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1. Biomedical articles (top 50; 2009 to 2014)
1. |||||..... 50%  Miyamura M, Schnell O, Yamashita C, Yoshioka T, Matsumoto C, Mori T, Ukimura A, Kitaura Y, Matsumura Y, Ishizaka N, Hayashi T: Effects of acarbose on the acceleration of postprandial hyperglycemia-induced pathological changes induced by intermittent hypoxia in lean mice. J Pharmacol Sci; 2010;114(1):32-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of acarbose on the acceleration of postprandial hyperglycemia-induced pathological changes induced by intermittent hypoxia in lean mice.
  • Postprandial hyperglycemia (PPH) and intermittent hypoxia related to the sleep apnea syndrome are important predictors of cardiovascular disease.
  • We investigated the effects of intermittent hypoxia on pathological changes in the left ventricular (LV) myocardium caused by PPH in lean mice and evaluated the influence of acarbose, an α-glucosidase inhibitor.
  • Male C57BL/6J mice aged 8 weeks were exposed to intermittent hypoxia (8 h/day during the daytime) or kept under normoxia.
  • Intermittent hypoxia exacerbated cardiomyocyte hypertrophy and interstitial fibrosis in the LV myocardium of RD mice.
  • Superoxide production and expression of 4-hydroxy-2-nonenal in the LV myocardium with intermittent hypoxia were increased in RD mice, but not AL mice.

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  • (PMID = 20703014.001).
  • [ISSN] 1347-8648
  • [Journal-full-title] Journal of pharmacological sciences
  • [ISO-abbreviation] J. Pharmacol. Sci.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] T58MSI464G / Acarbose
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2. ||||...... 44%  Feng J, Wu Q, Zhang D, Chen BY: Hippocampal impairments are associated with intermittent hypoxia of obstructive sleep apnea. Chin Med J (Engl); 2012 Feb;125(4):696-701
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hippocampal impairments are associated with intermittent hypoxia of obstructive sleep apnea.
  • Obstructive sleep apnea (OSA), which is the most common sleep-related breathing disorder, is characterized as frequent upper airway collapse and obstruction.
  • In studies of OSA, it is difficult to differentiate the effects of its two main pathologic traits, intermittent hypoxia (IH) and sleep fragmentation.
  • IH, continuous hypoxia and intermittent continuous hypoxia can all result in decreases in arterial O2.
  • [MeSH-major] Anoxia / physiopathology. Hippocampus / physiopathology. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 22490498.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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3. ||||...... 40%  Feng J, Chiang AA, Wu Q, Chen BY, Cui LY, Liang DC, Zhang ZL, Yao W: Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats. Chin Med J (Engl); 2010 Sep;123(17):2392-9
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  • [Title] Sleep-related hypoxemia aggravates systematic inflammation in emphysematous rats.
  • BACKGROUND: Sleep disturbance is common in patients with emphysema.
  • This study aimed to develop a novel model of sleep-related hypoxemia (SRH) in emphysema (SRHIE) with rats, and to explore the inflammatory status of SRHIE in lung, liver, pancreas, carotid artery and whole blood.
  • The protocols varied with the degree of hypoxia exposure and severity of pre-existing emphysema caused by cigarette smoke exposure:.
  • (1) SRH control (SRHCtrl) group, sham smoke exposure (smoke exposure, exposed to smoke of 15 cigarettes twice everyday, 16 weeks) and SRH exposure (12.5% O2, 3 hours, SRH exposure, divide total hypoxia time (1.5 hours or 3 hours) into 4 periods evenly (22.5 minutes or 45 minutes) and distribute these hypoxia periods evenly into physiological sleep time of rats identified by electroencephalogram, week 9 to week 16);.
  • [MeSH-major] Anoxia / complications. Emphysema / complications. Inflammation / etiology. Sleep / physiology

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  • (PMID = 21034555.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Hemoglobins
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4. ||||...... 40%  Beuchée A, Hernández AI, Duvareille C, Daniel D, Samson N, Pladys P, Praud JP: Influence of hypoxia and hypercapnia on sleep state-dependent heart rate variability behavior in newborn lambs. Sleep; 2012 Nov;35(11):1541-9
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  • [Title] Influence of hypoxia and hypercapnia on sleep state-dependent heart rate variability behavior in newborn lambs.
  • STUDY OBJECTIVES: Although hypercapnia and/or hypoxia are frequently present during chronic lung disease of infancy and have also been implicated in sudden infant death syndrome (SIDS), their effect on cardiac autonomic regulation remains unclear.
  • The authors' goal is to test that hypercapnia and hypoxia alter sleep-wake cycle-dependent heart rate variability (HRV) in the neonatal period.
  • DESIGN: Experimental study measuring HRV during sleep states in lambs randomly exposed to hypercapnia, hypoxia, or air.
  • INTERVENTIONS: Each lamb underwent polysomnographic recordings while in a chamber flowed with either air or 21% O(2) + 5% CO(2) (hypercapnia) or 10% O(2) + 0% CO(2) (hypoxia) on day 3, 4, and 5 of postnatal age.
  • MEASUREMENTS AND RESULTS: Hypercapnia increased the time spent in wakefulness and hypoxia the time spent in quiet sleep (QS).
  • Compared with QS, active sleep (AS) was associated with an overall increase in HRV magnitude and short-term self-similarity and a decrease in entropy of cardiac cycle length in air.
  • This AS-related HRV pattern persisted in hypercapnia and was even more pronounced in hypoxia.
  • CONCLUSION: Enhancement of AS-related sympathovagal coactivation in hypoxia, together with increased heart rate regularity, may be evidence that AS + hypoxia represent a particularly vulnerable state in early life.
  • This should be kept in mind when deciding the optimal arterial oxygenation target in newborns and when investigating the potential involvement of hypoxia in SIDS pathogenesis.
  • [MeSH-major] Anoxia / physiopathology. Heart Rate. Hypercapnia / physiopathology. Sleep

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  • (PMID = 23115403.001).
  • [ISSN] 1550-9109
  • [Journal-full-title] Sleep
  • [ISO-abbreviation] Sleep
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / / MOP 15558
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3466801
  • [Keywords] NOTNLM ; Entropy / REM sleep / frequency domain analysis / quiet sleep / scale-invariance / sympathovagal coactivation
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5. |||....... 25%  Cooper IF, Siadaty MS: 'Diseases or Syndromes' associated with 'Respiratory Hypoxia': Top Publications. BioMedLib Review; DiseaseOrSyndrome;RespiratoryHypoxia:705309855. ISSN: 2331-5717. 2014/8/31
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  • [Title] 'Diseases or Syndromes' associated with 'Respiratory Hypoxia': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Disease or Syndrome' for 'respiratory hypoxia'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Disease or Syndrome'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 21 publications, and group two 5838 publications.
  • Here are the top 10.
  • Lüneburg N et al: The endothelial ADMA/NO pathway in hypoxia-related chronic respiratory diseases.
  • Mahamed S et al: Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?.
  • Tafil-Klawe M et al: Reflex respiratory responses to progressive hyperoxic hypercapnia and normocapnic hypoxia in normocapnic and hypercapnic obstructive sleep apnea patients.
  • Thylefors J et al: Dark adaptation during systemic hypoxia induced by chronic respiratory insufficiency.
  • Ecevit A et al: Association of respiratory distress syndrome and perinatal hypoxia with histologic chorioamnionitis in preterm infants.
  • Höhne C et al: Low sodium intake does not impair renal compensation of hypoxia-induced respiratory alkalosis.
  • Han F et al: [Respiratory control during sleep and the development of nocturnal hypoxia in patients with obstructive sleep apnea hypopnea syndrome].
  • de Theije C et al: Hypoxia and muscle maintenance regulation: implications for chronic respiratory disease.
  • Mel'nikova IP et al: [Intermittent normobaric hypoxia in rehabilitation of young seamen with respiratory diseases].
  • Bernardi L et al: Respiratory and cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 705309855.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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6. ||||...... 37%  Nakagawa Y, Kishida K, Kihara S, Yoshida R, Funahashi T, Shimomura I: Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. J Atheroscler Thromb; 2011;18(3):240-7
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  • [Title] Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue.
  • AIM: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with atherosclerotic cardio-vascular disease.
  • Venous blood samples were collected before sleep and after waking up.
  • We investigated the effect of hypoxia on adiponectin expression in mesenteric and subcutaneous fat tissues of obese yellow-KKAy mice.
  • In obese yellow-KKAy mice, exposure to hypoxia for 2 days suppressed plasma adiponectin levels, with no apparent change in mesenteric and subcutaneous fat tissue adiponectin mRNA expression.
  • CONCLUSIONS: These findings suggest that abdominal obesity, representing abundant mesenteric fat tissue susceptible to hypoxic stress, partly explains Δadiponectin in OSAS patients, and that reduction of visceral fat accumulation may combat OSAS-related atherosclerotic cardiovascular diseases in abdominal obesity.
  • [MeSH-major] Adiponectin / metabolism. Adipose Tissue / metabolism. Anoxia. Circadian Rhythm / physiology. Mesentery / metabolism. Sleep Apnea, Obstructive / metabolism

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  • (PMID = 21139317.001).
  • [ISSN] 1880-3873
  • [Journal-full-title] Journal of atherosclerosis and thrombosis
  • [ISO-abbreviation] J. Atheroscler. Thromb.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Adiponectin
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7. ||||...... 37%  Türkay C, Ozol D, Kasapoğlu B, Kirbas I, Yıldırım Z, Yiğitoğlu R: Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia. Respir Care; 2012 Feb;57(2):244-9
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  • [Title] Influence of obstructive sleep apnea on fatty liver disease: role of chronic intermittent hypoxia.
  • BACKGROUND: Currently the common pathogenetic mechanisms in nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) are gaining increased attention.
  • The aim of this study is to find out the influence of chronic intermittent hypoxemia and OSA related parameters to the severity of NAFLD.
  • Our multivariate analysis showed that AHI, oxygen desaturation index, lowest desaturation values, and percentage of sleep duration with S(pO(2)) < 90% were independent predictors of NAFLD after adjustment for BMI, weight, and insulin resistance.
  • Furthermore, the most correlated parameter for the severity of NAFLD was found as the duration of hypoxia during sleep.
  • [MeSH-major] Anoxia. Fatty Liver. Oxygen / analysis. Sleep Apnea, Obstructive

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  • (PMID = 21762556.001).
  • [ISSN] 0020-1324
  • [Journal-full-title] Respiratory care
  • [ISO-abbreviation] Respir Care
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] S88TT14065 / Oxygen; Non-alcoholic Fatty Liver Disease
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8. ||||...... 38%  Lombardi C, Meriggi P, Agostoni P, Faini A, Bilo G, Revera M, Caldara G, Di Rienzo M, Castiglioni P, Maurizio B, Gregorini F, Mancia G, Parati G, HIGHCARE Investigators: High-altitude hypoxia and periodic breathing during sleep: gender-related differences. J Sleep Res; 2013 Jun;22(3):322-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-altitude hypoxia and periodic breathing during sleep: gender-related differences.
  • High-altitude exposure is characterized by the appearance of periodic breathing during sleep.
  • Only limited evidence is available, however, on the presence of gender-related differences in this breathing pattern.
  • Females started to present a significant number of central sleep apneas only at the highest reached altitude.
  • [MeSH-major] Anoxia / complications. Monitoring, Ambulatory / instrumentation. Sleep / physiology. Sleep Apnea, Central / physiopathology

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  • [Copyright] © 2013 European Sleep Research Society.
  • (PMID = 23294420.001).
  • [ISSN] 1365-2869
  • [Journal-full-title] Journal of sleep research
  • [ISO-abbreviation] J Sleep Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Benzimidazoles; 0 / Benzoates; 0 / Placebos; S88TT14065 / Oxygen; U5SYW473RQ / telmisartan
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9. ||........ 21%  Cooper IF, Siadaty MS: 'Spatial Concepts' associated with 'Disturbance In Sleep Behavior': Top Publications. BioMedLib Review; SpatialConcept;DisturbanceInSleep:707395026. ISSN: 2331-5717. 2014/7/9
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  • [Title] 'Spatial Concepts' associated with 'Disturbance In Sleep Behavior': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'Spatial Concept' for 'disturbance in sleep behavior'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals, and there are many types of 'Spatial Concept'.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 40 publications, and group two 8499 publications.
  • Here are the top 10.
  • Jones CR: Diagnostic and management approach to common sleep disorders during pregnancy.
  • Iacono Isidoro S et al: Quality of life in patients at first time visit for sleep disorders of breathing at a sleep centre.
  • Suzuki T et al: [The efficacy of imidafenacin in patients with over active bladder, nocturia, or sleep disorders (Sayama-Iruma-Hannou study)].
  • Rener-Sitar K et al: Exploration of dimensionality and psychometric properties of the Pittsburgh Sleep Quality Index in cases with temporomandibular disorders.
  • Sharma PK et al: Primary sleep disorders seen at a Neurology service-based sleep clinic in India: Patterns over an 8-year period.
  • Babson KA et al: The comorbidity of sleep apnea and mood, anxiety, and substance use disorders among obese military veterans within the Veterans Health Administration.
  • Johannessen B: Nurses experience of aromatherapy use with dementia patients experiencing disturbed sleep patterns. An action research project.
  • Jernelöv S et al: Development of atopic disease and disturbed sleep in childhood and adolescence--a longitudinal population-based study.
  • Ritter PS et al: Disturbed sleep in bipolar disorder is related to an elevation of IL-6 in peripheral monocytes.
  • Passàli D et al: The undisclosed role of disturbed sleep and hypoxia on metabolism: the importance of upper airways pathology.

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  • [Copyright] Copyright 2014 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 707395026.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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10. |||||||||. 8744%  Jinnur P, Kumar N, Vassallo R, St Louis EK: A 54-year-old man with acute onset orthopnea and sleep-related hypoxia. J Clin Sleep Med; 2014 May 15;10(5):595-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 54-year-old man with acute onset orthopnea and sleep-related hypoxia.

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  • (PMID = 24812547.001).
  • [ISSN] 1550-9397
  • [Journal-full-title] Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • [ISO-abbreviation] J Clin Sleep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4013390 [Available on 11/15/14]
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11. |||||||||. 1053%  Kuhle S, Urschitz MS, Eitner S, Poets CF: Interventions for obstructive sleep apnea in children: a systematic review. Sleep Med Rev; 2009 Apr;13(2):123-31
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  • [Title] Interventions for obstructive sleep apnea in children: a systematic review.
  • BACKGROUND: Obstructive sleep apnea (OSA) is characterized by habitual snoring, heavy breathing, sleep-related hypoxia and arousals from sleep, and is found in approximately 3% of children.
  • [MeSH-major] Sleep Apnea, Obstructive / therapy

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  • (PMID = 19059794.001).
  • [ISSN] 1087-0792
  • [Journal-full-title] Sleep medicine reviews
  • [ISO-abbreviation] Sleep Med Rev
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 36
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12. |||||||||. 1022%  Shepard P, Lam EM, St Louis EK, Dominik J: Sleep disturbances in myotonic dystrophy type 2. Eur Neurol; 2012;68(6):377-80
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  • [Title] Sleep disturbances in myotonic dystrophy type 2.
  • Sleep disorders in myotonic dystrophy type 1 (DM1) are common and include sleep-disordered breathing, hypersomnia, and fatigue.
  • Little is known regarding the occurrence of sleep disturbance in myotonic dystrophy type 2 (DM2).
  • We hypothesized that DM2 patients may frequently harbor sleep disorders.
  • We reviewed medical records of all genetically confirmed cases of DM2 seen at our sleep center between 1997 and 2010 for demographic, laboratory, overnight oximetry, and polysomnography (PSG) data.
  • Obstructive sleep apnea was diagnosed in 3 of 5 patients (60%) studied with PSG.
  • The clinical spectrum of DM2 may include a wide range of sleep disturbances.
  • Although respiratory muscle weakness was frequent, sustained sleep-related hypoxia suggestive of hypoventilation was not seen in our patients.
  • Further prospective studies are needed to examine the frequency and scope of sleep disturbances in DM2.
  • [MeSH-major] Disorders of Excessive Somnolence / physiopathology. Myotonic Disorders / complications. Sleep Disorders / etiology

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  • [Copyright] Copyright © 2012 S. Karger AG, Basel.
  • (PMID = 23108384.001).
  • [ISSN] 1421-9913
  • [Journal-full-title] European neurology
  • [ISO-abbreviation] Eur. Neurol.
  • [Language] eng
  • [Grant] United States / NCATS NIH HHS / TR / UL1 TR000135
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Switzerland
  • [Chemical-registry-number] Dystrophia myotonica 2
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13. |||||..... 50%  Ucar ZZ, Taymaz Z, Erbaycu AE, Kirakli C, Tuksavul F, Guclu SZ: Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders. South Med J; 2009 Jul;102(7):693-700
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  • [Title] Nocturnal hypoxia and arterial lactate levels in sleep-related breathing disorders.
  • BACKGROUND: Lactate may be useful in pointing out the higher risk subgroups in sleep-related breathing disorders (SRBD) with various patterns of hypoxemia.
  • We aimed to search whether morning and night lactate levels are related to apnea-hypopnea, hypoventilation, and hypoxemia in patients with SRBD and to compare it with patients without SRBD (No-SRBD).
  • SRBD patients had obstructive sleep apnea syndrome with or without sleep-related hypoventilation/hypoxemic conditions.
  • After an adjustment for age, gender, and body mass index, lactate levels before PSG were related to the apnea-hypopnea index (beta: 0.004, 95% CI: 0.000-0.008) and the rate of sleep-time spent under 90% oxygen saturation (T90%).
  • CONCLUSION: As a marker of tissue hypoxia, arterial lactate may be used to assess the severity of SRBD.
  • [MeSH-major] Anoxia / blood. Lactic Acid / blood. Sleep Apnea, Obstructive / blood. Sleep Apnea, Obstructive / diagnosis

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  • (PMID = 19487994.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biological Markers; 33X04XA5AT / Lactic Acid
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14. |||||..... 49%  Inamoto S, Yoshioka T, Yamashita C, Miyamura M, Mori T, Ukimura A, Matsumoto C, Matsumura Y, Kitaura Y, Hayashi T: Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice. Hypertens Res; 2010 Jun;33(6):579-86
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  • [Title] Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice.
  • We have reported previously that intermittent hypoxia related to sleep apnea induces cardiovascular remodeling secondary to the oxidative stress.
  • The aim of this study was to examine the effect of pitavastatin as an antioxidant to prevent intermittent hypoxia-induced left ventricular (LV) remodeling in mice without hypercholesterolemia.
  • Eight-week-old male C57BL/6J mice (n=35) were exposed to intermittent hypoxia (30 s exposure to 5% oxygen, followed by 30 s exposure to 21% oxygen) for 8 h per day during the daytime or maintained under normoxic conditions; in addition, they were either treated with pitavastatin (3 mg kg(-1) per day) or vehicle for 10 days.
  • Intermittent hypoxia significantly increased the expression levels of 4-hydroxy-2-nonenal (4-HNE) proteins, TNF-alpha and TGF-beta mRNA, and also the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling (TUNEL)-positive myocardial cells in the LV myocardium.
  • Treatment with pitavastatin significantly suppressed the expression levels of the 4-HNE proteins, cytokines, superoxide production and TUNEL-positive myocardial cells in the LV myocardium, consequently attenuating the hypoxia-induced histological changes.
  • Pitavastatin preserved, at least partially, the morphological structure of the LV myocardium in lean mice exposed to intermittent hypoxia, through its antioxidant effect.
  • [MeSH-major] Anoxia / complications. Antioxidants / therapeutic use. Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use. Oxidative Stress / drug effects. Quinolines / therapeutic use. Sleep Apnea Syndromes / complications. Ventricular Remodeling / drug effects

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  • [CommentIn] Hypertens Res. 2010 Jun;33(6):535-6 [20448637.001]
  • (PMID = 20300107.001).
  • [ISSN] 1348-4214
  • [Journal-full-title] Hypertension research : official journal of the Japanese Society of Hypertension
  • [ISO-abbreviation] Hypertens. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Antioxidants; 0 / Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0 / Quinolines; 0 / Transforming Growth Factor beta; 0 / Tumor Necrosis Factor-alpha; 29343-52-0 / 4-hydroxy-2-nonenal; 97C5T2UQ7J / Cholesterol; M5681Q5F9P / pitavastatin
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15. |||||..... 48%  de Castro-Silva C, de Bruin VM, Cavalcante AG, Bittencourt LR, de Bruin PF: Nocturnal hypoxia and sleep disturbances in cystic fibrosis. Pediatr Pulmonol; 2009 Nov;44(11):1143-50
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  • [Title] Nocturnal hypoxia and sleep disturbances in cystic fibrosis.
  • Disrupted sleep and nocturnal hypoxia are common in cystic fibrosis (CF).
  • However, the predictors of nocturnal hypoxia in CF are still controversial.
  • In order to identify the risk factors for nocturnal desaturation and sleep disturbances, we carried out a clinical and polysomnographic investigation of CF patients.
  • During sleep, five CF cases with clinical lung disease (15%) had SaO(2) <90% during more than 30% of total sleep time and 11 cases (36.6%) had a nadir SaO(2) below 85%.
  • FEV1 values for CF cases with clinical lung disease were related to nadir SaO(2) (P < 0.03) and to mean SaO(2) (P = 0.02).
  • A receiver operating characteristic (ROC) analysis determined FEV1 at 64% to be predictive of nocturnal desaturation as defined by minimum SaO(2) <85% (sensitivity = 92.3%; specificity = 77.3%) or SaO(2) <90% for 30% of sleep time (sensitivity = 81.8%; specificity = 85.2%).
  • Frequency of impaired sleep was not different in CF cases with (N = 2) and without significant lung disease (N = 5, P = 0.53).
  • Sleep architecture was not significantly different between the two groups.
  • Sleep apnea was present in three CF cases with clinical lung disease and in one case without significant lung disease.
  • In summary, desaturation during sleep can be predicted by FEV1 <64% with good sensitivity and specificity.
  • There are no significant differences in sleep architecture between clinically stable CF cases with and without significant lung disease.
  • [MeSH-major] Anoxia / diagnosis. Anoxia / etiology. Cystic Fibrosis / complications. Sleep Apnea Syndromes / diagnosis. Sleep Apnea Syndromes / etiology


16. |||||..... 48%  Ramar K, Caples SM: Vascular changes, cardiovascular disease and obstructive sleep apnea. Future Cardiol; 2011 Mar;7(2):241-9
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  • [Title] Vascular changes, cardiovascular disease and obstructive sleep apnea.
  • Vascular changes related to obstructive sleep apnea (OSA) can lead to chronic cardiovascular consequences such as hypertension.
  • The cardiovascular consequences are owing to nocturnal perturbations related to intrathoracic pressure changes, intermittent hypoxia, sympathetic neural activation, endothelial dysfunction, oxidative stress and systemic inflammation.
  • Intermittent hypoxia due to sleep-related events in OSA activates the renin-angiotensin system and increases the levels of endothelin-1.
  • Intermittent hypoxia also results in oxidative stress, as evidenced by elevated levels of xanthine oxidoreductase, lipid peroxidation and the presence of reactive oxygen species.
  • [MeSH-major] Cardiovascular Diseases / etiology. Endothelium, Vascular / physiopathology. Sleep Apnea, Obstructive / complications. Vasodilation / physiology

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  • (PMID = 21453030.001).
  • [ISSN] 1744-8298
  • [Journal-full-title] Future cardiology
  • [ISO-abbreviation] Future Cardiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
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17. ||||...... 40%  Dergacheva O, Weigand LA, Dyavanapalli J, Mares J, Wang X, Mendelowitz D: Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea. Prog Brain Res; 2014;212:39-58
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  • [Title] Function and modulation of premotor brainstem parasympathetic cardiac neurons that control heart rate by hypoxia-, sleep-, and sleep-related diseases including obstructive sleep apnea.
  • Whereas prior reviews have focused on glutamatergic, GABAergic and glycinergic pathways, and the receptors in CVNs activated by these neurotransmitters, this review focuses on the alterations in CVN activity with hypoxia-, sleep-, and sleep-related cardiovascular diseases including obstructive sleep apnea.

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  • [Copyright] © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 25194192.001).
  • [ISSN] 1875-7855
  • [Journal-full-title] Progress in brain research
  • [ISO-abbreviation] Prog. Brain Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; REM / ambiguus / apnea / cardiac / non-REM / obstructive / parasympathetic / serotonin / sleep / vagal
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18. ||||...... 37%  Bell HJ, Ferguson C, Kehoe V, Haouzi P: Hypocapnia increases the prevalence of hypoxia-induced augmented breaths. Am J Physiol Regul Integr Comp Physiol; 2009 Feb;296(2):R334-44
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  • [Title] Hypocapnia increases the prevalence of hypoxia-induced augmented breaths.
  • Augmented breaths promote respiratory instability and have been implicated in triggering periods of sleep-disordered breathing.
  • Since respiratory instability is well known to be exacerbated by hypocapnia, we asked whether one of the destabilizing effects of hypocapnia might be related to an increased prevalence of augmented breaths.
  • With this question in mind, we first sought to determine whether hypoxia-induced augmented breaths are more prevalent when hypocapnia is also present.
  • We found that the prevalence of augmented breaths was dramatically increased during hypocapnic-hypoxia compared with room air conditions.
  • When hypocapnia was prevented during exposure to hypoxia by adding 5% CO2 to the inspired air, the rate of occurrence of augmented breaths was no greater than that observed in room air.
  • We conclude that in spontaneously breathing rats, hypoxia promotes the generation of augmented breaths, but only in poikilocapnic conditions, where hypocapnia develops.
  • Our results, therefore, reveal a means by which CO2 exerts a stabilizing influence on breathing, which may be of particular relevance during sleep in conditions commonly associated with respiratory instability.

  • HSDB. structure - CARBON DIOXIDE.
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  • (PMID = 19091914.001).
  • [ISSN] 0363-6119
  • [Journal-full-title] American journal of physiology. Regulatory, integrative and comparative physiology
  • [ISO-abbreviation] Am. J. Physiol. Regul. Integr. Comp. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 142M471B3J / Carbon Dioxide; S88TT14065 / Oxygen
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19. ||||...... 37%  Giusi G, Zizza M, Facciolo RM, Chew SF, Ip YK, Canonaco M: Aestivation and hypoxia-related events share common silent neuron trafficking processes. BMC Neurosci; 2012;13:39
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  • [Title] Aestivation and hypoxia-related events share common silent neuron trafficking processes.
  • BACKGROUND: The availability of oxygen is a limiting factor for neuronal survival since low levels account not only for the impairment of physiological activities such as sleep-wake cycle, but above all for ischemic-like neurodegenerative disorders.
  • This functional relationship might have therapeutic bearings for hypoxia-related dysfunctions, above all in view of recently identified silent neuron-dependent motor activity ameliorations in mammals.
  • [MeSH-major] Anoxia. Estivation / physiology. Gene Expression Regulation / physiology. Hypoxia-Inducible Factor 1, alpha Subunit / metabolism. Neurons / metabolism

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  • (PMID = 22520032.001).
  • [ISSN] 1471-2202
  • [Journal-full-title] BMC neuroscience
  • [ISO-abbreviation] BMC Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / HSP72 Heat-Shock Proteins; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / RNA, Messenger; 0 / Receptors, AMPA; 0 / glutamate receptor ionotropic, AMPA 1; 0 / glutamate receptor ionotropic, AMPA 2
  • [Other-IDs] NLM/ PMC3407487
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20. ||||...... 37%  Lavie L, Polotsky V: Cardiovascular aspects in obstructive sleep apnea syndrome--molecular issues, hypoxia and cytokine profiles. Respiration; 2009;78(4):361-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cardiovascular aspects in obstructive sleep apnea syndrome--molecular issues, hypoxia and cytokine profiles.
  • Obstructive sleep apnea syndrome (OSAS), which is a highly prevalent breathing disorder in sleep, is an independent risk factor for cardiovascular morbidity and mortality.
  • Results from clinical studies as well as animal models and cell culture studies utilizing intermittent hypoxia implicate oxidative stress and inflammation in the pathogenesis of OSAS.
  • The current review highlights some of the recent findings on oxidative stress and inflammation in OSAS with specific emphasis on the role of inflammatory pathway activation and expression of cytokines and their possible role in OSAS-related cardiovascular morbidity.
  • [MeSH-major] Cardiovascular Diseases / etiology. Cytokines / metabolism. Oxidative Stress. Sleep Apnea, Obstructive / complications. Sleep Apnea, Obstructive / metabolism

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  • [Copyright] Copyright © 2009 S. Karger AG, Basel.
  • (PMID = 19786735.001).
  • [ISSN] 1423-0356
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL080105; United States / NHLBI NIH HHS / HL / R01 HL080105-05A1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Cytokines; 0 / Transcription Factors
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21. ||||...... 36%  Hoshikawa M, Uchida S, Ganeko M, Sumitomo J, Totoki M, Kojima T, Nakamura Y, Kawahara T: Sleep quality under mild hypoxia in men with low hypoxic ventilatory response. Eur J Sport Sci; 2014;14 Suppl 1:S205-12
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  • [Title] Sleep quality under mild hypoxia in men with low hypoxic ventilatory response.
  • The present study evaluated whether slow-wave sleep and whole-night delta power of the non-rapid eye movement (NREM) sleep electroencephalogram (EEG) decrease during sleep at a simulated altitude of 2000 m, and whether such changes related to measures of hypoxic ventilatory response (HVR).
  • This study consisted of two parts; in the first, HVR was measured in 41 subjects and each seven subjects with the lowest or the highest HVR were selected for the subsequent sleep study.
  • Hypoxia decreased SpO2 and increased respiratory disturbances for both groups.
  • The low HVR group, but not the high HVR group, showed decreases in the whole-night delta power of NREM sleep EEG under hypoxia.
  • On the other hand, two subjects in the high HVR group, who showed relatively high apnoea indices, also showed lower SpO2 nadirs and decreases in the whole-night delta power under hypoxia.
  • These results suggest that acute hypoxia equivalent to that at a 2000 m altitude decreases slow-wave sleep in individuals that show low HVR.
  • However, low HVR may not be the only, but one of some factors that decrease the whole-night delta power under hypoxia.
  • Therefore, it was not sufficient to identify individuals likely to be susceptible to deteriorated sleep quality at a simulated altitude of 2000 m only using the HVR test.
  • [MeSH-major] Anoxia / physiopathology. Oxygen Consumption / physiology. Sleep / physiology

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  • (PMID = 24444208.001).
  • [ISSN] 1536-7290
  • [Journal-full-title] European journal of sport science
  • [ISO-abbreviation] Eur J Sport Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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22. ||||...... 35%  Kubin L: Sleep-wake control of the upper airway by noradrenergic neurons, with and without intermittent hypoxia. Prog Brain Res; 2014;209:255-74
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  • [Title] Sleep-wake control of the upper airway by noradrenergic neurons, with and without intermittent hypoxia.
  • Hypoglossal (XII) motoneurons innervate muscles of the tongue whose tonic and inspiratory modulated activity protects the upper airway from collapse in patients affected by the obstructive sleep apnea (OSA) syndrome.
  • Both norepinephrine and serotonin provide wakefulness-related excitatory drives that maintain activity in XII motoneurons, with the noradrenergic system playing a particularly prominent role in rats.
  • When noradrenergic and serotonergic drives are antagonized, no further decline of XII nerve activity occurs during pharmacologically induced rapid eye movement (REM) sleep-like state.
  • This is the best evidence to date that, at least in this model, the entire REM sleep-related decline of upper airway muscle tone results from withdrawal of these two excitatory inputs.
  • A major component of noradrenergic input to XII motoneurons originates from pontine noradrenergic neurons that have state-dependent patterns of activity, maximal during wakefulness, and minimal, or absent during REM sleep.
  • Our data suggest that not all ventrolateral medullary catecholaminergic neurons follow this pattern, with adrenergic C1 neurons probably increasing their activity during REM sleep.
  • When rats are subjected to chronic-intermittent hypoxia, noradrenergic drive to XII motoneurons is increased by mechanisms that include sprouting of noradrenergic terminals in the XII nucleus, and increased expression of α1-adrenoceptors; an outcome that may underlie the elevated baseline activity of upper airway muscles during wakefulness in OSA patients.

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  • [Copyright] © 2014 Elsevier B.V. All rights reserved.
  • (PMID = 24746052.001).
  • [ISSN] 1875-7855
  • [Journal-full-title] Progress in brain research
  • [ISO-abbreviation] Prog. Brain Res.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-47600; United States / NHLBI NIH HHS / HL / HL-60287; United States / NHLBI NIH HHS / HL / HL-74385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Netherlands
  • [Keywords] NOTNLM ; REM sleep / adrenergic receptors / atonia / genioglossus / norepinephrine / obstructive sleep apnea
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23. |||....... 35%  Tkacova R, McNicholas WT, Javorsky M, Fietze I, Sliwinski P, Parati G, Grote L, Hedner J, European Sleep Apnoea Database study collaborators: Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study. Eur Respir J; 2014 Oct;44(4):931-41
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  • [Title] Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study.
  • Systemic hypertension is associated with obstructive sleep apnoea syndrome (OSAS) but the pathophysiological mechanisms are incompletely understood.
  • A collaborative European network of 24 sleep centres established a European Sleep Apnoea Database to evaluate cardiovascular morbidity associated with OSAS.
  • 11 911 adults referred with suspected OSAS between March 2007 and September 2013 underwent overnight sleep studies, either cardiorespiratory polygraphy or polysomnography.
  • Both AHI and ODI independently related to prevalent hypertension after adjustment for relevant covariates (p<0.0001 for linear trend across quartiles (Q) of severity for both variables).
  • This cross sectional study suggests that chronic intermittent hypoxia plays an important role in OSAS-related hypertension.

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  • [Copyright] ©ERS 2014.
  • (PMID = 25102963.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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24. |||....... 35%  Chai LP, Xie X, Zeng YH, Wang ZF, Tu XP: [Rapid eye movement-related and none rapid eye movement-related classification in obstructive sleep apnea hypopnea syndrome]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2010 Feb;45(2):105-10
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  • [Title] [Rapid eye movement-related and none rapid eye movement-related classification in obstructive sleep apnea hypopnea syndrome].
  • OBJECTIVE: To study the value of a new measurement that divided obstructive sleep apnea-hypopnea syndrome (OSAHS) into rapid-eye-movement (REM) related and non-rapid-eye-movement (NREM) related subgroups.
  • METHODS: According to Siddiqui classification, 137 adult patients with OSHAS were diagnosed as REM-related OSAHS [REM apnea hypopnea index (AHI)/NREM AHI > 1] or NREM-related OSAHS (REM AHI/NREM AHI < 1).
  • (1) There were 72 cases defined as REM-related OSAHS (52.6%) and 65 cases defined as NREM-related OSAHS (47.4%). (2) In all cases, total AHI and NREM AHI in REM-related OSAHS were significantly lower than those in NREM-related OSAHS, while lowest arterial oxygen saturation (LSaO₂), REM LSaO₂ and NREM LSaO₂ were significantly higher than those in NREM-related OSAHS (t were -6.466, -7.638, 3.426, 2.472, 4.873 respectively, P < 0.05).
  • No significance was found in sleep structure, REM AHI and REM LSaO₂ between REM-related and NREM-related OSAHS (P > 0.05). (3) Given the severity of OSHAS, the constituent ratio of REM-related OSAHS decreased (77.8%, 61.5%, 37.3%) from mild to severe OSAHS, while that of NREM-related OSAHS rose (22.7%, 38.5%, 62.7%; chi² = 16.996, P < 0.01).
  • In mild and moderate groups, REM LSaO₂ of REM-related OSAHS was significantly lower than those in NREM-related OSAHS (t were -4.273 and -2.136, P < 0.05), while the differences of total AHI and LSaO₂, NREM LSaO₂ between these two types were not significant.
  • In severe group, AHI in NREM-related OSAHS was significantly higher than that in REM-related OSAHS, while LSaO₂, REM LSaO₂ and NREM LSaO₂ was significantly lower than those in REM-related OASHS (t were -4.943, 2.574, 1.996, 3.571, P ≤ 0.05). (4) There was no significance in sleeping latency and efficiency between REM-related and NREM-related OSHAS.
  • CONCLUSIONS: REM-related OSHAS mainly exists in mild and moderate OSHAS, while NREM-related one mainly exists in severe OSHAS.
  • NREM-related OSAHS may be more severe in AHI and hypoxia than REM-related one.
  • Whenever obstructive apnea happened in REM or NREM period, its impacts on sleep structure, efficiency and latency have no difference.
  • [MeSH-major] Sleep Apnea, Obstructive / classification. Sleep, REM
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Polysomnography. Sleep Stages. Young Adult

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  • (PMID = 20398503.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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25. |||....... 34%  Hui-guo L, Kui L, Yan-ning Z, Yong-jian X: Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia. Sleep Med; 2010 Feb;11(2):205-12
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  • [Title] Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia.
  • RATIONALE: The long-term intermittent hypoxia (LTIH) that characterizes sleep-disordered breathing impairs spatial learning and increases oxidative stress in rodents.
  • In untreated animals, LTIH exposure was related to increase of MDA levels in comparison to sham LTIH animals, and apocynin-treated animal exposure to LTIH showed reduction in MDA levels.
  • NADPH oxidase up-expression is closely associated with oxidative processes in LTIH rats, and inhibition of NADPH oxidase activity may hopefully serve as a useful strategy for cognitive function impairment from chronic intermittent hypoxia.

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  • [Copyright] 2009 Elsevier B.V. All rights reserved.
  • (PMID = 20083433.001).
  • [ISSN] 1878-5506
  • [Journal-full-title] Sleep medicine
  • [ISO-abbreviation] Sleep Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Acetophenones; 4Y8F71G49Q / Malondialdehyde; B6J7B9UDTR / acetovanillone; EC 1.15.1.1 / Superoxide Dismutase; EC 1.6.3.1 / NADPH Oxidase; EC 1.6.3.1 / neutrophil cytosolic factor 1; EC 1.6.3.1 / p22-phox protein, rat
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26. |||....... 34%  Vernet C, Redolfi S, Attali V, Konofal E, Brion A, Frija-Orvoen E, Pottier M, Similowski T, Arnulf I: Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms. Eur Respir J; 2011 Jul;38(1):98-105
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  • [Title] Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms.
  • 40 apnoeic patients, with (n = 20) and without (n = 20) RES, and 20 healthy controls underwent clinical interviews, cognitive and biological tests, polysomnography, a multiple sleep latency test, and 24-h sleep monitoring.
  • The marked subjective sleepiness in the RES group (mean ± sd score 16.4 ± 3) contrasted with moderately abnormal objective measures of sleepiness (90% of patients with RES had daytime sleep latencies >8 min).
  • Compared with patients without RES, the patients with RES had more fatigue, lower stage N3 percentages, more periodic leg movements (without arousals), lower mean sleep latencies and longer daytime sleep periods.
  • The association between RES, periodic leg movements, apathy and depressive mood parallels the post-hypoxic lesions in noradrenaline, dopamine and serotonin systems in animals exposed to intermittent hypoxia.
  • [MeSH-major] Disorders of Excessive Somnolence / diagnosis. Sleep Apnea, Obstructive / diagnosis
  • [MeSH-minor] Adult. Aged. Anoxia. Case-Control Studies. Fatigue. Female. France. Humans. Male. Middle Aged. Phenotype. Polysomnography. Sleep. Sleep Stages. Time Factors

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  • [CommentIn] Eur Respir J. 2011 Jul;38(1):7-8 [21719496.001]
  • [CommentIn] Eur Respir J. 2012 Jan;39(1):226-7; author reply 227-8 [22210820.001]
  • (PMID = 21406511.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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27. |||....... 34%  Ting Y, Nan-Fang L, Li-Gen A, Xiao-Guang Y, Jing H, Ling Z, Jian-Qiong K: Association of glucose transporter 4 gene polymorphism with hypoxia caused by obstructive sleep apnea syndrome and with related inflammatory factors. Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2014 Aug 31;36(4):400-9
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  • [Title] Association of glucose transporter 4 gene polymorphism with hypoxia caused by obstructive sleep apnea syndrome and with related inflammatory factors.
  • Objective To investigate the relationship between genetic polymorphisms of glucose transporter 4 (GLUT4) and hypoxia caused by obstructive sleep apnea syndrome (OSAS) as well as with related inflammatory factors.
  • A total of 859 subjects with possible OSAS base on their histories and physical examination findings udnerwent the polysomnography and inflammatory factor determination,of whom 616 (72%) were diagnosed with moderate and severe hypoxia with OSAS (case group) and 243(28%) without hypoxia or OASA (control group).
  • TaqMan PCR was used to genotyping then analyzed the relationship between locis of GLUT4 and hypoxia.
  • A significant association of GLUT4 SNP rs5417 allele carried in control subjects,compared with moderate and severe hypoxia in OSAS patients (P<0.05);AA+AC genotype relative to CC with low oxygen levels in subjects significantly reduced.
  • AA was still an independent protective factor for hypoxia caused by OSAS (OR=0.385,95%CI=0.210-0.704,P=0.002).
  • Male (OR=1.635,95%CI=1.037-2.577,P=0.034)and total cholesterol(OR=1.600,95%CI=1.287-1.987,P<0.001) were independent risk factors associated with hypoxia.
  • Normal weight(OR=0.059,95%CI=0.037-0.094,P<0.001) and high density lipoprotein cholesterol(OR=0.337,95%CI=0.171-0.666,P=0.002)were independent protective factors for hypoxia.
  • Conclusion Hypoxia caused by OSAS is associated with GLUT4 gene SNP rs5417.

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  • (PMID = 25176209.001).
  • [ISSN] 1000-503X
  • [Journal-full-title] Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
  • [ISO-abbreviation] Zhongguo Yi Xue Ke Xue Yuan Xue Bao
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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28. |||....... 34%  Nespoulet H, Wuyam B, Tamisier R, Saunier C, Monneret D, Remy J, Chabre O, Pépin JL, Lévy P: Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep. Eur Respir J; 2012 Sep;40(3):673-80
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  • [Title] Altitude illness is related to low hypoxic chemoresponse and low oxygenation during sleep.
  • We compared 12 AMS-susceptible individuals with recurrent and severe symptoms (AMS+) with 12 "AMS-nonsusceptible" subjects (AMS-), assessing sleep-breathing disorders in simulated altitude as well as chemoresponsive and pulmonary vasoconstrictive responses to hypoxia.
  • During exposure to simulated altitude, mean blood oxygen saturation during sleep was lower in AMS+ subjects (81.6 ± 2.6 versus 86.0 ± 2.4%, p<0.01), associated with a lower central apnoea/hypopnoea index (18.2 ± 18.1 versus 33.4 ± 24.8 events · h(-1) in AMS+ and AMS- subjects, respectively; p=0.038).
  • This represented the only significant and independent predictive factor for altitude intolerance, despite a higher increase in pulmonary artery systolic pressure in response to hypoxia, a lower lung diffusing capacity and a higher endothelin-1 level at baseline in AMS+ subjects (p<0.05).
  • AMS+ subjects were more hypoxaemic whilst exhibiting fewer respiratory events during sleep owing to lower hypoxic (isocapnic) chemoresponsiveness.
  • [MeSH-major] Altitude Sickness / physiopathology. Anoxia / physiopathology. Oxygen / blood. Sleep / physiology

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  • (PMID = 22523356.001).
  • [ISSN] 1399-3003
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Endothelin-1; S88TT14065 / Oxygen
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29. |||....... 34%  Donovan L, Welford SM, Haaga J, LaManna J, Strohl KP: Hypoxia--implications for pharmaceutical developments. Sleep Breath; 2010 Dec;14(4):291-8
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  • [Title] Hypoxia--implications for pharmaceutical developments.
  • Lowered oxygen availability (hypoxia) is theoretically important in the consideration of pharmacology because (1) hypoxia can alter cellular function and thereby the therapeutic effectiveness of the agent, (2) therapeutic agents may potentiate or protect against hypoxia-induced pathology, (3) hypoxic conditions may potentiate or mitigate drug-induced toxicity, (4) hypoxia may alter drug metabolism and thereby therapeutic effectiveness, and (5) therapeutic agents might alter the relative coupling of blood flow and energy metabolism in an organ.
  • The prototypic biochemical effect of hypoxia is related to its known role as a cofactor in a number of enzymatic reactions, e.g., oxidases and oxygenases, which are affected independently from the bioenergetic effect of low oxygen on energetic functions.
  • With chronic hypoxia, many of these processes are reversed, suggesting that hypoxia induces the drug-metabolizing systems.
  • Support for this comes from observations that hypoxia can induce the hypoxic inducible factors which in turn alters transcription and function of some but not all cytochrome P-450 isoforms.
  • Hypoxia is identified as a cofactor in cancer expression and metastatic potential.
  • Thus, the effects of hypoxia play an important role in pharmacology, and the signaling pathways that are affected by hypoxia could become new targets for novel therapy or avenues for prevention.
  • [MeSH-minor] Biotransformation / physiology. Cell Hypoxia / physiology. Cytochrome P-450 Enzyme System / physiology. Cytochromes c / physiology. Humans. Metabolic Detoxication, Drug / physiology

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  • (PMID = 20625934.001).
  • [ISSN] 1522-1709
  • [Journal-full-title] Sleep & breathing = Schlaf & Atmung
  • [ISO-abbreviation] Sleep Breath
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R33 HL087340; United States / NHLBI NIH HHS / HL / R33 HL087340-01A1
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-43-6 / Cytochromes c; 9035-51-2 / Cytochrome P-450 Enzyme System
  • [Other-IDs] NLM/ NIHMS223042; NLM/ PMC3236526
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30. |||....... 34%  Dale-Nagle EA, Hoffman MS, MacFarlane PM, Satriotomo I, Lovett-Barr MR, Vinit S, Mitchell GS: Spinal plasticity following intermittent hypoxia: implications for spinal injury. Ann N Y Acad Sci; 2010 Jun;1198:252-9
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  • [Title] Spinal plasticity following intermittent hypoxia: implications for spinal injury.
  • One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH).
  • pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain-derived neurotrophic factor, activation of its high-affinity receptor, tropomyosin-related kinase B, and extracellular-related kinase mitogen-activated protein kinase signaling in or near phrenic motor neurons.
  • Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury.
  • [MeSH-minor] Animals. Brain-Derived Neurotrophic Factor / physiology. Cervical Vertebrae / injuries. Enzyme Activation. Humans. Hypertension / etiology. Learning Disorders / etiology. Learning Disorders / physiopathology. Phrenic Nerve / physiology. Phrenic Nerve / physiopathology. Protein Kinase C / metabolism. Rats. Receptors, Serotonin, 5-HT2 / physiology. Respiratory Physiological Phenomena. Sleep Disorders / etiology. Sleep Disorders / physiopathology

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  • (PMID = 20536940.001).
  • [ISSN] 1749-6632
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / F31 HL092785; United States / NHLBI NIH HHS / HL / F31 HL092785-02; United States / NHLBI NIH HHS / HL / HL69064; United States / NHLBI NIH HHS / HL / HL80209; United States / NINDS NIH HHS / NS / NS05777; United States / NINDS NIH HHS / NS / P01 NS057778; United States / NINDS NIH HHS / NS / P01 NS057778-05; United States / NHLBI NIH HHS / HL / R01 HL080209; United States / NHLBI NIH HHS / HL / R01 HL080209-06; United States / NHLBI NIH HHS / HL / R37 HL069064; United States / NHLBI NIH HHS / HL / R37 HL069064-10; United States / NIGMS NIH HHS / GM / T32 GM008692; United States / NHLBI NIH HHS / HL / T32 HL007654; United States / NHLBI NIH HHS / HL / T32 HL007654-25; United States / NHLBI NIH HHS / HL / T32HL07654
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Brain-Derived Neurotrophic Factor; 0 / Receptors, Serotonin, 5-HT2; EC 2.7.11.13 / Protein Kinase C
  • [Number-of-references] 60
  • [Other-IDs] NLM/ NIHMS261289; NLM/ PMC3030965
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31. |||....... 34%  Stettner GM, Fenik VB, Kubin L: Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons. J Appl Physiol (1985); 2012 Jan;112(2):305-12
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  • [Title] Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons.
  • In obstructive sleep apnea patients, elevated activity of the lingual muscles during wakefulness protects the upper airway against occlusions.
  • A possibly related form of respiratory neuroplasticity is present in rats exposed to acute and chronic intermittent hypoxia (CIH).
  • [MeSH-major] Adrenergic Neurons / metabolism. Anoxia / physiopathology. Hypoglossal Nerve / physiology. Motor Neurons / physiology. Receptors, Adrenergic / metabolism. Sleep Apnea, Obstructive

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  • (PMID = 22016369.001).
  • [ISSN] 1522-1601
  • [Journal-full-title] Journal of applied physiology (Bethesda, Md. : 1985)
  • [ISO-abbreviation] J. Appl. Physiol.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-047600
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adrenergic alpha-1 Receptor Antagonists; 0 / Receptors, Adrenergic; X4W3ENH1CV / Norepinephrine; XM03YJ541D / Prazosin
  • [Other-IDs] NLM/ PMC3349609
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32. |||....... 33%  Roisman G, Ibrahim I, Escourrou P: [Why and how to diagnose sleep respiratory disorders?]. Rev Pneumol Clin; 2009 Aug;65(4):203-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Why and how to diagnose sleep respiratory disorders?].
  • Gas exchange abnormalities occur firstly during sleep in restrictive and obstructive chronic respiratory failure.
  • Nocturnal hypoxemia is often a revealing feature of a sleep-related hypoventilation/hypoxemia syndrome in patients who will have later a diurnal hypoxemia.
  • On the other hand, sleep may induce breathing abnormalities in individuals without lung diseases, like in obstructive sleep apnea syndrome (OSAS).
  • In OSAS, repeated closure and/or narrowing of the pharynx during sleep increases the inspiratory effort and induces sleep fragmentation.
  • Besides its direct consequences on sleep, OSAS is also associated with an increased risk of cardiovascular morbi-mortality.
  • Reduced daytime alertness and cognitive functions are usually present in patients with sleep-disordered breathing.
  • These features are believed to be related to both sleep fragmentation and nocturnal hypoxia/hypercapnia.
  • Sleep-related hypoventilation/hypoxemia and pharyngeal obstructive events may occur together in patients with respiratory insufficiency, especially in obese and/or chronic obstructive pulmonary disease (COPD) subjects.
  • A correct qualitative and quantitative assessment of sleep-disordered breathing may only be performed by recording specific physiological signals during sleep.
  • [MeSH-major] Sleep Apnea Syndromes / diagnosis

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  • (PMID = 19789046.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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33. |||....... 33%  Julian GS, de Oliveira RW, Perry JC, Tufik S, Chagas JR: Validation of housekeeping genes in the brains of rats submitted to chronic intermittent hypoxia, a sleep apnea model. PLoS One; 2014;9(10):e109902
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  • [Title] Validation of housekeeping genes in the brains of rats submitted to chronic intermittent hypoxia, a sleep apnea model.
  • Obstructive sleep apnea (OSA) is a syndrome characterized by intermittent nocturnal hypoxia, sleep fragmentation, hypercapnia and respiratory effort, and it has been associated with several complications, such as diabetes, hypertension and obesity.
  • Quantitative real-time PCR has been performed in previous OSA-related studies; however, these studies were not validated using proper reference genes.
  • We have examined the effects of chronic intermittent hypoxia (CIH), which is an experimental model mainly of cardiovascular consequences of OSA, on reference genes, including beta-actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hypoxanthine guanine phosphoribosyl transferase and eukaryotic 18S rRNA, in different areas of the brain.

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  • (PMID = 25289636.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC4188622
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34. |||....... 33%  Rambaud C, Guilleminault C: Death, nasomaxillary complex, and sleep in young children. Eur J Pediatr; 2012 Sep;171(9):1349-58
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  • [Title] Death, nasomaxillary complex, and sleep in young children.
  • This is an investigation of anatomical and sleep history risk factors that were associated with abrupt sleep-associated death in seven children with good pre-mortem history.
  • Seven young children with abrupt deaths and information on health status, sleep history, death scene report, and autopsy performed in a specialized unit dedicated to investigation of abrupt death in young children were investigated Seven age and gender matched living children with obstructive-sleep-apnea (OSA) were compared to the findings obtained from the dead children.
  • History revealed presence of chronic indicators of abnormal sleep in all cases prior death and history of an acute, often mild, rhinitis just preceding death in several.
  • All children were concluded to have died of hypoxia during sleep.
  • Their presence should lead to greater attention to sleep-related complaints that may be present very early in life and indicate impairment of well been and presence of sleep disruption.
  • [MeSH-major] Anoxia / mortality. Death, Sudden / etiology. Maxilla / pathology. Nose / pathology. Sleep Apnea, Obstructive / complications

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  • (PMID = 22492014.001).
  • [ISSN] 1432-1076
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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35. |||....... 32%  Csábi E, Janacsek K, Várszegi M, Németh D: [Different effect of sleep on working memory and skill learning: cognitive function in obstructive sleep apnea]. Psychiatr Hung; 2011;26(2):78-86
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  • [Title] [Different effect of sleep on working memory and skill learning: cognitive function in obstructive sleep apnea].
  • In obstructive sleep apnea syndrome (OSAS) hypoxia and sleep deprivation lead to neuropsychological impairments.
  • Our goal in this study to evaluate working memory and skill learning to get a complex picture about cortical and sub-cortical function in patients with sleep apnea.
  • These findings suggest that sleep has less influence on the functions related to sub-cortical structures like cortical functions.
  • [MeSH-major] Cognition. Cognition Disorders / psychology. Learning. Memory, Short-Term. Motor Skills. Sleep. Sleep Apnea, Obstructive / psychology

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  • (PMID = 21653993.001).
  • [ISSN] 0237-7896
  • [Journal-full-title] Psychiatria Hungarica : A Magyar Pszichiátriai Társaság tudományos folyóirata
  • [ISO-abbreviation] Psychiatr Hung
  • [Language] hun
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Hungary
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36. |||....... 32%  Querido JS, Sheel AW, Cheema R, Van Eeden S, Mulgrew AT, Ayas NT: Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans. Sleep Breath; 2012 Sep;16(3):657-62
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  • [Title] Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans.
  • PURPOSE: Obstructive sleep apnea (OSA) is a common disease which is associated with elevated inflammatory markers and adhesion molecules, possibly due to nightly intermittent hypoxia (IH).
  • METHODS: Healthy, young male subjects (n = 9; 24 ± 2 years) were exposed to a single daily isocapnic hypoxia exposure (oxyhemoglobin saturation = 80%, 1 h/day) for 10 consecutive days.
  • The mean oxyhemoglobin saturation was 80.8 ± 1.6% during the hypoxia exposures.
  • CONCLUSIONS: These findings suggest that (1) a more substantial or a different pattern of hypoxemia might be necessary to activate systemic inflammation, (2) the system may need to be primed before hypoxic exposure, or (3) increases in inflammatory markers in patients with OSA may be more related to other factors such as obesity or nocturnal arousal.
  • [MeSH-major] Anoxia / physiopathology. Inflammation Mediators / metabolism. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 21743982.001).
  • [ISSN] 1522-1709
  • [Journal-full-title] Sleep & breathing = Schlaf & Atmung
  • [ISO-abbreviation] Sleep Breath
  • [Language] eng
  • [Grant] Canada / Canadian Institutes of Health Research / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Inflammation Mediators; S88TT14065 / Oxygen
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37. |||....... 32%  Arnaud C, Dematteis M, Pepin JL, Baguet JP, Lévy P: Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin Immunopathol; 2009 Jun;31(1):113-25
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  • [Title] Obstructive sleep apnea, immuno-inflammation, and atherosclerosis.
  • Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder leading to cardiovascular and metabolic complications.
  • OSA is also a multicomponent disorder, with intermittent hypoxia (IH) as the main trigger for the associated cardiovascular and metabolic alterations.
  • Indeed, recurrent pharyngeal collapses during sleep lead to repetitive sequences of hypoxia-reoxygenation.
  • Atherosclerosis has been found in OSA patients free of other cardiovascular risk factors and is related to the severity of nocturnal hypoxia.
  • The intimate molecular mechanisms are still largely unknown, and their understanding may contribute to delineate new targets for prevention strategies and/or development of new treatment of OSA-related atherosclerosis, especially in patients at risk for cardiovascular disease.
  • [MeSH-major] Atherosclerosis / immunology. Sleep Apnea, Obstructive / immunology

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  • (PMID = 19404644.001).
  • [ISSN] 1863-2300
  • [Journal-full-title] Seminars in immunopathology
  • [ISO-abbreviation] Semin Immunopathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adipokines
  • [Number-of-references] 161
  • [Other-IDs] NLM/ HALMS786340; NLM/ PMC3937574
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38. |||....... 32%  Xiang YH, Su XL, Hu CP, Luo YQ, He RX: [A study of the related pathways of oxidative stress in chronic intermittent hypoxia rats and the effect of N-acetylcysteine]. Zhonghua Jie He He Hu Xi Za Zhi; 2010 Dec;33(12):912-6
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  • [Title] [A study of the related pathways of oxidative stress in chronic intermittent hypoxia rats and the effect of N-acetylcysteine].
  • OBJECTIVE: To study the relation of oxidative stress with systolic blood pressure (SBP) and renin-agiotensin system (RAS) in a rat model of chronic intermittent hypoxia (CIH), and to investigate the preventive effect and mechanism of N-acetylcysteine (NAC) in CIH-induced hypertension.
  • CIH rats were subjected to alternating cycles of hypoxia (6%-8% O2 in N2 for 20-25 s) and normoxia (21% O2 in N2 for 2 min) every 180 s for 7 h per day.
  • The imbalance of RAS in CIH rats was related with oxidative stress.
  • [MeSH-minor] Animals. Blood Pressure. Male. Rats. Rats, Sprague-Dawley. Renin-Angiotensin System. Sleep Apnea, Obstructive / metabolism

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  • (PMID = 21211411.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antioxidants; WYQ7N0BPYC / Acetylcysteine
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39. |||....... 32%  Jun J, Polotsky VY: Metabolic consequences of sleep-disordered breathing. ILAR J; 2009;50(3):289-306
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  • [Title] Metabolic consequences of sleep-disordered breathing.
  • There is increasing evidence of a causal relationship between sleep-disordered breathing and metabolic dysfunction.
  • Excess caloric intake is indisputably the key driver of MetS, but other environmental and genetic factors likely play a role; in particular, obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may induce or exacerbate various aspects of MetS.
  • In the most widely used model, which involves exposing rodents to IH during their sleep phase, the IH alters circadian glucose homeostasis, impairs muscle carbohydrate uptake, induces hyperlipidemia, and upregulates cholesterol synthesis enzymes.
  • Mechanisms for these effects are not yet fully understood, but are likely related to energy-conserving adaptations to hypoxia, which is a strong catabolic stressor.
  • [MeSH-major] Metabolic Diseases / etiology. Sleep Apnea Syndromes / complications
  • [MeSH-minor] Animals. Anoxia / complications. Anoxia / physiopathology. Dyslipidemias / etiology. Dyslipidemias / physiopathology. Humans. Liver Diseases / etiology. Liver Diseases / physiopathology. Mice. Obesity / etiology. Obesity / physiopathology. Rats. Sleep Deprivation / etiology. Sleep Deprivation / physiopathology

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  • (PMID = 19506316.001).
  • [ISSN] 1930-6180
  • [Journal-full-title] ILAR journal / National Research Council, Institute of Laboratory Animal Resources
  • [ISO-abbreviation] ILAR J
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / 5P50HL084945; United States / NHLBI NIH HHS / HL / R01 HL80105; United States / NHLBI NIH HHS / HL / T32 HL07534
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 239
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40. |||....... 32%  Onen F, Onen H: [Obstructive sleep apnea and cognitive impairment in the elderly]. Psychol Neuropsychiatr Vieil; 2010 Sep;8(3):163-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Obstructive sleep apnea and cognitive impairment in the elderly].
  • Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repeated episodes of upper airway obstruction during sleep that result in intermittent hypoxemia and arousal.
  • OSAS causes hypoxia, fragmented sleep, daytime sleepiness, cognitive dysfunction, functional decline, and brain damage resulting from reduced cerebral blood flow, ischemic brain lesions, microvascular reactivity, white matter lesions, and grey matter loss.
  • OSAS-related cognitive dysfunction has been shown in a variety of domains including attention, executive functioning, motor efficiency, working memory, and long-term episodic memory.
  • Proposed mechanisms include hypoxemia, sleep fragmentation and inflammatory process, but it remains unclear which mechanisms underlie the relationship between OSAS and disturbances in the different cognitive domains.
  • [MeSH-major] Cognition Disorders / etiology. Sleep Apnea, Obstructive / diagnosis
  • [MeSH-minor] Aged. Alzheimer Disease / diagnosis. Alzheimer Disease / epidemiology. Alzheimer Disease / etiology. Brain Damage, Chronic / complications. Brain Damage, Chronic / diagnosis. Brain Damage, Chronic / epidemiology. Continuous Positive Airway Pressure. Cross-Sectional Studies. Humans. Hypoxia, Brain / complications. Hypoxia, Brain / diagnosis. Hypoxia, Brain / epidemiology. Neuropsychological Tests

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  • (PMID = 20739254.001).
  • [ISSN] 1760-1703
  • [Journal-full-title] Psychologie & neuropsychiatrie du vieillissement
  • [ISO-abbreviation] Psychol Neuropsychiatr Vieil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
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41. |||....... 31%  Estrada KD, Chesler NC: Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia. Biomech Model Mechanobiol; 2009 Aug;8(4):263-72
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  • [Title] Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia.
  • Collagen accumulation likely contributes to increased vascular and airway impedance in hypoxia-induced pulmonary hypertension (HPH).
  • To better understand the individual contributions of fibrillar (FB) and basement membrane (BM) collagen, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) to pulmonary vascular and airway remodeling in HPH, we investigated the temporal changes in gene and protein expression in the lungs of mice exposed to hypoxia for 0, 3, 6, 10 and 15 days.
  • The earliest and largest change in gene expression was of type I FB collagen, which was significantly increased over control levels at 6, 10 and 15 days of hypoxia (p < 0.05).
  • Type III FB and type IV BM collagen were increased at 10 and 15 days of hypoxia (p < 0.05); MMP and TIMP gene expression levels were typically higher but sometimes lower than control levels at various time points.
  • Collagen protein content was increased in whole lungs as early as 6 days of hypoxia and increased monotonically with longer exposures.
  • These results provide insight into the patterns of gene and protein expression relevant to collagen accumulation in the lung in response to chronic hypoxia, through which we can develop a better understanding of the time course of changes in matrix biology and biomechanics that occur in HPH.

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  • (PMID = 18642127.001).
  • [ISSN] 1617-7940
  • [Journal-full-title] Biomechanics and modeling in mechanobiology
  • [ISO-abbreviation] Biomech Model Mechanobiol
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / R01 HL086939; United States / NHLBI NIH HHS / HL / R01 HL086939-01A1; United States / NHLBI NIH HHS / HL / R01 HL086939-02; United States / NHLBI NIH HHS / HL / R01HL086939
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 9007-34-5 / Collagen; RMB44WO89X / Hydroxyproline
  • [Other-IDs] NLM/ NIHMS60119; NLM/ PMC2718063
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42. |||....... 31%  Sun W, Yin X, Wang Y, Tan Y, Cai L, Wang B, Cai J, Fu Y: Intermittent hypoxia-induced renal antioxidants and oxidative damage in male mice: hormetic dose response. Dose Response; 2012;11(3):385-400
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  • [Title] Intermittent hypoxia-induced renal antioxidants and oxidative damage in male mice: hormetic dose response.
  • Obstructive sleep apnea causes cardiovascular disease via chronic intermittent hypoxia (IH), which may be related to oxidative stress.
  • Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important cellular defense mechanism against oxidative stress by regulating its down-stream multiple antioxidants.

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  • (PMID = 23983666.001).
  • [ISSN] 1559-3258
  • [Journal-full-title] Dose-response : a publication of International Hormesis Society
  • [ISO-abbreviation] Dose Response
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3748850
  • [Keywords] NOTNLM ; Intermittent hypoxia / Nrf2 / kidney hypoxic damage / metallothionein
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43. |||....... 31%  Gonzalez-Martín MC, Vega-Agapito MV, Conde SV, Castañeda J, Bustamante R, Olea E, Perez-Vizcaino F, Gonzalez C, Obeso A: Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input. J Cell Physiol; 2011 Aug;226(8):1961-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Carotid body function and ventilatory responses in intermittent hypoxia. Evidence for anomalous brainstem integration of arterial chemoreceptor input.
  • Obstructive sleep apnea is a frequent medical condition consisting in repetitive sleep-related episodes of upper airways obstruction and concurrent events of arterial blood hypoxia.
  • There is a frequent association of cardiovascular diseases and other pathologies to this condition conforming the obstructive sleep apnea syndrome (OSAS).
  • Laboratory models of OSAS consist in animals exposed to repetitive episodes of intermittent hypoxia (IH) which also develop cardiovascular pathologies, mostly hypertension.
  • The overall OSAS pathophysiology appears to be linked to the repetitive hypoxia, which would cause a sensitization of carotid body (CB) chemoreflex and chemoreflex-driven hyperreactivity of the sympathetic nervous system.
  • The efferent activity was measured as ventilation in normoxia, hypoxia, and hypercapnia.
  • Findings indicate a sensitization of the CB function to hypoxia evidenced by exaggerated chemoreceptor cell and CB afferent activity.
  • [MeSH-minor] Animals. Hypercapnia / physiopathology. Hypertension / physiopathology. Male. Norepinephrine / metabolism. Norepinephrine / physiology. Rats. Rats, Wistar. Renal Artery / physiopathology. Sleep Apnea, Obstructive / physiopathology. Sympathetic Nervous System / physiopathology

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 21520047.001).
  • [ISSN] 1097-4652
  • [Journal-full-title] Journal of cellular physiology
  • [ISO-abbreviation] J. Cell. Physiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] X4W3ENH1CV / Norepinephrine
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44. |||....... 31%  Khan AM, Ashizawa S, Hlebowicz V, Appel DW: Anemia of aging and obstructive sleep apnea. Sleep Breath; 2011 Jan;15(1):29-34
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  • [Title] Anemia of aging and obstructive sleep apnea.
  • Among elderly with obstructive sleep apnea (OSA), hypoxic stimulation of erythropoiesis may obscure AOA.
  • Hemogram changes were compared to apnea-hypopnea index (AHI), respiratory effort related arousals (RERA), and duration patients slept with oxyhemoglobin saturation <89% (hypoxic time (HT)) and were assessed for correlative significance using Pearson coefficient correlation.
  • While these Hct changes did not correlate significantly with selected sleep-breathing variables, we remain intrigued by a possible AOA-OSA interaction.
  • We believe OSA inflammatory processes interact with OSA hypoxia-induced erythropoiesis.
  • [MeSH-major] Anemia / blood. Anemia / therapy. Sleep Apnea, Obstructive / blood. Sleep Apnea, Obstructive / therapy


45. |||....... 31%  Minville C, Hilleret MN, Tamisier R, Aron-Wisnewsky J, Clement K, Trocme C, Borel JC, Lévy P, Zarski JP, Pépin JL: Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea. Chest; 2014 Mar 1;145(3):525-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonalcoholic fatty liver disease, nocturnal hypoxia, and endothelial function in patients with sleep apnea.
  • BACKGROUND: Nocturnal hypoxia, the hallmark of OSA, is a potential contributing factor for nonalcoholic fatty liver disease (NAFLD).
  • NAFLD severity and its implication in OSA-related endothelial dysfunction have not been investigated in a large, unselected OSA population, including nonobese subjects.
  • The dose-response relationship between the severity of nocturnal hypoxia and liver injury was established only in morbid obesity and not in lean.
  • CONCLUSIONS: In a large, unselected OSA population, the severity of nocturnal hypoxia was independently associated with steatosis.
  • [MeSH-major] Anoxia / complications. Endothelium, Vascular / physiopathology. Fatty Liver / etiology. Sleep Apnea, Obstructive / complications. Vasodilation / physiology

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  • [CommentIn] Chest. 2014 Aug;146(2):e67 [25091772.001]
  • [CommentIn] Chest. 2014 Aug;146(2):e67-8 [25091773.001]
  • (PMID = 24264333.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Non-alcoholic Fatty Liver Disease
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46. |||....... 31%  Park SY, Kim SM, Sung JJ, Lee KM, Park KS, Kim SY, Nam HW, Lee KW: Nocturnal hypoxia in ALS is related to cognitive dysfunction and can occur as clusters of desaturations. PLoS One; 2013;8(9):e75324
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  • [Title] Nocturnal hypoxia in ALS is related to cognitive dysfunction and can occur as clusters of desaturations.
  • Consequently, most patients with ALS exhibit progressive hypoventilation, which worsens during sleep.
  • The aim of this study was to evaluate the relationship between nocturnal hypoxia and cognitive dysfunction and to assess the pattern of nocturnal hypoxia in patients with ALS.
  • Patients were grouped according to the presence of nocturnal hypoxia (SpO2<95% for ≥10% of the night) and their clinical characteristics and cognitive function were compared.
  • RESULTS: Compared to patients without nocturnal hypoxia, those with nocturnal hypoxia (n = 10, 40%) had poor memory retention (p = 0.039) and retrieval efficiency (p = 0.045).
  • A cluster-of-desaturation pattern was identified in 7 patients (70%) in the Hypoxia Group.
  • CONCLUSIONS: These results suggest that nocturnal hypoxia can be related to cognitive dysfunction in ALS.
  • In addition, a considerable number of patients with ALS may be exposed to repeated episodes of deoxygenation-reoxygenation (a cluster-of-desaturation pattern) during sleep, which could be associated with the generation of reactive oxygen species.

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  • (PMID = 24058674.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3776791
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47. |||....... 31%  Perry JC, Guindalini C, Bittencourt L, Garbuio S, Mazzotti DR, Tufik S: Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans. Respir Physiol Neurobiol; 2013 Dec 1;189(3):649-54
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  • [Title] Whole blood hypoxia-related gene expression reveals novel pathways to obstructive sleep apnea in humans.
  • In this study, our goal was to identify the key genes that are associated with obstructive sleep apnea (OSA).
  • Thirty-five volunteers underwent full in-lab polysomnography and, according to the sleep apnea hypopnea index (AHI), were classified into control, mild-to-moderate OSA and severe OSA groups.
  • [MeSH-major] Gene Expression Regulation / physiology. Sleep Apnea, Obstructive / metabolism

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  • [Copyright] Copyright © 2013 Elsevier B.V. All rights reserved.
  • (PMID = 23994550.001).
  • [ISSN] 1878-1519
  • [Journal-full-title] Respiratory physiology & neurobiology
  • [ISO-abbreviation] Respir Physiol Neurobiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Carrier Proteins; 0 / PRPF40A protein, human; 0 / RNA, Messenger; EC 1.14.11.4 / Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
  • [Keywords] NOTNLM ; CPAP / Gene expression / Hypoxia / Obstructive sleep apnea / Sleep
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48. |||....... 31%  Rukhadze I, Fenik VB, Benincasa KE, Price A, Kubin L: Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. Am J Respir Crit Care Med; 2010 Nov 15;182(10):1321-9
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  • [Title] Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus.
  • RATIONALE: Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness.
  • Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory drive to upper airway motoneurons.
  • We tested whether chronic intermittent hypoxia (CIH), a major pathogenic factor of OSA, affects aminergic innervation of XII motoneurons that innervate tongue-protruding muscles in a manner that could alter their airway-dilatory action.
  • [MeSH-minor] Animals. Cell Count. Humans. Male. Motor Neurons / pathology. Motor Neurons / physiology. Norepinephrine / physiology. Rats. Rats, Sprague-Dawley. Receptor, Serotonin, 5-HT2A / physiology. Receptors, Adrenergic, alpha-1 / physiology. Serotonin / physiology. Sleep Apnea, Obstructive / pathology. Sleep Apnea, Obstructive / physiopathology

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  • (PMID = 20622040.001).
  • [ISSN] 1535-4970
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Grant] United States / NHLBI NIH HHS / HL / HL-047600; United States / NHLBI NIH HHS / HL / HL-074385
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptor, Serotonin, 5-HT2A; 0 / Receptors, Adrenergic; 0 / Receptors, Adrenergic, alpha-1; 0 / Receptors, Serotonin; 333DO1RDJY / Serotonin; X4W3ENH1CV / Norepinephrine
  • [Other-IDs] NLM/ PMC3001268
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49. |||....... 31%  Sans Capdevila O, Wienberg P, Haag O, Cols M: [Comorbidities of sleep-disordered breathing in children]. Acta Otorrinolaringol Esp; 2010 Dec;61 Suppl 1:26-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Comorbidities of sleep-disordered breathing in children].
  • Sleep-related respiratory disorders in children, especially childhood sleep apnea-hypopnea syndrome, are associated with a wide range of comorbidities affecting the central nervous system, cardiovascular and metabolic systems, and growth.
  • The two most important factors contributing to the physiopathology of this disorder are intermittent hypoxia and sleep fragmentation, which seem to cause the systemic inflammatory response resulting in these end-organ consequences.
  • [MeSH-major] Sleep Apnea Syndromes / complications

  • MedlinePlus Health Information. consumer health - Sleep Apnea.
  • ExactAntigen/Labome. author profiles.
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  • [Copyright] Copyright © 2010 Elsevier España S.L. All rights reserved.
  • (PMID = 21354490.001).
  • [ISSN] 1988-3013
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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50. |||....... 31%  Huang Y, Liu YH: Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity. Eur J Oral Sci; 2011 Apr;119(2):128-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of phytoestrogens on genioglossus contractile properties in ovariectomized rats exposed to chronic intermittent hypoxia may be independent of their estrogenicity.
  • Chronic intermittent hypoxia (CIH) is a frequent feature of obstructive sleep apnea/hypopnea syndrome (OSAHS), and it may alter upper airway muscle endurance.
  • We conclude that phytoestrogens, especially genistein, could improve the endurance of the genioglossus muscle in ovariectomized rats exposed to CIH, and this effect is, in part, not related to its estrogenic action.
  • [MeSH-major] Coumestrol / pharmacology. Genistein / pharmacology. Muscle Contraction / drug effects. Muscle, Skeletal / drug effects. Phytoestrogens / pharmacology. Sleep Apnea, Obstructive / metabolism

  • HSDB. structure - GENISTEIN.
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  • [Copyright] © 2011 Eur J Oral Sci.
  • (PMID = 21410552.001).
  • [ISSN] 1600-0722
  • [Journal-full-title] European journal of oral sciences
  • [ISO-abbreviation] Eur. J. Oral Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Phytoestrogens; 0 / RNA, Messenger; 0 / Receptors, Estrogen; DH2M523P0H / Genistein; V7NW98OB34 / Coumestrol
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