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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 50%  Miyamura M, Schnell O, Yamashita C, Yoshioka T, Matsumoto C, Mori T, Ukimura A, Kitaura Y, Matsumura Y, Ishizaka N, Hayashi T: Effects of acarbose on the acceleration of postprandial hyperglycemia-induced pathological changes induced by intermittent hypoxia in lean mice. J Pharmacol Sci; 2010;114(1):32-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of acarbose on the acceleration of postprandial hyperglycemia-induced pathological changes induced by intermittent hypoxia in lean mice.
  • Postprandial hyperglycemia (PPH) and intermittent hypoxia related to the sleep apnea syndrome are important predictors of cardiovascular disease.
  • We investigated the effects of intermittent hypoxia on pathological changes in the left ventricular (LV) myocardium caused by PPH in lean mice and evaluated the influence of acarbose, an α-glucosidase inhibitor.
  • Male C57BL/6J mice aged 8 weeks were exposed to intermittent hypoxia (8 h/day during the daytime) or kept under normoxia.
  • Intermittent hypoxia exacerbated cardiomyocyte hypertrophy and interstitial fibrosis in the LV myocardium of RD mice.
  • Superoxide production and expression of 4-hydroxy-2-nonenal in the LV myocardium with intermittent hypoxia were increased in RD mice, but not AL mice.

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  • (PMID = 20703014.001).
  • [ISSN] 1347-8648
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] T58MSI464G / Acarbose
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2. ||||...... 44%  Feng J, Wu Q, Zhang D, Chen BY: Hippocampal impairments are associated with intermittent hypoxia of obstructive sleep apnea. Chin Med J (Engl); 2012 Feb;125(4):696-701
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hippocampal impairments are associated with intermittent hypoxia of obstructive sleep apnea.
  • Obstructive sleep apnea (OSA), which is the most common sleep-related breathing disorder, is characterized as frequent upper airway collapse and obstruction.
  • In studies of OSA, it is difficult to differentiate the effects of its two main pathologic traits, intermittent hypoxia (IH) and sleep fragmentation.
  • IH, continuous hypoxia and intermittent continuous hypoxia can all result in decreases in arterial O2.
  • [MeSH-major] Anoxia / physiopathology. Hippocampus / physiopathology. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 22490498.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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3. ||||...... 40%  Feng J, Chiang AA, Wu Q, Chen BY, Cui LY, Liang DC, Zhang ZL, Yao W: Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats. Chin Med J (Engl); 2010 Sep;123(17):2392-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats.
  • BACKGROUND: Sleep disturbance is common in patients with emphysema.
  • This study aimed to develop a novel model of sleep-related hypoxemia (SRH) in emphysema (SRHIE) with rats, and to explore the inflammatory status of SRHIE in lung, liver, pancreas, carotid artery and whole blood.
  • The protocols varied with the degree of hypoxia exposure and severity of pre-existing emphysema caused by cigarette smoke exposure:.
  • (1) SRH control (SRHCtrl) group, sham smoke exposure (smoke exposure, exposed to smoke of 15 cigarettes twice everyday, 16 weeks) and SRH exposure (12.5% O2, 3 hours, SRH exposure, divide total hypoxia time (1.5 hours or 3 hours) into 4 periods evenly (22.5 minutes or 45 minutes) and distribute these hypoxia periods evenly into physiological sleep time of rats identified by electroencephalogram, week 9 to week 16);.
  • [MeSH-major] Anoxia / complications. Emphysema / complications. Inflammation / etiology. Sleep / physiology

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  • (PMID = 21034555.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hemoglobins
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4. ||||...... 40%  Beuchée A, Hernández AI, Duvareille C, Daniel D, Samson N, Pladys P, Praud JP: Influence of hypoxia and hypercapnia on sleep state-dependent heart rate variability behavior in newborn lambs. Sleep; 2012 Nov;35(11):1541-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of hypoxia and hypercapnia on sleep state-dependent heart rate variability behavior in newborn lambs.
  • STUDY OBJECTIVES: Although hypercapnia and/or hypoxia are frequently present during chronic lung disease of infancy and have also been implicated in sudden infant death syndrome (SIDS), their effect on cardiac autonomic regulation remains unclear.
  • The authors' goal is to test that hypercapnia and hypoxia alter sleep-wake cycle-dependent heart rate variability (HRV) in the neonatal period.
  • DESIGN: Experimental study measuring HRV during sleep states in lambs randomly exposed to hypercapnia, hypoxia, or air.
  • INTERVENTIONS: Each lamb underwent polysomnographic recordings while in a chamber flowed with either air or 21% O(2) + 5% CO(2) (hypercapnia) or 10% O(2) + 0% CO(2) (hypoxia) on day 3, 4, and 5 of postnatal age.
  • MEASUREMENTS AND RESULTS: Hypercapnia increased the time spent in wakefulness and hypoxia the time spent in quiet sleep (QS).
  • Compared with QS, active sleep (AS) was associated with an overall increase in HRV magnitude and short-term self-similarity and a decrease in entropy of cardiac cycle length in air.
  • This AS-related HRV pattern persisted in hypercapnia and was even more pronounced in hypoxia.
  • CONCLUSION: Enhancement of AS-related sympathovagal coactivation in hypoxia, together with increased heart rate regularity, may be evidence that AS + hypoxia represent a particularly vulnerable state in early life.
  • This should be kept in mind when deciding the optimal arterial oxygenation target in newborns and when investigating the potential involvement of hypoxia in SIDS pathogenesis.
  • [MeSH-major] Anoxia / physiopathology. Heart Rate. Hypercapnia / physiopathology. Sleep

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  • (PMID = 23115403.001).
  • [ISSN] 1550-9109
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP 15558
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3466801
  • [Keywords] NOTNLM ; Entropy / REM sleep / frequency domain analysis / quiet sleep / scale-invariance / sympathovagal coactivation
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5. ||||...... 37%  Nakagawa Y, Kishida K, Kihara S, Yoshida R, Funahashi T, Shimomura I: Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. J Atheroscler Thromb; 2011;18(3):240-7
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  • [Title] Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue.
  • AIM: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with atherosclerotic cardio-vascular disease.
  • Venous blood samples were collected before sleep and after waking up.
  • We investigated the effect of hypoxia on adiponectin expression in mesenteric and subcutaneous fat tissues of obese yellow-KKAy mice.
  • In obese yellow-KKAy mice, exposure to hypoxia for 2 days suppressed plasma adiponectin levels, with no apparent change in mesenteric and subcutaneous fat tissue adiponectin mRNA expression.
  • CONCLUSIONS: These findings suggest that abdominal obesity, representing abundant mesenteric fat tissue susceptible to hypoxic stress, partly explains Δadiponectin in OSAS patients, and that reduction of visceral fat accumulation may combat OSAS-related atherosclerotic cardiovascular diseases in abdominal obesity.
  • [MeSH-major] Adiponectin / metabolism. Adipose Tissue / metabolism. Anoxia. Circadian Rhythm / physiology. Mesentery / metabolism. Sleep Apnea, Obstructive / metabolism

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  • (PMID = 21139317.001).
  • [ISSN] 1880-3873
  • [Journal-full-title] Journal of atherosclerosis and thrombosis
  • [ISO-abbreviation] J. Atheroscler. Thromb.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adiponectin
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6. ||||...... 37%  Türkay C, Ozol D, Kasapoğlu B, Kirbas I, Yıldırım Z, Yiğitoğlu R: Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia. Respir Care; 2012 Feb;57(2):244-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia.
  • BACKGROUND: Currently the common pathogenetic mechanisms in nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) are gaining increased attention.
  • The aim of this study is to find out the influence of chronic intermittent hypoxemia and OSA related parameters to the severity of NAFLD.
  • Our multivariate analysis showed that AHI, oxygen desaturation index, lowest desaturation values, and percentage of sleep duration with S(pO(2)) < 90% were independent predictors of NAFLD after adjustment for BMI, weight, and insulin resistance.
  • Furthermore, the most correlated parameter for the severity of NAFLD was found as the duration of hypoxia during sleep.
  • [MeSH-major] Anoxia. Fatty Liver. Oxygen / analysis. Sleep Apnea, Obstructive

  • HSDB. structure - OXYGEN.
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  • (PMID = 21762556.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen; Non-alcoholic Fatty Liver Disease
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7. ||||...... 37%  Giusi G, Zizza M, Facciolo RM, Chew SF, Ip YK, Canonaco M: Aestivation and hypoxia-related events share common silent neuron trafficking processes. BMC Neurosci; 2012;13:39
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  • [Title] Aestivation and hypoxia-related events share common silent neuron trafficking processes.
  • BACKGROUND: The availability of oxygen is a limiting factor for neuronal survival since low levels account not only for the impairment of physiological activities such as sleep-wake cycle, but above all for ischemic-like neurodegenerative disorders.
  • This functional relationship might have therapeutic bearings for hypoxia-related dysfunctions, above all in view of recently identified silent neuron-dependent motor activity ameliorations in mammals.
  • [MeSH-major] Anoxia. Estivation / physiology. Gene Expression Regulation / physiology. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neurons / metabolism

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  • (PMID = 22520032.001).
  • [ISSN] 1471-2202
  • [Journal-full-title] BMC neuroscience
  • [ISO-abbreviation] BMC Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HSP72 Heat-Shock Proteins; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; 0 / Receptors, AMPA; 0 / glutamate receptor ionotropic, AMPA 1; 0 / glutamate receptor ionotropic, AMPA 2
  • [Other-IDs] NLM/ PMC3407487
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8. |||||||||. 1053%  Kuhle S, Urschitz MS, Eitner S, Poets CF: Interventions for obstructive sleep apnea in children: a systematic review. Sleep Med Rev; 2009 Apr;13(2):123-31
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  • [Title] Interventions for obstructive sleep apnea in children: a systematic review.
  • BACKGROUND: Obstructive sleep apnea (OSA) is characterized by habitual snoring, heavy breathing, sleep-related hypoxia and arousals from sleep, and is found in approximately 3% of children.
  • [MeSH-major] Sleep Apnea, Obstructive / therapy

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  • (PMID = 19059794.001).
  • [ISSN] 1087-0792
  • [Journal-full-title] Sleep medicine reviews
  • [ISO-abbreviation] Sleep Med Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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9. |||||||||. 1022%  Shepard P, Lam EM, St Louis EK, Dominik J: Sleep disturbances in myotonic dystrophy type 2. Eur Neurol; 2012;68(6):377-80
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  • [Title] Sleep disturbances in myotonic dystrophy type 2.
  • Sleep disorders in myotonic dystrophy type 1 (DM1) are common and include sleep-disordered breathing, hypersomnia, and fatigue.
  • Little is known regarding the occurrence of sleep disturbance in myotonic dystrophy type 2 (DM2).
  • We hypothesized that DM2 patients may frequently harbor sleep disorders.
  • We reviewed medical records of all genetically confirmed cases of DM2 seen at our sleep center between 1997 and 2010 for demographic, laboratory, overnight oximetry, and polysomnography (PSG) data.
  • Obstructive sleep apnea was diagnosed in 3 of 5 patients (60%) studied with PSG.
  • The clinical spectrum of DM2 may include a wide range of sleep disturbances.
  • Although respiratory muscle weakness was frequent, sustained sleep-related hypoxia suggestive of hypoventilation was not seen in our patients.
  • Further prospective studies are needed to examine the frequency and scope of sleep disturbances in DM2.
  • [MeSH-major] Disorders of Excessive Somnolence / physiopathology. Myotonic Disorders / complications. Sleep Disorders / etiology

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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 23108384.001).
  • [ISSN] 1421-9913
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000135
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Dystrophia myotonica 2
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10. |||||..... 50%  Ucar ZZ, Taymaz Z, Erbaycu AE, Kirakli C, Tuksavul F, Guclu SZ: Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders. South Med J; 2009 Jul;102(7):693-700
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  • [Title] Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders.
  • BACKGROUND: Lactate may be useful in pointing out the higher risk subgroups in sleep-related breathing disorders (SRBD) with various patterns of hypoxemia.
  • We aimed to search whether morning and night lactate levels are related to apnea-hypopnea, hypoventilation, and hypoxemia in patients with SRBD and to compare it with patients without SRBD (No-SRBD).
  • SRBD patients had obstructive sleep apnea syndrome with or without sleep-related hypoventilation/hypoxemic conditions.
  • After an adjustment for age, gender, and body mass index, lactate levels before PSG were related to the apnea-hypopnea index (beta: 0.004, 95% CI: 0.000-0.008) and the rate of sleep-time spent under 90% oxygen saturation (T90%).
  • CONCLUSION: As a marker of tissue hypoxia, arterial lactate may be used to assess the severity of SRBD.
  • [MeSH-major] Anoxia / blood. Lactic Acid / blood. Sleep Apnea, Obstructive / blood. Sleep Apnea, Obstructive / diagnosis

  • HSDB. structure - LACTIC ACID.
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  • (PMID = 19487994.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biological Markers; 33X04XA5AT / Lactic Acid
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11. |||....... 34%  Vernet C, Redolfi S, Attali V, Konofal E, Brion A, Frija-Orvoen E, Pottier M, Similowski T, Arnulf I: Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms. Eur Respir J; 2011 Jul;38(1):98-105
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  • [Title] Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms.
  • 40 apnoeic patients, with (n = 20) and without (n = 20) RES, and 20 healthy controls underwent clinical interviews, cognitive and biological tests, polysomnography, a multiple sleep latency test, and 24-h sleep monitoring.
  • The marked subjective sleepiness in the RES group (mean ± sd score 16.4 ± 3) contrasted with moderately abnormal objective measures of sleepiness (90% of patients with RES had daytime sleep latencies >8 min).
  • Compared with patients without RES, the patients with RES had more fatigue, lower stage N3 percentages, more periodic leg movements (without arousals), lower mean sleep latencies and longer daytime sleep periods.
  • The association between RES, periodic leg movements, apathy and depressive mood parallels the post-hypoxic lesions in noradrenaline, dopamine and serotonin systems in animals exposed to intermittent hypoxia.
  • [MeSH-major] Disorders of Excessive Somnolence / diagnosis. Sleep Apnea, Obstructive / diagnosis
  • [MeSH-minor] Adult. Aged. Anoxia. Case-Control Studies. Fatigue. Female. France. Humans. Male. Middle Aged. Phenotype. Polysomnography. Sleep. Sleep Stages. Time Factors

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  • [CommentIn] Eur Respir J. 2011 Jul;38(1):7-8 [21719496.001]
  • [CommentIn] Eur Respir J. 2012 Jan;39(1):226-7; author reply 227-8 [22210820.001]
  • (PMID = 21406511.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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12. |||....... 34%  Nespoulet H, Wuyam B, Tamisier R, Saunier C, Monneret D, Remy J, Chabre O, Pépin JL, Lévy P: Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep. Eur Respir J; 2012 Sep;40(3):673-80
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  • [Title] Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep.
  • We compared 12 AMS-susceptible individuals with recurrent and severe symptoms (AMS+) with 12 "AMS-nonsusceptible" subjects (AMS-), assessing sleep-breathing disorders in simulated altitude as well as chemoresponsive and pulmonary vasoconstrictive responses to hypoxia.
  • During exposure to simulated altitude, mean blood oxygen saturation during sleep was lower in AMS+ subjects (81.6 ± 2.6 versus 86.0 ± 2.4%, p<0.01), associated with a lower central apnoea/hypopnoea index (18.2 ± 18.1 versus 33.4 ± 24.8 events · h(-1) in AMS+ and AMS- subjects, respectively; p=0.038).
  • This represented the only significant and independent predictive factor for altitude intolerance, despite a higher increase in pulmonary artery systolic pressure in response to hypoxia, a lower lung diffusing capacity and a higher endothelin-1 level at baseline in AMS+ subjects (p<0.05).
  • AMS+ subjects were more hypoxaemic whilst exhibiting fewer respiratory events during sleep owing to lower hypoxic (isocapnic) chemoresponsiveness.
  • [MeSH-major] Altitude Sickness / physiopathology. Anoxia / physiopathology. Oxygen / blood. Sleep / physiology

  • HSDB. structure - OXYGEN.
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  • (PMID = 22523356.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Endothelin-1; S88TT14065 / Oxygen
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13. |||....... 34%  Donovan L, Welford SM, Haaga J, LaManna J, Strohl KP: Hypoxia--implications for pharmaceutical developments. Sleep Breath; 2010 Dec;14(4):291-8
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  • [Title] Hypoxia--implications for pharmaceutical developments.
  • Lowered oxygen availability (hypoxia) is theoretically important in the consideration of pharmacology because (1) hypoxia can alter cellular function and thereby the therapeutic effectiveness of the agent, (2) therapeutic agents may potentiate or protect against hypoxia-induced pathology, (3) hypoxic conditions may potentiate or mitigate drug-induced toxicity, (4) hypoxia may alter drug metabolism and thereby therapeutic effectiveness, and (5) therapeutic agents might alter the relative coupling of blood flow and energy metabolism in an organ.
  • The prototypic biochemical effect of hypoxia is related to its known role as a cofactor in a number of enzymatic reactions, e.g., oxidases and oxygenases, which are affected independently from the bioenergetic effect of low oxygen on energetic functions.
  • With chronic hypoxia, many of these processes are reversed, suggesting that hypoxia induces the drug-metabolizing systems.
  • Support for this comes from observations that hypoxia can induce the hypoxic inducible factors which in turn alters transcription and function of some but not all cytochrome P-450 isoforms.
  • Hypoxia is identified as a cofactor in cancer expression and metastatic potential.
  • Thus, the effects of hypoxia play an important role in pharmacology, and the signaling pathways that are affected by hypoxia could become new targets for novel therapy or avenues for prevention.
  • [MeSH-minor] Biotransformation / physiology. Cell Hypoxia / physiology. Cytochrome P-450 Enzyme System / physiology. Cytochromes c / physiology. Humans. Metabolic Detoxication, Drug / physiology

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  • (PMID = 20625934.001).
  • [ISSN] 1522-1709
  • [Journal-full-title] Sleep & breathing = Schlaf & Atmung
  • [ISO-abbreviation] Sleep Breath
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R33 HL087340-01A1
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-43-6 / Cytochromes c; 9035-51-2 / Cytochrome P-450 Enzyme System
  • [Other-IDs] NLM/ NIHMS223042; NLM/ PMC3236526
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14. |||....... 34%  Dale-Nagle EA, Hoffman MS, MacFarlane PM, Satriotomo I, Lovett-Barr MR, Vinit S, Mitchell GS: Spinal plasticity following intermittent hypoxia: implications for spinal injury. Ann N Y Acad Sci; 2010 Jun;1198:252-9
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  • [Title] Spinal plasticity following intermittent hypoxia: implications for spinal injury.
  • One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH).
  • pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain-derived neurotrophic factor, activation of its high-affinity receptor, tropomyosin-related kinase B, and extracellular-related kinase mitogen-activated protein kinase signaling in or near phrenic motor neurons.
  • Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury.
  • [MeSH-minor] Animals. Brain-Derived Neurotrophic Factor / physiology. Cervical Vertebrae / injuries. Enzyme Activation. Humans. Hypertension / etiology. Learning Disorders / etiology. Learning Disorders / physiopathology. Phrenic Nerve / physiology. Phrenic Nerve / physiopathology. Protein Kinase C / metabolism. Rats. Receptors, Serotonin, 5-HT2 / physiology. Respiratory Physiological Phenomena. Sleep Disorders / etiology. Sleep Disorders / physiopathology

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  • (PMID = 20536940.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / F31 HL092785; United States / NHLBI NIH HHS / HL / F31 HL092785-02; United States / NHLBI NIH HHS / HL / HL69064; United States / NHLBI NIH HHS / HL / HL80209; United States / NINDS NIH HHS / NS / NS05777; United States / NINDS NIH HHS / NS / P01 NS057778-040001; United States / NINDS NIH HHS / NS / P01 NS057778-05; United States / NHLBI NIH HHS / HL / R01 HL080209-06; United States / NHLBI NIH HHS / HL / R37 HL069064-10; United States / NIGMS NIH HHS / GM / T32 GM008692; United States / NHLBI NIH HHS / HL / T32 HL007654-25; United States / NHLBI NIH HHS / HL / T32HL07654
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Receptors, Serotonin, 5-HT2; EC 2.7.11.13 / Protein Kinase C
  • [Number-of-references] 60
  • [Other-IDs] NLM/ NIHMS261289; NLM/ PMC3030965
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15. |||....... 34%  Stettner GM, Fenik VB, Kubin L: Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons. J Appl Physiol (1985); 2012 Jan;112(2):305-12
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  • [Title] Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons.
  • In obstructive sleep apnea patients, elevated activity of the lingual muscles during wakefulness protects the upper airway against occlusions.
  • A possibly related form of respiratory neuroplasticity is present in rats exposed to acute and chronic intermittent hypoxia (CIH).
  • [MeSH-major] Adrenergic Neurons / metabolism. Anoxia / physiopathology. Hypoglossal Nerve / physiology. Motor Neurons / physiology. Receptors, Adrenergic / metabolism. Sleep Apnea, Obstructive

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  • (PMID = 22016369.001).
  • [ISSN] 1522-1601
  • [Journal-full-title] Journal of applied physiology (Bethesda, Md. : 1985)
  • [ISO-abbreviation] J. Appl. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-047600
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic alpha-1 Receptor Antagonists; 0 / Receptors, Adrenergic; X4W3ENH1CV / Norepinephrine; XM03YJ541D / Prazosin
  • [Other-IDs] NLM/ PMC3349609
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16. |||||..... 49%  Inamoto S, Yoshioka T, Yamashita C, Miyamura M, Mori T, Ukimura A, Matsumoto C, Matsumura Y, Kitaura Y, Hayashi T: Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. Hypertens Res; 2010 Jun;33(6):579-86
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice.
  • We have reported previously that intermittent hypoxia related to sleep apnea induces cardiovascular remodeling secondary to the oxidative stress.
  • The aim of this study was to examine the effect of pitavastatin as an antioxidant to prevent intermittent hypoxia-induced left ventricular (LV) remodeling in mice without hypercholesterolemia.
  • Eight-week-old male C57BL/6J mice (n=35) were exposed to intermittent hypoxia (30 s exposure to 5% oxygen, followed by 30 s exposure to 21% oxygen) for 8 h per day during the daytime or maintained under normoxic conditions; in addition, they were either treated with pitavastatin (3 mg kg(-1) per day) or vehicle for 10 days.
  • Intermittent hypoxia significantly increased the expression levels of 4-hydroxy-2-nonenal (4-HNE) proteins, TNF-alpha and TGF-beta mRNA, and also the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling (TUNEL)-positive myocardial cells in the LV myocardium.
  • Treatment with pitavastatin significantly suppressed the expression levels of the 4-HNE proteins, cytokines, superoxide production and TUNEL-positive myocardial cells in the LV myocardium, consequently attenuating the hypoxia-induced histological changes.
  • Pitavastatin preserved, at least partially, the morphological structure of the LV myocardium in lean mice exposed to intermittent hypoxia, through its antioxidant effect.
  • [MeSH-major] Anoxia / complications. Antioxidants / therapeutic use. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Oxidative Stress / drug effects. Quinolines / therapeutic use. Sleep Apnea Syndromes / complications. Ventricular Remodeling / drug effects

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  • [CommentIn] Hypertens Res. 2010 Jun;33(6):535-6 [20448637.001]
  • (PMID = 20300107.001).
  • [ISSN] 1348-4214
  • [Journal-full-title] Hypertension research : official journal of the Japanese Society of Hypertension
  • [ISO-abbreviation] Hypertens. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antioxidants; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Quinolines; 0 / Transforming Growth Factor beta; 0 / Tumor Necrosis Factor-alpha; 29343-52-0 / 4-hydroxy-2-nonenal; 97C5T2UQ7J / Cholesterol; M5681Q5F9P / pitavastatin
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17. |||||..... 48%  de Castro-Silva C, de Bruin VM, Cavalcante AG, Bittencourt LR, de Bruin PF: Nocturnal hypoxia and sleep disturbances in cystic fibrosis. Pediatr Pulmonol; 2009 Nov;44(11):1143-50
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  • [Title] Nocturnal hypoxia and sleep disturbances in cystic fibrosis.
  • Disrupted sleep and nocturnal hypoxia are common in cystic fibrosis (CF).
  • However, the predictors of nocturnal hypoxia in CF are still controversial.
  • In order to identify the risk factors for nocturnal desaturation and sleep disturbances, we carried out a clinical and polysomnographic investigation of CF patients.
  • During sleep, five CF cases with clinical lung disease (15%) had SaO(2) <90% during more than 30% of total sleep time and 11 cases (36.6%) had a nadir SaO(2) below 85%.
  • FEV1 values for CF cases with clinical lung disease were related to nadir SaO(2) (P < 0.03) and to mean SaO(2) (P = 0.02).
  • A receiver operating characteristic (ROC) analysis determined FEV1 at 64% to be predictive of nocturnal desaturation as defined by minimum SaO(2) <85% (sensitivity = 92.3%; specificity = 77.3%) or SaO(2) <90% for 30% of sleep time (sensitivity = 81.8%; specificity = 85.2%).
  • Frequency of impaired sleep was not different in CF cases with (N = 2) and without significant lung disease (N = 5, P = 0.53).
  • Sleep architecture was not significantly different between the two groups.
  • Sleep apnea was present in three CF cases with clinical lung disease and in one case without significant lung disease.
  • In summary, desaturation during sleep can be predicted by FEV1 <64% with good sensitivity and specificity.
  • There are no significant differences in sleep architecture between clinically stable CF cases with and without significant lung disease.
  • [MeSH-major] Anoxia / diagnosis. Anoxia / etiology. Cystic Fibrosis / complications. Sleep Apnea Syndromes / diagnosis. Sleep Apnea Syndromes / etiology

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  • (PMID = 19824056.001).
  • [ISSN] 1099-0496
  • [Journal-full-title] Pediatric pulmonology
  • [ISO-abbreviation] Pediatr. Pulmonol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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18. |||||..... 48%  Ramar K, Caples SM: Vascular changes, cardiovascular disease and obstructive sleep apnea. Future Cardiol; 2011 Mar;7(2):241-9
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  • [Title] Vascular changes, cardiovascular disease and obstructive sleep apnea.
  • Vascular changes related to obstructive sleep apnea (OSA) can lead to chronic cardiovascular consequences such as hypertension.
  • The cardiovascular consequences are owing to nocturnal perturbations related to intrathoracic pressure changes, intermittent hypoxia, sympathetic neural activation, endothelial dysfunction, oxidative stress and systemic inflammation.
  • Intermittent hypoxia due to sleep-related events in OSA activates the renin-angiotensin system and increases the levels of endothelin-1.
  • Intermittent hypoxia also results in oxidative stress, as evidenced by elevated levels of xanthine oxidoreductase, lipid peroxidation and the presence of reactive oxygen species.
  • [MeSH-major] Cardiovascular Diseases / etiology. Endothelium, Vascular / physiopathology. Sleep Apnea, Obstructive / complications. Vasodilation / physiology

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  • (PMID = 21453030.001).
  • [ISSN] 1744-8298
  • [Journal-full-title] Future cardiology
  • [ISO-abbreviation] Future Cardiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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19. ||||...... 37%  Bell HJ, Ferguson C, Kehoe V, Haouzi P: Hypocapnia increases the prevalence of hypoxia-induced augmented breaths. Am J Physiol Regul Integr Comp Physiol; 2009 Feb;296(2):R334-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hypocapnia increases the prevalence of hypoxia-induced augmented breaths.
  • Augmented breaths promote respiratory instability and have been implicated in triggering periods of sleep-disordered breathing.
  • Since respiratory instability is well known to be exacerbated by hypocapnia, we asked whether one of the destabilizing effects of hypocapnia might be related to an increased prevalence of augmented breaths.
  • With this question in mind, we first sought to determine whether hypoxia-induced augmented breaths are more prevalent when hypocapnia is also present.
  • We found that the prevalence of augmented breaths was dramatically increased during hypocapnic-hypoxia compared with room air conditions.
  • When hypocapnia was prevented during exposure to hypoxia by adding 5% CO2 to the inspired air, the rate of occurrence of augmented breaths was no greater than that observed in room air.
  • We conclude that in spontaneously breathing rats, hypoxia promotes the generation of augmented breaths, but only in poikilocapnic conditions, where hypocapnia develops.
  • Our results, therefore, reveal a means by which CO2 exerts a stabilizing influence on breathing, which may be of particular relevance during sleep in conditions commonly associated with respiratory instability.

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  • (PMID = 19091914.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide; S88TT14065 / Oxygen
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20. ||||...... 36%  Lombardi C, Meriggi P, Agostoni P, Faini A, Bilo G, Revera M, Caldara G, Di Rienzo M, Castiglioni P, Maurizio B, Gregorini F, Mancia G, Parati G, HIGHCARE Investigators: High-altitude hypoxia and periodic breathing during sleep: gender-related differences. J Sleep Res; 2013 Jun;22(3):322-30
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  • [Title] High-altitude hypoxia and periodic breathing during sleep: gender-related differences.
  • High-altitude exposure is characterized by the appearance of periodic breathing during sleep.
  • Only limited evidence is available, however, on the presence of gender-related differences in this breathing pattern.
  • Females started to present a significant number of central sleep apneas only at the highest reached altitude.
  • [MeSH-major] Anoxia / complications. Monitoring, Ambulatory / instrumentation. Sleep / physiology. Sleep Apnea, Central / physiopathology

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  • [Copyright] © 2013 European Sleep Research Society.
  • (PMID = 23294420.001).
  • [ISSN] 1365-2869
  • [Journal-full-title] Journal of sleep research
  • [ISO-abbreviation] J Sleep Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Benzimidazoles; 0 / Benzoates; 0 / Placebos; S88TT14065 / Oxygen; U5SYW473RQ / telmisartan
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21. ||||...... 35%  Lavie L, Polotsky V: Cardiovascular aspects in obstructive sleep apnea syndrome--molecular issues, hypoxia and cytokine profiles. Respiration; 2009;78(4):361-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiovascular aspects in obstructive sleep apnea syndrome--molecular issues, hypoxia and cytokine profiles.
  • Obstructive sleep apnea syndrome (OSAS), which is a highly prevalent breathing disorder in sleep, is an independent risk factor for cardiovascular morbidity and mortality.
  • Results from clinical studies as well as animal models and cell culture studies utilizing intermittent hypoxia implicate oxidative stress and inflammation in the pathogenesis of OSAS.
  • The current review highlights some of the recent findings on oxidative stress and inflammation in OSAS with specific emphasis on the role of inflammatory pathway activation and expression of cytokines and their possible role in OSAS-related cardiovascular morbidity.
  • [MeSH-major] Cardiovascular Diseases / etiology. Cytokines / metabolism. Oxidative Stress. Sleep Apnea, Obstructive / complications. Sleep Apnea, Obstructive / metabolism

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  • [Copyright] Copyright © 2009 S. Karger AG, Basel.
  • (PMID = 19786735.001).
  • [ISSN] 1423-0356
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL080105; United States / NHLBI NIH HHS / HL / R01 HL080105-05A1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cytokines; 0 / Transcription Factors
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22. ||||...... 35%  Hoshikawa M, Uchida S, Ganeko M, Sumitomo J, Totoki M, Kojima T, Nakamura Y, Kawahara T: Sleep quality under mild hypoxia in men with low hypoxic ventilatory response. Eur J Sport Sci; 2014;14 Suppl 1:S205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sleep quality under mild hypoxia in men with low hypoxic ventilatory response.
  • The present study evaluated whether slow-wave sleep and whole-night delta power of the non-rapid eye movement (NREM) sleep electroencephalogram (EEG) decrease during sleep at a simulated altitude of 2000 m, and whether such changes related to measures of hypoxic ventilatory response (HVR).
  • This study consisted of two parts; in the first, HVR was measured in 41 subjects and each seven subjects with the lowest or the highest HVR were selected for the subsequent sleep study.
  • Hypoxia decreased SpO2 and increased respiratory disturbances for both groups.
  • The low HVR group, but not the high HVR group, showed decreases in the whole-night delta power of NREM sleep EEG under hypoxia.
  • On the other hand, two subjects in the high HVR group, who showed relatively high apnoea indices, also showed lower SpO2 nadirs and decreases in the whole-night delta power under hypoxia.
  • These results suggest that acute hypoxia equivalent to that at a 2000 m altitude decreases slow-wave sleep in individuals that show low HVR.
  • However, low HVR may not be the only, but one of some factors that decrease the whole-night delta power under hypoxia.
  • Therefore, it was not sufficient to identify individuals likely to be susceptible to deteriorated sleep quality at a simulated altitude of 2000 m only using the HVR test.

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  • (PMID = 24444208.001).
  • [ISSN] 1536-7290
  • [Journal-full-title] European journal of sport science
  • [ISO-abbreviation] Eur J Sport Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. |||....... 35%  Chai LP, Xie X, Zeng YH, Wang ZF, Tu XP: [Rapid eye movement-related and none rapid eye movement-related classification in obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Feb;45(2):105-10
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  • [Title] [Rapid eye movement-related and none rapid eye movement-related classification in obstructive sleep apnea hypopnea syndrome].
  • OBJECTIVE: To study the value of a new measurement that divided obstructive sleep apnea-hypopnea syndrome (OSAHS) into rapid-eye-movement (REM) related and non-rapid-eye-movement (NREM) related subgroups.
  • METHODS: According to Siddiqui classification, 137 adult patients with OSHAS were diagnosed as REM-related OSAHS [REM apnea hypopnea index (AHI)/NREM AHI > 1] or NREM-related OSAHS (REM AHI/NREM AHI < 1).
  • (1) There were 72 cases defined as REM-related OSAHS (52.6%) and 65 cases defined as NREM-related OSAHS (47.4%). (2) In all cases, total AHI and NREM AHI in REM-related OSAHS were significantly lower than those in NREM-related OSAHS, while lowest arterial oxygen saturation (LSaO₂), REM LSaO₂ and NREM LSaO₂ were significantly higher than those in NREM-related OSAHS (t were -6.466, -7.638, 3.426, 2.472, 4.873 respectively, P < 0.05).
  • No significance was found in sleep structure, REM AHI and REM LSaO₂ between REM-related and NREM-related OSAHS (P > 0.05). (3) Given the severity of OSHAS, the constituent ratio of REM-related OSAHS decreased (77.8%, 61.5%, 37.3%) from mild to severe OSAHS, while that of NREM-related OSAHS rose (22.7%, 38.5%, 62.7%; chi² = 16.996, P < 0.01).
  • In mild and moderate groups, REM LSaO₂ of REM-related OSAHS was significantly lower than those in NREM-related OSAHS (t were -4.273 and -2.136, P < 0.05), while the differences of total AHI and LSaO₂, NREM LSaO₂ between these two types were not significant.
  • In severe group, AHI in NREM-related OSAHS was significantly higher than that in REM-related OSAHS, while LSaO₂, REM LSaO₂ and NREM LSaO₂ was significantly lower than those in REM-related OASHS (t were -4.943, 2.574, 1.996, 3.571, P ≤ 0.05). (4) There was no significance in sleeping latency and efficiency between REM-related and NREM-related OSHAS.
  • CONCLUSIONS: REM-related OSHAS mainly exists in mild and moderate OSHAS, while NREM-related one mainly exists in severe OSHAS.
  • NREM-related OSAHS may be more severe in AHI and hypoxia than REM-related one.
  • Whenever obstructive apnea happened in REM or NREM period, its impacts on sleep structure, efficiency and latency have no difference.
  • [MeSH-major] Sleep Apnea, Obstructive / classification. Sleep, REM
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Polysomnography. Sleep Stages. Young Adult

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  • (PMID = 20398503.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. |||....... 34%  Hui-guo L, Kui L, Yan-ning Z, Yong-jian X: Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia. Sleep Med; 2010 Feb;11(2):205-12
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  • [Title] Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia.
  • RATIONALE: The long-term intermittent hypoxia (LTIH) that characterizes sleep-disordered breathing impairs spatial learning and increases oxidative stress in rodents.
  • In untreated animals, LTIH exposure was related to increase of MDA levels in comparison to sham LTIH animals, and apocynin-treated animal exposure to LTIH showed reduction in MDA levels.
  • NADPH oxidase up-expression is closely associated with oxidative processes in LTIH rats, and inhibition of NADPH oxidase activity may hopefully serve as a useful strategy for cognitive function impairment from chronic intermittent hypoxia.

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  • [Copyright] 2009 Elsevier B.V. All rights reserved.
  • (PMID = 20083433.001).
  • [ISSN] 1878-5506
  • [Journal-full-title] Sleep medicine
  • [ISO-abbreviation] Sleep Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Acetophenones; 4Y8F71G49Q / Malondialdehyde; B6J7B9UDTR / acetovanillone; EC 1.15.1.1 / Superoxide Dismutase; EC 1.6.3.1 / NADPH Oxidase; EC 1.6.3.1 / neutrophil cytosolic factor 1; EC 1.6.3.1 / p22-phox protein, rat
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25. |||....... 33%  Roisman G, Ibrahim I, Escourrou P: [Why and how to diagnose sleep respiratory disorders?]. Rev Pneumol Clin; 2009 Aug;65(4):203-13
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  • [Title] [Why and how to diagnose sleep respiratory disorders?].
  • Gas exchange abnormalities occur firstly during sleep in restrictive and obstructive chronic respiratory failure.
  • Nocturnal hypoxemia is often a revealing feature of a sleep-related hypoventilation/hypoxemia syndrome in patients who will have later a diurnal hypoxemia.
  • On the other hand, sleep may induce breathing abnormalities in individuals without lung diseases, like in obstructive sleep apnea syndrome (OSAS).
  • In OSAS, repeated closure and/or narrowing of the pharynx during sleep increases the inspiratory effort and induces sleep fragmentation.
  • Besides its direct consequences on sleep, OSAS is also associated with an increased risk of cardiovascular morbi-mortality.
  • Reduced daytime alertness and cognitive functions are usually present in patients with sleep-disordered breathing.
  • These features are believed to be related to both sleep fragmentation and nocturnal hypoxia/hypercapnia.
  • Sleep-related hypoventilation/hypoxemia and pharyngeal obstructive events may occur together in patients with respiratory insufficiency, especially in obese and/or chronic obstructive pulmonary disease (COPD) subjects.
  • A correct qualitative and quantitative assessment of sleep-disordered breathing may only be performed by recording specific physiological signals during sleep.
  • [MeSH-major] Sleep Apnea Syndromes / diagnosis

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  • (PMID = 19789046.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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26. |||....... 33%  Rambaud C, Guilleminault C: Death, nasomaxillary complex, and sleep in young children. Eur J Pediatr; 2012 Sep;171(9):1349-58
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  • [Title] Death, nasomaxillary complex, and sleep in young children.
  • This is an investigation of anatomical and sleep history risk factors that were associated with abrupt sleep-associated death in seven children with good pre-mortem history.
  • Seven young children with abrupt deaths and information on health status, sleep history, death scene report, and autopsy performed in a specialized unit dedicated to investigation of abrupt death in young children were investigated Seven age and gender matched living children with obstructive-sleep-apnea (OSA) were compared to the findings obtained from the dead children.
  • History revealed presence of chronic indicators of abnormal sleep in all cases prior death and history of an acute, often mild, rhinitis just preceding death in several.
  • All children were concluded to have died of hypoxia during sleep.
  • Their presence should lead to greater attention to sleep-related complaints that may be present very early in life and indicate impairment of well been and presence of sleep disruption.
  • [MeSH-major] Anoxia / mortality. Death, Sudden / etiology. Maxilla / pathology. Nose / pathology. Sleep Apnea, Obstructive / complications

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  • (PMID = 22492014.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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27. |||....... 32%  Csábi E, Janacsek K, Várszegi M, Németh D: [Different effect of sleep on working memory and skill learning: cognitive function in obstructive sleep apnea]. Psychiatr Hung; 2011;26(2):78-86
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  • [Title] [Different effect of sleep on working memory and skill learning: cognitive function in obstructive sleep apnea].
  • In obstructive sleep apnea syndrome (OSAS) hypoxia and sleep deprivation lead to neuropsychological impairments.
  • Our goal in this study to evaluate working memory and skill learning to get a complex picture about cortical and sub-cortical function in patients with sleep apnea.
  • These findings suggest that sleep has less influence on the functions related to sub-cortical structures like cortical functions.
  • [MeSH-major] Cognition. Cognition Disorders / psychology. Learning. Memory, Short-Term. Motor Skills. Sleep. Sleep Apnea, Obstructive / psychology

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  • (PMID = 21653993.001).
  • [ISSN] 0237-7896
  • [Journal-full-title] Psychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata
  • [ISO-abbreviation] Psychiatr Hung
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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28. |||....... 32%  Querido JS, Sheel AW, Cheema R, Van Eeden S, Mulgrew AT, Ayas NT: Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans. Sleep Breath; 2012 Sep;16(3):657-62
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  • [Title] Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans.
  • PURPOSE: Obstructive sleep apnea (OSA) is a common disease which is associated with elevated inflammatory markers and adhesion molecules, possibly due to nightly intermittent hypoxia (IH).
  • METHODS: Healthy, young male subjects (n = 9; 24 ± 2 years) were exposed to a single daily isocapnic hypoxia exposure (oxyhemoglobin saturation = 80%, 1 h/day) for 10 consecutive days.
  • The mean oxyhemoglobin saturation was 80.8 ± 1.6% during the hypoxia exposures.
  • CONCLUSIONS: These findings suggest that (1) a more substantial or a different pattern of hypoxemia might be necessary to activate systemic inflammation, (2) the system may need to be primed before hypoxic exposure, or (3) increases in inflammatory markers in patients with OSA may be more related to other factors such as obesity or nocturnal arousal.
  • [MeSH-major] Anoxia / physiopathology. Inflammation Mediators / metabolism. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 21743982.001).
  • [ISSN] 1522-1709
  • [Journal-full-title] Sleep & breathing = Schlaf & Atmung
  • [ISO-abbreviation] Sleep Breath
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Inflammation Mediators; S88TT14065 / Oxygen
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29. |||....... 32%  Arnaud C, Dematteis M, Pepin JL, Baguet JP, Lévy P: Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin Immunopathol; 2009 Jun;31(1):113-25
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  • [Title] Obstructive sleep apnea, immuno-inflammation, and atherosclerosis.
  • Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder leading to cardiovascular and metabolic complications.
  • OSA is also a multicomponent disorder, with intermittent hypoxia (IH) as the main trigger for the associated cardiovascular and metabolic alterations.
  • Indeed, recurrent pharyngeal collapses during sleep lead to repetitive sequences of hypoxia-reoxygenation.
  • Atherosclerosis has been found in OSA patients free of other cardiovascular risk factors and is related to the severity of nocturnal hypoxia.
  • The intimate molecular mechanisms are still largely unknown, and their understanding may contribute to delineate new targets for prevention strategies and/or development of new treatment of OSA-related atherosclerosis, especially in patients at risk for cardiovascular disease.
  • [MeSH-major] Atherosclerosis / immunology. Sleep Apnea, Obstructive / immunology

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  • (PMID = 19404644.001).
  • [ISSN] 1863-2300
  • [Journal-full-title] Seminars in immunopathology
  • [ISO-abbreviation] Semin Immunopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adipokines
  • [Number-of-references] 161
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30. |||....... 32%  Xiang YH, Su XL, Hu CP, Luo YQ, He RX: [A study of the related pathways of oxidative stress in chronic intermittent hypoxia rats and the effect of N-acetylcysteine]. Zhonghua Jie He He Hu Xi Za Zhi; 2010 Dec;33(12):912-6
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  • [Title] [A study of the related pathways of oxidative stress in chronic intermittent hypoxia rats and the effect of N-acetylcysteine].
  • OBJECTIVE: To study the relation of oxidative stress with systolic blood pressure (SBP) and renin-agiotensin system (RAS) in a rat model of chronic intermittent hypoxia (CIH), and to investigate the preventive effect and mechanism of N-acetylcysteine (NAC) in CIH-induced hypertension.
  • CIH rats were subjected to alternating cycles of hypoxia (6%-8% O2 in N2 for 20-25 s) and normoxia (21% O2 in N2 for 2 min) every 180 s for 7 h per day.
  • The imbalance of RAS in CIH rats was related with oxidative stress.
  • [MeSH-minor] Animals. Blood Pressure. Male. Rats. Rats, Sprague-Dawley. Renin-Angiotensin System. Sleep Apnea, Obstructive / metabolism

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  • (PMID = 21211411.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; WYQ7N0BPYC / Acetylcysteine
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31. |||....... 32%  Jun J, Polotsky VY: Metabolic consequences of sleep-disordered breathing. ILAR J; 2009;50(3):289-306
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  • [Title] Metabolic consequences of sleep-disordered breathing.
  • There is increasing evidence of a causal relationship between sleep-disordered breathing and metabolic dysfunction.
  • Excess caloric intake is indisputably the key driver of MetS, but other environmental and genetic factors likely play a role; in particular, obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may induce or exacerbate various aspects of MetS.
  • In the most widely used model, which involves exposing rodents to IH during their sleep phase, the IH alters circadian glucose homeostasis, impairs muscle carbohydrate uptake, induces hyperlipidemia, and upregulates cholesterol synthesis enzymes.
  • Mechanisms for these effects are not yet fully understood, but are likely related to energy-conserving adaptations to hypoxia, which is a strong catabolic stressor.
  • [MeSH-major] Metabolic Diseases / etiology. Sleep Apnea Syndromes / complications
  • [MeSH-minor] Animals. Anoxia / complications. Anoxia / physiopathology. Dyslipidemias / etiology. Dyslipidemias / physiopathology. Humans. Liver Diseases / etiology. Liver Diseases / physiopathology. Mice. Obesity / etiology. Obesity / physiopathology. Rats. Sleep Deprivation / etiology. Sleep Deprivation / physiopathology

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  • (PMID = 19506316.001).
  • [ISSN] 1930-6180
  • [Journal-full-title] ILAR journal / National Research Council, Institute of Laboratory Animal Resources
  • [ISO-abbreviation] ILAR J
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / 5P50HL084945; United States / NHLBI NIH HHS / HL / R01 HL80105; United States / NHLBI NIH HHS / HL / T32 HL07534
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 239
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32. |||....... 32%  Onen F, Onen H: [Obstructive sleep apnea and cognitive impairment in the elderly]. Psychol Neuropsychiatr Vieil; 2010 Sep;8(3):163-9
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  • [Title] [Obstructive sleep apnea and cognitive impairment in the elderly].
  • Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repeated episodes of upper airway obstruction during sleep that result in intermittent hypoxemia and arousal.
  • OSAS causes hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage resulting from reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss.
  • OSAS-related cognitive dysfunction has been shown in a variety of domains including attention, executive functioning, motor efficiency, working memory, and long-term episodic memory.
  • Proposed mechanisms include hypoxemia, sleep fragmentation and inflammatory process, but it remains unclear which mechanisms underlie the relationship between OSAS and disturbances in the different cognitive domains.
  • [MeSH-major] Cognition Disorders / etiology. Sleep Apnea, Obstructive / diagnosis
  • [MeSH-minor] Aged. Alzheimer Disease / diagnosis. Alzheimer Disease / epidemiology. Alzheimer Disease / etiology. Brain Damage, Chronic / complications. Brain Damage, Chronic / diagnosis. Brain Damage, Chronic / epidemiology. Continuous Positive Airway Pressure. Cross-Sectional Studies. Humans. Hypoxia, Brain / complications. Hypoxia, Brain / diagnosis. Hypoxia, Brain / epidemiology. Neuropsychological Tests

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  • (PMID = 20739254.001).
  • [ISSN] 1760-1703
  • [Journal-full-title] Psychologie & neuropsychiatrie du vieillissement
  • [ISO-abbreviation] Psychol Neuropsychiatr Vieil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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33. |||....... 31%  Estrada KD, Chesler NC: Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia. Biomech Model Mechanobiol; 2009 Aug;8(4):263-72
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  • [Title] Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia.
  • Collagen accumulation likely contributes to increased vascular and airway impedance in hypoxia-induced pulmonary hypertension (HPH).
  • To better understand the individual contributions of fibrillar (FB) and basement membrane (BM) collagen, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) to pulmonary vascular and airway remodeling in HPH, we investigated the temporal changes in gene and protein expression in the lungs of mice exposed to hypoxia for 0, 3, 6, 10 and 15 days.
  • The earliest and largest change in gene expression was of type I FB collagen, which was significantly increased over control levels at 6, 10 and 15 days of hypoxia (p < 0.05).
  • Type III FB and type IV BM collagen were increased at 10 and 15 days of hypoxia (p < 0.05); MMP and TIMP gene expression levels were typically higher but sometimes lower than control levels at various time points.
  • Collagen protein content was increased in whole lungs as early as 6 days of hypoxia and increased monotonically with longer exposures.
  • These results provide insight into the patterns of gene and protein expression relevant to collagen accumulation in the lung in response to chronic hypoxia, through which we can develop a better understanding of the time course of changes in matrix biology and biomechanics that occur in HPH.

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  • (PMID = 18642127.001).
  • [ISSN] 1617-7940
  • [Journal-full-title] Biomechanics and modeling in mechanobiology
  • [ISO-abbreviation] Biomech Model Mechanobiol
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL086939; United States / NHLBI NIH HHS / HL / R01 HL086939-01A1; United States / NHLBI NIH HHS / HL / R01 HL086939-02; United States / NHLBI NIH HHS / HL / R01HL086939
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-34-5 / Collagen; RMB44WO89X / Hydroxyproline
  • [Other-IDs] NLM/ NIHMS60119; NLM/ PMC2718063
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34. |||....... 31%  Sun W, Yin X, Wang Y, Tan Y, Cai L, Wang B, Cai J, Fu Y: Intermittent hypoxia-induced renal antioxidants and oxidative damage in male mice: hormetic dose response. Dose Response; 2012;11(3):385-400
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  • [Title] Intermittent hypoxia-induced renal antioxidants and oxidative damage in male mice: hormetic dose response.
  • Obstructive sleep apnea causes cardiovascular disease via chronic intermittent hypoxia (IH), which may be related to oxidative stress.
  • Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important cellular defense mechanism against oxidative stress by regulating its down-stream multiple antioxidants.

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  • (PMID = 23983666.001).
  • [ISSN] 1559-3258
  • [Journal-full-title] Dose-response : a publication of International Hormesis Society
  • [ISO-abbreviation] Dose Response
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3748850
  • [Keywords] NOTNLM ; Intermittent hypoxia / Nrf2 / kidney hypoxic damage / metallothionein
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35. |||....... 31%  Gonzalez-Martín MC, Vega-Agapito MV, Conde SV, Castañeda J, Bustamante R, Olea E, Perez-Vizcaino F, Gonzalez C, Obeso A: Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input. J Cell Physiol; 2011 Aug;226(8):1961-9
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  • [Title] Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input.
  • Obstructive sleep apnea is a frequent medical condition consisting in repetitive sleep-related episodes of upper airways obstruction and concurrent events of arterial blood hypoxia.
  • There is a frequent association of cardiovascular diseases and other pathologies to this condition conforming the obstructive sleep apnea syndrome (OSAS).
  • Laboratory models of OSAS consist in animals exposed to repetitive episodes of intermittent hypoxia (IH) which also develop cardiovascular pathologies, mostly hypertension.
  • The overall OSAS pathophysiology appears to be linked to the repetitive hypoxia, which would cause a sensitization of carotid body (CB) chemoreflex and chemoreflex-driven hyperreactivity of the sympathetic nervous system.
  • The efferent activity was measured as ventilation in normoxia, hypoxia, and hypercapnia.
  • Findings indicate a sensitization of the CB function to hypoxia evidenced by exaggerated chemoreceptor cell and CB afferent activity.
  • [MeSH-minor] Animals. Hypercapnia / physiopathology. Hypertension / physiopathology. Male. Norepinephrine / metabolism. Norepinephrine / physiology. Rats. Rats, Wistar. Renal Artery / physiopathology. Sleep Apnea, Obstructive / physiopathology. Sympathetic Nervous System / physiopathology

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 21520047.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine
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36. |||....... 31%  Khan AM, Ashizawa S, Hlebowicz V, Appel DW: Anemia of aging and obstructive sleep apnea. Sleep Breath; 2011 Jan;15(1):29-34
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  • [Title] Anemia of aging and obstructive sleep apnea.
  • Among elderly with obstructive sleep apnea (OSA), hypoxic stimulation of erythropoiesis may obscure AOA.
  • Hemogram changes were compared to apnea-hypopnea index (AHI), respiratory effort related arousals (RERA), and duration patients slept with oxyhemoglobin saturation <89% (hypoxic time (HT)) and were assessed for correlative significance using Pearson coefficient correlation.
  • While these Hct changes did not correlate significantly with selected sleep-breathing variables, we remain intrigued by a possible AOA-OSA interaction.
  • We believe OSA inflammatory processes interact with OSA hypoxia-induced erythropoiesis.
  • [MeSH-major] Anemia / blood. Anemia / therapy. Sleep Apnea, Obstructive / blood. Sleep Apnea, Obstructive / therapy

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  • (PMID = 20162370.001).
  • [ISSN] 1522-1709
  • [Journal-full-title] Sleep & breathing = Schlaf & Atmung
  • [ISO-abbreviation] Sleep Breath
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Oxyhemoglobins; S88TT14065 / Oxygen
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37. |||....... 31%  Rukhadze I, Fenik VB, Benincasa KE, Price A, Kubin L: Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. Am J Respir Crit Care Med; 2010 Nov 15;182(10):1321-9
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  • [Title] Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus.
  • RATIONALE: Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness.
  • Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory drive to upper airway motoneurons.
  • We tested whether chronic intermittent hypoxia (CIH), a major pathogenic factor of OSA, affects aminergic innervation of XII motoneurons that innervate tongue-protruding muscles in a manner that could alter their airway-dilatory action.
  • [MeSH-minor] Animals. Cell Count. Humans. Male. Motor Neurons / pathology. Motor Neurons / physiology. Norepinephrine / physiology. Rats. Rats, Sprague-Dawley. Receptor, Serotonin, 5-HT2A / physiology. Receptors, Adrenergic, alpha-1 / physiology. Serotonin / physiology. Sleep Apnea, Obstructive / pathology. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 20622040.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-047600; United States / NHLBI NIH HHS / HL / HL-074385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Serotonin, 5-HT2A; 0 / Receptors, Adrenergic; 0 / Receptors, Adrenergic, alpha-1; 0 / Receptors, Serotonin; 333DO1RDJY / Serotonin; X4W3ENH1CV / Norepinephrine
  • [Other-IDs] NLM/ PMC3001268
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38. |||....... 31%  Sans Capdevila O, Wienberg P, Haag O, Cols M: [Comorbidities of sleep-disordered breathing in children]. Acta Otorrinolaringol Esp; 2010 Dec;61 Suppl 1:26-32
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  • [Title] [Comorbidities of sleep-disordered breathing in children].
  • Sleep-related respiratory disorders in children, especially childhood sleep apnea-hypopnea syndrome, are associated with a wide range of comorbidities affecting the central nervous system, cardiovascular and metabolic systems, and growth.
  • The two most important factors contributing to the physiopathology of this disorder are intermittent hypoxia and sleep fragmentation, which seem to cause the systemic inflammatory response resulting in these end-organ consequences.
  • [MeSH-major] Sleep Apnea Syndromes / complications

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  • [Copyright] Copyright © 2010 Elsevier España S.L. All rights reserved.
  • (PMID = 21354490.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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39. |||....... 31%  Huang Y, Liu YH: Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity. Eur J Oral Sci; 2011 Apr;119(2):128-35
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  • [Title] Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity.
  • Chronic intermittent hypoxia (CIH) is a frequent feature of obstructive sleep apnea/hypopnea syndrome (OSAHS), and it may alter upper airway muscle endurance.
  • We conclude that phytoestrogens, especially genistein, could improve the endurance of the genioglossus muscle in ovariectomized rats exposed to CIH, and this effect is, in part, not related to its estrogenic action.
  • [MeSH-major] Coumestrol / pharmacology. Genistein / pharmacology. Muscle Contraction / drug effects. Muscle, Skeletal / drug effects. Phytoestrogens / pharmacology. Sleep Apnea, Obstructive / metabolism

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  • [Copyright] © 2011 Eur J Oral Sci.
  • (PMID = 21410552.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Phytoestrogens; 0 / RNA, Messenger; 0 / Receptors, Estrogen; DH2M523P0H / Genistein; V7NW98OB34 / Coumestrol
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40. |||....... 31%  Takenouchi T, Rubens EO, Yap VL, Ross G, Engel M, Perlman JM: Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy. J Pediatr; 2011 Aug;159(2):232-7
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  • [Title] Delayed onset of sleep-wake cycling with favorable outcome in hypothermic-treated neonates with encephalopathy.
  • OBJECTIVE: To determine whether hypothermia modulates acquisition of sleep-wake cycling in term neonates with moderate to severe hypoxic-ischemic encephalopathy (HIE) and the relationship to outcome.
  • Electroencephalograpic data were analyzed for background and sleep-wake cycling.
  • RESULTS: Acquisition of sleep-wake cycling was noted in nine infants by 72 hours, in 13 by 96 hours, 19 by 120 hours, and 22 by 144 hours.
  • Presence of sleep-wake cycling was associated with normal outcome, that is, 14 of 22 (64%), versus abnormal outcome, that is, none of seven without sleep-wake cycling (P = .006).
  • The presence of sleep-wake cycling by 120 hours had a positive predictive value of 68% and negative predictive value of 90%.
  • Magnetic resonance imaging abnormalities were related to onset of sleep-wake cycling.
  • CONCLUSIONS: Although onset of sleep-wake cycling is markedly delayed in term neonates with moderate to severe HIE treated with hypothermia, approximately 65% with acquisition of cycling have a normal outcome.
  • Sleep-wake cycling is an important additional tool for assessing recovery in term infants with moderate to severe HIE treated with hypothermia.
  • [MeSH-major] Brain / physiopathology. Circadian Rhythm / physiology. Hypothermia, Induced / methods. Hypoxia-Ischemia, Brain / therapy. Sleep / physiology

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  • [Copyright] Copyright © 2011 Mosby, Inc. All rights reserved.
  • (PMID = 21353680.001).
  • [ISSN] 1097-6833
  • [Journal-full-title] The Journal of pediatrics
  • [ISO-abbreviation] J. Pediatr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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41. |||....... 31%  Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E: Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation. Life Sci; 2009 Aug 26;85(9-10):372-8
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  • [Title] Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation.
  • AIMS: Obstructive sleep apnea syndrome (OSAS), characterized by intermittent hypoxia/reoxygenation (IHR), is often associated with changing levels of circulating inflammatory cytokines and causes excessive daytime sleepiness, mood disturbances, and cardiovascular disease.
  • An abnormal rhythm in the expression of circadian clock genes is observed in OSAS patients, and is also implicated in OSAS-related clinical symptoms.

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  • (PMID = 19616563.001).
  • [ISSN] 1879-0631
  • [Journal-full-title] Life sciences
  • [ISO-abbreviation] Life Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Interleukin-6; 0 / RNA, Messenger; 0 / Vascular Endothelial Growth Factor A
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42. |||....... 31%  Hunt NJ, Waters KA, Machaalani R: Orexin receptors in the developing piglet hypothalamus, and effects of nicotine and intermittent hypercapnic hypoxia exposures. Brain Res; 2013 May 1;1508:73-82
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  • [Title] Orexin receptors in the developing piglet hypothalamus, and effects of nicotine and intermittent hypercapnic hypoxia exposures.
  • Orexin and its receptors (OxR1 and OxR2) play a significant role in arousal and sleep regulation.
  • Using developing piglets, we aimed to determine the effects of nicotine and Intermittent Hypercapnic Hypoxia (IHH), alone or in combination, on orexin receptor expression in the hypothalamus.
  • IHH induced increases were specific to arousal and stress related regions and nic+IHH results suggest that for OxR1, nicotine has no additive effect whereas for OxR2 it does, and is region dependent.
  • [MeSH-minor] Animals. Arousal / physiology. Female. Humans. Immunohistochemistry. Infant, Newborn. Male. Orexin Receptors. Prone Position. Sex Characteristics. Sleep / physiology. Sleep Apnea, Obstructive / pathology. Sudden Infant Death. Swine

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23500635.001).
  • [ISSN] 1872-6240
  • [Journal-full-title] Brain research
  • [ISO-abbreviation] Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Nicotinic Agonists; 0 / Orexin Receptors; 0 / Receptors, G-Protein-Coupled; 0 / Receptors, Neuropeptide; 54-11-5 / Nicotine
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43. |||....... 31%  Bertuglia S, Reiter RJ: Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J Pineal Res; 2009 Apr;46(3):307-13
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  • [Title] Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
  • Obstructive sleep apnea (OSA) causes intermittent hypoxia (IH) associated with hypertension, insulin resistance and a systemic inflammatory response.
  • In conclusion, protection induced by melatonin against functional and metabolic impairment in IH is related to the regulation of ROS and nitrite/nitrate levels in the microcirculation.
  • [MeSH-minor] Analysis of Variance. Animals. Blood Glucose / drug effects. Cricetinae. Glucose Clamp Technique. Hemodynamics / drug effects. Hypertension / metabolism. Insulin / metabolism. Male. Mesocricetus. Nitrates / metabolism. Nitrites / metabolism. Reactive Oxygen Species / metabolism. Sleep Apnea, Obstructive. Statistics, Nonparametric

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  • (PMID = 19317794.001).
  • [ISSN] 1600-079X
  • [Journal-full-title] Journal of pineal research
  • [ISO-abbreviation] J. Pineal Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Blood Glucose; 0 / Insulin; 0 / Nitrates; 0 / Nitrites; 0 / Reactive Oxygen Species; JL5DK93RCL / Melatonin
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44. |||....... 30%  Minville C, Hilleret MN, Tamisier R, Aron-Wisnewsky J, Clement K, Trocme C, Borel JC, Lévy P, Zarski JP, Pépin JL: Nonalcoholic Fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea. Chest; 2014 Mar 1;145(3):525-33
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  • [Title] Nonalcoholic Fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
  • BACKGROUND: Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor for nonalcoholic fatty liver disease (NAFLD).
  • NAFLD severity and its implication in OSA-related endothelial dysfunction have not been investigated in a large, unselected OSA population, including nonobese subjects.
  • The dose-response relationship between the severity of nocturnal hypoxia and liver injury was established only in morbid obesity and not in lean.
  • CONCLUSIONS: In a large, unselected OSA population, the severity of nocturnal hypoxia was independently associated with steatosis.

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  • (PMID = 24264333.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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45. |||....... 30%  Verratti V, Falone S, Fanò G, Paoli A, Reggiani C, Tenaglia R, Di Giulio C: Effects of hypoxia on nocturnal erection quality: a case report from the Manaslu expedition. J Sex Med; 2011 Aug;8(8):2386-90
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  • [Title] Effects of hypoxia on nocturnal erection quality: a case report from the Manaslu expedition.
  • INTRODUCTION: High altitude environment represents a fine model to study physiological and pathophysiological effects of oxygen availability on sleep-related erections (SREs).
  • AIM: To describe altitude-dependent effects on quality of SREs in order to estimate the role of hypoxia in erection physiology.
  • METHODS: A healthy 37-year-old male mountain climber underwent a chronic high altitude-related hypoxia experience during the 43 days of the Manaslu expedition (Nepal).
  • The erection-related parameters assessed were: number, duration, event duration (% of session), event rigidity %, time rigidity %, tumescence and rigidity activated unit, and event tum % > bline (%).
  • RESULTS: Erectile parameters showed an altitude-related reduction during the hypoxic exposure, although all functional alterations were reverted by the return to sea level.
  • CONCLUSIONS: Our case report supports the hypothesis that oxygen availability and delivery could play an important role in the regulation of local penile erection-related mechanisms and that low oxygen levels might be considered an etiological cofactor in erectile dysfunction.

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  • [Copyright] © 2011 International Society for Sexual Medicine.
  • (PMID = 21595841.001).
  • [ISSN] 1743-6109
  • [Journal-full-title] The journal of sexual medicine
  • [ISO-abbreviation] J Sex Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. |||....... 30%  Dematteis M, Godin-Ribuot D, Arnaud C, Ribuot C, Stanke-Labesque F, Pépin JL, Lévy P: Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease. ILAR J; 2009;50(3):262-81
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  • [Title] Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease.
  • Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep fragmentation, and obstructed respiratory efforts.
  • The complexity of the disease and the reduced possibilities for patient investigations, especially at the tissue level, have limited progress in the understanding of sleep apnea pathophysiology and in the development of specific treatments.
  • Such studies have revealed some of the pathophysiological mechanisms and enabled the recognition of IH as the most important sleep apnea component underlying cardiovascular complications.
  • We review different animal models used to assess detrimental sleep apnea-related cardiovascular consequences: blood pressure elevation, impaired vasoreactivity, structural arterial remodeling leading to atherosclerosis, cardiac remodeling, and myocardial infarction.
  • By combining clinical and experimental research, these models will contribute to the understanding of differential patient susceptibility and to the elaboration of prevention strategies and tailored treatments for sleep apnea patients.
  • [MeSH-major] Cardiovascular Diseases / etiology. Disease Models, Animal. Sleep Apnea Syndromes / complications

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  • (PMID = 19506313.001).
  • [ISSN] 1930-6180
  • [Journal-full-title] ILAR journal / National Research Council, Institute of Laboratory Animal Resources
  • [ISO-abbreviation] ILAR J
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 242
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47. |||....... 30%  Nemeth D, Csábi E, Janacsek K, Várszegi M, Mari Z: Intact implicit probabilistic sequence learning in obstructive sleep apnea. J Sleep Res; 2012 Aug;21(4):396-401
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intact implicit probabilistic sequence learning in obstructive sleep apnea.
  • Obstructive sleep apnea (OSA) belongs to the sleep-related breathing disorders and is associated with cognitive impairments in learning and memory functions.
  • Surprisingly, OSA patients showed preserved general skill and sequence-specific learning in spite of the possible hypoxia and sleep restriction.
  • Our findings draw attention the fact that disordered sleep may have less impact on the integrity of structures connected to implicit sequence learning.
  • [MeSH-major] Serial Learning. Sleep Apnea, Obstructive / psychology

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  • [Copyright] © 2011 European Sleep Research Society.
  • (PMID = 22340304.001).
  • [ISSN] 1365-2869
  • [Journal-full-title] Journal of sleep research
  • [ISO-abbreviation] J Sleep Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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48. |||....... 30%  Mehra R, Stone KL, Varosy PD, Hoffman AR, Marcus GM, Blackwell T, Ibrahim OA, Salem R, Redline S: Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study. Arch Intern Med; 2009 Jun 22;169(12):1147-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study.
  • We studied the association between sleep-disordered breathing (SDB) with nocturnal atrial fibrillation or flutter (AF) and complex ventricular ectopy (CVE) in older men.
  • METHODS: A total of 2911 participants in the Outcomes of Sleep Disorders in Older Men Study underwent unattended polysomnography.
  • Exposures were (1) SDB defined by respiratory disturbance index (RDI) quartile (a major index including all apneas and hypopneas), and ancillary definitions incorporating (2) obstructive events, obstructive sleep apnea (OSA; Obstructive Apnea Hypopnea Index quartile), or (3) central events, central sleep apnea (CSA; Central Apnea Index category), and (4) hypoxia (percentage of sleep time with <90% arterial oxygen percent saturation).
  • Central sleep apnea was more strongly associated with AF (OR, 2.69; 95% CI, 1.61-4.47) than CVE (OR, 1.27; 95% CI, 0.97-1.66).
  • Hypoxia level was associated with CVE (P value for trend, <.001); those in the highest hypoxia category had an increased odds of CVE (OR, 1.62; 95% CI, 1.23-2.14) compared with the lowest quartile.
  • When SDB was characterized according to central or obstructive subtypes, CVE was associated most strongly with OSA and hypoxia, whereas AF was most strongly associated with CSA, suggesting that different sleep-related stresses may contribute to atrial and ventricular arrhythmogenesis in older men.
  • [MeSH-major] Arrhythmias, Cardiac / physiopathology. Circadian Rhythm / physiology. Heart Rate / physiology. Sleep Disorders / complications

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  • (PMID = 19546416.001).
  • [ISSN] 1538-3679
  • [Journal-full-title] Archives of internal medicine
  • [ISO-abbreviation] Arch. Intern. Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / K23 HL079114; United States / NHLBI NIH HHS / HL / K23 HL079114-01A2; United States / NHLBI NIH HHS / HL / R01 HL070837-05; United States / NHLBI NIH HHS / HL / R01 HL070838; United States / NHLBI NIH HHS / HL / R01 HL070838; United States / NHLBI NIH HHS / HL / R01 HL070838-05; United States / NHLBI NIH HHS / HL / R01 HL070839; United States / NHLBI NIH HHS / HL / R01 HL070839-05; United States / NHLBI NIH HHS / HL / R01 HL070841; United States / NHLBI NIH HHS / HL / R01 HL070841-05; United States / NHLBI NIH HHS / HL / R01 HL070842; United States / NHLBI NIH HHS / HL / R01 HL070842-05; United States / NHLBI NIH HHS / HL / R01 HL070847; United States / NHLBI NIH HHS / HL / R01 HL070847; United States / NHLBI NIH HHS / HL / R01 HL070847-05; United States / NHLBI NIH HHS / HL / R01 HL070848; United States / NHLBI NIH HHS / HL / R01 HL070848-05; United States / NHLBI NIH HHS / HL / R01 HL071194; United States / NHLBI NIH HHS / HL / R01 HL071194-07; United States / NHLBI NIH HHS / HL / R01HL070837; United States / NIA NIH HHS / AG / U01 AG018197-11; United States / NIA NIH HHS / AG / U01 AG027810; United States / NIA NIH HHS / AG / U01 AG027810-04; United States / NIA NIH HHS / AG / U01 AG18197; United States / NIAMS NIH HHS / AR / U01 AR045580-07; United States / NIAMS NIH HHS / AR / U01 AR045583-07; United States / NIAMS NIH HHS / AR / U01 AR045614; United States / NIAMS NIH HHS / AR / U01 AR045614-07; United States / NIAMS NIH HHS / AR / U01 AR045632-07; United States / NIAMS NIH HHS / AR / U01 AR045647; United States / NIAMS NIH HHS / AR / U01 AR045647-07; United States / NIAMS NIH HHS / AR / U01 AR045654-07; United States / NIAMS NIH HHS / AR / U01 AR45580; United States / NIAMS NIH HHS / AR / U01 AR45583; United States / NIAMS NIH HHS / AR / U01 AR45632; United States / NIAMS NIH HHS / AR / U01 AR45647; United States / NIAMS NIH HHS / AR / U01 AR45654; United States / NIA NIH HHS / AG / U01-AG027810; United States / NIAMS NIH HHS / AR / U01AR45614; United States / NCRR NIH HHS / RR / UL1 RR024140; United States / NCRR NIH HHS / RR / UL1 RR024140-04; United States / NCRR NIH HHS / RR / UL1RR024140
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS160781; NLM/ PMC2802061
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49. |||....... 30%  Nussbaumer-Ochsner Y, Ursprung J, Siebenmann C, Maggiorini M, Bloch KE: Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing. Sleep; 2012 Mar;35(3):419-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing.
  • STUDY OBJECTIVE: Objective physiologic data on sleep and nocturnal breathing at initial exposure and during acclimatization to high altitude are scant.
  • We tested the hypothesis that acute exposure to high altitude induces quantitative and qualitative changes in sleep and that these changes are partially reversed with acclimatization.
  • SETTING: One night in a sleep laboratory at 490 meters, the first and the third night in a mountain hut at 4559 meters.
  • MEASUREMENTS: Polysomnography, questionnaire evaluation of sleep and acute mountain sickness.
  • RESULTS: Compared to 490 m, median nocturnal oxygen saturation decreased during the 1st night at 4559 m from 96% to 67%, minute ventilation increased from 4.4 to 6.3 L/min, and the apnea-hypopnea index increased from 0.1 to 60.9/h; correspondingly, sleep efficiency decreased from 93% to 69%, and slow wave sleep from 18% to 6% (P < 0.05, all instances).
  • During the 3rd night at 4559 m, oxygen saturation was 71%, slow wave sleep 11% (P < 0.05 vs. 1st night, both instances) and the apnea/hypopnea index was 86.5/h (P = NS vs. 1st night).
  • Symptoms of AMS and of disturbed sleep were significantly reduced in the morning after the 3rd vs. the 1st night at 4559 m.
  • CONCLUSIONS: In healthy mountaineers ascending rapidly to high altitude, sleep quality is initially impaired but improves with acclimatization in association with improved oxygen saturation, while periodic breathing persists.
  • Therefore, high altitude sleep disturbances seem to be related predominantly to hypoxemia rather than to periodic breathing.
  • [MeSH-major] Acclimatization / physiology. Altitude. Circadian Rhythm / physiology. Mountaineering / physiology. Respiration. Sleep / physiology

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  • (PMID = 22379248.001).
  • [ISSN] 1550-9109
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3274343
  • [Keywords] NOTNLM ; Altitude / apnea / hypoxia / sleep / ventilation
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50. |||....... 30%  Perry JC, Guindalini C, Bittencourt L, Garbuio S, Mazzotti DR, Tufik S: Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans. Respir Physiol Neurobiol; 2013 Dec 1;189(3):649-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans.
  • In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA).
  • Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups.

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23994550.001).
  • [ISSN] 1878-1519
  • [Journal-full-title] Respiratory physiology & neurobiology
  • [ISO-abbreviation] Respir Physiol Neurobiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; CPAP / Gene expression / Hypoxia / Obstructive sleep apnea / Sleep
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