.
  • Liu J et al: Prototype integration of protein electrophoresis laboratory results in an information warehouse to improve workflow and data analysis.
  • Ben-Aryeh H et al: Salivary flow-rate and composition in schizophrenic patients on clozapine: subjective reports and laboratory data.
  • Schoenberg BS: The "abnormal" laboratory result. Problems in interpreting laboratory data.
  • McLure M et al: EDI (electronic data interchange) provides strategy for laboratory results reporting.
  • Were MC et al: Enhanced laboratory reports: using health information exchange data to provide contextual information to laboratory results for practices without electronic records.
  • Al Attia HM: False positive VDRL (BFP-STS) and systemic lupus erythematosus; new data in clinico-laboratory associations.
  • Diudina IO et al: [Comparative data charasteristic of laboratory examination of patients with chronic heart failure of ishemic origin with systolic left ventricular dysfunction and preserved left ventricular ejection fraction].

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706073090.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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15. Cooper IF, Siadaty MS: 'Qualitative Concepts' associated with 'Vdrl Test': Top Publications. BioMedLib Review; QualitativeConcept;VdrlTest:706290411. ISSN: 2331-5717. 2014/1/25
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  • [Title] 'Qualitative Concepts' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Qualitative Concept' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Qualitative Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 468 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Amino Acids, Peptides, or Proteins' associated with 'Vdrl Test': Top Publications.
  • Gupta N et al: Screening by VDRL test to detect hidden cases of syphilis.
  • Wöhrl S et al: Neurosyphilis is unlikely in patients with late latent syphilis and a negative blood VDRL-test.
  • Park Y et al: Evaluation of a fully automated treponemal test and comparison with conventional VDRL and FTA-ABS tests.
  • Pastuszczak M et al: Cerebrospinal Fluid Abnormalities in HIV-Negative Patients with Secondary and Early Latent Syphilis and Serum VDRL ≥ 1:32.
  • Wiwanitkit V: Biological false reactive VDRL tests: when to re-test?.
  • Choi SJ et al: Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests.
  • Ikeme AC et al: The relevance of VDRL as routine test in pregnant women: a critcal study.
  • Al Attia HM: False positive VDRL (BFP-STS) and systemic lupus erythematosus; new data in clinico-laboratory associations.
  • Wiwanitkit V: Effect of gold nanoparticle solution on VDRL reactive CSF.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706290411.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. Cooper IF, Siadaty MS: 'Laboratory Procedures' associated with 'Vdrl Test': Top Publications. BioMedLib Review; LaboratoryProcedure;VdrlTest:707234277. ISSN: 2331-5717. 2014/3/7
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  • [Title] 'Laboratory Procedures' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory Procedure' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory Procedure'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 49 publications, and group two 524 publications.
  • Here are the top 10.
  • Oliveira VM et al: [Syphilis detection using ELISA and VDRL tests on blood donors at the blood center of Guarapuava, State of Paraná].
  • Cooper IF et al: 'Steroids' associated with 'Vdrl Test': Top Publications.
  • Wiwanitkit V: Biological false reactive VDRL tests: when to re-test?.
  • Choi SJ et al: Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests.
  • Mathai E et al: Audit of management of pregnant women with positive VDRL tests.
  • Castro R et al: Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests.
  • Harxhi A et al: Multiple ulcers in primary syphilis with negative rapid plasma reagin and Venereal Disease Research Laboratory tests: an unusual presentation during the re-emergence of syphilis in Albania.
  • Castro AR et al: Use of synthetic cardiolipin and lecithin in the antigen used by the venereal disease research laboratory test for serodiagnosis of syphilis.
  • Meyer MP et al: Whole-blood hemagglutination inhibition test for venereal disease research laboratory (VDRL) antibodies.
  • Park Y et al: Evaluation of a fully automated treponemal test and comparison with conventional VDRL and FTA-ABS tests.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707234277.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. Spinner CD, Noe S, Schwerdtfeger C, Todorova A, Gaa J, Schmid RM, Busch DH, Neuenhahn M: Acute hypophysitis and hypopituitarism in early syphilitic meningitis in a HIV-infected patient: a case report. BMC Infect Dis; 2013;13:481
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE PRESENTATION: A 46 year old HIV-positive male patient came in to our emergency department in the late evening with acute fever, rapidly progressive cephalgia and photophobia.
  • A reactive Treponema pallidum particle agglutination (TPPA) assay with positive Treponema pallidum-specific IgG/IgM immunofluorescence as well as a highly reactive Veneral diseases research laboratory (VDRL) test confirmed the diagnosis.
  • Liquor pleocytosis, liquor protein elevation and a highly positive VDRL test in cerebrospinal fluid (CSF) were interpreted in context of the clinical symptoms as neurosyphilitic manifestations within an early syphilis infection (stage II).
  • Advanced endocrine laboratory testing revealed hypopituitarism.
  • CONCLUSION: We report to the best of our knowledge the first case of a HIV-positive patient with acute hypophysitis and hypopituarism due to early neurosyphilis infection.

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  • (PMID = 24134407.001).
  • [ISSN] 1471-2334
  • [Journal-full-title] BMC infectious diseases
  • [ISO-abbreviation] BMC Infect. Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Syphilitic aseptic meningitis
  • [Other-IDs] NLM/ PMC3853997
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18. Fraga D, Muller AL, Czykiel MS, De Armas Y, Wissmann G, Goldani LZ: Detection of Treponema pallidum by semi-nested PCR in the cerebrospinal fluid of asymptomatic HIV-infected patients with latent syphilis. Clin Lab; 2014;60(12):2051-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In addition, none of these 5 CSF samples presented a positive VDRL reaction.
  • Serum VDRL titers were similar between patients with positive and negative CSF T. pallidum DNA.
  • Most patients with detectable T. pallidum DNA presented low serum VDRL titers.
  • A higher serum VDRL titer of 1:64 was observed in only one patient.

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  • (PMID = 25651740.001).
  • [ISSN] 1433-6510
  • [Journal-full-title] Clinical laboratory
  • [ISO-abbreviation] Clin. Lab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Bacterial
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19. Jäger S, Meier FM: [Syphilis-associated uveitis in Switzerland]. Klin Monbl Augenheilkd; 2011 Apr;228(4):330-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • All patients tested positive for syphilis-specific serologic testing (VDRL, TPPA, FTA-ABS test).
  • 5 patients showed a weakly positive VDRL and FTA-ABS test in the cerebrospinal fluid, one patient tested clearly positive.
  • In addition 5 patients tested positive for HIV.
  • Ophthalmologists can play an important role in the diagnosis and management of this severe disease.

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 21484640.001).
  • [ISSN] 1439-3999
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] Q42T66VG0C / Penicillin G
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20. Lin CF, Twu SJ, Chen PH, Cheng JS, Wang JD: Prevalence and determinants of hepatitis B antigenemia in 15,007 inmates in Taiwan. J Epidemiol; 2010;20(3):231-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Blood samples were collected and screened for hepatitis B surface antigen and Venereal Disease Research Laboratory (VDRL) reactivity.
  • The prevalence of a positive VDRL test result was 1.01%.
  • [MeSH-minor] Adolescent. Adult. Blood Transfusion / adverse effects. Child. Disease Transmission, Infectious / statistics & numerical data. Female. Humans. Male. Middle Aged. Odds Ratio. Prevalence. Questionnaires. Risk Factors. Seroepidemiologic Studies. Serologic Tests. Substance Abuse, Intravenous / complications. Taiwan / epidemiology. Tattooing / adverse effects. Young Adult

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  • (PMID = 20431237.001).
  • [ISSN] 1349-9092
  • [Journal-full-title] Journal of epidemiology / Japan Epidemiological Association
  • [ISO-abbreviation] J Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Hepatitis B Surface Antigens
  • [Other-IDs] NLM/ PMC3900846
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21. Cooper IF, Siadaty MS: 'Laboratory Procedures' associated with 'Accelerated Hypertension': Top Publications. BioMedLib Review; LaboratoryProcedure;AcceleratedHypertension:705014840. ISSN: 2331-5717. 2014/4/27
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  • [Title] 'Laboratory Procedures' associated with 'Accelerated Hypertension': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Laboratory Procedure' for 'accelerated hypertension'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Laboratory Procedure'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 5649 publications.
  • Here are the top 10.
  • Tanaka S et al: Plasma prolactin levels in patients with essential hypertension, malignant hypertension and secondary hypertension.
  • Kantachuvesiri S et al: Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats.
  • Ideishi M et al: An accelerated hypertension with neither malignant nephrosclerosis nor elevation of plasma renin activity.
  • Jouquan J et al: Accelerated hypertension associated with lupus anticoagulant and false-positive VDRL in systemic lupus erythematosus.
  • Fujishima M et al: Cerebrospinal fluid lactate and pyruvate concentrations in patients with malignant hypertension.
  • Jones DB: The renal vascular lesions of severe and malignant hypertension: a light-immunofluorescent microscopy, transmission and scanning electron-microscopy study.
  • Ogata J et al: Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension. I. A light- and electron-microscopic study of the brain.
  • Dardik BN et al: Malignant hypertension, fibrinoid deposition, and fibrinogen electrophoresis.
  • Bonnet F et al: [Application of the saralasin test to the treatment of malignant or accelerated arterial hypertension (author's transl)].
  • Pitcock JA et al: Malignant hypertension in blacks. Malignant intrarenal arterial disease as observed by light and electron microscopy.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705014840.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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22. Cooper IF, Siadaty MS: 'Population Groups' associated with 'Audit Management': Top Publications. BioMedLib Review; PopulationGroup;AuditManagement:707407584. ISSN: 2331-5717. 2014/2/10
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  • [Title] 'Population Groups' associated with 'Audit Management': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Population Group' for 'audit management'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Population Group'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 38 publications, and group two 8923 publications.
  • Here are the top 10.
  • Potter J et al: National audit of continence care for older people: management of faecal incontinence.
  • Wagg A et al: National audit of continence care for older people: management of urinary incontinence.
  • Kerr J et al: An audit of clinical practice in the management of head injured patients following the introduction of the Scottish Intercollegiate Guidelines Network (SIGN) recommendations.
  • Medford AR et al: Management of spontaneous pneumothorax compared to British Thoracic Society (BTS) 2003 guidelines: a district general hospital audit.
  • Godbole G et al: Management of hepatitis B in pregnant women and infants: a multicentre audit from four London hospitals.
  • Shum S et al: An audit of pain management following pediatric day surgery at British Columbia Children's Hospital.
  • Mathai E et al: Audit of management of pregnant women with positive VDRL tests.
  • Backx M et al: British HIV Association national audit on the management of patients co-infected with tuberculosis and HIV.
  • Beard D et al: National audit of the management of injured patients in 20 Scottish hospitals.
  • Garvey L et al: The British HIV Association national audit on the management of subjects co-infected with HIV and hepatitis B/C.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707407584.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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23. Kang-Birken SL, Castel U, Prichard JG: Oral doxycycline for treatment of neurosyphilis in two patients infected with human immunodeficiency virus. Pharmacotherapy; 2010 Apr;30(4):119e-22e
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The first patient was a 45-year-old Hispanic man with well-suppressed HIV RNA who had a positive Venereal Disease Research Laboratory (VDRL) titer of 1:128.
  • His cerebral spinal fluid (CSF) revealed a positive VDRL titer of 1:16, and an elevated white blood cell count of 96 cells/mm(3) and protein level of 89 mg/dl.
  • Two months later, his CSF VDRL titer, white blood cell count, and protein level decreased to 1:4, 5 cells/mm(3), and 60 mg/dl, respectively.
  • The second patient was a 37-year-old Caucasian man with complications from acquired immunodeficiency disease.
  • A routine VDRL titer was found to be 1:64.
  • Although the CSF VDRL was nonreactive, both his white blood cell count and protein level were elevated at 29 cells/mm(3) and 46 mg/dl, respectively.
  • Three months later, the patient's VDRL titer decreased to 1:2; his CSF white blood cell count decreased significantly to 1 cell/mm(3), and his protein level was within normal limits.


24. Kuliash GIu, Sabaev MI, Erko LV, Mardanly SG, Bakhilina NV: [About effectiveness and perspective of application of test of venereal disease research laboratory (VDRL) for diagnostic of neurosyphilis in the Russian Federation]. Klin Lab Diagn; 2013 Mar;(3):30-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [About effectiveness and perspective of application of test of venereal disease research laboratory (VDRL) for diagnostic of neurosyphilis in the Russian Federation].
  • The liquor from 100 patients with syphilis was analyzed using Bordet-Gengou test, VDRL test and micro-precipitation reaction with cardiolipin antigen.
  • The Bordet-Gengou test and VDRL test made in Russia or abroad are equally effective in analysis of positive samples of liquor and twice surpass the same capacity of micro-precipitation reaction with cardiolipin antigen in case of neurosyphilis with symptoms and thrice surpass in case of asymptomatic neurosyphilis.
  • VDRL test is a simple standardized nontreponema reaction which can substitute labor-consuming non-unified liquorologic complex in laboratory diagnostic of neurosyphilis.
  • The testing of liquor on the basis of micro-precipitation reaction with cardiolipin antigen is non-effective and results in false negative results in Bordet-Gengou and VDRL positive tests determining high risk of erroneous clinical considerations.
  • [MeSH-minor] Adult. Aged. Antibodies, Bacterial / diagnostic use. Antibodies, Bacterial / immunology. Cardiolipins / diagnostic use. Cardiolipins / immunology. Clinical Laboratory Techniques. Female. Humans. Male. Middle Aged. Russia. Treponema pallidum / immunology. Treponema pallidum / isolation & purification. Young Adult

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  • (PMID = 23808023.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Cardiolipins
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25. Nayak S, Acharjya B: VDRL test and its interpretation. Indian J Dermatol; 2012 Jan;57(1):3-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] VDRL test and its interpretation.
  • Venereal disease research laboratory (VDRL) test is a nontreponemal test, used for screening of syphilis due to its simplicity, sensitivity and low cost.
  • Prozone phenomenon and biological false positive (BFP) reaction are two shortcomings of this test.
  • Quantitative estimation of VDRL is essential in treatment evaluation.
  • CSF VDRL test is very specific for neurosyphilis though its sensitivity is low.
  • Interpretation of VDRL in HIV infection is incompletely understood.

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  • (PMID = 22470199.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3312652
  • [Keywords] NOTNLM ; Prozone phenomenon / VDRL / syphilis
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26. Franken AA, Oliver JH, Litwin CM: Comparison of a combined nontreponemal (VDRL) and treponemal immunoblot to traditional nontreponemal and treponemal assays. J Clin Lab Anal; 2015 Jan;29(1):68-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of a combined nontreponemal (VDRL) and treponemal immunoblot to traditional nontreponemal and treponemal assays.
  • METHODS: A commercial IgM/IgG immunoblot assay that detects both nontreponemal (VDRL-Venereal Disease Research Laboratory) and treponemal antibodies was compared with standard nontreponemal and treponemal assays.
  • Ninety-seven samples were Rapid plasma reagin (RPR)-positive and one hundred one were RPR-negative.
  • Positive RPR samples were titered by VDRL.
  • RESULTS: The agreement, sensitivity, and specificity of the IgM/IgG VDRL results of the immunoblot compared to RPR were 74.2% (95% CI: 67.2-80.2), 77.3% (95% CI: 70.2-83.4), and 71.3% (95% CI: 64.4-77.1), respectively.

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  • [Copyright] © 2014 Wiley Periodicals, Inc.
  • (PMID = 24390867.001).
  • [ISSN] 1098-2825
  • [Journal-full-title] Journal of clinical laboratory analysis
  • [ISO-abbreviation] J. Clin. Lab. Anal.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Keywords] NOTNLM ; RPR / immunoblot / nontreponemal / syphilis / treponemal
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27. Cooper IF, Siadaty MS: 'Quantitative Concepts' associated with 'Vdrl Test': Top Publications. BioMedLib Review; QuantitativeConcept;VdrlTest:706104218. ISSN: 2331-5717. 2014/6/22
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  • [Title] 'Quantitative Concepts' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Quantitative Concept' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Quantitative Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 19 publications, and group two 1211 publications.
  • Here are the top 10.
  • Luger A et al: Quantitative evaluation of the FTA-ABS-IgM and VDRL test in treated and untreated syphilis.
  • Pope V et al: Replacement for 30-milliliter flat-bottomed, glass-stoppered, round bottles used in VDRL antigen preparation.
  • FUGAZZOTTO P: Reactivity of VDRL antigen suspensions made at various temperatures.
  • D'Costa JF et al: The effect of environmental temperature on the reactivity of the VDRL slide test.
  • Capoccia A et al: [Serologic study on the prevalence of HIV, HBV infection and on the false positive reaction of VDRL at a prison].
  • Fernandez D et al: A comparative quantitative evaluation of VDRL and Treponema pallidum haemagglutination tests.
  • KIMBALL AC et al: Advantages and limitations of the quantitative VDRL slide test.
  • Harxhi A et al: Multiple ulcers in primary syphilis with negative rapid plasma reagin and Venereal Disease Research Laboratory tests: an unusual presentation during the re-emergence of syphilis in Albania.
  • TANNEN J: Modification of the VDRL test for syphilis; test based on the use of micro amounts of blood.
  • TANNEN J: Modification of the VDRL test for syphilis; test based on the use of micro amounts of blood.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706104218.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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28. Cooper IF, Siadaty MS: 'Immunologic Factors' associated with 'Vdrl Test': Top Publications. BioMedLib Review; ImmunologicFactor;VdrlTest:706222029. ISSN: 2331-5717. 2014/5/24
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  • [Title] 'Immunologic Factors' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Immunologic Factor' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Immunologic Factor'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 1133 publications.
  • Here are the top 10.
  • Pope V et al: Replacement for 30-milliliter flat-bottomed, glass-stoppered, round bottles used in VDRL antigen preparation.
  • Pedersen NS et al: Enzyme-linked immunosorbent assay for detection of antibodies to the venereal disease research laboratory (VDRL) antigen in syphilis.
  • DICKMAN A: Experience with VDRL flocculation antigen in the Kolmer complement fixation test.
  • Simon RD et al: Comparison between the automated reagin test and reagin screen test methods of VDRL screening tests for syphilis in use in a routine laboratory.
  • Marra CM et al: The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.
  • Dorwart BB et al: Comparison of rapid plasma reagin card test and venereal disease research laboratory test in the detection of biological false positive reactions in systemic lupus erythematosus.
  • Thakur TS et al: Seroprevalence of HIV antibodies, Australia antigen and VDRL reactivity in Himachal Pradesh.
  • Sebastian VJ et al: Hepatitis-B surface antigen and VDRL in healthy blood donors of Brunei Darussalam.
  • Tuna I: [Kolmer's complement fixation and VDRL tests].
  • Phaosavasdi S et al: Rapid Plasma Reagin test (RPR) compared to Venereal Diseases Research Laboratory test (VDRL) for the diagnosis of syphilis in pregnancy.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706222029.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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29. Cooper IF, Siadaty MS: 'Amino AcidsCMMA PeptidesCMMA or Proteins' associated with 'Vdrl Test': Top Publications. BioMedLib Review; AminoAcidPeptide;VdrlTest:705636005. ISSN: 2331-5717. 2014/3/22
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  • [Title] 'Amino AcidsCMMA PeptidesCMMA or Proteins' associated with 'Vdrl Test': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Amino Acid Peptide or Protein' for 'vdrl test'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Amino Acid Peptide or Protein'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 18 publications, and group two 1110 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Amino Acids, Peptides, or Proteins' associated with 'Vdrl Test': Top Publications.
  • DICKMAN A: Experience with VDRL flocculation antigen in the Kolmer complement fixation test.
  • Simon RD et al: Comparison between the automated reagin test and reagin screen test methods of VDRL screening tests for syphilis in use in a routine laboratory.
  • Marra CM et al: The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.
  • Dorwart BB et al: Comparison of rapid plasma reagin card test and venereal disease research laboratory test in the detection of biological false positive reactions in systemic lupus erythematosus.
  • Thakur TS et al: Seroprevalence of HIV antibodies, Australia antigen and VDRL reactivity in Himachal Pradesh.
  • Tuna I: [Kolmer's complement fixation and VDRL tests].
  • Phaosavasdi S et al: Rapid Plasma Reagin test (RPR) compared to Venereal Diseases Research Laboratory test (VDRL) for the diagnosis of syphilis in pregnancy.
  • Castro R et al: Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests.
  • Stevens RW et al: The automated reagin test: results compared with VDRL and FTA-ABS tests.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705636005.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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30. Cooper IF, Siadaty MS: 'Manufactured Objects' associated with 'Positive Control': Top Publications. BioMedLib Review; ManufacturedObject;PositiveControl:706236811. ISSN: 2331-5717. 2014/11/24
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  • [Title] 'Manufactured Objects' associated with 'Positive Control': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Manufactured Object' for 'positive control'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Manufactured Object'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 37 publications, and group two 197182 publications.
  • Here are the top 10.
  • Cooper IF et al: 'Steroids' associated with 'Positive Control': Top Publications.
  • Ledent C et al: Positive control of proliferation by the cyclic AMP cascade: an oncogenic mechanism of hyper-functional adenoma.
  • Alberola-Ila J et al: The Ras/MAPK cascade and the control of positive selection.
  • Xu WG et al: [Randomized control study on domestic fixed-dose combinations in the initial treatment of smears positive tuberculosis].
  • Van Wijk EP et al: Behavioural control by simultaneous and serial features in feature-positive and feature-negative discriminations.
  • Kane KA et al: VirB-mediated positive feedback control of the virulence gene regulatory cascade of Shigella flexneri.
  • Wang X et al: Quantitative quality control in microarray experiments and the application in data filtering, normalization and false positive rate prediction.
  • El Naggar NK et al: Switching from biphasic human insulin 30 to biphasic insulin aspart 30 in type 2 diabetes is associated with improved glycaemic control and a positive safety profile: results from the A₁chieve study.
  • Mola GD et al: A case-control study of VDRL-positive antenatal clinic attenders at the Port Moresby General Hospital Antenatal Clinic and Labour Ward to determine outcomes, sociodemographic features and associated risk factors.
  • Tonnelier JM et al: Noninvasive continuous positive airway pressure ventilation using a new helmet interface: a case-control prospective pilot study.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706236811.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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31. Kayal AK, Goswami M, Das M, Paul B: Clinical spectrum of neurosyphilis in North East India. Neurol India; 2011 May-Jun;59(3):344-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Thirteen patients had positive venereal disease research laboratory test (VDRL) and/or high Treponema pallidum hemagglutination titer in blood.
  • Cerebrospinal fluid was positive for VDRL in 14 patients, raised protein was seen in 13 patients and lymphocytic pleocytosis was seen in 10 patients.
  • [MeSH-minor] Adult. Anti-Bacterial Agents / therapeutic use. Brain / pathology. Cardiolipins / analysis. Cholesterol / analysis. Female. Humans. India / epidemiology. Magnetic Resonance Imaging. Male. Mental Disorders / etiology. Middle Aged. Motor Neuron Disease / etiology. Myelitis / etiology. Penicillin G Procaine / therapeutic use. Phosphatidylcholines / analysis. Prospective Studies. Risk-Taking. Spinal Cord / pathology. Substance-Related Disorders / complications. Treponema pallidum. Young Adult

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  • [CommentIn] Neurol India. 2011 Sep-Oct;59(5):794-5; author reply 795 [22019688.001]
  • (PMID = 21743160.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cardiolipins; 0 / Phosphatidylcholines; 0 / VDRL antigen; 17R794ESYN / Penicillin G Procaine; 97C5T2UQ7J / Cholesterol
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32. Nurfahzura MJ, Hanizasurana H, Zunaina E, Adil H: Successful treatment of syphilitic uveitis in HIV-positive patients. Clin Ophthalmol; 2013;7:1651-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of syphilitic uveitis in HIV-positive patients.
  • We report successful treatment of syphilitic uveitis in a case series of three Human immunodeficiency virus (HIV)-positive patients at Malaysia's Selayang Hospital eye clinic.
  • Each patient showed a high Venereal Disease Research Laboratory (VDRL) titer at presentation and they were also newly diagnosed as HIV positive with variable CD4 counts.
  • At 3 months posttreatment, there was reduction in VDRL titer with improvement of vision in the affected eye.
  • All syphilitic uveitis cases should have HIV screening and vice versa, as syphilis is one of the most common infectious diseases associated with HIV-positive patients.

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  • (PMID = 23986629.001).
  • [ISSN] 1177-5467
  • [Journal-full-title] Clinical ophthalmology (Auckland, N.Z.)
  • [ISO-abbreviation] Clin Ophthalmol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3754817
  • [Keywords] NOTNLM ; HIV-positive patient / neurosyphilis / penicillin / syphilitic uveitis
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33. Vincentelli C, Schniederjan MJ, Brat DJ: 35-year-old HIV-positive woman with Basal forebrain mass. Brain Pathol; 2010 Jan;20(1):265-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] 35-year-old HIV-positive woman with Basal forebrain mass.
  • VDRL was non-reactive.
  • Immunohistochemistry was strongly positive for adenovirus and negative for HSV, CMV, SV40 and EBV.


34. Tafuri S, Prato R, Martinelli D, Melpignano L, De Palma M, Quarto M, Germinario C: Prevalence of Hepatitis B, C, HIV and syphilis markers among refugees in Bari, Italy. BMC Infect Dis; 2010;10:213
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The aim of this study was to assess the prevalence of Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) serological markers and the prevalence of VDRL positive subjects in a population of refugees of various nationalities, living in the Asylum Seeker Centre in Bari Palese, Southern Italy.
  • VDRL syphilis screening was also carried out on the serum samples.
  • Of these, 510 were from Africa and 19 from Asia.Forty-four individuals (8.3%) were HBsAg positive and 241 (45.6%) were anti-HBc positive.
  • A total of 24 (4.5%) individuals were anti-HCV positive.
  • Eight asylum seekers (1.5%) were HIV positive.
  • VDRL tests were performed on 269 subjects and 4 (1.5%) were positive.


35. González-Duarte A, López ZM: Neurological Findings in Early Syphilis: a Comparison Between HIV Positive and Negative Patients. Neurol Int; 2013;5(4):e19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurological Findings in Early Syphilis: a Comparison Between HIV Positive and Negative Patients.
  • Twelve patients (75%) were HIV positive; stage was B2 in 2 patients, B3 and C2 in one patient each, and C3 in 8 patients.
  • High venereal disease research laboratory test (VDRL) titers in serum and cerebrospinal fluid (CSF) were found.
  • Disease onset was earlier in patients older than 50 years old with HIV (P=0.049).
  • CSF VDRL continues to be a crucial test in all idiopathic cases of meningitis, stroke and uveitis, regardless of the HIV status or CSF pleocytosis.
  • Except for less pleocytosis, there were no important differences between HIV positive and HIV negative patients.

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  • (PMID = 24416483.001).
  • [ISSN] 2035-8385
  • [Journal-full-title] Neurology international
  • [ISO-abbreviation] Neurol Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3883064
  • [Keywords] NOTNLM ; HIV / infectious stroke / neurosyphilis / ocular syphilis
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36. Naesens R, Vermeiren S, Van Schaeren J, Jeurissen A: False positive Lyme serology due to syphilis: report of 6 cases and review of the literature. Acta Clin Belg; 2011 Jan-Feb;66(1):58-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] False positive Lyme serology due to syphilis: report of 6 cases and review of the literature.
  • VDRL and TPPA testing was positive, and finally, the diagnosis of neurosyphilis was established.
  • We subsequently screened our database on patients with positive VIDAS Lyme screening and negative confirmatory testing by Western blot, and found another 5 cases in which Lyme screening was false positive due to cross-reactivity with Treponema pallidum antibodies.
  • Our data show that in patients with positive Lyme screening and negative confirmatory testing, performance of lues serology should be considered.
  • [MeSH-minor] Adult. Cross Reactions. False Positive Reactions. Humans. Male. Serologic Tests. Syphilis Serodiagnosis / methods

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  • [CommentIn] Acta Clin Belg. 2012 Jan-Feb;67(1):56; author reply 57 [22480045.001]
  • (PMID = 21485767.001).
  • [ISSN] 1784-3286
  • [Journal-full-title] Acta clinica Belgica
  • [ISO-abbreviation] Acta Clin Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
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37. Cordato DJ, Djekic S, Taneja SR, Maley M, Beran RG, Cappelen-Smith C, Griffith NC, Hanna IY, Hodgkinson SJ, Worthington JM, McDougall AJ: Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09). J Clin Neurosci; 2013 Jul;20(7):943-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevalence of positive syphilis serology and meningovascular neurosyphilis in patients admitted with stroke and TIA from a culturally diverse population (2005-09).
  • The study aims were to determine the prevalence of positive syphilis serology and meningovascular neurosyphilis (NS) in patients admitted with transient ischaemic attack (TIA) and stroke to a tertiary hospital serving a culturally diverse community.
  • A retrospective cohort analysis was conducted using routinely collected administrative data and medical records to identify patients admitted with TIA, stroke and other conditions, with positive syphilis serology, between 2005 and 2009.
  • Syphilis serology was requested in 27% (893/3270) of all patients with TIA and stroke (2005-09) of whom 4% (38/893) were positive.
  • Thirty-seven patients with positive serology had clinical characteristics consistent with meningovascular NS.
  • One of 12 patients with suspected meningovascular NS with cerebrospinal fluid (CSF) analysis had a positive CSF Venereal Disease Research Laboratory (VDRL) test.
  • All three patients with a "definite or probable" meningovascular NS and 15 (44%) of the remainder who had positive serology without confirmation of NS were treated with intravenous or intramuscular penicillin.
  • Lumbar puncture (LP) and penicillin were underutilised in patients with TIA and stroke with positive serology.
  • In patients with TIA and stroke with positive syphilis serology, it would seem appropriate to further pursue diagnosis and treatment and in patients unable to undergo LP, empiric treatment for NS should be considered.


38. Vasudevan B, Verma R, Pragasam V, Badad A, Mitra D, Singh V: A rare case of secondary syphilis manifesting as immune reconstitution syndrome in an HIV-positive patient. J Int Assoc Provid AIDS Care; 2013 Nov-Dec;12(6):380-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of secondary syphilis manifesting as immune reconstitution syndrome in an HIV-positive patient.
  • He showed a positive sign of Buschke-Ollendorff.
  • Serum venereal disease research laboratory (VDRL) test was reactor at 1:64.
  • He was found to be positive result for treponema pallidum hemagglutination test.
  • The rash responded well to a single injection of benzathine penicillin, resulting in the lowering of the VDRL titers.
  • This is a very rare instance of secondary syphilis manifesting as immune reconstitution syndrome in an HIV-positive patient.


39. Kyebambe PS: Neurosyphilis masquerading as hemiparesis and Jacksonian epilepsy in an HIV positive patient: a case report. Afr Health Sci; 2010 Jun;10(2):211-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurosyphilis masquerading as hemiparesis and Jacksonian epilepsy in an HIV positive patient: a case report.
  • BACKGROUND: Neurosyphilis is a common but often missed disease worldwide, mainly because it has many manifestations making its diagnosis difficult.
  • OBJECTIVES: To describe one of our cases of neurosyphilis in HIV, raise awareness about the reality of neurosyphilis in Africa and share our experiences in diagnosis and management of the disease.
  • METHODS: A 40 year old, HIV positive female was admitted with a 2 month history of left sided facial and limb weakness followed by delirium, aphasia and Jacksonian epilepsy.
  • She underwent clinical and laboratory evaluation.
  • The VDRL on the CSF was positive.


40. Maity S, Bhunia SC, Biswas S, Saha MK: Syphilis seroprevalence among patients attending a sexually transmitted disease clinic in West Bengal, India. Jpn J Infect Dis; 2011;64(6):506-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Syphilis seroprevalence among patients attending a sexually transmitted disease clinic in West Bengal, India.
  • Syphilis is a sexually transmitted disease (STD) and is a major public health concern in India.
  • Blood samples were collected from 250 consecutive patients per year (a total of 1,250 samples over 5 years); the patients attended the STD clinic for 12 weeks (October-December) each year, and the serostatus of syphilis was determined qualitatively with the Venereal Disease Research Laboratory (VDRL) test using serum samples.
  • A quantitative VDRL test was then performed at a dilution of 1:8 using serum samples that yielded positive results in the qualitative VDRL test.
  • Finally, serum samples that yielded positive results in the quantitative VDRL test were also subjected to the Treponema pallidum hemagglutination assay (TPHA).
  • The serum samples that yielded positive results in both the tests were considered syphilis seropositive.
  • All seropositive serum samples from the quantitative VDRL test were also found to be positive results in TPHA.

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  • (PMID = 22116330.001).
  • [ISSN] 1884-2836
  • [Journal-full-title] Japanese journal of infectious diseases
  • [ISO-abbreviation] Jpn. J. Infect. Dis.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Cardiolipins; 0 / Phosphatidylcholines; 0 / VDRL antigen; 97C5T2UQ7J / Cholesterol
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41. Vaideeswar P: Syphilitic aortitis: rearing of the ugly head. Indian J Pathol Microbiol; 2010 Oct-Dec;53(4):624-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Syphilitic aortitis has been relegated to the category of rare cardiovascular disease or a "medical curiosity" in the west.
  • They were predominantly seen in males in the fifth decade, who often presented with valvular regurgitation, aneurysmal disease or myocardial ischemia; 13.6 % of patients were asymptomatic.
  • Blood VDRL results were available in 19 patients; 84.2 % were positive.

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  • (PMID = 21045381.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Cardiolipins; 0 / Phosphatidylcholines; 0 / VDRL antigen; 97C5T2UQ7J / Cholesterol
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42. Gu X, Guan Z, Chai Z, Zhou P: Unilateral mydriasis as the primary sign of neurosyphilis. Infection; 2014 Feb;42(1):215-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient met the criteria for the diagnosis of neurosyphilis by the finding of positive cerebrospinal fluid-Venereal Disease Research Laboratory (CSF-VDRL) and CSF-Treponema pallidum particle agglutination tests.
  • The CSF-VDRL test was negative.
  • It is highly recommended that any patients with ocular disease that does not respond to the routine treatment should undergo syphilis evaluation to avoid misdiagnosis.

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  • (PMID = 23900772.001).
  • [ISSN] 1439-0973
  • [Journal-full-title] Infection
  • [ISO-abbreviation] Infection
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Cardiolipins; 0 / Phosphatidylcholines; 0 / VDRL antigen; 75J73V1629 / Ceftriaxone; 97C5T2UQ7J / Cholesterol
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43. Vulcano F, Milazzo L, Volpi S, Battista MM, Barca A, Hassan HJ, Pimpinelli F, Giampaolo A: Italian national survey of blood donors: external quality assessment (EQA) of syphilis testing. J Clin Microbiol; 2010 Mar;48(3):753-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Each panel consisted of both positive and negative serum samples.
  • The results confirmed that the use of a single nontreponemal test (the Venereal Disease Research Laboratory [VDRL] and the rapid plasma reagin [RPR] tests) is the least sensitive means of identifying samples that are positive for syphilis antibodies.
  • We also found that the interpretation of the results of manual techniques, such as the RPR test, the VDRL test, the Treponema pallidum hemagglutination (TPHA) assay, and the T. pallidum particle agglutination (TPPA) assay, can vary greatly among different TSs and operators.
  • However, the determination of syphilis on the basis of the results of a single test is not sufficient for an accurate screening; and all blood units should thus be assessed by two distinct treponemal tests, that is, a total Ig EIA and the TPHA or the TPPA assay.
  • [MeSH-major] Bacteriological Techniques / standards. Health Services Research. Syphilis / diagnosis. Syphilis / transmission. Treponema pallidum / isolation & purification

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  • HSDB. structure - CHOLESTEROL.
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  • (PMID = 20042617.001).
  • [ISSN] 1098-660X
  • [Journal-full-title] Journal of clinical microbiology
  • [ISO-abbreviation] J. Clin. Microbiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Bacterial; 0 / Cardiolipins; 0 / Immunoglobulin G; 0 / Phosphatidylcholines; 0 / Reagins; 0 / VDRL antigen; 97C5T2UQ7J / Cholesterol
  • [Other-IDs] NLM/ PMC2832432
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44. Hussain Laghari A, Sultana V, Hussain Samoo A, Makhija P, Ara J, Hira: Prevalence and associated risk factors for syphilis in women with recurrent miscarriages. Pak J Med Sci; 2014 Mar;30(2):295-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were collected by all women answered a questionnaire and by investigating blood sample VDRL test and FTA-ABS test.
  • Out of the 256 samples, 05 (1.9%) were positive for active syphilis.

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  • (PMID = 24772130.001).
  • [ISSN] 1682-024X
  • [Journal-full-title] Pakistan journal of medical sciences
  • [ISO-abbreviation] Pak J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
  • [Other-IDs] NLM/ PMC3998997
  • [Keywords] NOTNLM ; FTA-ABS / Recurrent miscarriages / Syphilis / Treponema Pallidum infection / VDRL
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45. Naha K, Vivek G, Dasari S, Manthappa M, Dias L, Acharya R: An unusual cause for hyponatremia with seizures. BMJ Case Rep; 2012;2012
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical examination and basic laboratory parameters were entirely normal except for significant hyponatremia.
  • Screening for a chronic meningitis underlying SIADH, yielded positive blood and CSF titres for venereal disease research laboratory (VDRL), which were confirmed by Treponema pallidum haemagglutination (TPHA).
  • On follow-up, she remained TPHA positive but VDRL titres became negative.

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  • (PMID = 22605698.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3316798
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46. Kim GH, Kim BU, Lee JH, Choi YH, Chae HB, Park SM, Youn SJ, Lee JY, Yoon TY, Sung R: Cholestatic hepatitis and thrombocytosis in a secondary syphilis patient. J Korean Med Sci; 2010 Nov;25(11):1661-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Laboratory findings suggested an acute hepatitis and thrombocytosis.
  • Serologic test results were positive for VDRL.
  • [MeSH-minor] Acute Disease. Adult. Alkaline Phosphatase / blood. Bilirubin / blood. Epidermis / pathology. Humans. Jaundice. Male. Penicillin G Benzathine / therapeutic use. Syphilis Serodiagnosis. Tomography, X-Ray Computed

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  • (PMID = 21060758.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] EC 3.1.3.1 / Alkaline Phosphatase; RFM9X3LJ49 / Bilirubin; RIT82F58GK / Penicillin G Benzathine
  • [Other-IDs] NLM/ PMC2967006
  • [Keywords] NOTNLM ; Hepatitis / Syphilis, Cutaneous / Thrombocytosis
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47. Sanhueza D, Ramírez E, Navarrete N, Santander E, Garmendia ML, Martínez MJ: [Human T-lymphotropic virus I/II detection in Chilean patients from Sexually Transmitted Diseases clinics]. Rev Med Chil; 2012 Oct;140(10):1239-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Only one of the 200 samples was positive (0.5%) and it came from a 70 year-old woman, housewife, with a stable single partner, a history of recurrent genital ulcers, VDRL (-) and positive serology for herpes simplex virus.

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  • (PMID = 23559279.001).
  • [ISSN] 0717-6163
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Chile
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48. Del Boccio M, Lobefalo L, Pennelli A, Toniato E, Martinotti S, Tenaglia R, Neri G, Del Boccio G, Gallenga PE: Can latent synergism of intestinal pathogens be responsible for inflammaging process causing Reiter's syndrome in a young patient HLA-B27 infected by atypical pathogens? A holistic view and clinical biochemical reinterpretation. J Biol Regul Homeost Agents; 2012 Oct-Dec;26(4):741-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • VDRL, Lupus anti-coagulant (LAC) and Widal-Wright (WWR), resulted positive.
  • The antibodies (IgG/IgA anti-Ct) against chronic Chlamydia trachomatis inflammation were positive.
  • Parasitological research and digestibility test were performed, resulting a latent chronic bowel inflammation, including certain enteroinvasive pathogens, such as, Salmonella, Shigella, Yersinia and Campylobacter (Enteric Pathogens Group, EPG) and Escherichia Coli pathogens (Escherichia Coli Pathogens Group, ECPG).
  • The Salmonella typhi-DNA resulted positive, while 90% of the total microbic charge (TMC) was represented by C. freundi in culture analyses.
  • Interpreting the VDRL positive test as early triggering of autoimmune disease, a few acute phase proteins as a pauci-symptomatic chronic phlogistic process, the amylase and alkaline phosphatase alterations as tissue markers of early intestinal inflammation, the Widal's reaction positivity together with the precocious clinical and faecal manifestations, this study suggests the prime triggering role of these atypical pathogens to cause a chronic low grade autoimmune response against the tissue/organ susceptible target, causing inflammaging phenomenon in young patient with chronic latent infection by Salmonella typhi, leading to Reiter's syndrome, in HLA-B27 positive patient.

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  • (PMID = 23241124.001).
  • [ISSN] 0393-974X
  • [Journal-full-title] Journal of biological regulators and homeostatic agents
  • [ISO-abbreviation] J. Biol. Regul. Homeost. Agents
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / HLA-B27 Antigen; 0 / Immunosuppressive Agents
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49. Benzaken AS, Sabidó M, Galban E, Pedroza V, Araújo AJ, Peeling RW, Mabey D: Field performance of a rapid point-of-care diagnostic test for antenatal syphilis screening in the Amazon region, Brazil. Int J STD AIDS; 2011 Jan;22(1):15-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Field performance of a rapid point-of-care diagnostic test for antenatal syphilis screening in the Amazon region, Brazil.
  • We evaluated an immunochromatographic point-of-care (POC) syphilis test in 712 pregnant women under field conditions in remote communities of the Amazon region (Brazil), and identified risk factors for syphilis.
  • Women were screened by POC test using whole blood obtained by fingerprick, the fluorescent treponemal antibody absorption (FTA-Abs) test as the gold standard and the Venereal Diseases Research Laboratory (VDRL) test to determine test performance in active syphilis.
  • Among women, 2.2% had syphilis (positive FTA-Abs) and 0.8% active syphilis (FTA-Abs and VDRL positive).
  • In all, 2.2% of samples were positive by the POC test.
  • The sensitivity, specificity, positive and negative predictive values were 62.5% (95% confidence interval [CI]: 38.6-81.5), 99.1% (95% CI: 98.1-99.6), 62.5% (95% CI: 38.6-81.5) and 99.1% (95% CI: 98.1-99.6), respectively.
  • The POC test identified 62.5% (10/16) of syphilis cases, 66.7% (4/6) of active syphilis cases and all high-titre syphilis cases (VDRL > 1:8).
  • The rapid test performed moderately well as a screening tool for low-risk populations.


50. Punia V, Rayi A, Sivaraju A: Stroke after Initiating IV Penicillin for Neurosyphilis: A Possible Jarisch-Herxheimer Reaction. Case Rep Neurol Med; 2014;2014:548179
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Serum RPR test was positive and VDRL test in the CSF was reactive.

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  • (PMID = 25431710.001).
  • [ISSN] 2090-6668
  • [Journal-full-title] Case reports in neurological medicine
  • [ISO-abbreviation] Case Rep Neurol Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4238263
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2. Definitions


3. Related RMF webpages
1. positive vdrl
2. positive wassermann
3. gram positive cocci
4. false positive reactions
5. positive pressure respiration
6. positive serology for syphilis
7. gram positive rods
8. gram positive bacteria
9. mantoux positive finding
10. intermittent positive pressure breathing
11. nonspecific positive culture findings
12. pneumonia cold agglutinin positive
13. cholangiography operative positive contrast
14. abnormal urine positive culture
15. positive culture findings in nose
16. positive culture findings in sputum
17. positive culture findings in wound
18. gram positive cocci meningitis
19. hpv dna test positive
20. invasive positive pressure ventilation
21. inspiratory positive pressure ventilation
22. breathing intermittent positive pressure
23. cd4 positive t lymphocytes
24. cd8 positive t lymphocytes
25. gram positive asporogenous rods
26. gram positive bacterial infections
27. positive pressure respiration intrinsic
28. continuous positive airway pressure
29. intermittent positive pressure ventilation
30. non invasive positive pressure nippv
31. gram positive endospore forming bacteria
32. estrogen receptor positive status er
33. gram positive endospore forming rods
34. positive transcriptional elongation factor b
35. gram positive asporogenous rods irregular
36. positive culture findings in throat situation
37. gram positive asporogenous rods regular
38. t lymphocytopenia idiopathic cd4 positive
39. pregnancy examination or test positive result
40. leukemia myelogenous chronic bcr abl positive
41. bi level positive airway pressure bipap
42. vaginal low risk hpv dna test positive
43. vaginal low risk human papillomavirus dna test positive
44. cervical high risk human papillomavirus hpv dna test positive
45. vaginal high risk human papillomavirus hpv dna test positive
46. asymptomatic hiv hiv test positive

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