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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 50%  Kim GJ, Lee ES: Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus. Korean J Radiol; 2009 Mar-Apr;10(2):190-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus.
  • We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later.
  • Fetal hepatosplenomegaly with cerebral ventriculomegaly, although not specific, may be a suggestive finding of Down syndrome with transient abnormal myelopoiesis.
  • [MeSH-minor] Adult. Female. Fetal Blood / cytology. Fetal Death. Hepatomegaly / ultrasonography. Humans. Leukocytosis / diagnosis. Pregnancy. Splenomegaly / ultrasonography. Thrombocytopenia / diagnosis

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  • (PMID = 19270866.001).
  • [ISSN] 2005-8330
  • [Journal-full-title] Korean journal of radiology : official journal of the Korean Radiological Society
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2651437
  • [Keywords] NOTNLM ; Down syndrome / Hepatosplenomegaly / Transient abnormal myelopoiesis / Ventriculomegaly
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2. |||||..... 50%  Angiolucci M, Murru R, Melis G, Carcassi C, Mais V: Association between different morphological types and abnormal karyotypes in early pregnancy loss. Ultrasound Obstet Gynecol; 2011 Feb;37(2):219-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between different morphological types and abnormal karyotypes in early pregnancy loss.
  • OBJECTIVES: To identify the abnormal transvaginal ultrasound (TVS) findings typical of aneuploidic pregnancies that end with early pregnancy loss (EPL).
  • The proportions of abnormal karyotypes were compared among different groups of EPLs characterized by different morphological features.
  • RESULTS: Six morphological types were identified in EPLs, one normal and five abnormal (small gestational sac, small embryo/fetus, early symmetrical arrested growth, enlarged yolk sac and empty sac).
  • The highest rate of chromosomal abnormalities was observed in the early symmetrical arrested growth group (100%), followed by small embryo/fetus (94.1%), enlarged yolk sac (93.3%) and empty sac (72.2%) groups.
  • The majority of cases of trisomy 22 (92.3%) were in the enlarged yolk sac group and the majority of cases with a 45,X karyotype were in the small embryo/fetus group (77.8%).
  • CONCLUSIONS: There is an association in EPLs between some abnormal karyotypes and some morphological types.
  • The demonstration by TVS of abnormalities in the development of early pregnancy structures could be helpful for predicting aneuploidy in EPLs.
  • [MeSH-major] Abortion, Spontaneous / genetics. Abortion, Spontaneous / ultrasonography. Chromosome Aberrations. Chromosome Disorders / ultrasonography. Pregnancy Complications / ultrasonography
  • [MeSH-minor] Adult. Female. Humans. Italy. Maternal Age. Microsatellite Repeats / genetics. Organ Size. Pregnancy. Pregnancy Trimester, First. Prospective Studies. Ultrasonography, Prenatal. Yolk Sac / pathology. Yolk Sac / ultrasonography

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  • [Copyright] Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 20503243.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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3. |||||..... 48%  Paladini D, Quarantelli M, Pastore G, Sorrentino M, Sglavo G, Nappi C: Abnormal or delayed development of the posterior membranous area of the brain: anatomy, ultrasound diagnosis, natural history and outcome of Blake's pouch cyst in the fetus. Ultrasound Obstet Gynecol; 2012 Mar;39(3):279-87
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abnormal or delayed development of the posterior membranous area of the brain: anatomy, ultrasound diagnosis, natural history and outcome of Blake's pouch cyst in the fetus.
  • OBJECTIVES: To review the normal and pathological development of the posterior membranous area (PMA) in the fetal brain, to define sonographic criteria with which to diagnose a Blake's pouch cyst (BPC) in the fetus and to review the ultrasound features, associations and outcome of 19 cases of BPC seen at our center over the last 5 years.
  • METHODS: We conducted a MEDLINE search using the terms 'Blake's pouch', with or without 'fourth ventricle' or '4(th) ventricle', with or without 'roof' and identified articles describing normal and/or abnormal development of the PMA, whether or not they were cited in the limited clinical literature on BPC.
  • A description of the normal and abnormal development of BPC was derived by collating these articles.
  • The following variables were assessed: referral indication, gestational age at diagnosis, ultrasound and magnetic resonance imaging (MRI) findings, associated anomalies, natural history and pregnancy and neonatal outcome.
  • On follow-up, the BPC had disappeared by 24-26 gestational weeks in six of the 11 cases which did not undergo termination of pregnancy (TOP), and remained unaltered until birth in the other five cases.
  • Karyotype was available in 14 cases, two of which were abnormal (both trisomy 21).
  • Regarding pregnancy outcome, there were eight (42%) TOPs, two (10%) neonatal deaths and nine (48%) survivors.
  • CONCLUSIONS: Based on our analysis of ultrasound features, we propose that for BPC to be diagnosed in a fetus the following three criteria should be fulfilled:.
  • [MeSH-minor] Female. Gestational Age. Humans. Infant, Newborn. Karyotype. Pregnancy. Prognosis. Retrospective Studies

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  • [Copyright] Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 22081472.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] Dandy Walker cyst
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4. ||||...... 40%  Cooper IF, Siadaty MS: 'Congenital Abnormalities' associated with 'Abnormal Fetus': Top Publications. BioMedLib Review; CongenitalAbnormality;AbnormalFetus:706637368. ISSN: 2331-5717. 2014/5/29
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  • [Title] 'Congenital Abnormalities' associated with 'Abnormal Fetus': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Congenital Abnormality' for 'abnormal fetus'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Congenital Abnormality'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications, and group two 2677 publications.
  • Here are the top 10.
  • Martínez Crespo JM et al: Prenatal diagnosis of hypoplastic left heart syndrome and trisomy 18 in a fetus with normal nuchal translucency and abnormal ductus venosus blood flow at 13 weeks of gestation.
  • Hamada H et al: Hypoechoic hepatomegaly associated with transient abnormal myelopoiesis provides clues to trisomy 21 in the third-trimester fetus.
  • Kim GJ et al: Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus.
  • Hashimoto K et al: Harlequin fetus with abnormal lamellar granules and giant mitochondria.
  • Croonen EA et al: Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings.
  • Hyett J et al: Abnormalities of the heart and great arteries in first trimester chromosomally abnormal fetuses.
  • Lee KA et al: PTPN11 analysis for the prenatal diagnosis of Noonan syndrome in fetuses with abnormal ultrasound findings.
  • Dolan CR et al: Prenatal detection of epidermolysis bullosa letalis with pyloric atresia in a fetus by abnormal ultrasound and elevated alpha-fetoprotein.
  • Hiroi H et al: A fetus with Prader-Willi syndrome showing normal diurnal rhythm and abnormal ultradian rhythm on heart rate monitoring.
  • Chen CP et al: Monozygotic twins with trisomy 18 of paternal origin: prenatal diagnosis and molecular cytogenetic characterization in a pregnancy with one structurally abnormal living fetus and one intrauterine fetal demise.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 706637368.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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5. ||||...... 45%  O'Neill E, Thorp J: Antepartum evaluation of the fetus and fetal well being. Clin Obstet Gynecol; 2012 Sep;55(3):722-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Antepartum evaluation of the fetus and fetal well being.
  • When confronted with an abnormal test, clinicians should evaluate with a second antenatal test and consider administering betamethasone, performing amniocentesis to assess lung maturity, and/or repeating testing to minimize the chance of iatrogenic prematurity in case of a healthy fetus.
  • [MeSH-major] Fetus. Prenatal Diagnosis / methods. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Cardiotocography. Female. Fetal Death. Fetal Distress / diagnosis. Fetal Movement. Fetal Organ Maturity. Humans. Lung / embryology. Pregnancy. Pregnancy Complications / diagnosis. Pregnancy Outcome. Pregnancy, High-Risk. Ultrasonography, Doppler

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  • (PMID = 22828105.001).
  • [ISSN] 1532-5520
  • [Journal-full-title] Clinical obstetrics and gynecology
  • [ISO-abbreviation] Clin Obstet Gynecol
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / T32 HD040672
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS473808; NLM/ PMC3684248
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6. ||||...... 44%  Mulder EJ, Ververs FF, de Heus R, Visser GH: Selective serotonin reuptake inhibitors affect neurobehavioral development in the human fetus. Neuropsychopharmacology; 2011 Sep;36(10):1961-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Selective serotonin reuptake inhibitors affect neurobehavioral development in the human fetus.
  • In this observational study we investigated developmental milestones of fetal behavior during the pregnancy of women with psychiatric disorders who took SSRIs throughout gestation (medicated group; n=96) or who had discontinued medication early in gestation or before conception (unmedicated group; n=37).
  • Ultrasonographic observations of fetal behavior were made three times in pregnancy (T1-T3).
  • The SSRI effects on the fetus were dose related, but independent of SSRI type.
  • Bodily activity at high rate during non-REM sleep in SSRI-exposed fetuses is an abnormal phenomenon, but its significance for postnatal development is unclear.
  • [MeSH-major] Fetal Development / drug effects. Fetal Development / physiology. Mental Disorders / drug therapy. Pregnancy Complications / drug therapy. Serotonin Uptake Inhibitors / pharmacology
  • [MeSH-minor] Adult. Dose-Response Relationship, Drug. Female. Humans. Longitudinal Studies. Male. Pregnancy. Prospective Studies


7. |||||..... 46%  Vimercati A, de Gennaro AC, Cobuzzi I, Grasso S, Abruzzese M, Fascilla FD, Cormio G, Selvaggi L: Two cases of complete hydatidiform mole and coexistent live fetus. J Prenat Med; 2013 Jan;7(1):1-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two cases of complete hydatidiform mole and coexistent live fetus.
  • The aim of this study was to report the clinical features, management, and outcome of complete hydatidiform mole with a coexisting viable fetus.
  • In both cases ultrasound examination demonstrated a normally growing live fetus alongside a normal placenta and an additional intrauterine echogenic mass with features of hydatidiform mole.
  • Microscopic examination of the abnormal placentas confirmed complete hydatidiform mole.
  • Continuation of a twin pregnancy with complete hydatidiform mole (CHMF) is an acceptable option.
  • Close surveillance of an ongoing pregnancy is compulsory to detect potential early signs of complications.

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  • (PMID = 23741539.001).
  • [ISSN] 1971-3282
  • [Journal-full-title] Journal of prenatal medicine
  • [ISO-abbreviation] J Prenat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  • [Other-IDs] NLM/ PMC3671816
  • [Keywords] NOTNLM ; complete hydatidiform mole / gestational trophoblastic disease / twin pregnancy
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8. |||||..... 53%  Saemundsson Y, Svantesson H, Gudmundsson S: Abnormal uterine artery Doppler in pregnancies suspected of a SGA fetus is related to increased risk of recurrence during next pregnancy. Acta Obstet Gynecol Scand; 2009;88(7):814-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abnormal uterine artery Doppler in pregnancies suspected of a SGA fetus is related to increased risk of recurrence during next pregnancy.
  • OBJECTIVE: To investigate if placental Doppler velocimetry can predict the recurrence of a small-for-gestational age (SGA) fetus in subsequent pregnancies.
  • METHODS: A total of 196 pregnancies suspected of a SGA fetus (<3rd percentile) evaluated by uterine and umbilical artery Doppler velocimetry.
  • MAIN OUTCOME MEASURE: The occurrence of a SGA newborn during the succeeding pregnancy by Doppler results from the previous pregnancy.
  • RESULTS: In the group of 196 pregnancies suspected for SGA, 27 (13.8%) delivered a SGA newborn in the following pregnancy.
  • Thirty-seven (18.9%) of the 196 had an abnormally high PI in the uterine arteries in their first pregnancy, 12 (32.4%) of these delivered a SGA child in the next pregnancy (relative risk 3.44, p<0.001).
  • Abnormal umbilical artery Doppler was a worse predictor of recurrence of SGA (p=0.051).
  • Uterine artery notching was not related to a SGA newborn during next pregnancy.
  • CONCLUSION: The results suggest that abnormal uterine artery Doppler is related to increased risk of recurrence of SGA during the next pregnancy.
  • This knowledge might provide the clinician with an opportunity to initiate preventive treatment and increase surveillance to women at risk during succeeding pregnancy.
  • [MeSH-minor] Arteries / ultrasonography. Blood Flow Velocity. Female. Humans. Infant, Newborn. Linear Models. Placental Circulation. Predictive Value of Tests. Pregnancy. Pregnancy Outcome. Pregnancy, High-Risk. Recurrence. Retrospective Studies. Risk Factors. Statistics, Nonparametric. Ultrasonography, Doppler


9. |||||..... 53%  Chen CP, Chern SR, Chen YY, Wu PC, Town DD, Chen WL, Wang W: Monozygotic twins with trisomy 18 of paternal origin: prenatal diagnosis and molecular cytogenetic characterization in a pregnancy with one structurally abnormal living fetus and one intrauterine fetal demise. Taiwan J Obstet Gynecol; 2012 Sep;51(3):430-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Monozygotic twins with trisomy 18 of paternal origin: prenatal diagnosis and molecular cytogenetic characterization in a pregnancy with one structurally abnormal living fetus and one intrauterine fetal demise.
  • OBJECTIVE: To present prenatal diagnosis and molecular cytogenetic characterization of trisomy 18 in a monozygotic twin pregnancy, with one structurally abnormal living fetus and one intrauterine fetal demise.
  • Prenatal ultrasound revealed a monozygotic twin pregnancy, with one structurally abnormal living fetus, and one fetal demise.
  • The body structure details of the dead fetus could not be identified, whereas holoprosencephaly and omphalocele were identified in the living fetus on prenatal ultrasound.
  • Quantitative fluorescent polymerase chain reaction assays using polymorphic DNA markers specific for chromosome 21 and chromosome 18, were applied to the uncultured amniocytes in the amniotic cavity of the living fetus and the cultured amniocytes in the amniotic cavity of the fetus with intrauterine fetal demise.
  • The pregnancy was terminated at 19 weeks of gestation, and a 2g small-for-date macerated twin A and a 166g malformed twin B were delivered.
  • [MeSH-minor] Adult. Amniocentesis. Cytogenetic Analysis. Female. Humans. Polymerase Chain Reaction. Pregnancy. Ultrasonography, Prenatal

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  • [Copyright] Copyright © 2012. Published by Elsevier B.V.
  • (PMID = 23040931.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
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10. |||||..... 51%  Kurdi AM, Al-Sasi OM, Asiri SM, Al-Hudhaif JM: Fetus-in-fetu. Imaging and pathology. Saudi Med J; 2012 Apr;33(4):444-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fetus-in-fetu. Imaging and pathology.
  • Fetus-in-fetu (FIF), also known as endoparasitic twin, is a form of asymmetric fetal duplication in which the abnormal developing embryo parasitizes the normal co-twin by attaching internally.
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Ultrasonography, Prenatal

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  • (PMID = 22485242.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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11. |||||..... 46%  Hadden DR, McLaughlin C: Normal and abnormal maternal metabolism during pregnancy. Semin Fetal Neonatal Med; 2009 Apr;14(2):66-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Normal and abnormal maternal metabolism during pregnancy.
  • Metabolic adaptations during pregnancy are essential to meet the physiological demands of pregnancy as well as adequate growth and development of the fetus.
  • There has been considerable interest in carbohydrate metabolism during pregnancy, with diabetes, the main disorder of glucose metabolism, a considerable focus for research.
  • Whereas disorders of protein and lipid metabolism are recognised during pregnancy, their influence has received less attention.
  • Fasting glucose values fall in early pregnancy with a rise in plasma free fatty acids, enhanced ketogenesis and a fall in plasma amino acids.
  • Decreased hepatic insulin sensitivity in later pregnancy plays a key role in bringing about the appropriate changes in carbohydrate, lipid and amino acid metabolism which are essential for normal fetal development and survival.
  • [MeSH-major] Blood Glucose / metabolism. Glucose Intolerance / blood. Pregnancy / blood. Pregnancy Complications / blood

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  • [ErratumIn] Semin Fetal Neonatal Med. 2009 Dec;14(6):401
  • (PMID = 18986856.001).
  • [ISSN] 1744-165X
  • [Journal-full-title] Seminars in fetal & neonatal medicine
  • [ISO-abbreviation] Semin Fetal Neonatal Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Amino Acids; 0 / Blood Glucose
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12. |||||..... 46%  Blanco PG, Rodríguez R, Rube A, Arias DO, Tórtora M, Díaz JD, Gobello C: Doppler ultrasonographic assessment of maternal and fetal blood flow in abnormal canine pregnancy. Anim Reprod Sci; 2011 Jun;126(1-2):130-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Doppler ultrasonographic assessment of maternal and fetal blood flow in abnormal canine pregnancy.
  • The aim of this study was to describe the changes of uterine artery, umbilical artery and fetal abdominal aorta, renal and internal carotid arteries blood flow in abnormal canine pregnancy.
  • Twenty-two, Brucella-negative pregnant bitches were retrospectively classified into abnormal (which had either interrupted their pregnancy between days 52 and 60 or had perinatal death >60% of the litter; n=11) and normal (which had delivered healthy puppies at term; n=11).
  • Throughout the study, resistance index (RI) of uterine, umbilical and fetal renal arteries decreased up to -15% compared to -36% (P<0.01), -11% compared to -23% (P<0.05) and 2% compared to -13% (P<0.05), respectively in the abnormal and normal bitches.
  • It is concluded that in dogs, uterine artery, umbilical artery and fetal renal artery RI differ between normal and abnormal gestation being useful for the prediction of adverse obstetric outcome.
  • [MeSH-major] Fetus / blood supply. Pregnancy, Animal. Ultrasonography, Doppler / veterinary. Ultrasonography, Prenatal / veterinary. Uterine Artery / ultrasonography
  • [MeSH-minor] Abortion, Veterinary. Animals. Animals, Newborn. Aorta, Abdominal / ultrasonography. Dogs. Female. Heart Rate, Fetal. Pregnancy. Renal Artery / ultrasonography

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  • [Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.
  • (PMID = 21616613.001).
  • [ISSN] 1873-2232
  • [Journal-full-title] Animal reproduction science
  • [ISO-abbreviation] Anim. Reprod. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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13. |||||..... 46%  Black LV, Maheshwari A: Disorders of the fetomaternal unit: hematologic manifestations in the fetus and neonate. Semin Perinatol; 2009 Feb;33(1):12-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disorders of the fetomaternal unit: hematologic manifestations in the fetus and neonate.
  • Histoarchitectural characteristics of the human placenta place the fetus at a high risk of growth restriction, abnormal fetomaternal cell traffic, and vertical transmission of pathogens.
  • These abnormalities of the fetomaternal unit are frequently associated with hematological abnormalities in the fetus/neonate and may be the first, most common, or the only clinical manifestations of these conditions.
  • This article reviews the pathophysiology and characteristic hematological manifestations of these conditions in the fetus and the neonate.
  • [MeSH-major] Hematologic Diseases / physiopathology. Placenta / physiopathology. Pregnancy Complications, Hematologic / physiopathology
  • [MeSH-minor] Female. Fetus. Humans. Infant, Newborn. Pregnancy

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  • (PMID = 19167577.001).
  • [ISSN] 1558-075X
  • [Journal-full-title] Seminars in perinatology
  • [ISO-abbreviation] Semin. Perinatol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / R01 HD059142
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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14. |||||..... 46%  Sharma A, Paliwal P, Dadhwal V, Sharma Y, Deka D: Rare finding of 2n/4n mixoploidy in mother and fetus with severe immune hydrops. Cytogenet Genome Res; 2009;124(1):90-3
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  • [Title] Rare finding of 2n/4n mixoploidy in mother and fetus with severe immune hydrops.
  • On rare occasions its presence indicates a chromosomally abnormal fetus with multiple congenital defects.
  • The reported pregnancy also resulted in a fetus with severe hydrops.
  • Cytogenetic analysis of cultured amniotic fluid cells revealed diploid-tetraploid mosaicism in the fetus also confirmed in fetal cord blood and skin fibroblasts.
  • [MeSH-major] Abnormalities, Multiple / genetics. Edema. Fetus / abnormalities. Mosaicism. Ploidies
  • [MeSH-minor] Adult. Amniotic Fluid / cytology. Cells, Cultured. Chromosome Disorders / diagnosis. Chromosome Disorders / genetics. Fatal Outcome. Female. Fetal Blood / cytology. Fibroblasts / cytology. Humans. Infant, Newborn. Karyotyping. Leukocytes, Mononuclear / cytology. Metaphase. Pregnancy. Prenatal Diagnosis. Skin / cytology

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19372673.001).
  • [ISSN] 1424-859X
  • [Journal-full-title] Cytogenetic and genome research
  • [ISO-abbreviation] Cytogenet. Genome Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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15. |||||..... 45%  Qian M, Meng Y, Zhai L, Zheng R, Zhang L: [Study of endocardiac and extracardiac haemodynamics changes in fetus with increased nuchal translucency thickness]. Zhonghua Yi Xue Za Zhi; 2012 Jan 3;92(1):28-31
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  • [Title] [Study of endocardiac and extracardiac haemodynamics changes in fetus with increased nuchal translucency thickness].
  • OBJECTIVE: To explore the characteristics of endocardiac and extracardiac haemodynamics parameters in fetus with thickened nuchal translucency (NT) and analyze the relationship between hemodynamic changes and fetal prognosis.
  • The parameters were compared between fetus with thickened NT and normal fetus.
  • Four cases terminated pregnancy during the first or second trimester: one was diagnosed as persistent arterial trunk during a 13-week gestation, one with congenital cystic adenomatoid malformation during second trimester.
  • If abnormal endocardiac and extracardiac parameters are found in fetus with thickened NT, the existence of heart malformation should be considered.
  • When abnormal extracardiac Doppler waveshape or greater blood flow resistance is found with normal endocardiac parameters, prognostic follow-ups should be conducted with chromosomal examinations.
  • [MeSH-minor] Female. Heart Defects, Congenital / physiopathology. Heart Defects, Congenital / ultrasonography. Hemodynamics. Humans. Pregnancy. Pregnancy Trimester, First. Ultrasonography, Prenatal

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
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  • (PMID = 22490654.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
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16. |||||..... 45%  Kahloul N, Adouani M, Khattat N, Allani H, Krichen I, Zakhama A, Amri F: [Fetus in fetu: a case report]. Arch Pediatr; 2010 Mar;17(3):249-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Fetus in fetu: a case report].
  • [Transliterated title] Foetus in foetu : à propos d'un cas.
  • Fetus in fetu is an abnormality secondary to abnormal embryogenesis in a diamniotic, monochorionic pregnancy.
  • [MeSH-major] Fetus / abnormalities
  • [MeSH-minor] Abdomen / pathology. Abdomen / surgery. Calcinosis / diagnosis. Calcinosis / pathology. Diagnosis, Differential. Female. Humans. Infant, Newborn. Pregnancy. Tomography, X-Ray Computed. Ultrasonography

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  • [Copyright] Copyright 2009 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20116220.001).
  • [ISSN] 1769-664X
  • [Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
  • [ISO-abbreviation] Arch Pediatr
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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17. ||||...... 45%  Donders G, Bellen G, Rezeberga D: Aerobic vaginitis in pregnancy. BJOG; 2011 Sep;118(10):1163-70
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  • [Title] Aerobic vaginitis in pregnancy.
  • AV is characterised by an abnormal vaginal microflora accompanied by an increased localised inflammatory reaction and immune response, as opposed to the suppressed immune response that is characteristic of BV.
  • Given the increased local production of interleukin (IL)-1, IL-6 and IL-8 associated with AV during pregnancy, not surprisingly AV is associated with an increased risk of preterm delivery, chorioamnionitis and funisitis of the fetus.
  • The exact role of AV in pregnancy, the potential benefit of screening, and the use of newer local antibiotics, disinfectants, probiotics and immune modulators need further study.
  • [MeSH-major] Bacteria, Aerobic. Pregnancy Complications, Infectious. Vaginosis, Bacterial
  • [MeSH-minor] Female. Humans. Pregnancy


18. ||||...... 45%  Perles Z, Nir A, Gavri S, Golender J, Rein AJ: Intracardiac echogenic foci have no hemodynamic significance in the fetus. Pediatr Cardiol; 2010 Jan;31(1):7-10
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  • [Title] Intracardiac echogenic foci have no hemodynamic significance in the fetus.
  • It also is unknown whether ECFs predict abnormal cardiac performance.
  • The findings suggest that left-sided ECFs do not predict depressed left- or right-side systolic or diastolic properties in the fetus.
  • [MeSH-minor] Female. Gestational Age. Humans. Pregnancy. Prospective Studies

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  • (PMID = 19727924.001).
  • [ISSN] 1432-1971
  • [Journal-full-title] Pediatric cardiology
  • [ISO-abbreviation] Pediatr Cardiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. ||||...... 44%  du Plessis AJ: Cerebral blood flow and metabolism in the developing fetus. Clin Perinatol; 2009 Sep;36(3):531-48
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cerebral blood flow and metabolism in the developing fetus.
  • The inaccessibility of the human fetal brain to studies of perfusion and metabolism has impeded progress in the understanding of the normal and abnormal systems of oxygen substrate supply and demand.
  • Consequently, current understanding is based on studies in fetal animals or in the premature infant (ex utero fetus), neither of which is ideal.
  • Despite promising developments in fetal magnetic resonance imaging (MRI) and Doppler ultrasound, major advances in fetal neurodiagnostics will be required before rational and truly informed brainoriented care of the fetus becomes feasible.
  • [MeSH-major] Brain / blood supply. Brain / embryology. Brain / metabolism. Cerebrovascular Circulation / physiology. Fetus / blood supply. Fetus / metabolism. Hypoxia-Ischemia, Brain / metabolism. Pregnancy / metabolism

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  • (PMID = 19732612.001).
  • [ISSN] 1557-9840
  • [Journal-full-title] Clinics in perinatology
  • [ISO-abbreviation] Clin Perinatol
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / K24NS057568; United States / NICHD NIH HHS / HD / R21HD056009
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 129
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20. ||||...... 44%  Lopez P, Gonzalez D, Medina M, Plasencia W, Barber MA: First trimester abnormal profile and facial angle. Early features of anterior cephalocele. J Matern Fetal Neonatal Med; 2010 Oct;23(10):1260-2
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  • [Title] First trimester abnormal profile and facial angle. Early features of anterior cephalocele.
  • We present a first trimester scan suspicious of fetal anterior cephalocele due to the finding of a fetus with an abnormal profile and an abnormal facial angle, with a subsequent early confirmation at 16 weeks of gestation.
  • [MeSH-major] Encephalocele / ultrasonography. Face / abnormalities. Pregnancy Trimester, First. Ultrasonography, Prenatal
  • [MeSH-minor] Adult. Female. Humans. Image Interpretation, Computer-Assisted. Maxillofacial Abnormalities / ultrasonography. Pregnancy

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  • (PMID = 19968591.001).
  • [ISSN] 1476-4954
  • [Journal-full-title] The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • [ISO-abbreviation] J. Matern. Fetal. Neonatal. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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21. ||||...... 43%  Turchetti D, Pompilii E, Magrini E, Bonasoni MP, Pittalis MC, Segata M, Pession A, Santini D, Pilu G, Seri M: Persistence of a monosomic cell line in a fetus with mosaic trisomy 8. Am J Med Genet A; 2011 Nov;155A(11):2791-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Persistence of a monosomic cell line in a fetus with mosaic trisomy 8.
  • We report on a fetus presenting with an increased nuchal translucency, in which chorionic villus sampling led to the diagnosis of mosaic trisomy 8.
  • Pregnancy was terminated at 16(+6); postmortem examination showed additional findings including hypospadias, bilateral renal dysplasia, and focal portal fibrosis of the liver.
  • In order to confirm the presence of trisomy 8, FISH analysis was performed in abnormal renal and hepatic tissue, which, unexpectedly, showed a higher fraction of cells with only one fluorescent probe signal (43% and 23%, respectively), if compared with normal fetal liver and kidney (3-10%).
  • This finding is consistent with the survival in this fetus of a monosomic cell line after mitotic non-disjunction, which is in contrast with what is generally thought about mosaic trisomy genesis.
  • [MeSH-minor] Abnormal Karyotype. Abortion, Induced. Adult. Autopsy. Chorionic Villi Sampling. Chromosomes, Human, Pair 8 / genetics. Cleft Palate / pathology. Cleft Palate / ultrasonography. Female. Fetus / pathology. Humans. Hypospadias / diagnosis. Hypospadias / genetics. Hypospadias / pathology. In Situ Hybridization, Fluorescence. Kidney / pathology. Liver / pathology. Male. Nuchal Translucency Measurement. Pregnancy

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  • [Copyright] Copyright © 2011 Wiley Periodicals, Inc.
  • (PMID = 21932320.001).
  • [ISSN] 1552-4833
  • [Journal-full-title] American journal of medical genetics. Part A
  • [ISO-abbreviation] Am. J. Med. Genet. A
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] Chromosome 8, trisomy
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22. ||||...... 43%  Paolucci M, Palombi C, Sylla L, Stradaioli G, Monaci M: Ultrasonographic features of the mule embryo, fetus and fetal-placental unit. Theriogenology; 2012 Jan 15;77(2):240-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonographic features of the mule embryo, fetus and fetal-placental unit.
  • Mule EV first detection was observed earlier (37% at Day 8) than that observed in the equine pregnancy.
  • EV growth rate was 4.04 mm/day from Days 11 to 16, 0.4 mm/day from Days 16 to 28 and 1.78 mm/day from Days 28 to 45 of pregnancy.
  • An abnormal fetal-placental unit and fetal inactivity was observed in association with abortion.
  • Mule-conceptus biometric measurements correlated significantly with the gestational age, and these data were used to predict an unusually large mule fetus, which might result in dystocia.
  • In conclusion, we can assume that early diagnosis of pregnancy failure and assessment of fetal biophysical profile and growth charts could improve the chances of gestation completion in mule-pregnant mares.
  • The early detection of mares at risk for an abnormal pregnancy or delivery may increase the success of prompt treatments, therefore preventing costly emergency procedures and allowing proper obstetrical and neonatal assistance.
  • [MeSH-minor] Aging. Animals. Breeding. Female. Fetal Development. Fetus. Gestational Age. Parturition. Pregnancy

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 21958639.001).
  • [ISSN] 1879-3231
  • [Journal-full-title] Theriogenology
  • [ISO-abbreviation] Theriogenology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. ||||...... 43%  Hata T, Hanaoka U, Tenkumo C, Sato M, Tanaka H, Ishimura M: Three- and four-dimensional HDlive rendering images of normal and abnormal fetuses: pictorial essay. Arch Gynecol Obstet; 2012 Dec;286(6):1431-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three- and four-dimensional HDlive rendering images of normal and abnormal fetuses: pictorial essay.
  • METHODS: A total of 18 normal embryos and fetuses and 21 abnormal fetuses (one case each of thoracic meningocele, thickened nuchal translucency, multicystic dysplastic kidney, gastroschisis, omphalocele, and ovarian cyst, five of hydrops fetalis, three of skeletal abnormality, three of chromosome abnormality, two of cystic hygroma, and two of amniotic band syndrome) at 7-36 weeks' gestation were studied using the 3D/4D HDlive rendering mode.
  • RESULTS: In normal fetuses, marked embryonic development with advancing gestation was clearly shown in the first trimester of pregnancy, and various realistic facial expressions were noted in the second and third trimesters.
  • In abnormal fetuses, anatomically realistic features such as gross specimens were obtained.
  • [MeSH-major] Congenital Abnormalities / ultrasonography. Fetus / abnormalities. Fetus / anatomy & histology. Image Enhancement. Imaging, Three-Dimensional. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Amniotic Band Syndrome / ultrasonography. Bone and Bones / abnormalities. Bone and Bones / ultrasonography. Face / abnormalities. Face / ultrasonography. Facial Expression. Female. Fetal Development. Humans. Infant, Newborn. Male. Pregnancy. Pregnancy Trimester, First. Pregnancy Trimester, Second. Pregnancy Trimester, Third

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  • (PMID = 22868950.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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24. ||||...... 43%  Stanojevic M, Kurjak A, Salihagić-Kadić A, Vasilj O, Miskovic B, Shaddad AN, Ahmed B, Tomasović S: Neurobehavioral continuity from fetus to neonate. J Perinat Med; 2011 Mar;39(2):171-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurobehavioral continuity from fetus to neonate.
  • It is still uncertain whether a new scoring system for prenatal neurological assessment will be adequate for the distinction between normal and abnormal fetuses in low-risk pregnancies.
  • [MeSH-minor] Brain / anatomy & histology. Brain / embryology. Brain / growth & development. Child Development / physiology. Female. Fetal Development / physiology. Fetal Growth Retardation / physiopathology. Fetal Movement / physiology. Gravitation. Humans. Infant Behavior / physiology. Infant, Newborn. Infant, Premature. Infant, Small for Gestational Age. Pregnancy. Prenatal Nutritional Physiological Phenomena / physiology. Stress, Physiological. Ultrasonography, Prenatal

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  • (PMID = 21309634.001).
  • [ISSN] 1619-3997
  • [Journal-full-title] Journal of perinatal medicine
  • [ISO-abbreviation] J Perinat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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25. ||||...... 43%  Pederiva F, Lopez RA, Martinez L, Tovar JA: Tracheal innervation is abnormal in rats with experimental congenital diaphragmatic hernia. J Pediatr Surg; 2009 Jun;44(6):1159-64
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  • [Title] Tracheal innervation is abnormal in rats with experimental congenital diaphragmatic hernia.
  • Lung hypoplasia and lung sequelae accompany congenital diaphragmatic hernia (CDH) in which the vagus nerves and esophageal innervation are abnormal.
  • As the vagus supplies tracheal innervation, this study tested the hypothesis that it might also be abnormal in rats with CDH.
  • [MeSH-minor] Animals. Female. Fetus. Pregnancy. Rats. Rats, Sprague-Dawley

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  • (PMID = 19524733.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. ||||...... 43%  Josselin-Mahr L, Carbonne B, Cabane J: [Systemic sclerosis and pregnancy]. Rev Med Interne; 2011 Jun;32(6):363-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Systemic sclerosis and pregnancy].
  • Pregnancy in women diagnosed with systemic sclerosis is an infrequent situation with a generally favourable outcome according to the most recent studies.
  • Severe organ impairment, early diffuse systemic sclerosis and pulmonary hypertension ought to discourage patients from pregnancy, as these situations are at high risk of complications for both mother and fetus during pregnancy and puerperium.
  • During pregnancy, the most frequent maternal complication is worsening of gastroesophageal reflux, and the most severe complications are renal crisis and flaring arterial pulmonary hypertension.
  • Angiotensin converting enzyme inhibitors are indicated at any stage of the pregnancy if renal crisis is suspected.
  • During the pregnancy, abnormal bilateral uterine artery Doppler is a predictor of vascular insufficiency and might guide initiation of further preventive treatments.
  • Multicentric prospective cohort studies are warranted to identify more precisely the predictors of pregnancy-related complications and to define the best management of these patients.
  • [MeSH-major] Pregnancy Complications. Scleroderma, Systemic
  • [MeSH-minor] Female. Humans. Placenta / physiopathology. Pregnancy

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  • [Copyright] Copyright © 2010 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20633963.001).
  • [ISSN] 1768-3122
  • [Journal-full-title] La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne
  • [ISO-abbreviation] Rev Med Interne
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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27. ||||...... 43%  Ko YG, Hwang S, Kim SW, Kim H, Seong HH, Kim JH, Song Y, Yang BS, Song YM, Cho JH: Proteomic analysis of the extraembryonic tissues from cloned porcine fetus at day 35 of pregnancy. BMC Res Notes; 2014;7:861
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  • [Title] Proteomic analysis of the extraembryonic tissues from cloned porcine fetus at day 35 of pregnancy.
  • RESULTS: In the present study, we investigated differentially expressed proteins of the extraembryonic tissue from pig SCNT fetus compared to control (normal) fetus.
  • We obtained the extraembryonic tissue from embryos at day 35 of pregnancy and examined the protein expression profiles using two-dimensional electrophoresis (2-D) and Western blotting.
  • The extraembryonic tissue of fetus in control pregnancy was compared to the extraembryonic tissue of SCNT fetus, which showed an abnormally small size and shape as well as exhibited abnormal placental morphology compared to control fetus.
  • A proteomic analysis showed that the expression of 33 proteins was significantly increased or decreased in the extraembryonic tissue of SCNT fetus compared to control fetus.
  • The differentially expressed proteins in the extraembryonic tissue of SCNT fetus included ATP or lipid binding proteins, antioxidant proteins, translation elongation factors, and transcription factors.
  • Western blotting analysis indicated that antioxidant enzymes and anti-apoptotic proteins were down-regulated; however, the expression levels of apoptotic proteins, Bax and Hsp27, were increased in the extraembryonic tissue of SCNT fetus.
  • Moreover, immunohistochemical analysis also showed that the expression of the catalase or GPX genes was decreased in the extraembryonic tissue with SCNT fetus compared to those with control fetus.
  • In addition, we observed a significant decrease in DNA methytransferase1 (Dnmt1) expression in SCNT extraembryonic tissue, and the expression levels of Dnmt3a and Dnmt3b were abnormally higher in SCNT fetus compared to control fetus.
  • Moreover, a marked increase in the frequency of TUNEL-positive cells was observed in the extraembryonic tissue in SCNT fetus.
  • CONCLUSION: These results demonstrated that pig SCNT fetus showed abnormal protein expression in the extraembryonic tissue, and extensive apoptosis occurred in the extraembryonic tissue of the SCNT fetus due to an increase in apoptotic protein expression or a decrease in antioxidant protein expression.

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  • (PMID = 25433481.001).
  • [ISSN] 1756-0500
  • [Journal-full-title] BMC research notes
  • [ISO-abbreviation] BMC Res Notes
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. ||||...... 43%  Stukan M, Kruszewski Wiesław J, Dudziak M, Kopiejć A, Preis K: [Intestinal obstruction during pregnancy]. Ginekol Pol; 2013 Feb;84(2):137-41
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  • [Title] [Intestinal obstruction during pregnancy].
  • The incidence of intestinal obstruction during pregnancy is estimated at 1:1500-1:66431 pregnancies and is diagnosed in II and III trimester in most cases.
  • Symptoms of intestinal obstruction in pregnancy include: abdominal pains (98%), vomiting (82%), constipation (30%).
  • Abdominal tenderness on palpation is found in 71% and abnormal peristalsis in 55% of cases.
  • However ionizing radiation may have a harmful effect on the fetus, especially during the first trimester.
  • Ultrasonography and magnetic resonance imaging are considered safe and applicable during pregnancy.
  • Adhesive obstruction occurs more frequently in advanced pregnancy (6% - I trimester 28% - II trimester; 45% - III trimester 21% - puerperium).
  • Intestinal torsion during pregnancy mostly occurs in the sigmoid colon and cecum.
  • The risk of intestinal torsion is higher in the 16-20 and 32-36 weeks of pregnancy and during puerperium.
  • The authors point out the need for multi-specialty cooperation in the diagnostic-therapeutic process of pregnant women suspected with intestinal obstruction, since any delay in making a correct diagnosis increases the risk of severe complications, both for the woman and the fetus.
  • [MeSH-major] Intestinal Obstruction / diagnosis. Intestinal Obstruction / prevention & control. Maternal Welfare / statistics & numerical data. Pregnancy Complications / diagnosis. Pregnancy Complications / prevention & control
  • [MeSH-minor] Abdominal Pain / etiology. Adult. Evidence-Based Medicine. Female. Health Status. Humans. Nausea / etiology. Pregnancy. Pregnancy Outcome / epidemiology. Pregnancy Trimesters. Premature Birth. Risk Factors. Severity of Illness Index. Vomiting / etiology. Women's Health. Young Adult


29. ||||...... 43%  Pinar H, Carpenter M, Martin BJ, Tantravahi U: Utility of fetal karyotype in the evaluation of phenotypically abnormal stillbirths. Pediatr Dev Pathol; 2009 May-Jun;12(3):217-21
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  • [Title] Utility of fetal karyotype in the evaluation of phenotypically abnormal stillbirths.
  • Conventional karyotype analysis was successfully performed on 346 fetal tissue samples, 114 in anatomically normal and 232 in anatomically abnormal fetuses.
  • At the 450 to 500-band resolution level, 60 of the remaining 346 karyotypes were abnormal.
  • The 95% probability estimates of karyotype abnormality in the phenotypically abnormal and normal stillbirths, 5.5% and 5.6%, respectively, do not differ.
  • [MeSH-major] Chromosome Aberrations. Fetal Diseases / diagnosis. Fetus / abnormalities. Karyotyping / methods. Stillbirth / genetics
  • [MeSH-minor] Adult. Aneuploidy. Chromosome Banding. Female. Gestational Age. Humans. Infant, Newborn. Phenotype. Pregnancy. Young Adult

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  • (PMID = 19021454.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. ||||...... 42%  Zhong SL, Fang Q, Chen BJ, Han ZY, Luo YM, Chen JS, Xie YJ: [Clinical features of abnormal chromosome karyotypes in twin pregnancies complicated with structural abnormalities]. Zhonghua Fu Chan Ke Za Zhi; 2011 Sep;46(9):649-54
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  • [Title] [Clinical features of abnormal chromosome karyotypes in twin pregnancies complicated with structural abnormalities].
  • OBJECTIVE: To investigate the clinical features of the abnormal chromosome karyotypes in twin pregnancies complicated with fetal malformations.
  • They were divided into different groups according to (1) maternal age: the cases with maternal age ≥ 35 were divided into advanced pregnancy group (105 fetuses), and those with maternal age < 35 were divided into young pregnancy group (203 fetuses);.
  • (4) structural abnormalities: 205 fetuses with structural abnormalities were divided into the abnormal fetal group, and 103 fetuses without structural abnormalities were divided into the normal fetal group.
  • Twenty-six of 308 fetuses were found with abnormal chromosomes (8.4%, 26/308), and the aneuploid was the most common type of abnormal karyotypes (53.8%, 14/26).
  • Twenty-one of 205 fetuses with malformations were found with abnormal karyotypes (10.2%, 21/205). (2) Seven of 123 fetuses in MCT group were with abnormal karyotypes (5.7%, 7/123), and 19 of 185 fetuses in DCT group were with abnormal karyotypes (10.3%, 19/185).
  • There was no statistical difference of abnormal chromosome incidence between the two groups.
  • There were 14 fetuses with aneuploid in DCT group (7.6%, 14/185); but there was no fetus with aneuploid in MCT group.
  • In two cases of DCT group, only one fetus with malformation received chromosome examination because another fetus was dead, and the karyotypes were trisomy 21 and trisomy 18 respectively.
  • Both fetuses of the rest 17 cases received chromosome examination, and the chromosomes of both fetuses in each pregnancy were different.
  • Fifteen of 19 fetuses with abnormal chromosomes in DCT group were complicated with structural abnormalities, and 7 fetuses of 4 twin pregnancies in MCT group were with chromosomal abnormalities. (3) The comparison of the abnormal karyotype incidence between the advanced pregnancy group and young pregnancy group: the abnormal karyotype incidence of the advanced pregnancy group was 7.6% (8/105), and that was 8.9% (18/203) in young pregnancy group.
  • Six of 105 fetuses in advanced pregnancy group were aneuploids (5.7%, 6/105), and 8 of 203 fetuses in young pregnancy group were aneuploids (3.9%, 8/203).
  • The aneuploid incidence in advanced pregnancy group was significantly higher than that in young pregnancy group (P < 0.05).(4) The comparison of the abnormal karyotype incidence between the assisted reproductive group and the natural conception group: 11 of 81 fetuses were with the abnormal karyotypes in assisted reproductive group (13.6%, 11/81), and 15 of 227 fetuses were with the abnormal karyotypes in assisted reproductive group (6.6%, 15/227).
  • There were 7 fetuses with the aneuploid in assisted reproductive group (8.6%, 7/81) and 7 fetuses with the aneuploid in natural conception group (3.1%, 7/227), which showed no statistical difference (P > 0.05). (5) The comparison of the abnormal karyotype incidence between the abnormal fetal group and normal fetal group: 21 of 205 fetuses in abnormal fetal group were with abnormal karyotypes (10.2%, 21/205), and 5 of 103 fetuses in normal fetal group were with abnormal karyotypes (4.9%, 5/103).
  • 13 fetuses in abnormal fetal group were with the aneuploid (6.3%, 13/205), and only one fetus in normal fetal group was aneuploid (1.0%, 1/103).
  • CONCLUSIONS: Aneuploid is the most common abnormal karyotype in twin pregnancy complicated with fetal abnormalities, especially trisomy 21.
  • Aneuploid mainly occurs in only one fetus of DCT, and chromosomal discordance is usually found in DCT.
  • While in MCT, the twin fetuses with the same abnormal karyotype may have different phenotypes.
  • The results suggest that it is necessary to analyze both karyotypes of twins even if only one fetus is complicated with structural abnormalities.
  • [MeSH-major] Chromosome Aberrations. Congenital Abnormalities / ultrasonography. Diseases in Twins / ultrasonography. Pregnancy, Twin. Ultrasonography, Prenatal
  • [MeSH-minor] Adult. Aneuploidy. Cytogenetics. Female. Fetal Diseases / genetics. Fetal Diseases / ultrasonography. Humans. Karyotyping. Pregnancy. Pregnancy Outcome. Pregnancy Trimester, Second. Retrospective Studies. Young Adult

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  • (PMID = 22176987.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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31. ||||...... 42%  Guo YB, Ai Y, Zhao Y, Tang J, Jiang WY, Du ML, Ma HM, Zhong YF: [Rapid prenatal genetic diagnosis of a fetus with a high risk for Morquio A syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2012 Apr;29(2):126-30
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  • [Title] [Rapid prenatal genetic diagnosis of a fetus with a high risk for Morquio A syndrome].
  • OBJECTIVE: To provide rapid and accurate prenatal genetic diagnosis for a fetus with high risk of Morquio A syndrome.
  • RESULTS: DHPLC screening has identified abnormal double peaks in the PCR products of exons 1 and 10, whilst only a single peak was detected in normal controls.
  • Amplification of ARMS specific primers derived a specific product for the fetus's gene, whilst no similar product was detected in normal controls.
  • Sequencing of PCR products confirmed that exons 1 and 10 of the GALNS gene from the fetus contained a heterozygous paternal c.106-111 del (p.L36-L37 del) deletion and a heterozygous maternal c.1097 T>C (p.L366P) missense mutation, which resulted in a compound heterozygote status.
  • CONCLUSION: The fetus was diagnosed with Morquio A syndrome and a genotype similar to the proband.
  • Termination of the pregnancy was recommended.
  • Combined ARMS, DHPLC and DNA sequencing are effective for rapid and accurate prenatal diagnosis for fetus with a high risk for Morquio A syndrome.
  • [MeSH-minor] Base Sequence. Chondroitinsulfatases / genetics. Female. Humans. Molecular Sequence Data. Pedigree. Pregnancy. Pregnancy Complications / genetics. Risk Factors

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  • (PMID = 22487817.001).
  • [ISSN] 1003-9406
  • [Journal-full-title] Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
  • [ISO-abbreviation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.1.6.- / Chondroitinsulfatases; EC 3.1.6.4 / GALNS protein, human
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32. ||||...... 42%  Pugh SK, Poole AT, Hill JB, Magann EF, Chauhan SP, Morrison JC: Abnormal 1 hour glucose challenge test followed by a normal 3 hour glucose tolerance test: does it identify adverse pregnancy outcome? J Miss State Med Assoc; 2010 Jan;51(1):3-6
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  • [Title] Abnormal 1 hour glucose challenge test followed by a normal 3 hour glucose tolerance test: does it identify adverse pregnancy outcome?
  • OBJECTIVE: To determine if pregnancies with an abnormal glucose challenge test (GCT) but a normal (GTT) are at increased risk for fetal macrosomia or an adverse pregnancy outcome.
  • STUDY DESIGN: This prospective observational study matched women with an abnormal glucose challenge test and a normal GTT with the next patient with a normal GCT.
  • RESULTS: Over 12 months, 107 women with abnormal GCT were matched with 107 women with normal GCT.
  • Women with an abnormal GCT were older (27.3 vs. 24.7, p = 0.001) and less likely to be African-American (OR = 2.2, 95% CI 1.06-4.49) but no more likely to have an adverse pregnancy outcome.
  • CONCLUSION: Women with an abnormal GCT but a normal GTT are more likely to be older, less likely to be African-American, but no more likely to have an adverse pregnancy outcome or a macrosomic fetus.
  • [MeSH-major] Fetal Macrosomia. Glucose Tolerance Test. Obstetric Labor Complications. Pregnancy in Diabetics
  • [MeSH-minor] Adult. African Americans. Apgar Score. Cervical Ripening. Data Interpretation, Statistical. Female. Humans. Infant, Newborn. Labor, Obstetric. Pregnancy. Pregnancy Outcome. Prospective Studies. ROC Curve. Risk Factors. Time Factors


33. ||||...... 42%  Gedikbasi A, Akyol A, Yildirim G, Ekiz A, Gul A, Ceylan Y: Twin pregnancies complicated by a single malformed fetus: chorionicity, outcome and management. Twin Res Hum Genet; 2010 Oct;13(5):501-7
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  • [Title] Twin pregnancies complicated by a single malformed fetus: chorionicity, outcome and management.
  • The objective of this study was to evaluate the impact of one abnormal fetus in a twin pregnancy, to compare impact of chorionicity and clinical outcome of intervention and expectant management.
  • Thirty-seven dichorionic (DC) twins and 18 monochorionic (MC) twins complicated with one malformed fetus were evaluated for gestational age, birthweight and perinatal outcome.
  • The control groups consisted of 429 DC and 86 MC twins without anomalous fetus.
  • Because of limited data, the preliminary evaluation for expectant management and intervention, and survival of at least one normal fetus showed no impact.
  • [MeSH-major] Congenital Abnormalities / genetics. Diseases in Twins / congenital. Diseases in Twins / genetics. Pregnancy, Multiple / genetics
  • [MeSH-minor] Case-Control Studies. Chorion / pathology. Female. Humans. Infant, Newborn. Male. Pregnancy. Pregnancy Outcome. Premature Birth / etiology. Risk Factors. Twins, Dizygotic. Twins, Monozygotic

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  • (PMID = 20874474.001).
  • [ISSN] 1832-4274
  • [Journal-full-title] Twin research and human genetics : the official journal of the International Society for Twin Studies
  • [ISO-abbreviation] Twin Res Hum Genet
  • [Language] eng
  • [Publication-type] Journal Article; Twin Study
  • [Publication-country] Australia
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34. ||||...... 42%  Sliwa J, Respondek-Liberska M, Maroszyńska I, Krasomski G: [Ebstein's malformation in the fetus with cardiomegaly. To treat or to observe?--a case report]. Ginekol Pol; 2010 Feb;81(2):135-9
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  • [Title] [Ebstein's malformation in the fetus with cardiomegaly. To treat or to observe?--a case report].
  • Ebstein's malformation is a rare congenital cardiac defect characterized by an abnormal formation and/or displacement of the leaflets of the tricuspid valve.
  • This paper presents a case of a fetus with Ebstein's malformation with massive cardiomegaly (HA/CA = 0.62) in a 27-year-old patient in her first pregnancy.
  • The cardiac defect was diagnosed in the 22nd week of pregnancy.
  • Due to the fact that the patient decided to continue her pregnancy, and taking into consideration single reports of transplacental Digoxin therapy an attempt to apply Digoxin therapy was made.
  • The mother and the fetus were monitored in two centers, in Rzeszów and in Łódź.
  • [MeSH-minor] Cardiotonic Agents / administration & dosage. Echocardiography, Doppler. Fatal Outcome. Female. Humans. Infant, Newborn. Lung / abnormalities. Pregnancy. Tricuspid Valve Insufficiency / ultrasonography. Ultrasonography, Prenatal / methods

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  • (PMID = 20232713.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Cardiotonic Agents
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35. ||||...... 42%  Yin LJ, Zhang Y, Lv PP, He WH, Wu YT, Liu AX, Ding GL, Dong MY, Qu F, Xu CM, Zhu XM, Huang HF: Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Med; 2012;10:26
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  • [Title] Insufficient maintenance DNA methylation is associated with abnormal embryonic development.
  • BACKGROUND: Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood.
  • Abnormal function of these DNMTs may have serious consequences for embryonic development.
  • CONCLUSIONS: Our results demonstrate that defects in DNA maintenance methylation in the embryo, not in the mother, are associated with abnormal embryonic implantation and development.
  • [MeSH-minor] Abortion, Spontaneous / etiology. Animals. Decidua / enzymology. Disease Models, Animal. Female. Fetus / enzymology. Humans. Mice. Mice, Inbred ICR. Pregnancy

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  • (PMID = 22413869.001).
  • [ISSN] 1741-7015
  • [Journal-full-title] BMC medicine
  • [ISO-abbreviation] BMC Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] EC 2.1.1.- / DNA Modification Methylases
  • [Other-IDs] NLM/ PMC3355050
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36. ||||...... 42%  Sinkovskaya E, Abuhamad A, Horton S, Chaoui R, Karl K: Fetal left brachiocephalic vein in normal and abnormal conditions. Ultrasound Obstet Gynecol; 2012 Nov;40(5):542-8
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  • [Title] Fetal left brachiocephalic vein in normal and abnormal conditions.
  • OBJECTIVES: To establish values of fetal left brachiocephalic vein (LBCV) dimensions during normal pregnancy and determine whether routine assessment of the LBCV may help in identifying fetuses with congenital abnormalities of this vessel.
  • RESULTS: Sonographic assessment of the fetal LBCV was consistently achieved in the second and third trimesters and in some fetuses in the first trimester of pregnancy.
  • In normal fetuses LBCV diameter increased significantly throughout pregnancy, with a mean value of 0.7 mm at 11 weeks and 4.9 mm at term.
  • Abnormal course of the LBCV was noted in 12 fetuses.
  • CONCLUSION: This is the first study describing an effective sonographic approach for the assessment of fetal LBCV dimensions during pregnancy.
  • The normative data may provide an additional means of detecting rare anomalies of systemic and pulmonary veins during pregnancy.
  • [MeSH-major] Brachiocephalic Veins / abnormalities. Brachiocephalic Veins / ultrasonography. Fetus / abnormalities. Ultrasonography, Prenatal / methods
  • [MeSH-minor] Adult. Analysis of Variance. Arteriovenous Malformations / ultrasonography. Female. Humans. Imaging, Three-Dimensional. Pregnancy. Prospective Studies. Reproducibility of Results. Retrospective Studies. Statistics, Nonparametric. Ultrasonography, Doppler, Color

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  • [Copyright] Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
  • (PMID = 22461379.001).
  • [ISSN] 1469-0705
  • [Journal-full-title] Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • [ISO-abbreviation] Ultrasound Obstet Gynecol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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37. ||||...... 42%  Planellas M, Martin N, Pons C, Font J, Cairo J: Mummified fetus in the thoracic cavity of a domestic short-haired cat. Top Companion Anim Med; 2012 Feb;27(1):36-7
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  • [Title] Mummified fetus in the thoracic cavity of a domestic short-haired cat.
  • This short communication describes the diagnosis, treatment, and clinical course of a domestic short-haired cat with diaphragmatic hernia in which the herniated structure in the thoracic cavity contained a mummified fetus.
  • Some months later, during an ovariohysterectomy, an abnormal localization of the uterus was observed, and at that time the case was referred to our center.
  • A thoracic radiograph showed an abnormal thoracic mass cranial to the heart.
  • The main suspicion was the presence of a thoracic hernia with the uterus herniated and containing a mummified fetus.
  • Although this clinical case is quite rare, a mummified fetus can be observed in thoracic hernias.
  • [MeSH-major] Cat Diseases / diagnosis. Cats / abnormalities. Fetus. Hernia, Diaphragmatic / veterinary. Thoracic Cavity / pathology
  • [MeSH-minor] Animals. Female. Fetal Death / veterinary. Pregnancy. Thoracotomy / veterinary

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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22958796.001).
  • [ISSN] 1938-9736
  • [Journal-full-title] Topics in companion animal medicine
  • [ISO-abbreviation] Top Companion Anim Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. ||||...... 42%  Guzel AI, Demirhan O, Pazarbasi A, Ozgunen FT, Kocaturk-Sel S, Tastemir D: Detection of parental origin and cell stage errors of a double nondisjunction in a fetus by QF-PCR. Genet Test Mol Biomarkers; 2009 Feb;13(1):73-7
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  • [Title] Detection of parental origin and cell stage errors of a double nondisjunction in a fetus by QF-PCR.
  • AIM: To investigate parental origins and cell stage errors of a double nondisjunction in a fetus.
  • METHOD: For the determination of the most common chromosome anomalies, quantitative fluorescent polymerase chain reaction method using short tandem repeat (STR) DNA markers was applied to a fetus with abnormal ultrasonographic findings.
  • RESULTS: A double nondisjunction including chromosomes 21 and X (48,XXX,+21) was detected prenatally in the fetus.
  • [MeSH-minor] Adult. Aneuploidy. Chromosomes, Human, Pair 21 / genetics. Chromosomes, Human, X / genetics. Down Syndrome / diagnosis. Down Syndrome / genetics. Female. Humans. Karyotyping. Male. Meiosis / genetics. Microsatellite Repeats. Pregnancy. Trisomy / diagnosis. Trisomy / genetics

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  • (PMID = 19309277.001).
  • [ISSN] 1945-0257
  • [Journal-full-title] Genetic testing and molecular biomarkers
  • [ISO-abbreviation] Genet Test Mol Biomarkers
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Unknown
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39. ||||...... 42%  Caron P: [Thyroid dysfunctions and pregnancy]. Presse Med; 2011 Dec;40(12 Pt 1):1174-81
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  • [Title] [Thyroid dysfunctions and pregnancy].
  • Advances in understanding the physiology of the thyroid function in normal pregnancy have highlighted the importance of the consequences of abnormal thyroid function on mother and fetal outcomes.
  • For each thyroid dysfunction (hypothyroxinemia, hypothyroidism, hyperthyroidism, postpartum thyroiditis), the issues with the obstetric complications of the mother and the fetus are considered.
  • Indeed, early recognition of thyroid diseases during pregnancy and appropriate management has the potential to improve outcome for the mother and the fetus.
  • [MeSH-major] Pregnancy Complications / etiology. Thyroid Diseases / complications
  • [MeSH-minor] Adult. Asymptomatic Diseases / epidemiology. Asymptomatic Diseases / therapy. Disease Progression. Female. Humans. Iodine / deficiency. Postpartum Thyroiditis / diagnosis. Postpartum Thyroiditis / epidemiology. Postpartum Thyroiditis / therapy. Pregnancy. Young Adult

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  • [Copyright] Copyright © 2011 Elsevier Masson SAS. All rights reserved.
  • (PMID = 22078088.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse médicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Chemical-registry-number] 9679TC07X4 / Iodine
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40. ||||...... 42%  Divanović A, Witte D, Michelfelder E: A fetus with hypoplastic left heart syndrome and tricuspid stenosis with evolving hydrops fetalis. Pediatr Cardiol; 2012 Oct;33(7):1210-2
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  • [Title] A fetus with hypoplastic left heart syndrome and tricuspid stenosis with evolving hydrops fetalis.
  • A rare case of HLHS involving a fetus with tricuspid valve stenosis, abnormal venous Doppler findings, and hydrops is reported.
  • [MeSH-minor] Autopsy. Echocardiography, Doppler. Fatal Outcome. Female. Humans. Infant, Newborn. Pregnancy


41. ||||...... 42%  Buyon JP: Updates on lupus and pregnancy. Bull NYU Hosp Jt Dis; 2009;67(3):271-5
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  • [Title] Updates on lupus and pregnancy.
  • This review focuses on events subsequent to planning a pregnancy and addresses three components of concern for women with systemic lupus erythematosus: maternal, placental, and fetal.
  • For patients who begin pregnancy with an abnormal creatinine (> 2 mg/dl is ill advised), risks include hypertension, preeclampsia, high rate of fetal loss, and possible further deterioration of renal function.
  • For patients with anti-phospholipid antibodies detected in the frst trimester of pregnancy, the lupus anticoagulant per se may be the strongest predictor of pregnancy complications.
  • [MeSH-major] Lupus Erythematosus, Systemic / immunology. Pregnancy Complications / immunology
  • [MeSH-minor] Antibodies, Antinuclear / blood. Cardiovascular Agents / adverse effects. Female. Fetus / immunology. Health Status Indicators. Heart Defects, Congenital / immunology. Humans. Kidney Diseases / immunology. Maternal-Fetal Exchange. Pregnancy. Pregnancy Outcome. Risk Assessment. Risk Factors. Severity of Illness Index. Steroids / adverse effects


42. ||||...... 42%  Rozovsky K, Sosna J, Le Merrer M, Simanovsky N, Koplewitz BZ, Bar-Ziv J, Cormier-Daire V, Raas-Rothschild A: Spondyloepimetaphyseal dysplasia, short limb-abnormal calcifications type: progressive radiological findings from fetal age to adolescence. Pediatr Radiol; 2011 Oct;41(10):1298-307
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  • [Title] Spondyloepimetaphyseal dysplasia, short limb-abnormal calcifications type: progressive radiological findings from fetal age to adolescence.
  • BACKGROUND: Spondyloepimetaphyseal dysplasia, short limb-abnormal calcifications type (SEMD, SL-AC) is a rare autosomal recessive condition with a grave prognosis.
  • MATERIALS AND METHODS: We retrospectively evaluated radiological findings on plain films, CT and MRI for eight children with genetically proven SEMD (male:female ratio 4:4, ages 30-week fetus to 18 years) and summarized findings from case reports and case series in the literature.
  • Disease progression was characterized by anterior dislocation of C1, kyphoscoliosis, bowing of the limbs, metaphyseal and epiphyseal changes and abnormal calcifications.
  • Earliest appearance of abnormal calcifications was 1.5 years; four children had no abnormal calcifications at diagnosis.
  • Absence of abnormal calcifications does not preclude the diagnosis.
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Magnetic Resonance Imaging. Male. Mutation. Pregnancy. Prenatal Diagnosis. Receptor Protein-Tyrosine Kinases / genetics. Receptors, Mitogen / genetics. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 21818555.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Mitogen; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / discoidin receptor
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43. ||||...... 42%  Espinoza J, Espinoza AF, Power GG: High fetal plasma adenosine concentration: a role for the fetus in preeclampsia? Am J Obstet Gynecol; 2011 Nov;205(5):485.e24-7
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  • [Title] High fetal plasma adenosine concentration: a role for the fetus in preeclampsia?
  • OBJECTIVE: Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear.
  • Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV).
  • Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 ± 0.15 μmol/L), but not with normal UADV (0.58 ± 0.14 μmol/L), were significantly higher than in normal pregnancies (P < .0001).
  • [MeSH-minor] Adult. Female. Humans. Pregnancy. Uterine Artery

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  • [Copyright] Copyright © 2011 Mosby, Inc. All rights reserved.
  • [CommentIn] Am J Obstet Gynecol. 2012 Apr;206(4):e5-6; author reply e6-7 [22281430.001]
  • (PMID = 21855848.001).
  • [ISSN] 1097-6868
  • [Journal-full-title] American journal of obstetrics and gynecology
  • [ISO-abbreviation] Am. J. Obstet. Gynecol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] K72T3FS567 / Adenosine
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44. ||||...... 42%  Cecati M, Giannubilo SR, Emanuelli M, Tranquilli AL, Saccucci F: HLA-G and pregnancy adverse outcomes. Med Hypotheses; 2011 Jun;76(6):782-4
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  • [Title] HLA-G and pregnancy adverse outcomes.
  • There is growing evidence that pregnancy complications such as preeclampsia, recurrent pregnancy loss (RPL), IUGR, and premature birth could be associated with abnormal immunologic interactions at the fetal-maternal interface.
  • HLA-G expression and HLA-G genetic variations in both the mother and the embryo/fetus may be important for pregnancy outcome.
  • It is also intuitively apparent that a gene with putative immunosuppressive and immunotolerant potential might be functional in both the mother and the embryo/fetus/placenta.
  • Reduced or aberrant HLA-G expression seems to be associated with certain complications of pregnancy, among which preeclampsia and possibly the risk of miscarriage, and that this may be further linked to HLA-G polymorphisms.
  • Most of the studies aimed at assessing the role of HLA-G in pregnant diseases have considered only the maternal genotype and ignored the contribution of the fetus.
  • In this regard, the mother, placenta and the fetus form a synthesis.
  • Therefore, studies on placental diseases should address HLA-G expression and genetic variations also to the fetus/placenta.
  • [MeSH-major] HLA Antigens / immunology. Histocompatibility Antigens Class I / immunology. Pregnancy Complications / immunology. Pregnancy Outcome
  • [MeSH-minor] Female. HLA-G Antigens. Humans. Pregnancy


45. ||||...... 41%  Kishimoto Y, Kanai T, Sato K, Lee J, Jeong KS, Shimokado K, Maruyama N, Ishigami A: Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice. Pediatr Res; 2013 May;73(5):578-84
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  • [Title] Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice.
  • BACKGROUND: Despite the acknowledged importance of ascorbic acid (AA) in maintaining pregnancy and normal fetal development, its precise actions remain obscure.
  • Morphological analysis revealed that the latter neonates of SMP30/GNL KO mothers whose intake of AA was low during gestation manifested abnormal cardiac dilation, congestion of the liver and lungs, incompletely expanded pulmonary alveoli, and impaired vertebral bodies.
  • CONCLUSION: A diet sufficiently replete with AA is essential during the gestational period for normal tissue development in the fetus and neonate.
  • [MeSH-major] Ascorbic Acid / administration & dosage. Calcium-Binding Proteins / genetics. Carboxylic Ester Hydrolases / genetics. Heart / physiopathology. Intracellular Signaling Peptides and Proteins / genetics. Pregnancy, Animal
  • [MeSH-minor] Animals. Animals, Newborn. Female. Mice. Mice, Knockout. Pregnancy. Tissue Distribution

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  • (PMID = 23385962.001).
  • [ISSN] 1530-0447
  • [Journal-full-title] Pediatric research
  • [ISO-abbreviation] Pediatr. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Intracellular Signaling Peptides and Proteins; 0 / Rgn protein, mouse; EC 3.1.1.- / Carboxylic Ester Hydrolases; EC 3.1.1.17 / gluconolactonase; PQ6CK8PD0R / Ascorbic Acid
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46. ||||...... 41%  Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ: Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology; 2011 Mar;114(3):521-8
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  • [Title] Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults.
  • BACKGROUND: Preclinical evidence suggests that commonly used anesthetic agents induce long-lasting neurobehavioral changes when administered early in life, but there has been virtually no attention to the neurodevelopmental consequences for the fetus of maternal anesthesia.
  • This study tested the hypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, which corresponds to the second trimester in humans, would be behaviorally abnormal as adults.
  • [MeSH-minor] Anesthesia. Animals. Anxiety / psychology. Blood Pressure / drug effects. Body Weight / physiology. Brain / pathology. Female. Male. Maze Learning / drug effects. Motor Activity / drug effects. Pregnancy. Psychomotor Performance / drug effects. Rats. Rats, Sprague-Dawley. Recognition (Psychology) / drug effects. gamma-Aminobutyric Acid / physiology

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  • (PMID = 21307768.001).
  • [ISSN] 1528-1175
  • [Journal-full-title] Anesthesiology
  • [ISO-abbreviation] Anesthesiology
  • [Language] eng
  • [Grant] United States / NIGMS NIH HHS / GM / K08 GM077057; United States / NIGMS NIH HHS / GM / K08 GM077057-04; United States / NINDS NIH HHS / NS / K08NS048140; United States / NIGMS NIH HHS / GM / KO8 GM077057; United States / NIA NIH HHS / AG / R01 AG020253; United States / NIA NIH HHS / AG / R01 AG020253-04; United States / NIA NIH HHS / AG / R01 AG20253; United States / NIGMS NIH HHS / GM / R01 GM088801; United States / NIGMS NIH HHS / GM / R01 GM088817; United States / NIGMS NIH HHS / GM / R01 GM088817; United States / NIA NIH HHS / AG / R21AG029856
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; 56-12-2 / gamma-Aminobutyric Acid; CYS9AKD70P / Isoflurane
  • [Other-IDs] NLM/ NIHMS265860; NLM/ PMC3071297
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47. ||||...... 41%  Vauloup-Fellous C, Bouthry E, Grangeot-Keros L: [Infections transmitted from the mother to the fetus: diagnostic issues and management of pregnancy]. Ann Biol Clin (Paris); 2013 Nov;71:5-18
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  • [Title] [Infections transmitted from the mother to the fetus: diagnostic issues and management of pregnancy].
  • Some infections are considered as feared risks during pregnancy.
  • These infections may lead to severe damage of the fetus or the newborn depending on the infectious agent and the term of pregnancy where the infection occurred.
  • However, biological diagnosis is also essential when maternal/neo-natal clinical symptoms or abnormal ultrasound findings are observed.
  • [MeSH-major] Infectious Disease Transmission, Vertical. Pregnancy Complications, Infectious / diagnosis. Pregnancy Complications, Infectious / therapy
  • [MeSH-minor] Chickenpox / diagnosis. Chickenpox / therapy. Chickenpox / transmission. Cytomegalovirus Infections / diagnosis. Cytomegalovirus Infections / therapy. Cytomegalovirus Infections / transmission. Female. Fetal Diseases / diagnosis. Fetal Diseases / therapy. Humans. Infant, Newborn. Parvoviridae Infections / diagnosis. Parvoviridae Infections / therapy. Parvoviridae Infections / transmission. Pregnancy. Rubella / diagnosis. Rubella / therapy. Rubella / transmission. Toxoplasmosis / diagnosis. Toxoplasmosis / therapy. Toxoplasmosis / transmission

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  • (PMID = 24235323.001).
  • [ISSN] 1950-6112
  • [Journal-full-title] Annales de biologie clinique
  • [ISO-abbreviation] Ann. Biol. Clin. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Keywords] NOTNLM ; biological diagnosis / management / materno-fetal infections / prevention
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48. ||||...... 41%  de Mooij YM, van den Akker NM, Bekker MN, Bartelings MM, Wisse LJ, van Vugt JM, Gittenberger-de Groot AC: Abnormal Shh and FOXC2 expression correlates with aberrant lymphatic development in human fetuses with increased nuchal translucency. Prenat Diagn; 2009 Sep;29(9):840-6
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  • [Title] Abnormal Shh and FOXC2 expression correlates with aberrant lymphatic development in human fetuses with increased nuchal translucency.
  • OBJECTIVE: Previous research in fetuses with increased nuchal translucency (NT) showed abnormal lymphatic endothelial differentiation characteristics, including increased vascular endothelial growth factor (VEGF)-A expression, and aberrant smooth muscle cells (SMCs) surrounding enlarged jugular lymphatic sacs (JLS).
  • We hypothesized that abnormal Sonic hedgehog (Shh) expression would result in altered VEGF-A signaling in the lymphatic endothelial cells of the JLS and that aberrant acquisition of SMCs could be caused by downregulation of forkhead transcription factor FOXC2 and upregulation of platelet-derived growth factor (PDGF)-B in the lymphatic endothelial cells of the JLS.
  • [MeSH-minor] Biological Markers / analysis. Blood Vessels / metabolism. Down Syndrome / diagnosis. Down Syndrome / metabolism. Endothelial Cells / metabolism. Female. Fetal Development / physiology. Fetal Heart / anatomy & histology. Fetus / abnormalities. Fetus / metabolism. Humans. Lymphatic Vessels / embryology. Lymphatic Vessels / metabolism. Neck / embryology. Pregnancy. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 19548265.001).
  • [ISSN] 1097-0223
  • [Journal-full-title] Prenatal diagnosis
  • [ISO-abbreviation] Prenat. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biological Markers; 0 / Forkhead Transcription Factors; 0 / Hedgehog Proteins; 0 / SHH protein, human; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / mesenchyme fork head 1 protein
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49. ||||...... 41%  Sir-Petermann T, Ladrón de Guevara A, Villarroel AC, Preisler J, Echiburú B, Recabarren S: [Polycystic ovary syndrome and pregnancy]. Rev Med Chil; 2012 Jul;140(7):919-25
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  • [Title] [Polycystic ovary syndrome and pregnancy].
  • Polycystic ovary syndrome (PCOS) is a common endocrine metabolic dysfunction closely associated with insulin resistance and obesity, which predisposes to pregnancy complications and prenatal programming of the offspring.
  • The aim of this review is to report our experience in PCOS patients who became pregnant and were followed during the whole pregnancy.
  • Firstly, we analyzed the effect of pregnancy on PCOS pathophysiology and secondly the role of PCOS in pregnancy outcomes.
  • Regarding the firstpoint, during normal pregnancy a progressive insulin resistance, serum lipid changes and an increase in androgen levels is observed, which is exacerbated in the PCOS condition.
  • Regarding the second point, PCOS is associated with an increased risk for maternal complications such as gestational diabetes (GDM) and pregnancy-induced hypertension.
  • Moreover, these adverse pregnancy outcomes are more frequently associated with an increase in low birth weight and high birth weight newborns.
  • According to our clinical experience, PCOS patients who became pregnant and were not treated with metformin during the whole pregnancy, showed a higher prevalence of gestational diabetes and SGA newborns, which was improved with metformin treatment.
  • In summary, pregnancy may constitute a period in which an abnormal condition is established or aggravated in the fetus of a PCOS mother.
  • [MeSH-major] Polycystic Ovary Syndrome / complications. Pregnancy Complications
  • [MeSH-minor] Animals. Birth Weight / physiology. Diabetes, Gestational / etiology. Female. Fetus / embryology. Humans. Male. Models, Animal. Pregnancy. Pregnancy Outcome


50. ||||...... 41%  Chen F, Du S, Bian J, You ZB, Wu Y: Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats. Horm Behav; 2012 Apr;61(4):504-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chronic hypoxia exposure during pregnancy is associated with a decreased active nursing activity in mother and an abnormal birth weight and postnatal growth in offspring of rats.
  • Stress during pregnancy is known to have a significant impact on animal's behavior and offspring development.
  • Altitude hypoxia (3 and 5 km) was simulated in the hypobaric chambers during the last week of pregnancy and the effects were compared to those found in controls exposed at sea level.
  • Hypoxia exposure was associated with abnormal birth weight and postnatal growth in pups, with a significantly higher and lower birth weight than control found in 3 and 5 km groups, respectively, and accelerated growth in both stressed groups.
  • Taken together, the present results indicate that hypoxia, particularly severe hypoxia during the late phase of pregnancy has a significantly adverse impact on animal's behavior, endocrine function and offspring development.
  • The higher birth weight found in the offspring of 3 km group suggests a compensatory system counteracting with the inhibitory effects of hypoxia on fetus growth at this altitude.
  • [MeSH-minor] Adrenal Cortex / physiology. Analysis of Variance. Animals. Body Weight / physiology. Chronic Disease. Corticosterone / blood. Female. Grooming. Nesting Behavior. Pregnancy. Rats. Rats, Sprague-Dawley. Survival Analysis

  • MedlinePlus Health Information. consumer health - Birth Weight.
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  • [Copyright] Copyright © 2012 Elsevier Inc. All rights reserved.
  • (PMID = 22285933.001).
  • [ISSN] 1095-6867
  • [Journal-full-title] Hormones and behavior
  • [ISO-abbreviation] Horm Behav
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] W980KJ009P / Corticosterone
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