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1. Biomedical articles (top 50; 2010 to 2015)
1. Kim CW, Kim MJ, Park SB, Han SH: A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia. Ann Rehabil Med; 2012 Feb;36(1):144-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia.
  • From the results of the magnetic resonance imaging (MRI), synovial proliferative disease, infectious arthritis, or gouty arthritis was suspected.
  • We performed a blood laboratory test to detect rheumatologic diseases, knee joint aspiration, and bone scan for differential diagnosis, and were able to diagnose rheumatoid arthritis (RA) from the results of blood laboratory, physical examination, and bone scan.
  • Herein, we report a case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia.
  • If a right hemiplegic patient has recurrent pain on the left knee and synovial hypertrophy, and fails to respond to treatment for osteoarthritis, early detection by evaluation for rheumatic disease is crucial to prevent severe sequelae influencing rehabilitation of hemiplegia.

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  • (PMID = 22506248.001).
  • [ISSN] 2234-0653
  • [Journal-full-title] Annals of rehabilitation medicine
  • [ISO-abbreviation] Ann Rehabil Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC3309335
  • [Keywords] NOTNLM ; Hemiplegia / Rheumatoid arthritis / Synovial hypertrophy
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2. Jain K, Singh R: Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy. Singapore Med J; 2014 Oct;55(10):547-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy.
  • INTRODUCTION: Arthroscopic excision of the hypertrophic dorsal synovium is performed on patients with dorsal wrist pain in hyperextension.
  • Although dorsal wrist impingement has been described in cadaveric studies, to our knowledge, there is no published clinical data on its treatment with arthroscopic synovial excision.
  • METHOD: A total of 13 patients underwent arthroscopic excision of the hypertrophic dorsal impinging synovium.
  • CONCLUSION: When treating patients with dorsal wrist pain, dorsal wrist impingement caused by synovial hypertrophy should be included in the differential diagnosis.
  • Arthroscopic excision of the impinging synovium can achieve reliable pain relief with significant functional improvement in the short term, although further research on its long-term benefits is required.

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  • (PMID = 25631897.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
  • [Other-IDs] NLM/ PMC4293966
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3. Kara A, Celik H, Seker A, Sezer HB, Kilinc E, Uzun M: Ochronosis diagnosed after knee arthroscopy. Int J Surg Case Rep; 2014;5(8):497-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: Ochronosis is a rare disorder which is defined as the deposition of metabolites of oxidation and polymerization of homogentisic acid, which have high affinity to collogen, in the connective tissues.
  • The arthroscopic examination of right knee revealed black colored synovial hypertrophy and torn lateral meniscus.
  • The diagnosis of ochronosis was made after histopathologic examination.
  • Our patient had meniscal tear, cartilage damage and black discoloration of synovial tissues and meniscus.
  • CONCLUSION: Arthroscopy may be helpful in diagnosis of ochronotic arthropathy.

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  • [Copyright] Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
  • (PMID = 24993694.001).
  • [ISSN] 2210-2612
  • [Journal-full-title] International journal of surgery case reports
  • [ISO-abbreviation] Int J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Other-IDs] NLM/ PMC4147474
  • [Keywords] NOTNLM ; Arthroscopy / Knee / Ochronosis
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4. Hall M, Doherty S, Courtney P, Latief K, Zhang W, Doherty M: Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms. Osteoarthritis Cartilage; 2014 Oct;22(10):1627-33
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms.
  • All underwent assessment for pain, knee radiographs and US examination for effusion, synovial hypertrophy, popliteal cysts and power Doppler (PD) signal within the synovium.
  • Effusion and synovial hypertrophy were more common in ROA and SROA participants.
  • Severity of effusion and synovial hypertrophy were greater in SROA compared to ROA (P < 0.05).
  • Severity of US effusion and synovial hypertrophy were correlated with radiographic severity (r = 0.6 and r = 0.7, P < 0.01) but the relationship between pain severity and US features was weak (r = 0.3, P < 0.01).
  • In SROA participants, pain severity did not change in tandem with a change in synovial hypertrophy over time.
  • Effusion and synovial hypertrophy were moderately correlated with radiographic severity but the relationship with pain is less strong.
  • [MeSH-major] Arthralgia / ultrasonography. Osteoarthritis, Knee / ultrasonography. Synovial Membrane / ultrasonography. Synovitis / ultrasonography
  • [MeSH-minor] Aged. Aged, 80 and over. Asymptomatic Diseases. Case-Control Studies. Female. Humans. Hypertrophy. Male. Middle Aged. Severity of Illness Index

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  • [Copyright] Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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  • (PMID = 25278071.001).
  • [ISSN] 1522-9653
  • [Journal-full-title] Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
  • [ISO-abbreviation] Osteoarthr. Cartil.
  • [Language] eng
  • [Grant] United Kingdom / Arthritis Research UK / / 18860
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC4192137
  • [Keywords] NOTNLM ; Inflammation / Knee osteoarthritis / Pain / Synovitis / Ultrasound
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5. Gajjar SM, Platts A, Dowd G: Synovial hypertrophy causing recurrent hemarthrosis after total knee replacement. J Knee Surg; 2010 Mar;23(1):25-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synovial hypertrophy causing recurrent hemarthrosis after total knee replacement.
  • We report three patients with late-onset recurrent hemarthrosis following total knee replacement due to synovial hypertrophy and impingement, which were successfully treated by embolization.
  • [MeSH-major] Arthroplasty, Replacement, Knee / adverse effects. Hemarthrosis / etiology. Synovial Membrane / pathology
  • [MeSH-minor] Aged. Embolization, Therapeutic. Female. Humans. Hypertrophy / complications. Hypertrophy / etiology. Male. Middle Aged. Recurrence

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  • (PMID = 20812578.001).
  • [ISSN] 1538-8506
  • [Journal-full-title] The journal of knee surgery
  • [ISO-abbreviation] J Knee Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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6. Laurell L, Court-Payen M, Nielsen S, Zak M, Boesen M, Fasth A: Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the ankle region. A descriptive interventional study. Pediatr Rheumatol Online J; 2011;9(1):4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the ankle region. A descriptive interventional study.
  • Doppler-US detected synovial hypertrophy, effusion and hyperemia and US was used for guidance of steroid injection and to assess treatment efficacy.
  • All patients were assessed clinically, by US (synovial hypertrophy, effusion) and by color Doppler (synovial hyperemia) before and 4 weeks after US-guided steroid injection.
  • Normalization or regression of synovial hypertrophy was obtained in 89%, and normalization of synovial hyperemia in 89%.
  • CONCLUSIONS: US enabled exact anatomical location of synovial inflammation in the ankle region of JIA patients.
  • Normalization or regression of synovial hypertrophy and hyperemia was achieved in most cases, which supports the notion that US is an important tool in the management of ankle involvement in JIA.

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  • (PMID = 21276257.001).
  • [ISSN] 1546-0096
  • [Journal-full-title] Pediatric rheumatology online journal
  • [ISO-abbreviation] Pediatr Rheumatol Online J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3041992
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7. 'Synovial Hypertrophy Disorder': Top Publications. BioMedLib Review OC; ;SynovialHypertrophyDisorder:709904995. ISSN: 2331-5717. 2015/2/10; updates online.
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  • [Title] 'Synovial Hypertrophy Disorder': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy disorder'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 8 publications, and group two 514 publications.
  • Here are the top 4.
  • Scharstuhl A et al: Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
  • Chow JC et al: Hypertrophy of the synovium in the anteromedial aspect of the knee joint following trauma: an unusual cause of knee pain.
  • Fernandez-Madrid F et al: Synovial thickening detected by MR imaging in osteoarthritis of the knee confirmed by biopsy as synovitis.
  • Hill CL et al: Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709904995.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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8. Tezcan ME, Ekinci O, Uçar M, Göker B: Sterile osteitis and suppurative arthritis associated with pannus responding to colchicine. Case Rep Rheumatol; 2013;2013:249471
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • However, he had clinical response to colchicine and the synovial hypertrophy and the pannus in the MRI of his left shoulder resolved.

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  • (PMID = 23984159.001).
  • [ISSN] 2090-6889
  • [Journal-full-title] Case reports in rheumatology
  • [ISO-abbreviation] Case Rep Rheumatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3741952
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9. Atalar AC, Sungur M, Demirhan M, Ozger H: Neuropathic arthropathy of the shoulder associated with syringomyelia: a report of six cases. Acta Orthop Traumatol Turc; 2010;44(4):328-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Initial diagnosis, previous treatment, and radiological and clinical follow-up findings were reviewed.
  • The mean age at diagnosis was 44.2 years.
  • Biopsy was performed in 4 patients before definitive diagnosis, and synovial hypertrophy and necrotic bone was found.
  • As a conclusion, neuropathic arthropathy of the shoulder is rare, and correct diagnosis is possible by careful physical and neurological examination and pathologic evaluation when needed.

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  • (PMID = 21252611.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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10. Roddy E, Menon A, Hall A, Datta P, Packham J: Polyarticular sonographic assessment of gout: a hospital-based cross-sectional study. Joint Bone Spine; 2013 May;80(3):295-300
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  • OBJECTIVE: To assess the sonographic frequency of synovial effusion, synovial hypertrophy, synovitis, and double contour sign at joints commonly affected by gout and whether these features differ according to serum urate levels, disease duration, and use of urate-lowering therapy.
  • Sonographic examination of the metatarsophalangeal joints, ankles, knees, metacarpophalangeal joints, wrists and elbows for synovial effusion, synovial hypertrophy, synovitis and double contour sign was undertaken.
  • Synovial effusion, synovial hypertrophy, synovitis, and double contour sign were identified in 36 (90%), 38 (95%), 24 (62%) and 37 (93%) participants respectively.
  • Synovial effusion was seen most frequently at the knee (right 70%, left 68%) followed by the first metatarsophalangeal (right 48%, left 40%) and lesser metatarsophalangeal joints (right 45%, left 35%).
  • Synovial hypertrophy, synovitis, and double contour sign were seen most frequently at the first metatarsophalangeal joint (hypertrophy: right 65%, left 60%; synovitis: right 18%, left 18%; double contour: right 60%, left 68%).
  • CONCLUSION: Polyarticular sonography frequently identifies synovial effusion, synovial hypertrophy, synovitis and double contour sign in patients with gout, particularly at the metatarsophalangeal joints and knees.
  • [MeSH-major] Gout / ultrasonography. Knee Joint / ultrasonography. Metatarsophalangeal Joint / ultrasonography. Synovial Membrane / ultrasonography. Synovitis / ultrasonography

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  • [Copyright] Copyright © 2012 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.
  • (PMID = 23142256.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Journal Article; Observational Study; Research Support, Non-U.S. Gov't
  • [Publication-country] France
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11. Hemke R, van Veenendaal M, van den Berg JM, Dolman KM, van Rossum MA, Maas M, Kuijpers TW: One-year followup study on clinical findings and changes in magnetic resonance imaging-based disease activity scores in juvenile idiopathic arthritis. J Rheumatol; 2014 Jan;41(1):119-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Baseline and followup MRI features were scored by 2 readers using the Juvenile Arthritis MRI Scoring (JAMRIS) system, comprising validated scores for synovial hypertrophy, bone marrow changes, cartilage lesions, and bone erosions.
  • The clinically improved patients showed a significant reduction in synovial hypertrophy scores during followup (p < 0.001), with substantial effects (standardized response mean -0.70).
  • Significant differences were detected regarding a change in synovial hypertrophy scores comparing clinically improved and unimproved patients (p = 0.004), without statistically significant differences for changes in scores for bone marrow changes (p = 0.079), cartilage lesions (p = 0.165), and bone erosions (p = 0.078).
  • There is a strong association with clinical improvement according to the ACR-Ped50 criteria and changes in MRI-based synovial hypertrophy scores, supporting the role of MRI as a responsive outcome measure to evaluate disease activity with antiinflammatory treatment strategies.

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  • (PMID = 24293575.001).
  • [ISSN] 0315-162X
  • [Journal-full-title] The Journal of rheumatology
  • [ISO-abbreviation] J. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / Antirheumatic Agents
  • [Keywords] NOTNLM ; DISEASE ACTIVITY / JUVENILE IDIOPATHIC ARTHRITIS / KNEE / MAGNETIC RESONANCE IMAGING
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12. Chávez-López MA, Hernández-Díaz C, Moya C, Pineda C, Ventura-Ríos L, Möller I, Naredo E, Espinosa R, Peña A, Rosas-Cabral A, Filippucci E: Inter- and intra-observer agreement of high-resolution ultrasonography and power Doppler in assessment of joint inflammation and bone erosions in patients with rheumatoid arthritis. Rheumatol Int; 2013 Jan;33(1):173-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The OMERACT preliminary definitions of joint effusion, synovial hypertrophy, bone erosions and tenosynovitis were adopted.
  • Mean kappa value for joint effusion was good, 0.654 (85%); synovial hypertrophy, 0.550 (77.2%); power Doppler signal, 0.550 (82.5%); bone erosions, 0.549 (81%); and tenosynovitis, 0.500 (91.5%).
  • Mean and overall intra-observer agreement for semiquantitative score was good for joint effusion, 0.630 (77.2%) and bone erosions, 0.605 (56.25%); and moderate to synovial hypertrophy, 0.476 (65%) and power Doppler signal, 0.471 (80%).
  • Mean kappa value for joint effusion was 0.381 (95%), synovial hypertrophy, 0.447 (72%); power Doppler signal, 0.496 (81%); bone erosions, 0.294 (81%); and tenosynovitis, 0.030 (66%).
  • Mean and overall inter-observer agreement for semiquantitative score was poor for joint effusion, 0.325 (57%) and bone erosions, 0.360 (43%); and moderate to synovial hypertrophy, 0.431 (55%) and power Doppler signal, 0.496 (81%).


13. 'Synovial Hypertrophy Diagnosis': Top Publications. BioMedLib Review OC; ;SynovialHypertrophyDiagnosis:709904979. ISSN: 2331-5717. 2015/9/10; updates online.
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  • [Title] 'Synovial Hypertrophy Diagnosis': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy diagnosis'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 8 publications, and group two 560 publications.
  • Here are the top 4.
  • Scharstuhl A et al: Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
  • Chow JC et al: Hypertrophy of the synovium in the anteromedial aspect of the knee joint following trauma: an unusual cause of knee pain.
  • Hill CL et al: Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis.
  • Arct WA: [Unusual giant, chronic hypertrophy of the synovium of the knee joint].

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709904979.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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14. 'Hypertrophy Synovium': Top Publications. BioMedLib Review OC; ;HypertrophySynovium:709905007. ISSN: 2331-5717. 2015/4/10; updates online.
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  • [Title] 'Hypertrophy Synovium': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'hypertrophy synovium'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found into two groups.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 10 publications, and group two 564 publications.
  • Here are the top 6.
  • Scharstuhl A et al: Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis.
  • Bobacz K et al: Differentially regulated expression of growth differentiation factor 5 and bone morphogenetic protein 7 in articular cartilage and synovium in murine chronic arthritis: potential importance for cartilage breakdown and synovial hypertrophy.
  • Chow JC et al: Hypertrophy of the synovium in the anteromedial aspect of the knee joint following trauma: an unusual cause of knee pain.
  • Wyld PJ et al: Ultrasound in the assessment of synovial thickening in the hemophilic knee.
  • Pei M et al: Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy.
  • Hill CL et al: Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 709905007.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review OC
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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15. 'Synovial Hypertrophy Not Elsewhere Classified Disorder': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyNot:710412409. ISSN: 2331-5717. 2015/9/20; updates online.
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  • [Title] 'Synovial Hypertrophy Not Elsewhere Classified Disorder': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy not elsewhere classified disorder'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 63 publications.
  • Here are the top 10.
  • Jain K et al: Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy.
  • Hall M et al: Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms.
  • Li J et al: [Ultrasonographic characteristics of haemophilic arthropathy in the knee joints].
  • Kara A et al: Ochronosis diagnosed after knee arthroscopy.
  • Cooper IF et al: 'IndicatorsCMMA ReagentsCMMA or Diagnostic Aids' associated with 'Hemophiliac': Top Publications.
  • Little JP et al: Arthroscopic assessment of stifle synovitis in dogs with cranial cruciate ligament rupture.
  • Ramírez J et al: Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
  • Guillén Astete CA et al: Comparison of prevalence of synovitis by ultrasound assessment in subjects exposed or not to self-reported physical overexertion: the Monday's synovitis.
  • Cooper IF et al: 'Spatial Concepts' associated with 'Unilateral Hypertrophy': Top Publications.
  • Hemke R et al: One-year followup study on clinical findings and changes in magnetic resonance imaging-based disease activity scores in juvenile idiopathic arthritis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710412409.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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16. 'Synovial Hypertrophy Multiple Sites': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyMultiple:708374617. ISSN: 2331-5717. 2015/6/20; updates online.
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  • [Title] 'Synovial Hypertrophy Multiple Sites': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy multiple sites'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 2 publications.
  • Here is the first one.
  • Huebner JL et al: Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708374617.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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17. 'Synovial Hypertrophy Forearm': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyForearm:708374601. ISSN: 2331-5717. 2015/9/20; updates online.
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  • [Title] 'Synovial Hypertrophy Forearm': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy forearm'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 3 publications.
  • Here is the first one.
  • Steinert AF et al: Snapping elbow caused by hypertrophic synovial plica in the radiohumeral joint: a report of three cases and review of literature.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708374601.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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18. 'Synovial Hypertrophy Shoulder': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyShoulder:708374593. ISSN: 2331-5717. 2015/11/20; updates online.
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  • [Title] 'Synovial Hypertrophy Shoulder': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy shoulder'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 23 publications.
  • Here are the top 10.
  • Jain K et al: Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy.
  • Alasaarela E et al: Sonography and MRI in the evaluation of painful arthritic shoulder.
  • Alasaarela E et al: Ultrasound and operative evaluation of arthritic shoulder joints.
  • Coumbaras M et al: [Reactive synovitis: MRI features with arthroscopic correlation].
  • Yoneda M et al: Arthroscopic stapling for detached superior glenoid labrum.
  • Tezcan ME et al: Sterile osteitis and suppurative arthritis associated with pannus responding to colchicine.
  • Cooper IF et al: 'Diseases or Syndromes' associated with 'Unilateral Hypertrophy': Top Publications.
  • Riente L et al: Ultrasound imaging for the rheumatologist XLV. Ultrasound of the shoulder in psoriatic arthritis.
  • Iagnocco A et al: Ultrasound imaging for the rheumatologist XLIV. Ultrasound of the shoulder in healthy individuals.
  • Laktasić-Zerjavić N et al: [Standardised ultrasound scanning of the shoulder--normal and basic pathological findings].

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708374593.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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19. 'Synovial Hypertrophy Ankle And Foot': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyAnkle:708374614. ISSN: 2331-5717. 2015/11/20; updates online.
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  • [Title] 'Synovial Hypertrophy Ankle And Foot': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy ankle and foot'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 9 publications.
  • Here are the top 5.
  • Bowen CJ et al: Improvement in symptoms and signs in the forefoot of patients with rheumatoid arthritis treated with anti-TNF therapy.
  • Laurell L et al: Ultrasonography and color Doppler in juvenile idiopathic arthritis: diagnosis and follow-up of ultrasound-guided steroid injection in the ankle region. A descriptive interventional study.
  • Sharma H et al: Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry.
  • Cracchiolo A 3rd: Rheumatoid arthritis. Hindfoot disease.
  • Zhao QC et al: [Arthroscopic diagnosis and treatment of posttraumatic chronic ankle pain].

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708374614.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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20. 'Synovial Hypertrophy Nec In Snomedct': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyNec:710412393. ISSN: 2331-5717. 2015/2/20; updates online.
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  • [Title] 'Synovial Hypertrophy Nec In Snomedct': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy nec in snomedct'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 63 publications.
  • Here are the top 10.
  • Jain K et al: Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy.
  • Hall M et al: Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms.
  • Li J et al: [Ultrasonographic characteristics of haemophilic arthropathy in the knee joints].
  • Kara A et al: Ochronosis diagnosed after knee arthroscopy.
  • Guillén Astete CA et al: Comparison of prevalence of synovitis by ultrasound assessment in subjects exposed or not to self-reported physical overexertion: the Monday's synovitis.
  • Little JP et al: Arthroscopic assessment of stifle synovitis in dogs with cranial cruciate ligament rupture.
  • Ramírez J et al: Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
  • Cooper IF et al: 'Body PartsCMMA OrgansCMMA or Organ Components' associated with 'Unilateral Hypertrophy': Top Publications.
  • Hemke R et al: One-year followup study on clinical findings and changes in magnetic resonance imaging-based disease activity scores in juvenile idiopathic arthritis.
  • Hemke R et al: Contrast-enhanced MRI compared with the physical examination in the evaluation of disease activity in juvenile idiopathic arthritis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 710412393.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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21. 'Synovial Hypertrophy Hand': Top Publications. BioMedLib Review CN; ;SynovialHypertrophyHand:708374609. ISSN: 2331-5717. 2015/8/20; updates online.
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  • [Title] 'Synovial Hypertrophy Hand': Top Publications.
  • [Transliterated title]
  • Background: There are articles published each month which present 'synovial hypertrophy hand'.
  • Finding such articles is important for researchers, clinicians, and patients.
  • However these articles are spread across thousands of journals.
  • This makes searching and locating the relevant publications a challenge.
  • We have used BioMedLib's semantic search technology to address the issue, and gathered all the pertinent publications in this review article.
  • Methods: We categorized the publications we found.
  • We used the strength of textual-association to separate the groups.
  • In group one there are publications with the strongest evidence of association. We focused finding the most relevant publications pertinent to our goal, rather than combining them into a conclusion section. Such textual synthesis will be the focus of our next project.
  • Results: Group one includes 20 publications.
  • Here are the top 10.
  • Jain K et al: Short-term result of arthroscopic synovial excision for dorsal wrist pain in hyperextension associated with synovial hypertrophy.
  • Keen HI et al: Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.
  • Mancarella L et al: Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis.
  • Iagnocco A et al: Subclinical synovitis in primary Sjögren's syndrome: an ultrasonographic study.
  • Vlad V et al: Ultrasound in rheumatoid arthritis: volar versus dorsal synovitis evaluation and scoring.
  • Ingegnoli F et al: Power Doppler sonography and clinical monitoring for hyaluronic Acid treatment of rhizarthrosis: a pilot study.
  • Guillén Astete CA et al: Comparison of prevalence of synovitis by ultrasound assessment in subjects exposed or not to self-reported physical overexertion: the Monday's synovitis.
  • Cooper IF et al: 'Diseases or Syndromes' associated with 'Knee Arthritis Rheumatoid': Top Publications.
  • Cooper IF et al: 'Spatial Concepts' associated with 'Arrest Law': Top Publications.
  • Iagnocco A et al: Power Doppler ultrasound of the hand and wrist joints in systemic sclerosis.

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  • [Copyright] Copyright 2015 Siadaty and Cooper; licensee BioMedLib LLC.
  • (UID = 708374609.001).
  • [ISSN] 2331-5717
  • [Journal-full-title] BioMedLib Review CN
  • [Language] eng
  • [Publication-type] Review
  • [Publication-country] UNITED STATES
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22. Hemke R, Maas M, van Veenendaal M, Dolman KM, van Rossum MA, van den Berg JM, Kuijpers TW: Contrast-enhanced MRI compared with the physical examination in the evaluation of disease activity in juvenile idiopathic arthritis. Eur Radiol; 2014 Feb;24(2):327-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MRI features were evaluated using the JAMRIS system, comprising validated scores for synovial hypertrophy, bone marrow oedema, cartilage lesions and bone erosions.
  • Synovial hypertrophy scores differed significantly between groups (P = 0.016).
  • Nonetheless, synovial hypertrophy was also present in 14 JIA patients (35.9%) with clinically inactive disease.
  • [MeSH-major] Arthritis, Juvenile / diagnosis. Contrast Media / diagnostic use. Knee Joint / pathology. Magnetic Resonance Imaging / methods. Physical Examination / methods
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Prospective Studies. ROC Curve. Reproducibility of Results. Retrospective Studies. Severity of Illness Index


23. Ceponis A, Onishi M, Bluestein HG, Kalunian K, Townsend J, Kavanaugh A: Utility of the ultrasound examination of the hand and wrist joints in the management of established rheumatoid arthritis. Arthritis Care Res (Hoboken); 2014 Feb;66(2):236-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Agreement between sonographic synovial thickening and clinical findings was poor.
  • Total sonographic synovial hypertrophy or PD score correlated significantly with physician-recorded, but not patient-recorded, clinical outcomes.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Decision Support Techniques. Disability Evaluation. Feasibility Studies. Humans. Middle Aged. Pain Measurement. Patient Satisfaction. Patient Selection. Point-of-Care Systems. Predictive Value of Tests. Questionnaires. Synovial Membrane / drug effects. Synovial Membrane / ultrasonography. Synovitis / drug therapy. Synovitis / ultrasonography. Treatment Outcome

  • Genetic Alliance. consumer health - Arthritis.
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  • MedlinePlus Health Information. consumer health - Rheumatoid Arthritis.
  • ResearchGate. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • [Copyright] Copyright © 2014 by the American College of Rheumatology.
  • (PMID = 23983173.001).
  • [ISSN] 2151-4658
  • [Journal-full-title] Arthritis care & research
  • [ISO-abbreviation] Arthritis Care Res (Hoboken)
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antirheumatic Agents
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24. Machado FS, Natour J, Takahashi RD, de Buosi AL, Furtado RN: Sonographic assessment of healthy peripheral joints: evaluation according to demographic parameters. J Ultrasound Med; 2014 Dec;33(12):2087-98
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  • Quantitative synovial hypertrophy measurements and semiquantitative synovial hypertrophy, power Doppler, bone erosion (score 0-3), and articular cartilage (score 0-4) measurements were performed by a blinded radiologist using a 6-18-MHz linear array transducer.
  • The highest quantitative synovial hypertrophy values were found in the hip (6.4 mm) and talonavicular joint (2.6 mm).
  • The joint recesses with a greater frequency of hypothetical pathologic semiquantitative scores were second metatarsophalangeal (78.8%) and first metatarsophalangeal (69.3%) for synovial hypertrophy, radiocarpal (17.7%) and first metatarsophalangeal (15.8%) for power Doppler, and posterior glenohumeral (23.1%) and ulnocarpal (4.2%) for bone erosion.
  • The highest quantitative synovial hypertrophy values and the lowest semiquantitative synovial hypertrophy, power Doppler, bone erosion, and articular cartilage scores were observed in age group E (P < .046).

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  • [Copyright] © 2013 by the American Institute of Ultrasound in Medicine.
  • (PMID = 25425364.001).
  • [ISSN] 1550-9613
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Keywords] NOTNLM ; bone erosion / healthy volunteers / joint / musculoskeletal ultrasound / power Doppler sonography / sonography / synovial hypertrophy
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25. Nusman CM, Hemke R, Schonenberg D, Dolman KM, van Rossum MA, van den Berg JM, Kuijpers TW, Maas M: Distribution pattern of MRI abnormalities within the knee and wrist of juvenile idiopathic arthritis patients: signature of disease activity. AJR Am J Roentgenol; 2014 May;202(5):W439-46
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  • MATERIALS AND METHODS: MRI datasets of 153 clinically active JIA patients (110 with knee and 43 with wrist involvement) were evaluated independently by two readers for the presence of literature-based imaging features: "synovial hypertrophy," "bone marrow changes," "bone erosions," "tenosynovitis" (only in the wrist), and "cartilage lesions" (only in the knee) in accordance with validated definitions and scoring locations.
  • RESULTS: Synovial hypertrophy was most frequently observed--both in the knee and in the wrist (61.8-65.1% of cases).
  • For the knee, the most frequently involved locations were the cruciate ligaments (46/183 locations [25.1%] affected with synovial hypertrophy) and medial patella (18/62 locations [29.0%] with bone marrow changes).
  • For the wrist, most frequently involved were the radiocarpal joint (21/64 locations [32.8%] with synovial hypertrophy), lunate (7/46 locations [15.2%] with bone marrow changes), and capitate or triquetrum (6/28 locations [21.4%] with bone erosions).

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  • (PMID = 24758678.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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26. Gok M, Erdem H, Gogus F, Yilmaz S, Karadag O, Simsek I, Sagkan RI, Saglam M, Musabak U, Dinc A, Pay S: Relationship of ultrasonographic findings with synovial angiogenesis modulators in different forms of knee arthritides. Rheumatol Int; 2013 Apr;33(4):879-85
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  • [Title] Relationship of ultrasonographic findings with synovial angiogenesis modulators in different forms of knee arthritides.
  • The increased power Doppler (PD) signals determined by ultrasonography is an indirect marker of synovial vascularity in arthritis.
  • We aimed to investigate relationship between ultrasonographic findings and synovial angiogenesis modulators.
  • Cumulative effusion, synovial hypertrophy, and PD signal scores were calculated in arthritic joints.
  • In synovial fluid samples, angiogenesis inhibitors (angiostatin, thrombospondin-1, and endostatin) and stimulators [bFGF (basic fibroblast growth factor), angiopoietin-1] were studied.
  • Synovial hypertrophy scores were higher in RA and spondylarthritis than in OA and BD.
  • Synovial angiostatin and bFGF levels were significantly higher in patients with inflammatory arthritis than in OA.
  • Synovial hypertrophy scores were positively correlated with angiostatin and bFGF levels and negatively correlated with thrombospondin-1.
  • [MeSH-major] Arthritis, Rheumatoid / ultrasonography. Behcet Syndrome / ultrasonography. Knee Joint / ultrasonography. Osteoarthritis, Knee / ultrasonography. Spondylarthropathies / ultrasonography. Synovial Fluid / drug effects

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  • (PMID = 22811011.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Angiogenesis Inhibitors; 0 / Angiopoietin-1; 0 / Endostatins; 0 / Thrombospondin 1; 103107-01-3 / Fibroblast Growth Factor 2; 86090-08-6 / Angiostatins
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27. Riente L, Delle Sedie A, Sakellariou G, Filippucci E, Meenagh G, Iagnocco A, Cioffi E, Valesini G, Grassi W, Montecucco C, Bombardieri S: Ultrasound imaging for the rheumatologist XXXVIII. Sonographic assessment of the hip in psoriatic arthritis patients. Clin Exp Rheumatol; 2012 Mar-Apr;30(2):152-5
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  • Bilateral examination of the hip was performed to detect joint effusion, synovial hypertrophy, irregularity of femoral head and neck profile as seen in erosions and/or osteophytes.
  • Synovial hypertrophy was present in 12 out of 20 hips (60%) associated with effusion (9.3% of all hip joints) and only 1 of them showed PD signal.
  • Small effusion without synovial proliferation was imaged in 8 out of 20 hips (40%).
  • On the whole 14 out of 65 patients (21%) had joint effusion with or without synovial hypertrophy using US.
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Femur Head / ultrasonography. Femur Neck / ultrasonography. Humans. Hypertrophy. Italy. Male. Middle Aged. Northern Ireland. Predictive Value of Tests. Prognosis. Severity of Illness Index. Synovial Membrane / ultrasonography. Young Adult


28. Macchioni P, Magnani M, Mulè R, Galletti S, Catanoso M, Pignotti E, Boiardi L, Meliconi R, Salvarani C: Ultrasonographic predictors for the development of joint damage in rheumatoid arthritis patients: a single joint prospective study. Clin Exp Rheumatol; 2013 Jan-Feb;31(1):8-17
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  • METHODS: Two hundred and forty MCP joints of 24 patients with RA were prospectively evaluated both clinically and by ultrasound (US) at time 0, at six months and 12 months, in order to collect the following variables: presence of synovial hypertrophy and power-Doppler (PD) vascularisation both graded on a semiquantitative (0-3) scale, and the number and dimension of bone erosions.
  • RESULTS: Fifteen out of seventeen (88%) of the new eroded joints on x-rays examination had persistent PD vascularity and 14/17 (82%) had persistent synovial thickening (p=0.001 and p=0.02, vs. non-eroded joints, respectively).
  • In multiple conditional logistic regression analysis, the most important factor associated with the development of radiological joint damage was the presence of a synovial PD score ≥2 on two or more US evaluations (OR 8.51 [95%CI 1.84-39.48] for Rx new erosions and OR 8.30 [95%CI 1.97-38.9] for increased S/vdH local joint score).
  • Both baseline synovial score ≥2 and presence of Rx erosions were also significantly associated with the development of radiological joint damage.
  • CONCLUSIONS: At the single joint level, the presence of US determined synovial thickness and PD signal at baseline and the persistent PD signal over time have relevant prognostic value for the development of articular damage in the same MCP joints of RA patients.


29. Hemke R, Kuijpers TW, van den Berg JM, van Veenendaal M, Dolman KM, van Rossum MA, Maas M: The diagnostic accuracy of unenhanced MRI in the assessment of joint abnormalities in juvenile idiopathic arthritis. Eur Radiol; 2013 Jul;23(7):1998-2004
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  • Regarding the assessment of synovial hypertrophy, specificity of -Gd was high (0.97), but the sensitivity of unenhanced MRI was only 0.62.
  • Omitting intravenous Gd in the MRI assessment of joints in JIA is inadvisable, because it decreases the reliability of detecting synovial disease.
  • Synovial hypertrophy, a marker of JIA activity, is well shown by MRI.
  • • Omitting intravenous contrast medium decreases the reliability of synovial hypertrophy scores.
  • [MeSH-major] Arthritis, Juvenile / complications. Contrast Media / diagnostic use. Gadolinium / diagnostic use. Joint Diseases / diagnosis. Knee Joint / pathology. Magnetic Resonance Imaging / methods


30. Gutierrez M, Filippucci E, Salaffi F, Di Geso L, Grassi W: Differential diagnosis between rheumatoid arthritis and psoriatic arthritis: the value of ultrasound findings at metacarpophalangeal joints level. Ann Rheum Dis; 2011 Jun;70(6):1111-4
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  • [Title] Differential diagnosis between rheumatoid arthritis and psoriatic arthritis: the value of ultrasound findings at metacarpophalangeal joints level.
  • OBJECTIVE: To investigate the potential of ultrasound (US) in the differential diagnosis between rheumatoid arthritis (RA) and psoriatic arthritis (PsA) at metacarpophalangeal (MCP) joints level.
  • All US examinations were performed by two rheumatologists investigating: presence of joint cavity widening (JCW), synovial fluid and/or synovial hypertrophy, peritenon extensor tendon inflammation (PTI) and intra-articular or peri-tendinous power Doppler (PD) signal.
  • 15 of 83 (18%) MCP joints showed synovial fluid, whereas 68 of 83 (82%) MCP joints showed synovial hypertrophy.
  • 6 of 28 (21.4%) MCP joints presented synovial fluid, whereas 22 of 28 (78.5%) MCP joints showed synovial hypertrophy.
  • CONCLUSIONS: Preliminary results demonstrate that PTI pattern is a higher characteristic of PsA, which suggests a potential role of US in the differential diagnosis between RA and PsA at MCP joints level.
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Ultrasonography, Doppler / methods


31. Micu MC, Bogdan GD, Fodor D: Steroid injection for hip osteoarthritis: efficacy under ultrasound guidance. Rheumatology (Oxford); 2010 Aug;49(8):1490-4
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  • Synovial hypertrophy was reduced in 75% of the hips after 1 and 3 months vs baseline (P < 0.001).
  • In the group of controls, hip walking pain VAS, Lequesne index and synovial hypertrophy were not changed at 3 months vs baseline (P > 0.05).
  • CONCLUSION: US-guided steroid injections in hip OA is an efficacious and safe therapeutic approach to achieve pain control and reduction of synovial hypertrophy avoiding the use of X-ray-guided procedure.

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  • [CommentIn] Rheumatology (Oxford). 2011 Apr;50(4):812-3; author reply 813 [21292739.001]
  • [CommentIn] Rheumatology (Oxford). 2010 Aug;49(8):1427-8 [20360036.001]
  • (PMID = 20338889.001).
  • [ISSN] 1462-0332
  • [Journal-full-title] Rheumatology (Oxford, England)
  • [ISO-abbreviation] Rheumatology (Oxford)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antirheumatic Agents; 0 / Steroids
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32. Hemke R, van Rossum MA, van Veenendaal M, Terra MP, Deurloo EE, de Jonge MC, van den Berg JM, Dolman KM, Kuijpers TW, Maas M: Reliability and responsiveness of the Juvenile Arthritis MRI Scoring (JAMRIS) system for the knee. Eur Radiol; 2013 Apr;23(4):1075-83
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  • MRI features of synovial hypertrophy, bone marrow changes, cartilage lesions and bone erosions were independently scored by five readers using the JAMRIS system.
  • Concerning therapy response, the mean synovial hypertrophy scores decreased significantly (mean 1.1 point; P < 0.001, SRM = -0.65).


33. Tahasildar N, Sudesh P, Tripathy SK, Shashidhar BK: Bilateral pathological dislocation of the hip secondary to tuberculous arthritis following disseminated tuberculosis: a case report and review of the literature. J Pediatr Orthop B; 2012 Nov;21(6):567-73
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  • Several pathomechanisms including capsular laxity, synovial hypertrophy, and acetabular and proximal femur destruction have been described.


34. Hemke R, van Veenendaal M, Kuijpers TW, van Rossum MA, Maas M: Increasing feasibility and patient comfort of MRI in children with juvenile idiopathic arthritis. Pediatr Radiol; 2012 Apr;42(4):440-8
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  • MRI features were evaluated using a literature-based score, comprising synovial hypertrophy, cartilage lesions, bone erosions, bone marrow changes, infrapatellar fat pad heterogeneity, effusion, tendinopathy and popliteal lymphadenopathy.
  • Synovial hypertrophy was more frequent in group 1 (36.2%), but was also seen in 19.4% of the knees in group 2.
  • Signs differing among children with active and inactive disease include infrapatellar fat pad heterogeneity and synovial hypertrophy.
  • [MeSH-major] Arthritis, Juvenile / diagnosis. Knee Joint / pathology. Magnetic Resonance Imaging / methods

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  • [Cites] Acta Radiol. 2001 Jan;42(1):6-9 [11167323.001]
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  • (PMID = 22246410.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC3316772
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35. Iagnocco A, Vavala C, Vasile M, Stefanantoni K, Valesini G, Riccieri V: Power Doppler ultrasound of the hand and wrist joints in systemic sclerosis. Clin Exp Rheumatol; 2013 Mar-Apr;31(2 Suppl 76):89-95
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  • Each joint was evaluated for the presence of effusion, synovial hypertrophy, hyperaemia, bone erosions and cortical irregularities; in addition, local tendons for tenosynovitis and hyperaemia, and median nerve for entrapment neuropathy were examined.
  • RESULTS: Synovial hypertrophy was detected in 3% hand joints and in 46% wrists of SSc patients, with significant differences respect to controls (p=0.000004 and 0.000001, respectively).
  • Tenosynovitis was found in 6% out of the 1.196 synovial tendon sites examined of SSc patients with significant differences compared to healthy subjects (p=0.000001); PD resulted to be positive in 29% of them, with significantly differences compared to controls (p=0.0038).

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  • (PMID = 23190799.001).
  • [ISSN] 0392-856X
  • [Journal-full-title] Clinical and experimental rheumatology
  • [ISO-abbreviation] Clin. Exp. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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36. Bevers K, Zweers MC, van den Ende CH, Martens HA, Mahler E, Bijlsma JW, Wakefield RJ, van den Hoogen FH, den Broeder AA: Ultrasonographic analysis in knee osteoarthritis: evaluation of inter-observer reliability. Clin Exp Rheumatol; 2012 Sep-Oct;30(5):673-8
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  • The acquisition protocol comprised medial meniscus protrusion, synovial hypertrophy, effusion, infrapatellar bursitis and cartilage thickness.
  • RESULTS: Inter-observer agreement (κ-value) was moderate for protrusion of the medial meniscus (0.54), good for infrapatellar bursitis (0.66) and effusion (0.74), excellent for Bakers' cyst (0.85) and poor for the detection of synovial hypertrophy (-0.08).

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  • (PMID = 22765952.001).
  • [ISSN] 0392-856X
  • [Journal-full-title] Clinical and experimental rheumatology
  • [ISO-abbreviation] Clin. Exp. Rheumatol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Italy
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37. Yalçin N, Bektaşer B, Ciçekli O, Uğraş S, Doğan M: An unusual cause of recurrent joint effusions: nonhemophilic hemosiderotic synovitis of the knee. Acta Orthop Traumatol Turc; 2010;44(2):162-5
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  • Magnetic resonance imaging showed synovial hypertrophy and grade 2 degeneration in the medial meniscus.
  • During diagnostic and surgical arthroscopy, rust-colored synovial hypertrophy was noted in the suprapatellar pouch accompanied by patchy villi and nodules and cystic changes.
  • The gross appearance of the synovium mimicked that of pigmented villonodular synovitis.
  • Biopsy specimens were obtained from different parts of the synovium and a subtotal synovectomy was performed.
  • The histopathologic diagnosis was reported as hemosiderotic synovitis.
  • [MeSH-minor] Female. Hemosiderin / analysis. Humans. Magnetic Resonance Imaging. Menisci, Tibial / pathology. Synovial Membrane / pathology. Synovial Membrane / surgery. Young Adult

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  • (PMID = 20676020.001).
  • [ISSN] 1017-995X
  • [Journal-full-title] Acta orthopaedica et traumatologica turcica
  • [ISO-abbreviation] Acta Orthop Traumatol Turc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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38. Kawashiri SY, Kawakami A: [Musculoskeletal ultrasonography in rheumatoid arthritis]. Clin Calcium; 2012 Feb;22(2):187-92
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  • Ultrasonography is able to accurately evaluate synovial lesion, and it detect bone lesion in the patients with rheumatoid arthritis (RA) in early stage.
  • Power Doppler signals with synovial hypertrophy mean disease activity of RA.
  • Therefore, ultrasonography is very useful in not only the early diagnosis but also the evaluation of disease activity as well as evaluation of treatment choice in the patients with RA.
  • [MeSH-minor] Early Diagnosis. Humans. Musculoskeletal System / ultrasonography. Patient Education as Topic


39. Terslev L, D'Agostino MA, Brossard M, Aegerter P, Balint P, Backhaus M, Bruyn GA, Chary-Valckenare I, Filippucci E, Freeston J, Gandjbakhch F, Iagnocco A, Jousse-Joulin S, Mandl P, Möller I, Naredo E, Szkudlarek M, Wakefield RJ, Zayat A, Schmidt WA: Which knee and probe position determines the final diagnosis of knee inflammation by ultrasound? Results from a European multicenter study. Ultraschall Med; 2012 Dec;33(7):E173-8
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  • [Title] Which knee and probe position determines the final diagnosis of knee inflammation by ultrasound? Results from a European multicenter study.
  • PURPOSE: To investigate which knee and probe position best identifies knee inflammation and to determine a cut-off level for abnormal synovial effusion.
  • The presence of synovial effusion (SE), the effusion measured in millimeters and the presence of synovial hypertrophy (SH) was noted.
  • The detection of SH is more sensitive and specific than the detection of SE, independently of the knee and probe position, for the final diagnosis of abnormality.
  • The detection of both synovial hypertrophy and effusion in the knee in neutral position (0°) with quadriceps contraction and with the probe in the midline position, are the best independent predictors for knee abnormalities.
  • [MeSH-major] Arthritis / ultrasonography. Arthritis, Rheumatoid / ultrasonography. Osteoarthritis, Knee / ultrasonography. Patient Positioning. Synovial Fluid / ultrasonography
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Hypertrophy. Knee Joint / ultrasonography. Male. Middle Aged. Patella / ultrasonography. Range of Motion, Articular / physiology. Reference Values. Sensitivity and Specificity. Synovial Membrane / pathology. Synovial Membrane / ultrasonography. Young Adult

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  • [Copyright] © Georg Thieme Verlag KG Stuttgart · New York.
  • (PMID = 22194046.001).
  • [ISSN] 1438-8782
  • [Journal-full-title] Ultraschall in der Medizin (Stuttgart, Germany : 1980)
  • [ISO-abbreviation] Ultraschall Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Germany
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40. Iagnocco A, Filippucci E, Riente L, Meenagh G, Delle Sedie A, Sakellariu G, Ceccarelli F, Montecucco C, Bombardieri S, Grassi W, Valesini G: Ultrasound imaging for the rheumatologist XLI. Sonographic assessment of the hip in OA patients. Clin Exp Rheumatol; 2012 Sep-Oct;30(5):652-7
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  • US study included the assessment of both inflammatory and structural abnormalities at the level of hip joint (joint effusion, synovial hypertrophy, local pathologic vascularisation at PD, osteophytes) and periarticular soft tissues (iliopsoas bursitis, trochanteric bursitis, iliopsoas tendinopathy, gluteus medius tendinopathy and gluteus minimus tendinopathy).
  • US detected effusion in 50% of the joints, synovial hypertrophy in 41.3%, PD signal in 0.7%, osteophytes in 77.3%; at periarticular level, trochanteric bursitis was found in 24.7% of patients, gluteus tendinopathy in 22.7%, iliopsoas tendinopathy in 7.3% and finally iliopsoas bursitis in 1.3%.
  • [MeSH-minor] Aged. Arthralgia / diagnosis. Arthralgia / etiology. Asymptomatic Diseases. Chi-Square Distribution. Female. Humans. Italy. Male. Middle Aged. Pain Measurement. Predictive Value of Tests. Prognosis. Severity of Illness Index

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  • (PMID = 23075672.001).
  • [ISSN] 0392-856X
  • [Journal-full-title] Clinical and experimental rheumatology
  • [ISO-abbreviation] Clin. Exp. Rheumatol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] Italy
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41. Doria AS: State-of-the-art imaging techniques for the evaluation of haemophilic arthropathy: present and future. Haemophilia; 2010 Jul;16 Suppl 5:107-14
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  • SUMMARY: In spite of the fact that the diagnosis of haemophilia is essentially clinical and laboratory-based, imaging has become an important tool for the evaluation of complications, diagnostic confirmation and/or complementation and therapeutic follow-up in haemophilic arthropathy.
  • Radiography remains the workforce horse in the diagnosis and follow-up of haemophilic arthropathy.
  • One of these advantages is its ability of differentiating synovium hypertrophy and hemosiderin deposition, which is not possible with MRI given the presence of susceptibility artefacts from extracellular hemosiderin on gradient-echo MR images.
  • [MeSH-major] Cartilage / pathology. Diagnostic Imaging / history. Hemarthrosis / diagnosis. Hemophilia A / diagnosis. Joints / pathology. Magnetic Resonance Imaging / methods

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  • (PMID = 20590865.001).
  • [ISSN] 1365-2516
  • [Journal-full-title] Haemophilia : the official journal of the World Federation of Hemophilia
  • [ISO-abbreviation] Haemophilia
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radioisotopes
  • [Number-of-references] 62
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42. Di Minno MN, Iervolino S, Soscia E, Tosetto A, Coppola A, Schiavulli M, Marrone E, Ruosi C, Salvatore M, Di Minno G: Magnetic resonance imaging and ultrasound evaluation of "healthy" joints in young subjects with severe haemophilia A. Haemophilia; 2013 May;19(3):e167-73
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  • Taking into account only moderate/severe alterations, joint effusion was found in 55% of HA and in 5% of no-HA joints (P < 0.001); synovial hypertrophy was found in 20% of HA and in none of the no-HA joints; cartilage erosion was found in 30% of HA and in none of no-HA joints.
  • MRI and US data significantly correlated as to effusion (r = 0.819, P = 0.002), synovial hypertrophy (r = 0.633, P = 0.036) and cartilage erosion (r = 0.734, P = 0.010).

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  • [Copyright] © 2013 Blackwell Publishing Ltd.
  • (PMID = 23496145.001).
  • [ISSN] 1365-2516
  • [Journal-full-title] Haemophilia : the official journal of the World Federation of Hemophilia
  • [ISO-abbreviation] Haemophilia
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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43. Yao Y, Ding CZ, Fang Y: Combination of MTX and LEF attenuates inflammatory bone erosion by down-regulation of receptor activator of NF-kB ligand and interleukin-17 in type II collagen-induced arthritis rats. Rheumatol Int; 2013 Jul;33(7):1845-53
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  • Combination therapy would relive the synovium hypertrophy through depressing cell viability and osteoclasia through decreasing RANKL and increasing OPG expression.
  • [MeSH-minor] Animals. Cell Survival / drug effects. Cells, Cultured. Down-Regulation. Drug Therapy, Combination. Female. Fibroblasts / drug effects. Fibroblasts / immunology. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Osteoprotegerin / blood. Osteoprotegerin / metabolism. Rats. Rats, Sprague-Dawley. Synovial Membrane / drug effects. Synovial Membrane / immunology. Synovial Membrane / metabolism. Synovial Membrane / pathology. Time Factors

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  • HSDB. structure - METHOTREXATE.
  • HSDB. structure - LEFLUNOMIDE.
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  • (PMID = 23334376.001).
  • [ISSN] 1437-160X
  • [Journal-full-title] Rheumatology international
  • [ISO-abbreviation] Rheumatol. Int.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Collagen Type II; 0 / IL17 protein, rat; 0 / Interleukin-17; 0 / Isoxazoles; 0 / Osteoprotegerin; 0 / RANK Ligand; 0 / TNFRSF11B protein, human; 0 / TNFSF11 protein, human; 0 / Tnfrsf11b protein, rat; G162GK9U4W / leflunomide; YL5FZ2Y5U1 / Methotrexate
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44. Tămaş MM, Rednic N, Felea I, Rednic S: Ultrasound assessment for the rapid classification of early arthritis patients. J Investig Med; 2013 Dec;61(8):1184-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasound assessment was performed at the following anatomical sites: wrists, metacarpophalangeal joints 2 to 5, and metatarsophalangeal joints 2 to 5 for assessing the presence/absence of synovial hypertrophy, the presence/absence of power Doppler signal, and the presence/absence of bone erosions.The US features of inflammation and bone damage were analyzed in comparison with the DAS28, with the presence/absence of rheumatoid factor and anti-cyclic citrullinated peptide, with the fulfillment of the new 2010 ACR/EULAR classification criteria, and with the initiated disease-modifying antirheumatic drug.
  • Synovial hypertrophy, intra-articular power Doppler signal, and bone erosions detected in at least 1 anatomical site were seen in patients fulfilling (77.7%) and in patients not fulfilling (72.7%) the 2010 ACR/EULAR classification criteria for RA.
  • Synovial hypertrophy was found in at least 1 site in 83.3% and 58.8% of patients in whom methotrexate was prescribed and in whom methotrexate was not prescribed, respectively (P = 0.01).
  • [MeSH-minor] Adult. Early Diagnosis. Female. Humans. Male. Middle Aged. Prospective Studies. Time Factors

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  • (PMID = 24113730.001).
  • [ISSN] 1708-8267
  • [Journal-full-title] Journal of investigative medicine : the official publication of the American Federation for Clinical Research
  • [ISO-abbreviation] J. Investig. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
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45. Mancarella L, Magnani M, Addimanda O, Pignotti E, Galletti S, Meliconi R: Ultrasound-detected synovitis with power Doppler signal is associated with severe radiographic damage and reduced cartilage thickness in hand osteoarthritis. Osteoarthritis Cartilage; 2010 Oct;18(10):1263-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • US-detected features were: synovial hypertrophy, effusion, power Doppler signal (PDS), cartilage thickness.

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  • [Copyright] Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20656045.001).
  • [ISSN] 1522-9653
  • [Journal-full-title] Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
  • [ISO-abbreviation] Osteoarthr. Cartil.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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46. Hendry GJ, Gardner-Medwin J, Steultjens MP, Woodburn J, Sturrock RD, Turner DE: Frequent discordance between clinical and musculoskeletal ultrasound examinations of foot disease in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken); 2012 Mar;64(3):441-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The same sites were examined independently by a sonographer for effusion, synovial hypertrophy, power Doppler (PD) signal, tenosynovitis, or abnormal tendon thickening.
  • US-detected effusions, synovial hypertrophy, and PD signal were recorded in 88 (12.2%), 47 (6.5%), and 12 joints (1.7%), respectively.
  • [MeSH-major] Arthritis, Juvenile / diagnosis. Foot Diseases / diagnosis. Joints / ultrasonography

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  • [Copyright] Copyright © 2012 by the American College of Rheumatology.
  • (PMID = 21972178.001).
  • [ISSN] 2151-4658
  • [Journal-full-title] Arthritis care & research
  • [ISO-abbreviation] Arthritis Care Res (Hoboken)
  • [Language] eng
  • [Grant] United Kingdom / Arthritis Research UK / / 06/S0703129
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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47. Li J, Ding X, Lyu B, Xue F, Sun Q, Guo X, Li D, Zhang W, Zhang W, Xu Y, Yang R: [Ultrasonographic characteristics of haemophilic arthropathy in the knee joints]. Zhonghua Xue Ye Xue Za Zhi; 2014 May;35(5):434-7
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  • The prevalences of hydrops articuli, fibrotic septa, synovial hypertrophy, synovial hypertrophy with angiogenesis, haemosiderin deposition were 39.2% (53/135), 3.0% (4/135), 77.0% (104/135), 49.6% (67/135), 37.8% (51/135), respectively; and the prevalences of cartilage damage, bone erosion, bone remodeling, osteophytes were 63.7% (86/135), 48.1% (65/135), 3.0% (4/135), 13.3% (18/135) respectively.
  • CONCLUSION: The main characteristics of ultrasonography of haemophilic arthropathy in knee joints were identified as followings: synovial hypertrophy, cartilage damage, bone erosion, hydrops articuli, and haemosiderin deposition.

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  • (PMID = 24857215.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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48. Zhang W, Dai SM: Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis. Int Immunopharmacol; 2012 Sep;14(1):27-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Preclinical studies show that TGP/paeoniflorin is able to diminish pain, joint swelling, synovial hypertrophy, and the severity of bone erosion and cartilage degradation in experimental arthritis.
  • [MeSH-minor] Animals. Bone and Bones / drug effects. Bone and Bones / immunology. Clinical Trials as Topic. Drugs, Chinese Herbal / therapeutic use. Humans. Inflammation Mediators / metabolism. Lymphocyte Activation / drug effects. Medicine, Chinese Traditional. Monoterpenes. Oxidative Stress / drug effects. Synovial Membrane / drug effects. Synovial Membrane / immunology

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  • [Copyright] Copyright © 2012 Elsevier B.V. All rights reserved.
  • (PMID = 22705050.001).
  • [ISSN] 1878-1705
  • [Journal-full-title] International immunopharmacology
  • [ISO-abbreviation] Int. Immunopharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Benzoates; 0 / Bridged Compounds; 0 / Drugs, Chinese Herbal; 0 / Glucosides; 0 / Inflammation Mediators; 0 / Monoterpenes; 23180-57-6 / peoniflorin
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49. Muça-Perja M, Riva S, Grochowska B, Mangiafico L, Mago D, Gringeri A: Ultrasonography of haemophilic arthropathy. Haemophilia; 2012 May;18(3):364-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • To assess the joint status and the role of ultrasonography in routine diagnosis and monitoring of joint disease in cohort haemophilic patients.
  • Findings of patients with haemophilia, who routinely underwent ultrasonography were retrospectively evaluated to assess their joint status and the role of ultrasonography in routine diagnosis and monitoring of joint disease.
  • Synovial hypertrophy and cartilage abnormalities were the most frequent observations (88% and 76% in affected knees, respectively).

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  • [Copyright] © 2011 Blackwell Publishing Ltd.
  • (PMID = 21999202.001).
  • [ISSN] 1365-2516
  • [Journal-full-title] Haemophilia : the official journal of the World Federation of Hemophilia
  • [ISO-abbreviation] Haemophilia
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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50. Chakr RM, Mendonça JA, Brenol CV, Xavier RM, Brenol JC: Assessing rheumatoid arthritis disease activity with ultrasound. Clin Rheumatol; 2013 Sep;32(9):1249-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gray scale ultrasound identifies synovial hypertrophy and effusion with its good soft tissue contrast.
  • [MeSH-major] Arthritis, Rheumatoid / diagnosis. Arthritis, Rheumatoid / ultrasonography. Joints / ultrasonography. Synovitis / ultrasonography


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